Liquisolid Compact Tablet of Candesartan Cilexetil with Enhanced Solubility using Neusilin US2, Aerosil 200 and Transcutol HP

Indian Journal of Pharmaceutical Education and Research

  • Pallavi Argade1Department of Pharmaceutics, JSPM Rajarshi Shahu College of Pharmacy and Research, Tathawade, Pune, Maharashtra, INDIA.
  • Vinita Chandrakant Patole1Department of Pharmaceutics, JSPM Rajarshi Shahu College of Pharmacy and Research, Tathawade, Pune, Maharashtra, INDIA.
  • Ashlesha Pravin Pandit1Department of Pharmaceutics, JSPM Rajarshi Shahu College of Pharmacy and Research, Tathawade, Pune, Maharashtra, INDIA.

Volume 53 Issue 3 Pages 457-467

DOI: 10.5530/ijper.53.3.78

Abstract

Objective: An attempt was made to enhance solubility, dissolution and intestinal permeability of drug candesartan cilexetil by liquisolid technology. Methods: Liquisolid tablet was formulated using non-volatile solvent Transcutol HP, carrier material Neusilin US2 and coating material Aerosil 200. Appropriate quantities of excipients were calculated with the help of mathematical model to get liquisolid powder. A 32 full-factorial design was used further to optimize liquisolid powder. Results: DSC, XRD and SEM studies revealed absence of crystalline nature of drug in liquisolid powder. Liquisolid powder was further compressed into tablet and subjected to various evaluation tests such as in-vitro drug release and ex-vivo intestinal permeation study. Conclusion: Liquisolid technology was found to be promising due to enhance solubility, dissolution and permeation of candesartan cilexetil by 19.75, 3.09 and 2.4-fold, respectively.

Keywords

  • Candesartan cilexetil
  • Transcutol HP
  • Neusilin
  • Aerosil 200
  • Liquisolid
  • technology
  • ex-vivo study
IJOPP

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