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Published on:January 2024
Indian Journal of Pharmaceutical Education and Research, 2024; 58(1s):s58-s66
Review Article | doi:10.5530/ijper.58.1s.5

Molecular Insights into Salicylate Synthase: From Medicinal Chemistry Perspective


Authors and affiliation (s):

Nitin Bire1 , Vinayak Walhekar1 , Omkar Makane1 , Pranali Yelchatwar1 , Amol Muthal2 , Subhash Bodhankar2 , Chandrakant Bagul1 , Dileep Kumar1,5,6, Baswaraju Macha3 , Raghavendra Kulkarni4 , Vaibhav Shinde7 , Ravindra Kulkarni1,*

1Department of Pharmaceutical Chemistry, BVDU’S Poona College of Pharmacy, Erandwane Pune, Maharashtra, INDIA.

2Department of Pharmacology, BVDU’s Poona College of Pharmacy, Paudh Road, Erandawane, Pune, Maharashtra, INDIA.

3Department of Pharmaceutical Chemistry, UCPSc, Kakatiya University, Warangal, Telangana, INDIA.

4Department of Pharmaceutics, Sri Sanganabasava Mahaswamiji College of Pharmacy and Research Center, Vijayapura, Karnataka, INDIA.

5Department of Entomology, University of California, Davis, One Shields Ave, Davis, CA, USA.

6UC Davis Comprehensive Cancer Centre, University of California, Davis, One Shields Ave, Davis, CA, USA.

7Department of Pharmacognosy, BVDU’s Poona College of Pharmacy, Paud Road, Erandawane, Pune, Maharashtra, INDIA.

Abstract:

Tuberculosis is a pathogenic infection that has created trepidation around the globe due to its repercussion on the health of patients. The iron transport mechanism in mycobacterium plays a pivotal role in bacterial survival; whilst this can be considered an emerging drug target. Salicylate synthase is a member of the MST family and this enzyme is distrait in mammals. It is the first enzyme for the synthesis of mycobactin (siderophores) which is a determinant for iron transport. The present all-embracing review provides overall coverage of the biological and structural outlook of the enzyme salicylate synthase and its inhibitors reported in recent years. Furthermore, this review sheds limelight on the development of novel and more potent salicylate synthase inhibitors.

Keywords: Mycobacterium tuberculosis, Anti-tubercular drug targets, Siderophores, Mycobactin, Salicylate synthase (MbtI).

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
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Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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