Effect of Sustained Release Polymers on Drug Release Profile of Aceclofenac TabletsPhysicochemical Properties, Analysis of Kinetics and Fit Factor

Indian Journal of Pharmaceutical Education and Research

  • Uzair Nagra1Faculty of Pharmacy, University of Lahore, Lahore, PAKISTAN.
  • Sherjeel Adnan1Faculty of Pharmacy, University of Lahore, Lahore, PAKISTAN.
  • Sana Shafqat1Faculty of Pharmacy, University of Lahore, Lahore, PAKISTAN.
  • Maryam Shabbir1Faculty of Pharmacy, University of Lahore, Lahore, PAKISTAN.
  • Sajid Ali1Faculty of Pharmacy, University of Lahore, Lahore, PAKISTAN., 2Department of Pharmaceutical Technology and Biopharmaceutics, Philipps University, Marburg, GERMANY.
  • Anum Zafar1Faculty of Pharmacy, University of Lahore, Lahore, PAKISTAN.
  • Syed Saeed ul Hassan1Faculty of Pharmacy, University of Lahore, Lahore, PAKISTAN.
  • Javed Iqbal1Faculty of Pharmacy, University of Lahore, Lahore, PAKISTAN.

Volume 53 Issue 2s Pages s58-s65

DOI: 10.5530/ijper.53.2s.49

Abstract

Aim: The sustained release tablets of Aceclofenac were prepared and evaluated for the sustained release drug profile with an aim to reduce dosing frequency and provide patient compliance. Materials and Method: The tablets were prepared by using different percentages of Kollidon SR, Carbopol 934P and Eudragit L100 and their combination thereof by wet granulation method. The tablets were analyzed for post compression studies including thickness, diameter, mechanical strength and uniformity of content. The in vitro dissolution studies were carried out in pH 1.2 for first 2 h and in pH 6.8 buffer for total of 12 h. Results: The tablets exhibited acceptable physicochemical characteristics as per USP limits. The formulation containing Eudragit L100 failed to give the desired sustained release effect where as a slow drug release was observed in formulations containing Carbopol 934P. Therefore, a combination of pH dependant polymer (Eudragit L100) and pH independent polymer (Carbopol 934P) combination was used. The formulations were also prepared by Carbopol 934P with plastic polymer (Kollidon SR). The desired sustained release effect was given by latter combination at 2:1 concentration. Conclusion: This formulation, U13, followed zero order kinetics with nonFickian drug release mechanism. When compared to the marketed brand by fit factor, U13 gave the ƒ2 value greater than 50 indicating closer proximity to the approved brand.

Keywords

  • Aceclofenac
  • Fit factor
  • Kinetics
  • Carobopol
  • Kollidon
  • Eudragit L100
IJOPP

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