Comparative Study of Various Non-Nucleoside Reverse Transcriptase Inhibitors on Different Reverse Transcriptase Enzyme
Indian Journal of Pharmaceutical Education and Research
Shital Manoj Patil1Department of Pharmaceutical chemistry, All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy, Pune, INDIA.
Kalyani Dhirendra Asgaonkar1Department of Pharmaceutical chemistry, All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy, Pune, INDIA.
Trupti Sameer Chitre1Department of Pharmaceutical chemistry, All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy, Pune, INDIA.
Aditi Kinikar1Department of Pharmaceutical chemistry, All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy, Pune, INDIA.
Chaitali Kharat1Department of Pharmaceutical chemistry, All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy, Pune, INDIA.
Vaibhavi Bhoirekar1Department of Pharmaceutical chemistry, All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy, Pune, INDIA.
Madhura Athavale1Department of Pharmaceutical chemistry, All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy, Pune, INDIA.
Mitali Katkar1Department of Pharmaceutical chemistry, All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy, Pune, INDIA.
<strong>Context:</strong> Acquired immunodeficiency Syndrome (AIDS) is caused by Human immunodeficiency virus type 1 (HIV-1). 4-Thiazolidone nulecus is the target pharmacophore which have diverse biological activities including anti HIV activity. Aim: To study binding behavior of thiazolidinone derivatives on four different crystal structures of HIV- 1RT. Material and Method: Binding pattern of some thiazolidinone derivatives was gauged by molecular docking studies on four different receptors bearing PDB code 1ZD1, 1RT2, 1KLM, 1FKP of HIV–RT enzyme using V. Life MDS software. Result and Discussion: The studies revealed hydrogen bonds, hydrophobic interaction and pi-pi interactions playing significant role in binding of the molecules to the enzyme. Conclusion: Interactions, binding energy and dock score of molecule 6 was comparable with the standard drugs.
