A New Kinetic Approach. Stability of Cefquinome Sulfate under Variable pH and Temperature

Indian Journal of Pharmaceutical Education and Research

  • Mengjiao Liu1Department of Pharmacy, College of Veterinary Medicine, Sichuan Agriculture University, Ya, an, Sichuan-625014, China.
  • Qiang Fu1Department of Pharmacy, College of Veterinary Medicine, Sichuan Agriculture University, Ya, an, Sichuan-625014, China.
  • Hualin Fu1Department of Pharmacy, College of Veterinary Medicine, Sichuan Agriculture University, Ya, an, Sichuan-625014, China.
  • Gang Shu1Department of Pharmacy, College of Veterinary Medicine, Sichuan Agriculture University, Ya, an, Sichuan-625014, China.
  • Wei Zhang1Department of Pharmacy, College of Veterinary Medicine, Sichuan Agriculture University, Ya, an, Sichuan-625014, China.
  • Fengying Deng1Department of Pharmacy, College of Veterinary Medicine, Sichuan Agriculture University, Ya, an, Sichuan-625014, China.
  • Jun Hu1Department of Pharmacy, College of Veterinary Medicine, Sichuan Agriculture University, Ya, an, Sichuan-625014, China.

Volume 48 Issue 4s Pages s27-s33

DOI: 10.5530/ijper.48.4s.4

Abstract

Object: This study was evaluation of Cefquinome Sulfate (CS) long-term stability under different conditions of pH and temperature, so as to suggest the best conditions to perform its clinical application. Method: The CS stability was investigated at different values of pH (2.0-9.0) and temperature (4-370C). Kinetic parameters of CS degradation in alkaline environment were calculated adopting a new model that took into consideration the equilibrium between the active and a reversibly inactivated form of CS after long-time degradation. Result: All temperatures show increased CS instability,and this effect decreased in following sequence: 370C>250C>150C>40C, which describe typical Arrhenius behaviors with good correlation for Kd(R2= 0.941). Conclusion: The alkali-catalyzed degradation of CS was faster and stronger than the acidic one. The best conditions were met at a pH6.8 and 40C .

Keywords

  • CS
  • Kinetic parameters
  • stability
  • Arrhenius
IJOPP

Loading…