Recent Advancements in Spectrophotometric pKa Determinations: A Review

Indian Journal of Pharmaceutical Education and Research

  • Job Herman Berkhout1Faculty of Science, Radboud University, Nijmegen, NETHERLANDS.
  • Aswatha Ram HN2Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, INDIA.

Volume 53 Issue 4s Pages s475-s480

DOI: 10.5530/ijper.53.4s.141

Abstract

The pKa value is a key feature in Absorption, Distribution, Metabolism and Excretion (ADME) of drugs, thus knowing this value is critical in drug development. In this review, pKa values determined in the past decade, using UV-Vis spectrometry, are discussed. To determine the pKa, four methods were applied; Henderson-Hasselbach, Albert-Serjeant, Bates-Schwarzenbach and Spectrometric titrations. This review will show the value of this aged but well-established technique in the past decade, due to its simplicity, accuracy, cost efficiency and reproducibility.

Keywords

  • Albert-Serjeant
  • Bates-Schwarzenbach
  • Henderson-Hasselbach
  • pKa
  • Spectroscopy
  • Titrations
IJOPP

Loading…