Effects of Rutin on Testicular Antioxidant Enzymes and Lipid Peroxidation in Rats

Indian Journal of Pharmaceutical Education and Research

  • Rahmat Ali Khan1Department of Biotechnology, Faculty of Biological Sciences, University of Science and Technology Bannu, Khyber Pakutunkhwa, PAKISTAN.
  • Muhammad Rashid Khan2Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University Islamabad, PAKISTAN.
  • Mushtaq Ahmed1Department of Biotechnology, Faculty of Biological Sciences, University of Science and Technology Bannu, Khyber Pakutunkhwa, PAKISTAN.
  • Mir Sadiq Shah1Department of Biotechnology, Faculty of Biological Sciences, University of Science and Technology Bannu, Khyber Pakutunkhwa, PAKISTAN.
  • Shoiab Ur Rehman1Department of Biotechnology, Faculty of Biological Sciences, University of Science and Technology Bannu, Khyber Pakutunkhwa, PAKISTAN.
  • Jahangir Khan3Department of Pharmacy, University of Malakand, Chakdara Dir, Khyber Pakutunkhwa, PAKISTAN.
  • Masroor Husain1Department of Biotechnology, Faculty of Biological Sciences, University of Science and Technology Bannu, Khyber Pakutunkhwa, PAKISTAN.
  • Farman Ali Khan4Department of Biochemistery, Abdul Wali Khan University Mardan, 23200, Khyber Pakutunkhwa, PAKISTAN.
  • Muhammad Mohibullah Khan5Department of Plant Breeding and Genetics, .
  • Muhammad Shahzad Shifa6Department of Physics Government College University Faisalabad, .

Volume 51 Issue 3 Pages 412-417

DOI: 10.5530/ijper.51.3.69

Abstract

Background: Rutin, a polyphenolic flavonoid, possesses antioxidant and hypoglycemic effects. Objective: The present study was conducted to check the effect of rutin on serum reproductive hormonal level and sperm concentration in male rat. Methods: 30 rats were equally divided into 3 groups (10 rats per group). Group I was control (untreated), group II was given rutin 50 mg/kg bw while group III was given 100 mg/ kg bw intragastric twice a week for four weeks respectively. The effect of rutin on antioxidant enzymes (POD, SOD, GSHpx, GST, GSR), glutathione contents and TBARS contents were checked. Results: The results revealed that rutin caused significant gain in body weight, antioxidant enzymes (POD, SOD, GSHpx, GST, GSR), glutathione contents, with significant (P< 0.01) decrease in thiobarbituric acid reactive substance (TBARS) concentrations. Conclusion: It may be concluded that rutin may be promising as a natural therapeutic agent in male reproductive dysfunction.

Keywords

  • Rutin
  • TBARS contents
  • Antioxidant enzymes
  • Flavonoids
  • Catalase
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