Structural Modification of Proteins and Peptides

Indian Journal of Pharmaceutical Education and Research

  • Anubha Mahajan1Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, Pushp Vihar, Sector-3, M. B. Road, New Delhi, India – 110017.
  • Ashwani Singh Rawat1Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, Pushp Vihar, Sector-3, M. B. Road, New Delhi, India – 110017.
  • Nidhi Bhatt1Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, Pushp Vihar, Sector-3, M. B. Road, New Delhi, India – 110017.
  • Meenakshi K. Chauhan1Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, Pushp Vihar, Sector-3, M. B. Road, New Delhi, India – 110017.

Volume 48 Issue 3 Pages 34-47

DOI: 10.5530/ijper.48.3.6

Abstract

Proteins and peptides are ubiquitous in every cell and thus are vital for various biological functions. In recent years, there is an extensive growth in the development of various biologicals and large molecules like proteins and peptides. Now, they are replacing the market of existing organic based pharmaceuticals. This review article intends to summarize various structural modifications that are carried out in order to alter basic properties of peptides and proteins so that their solubility, absorption, permeability and various other problems associated with their delivery can be resolved. Thus they can offer significant therapeutic potential.

Keywords

  • Proteins
  • peptides
  • Prodrugs
  • PEGylation
  • Polysialation
  • Lipidization
  • Hydrophobic ion pairing
  • Cylcodextrins
  • Nobex technology
  • Emisphere Technology
IJOPP

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