In vitro Antimicrobial Investigations of Newly Synthesized Transitional Bivalent Metal Complexes Derived from 8-Hydroxyquinoline

Indian Journal of Pharmaceutical Education and Research

  • Sahoo Jyotirmaya1Department of Pharmaceutics, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, Orissa, INDIA.
  • Sarangi Priyam Kshiroda Nandini2Departmentof Pharmaceutical Chemistry, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, Orissa, INDIA.
  • Paidesetty Sudhir Kumar3Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar, Orissa, INDIA.

Volume 51 Issue 3 Pages 480-489

DOI: 10.5530/ijper.51.3.76

Abstract

Introduction: Novel Cu(II), Co(II) and Ni(II) complexes of 8-hydroxyquinolineazo analogues are synthesized from 5-((3-nitrophenyl)diazenyl) quinolin-8-ol (4a) and 5-((4-bromo-3- methylphenyl) diazenyl) quinolin-8-ol (4b). Methods: The structural environment and elemental composition of the synthesized metal complexes are confirmed by FT/IR, 1H NMR and CHNS/O elemental analyzer. The λmax and molecular mass are determined with the help of UV-visible and LC-MS spectrometer. Results: The magnetic susceptibility study suggested that the synthesized complexes are proposed with tetrahedral geometry. Among the six complexes, the bis bis 8, 8′ [5-((3-nitrophenyl) diazenyl) quinolinium] copper (4aLig2Cu) and bis 8, 8′ [5-((4-bromo-3-methylphenyl) diazenyl) quinolinium] copper (4bLig2Cu) showed significant antimicrobial activity. Conclusion: It was found that the metal complexes showed enhanced antimicrobial activity in comparison to their corresponding ligands.

Keywords

  • Spectroscopic
  • Magnetic susceptibility
  • Antimicrobial
  • 8-Hydroxy quiniline
  • Antibiogram
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