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Tue, 02/10/2015 - 09:46  |  Anonymous
Published on:10th Feb 2015
Indian Journal of Pharmaceutical Education and Research, 2010; 44(4):345-349
Pharmaceutical Education | doi:Nill

Effect of Different Acids on the Formation of E and Z Isomers of Doxepin


Authors and affiliation (s):

G.K. Rao1*, A.R. Ramesha2, Amit Kumar Jain1 and B.V. AdaviRao1

1Department of Pharmaceutical Chemistry, Al-Ameen College of Pharmacy-Bangalore

2R.L.Fine Chemicals, Yelahanka, Bangalore

Abstract:

Doxepin is an important antidepressant drug useful in the treatment of mild to moderate endogenous depression. The synthesis of doxepin involves acid catalysis leading to the formation of E- and Z- isomers. So herein, we report the use and effect of various acid catalysts on the formation E- and Z- isomers. Characterization of both the isomers was achieved by using HPLC and NMR. Both NMR and HPLC analysis showed that E-isomer as the major component.

Key Words: Doxepin, E and Z isomer, NMR and HPLC

 




 

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