Synthesis, Evaluation and Molecular Docking Study of Some New 2-[(2,5-Disubstitutedanilino) Phenyl] Acetic Acid Derivatives

Indian Journal of Pharmaceutical Education and Research

  • Shashidhar Kerur1Deparment of Pharmaceutical Chemistry, Karnataka Lingayath Education University College of Pharmacy, Hubli-580031, INDIA.
  • Kallanagouda Alagawadi2Deparment of Pharmaceutical Chemistry, Karnataka Lingayath Education University College of Pharmacy, Belgaum-580010, INDIA.
  • Hailiang Zhu3State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing-210093, CHINA.
  • Fakkirappa Manvi2Deparment of Pharmaceutical Chemistry, Karnataka Lingayath Education University College of Pharmacy, Belgaum-580010, INDIA.

Volume 50 Issue 3 Pages 465-471

DOI: 10.5530/ijper.50.3.21

Abstract

In the present study synthesis and antimicrobial activity of some new 2-[(2,5-disubstitutedanilino)phenyl]acetic acid derivatives 5a-f are described. The structures of the newly synthesized compounds were confirmed by FTIR, 1H NMR, 13C NMR, mass and elemental analysis. All compounds were screened for antitubercular and antimicrobial activity. Molecular modeling studies were performed to dock compounds into the ecKAS III binding site, which suggested probable inhibition mechanism. The results revealed that most of the compounds showed high to moderate biological activity against tested microorganisms.

Keywords

  • 1
  • 3
  • 4-Thiadiazole
  • Phenacyl bromide
  • Molecular Docking
  • Antitubercular
  • activity
  • Antimicrobial activity
  • Mycobacterium tuberculosis
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