https://www.ijper.org/comparative-analysis-of-dmf-filing-procedure-and-regulatory-requirements-in-indi 2026-04-30T11:57:22.155716+00:00 Comparative Analysis of DMF Filing Procedure and Regulatory Requirements in India, Brazil, and Canada 2026-12-06 10.5530/ijper.20266474 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-11.pdf DMF is a confidential document that provides detailed information about the API dosage form in Pharmaceuticals. DMF is also about the drug product. This investigation comprehensively analyses regulatory requirements and Drug Master File filing procedures in India, Brazil, and Canada in three diverse pharmaceutical markets. The analysis explores distinct regulatory agencies governing Pharmaceuticals in each country, including the Central Drug Standard Control Organisation (CDSCO) in India, the Ag Active Pharmaceutical Ingredient (API), CPID (Certificate Product Information Document), DIFA (Active Pharmaceutical Ingredient dossier or the DMF), MF (Master File), US Food and Drug Administration (USFDA) https://www.ijper.org/development-and-statistical-optimization-of-aquasomes-containing-ketoprofen-2-fa 2026-04-25T07:44:24.636395+00:00 Development and Statistical Optimization of Aquasomes Containing Ketoprofen: 2-Factor 2-Level Factorial Design Approach 2026-12-06 10.5530/ijper.20260916 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-145.pdf Purpose: The purpose of the research work was to develop Aquasomes containing Ketoprofen (AQ-KP) for enhanced stability of the drug with improved therapeutic effect. Materials and Methods: The aquasomes are formulated by co-precipitation method using calcium phosphate as a core layer, lactose and cellulose as core coated layer. Ketoprofen was adsorbed on lactose and cellulose layers. The three-layer formulations are developed with varying concentration of lactose and cellulose for preliminary tr Aquasomes, Ketoprofen, Optimization. https://www.ijper.org/pharmacokinetics-studies-of-lurasidone-hydrochloride-in-nano-structured-lipid-ca 2026-04-25T07:58:44.783011+00:00 Pharmacokinetics Studies of Lurasidone Hydrochloride in Nano Structured Lipid Carrier Formulation for Nasal to Brain Delivery 2026-12-06 10.5530/ijper.20260543 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-159.pdf Aim: Lurasidone Hydrochloride (LH) is a benzothiazole derivative used as an antipsychotic drug for the treatment of schizophrenia. Oral administration of Lurasidone hydrochloride, however, results in low bioavailability and inadequate concentration of Lurasidone in the brain tissue. Therefore, to improve the bioavailability and to achieve desired drug concentration at the site of action, intra nasal administration could be a feasible, non-invasive route for targeting the brain. The current study Nano Lipid Complex, Lurasidone Hydrochloride, Pharmacokinetics, Bio-distribution, RP-HPLC. https://www.ijper.org/leveraging-factorial-design-for-enhancing-formulation-of-ketorolac-tromethamine 2026-04-25T07:44:15.749504+00:00 Leveraging Factorial Design for Enhancing Formulation of Ketorolac Tromethamine Fast-Disintegrating Tablets 2026-12-06 10.5530/ijper.20260504 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-136.jpg Aim: Fast disintegrating tablets of Ketorolac tromethamine were prepared by formulating it with various super disintegrants with view to reduce disintegration time of tablets and to increase dissolution properties. Materials and Methods: The study employed One Factor at a Time (OFAT) tests to identify crucial variables and optimal response ranges. The primary factors affecting the disintegration time and drug release were found to be Croscarmellose sodium, Crospovidone, and Magnesium stearate co Ketorolac tromethamine, Croscarmellose sodium, Crospovidone and magnesium stearate, One Factor at a Time approach (OFAT). https://www.ijper.org/formulation-characterization-and-optimization-of-transdermal-patches-of-venlafax 2026-04-25T07:43:29.652939+00:00 Formulation, Characterization and Optimization of Transdermal Patches of Venlafaxine Hydrochloride Using 32 Full Factorial Approach 2026-12-06 10.5530/ijper.20265993 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-93.pdf Introduction: The primary objective of the present investigation was to develop transdermal patches that would extend the half-life of Venlafaxine Hydrochloride and boost its bioavailability. Transdermal patches were made with Ethyl Cellulose (EC) as the lipophilic component and Hydroxypropyl Methylcellulose (HPMC K15M) as the hydrophilic matrix. Objectives: The objectives of the present study it to develop effective transdermal patches for Venlafaxine Hydrochloride delivery, optimize their form Transdermal, Venlafaxine Hydrochloride, Sustained release, Optimization, Factorial design. https://www.ijper.org/development-and-evaluation-of-levofloxacin-based-in-situ-floating-gel-for-enhanc 2026-04-25T07:43:56.027324+00:00 Development and Evaluation of Levofloxacin-Based In situ Floating Gel for Enhanced Gastric Retention 2026-12-06 10.5530/ijper.20260759 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-124.pdf Background: This work focuses on the development and testing of a floating in situ gel system based on sodium alginate that delivers levofloxacin to treat stomach Helicobacter pylori infections. Materials and Methods: As the gelling and gas-forming ingredients, respectively, sodium alginate and calcium carbonate were added in different amounts to create nine distinct formulations. Drug content, pH, viscosity, in vitro gelation, floating behavior and in vitro drug release were all assessed for th Floating in situ gel, Levofloxacin, Helicobacter pylori, Gastro-retentive drug delivery, Sustained drug release. https://www.ijper.org/project-based-learning-with-virtual-laboratories-to-promote-higher-order-thinkin 2026-04-25T07:42:55.680046+00:00 Project-Based Learning with Virtual Laboratories to Promote Higher-Order Thinking Skills to Achieve Competency in Chemical Separation 2026-12-06 10.5530/ijper.20260625 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-52.pdf Background: Higher-order thinking skills become life skills for pharmacists and scientists that are needed in solving scientific problems and can be obtained through implementing appropriate learning models. Objectives: The research aims to implement a project-based learning with virtual laboratory to build higher-order thinking skills as a strategy for achieving chemical separation competence. Materials and Methods: The study was conducted involving 98 undergraduate students, devided into exper Higher-Order Thinking Skills, Project-based learning, Virtual Laboratory, Separation Chemistry, StudentsStudents’ competence. https://www.ijper.org/review-on-exploring-the-combination-effect-of-aldosterone-along-with-plasma-reni 2026-04-25T07:42:39.942194+00:00 Review on Exploring the Combination Effect of Aldosterone along with Plasma Renin with Melatonin and Hydro-Cortisol in Diurnal Rhythm 2026-12-06 10.5530/ijper.20260468 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-33.pdf Aldosterone and plasma renin activity play a role in regulating our blood stress and fluid level while melatonin and cortisol help manage our sleep wake cycles as well as our reaction to stress. These hormones go through fluctuations over the day prompted through elements along with posture, salt intake, pressure levels and sleep patterns. The tricky interplay among the structures governing blood stress, fluid balance, circadian rhythm and pressure response is evident from the interconnectedness RASS, Melatonin, Circadian rhythm, Cortisol, Kidney. https://www.ijper.org/formulation-optimization-and-evaluation-of-barbaloin-loaded-phytosomal-gel-for-t 2026-04-25T07:43:39.075859+00:00 Formulation, Optimization and Evaluation of Barbaloin Loaded Phytosomal Gel for the Treatment of Psoriasis 2026-12-06 10.5530/ijper.20260663 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-101.pdf Background: Phytosomes are one such unique approach gaining popularity due to their capabilities in controlled release and targeted delivery. These advanced herbal formulations significantly enhance the bioavailability of phytochemicals, improving the therapeutic efficacy of Barbaloin by boosting solubility and absorption for the treatment of Psorisis. In this study, phytosomes were prepared using the thin film hydration method with soya lecithin and cholesterol to optimize encapsulation efficie Phytosomes, Bioavailability, Plant Extract, Drug Delivery, Solubility, Therapeutic Efficacy. https://www.ijper.org/the-role-of-epac-in-the-pathogenesis-of-cardiovascular-complications-a-review 2026-04-25T07:42:07.430361+00:00 The Role of EPAC in the Pathogenesis of Cardiovascular Complications: A Review 2026-12-06 10.5530/ijper.20260398 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-1.pdf Cardiovascular disease is a primary cause of mortality and disability and it has long been a focus of clinical and scientific investigation. There is still much to learn about the intricate pathophysiology of cardiovascular disease. The energy needed for circulatory function is provided by mitochondria. Cyclic adenosine monophosphate (cAMP) signalling is directly connected to the mitochondrial action mechanism. cAMP is a ubiquitous second messenger that regulates gene expression, cell shape and Apoptosis, cAMP, Cardiovascular disease, EPAC https://www.ijper.org/evaluation-of-anti-tumour-efficacy-of-liposomes-loaded-with-rubitecan-as-potenti 2026-04-25T07:58:45.20665+00:00 Evaluation of Anti-Tumour Efficacy of Liposomes Loaded with Rubitecan as Potential Antitumor Drug Delivery System 2026-12-06 10.5530/ijper.20264331 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-176.pdf Aim: The present research objective was to characterize the prepared liposomes for in vitro cytotoxicity assay, cellular uptake studies of liposomes, competitive binding assay and hemolytic test. Materials and Methods: The prepared liposomes were assessed for the cellular cytotoxicity of Rubitecan-loaded liposomes on cancer cell linings. Results: The images infer that the uptake of liposomes had a significant time-dependent fusion method for cellular internalization-quantitative analysis of cell Rubitecan, Transferrin, CCK-8, Cellular uptake, Cellular Internalization. https://www.ijper.org/pulmonary-drug-delivery-of-budesonide-in-the-form-of-inhalable-microspheres 2026-04-25T07:58:45.230716+00:00 Pulmonary Drug Delivery of Budesonide in the Form of Inhalable Microspheres 2026-12-06 10.5530/ijper.20261573 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-168.pdf Objectives: Chronic Obstructive Pulmonary Disease (COPD) is a major healthcare issue that is rising and expected to increase in day-to-day life. Our research work focused on developing Dry Powder Inhaler (DPI) microspheres that deliver medication in the form of dry powder into the lungs. Budesonide was used as a drug along with Polycaprolactone which is a biodegradable and biocompatible polymer used in the formulation of microspheres. Due to its non-toxicity with many drugs, it is suitable for c Microspheres, Biodegradable, Inhalation, Polycaprolactone, COPD, Kinetics. https://www.ijper.org/enteric-coated-sustained-release-mucoadhesive-tablet-of-metronidazole-for-target 2026-04-25T07:43:03.182277+00:00 Enteric Coated Sustained Release Mucoadhesive Tablet of Metronidazole for Targeted Colon Delivery: A Formulation and Evaluation Study 2026-12-06 10.5530/ijper.20260414 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-65.pdf Background: Colon-specific Drug Delivery Systems (CDDS) are useful for treating many localized conditions such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome, chronic pancreatitis and colonic cancer. In addition, the colon has the potential to serve as a potential site for the systemic absorption of several drugs used to treat diseases outside of the colon. Drugs, such as proteins and peptides, which are susceptible to degradation under highly acidic gastric conditions, can be Controlled delivery, Enteric-coated, In vitro, Metronidazole, Mucoadhesive. https://www.ijper.org/fabrication-and-characterisation-of-azithromycin-loaded-ethosomes-as-an-advanced 2026-04-25T07:43:47.504107+00:00 Fabrication and Characterisation of Azithromycin-Loaded Ethosomes as an Advanced Vesicular Carriers for Acne Therapy 2026-12-06 10.5530/ijper.20260668 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-112.pdf Aim: This study is aimed to design and evaluate azithromycin-loaded ethosomes as an innovative approach to address the limitations of conventional azithromycin topical dosage forms in the treatment of acne. Materials and Methods: Azithromycin-loaded ethosomes were prepared using the ethanol injection method. Their physicochemical properties were evaluated using techniques like FTIR, DSC, particle size analysis and drug content determination. The formulation was optimized using a central composit Azithromycin, Central-Composite Design, Design of experiment, Ethosomes, P. Acne. https://www.ijper.org/regulatory-pathway-for-genotoxic-impurities-in-europe-us-canada-india-australia 2026-04-25T07:42:47.811552+00:00 Regulatory Pathway for Genotoxic Impurities in Europe, US, Canada, India, Australia and UK 2026-12-06 10.5530/ijper.20260762 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-42.pdf Genotoxic Impurities (GTIs) pose a significant risk to pharmaceutical safety due to their ability to damage DNA and cause cancer-related mutations. Regulatory agencies such as the EMA, USFDA, Heath Canada, CDSCO and TGA have established stringent frameworks to manage these risks, incorporating tools such as Structure-Activity Relationships (SAR) analysis and the Threshold of Toxicological Concern (TTC) to establish safe exposure limits. These frameworks emphasize both proactive impurity profilin Genotoxic Impurities, Pharmaceutical Safety, Regulatory Guidelines, Risk Assessment, Threshold of Toxicological Concern (TTC). https://www.ijper.org/development-and-optimization-of-eletriptan-hydrobromide-sublingual-tablet-using 2026-04-25T07:43:13.396906+00:00 Development and Optimization of Eletriptan Hydrobromide Sublingual Tablet Using Central Composite Design and in vitro Characterization 2026-12-06 10.5530/ijper.20265387 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-74.pdf Background: In the current research, the sublingual tablets were formulated by utilizing a solid dispersion by physical mixture technique using sodium starch glycolate works as a super disintegrant and cyclodextrin works as a solubility enhancer, which can provide a rapid onset of action. Objectives: To prevent first-pass metabolism sublingual drug delivery of an Eletriptan hydrobromide which is considered to be one of the finest surrogate routes of administration. Additionally, it will lead to Sublingual tablet, Super disintegrant, Migraine, Solid dispersion, Solubility enhancement, Rapid disintegration. https://www.ijper.org/investigating-the-amylase-inhibitory-effects-of-adansonia-digitata-l-a-comprehen 2026-04-25T07:58:44.650987+00:00 Investigating the α-Amylase Inhibitory Effects of Adansonia digitata L.: A Comprehensive in vitro and Computational Study 2026-12-06 10.5530/ijper.20261273 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-184.pdf Background: The study explores Adansonia digitata L.s potential in diabetes management through phytochemical and protein analyses. Materials and Methods: Eight identified phytoconstituents, comprising alkaloids, terpenes and steroids, were predicted to modulate diabetic proteins. Network analysis revealed a significant role for compound a (Kaempferol-3-O-rutinoside) in interacting with key molecules. Structural evaluations of α-amylase (PDB: 4W93) using PROCHECK and Chi1-Chi2 highlighted protein Anti-diabetic, Gene Ontology, Kaempferol-3-O-rutinoside, Molecular Docking, Network pharmacology. https://www.ijper.org/formulation-and-characterization-of-clotrimazole-loaded-polymeric-nanoparticles 2026-04-25T07:43:21.778023+00:00 Formulation and Characterization of Clotrimazole Loaded Polymeric Nanoparticles Fabricated by Single Emulsion Evaporation Technique 2026-12-06 10.5530/ijper.20260603 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-83.pdf Aim/background: Utilizing nanotechnology allows us to shrink machinery down to the atomic level, leading to groundbreaking progress in technical innovation. Our most recent efforts concentrated on developing polymeric nanoparticles loaded with clotrimazole to investigate their antifungal abilities. Materials and Methods: Polymeric nanoparticles were synthesized by blending aqueous polyvinyl alcohol with methanolic polycaprolactone and clotrimazole in various ratios. The mixture underwent high-sp Nanoparticles, Nanosystems, Nanocarriers, Nanomaterials, Nanostrutures and Clotrimazole. https://www.ijper.org/global-comparison-of-gene-and-cell-therapy-regulations-a-cross-regional-analysis 2026-04-25T07:42:29.201273+00:00 Global Comparison of Gene and Cell Therapy Regulations: A Cross-Regional Analysis of FDA, EMA, TGA, CSFDA, DCGI, PMDA, IFDA and MFDS 2026-12-06 10.5530/ijper.20260001 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-18.pdf Gene and cell therapies mark a transformative step forward in treating diseases such as cancer, genetic disorders and autoimmune conditions. However, regulatory pathways for these therapies differ worldwide, impacting approval timelines and patient access. This study aims to conduct a cross-regional comparison of the regulatory frameworks for gene and cell therapies across major health agencies, identifying commonalities, differences and opportunities for harmonization. A comparative review of r Cell Therapy, Fast-track Approval, Gene Therapy, Regulatory Framework, Reimbursement https://www.ijper.org/IndJPhaEdRes-60-6059 2026-04-25T09:21:45.519971+00:00 Development and Assessment of Mucoadhesive Buccal Tablets Containing Dapsone: A Pharmaceutical Innovation 2026-04-25 10.5530/ijper.20266059 Objectives: This research involved developing buccal tablets with the drug Dapsone, using varying amounts of three substances: Carbopol 934, Hydroxypropyl Methylcellulose, and Sodium Carboxymethyl Cellulose. Materials and Methods: Twelve different tablet formulations were produced using the direct compression technique. These tablets were tested for various pahysical and chemical attributes, such as hardness, size, weight consistency, drug concentration, tendency to crumble, absorbency, surface Dapsone, Swelling index Mucoadhesion, Buccal tablets. https://www.ijper.org/IndJPhaEdRes-60-1s-151 2026-04-25T08:46:26.355014+00:00 Co-Delivery of Luminescent C-dots and Clonidine Hydrochloride Loaded Nanocarriers for the Effective Management of Glaucoma 2026-04-25 10.5530/ijper.20265229 Aim/Background: Glaucoma is an eye illness associated with Intraocular Pressure (IOP) that, if untreated, can lead to significant vision impairments and potentially complete blindness. Research indicates that eye infections can elevate Intraocular Pressure (IOP) and lead to glaucoma, with anti-glaucoma treatments being ineffective. Combination therapy, which entails the administration of pharmaceuticals alongside nanoscale antibacterial agents, may serve as an effective alternative in this conte Glaucoma, C-dots, Clonidine Hydrochloride, Nanocarrier, Intraocular Pressure. https://www.ijper.org/article/60/3/1284-1292 2026-04-29T11:15:51.569863+00:00 1-(4-Aminophenyl)-3-Morpholinopiperidin-2-One: A Process Related Impurity of Apixaban- An Anticoagulant Drug 2026-04-23 10.5530/ijper.20261932 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1284.pdf Introduction: Apixaban is an anticoagulant drug act by direct inhibition of factor Xa. Apixaban is used for the treatment and prevention of blood clots and stroke in people with nonvalvular atrial fibrillation. In this report, we describe the identification of a process-related impurity observed during the preparation of apixaban, an anticoagulant drug. Objectives: The primary objective of this study was to isolate, purify, and characterize an unknown process impurity observed during the synthes Apixaban, Process-related impurity, Structural alert, Genotoxic impurity, Root cause, investigation https://www.ijper.org/article/60/3/956-966 2026-04-24T05:46:48.619309+00:00 Stimuli-Responsive and Functionalized Nanosponges: Precision Delivery to the Tumor Microenvironment 2026-04-23 10.5530/ijper.20260004 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-956.pdf Background: Cancer, a primary cause of mortality worldwide, is also challenging to treat because of its complexity and diverse forms. WHO has expressed the need for innovative ways to treat this serious problem. There are more than a hundred types of cancers. The hallmark of cancers is metastasis. Although oncology is evolving, a complete cure seems a distant goal. Major reasons include tumor progression, poor drug solubility, weak tumor-targeting, and off-target effects resulting in systemic to Cancer, Functionalized, Nanosponges, Stimuli responsive, Surface modified https://www.ijper.org/article/60/3/1249-1255 2026-04-23T09:41:39.386728+00:00 Simvastatin Promotes Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by Regulating the BMP-2/ Smads Signaling Pathway 2026-04-23 10.5530/ijper.20263499 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1249.pdf Objectives: This study aimed to investigate whether simvastatin could promote the osteogenic differentiation of Bone Marrow Mesenchymal Stem Cells (BMSCs) by modulating the BMP-2/ Smads signaling pathway and to elucidate its underlying mechanisms. Materials and Methods: Rat BMSCs were cultured in vitro and divided into five groups. The control group received no simvastatin intervention, while the other four groups were treated with different concentrations of simvastatin (0.00005 μg/mL, 0.0005 μ Simvastatin, Bone Marrow Mesenchymal Stem Cells (BMSCs), Bone Morphogenetic, Protein-2 (BMP-2), Smads https://www.ijper.org/article/60/3/1037-1045 2026-04-24T05:45:15.495282+00:00 Formulation and Evaluation of Polymeric Ornidazole Floating Microspheres: A Comprehensive Approach 2026-04-23 10.5530/ijper.20266552 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1037.pdf <strong>Aim/Background: Ornidazole is primarily used to treat peptic ulcer. Ornidazole laden floating microspheres were developed to boost bioavailability of the therapeutic moiety and its appropriate therapeutic performance. Materials and Methods: Solvent evaporation approach was utilised to fabricate the gastroretentive floating microspheres using different polymers such as HPMC K100M, Eudragit RS100 and ethyl cellulose. It was also brought to light that the formulation of the ornidazole micro Particulate Drug Delivery, Floating microspheres, Synthetic polymers, Solvent, Evaporation method https://www.ijper.org/article/60/3/1199-1205 2026-04-23T09:41:39.386728+00:00 Investigation of Potential of Oxalis corniculata Through Inhibition of Matrix Metalloproteinases for the Treatment of Skin Photoageing: An in silico Approach 2026-04-23 10.5530/ijper.20266452 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1199.pdf Background: O. carniculata contains bioactive substances called C-glycosyl-flavones that have antioxidant and anti-inflammatory properties. The inhibitory effect of C-glycosyl-flavones of O. carniculata on MMPs was established by in silico molecular modeling approach, that are linked to the collagen degradation pathway. Materials and Methods: Structural flexibility, binding-conformation, binding-free energy, and protein-ligand-interaction profile of Matrix Metalloproteinases (MMPs): MMP1 (966C), MMP, Molecular docking, Phytochemicals, Induced fit docking, Pharmacophore https://www.ijper.org/article/60/3/985-998 2026-04-24T05:44:27.480044+00:00 Optimization and Characterization of Lisinopril Loaded Transdermal Patches by Using Factorial Design 2026-04-23 10.5530/ijper.20261604 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-985.pdf <strong>Background and purpose: This study aimed for systemic and sustained delivery of drug via non-parental route. Materials and Methods: Transdermal patches were prepared by using solvent evaporation method and optimized using 2-factor, 3-level design to investigate the influence of Ethyl Cellulose and HPMC on their tensile strength and drug release. Results: Optimized transdermal patches have shown uniform drug distribution with tensile strength 3.54±0.40 kg/mm2 and in vitro release 94.41±8. Transdermal Patches, Sustained Delivery, Solvent Evaporation Method, Statistical, Experimental Designs, Factorial Design, Lisinopril https://www.ijper.org/article/60/3/1143-1151 2026-04-23T09:41:39.386728+00:00 Effect of Curcumin and Dioscorea alata L. On Aniline Induced Spleen Toxicity in Rats 2026-04-23 10.5530/ijper.20261638 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1143.pdf Background: In this investigation, the consequences of standardized ethanolic extracts of curcumin and Dioscorea alata L. To assess their therapeutic potential individually and together in spleen poisoning caused by aniline in rats, focusing on hematological, physiological parameters, serum parameters, antioxidant parameter, and histopathological changes over a 30-day period. Materials and Methods: The investigation included six Wistar rats of both sexes per group, weighing between 200-270 g. Fo Curcumin, Dioscorea alata, Spleen toxicity, oxidative stress, hematological parameters https://www.ijper.org/article/60/3/1070-1080 2026-04-23T09:41:39.386728+00:00 Psoralen Attenuates Rheumatoid Arthritis through Inhibition of the IL-1β/IL-18/NLRP3 Inflammasome Axis 2026-04-23 10.5530/ijper.20261577 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1070.pdf Background: Psoralen, a naturally derived compound, is known for its anti-inflammatory properties and thus it is essential to evaluate its effects on inflammatory pathways in Rheumatoid Arthritis (RA). Aim: To assess the anti-RA potential of psoralen by evaluating its effects on protein denaturation, cytokine and inflammasome inhibition, and cell proliferation in RA models and confirm its molecular interactions using molecular docking and simulations. Materials and Methods: Psoralen was tested f Cytokines, IL-18, IL-1β, Inflammasome, NLRP3, Psoralen, Rheumatoid Arthritis https://www.ijper.org/article/60/3/1180-1188 2026-04-23T09:41:39.386728+00:00 Neuroprotective Effects of Conessine in Beta-Amyloid- Induced SH-SY5Y Cells In vitro 2026-04-23 10.5530/ijper.20263491 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1180.pdf Objectives: Alzheimer’s Disease (AD) is a brain disorder that affects the memory and thinking ability of the patient, characterised by beta-amyloid (Aβ) plaque accumulation, oxidative stress, impaired autophagy, and neuronal death, leading to cognitive decline. Current treatment for AD is limited to symptomatic relief, which highlights the demand for the discovery of newer drugs. Conessine, a steroidal alkaloid derived from Holarrhena antidysenterica, has demonstrated potential neuroprotective a Alzheimer’s Disease, Conessine, Beta-amyloid, Neuroprotection, Autophagy, Oxidative Stress, NRF2, HMOX1 https://www.ijper.org/article/60/3/1256-1267 2026-04-27T06:06:07.78497+00:00 TSH Suppression Induces Anxiety- and Depression-like Behaviors in Rats, With Hippocampal 5-HT Loss, Notch Activation, and a Neurogenesis-Apoptosis Imbalance 2026-04-23 10.5530/ijper.20264130 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1256.pdf Background: TSH suppression is widely used in thyroid cancer management; however, its neurobehavioral consequences are not well understood. Objectives: To evaluate the impact of TSH suppression on emotion-related behaviors, thyroid axis hormones, hippocampal serotonin (5-HT) levels, neurogenesis, Notch signaling, and apoptosis in a rat model. Materials and Methods: Rats were assigned to three groups: blank control, TSH replacement, and TSH suppression. TSH suppression was induced using total thy 5-HT, Bax/Bcl-2, Neurogenesis, Notch, Open field, Tail suspension, TSH suppression https://www.ijper.org/article/60/3/1206-1217 2026-04-29T10:12:03.627465+00:00 Decoding the Anticancer Mechanism of Action of Kaempferol in Liver Cancer Cells via Transcriptomics, Network Pharmacology, Molecular Docking, Dynamics Simulations, and in vitro Validation 2026-04-23 10.5530/ijper.20262120 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1206.pdf Background: Kaempferol, a dietary flavonoid with proven antioxidant and antiinflammatory properties, has garnered significant interest in cancer research for its ability to modulate multiple oncogenic pathways, making it a compelling candidate for multitargeted therapy in addressing the considerable health burden of liver cancer. Objectives: To elucidate the therapeutic potential of kaempferol through network pharmacology, and in vitro experimental methodology. Materials and Methods: The pharmac Natural Products, Bioinformatics, Network Pharmacology, Liver cancer, Molecular, Docking, Apoptosis https://www.ijper.org/article/60/3/1293-1303 2026-04-23T09:41:39.386728+00:00 Analytical Quality by Design Enabled HPTLC Method for Estimation of Phytoconstituents Andrographolide, Piperine and Quercetin in Nilavembu Kudineer 2026-04-23 10.5530/ijper.20261651 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1293.pdf Background: This work outlines a sensitive, cost-effective, reliable and ecofriendly novel AQbD approach based HPTLC for the simultaneous determination of standard samples of Andrographolide (A), Piperine (P) and Quercetin (Q) and in Nilavembu Kudineer. The dependent variable retardation factor was considered as critical method response for each of the three phytomarkers whereas the independent variables, methanol %, saturation time and development distance were regarded as critical method param Analytical QbD, Andrographolide, Piperine, Quercetin, Nilaveembu Kudineer, HPTLC https://www.ijper.org/article/60/3/1013-1020 2026-04-24T05:44:44.679104+00:00 In vitro Characterisation of an Injectable Composite Graft Material Synthesised from Collagen Extracted from Fish Scales and Eggshell-Derived Hydroxyapatite 2026-04-23 10.5530/ijper.20261992 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1013.pdf <strong>Aim/Background: Collagen and hydroxyapatite have been used as scaffold for bone repair encouraging cell adhesion and growth. Composites synthesized from hydroxyapatite and collagen mimic biomechanical properties of natural bone. Extensive efforts have been made to fabricate graft materials from natural sources to mimic biochemical and biomechanical properties of natural bone. The present study is aimed to synthesise a composite graft from eggshell derived hydroxyapatite and fish collagen Bone graft, Composite, Eggshell, Hydroxyapatite, Fish Collagen, Characterisation https://www.ijper.org/article/60/3/1326-1334 2026-04-23T09:41:39.386728+00:00 The Mediating Role of Sense of Meaning in Life and Negative Cognitive Emotions: An Assessment of the Impact of Stressful Events on the Mental Health of Cancer Patients During the COVID-19 Pandemic 2026-04-23 10.5530/ijper.20261699 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1326.pdf Background: The COVID-19 pandemic posed significant challenges for cancer patients, intensifying psychological stress and compromising mental health. This study examined the relationships between stressful life events, sense of meaning in life, negative cognitive emotions, and mental health outcomes. Materials and Methods: A mediation analysis was conducted to explore both direct and indirect pathways, with cognitive emotions and sense of meaning of life acting as mediators. Data collected from COVID-19 Pandemic, Cancer Patients, Psychological Stress, Cognitive Emotions, Sense of Meaning https://www.ijper.org/article/60/3/1304-1310 2026-04-23T09:41:39.386728+00:00 Bioanalytical Method Development and Validation of an LC-MS/MS Method for the Quantitation of Fruquintinib in Rabbit Plasma 2026-04-23 10.5530/ijper.20262575 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1304.pdf Aim: An LC-MS/MS method is needed to accurately measure the concentration of Fruquintinib in a biological sample. This method should be both specific and sensitive. Materials and Methods: The processed materials were separated using a Hypersil ODS C18 column (50 mm × 4.6 mm) 3.5 µm with a mobile phase of acetonitrile, methyl alcohol, and 0.1% HCOOH in the proportion of 20:70:10. The moveable solvent system was measured using a column with 0.7 mL/ min rate of flow. The drug and Internal Standard Bio-Analytical Method, Fruquintinib, ICH Validation, LC-MS/MS Method, Quantitative, Determination, Rabbit Plasma, VEGFR https://www.ijper.org/article/60/3/937-945 2026-04-23T09:41:39.386728+00:00 Newer Pedagogical Methods for Teaching and Learning in Pharmaceutical Education 2026-04-23 10.5530/ijper.20263402 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-937.pdf Pharmaceutical education has undergone a paradigm shift from traditional didactic instruction to more interactive, learner-centered approaches. This review explores modern pedagogical methods and presents real-world case studies demonstrating their application in pharmacy education. Lecture-based learning was shown to enhance foundational knowledge delivery, while inquiry-based and project-based strategies improved problem-solving and research aptitude. For instance, kinesthetic learning in medi Pharmaceutical Education, Active Learning, Pedagogical Innovation, Case-Based, Teaching, Problem-Solving Skills https://www.ijper.org/article/60/3/1061-1069 2026-04-23T09:41:39.386728+00:00 Optimized Formulation of Carvedilol Fast-Dissolving Tablets Using Modified Super disintegrants: Breaking Solubility Barriers of BCS Class II Drugs 2026-04-23 10.5530/ijper.20261525 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1061.pdf Background: The BCS Class-II faces major challenge, low solubility and poor bioavailability issues. Carvedilol, an anti-hypertensive drugs, has a bioavailability 20-25%. Objectives: This research focuses on the development of fast dissolving tablets for Carvedilol (CARV), utilizing sorghum starch modified with humic acid as a novel superdisintegrant through factorial design to achieve rapid drug dissolution, bioavailability and patient compliance. Materials and Methods: Sorghum starch was isolat Bioavailability, Fast Dissolving Tablets, Sorghum starch, Starch humate, Superdisintegrant https://www.ijper.org/article/60/3/999-1012 2026-04-23T09:41:39.386728+00:00 Development and Optimization of Memantine-PEGylated PLGA Liposomal Formulation for Nose-to-Brain Delivery in Alzheimer's Disease: A Quality-by-Design (QbD) Approach 2026-04-23 10.5530/ijper.20261979 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-999.pdf Aim: This study aimed to develop and evaluate Memantine-PEGylated-PLGA Liposomal Formulation for Nose-to-Brain Delivery in Alzheimers Disease: A Quality-by-Design (QbD) Approach. Background: Alzheimer’s disease is a progressive neurodegenerative disorder characterized by neuronal degeneration and the accumulation of β-amyloid plaques and hyperphosphorylated tau proteins. Conventional drug delivery systems face significant challenges in achieving effective brain targeting due to the presence of t Alzheimer’s disease, Beta-amyloid plaque, Quality by Design approach, Entrapment, Efficiency, PEGylated liposomes https://www.ijper.org/article/60/3/918-924 2026-04-23T09:41:39.386728+00:00 The Interplay between Traumatic Brain Injury, Cocaine Abuse, and Genetic Mutations in the Development of Parkinsons Disease: A Review 2026-04-23 10.5530/ijper.20262583 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-918.pdf Parkinson's Disease (PD) is a neurodegenerative disorder characterized by the depletion of dopamine neurotransmitters and receptors. Although the etiology of PD is multifactorial, emerging evidence suggests that Traumatic Brain Injury (TBI), cocaine abuse, and genetic mutations may contribute to the development and progression of PD. This review summarizes the current understanding of the interplay between TBI, cocaine abuse, and genetic mutations in DA homeostasis in PD. Here, we discuss the mo Cocaine abuse, Dopamine, Genetic mutation, Parkinson's disease, Traumatic brain, injury https://www.ijper.org/article/60/3/925-936 2026-04-24T09:02:24.471672+00:00 Utilizing Biomimetic Polymers for Innovations in Drug and Gene Delivery 2026-04-23 10.5530/ijper.20262917 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-925.pdf Biomimetic polymers are increasingly being explored in advanced drug and gene delivery research due to their ability to imitate the structure and function of natural biological systems. Increased biocompatibility, targeted delivery, and controlled release (with time-dependent release kinetics) make them ideally suited for therapeutic applications. These polymers imitate the features of cell membranes, proteins and other biological entities, and have shown greater biocompatibility, targeted deliv Biological Molecule and amp, Biomimetic Polymer, Gene Delivery, Structure https://www.ijper.org/article/60/3/1159-1168 2026-04-23T09:41:39.386728+00:00 Synthesis, Structural Properties and Antibacterial Activity of Vorinostat Loaded on Carbon Nanotubes or Iron Oxide Nanoparticles 2026-04-23 10.5530/ijper.20261673 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1159.pdf Background: In this work, Carbon Nanotubes (CNTs) and Iron Oxide Nanoparticles (IONPs) were successfully synthesized and their antibacterial activity were evaluated against Staphylococcus aureus (Gram-positive) and Pseudomonus aeruginosa (Gram-negative). Vorinostat, (SAHA) is a histone deacetylase inhibitor has recently shown the potential as an antibacterial agent through the genewration of Reactive Oxygen Species (ROS). Materials and Methods: Vorinostat (SAHA) was synthesized using conventiona SAHA, Carbon Nanotube (CNTs), Iron Oxide Nanoparticles, Antibacterial Activity, Drug Delivery https://www.ijper.org/article/60/3/1113-1130 2026-04-24T05:59:59.006711+00:00 HPLC-Based Phytochemical Profiling and Untargeted Proteomics with Cytotoxicity Assessment of Ethanolic Extracts of Punica granatum on MCF-7 and C6 Cancer Cell Lines 2026-04-23 10.5530/ijper.20261722 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1113.pdf <strong>Background and Aim: To perform HPLC-based phytochemical profiling and untargeted proteomic analysis of ethanolic extracts from Punica granatum, and evaluate their cytotoxic activity against MCF-7 and C6 cancer cell lines. The study aims to identify key bioactive compounds in the extract, analyze their molecular mechanisms through proteomic changes, and assess their potential anticancer properties. Materials and Methods: Pomegranate peels extracts were prepared using ethanol analyzed for Breast Cancer, Punica granatum, Glioblastoma, HEK Cell lines, Metabolomics, LC-HRMS, RP-HPLC https://www.ijper.org/article/60/3/1233-1240 2026-04-29T10:38:47.623112+00:00 Pro-inflammatory Cytokine TNF-α Reduces Matrix Calcification in Papillary Thyroid Carcinoma 2026-04-23 10.5530/ijper.20263458 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1233.pdf Aim/Background: Tumor Necrosis Factor-α (TNF-α) is a key pro-inflammatory cytokine involved in immune regulation, chronic inflammation, and tumor progression. However, its role in the calcification process of thyroid malignancies, particularly Papillary Thyroid Carcinoma (PTC), remains unclear. To investigate the effect of TNF-α on matrix calcification and the invasive behavior of papillary thyroid carcinoma cell lines. Materials and Methods: Two PTC cell lines, TPC-1 and BCPAP, were treated wit Thyroid papillary carcinoma, Calcification, Inflammatory cytokines https://www.ijper.org/article/60/3/1189-1198 2026-04-23T09:41:39.386728+00:00 Phytochemical Profiling and Evaluation of Cytotoxic Potential of Cucumis prophetarum L. Fruit Extract 2026-04-23 10.5530/ijper.20262051 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1189.pdf Objectives: The present study examined phytochemical composition of ethanolic extract and evaluated cytotoxic properties of Cucumis prophetarum L. Materials and Methods: Phytochemical composition of extract was evaluated by GC-MS and screened for cytotoxic activity by MTT assay. The human cancer cell-lines including MCF7, A2780, HT29, and Normal Fetal Lung Fibroblasts (MRC5), used to determine cytotoxicity and selectivity index of the extract. Results and Discussion: Fatty acid esters (43.74%), Cucumis prophetarum L, GC-MS, Phytochemical, Cytotoxic, Selectivity index, Apoptosis https://www.ijper.org/article/60/3/1026-1036 2026-04-24T05:45:00.842436+00:00 Bile Acid-Based Lipid Nanoparticles to Ameliorate Oral Bioavailability of Gliclazide: A Response Surface Methodology Approach 2026-04-23 10.5530/ijper.20263497 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1026.pdf <strong>Background/Objectives: Gliclazide is one of the commonly used oral anti-diabetic agents. It suffers limited and variable bioavailability due to poor solubility and intra- and inter-subject variability. The prime objective of this work was to upgrade its oral bioavailability via enhancing the solubility and dissolution rate by making lipid-based bile nanoparticles. Materials and Methods: Gliclazide loaded nanoparticles made up of lipids and bile salts were developed by emulsion solvent ev Gliclazide, Solubility, Bioavailability, Lipid-based nanoparticles, Response surface, methodology https://www.ijper.org/article/60/3/1276-1283 2026-04-23T09:41:39.386728+00:00 Crafting Cancer-Fighting Wonders: Synthesis, Characterization, and Evaluation of a Novel Thiazole Derivative Targeting EGFR 2026-04-23 10.5530/ijper.20267061 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1276.pdf Aim: The development of novel thiazole derivatives, namely PVS 3.1, 3.2, 3.3, and 3.4, marks a significant advancement in the field of anticancer drug discovery. These compounds were synthesized using an efficient, time-saving synthetic route that overcomes the limitations of conventional methods, which are often laborious, time-intensive, and costly. The new approach reflects a considerable step forward in the streamlining of drug development processes. Materials and Methods: The cytotoxic pote Thiazole derivatives, Anticancer activity, MTT assay, EGFR tyrosine kinase, L858R/, T790M mutation, Drug resistance, Cytotoxicity, Targeted therapy, Cancer cell lines, Dual-mode, action https://www.ijper.org/article/60/3/946-955 2026-04-27T05:49:25.940728+00:00 Therapeutic Repurposing Strategies for Cardiovascular Disease Management 2026-04-23 10.5530/ijper.20264229 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-946.pdf Background: Anti-oxidants are vital in maintaining cellular homeostasis by neutralizing Reactive Oxygen Species (ROS) and mitigating oxidative stress. This review aims to explore their role in disease modulation, with a particular focus on cardiovascular disorders, including myocardial infarction and atherosclerosis. Materials and Methods: A comprehensive review of peer-reviewed literature was conducted to assess the biochemical mechanisms, efficacy, and clinical relevance of both natural and sy Anti-oxidants, Reactive Oxygen Species, Oxidative Stress, Biomarkers, Cardiovascular, Diseases https://www.ijper.org/article/60/3/1052-1060 2026-04-24T05:45:48.442823+00:00 Pioneering Prolonged Release: A Novel Pellet-Based Approach to Anti-Anginal Therapy of Ranolazine 2026-04-23 10.5530/ijper.20261515 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1052.pdf Aim: Angina is a clinical syndrome with symptoms attributed to myocardial ischaemia. There are many class of drugs which are used to manage it, among such is ranolazine which acts by inhibiting late Na+ current. Ranolazine is used for the treatment of recurrent angina. So, the aim of the present work was to develop prolonged release pellets incorporated into capsules. Materials and Methods: In the present study, pellets were prepared by the Extruder and Spherodizer equipment using polymer Eudrag Ranolazine, Sustained Release Pellets, Extrusion and Spheronization, Pelletization https://www.ijper.org/article/60/3/1152-1158 2026-04-29T11:12:55.25933+00:00 Xing Xia Di Tan Decoction Enhances Microwave Ablation and Chemotherapy in Lung Cancer: Molecular Insights from Network Pharmacology 2026-04-23 10.5530/ijper.20263058 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1152.pdf <strong>Background/Aim: Non-small cell lung cancer (NSCLC) accounts for most lung cancer cases and remains a major health burden. Many elderly patients cannot tolerate targeted or immune therapies, or develop resistance, underscoring the need for alternative strategies. This study evaluated the synergistic effects of Xing Xia Di Tan Decoction (XXDTD), a Traditional Chinese Medicine (TCM) formula, with microwave ablation (MWA) and chemotherapy, and explored its molecular mechanisms. Materials and Lung cancer, Xing Xia Di Tan Decoction, Microwave ablation, Chemotherapy, Network, pharmacology, RXRA, BAX https://www.ijper.org/article/60/3/1241-1248 2026-04-23T09:41:39.386728+00:00 Targeting PARP1 by Small Molecule Drugs for the Therapeutics of Gynaecological Cancers 2026-04-23 10.5530/ijper.20261925 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1241.pdf Background: In gynaecological cancers like ovarian, endometrial, and cervical cancer, where DNA damage repair mechanisms are frequently dysregulated, targeting PARP1 offers a targeted therapeutic approach. Materials and Methods: This study was aimed to identify the small molecules for the inhibition of PARP1 using bioinformatics and in vitro methods. Screening and molecular docking of a diverse ligand library identified Apigenin as a potential Results: PARP1 inhibitor, exhibiting strong binding Apigenin, Gynaecological Cancers, HeLa-229, Molecular Docking, PARP1, Inhibition https://www.ijper.org/article/60/3/1081-1095 2026-04-23T09:41:39.386728+00:00 Phytochemical Profiling and Biological Assessment of Curcuma aromatica Using UPLC-MS, In silico, and In vitro Approaches for Acne Treatment 2026-04-23 10.5530/ijper.20263322 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1081.pdf Background: Acne vulgaris is a dermatological condition involving sebaceous gland dysfunction and is characterized by excess sebum secretion, follicular hyperkeratinization, bacterial growth, and inflammation. Curcuma aromatica (C. aromatica), commonly known as wild turmeric, is a medicinal rhizome rich in bioactive phytochemicals. It is a potential source of anti-acne agents due to its antimicrobial, anti-inflammatory, and antioxidant properties. Materials and Methods: Extraction of C. aromatic Acne Vulgaris, Antioxidant, Curcuma aromatica, HRLC-MS/MS, In silico, Propionibacterium acnes https://www.ijper.org/article/60/3/967-984 2026-04-23T09:41:39.386728+00:00 Exploring the Impact of Zed Certification on Manufacturing Excellence and Environmental Responsibility 2026-04-23 10.5530/ijper.20262556 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-967.pdf The ZED (Zero Defect Zero Effect) Certification is an initiative aimed at enhancing the performance and sustainability of Small and Medium Enterprises (SMEs) in India. It focuses on promoting high-quality production, minimizing defects, and reducing environmental impact. The certification encourages businesses to implement global best practices while fostering improvements in efficiency, quality, and social responsibility. The ZED Certification process is structured in multiple stages, allowing Zero Defect Zero Effect, SME Sustainability, Quality Production, Environmental, Responsibility https://www.ijper.org/article/60/3/1046-1051 2026-04-23T09:41:39.386728+00:00 Formulation, Developing, and Assessment of Vitamin D3-Enriched Microsphere Cream for Anti-Aging Therapy 2026-04-23 10.5530/ijper.20261523 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1046.pdf Background: The aim of this paper is to describe the advancement in dermal drug delivery employing microspheres as the method, focusing on the synthesis of microspheres by solvent evaporation technique to be formulated in to a cream base foundation. Materials and Methods: The microspheres were prepared through a solvent evaporation method followed by incorporation into a cream base enriched with Vitamin D3 (Cholecalciferol) to improve the drug release rate. In vitro/ex vivo analytical practices Anti-aging, Cosmetics, Microsphere, Skin Care, Vitamin D3 https://www.ijper.org/article/60/3/1311-1325 2026-04-23T09:41:39.386728+00:00 Integration of Green Analytical Chemistry and Quality by Design Approach for Systematic Development of Stability-Indicating RP-HPLC Method for Estimation of Guanfacine 2026-04-23 10.5530/ijper.20262597 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1311.pdf Background: Guanfacine, a phenylacetyl-guanidine derivative, has gained pharmaceutical significance due to its therapeutic applications. A stability-indicating, Quality by Design (QbD)- based RP-HPLC method was developed and validated for its quantification in bulk drugs to meet its growing demand. Additionally, its environmental sustainability was assessed using the AGREE tool to ensure compliance with Green Analytical Chemistry (GAC) principles. Materials and Methods: The RP-HPLC method was op Guanfacine, Quality by Design, Green Chemistry, AGREE Tool, RP-HPLC, Box-Behnken, Design https://www.ijper.org/article/60/3/1268-1275 2026-04-23T09:41:39.386728+00:00 Exploring the Mechanism of Isoliquiritigenin on Lung Cancer Based on Network Pharmacology and Molecular Docking 2026-04-23 10.5530/ijper.20260503 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1268.pdf Objectives: This study aims to explore how Isoliquiritigenin (ISL) combats lung cancer by using network pharmacology and molecular docking techniques. Materials and Methods: We used multiple databases to find ISL-related targets and lung cancer-associated genes, followed by enrichment analysis using the Cluster Profiler package. Network analysis via the STRING database and Cytoscape illuminated the protein-protein interaction landscape. The Kaplan-Meier plotter evaluated the prognostic relevance ISL, Isoliquiritigenin, Lung Cancer, Molecular Docking, Network Pharmacology, Protein-Protein Interactions https://www.ijper.org/article/60/3/1224-1232 2026-04-23T09:41:39.386728+00:00 A Glimpse of the Interaction between N-Nitrosamines and HPV E5 in Rodent Cell Transformation 2026-04-23 10.5530/ijper.20263287 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1224.pdf Background: A few epidemiologic surveys and experimental studies observed the synergistic carcinogenic effect of nitrosamines and High-Risk Human Papillomavirus (HPV) in partial digestive tract cancers. They mainly focused on the co-carcinogenesis of HPV E6 and E7 in cancer development. HPV E5 plays an important role in early-stage cancer but has limited capacity as an independent carcinogen. Objective: To investigate whether nitrosamines enhance the carcinogenesis of E5, a rapid in vitro rodent Human Papillomavirus16, E5 oncoprotein, N-nitrosamines, BALB/c 3T3 cell, Synergy, effect, Carcinogenicity https://www.ijper.org/article/60/3/1169-1179 2026-04-23T09:41:39.386728+00:00 Monoamine Oxidase Inhibition Activity of Ziziphus jujube Mill. Fruit Extracts in Chronic Unpredictable Stress Rats 2026-04-23 10.5530/ijper.20262858 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1169.pdf Background: In the current healing synopsis, no allopathic drug is available that can renew the pathogenic development of neurodegenerative conditions, to a degree of concavity, a shift towards everyday remedies is needed. Ziziphus jujube Mill., Rhamnaceae, is a medicinal plant with flavonoids and tannins that augments depressing conditions. Aim: The current work evaluated the therapeutic potential of the ethanolic and water extract of Ziziphus jujube for MAO inhibition in the chronic unpredicta Antidepressant, Chronic Unpredictable Stress, Lipid peroxidation, Monoamine, oxidase inhibitors, Ziziphus jujube Mill https://www.ijper.org/article/60/3/1218-1223 2026-04-29T11:14:14.632971+00:00 Inhibition of miR-224 Repressed Cell Growth, Migration and Invasiveness in Gastric Cancer 2026-04-23 10.5530/ijper.20263262 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1218.pdf Aim/Background: MiR-224 has been reported to be associated with many cancers, however, the role of miR-224 in gastric cancer was unclear. Materials and Methods: In the present study, we first used RT-PCR to detect miR-224 level in gastric cancer fresh tissue. Then we performed miR-224 inhibitor transfection in gastric cancer cells, and MTT, cell invasion and migration and colony formation were performed to explore the role of miR-224 in gastric cancer in vitro. Results: The results showed that t miR-224, Growth, Migration, Invasiveness, Gastric Cancer https://www.ijper.org/article/60/3/1096-1112 2026-04-23T09:41:39.386728+00:00 Anticancer and Apoptotic Effects of Juglone in Ovarian Carcinoma: An Integrated Computational and Experimental Study 2026-04-23 10.5530/ijper.20261749 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1096.pdf Background: Juglone, a naturally occurring naphthoquinone, has been recognized for its potential anticancer properties. Recent advances in network pharmacology allow for the systematic elucidation of complex molecular interactions in disease, particularly in oncology. Objectives: This study aimed to integrate network pharmacology, in silico molecular docking and experimental validation to demonstrate the anticancer potential of juglone in OVCAR-3 human ovarian carcinoma cells. Materials and Meth Cell Cycle Arrest, Juglone, Molecular Docking, Network Pharmacology, Ovarian, Cancer https://www.ijper.org/article/60/3/1131-1142 2026-04-23T09:41:39.386728+00:00 Anticancer Activity of Angelica dahurica Used in Traditional Chinese Medicine (TCM) against Human Breast Cancer Cells: Mechanistic Evaluation by Using an Integrated Approach of Network Pharmacology, Computational Molecular Docking and Experimental Assays 2026-04-23 10.5530/ijper.20262481 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1131.pdf Background: Breast Cancer (BC) remains a major global health challenge, necessitating novel treatment approaches to improve therapeutic outcomes. Angelica dahurica, a traditional medicinal plant, contains phytochemicals with potential anticancer properties, offering a promising avenue for investigation. Aim: This study evaluates the anticancer potential of Angelica dahurica extract against BC by integrating in silico network pharmacology with in vitro experimental validation, focusing on the mod Angelica dahurica, Network-Pharmacology, Breast Cancer, Gene-ontology Enrichment Analysis, Molecular Docking, Cytotoxicity https://www.ijper.org/article/60/3/1335-1341 2026-04-23T09:41:39.386728+00:00 Assessment of Clinical Outcomes for Tuberculosis Patients in Makassar, South Celebes; Focusing on Quality of Life and the Efficacy of Antituberculosis Treatment 2026-04-23 10.5530/ijper.20261530 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1335.pdf Background: Tuberculosis is a highly prevalent infectious illness of the respiratory tract in Indonesia. Furthermore, tuberculosis management is incorporated into the national program of the Ministry of Health to diminish the incidence rate and enhance the recovery rate. Nonetheless, numerous individuals continue to disregard tuberculosis treatment, mainly due to the extensive array of medications required for sufferers. Objectives: This study will investigate the alterations in the quality of l Antituberculosis, Quality of life, Therapeutic efficacy, Tuberculosis https://www.ijper.org/article/60/3/1021-1025 2026-04-23T09:41:39.386728+00:00 QbD Approach for Developing Fast-Dissolving Films of Ondansetron Hydrochloride using HPMC E5 and Primojel 2026-04-23 10.5530/ijper.20262850 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1021.pdf Objectives: Purpose of present research study was to use Ondansetron to develop a film that dissolves quickly. Materials and Methods: HPMC E5 and Primojel were used in different ratios to prepare oral dissolving films. Technique used to prepare films was solvent casting. Results: Because of HPMC E5 cps, the film had an excellent thickness. The plasticizer glycerin showed good folding durability, elongation percentage, and tensile strength. Formulation F7 showed better oral sensation, folding cap Ondansetron, HPMC E5, Primojel, 3² Factorial Design, solvent-casting, Fast-Dissolving, Film, Disintegration Time https://www.ijper.org/in-silico-and-in-vitro-investigation-of-osteogenesis-potentiality-of-smilax-chin 2026-04-23T09:41:43.143625+00:00 In silico and in vitro Investigation of Osteogenesis Potentiality of Smilax china Hydro Alcoholic Root Extract on Human Osteoblast-like Cell Line (Saos2)-A Novel Approach 2026-03-10 10.5530/ijper.20263810 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-805.pdf Background: Osteoporosis is a skeletal illness characterised by the breakdown of bone tissue's micro-architecture, which increases the risk of fractures by making bones more brittle. Nowadays, the herbal based therapies gaining more attraction towards osteoporosis for its low risk of side effects. Aim: The goal of this study is to prove Smilax china root extract’s osteogenesis ability towards osteoblast like cell line Saos2. Materials and Methods: Cytotoxicity parameters such as tetrazolium-base Alkaline phosphatase, Mineralisation, Osteogenesis, Osteoporosis, Saos2 cells, Smilax china https://www.ijper.org/flavonoid-ameliorates-anxiety-in-high-fat-high-fructose-diet-induced-insulin-res 2026-04-23T09:41:43.143625+00:00 Flavonoid Ameliorates Anxiety in High Fat High Fructose diet Induced Insulin Resistance in Rats 2026-03-10 10.5530/ijper.20263878 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-563.pdf Objectives: Literature review revealed that intake of high fat diet had a likelihood of causing metabolic syndrome and might be involved in causing anxiogenic symptoms. The current study was drafted to appraise hesperidin effect (bioflavonoid) in delaying the progression of anxiety-like symptoms caused by intake of High-Fat High-Fructose Diet (HFHFrD) in male albino Wistar rats. Materials and Methods: Rats were fed with HFHFrD for the induction of insulin resistance (Metabolic syndrome). The rol Insulin Resistance, Neuroinflammation, Anxiety, Metformin, Hesperidin and Exercise https://www.ijper.org/unmasking-the-therapeutic-potential-of-a-bio-enhanced-phloretin-formulation-form 2026-04-23T09:41:43.143625+00:00 Unmasking the Therapeutic Potential of a Bio-enhanced Phloretin Formulation: Formulation, Characterization, and Evaluation 2026-03-10 10.5530/ijper.20264165 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-669.pdf Introduction: Phloretin (PHL, 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl) propan-1- one), is a naturally occurring dihydrochalcone, exclusively found in apple fruit peels, leaves, and Manchurian apricots. It has tremendous benefits as an antioxidant, anti-inflammatory, neuroprotective and anti-cancer agent but its Bioavailability (BA) and penetration across the Blood-Brain Barrier (BBB) is limited as it is a BCS class II drug, thereby hindering its therapeutic applications. Materials and Meth Phloretin, Solid dispersion, Antioxidant, Pharmacokinetics, Melt-fusion https://www.ijper.org/optimization-of-ganciclovir-loaded-nanoparticles-for-ocular-delivery-by-utilizin 2026-04-23T09:41:43.143625+00:00 Optimization of Ganciclovir-Loaded Nanoparticles for Ocular Delivery by Utilizing Box-Behnken Design 2026-03-10 10.5530/ijper.20262668 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-826.pdf Aim: The study aimed to optimize Ganciclovir-loaded nanoparticles for ocular delivery by evaluating the relationship between experimental data and Design factors. Materials and Methods: The nanoparticles were developed using the ionic gelation method. A 3-level, 3-factor Box-Behnken Design (BBD) was used for the optimisation process. Selecting the concentrations of chitosan, Sodium Tripolyphosphate (STPP) and sonication time as the independent variables. Entrapment efficiency, Drug release and D Nanoparticles, Box-Behnken design, Ganciclovir, Ocular delivery, Ionic gelation https://www.ijper.org/artificial-intelligencemachine-learning-in-pharma-analysis-and-quality-control-a 2026-04-23T09:41:43.143625+00:00 Artificial Intelligence/Machine Learning in Pharma Analysis and Quality Control: A Real-World Upgrade 2026-03-10 10.5530/ijper.20264489 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-375.pdf Pharmaceutical analysis and quality control are now being transformed by Artificial Intelligence (AI) and Machine Learning (ML) through remarkable improvement in speed, accuracy, reliability, robustness of analysis methods. This review is to explore the integration of these tools into raw material inspection, in-process monitoring, and finished product analysis. A comprehensive survey of published literature, regulatory documents, and case studies was conducted. Key AI/ ML paradigms Supervised, Artificial intelligence (AI), Machine learning (ML), Pharmaceutical Analysis and Quality Control, Process Analytical Technology (PAT) https://www.ijper.org/evaluation-of-anti-arthritic-effect-of-red-sandalwood-and-curcumin-combination-o 2026-04-23T09:41:43.143625+00:00 Evaluation of Anti-Arthritic Effect of Red Sandalwood and Curcumin Combination (Orthorev Oil)® on Topical Application in Rats 2026-03-10 10.5530/ijper.20262483 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-638.pdf Background: Arthritis, a common and debilitating condition characterized by joint inflammation, pain, and stiffness, affects millions of individuals worldwide. The standard treatment for arthritis is effective, but often comes with significant side effects and may not be suitable for long-term use. Aim: To evaluate the anti-arthritic effects of topical application of Orthorev Oil ® containing a combination of red sandalwood and curcumin in a rat model of arthritis. Materials and Methods: Wistar Topical, Rheumatoid arthritis, Paw volume, Red sandalwood, Curcumin https://www.ijper.org/synthesis-and-evaluation-of-mutual-prodrug-of-mefenamic-acid-and-etodolac-with-s 2026-04-23T09:41:43.143625+00:00 Synthesis and Evaluation of Mutual Prodrug of Mefenamic Acid and Etodolac with Sesamol for the Treatment of Alzheimer's Disease 2026-03-10 10.5530/ijper.20261831 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-627.pdf Background: Epidemiological and clinical trial data suggest that NSAIDs can be used for managing Alzheimer's disease. This research area began with the observation of reduced incidence and progression of Alzheimer's disease in arthritic patients who are on NSAID medication. Objectives: This study focuses on the mutual prodrug of Mefenamic acid and Etodolac with Sesamol for treating Alzheimer's disease. Materials and Methods: The mutual prodrugs of NSAIDs with Sesamol were synthesized using the S Alzheimer’s disease, Antioxidants, Mutual prodrug, Mefenamic acid, Etodolac, Sesamol, Neurodegenerative disorder https://www.ijper.org/neuroprotective-effects-of-eupatorin-against-valproic-acid-induced-autism-like-p 2026-04-23T09:41:43.143625+00:00 Neuroprotective Effects of Eupatorin against Valproic Acid-Induced Autism-Like Phenotypes in Zebrafish Embryos 2026-03-10 10.5530/ijper.20264630 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-839.pdf Purpose: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition often linked to oxidative stress and dysregulated apoptosis. Valproic Acid (VPA), a known teratogen, induces ASD-like behavioral and morphological abnormalities in zebrafish larvae. This study evaluated the neuroprotective potential of eupatorin, a naturally occurring methoxylated flavone, against VPA-induced developmental and neurobehavioral toxicity in zebrafish embryos. Materials and Methods: In this study, zebrafish em Apoptosis, Behavioral phenotype, Developmental neurotoxicity, Neuroprotection, Oxidative stress, ROS https://www.ijper.org/quality-by-design-qbd-approach-in-the-formulation-of-liposomal-gel-a-review 2026-04-23T09:41:43.143625+00:00 Quality by Design (QbD) Approach in the Formulation of Liposomal Gel: A Review 2026-03-10 10.5530/ijper.20260963 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-430.pdf Liposomal gels represent an advanced drug delivery system that combines the benefits of liposomal encapsulation with the controlled release properties of gels, offering enhanced therapeutic efficacy, stability and patient compliance. Quality by Design (QbD) is a systematic approach to pharmaceutical development, focusing on predefined objectives and emphasizing product and process understanding. This review explores the application of QbD principles in the formulation of liposomal gels, discussi Critical Quality Attributes, Liposomes, Quality by Design, Risk Assessment https://www.ijper.org/development-and-evaluation-of-chitosan-coated-plga-nanoparticles-of-canagliflozi 2026-04-23T09:41:43.143625+00:00 Development and Evaluation of Chitosan-Coated PLGA Nanoparticles of Canagliflozin for the Treatment of Hepatic Cancer 2026-03-10 10.5530/ijper.20263737 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-475.pdf Aim: The aim of the study was to develop, optimize and evaluate chitosan-coated Poly (Lactic-Co- Glycolic Acid) (PLGA) Nanoparticles (NPS) of Canagliflozin (CFZ) against the proliferation of liver cancer cells. Materials and Methods: The PLGA NPs and chitosan-coated PLGA NPs containing CFZ was optimized keeping CFZ:PLGA ratios and PVA levels as independent variables and mean Particle Size (PS), Polydispersity Index (PDI), Zeta Potential (ZP), and percent Entrapment Efficiency (EE) as the respons Canagliflozin, Chitosan, Cytotoxicity, HepG2 Cells, Liver Cancer, Nanoparticles https://www.ijper.org/development-of-an-rp-hplc-method-for-simultaneous-estimation-of-remogliflozin-me 2026-04-23T09:41:43.143625+00:00 Development of an RP-HPLC Method for Simultaneous Estimation of Remogliflozin, Metformin and Teneligliptin in Tablet Formulation 2026-03-10 10.5530/ijper.20260472 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-522.pdf Objectives: A cost-effective and reliable RP-HPLC method was developed and validated for the simultaneous estimation of Remogliflozin, Metformin and Teneligliptin in Pharmaceutical dosage form. Materials and Methods: Using an ECO-C18 (15 mm*4.6 mm*5 μ (particle size)) column with a mobile phase consisting of 0.6 M Phosphate Buffer pH 3.5: ACN (Acetonitrile) 40:60 v/v, analysis was conducted at 222 nm with a flow rate of 1.0 mL/min. Results: The validation method followed ICH guidelines, demonstr Validation, Remogliflozin, Metformin, Teneligliptin https://www.ijper.org/experimental-research-of-ions-in-wound-healing-via-film-forming-solution 2026-04-23T09:41:43.143625+00:00 Experimental Research of Ions in Wound Healing Via Film Forming Solution 2026-03-10 10.5530/ijper.20264372 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-687.pdf Objectives: This study aimed to investigate the wound healing potential of Film Forming Solution (FFS) incorporated with Silver (Ag) and Copper Oxide (CuO) Nanoparticles (NPs). Materials and Methods: Ag NPs were synthesized by chemical reduction and CuO NPs by the co-precipitation method and optimized for concentration, pH, and temperature. Characterization was performed using UV-vis spectroscopy, FT-IR, particle size analysis, zeta potential, and SEM. Antibacterial activity was assessed by dete Copper oxide, Film-forming solution, Nanoparticles, Silver, Wound healing https://www.ijper.org/optimizing-tumor-targeting-drug-delivery-of-potent-anti-cancer-drug-using-doe-gu 2026-04-23T09:41:43.143625+00:00 Optimizing Tumor-Targeting Drug Delivery of Potent Anti-Cancer Drug Using Doe-Guided Solid Lipid Nanoparticle Formulation: In vitro Cell Line Studies and Histopathological Analysis 2026-03-10 10.5530/ijper.20261953 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-776.pdf Background: Lapatinib Ditosylate emerges as a notable contender; it functions as potent selective dual tyrosine kinases ErbB-2 and EGFR inhibitor and it is a class-II drug. The present work focuses on the development of Lapatanib loaded SLNs for targeting Breast Cancer. Materials and Methods: By employing Box-Behnken design, this study evaluates the impact of three key factors on the formulation of Lapatinib-loaded SLNs: the drug-to-lipid ratio (VX1), the concentration of Labrafil (lipid phase s Lapatanib, SLNs, Box Behnken Design, Cell Line Studies, Histopathological Studies and Screening of Anticancer Efficacy https://www.ijper.org/emerging-dynamics-of-the-medical-devices-sector-in-india 2026-04-23T09:41:43.143625+00:00 Emerging Dynamics of the Medical Devices Sector in India 2026-03-10 10.5530/ijper.20260002 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-385.pdf With a current compounded annual growth rate of more than 16% and a projected market value of 12 billion US$, the medical device industry in the Indian subcontinent alone is projected to reach a market size of over 50 billion US$ by 2030. Despite being a vast market, emerging markets like India rely heavily on imports to meet most of their medical device needs. To bridge this gap, the government has envisioned developing innovative policies, indigenous facilities, practices, rules, and regulatio Medical Devices, Medical Device Regulations, Government Initiatives, Federal Policies https://www.ijper.org/antidiabetic-effect-of-selenium-laden-garlic-allium-sativum-l-in-streptozotocin 2026-04-23T09:41:43.143625+00:00 Antidiabetic Effect of Selenium-Laden Garlic (Allium sativum L.) in Streptozotocin-Induced Diabetic Rats 2026-03-10 10.5530/ijper.20266701 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-575.pdf Background: Diabetes mellitus, being a prevalent and difficult-to-treat medical condition requires special concern from researchers and medicinal practitioners. Various research showed that Selenium (Se) and Allium sativum (garlic) have antidiabetic potential, indicating Se-laden garlic (SeG) to be an effective treatment strategy. This study investigated the effects of Se-laden garlic on the streptozotocin (STZ)-induced diabetic rats. Materials and Methods: 66 Wistar rats were divided into 11 gr Allium sativum, Diabetes mellitus, Selenium, Garlic, Antidiabetic activity, Streptozotocin https://www.ijper.org/high-dose-ashwagandha-extract-a-toxicological-assessment-in-male-wistar-rats-usi 2026-04-23T09:41:43.143625+00:00 High-Dose Ashwagandha Extract: A Toxicological Assessment in Male Wistar Rats Using a Dose-Dependent Approach 2026-03-10 10.5530/ijper.20263686 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-721.pdf Background/Aim: The rising utilization of Ashwagandha (Withania somnifera), a well-known adaptogen and herbal supplement, has prompted apprehensions over its safety at elevated dosages. This study examines the potential hazardous consequences of different high dosages of Ashwagandha, seeking to elucidate its safety profile at elevated concentrations. Materials and Methods: Over 30 days, four groups of laboratory animals (male rats) were given varying high dosages of Ashwagandha root extract (200 Ashwagandha, Roots, High doses, Rats, Organ Toxicity https://www.ijper.org/nasal-delivery-of-nanoemulsion-containing-a-synergistic-combination-of-curcumin 2026-04-23T09:41:43.143625+00:00 Nasal Delivery of Nanoemulsion Containing a Synergistic Combination of Curcumin and Gefitinib for Brain Tumor Targeting 2026-03-10 10.5530/ijper.20265250 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-710.pdf Objectives: This study involves combination therapy of anticancer drugs (curcumin and gefitinib) as nanoemulsion and their application for treating human glioblastoma U373MG cell lines. Materials and Methods: Nanoemulsions containing the synergistic combination were prepared using a high-pressure homogenization technique. Nanoemulsion formulation was characterized for globule size, drug content, thermodynamic stability, zeta potential measurement and drug release. Histological studies were perfo Brain Targeting, Brain tumor, Curcumin, Gefitinib, Nanoemulsion, Nose to the brain https://www.ijper.org/herbal-medicine-in-gynecological-and-obstetric-care-a-comprehensive-review-of-cl 2026-04-23T09:41:43.143625+00:00 Herbal Medicine in Gynecological and Obstetric Care: A Comprehensive Review of Clinical Trials 2026-03-10 10.5530/ijper.20260003 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-411.pdf This review comprehensively evaluates clinical trials assessing the efficacy and safety of herbal medicines and natural products in managing gynecological and obstetric conditions. With increasing interest in complementary and alternative medicine, herbal treatments for premenstrual syndrome, dysmenorrhea, menopause, postpartum recovery, and infertility were examined. Key herbs include Vitex agnus-castus for PMS, Zingiber officinale for dysmenorrhea, Hypericum perforatum for postpartum depressio Clinical Trials, Gynecological Ailments, Herbal Medicine, Natural Products, Obstetric Health https://www.ijper.org/molecular-dynamics-characterization-of-the-nca-ii-binding-site-in-insect-gabaa-r 2026-04-23T09:41:43.143625+00:00 Molecular Dynamics Characterization of the NCA-II Binding Site in Insect GABAA Receptors and Its Application to Ligand Screening 2026-03-10 10.5530/ijper.20264008 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-507.pdf Objectives: The rapid evolution of insecticide resistance emphasizes the necessity for developing innovative approaches to discover novel insecticides that are highly selective and effective. The second generation of GABAergic Noncompetitive Antagonists (NCA-II), such as isoxazolines, constitutes a recent alternative in the design of new insecticides since they present high potency and selectivity. We aimed to contribute to the development of computational protocols that accelerate the search fo Aedes aegypti, GABAA Receptor, Molecular Dynamics Simulations, Selective Insecticides, Virtual Screening, Molecular Docking https://www.ijper.org/comparative-evaluation-of-co-crystallization-methods-for-the-solubility-enhancem 2026-04-23T09:41:43.143625+00:00 Comparative Evaluation of Co-Crystallization Methods for the Solubility Enhancement of Poorly Water-Soluble Drug of BCS Class II 2026-03-10 10.5530/ijper.20264678 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-699.pdf Background: The practice of co-crystallizing 2 or more components has gained increasing popularity to create novel materials with enhanced performance and properties compared to those composed solely of pure components. Objectives: The present study is aimed to increase solubility of Piroxicam by preparing co-crystals using methods of co-crystallization using various co-formers in different solvents. Materials and Methods: The Co-crystals of Piroxicam were prepared using solvent evaporation and Co-crystallization, Co-crystals, Improved bioavailability, Piroxicam, Slow cooling, Solvent evaporation https://www.ijper.org/development-optimization-and-characterization-of-solid-lipid-nanoparticles-of-en 2026-04-23T09:41:43.143625+00:00 Development Optimization, and Characterization of Solid Lipid Nanoparticles of Entacapone for Treatment of Parkinson Disease 2026-03-10 10.5530/ijper.20261245 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-597.pdf Introduction: Entacapone is recommended for treating Parkinson's disease. Objectives: Entacapone's high lipophilicity showed limited therapeutic efficacy in therapeutic doses. Moreover, the short half-life enabled frequent dosing, which resulted in high toxicity. Hence, the current research aimed to improve the solubility of Entacapone and thereby accelerate the absorption and efficacy via Solid Lipid Nanoparticles (SLN). Materials and Methods: FTIR assessed the drug identification and compatibi Entacapone, Solid lipid nanoparticles, Box-Behnken design, Parkinson's disease https://www.ijper.org/formulation-and-characterization-of-tizanidine-hcl-loaded-controlled-release-mes 2026-04-23T09:41:43.143625+00:00 Formulation and Characterization of Tizanidine HCl Loaded Controlled Release Mesoporous Silica Nanoparticles (MSNs) 2026-03-10 10.5530/ijper.20266522 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-497.pdf Introduction: Spasticity is a disorder in which continuous contraction of certain muscles leads to muscle stiffness. Tizanidine, a frequently prescribed skeletal muscle relaxant for spasticity treatment, exhibits a short elimination half-life and limited oral bioavailability. The aim of current study is to prepare controlled-release microparticles incorporating tizanidine-loaded Mesoporous Silica Nanoparticles (MSNs) for enhancing the bioavailability, to treat spasticity. Materials and Methods: Tizanidine, MSN, Spasticity, Controlled release, Sol-Gel Method, Box-Behnken design https://www.ijper.org/screening-optimization-and-production-of-uricase-from-a-novel-actinomycete-isola 2026-04-23T09:41:43.143625+00:00 Screening, Optimization and Production of Uricase from a Novel Actinomycete Isolate A85 2026-03-10 10.5530/ijper.20264421 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-758.pdf Background: Uricase is used to diagnose the presence of uric acid in biological fluids as well as to cure gout. Uric acid concentrations in -biological fluids are elevated by several medical disorders. Chronic renal disorders, certain organic acidemias and gout are all possible outcomes of such circumstances. Objectives: The current endeavor is primarily focused on isolating new, promising uricase-producing isolate, carrying out molecular identification and optimizing the enzyme’s production. Ma OFAT Approach, Sucrose, Uric Acid, Uricase, Variant of Streptomyces enissocaesilis https://www.ijper.org/combined-raft-formation-interpenetrating-complex-approach-to-reconstitutable-sus 2026-04-23T09:41:43.143625+00:00 Combined Raft Formation-Interpenetrating Complex Approach to Reconstitutable Sustained-Release Suspension Development 2026-03-10 10.5530/ijper.20261811 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-617.pdf Background: The foundation of this work is the use of raft formation and Interpenetrating Polymeric Network (IPN) complexation techniques to create a reconstitutable sustained-release suspension of Diltiazem Hydrochloride (DZH) for elderly patients. Materials and Methods: Xanthan gum and chitosan were used in combination to prepare IPN complexes of DZH. A central composite design was used to optimize the raft-forming in situ gelling system. The concentrations of HPMC K4M and sodium alginate were Sustained Release, IPN Complex, In situ gel, Reconstituted Suspension https://www.ijper.org/to-evaluate-the-affinity-of-chlorogenic-acid-and-ferulic-acid-towards-ppar-and-g 2026-04-23T09:41:43.143625+00:00 To Evaluate the Affinity of Chlorogenic Acid and Ferulic Acid towards PPAR-Γ and Glutathione S-Transferase Omega-1 Complex with the Docking Simulation and their Pharmacological Activities by Using their Formulation 2026-03-10 10.5530/ijper.20266738 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-748.pdf Objectives: The aim of this study was to perform molecular docking and ADMET analyses of ferulic acid and chlorogenic acid. Through molecular docking, we have observed the receptor affinity, specifically targeting the PPAR-γ receptor for anti-inflammatory activity and the Glutathione S-transferase omega-1 Complex for antioxidant activity. After confirming the affinity of compounds towards these receptor and enzyme, we performed anti-inflammatory and antioxidant activities. Materials and Methods: Ferulic Acid, Chlorogenic Acid, PPAR-Γ, Glutathione S-Transferase Omega-1 Complex, Anti-Inflammatory, Antioxidant https://www.ijper.org/fabrication-of-microneedle-patches-of-indomethacin-using-3dp-technology 2026-04-23T09:41:43.143625+00:00 Fabrication of Microneedle Patches of Indomethacin Using 3DP Technology 2026-03-10 10.5530/ijper.20264504 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-436.pdf Background: Indomethacin is a Nonsteroidal Anti-Inflammatory Drug (NSAID) that is frequently used for its pain-relieving, anti-inflammatory and fever-reducing properties. It is typically taken orally, but can also be administered rectally or intravenously in certain situations. As with all NSAIDs, indomethacin can have side effects, including gastrointestinal upset, headache, dizziness and skin rashes, the major ones being gastrointestinal bleeding and kidney problems, particularly associated wi Anti-inflammatory drug, Dermal delivery, Hydroxypropyl Methylcellulose (HPMC), Indomethacin, Microneedle patches, Polyvinyl Pyrrolidone (PVPK30) https://www.ijper.org/therapeutic-potential-of-nanosilver-encapsulated-polysaccharide-in-wound-healing 2026-04-23T09:41:43.143625+00:00 Therapeutic Potential of Nanosilver Encapsulated Polysaccharide in Wound Healing 2026-03-10 10.5530/ijper.20262151 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-853.pdf Chronic wounds create a major threat for an individual, which, if neglected, can cause severe infection in the form of sepsis. Therefore, early clinical diagnosis is very crucial to prevent further complications. Since conventional treatments are often inadequate and may lead to scar, innovative wound healing strategies are in greater demand. Recently, silver nanoparticles, due to their wide antimicrobial activity, greater surface area, and functionalization property, have garnered attention in Nanocomposite, Polysaccharide, Silver Nanoparticles, Wound Healing https://www.ijper.org/development-and-characterization-of-sustained-release-solid-dispersions-of-chlor 2026-04-23T09:41:43.143625+00:00 Development and Characterization of Sustained Release Solid Dispersions of Chlorzoxazone 2026-03-10 10.5530/ijper.20263331 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-462.pdf Objectives: The research aimed to develop Sustained Release Solid Dispersions (SRSDs) of Chlorzoxazone (COZ) to improve therapeutic efficacy and patient compliance. Materials and Methods: SRSDs were developed by the bottom-up solvent evaporation technique with various polymers, comprising Eudragit RL100, ethyl cellulose, Eudragit RS100, and cellulose acetate. Results: All eight SRSDs batches exhibited good flow properties with the Carr’s index, angle of repose, and Hausner’s ratio ranging from 1 Chlorzoxazone, Bioavailability, Sustained release solid dispersions, Solvent evaporation https://www.ijper.org/artocarpus-heterophyllus-lam-pharmacognostic-phytochemical-study-and-its-evaluat 2026-04-23T09:41:43.143625+00:00 Artocarpus heterophyllus Lam.: Pharmacognostic, Phytochemical Study and Its Evaluation for Antimitotic Potential by Modified Allium cepa Bioassay 2026-03-10 10.5530/ijper.20263421 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-541.pdf Background and Objectives: Artocarpus heterophyllus Lam. commonly known as jack tree reported to have various traditional applications, attributed by every part, for the treatment of various ailments. Although various research studies suggested the valuable importance of jack tree and still under explorations; still much is waiting to hidden out. Some of these areas include the determination of antimitotic potentials of various extracts of its leaves as a direction for head- ing towards anticanc A. heterophyllus, Allium cepa Bioassay, Antimitotic, Pharmacognostic, Phytochemical https://www.ijper.org/risk-factor-analysis-in-diabetes-and-hypertension-patients-from-odisha-india-a-c 2026-04-23T09:41:43.143625+00:00 Risk Factor Analysis in Diabetes and Hypertension Patients from Odisha, India: A Cross-Sectional Study 2026-03-10 10.5530/ijper.20262353 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-794.pdf Objectives: This study aims to investigate the incidence of poor glycemic control among elderly diabetic individuals with hypertension in urban areas of Odisha, India. This observational cross-sectional study was conducted in an urban area of Odisha involving individuals with a diabetes duration of over five years. Materials and Methods: Participants were categorized into two groups based on their glycemic control status: those with good control (HbA1C<7%) and those with poor control (HbA1C≥7%). Glycemic Control, HbA1C, Diabetes, Hypertension https://www.ijper.org/investigation-of-nanosponge-based-delivery-of-rutin-and-brucine-for-cancer-thera 2026-04-23T09:41:43.143625+00:00 Investigation of Nanosponge Based Delivery of Rutin and Brucine for Cancer Therapy 2026-03-10 10.5530/ijper.20263680 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-550.pdf Background: Both rutin and brucine can suppress tumor growth mainly through the induction of apoptosis. This study aims to evaluate the potential of nanosponge based delivery to enhance the therapeutic efficacy of rutin and brucine combination against cancer. Materials and Methods: Rutin and brucine nanosponges were prepared separately by employing the quasi-emulsion solvent diffusion method. The formulations were examined for various pharmaceutical properties as well as antioxidant and cytotoxi Antioxidant Activity, Brucine, Combination Therapy, Cytotoxicity, Nanosponges, Rutin https://www.ijper.org/in-vivo-and-in-vitro-evaluation-of-polymeric-gel-loaded-with-biologically-synthe 2026-04-23T09:41:43.143625+00:00 In vivo and in vitro Evaluation of Polymeric Gel Loaded with Biologically Synthesized Black Tea and Baliospermum solanifolium Silver Nanoparticle 2026-03-10 10.5530/ijper.20266071 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-728.pdf Aim: The overall objective of the study was to synthesise and assess a polymeric gel that contained biologically synthesised Silver Nanoparticles (AgNPs). Materials and Methods: AgNPs were produced through the reduction of Silver Nitrate (AgNO3) with Black Tea and Baliospermum solanifolium extracts separately and evaluated for different parameters. The antibacterial activity of generated nanoparticles against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli was assessed. Staph Silver nanoparticles, Black tea, Baliospermum solanifolium, Polymeric gel, Optimization, D-optimal mixture design, Wound-healing, Antibacterial activity https://www.ijper.org/emerging-trends-and-conceptual-mapping-in-network-pharmacology-research-a-biblio 2026-04-23T09:41:43.143625+00:00 Emerging Trends and Conceptual Mapping in Network Pharmacology Research: A Bibliometric Analysis (2008-2023) Using VOSviewer 2026-03-10 10.5530/ijper.20262593 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-644.pdf Background: Network Pharmacology (NP) aims to understand drug actions and their interactions with multiple targets using computational methods. Objectives: This provides a network-based approach to comprehensively investigating the effects of drugs on complex biological systems. The main objective of this bibliometric analysis in NP research (NPR) is to gain insight into the impact of research, emerging trends, collaborations, and the overall research landscape. Materials and Methods: The study Network pharmacology, Performance, Themes clustering, Bibliometrics, VOSviewer https://www.ijper.org/phytofabrication-of-magnetite-nanoparticles-from-piper-betle-l-var-mysore-and-ev 2026-04-23T09:41:43.143625+00:00 Phytofabrication of Magnetite Nanoparticles from Piper betle (L.) var. Mysore and Evaluation of Anti-Breast Cancer Potentials 2026-03-10 10.5530/ijper.20261603 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-533.pdf Background: Breast cancer is a predominant disease around the world, with early diagnosis aiding in reducing the spread and recurrence. Plant-mediated nanoparticles have shown promising results in treatment. The current study aimed to synthesize Magnetite Nanoparticles (MNPs) utilizing Piper betle var. Mysuru extract and evaluate its anti-breast cancer potentials. Materials and Methods: The green synthesis included Fe3+ and Fe2+ in a 2:1 proportion, with crude ethyl acetate extract as a reducing Magnetite nanoparticles, Phytofabrication, FTIR, XRD, DLS, MTT assay, Hemolytic Assay https://www.ijper.org/determination-of-anti-cancer-and-photo-aging-potential-of-ripened-carica-papaya 2026-04-23T09:41:43.143625+00:00 Determination of Anti-Cancer and Photo-Aging Potential of Ripened Carica papaya Fruit Extract in in vitro Cell Line Models 2026-03-10 10.5530/ijper.20261711 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-607.pdf Aim and Background: Carica papaya has been widely used in traditional medicine. However, the ripened papaya fruit remains underexplored regarding its potential as an anti-cancer and photo-aging aspect. Thus, our aim is to investigate the potential therapeutic opportunities of ripened Carica papaya fruit against colorectal cancer and photo-aging in in vitro cell models. Materials and Methods: 80% methanolic extracts were prepared using Ultrasound-Assisted Extraction (UAE) and maceration technique Carica papaya, Colorectal cancer, Photoaging, Anti-aging, Ripened papaya fruit https://www.ijper.org/formulation-and-evaluation-of-nanocrystals-of-hydrochlorothiazide 2026-04-23T09:41:43.143625+00:00 Formulation and Evaluation of Nanocrystals of Hydrochlorothiazide 2026-03-10 10.5530/ijper.20264915 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-768.pdf Aim/Background: Hydrochlorothiazide (HTZ) is a diuretic derivative and used as an antihypertensive agent with low bioavailability (around 60%) due to impaired dissolution rate. Further, excretion of HTZ is high due to rapid renal clearance (~ 320 mL/min). Objectives: Aim of the current study to improve dissolution rate of HTZs through nanocrystals technology. Materials and Methods: Nanocrystals (NC) were prepared by controlled precipitation method varying two different approaches. From the first Hydrochlorothiazide, Mannitol, Nanocrystal, Dissolution rate, Solubility, Storage stability https://www.ijper.org/design-and-development-of-chitosan-based-posaconazole-loaded-dry-powder-by-using 2026-04-23T09:41:43.143625+00:00 Design and Development of Chitosan-Based Posaconazole Loaded Dry Powder by Using BBD 2026-03-10 10.5530/ijper.20261364 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-443.pdf Aim: Quality by Design (QbD)-Optimized Spray-Dried Microparticles (prepared by using spray drying process) of Posaconazole-Loaded Chitosan Nanoparticles (POS-CSNPs) for enhanced antifungal efficacy. Materials and Methods: Box-Behnken Design (BBD) a systematic design of experiments was implemented, to screen and optimize the formulation variables for the intended qualities. Results: Outcomes showed that POS-CSNPs have particle size (259.33±6.82 nm), Poly dispersity Index (0.192±0.010), zeta poten Box-Behnken design, Dry powder Inhaler, In vitro Fungal study, Nanoparticles, Posaconazole https://www.ijper.org/design-and-evaluation-of-unidirectional-mucoadhesive-buccal-tablets-of-diclofena 2026-04-23T09:41:43.143625+00:00 Design and Evaluation of Unidirectional Mucoadhesive Buccal Tablets of Diclofenac Sodium Using Different Polymers 2026-03-10 10.5530/ijper.20263744 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-490.pdf Introduction: A mucoadhesive buccal drug delivery system is one of the novel methods to formulate the diclofenac sodium for increased bioavailability and bypass the hepatic first-pass metabolism, which would suppress the formation of peptic ulcers. The current focus of this research is to develop a mucoadhesive buccal tablet of diclofenac sodium and to evaluate its in vitro drug release profiles. Aim: The aim of this study is the design and evaluation of a unidirectional mucoadhesive buccal tabl Buccal tablet, Mucoadhesive, Adhesion time, Swelling index, Carbopol, Surface pH https://www.ijper.org/herbal-nanoparticle-embedded-film-forming-spray-a-novel-topical-delivery-system 2026-04-23T09:41:43.143625+00:00 Herbal Nanoparticle-Embedded Film-Forming Spray: A Novel Topical Delivery System for Vitiligo Management 2026-03-10 10.5530/ijper.20262653 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-656.pdf Objectives: This study evaluated a topical film-forming spray designed to improve the skin permeation of curcumin and piperine-loaded nanoparticles, aiming to enhance therapeutic efficacy and reduce dosing frequency for managing vitiligo. Materials and Methods: The HPMC E15, Polyethylene glycol 6000 and Eudragit RS100, blended in cold water and ethanol (50:50). Six criteria were utilized for evaluation: drying time, viscosity, appearance, skin effect, stickiness and water washability. The study Curcumin, Piperine, Desolvation Method, Nanoparticles, Film-forming Spray https://www.ijper.org/a-central-composite-design-optimized-diclofenac-potassium-loaded-niosomal-gel-fa 2026-04-23T09:41:43.143625+00:00 A Central Composite Design Optimized Diclofenac Potassium Loaded Niosomal Gel: Fabrication and Evaluation 2026-03-10 10.5530/ijper.20261088 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-584.pdf Aim: The goal of this study was to create niosomal carriers for delivering diclofenac potassium through the skin, aiming to understand how these niosomal vesicles can improve skin penetration and absorption. Materials and Methods: Niosomes containing diclofenac potassium were prepared using a thin film hydration method. This involved varying the ratios of non-ionic surfactants (span-60 and span-80) with Cholesterol (CHO). We optimized the niosomes using a central composite design, treating the c Central Composite Design, Diclofenac potassium, Entrapment Efficiency, Gel, In vitro Drug Release Studies, Niosomes https://www.ijper.org/formulation-and-evaluation-of-a-bromelain-loaded-nanoemulgel-for-effective-acne 2026-04-23T09:41:43.143625+00:00 Formulation and Evaluation of a Bromelain-Loaded Nanoemulgel for Effective Acne Treatment 2026-03-10 10.5530/ijper.20261446 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-815.pdf Aim: This study aimed to design, optimize, and evaluate a bromelain-infused nanoemulgel to enhance its transdermal delivery and improve therapeutic outcomes in the management of Acne vulgaris. Background: Acne vulgaris remains a prevalent dermatological condition that necessitates more effective treatment strategies. Bromelain, a proteolytic enzyme, offers significant potential for acne management but is hindered by challenges such as poor aqueous solubility, limited skin penetration, and extens Anti-microbial study, Bromelain, Nanoemulsion, Propionibacterium acnes https://www.ijper.org/design-and-development-of-simple-liquid-chromatographic-technique-for-the-rapid 2026-04-23T09:41:43.143625+00:00 Design and Development of Simple Liquid Chromatographic Technique for the Rapid Determination of Ruxolitinib (RUXO) in Bulk Drugs along with Characterization of Forced Degradation Studies 2026-03-10 10.5530/ijper.20262561 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2s-739.pdf Objectives: The motive behind this work is to develop a simple, rapid, accurate, and precise High-Performance Liquid Chromatography (HPLC) method for determining Ruxolitinib (RUXO) in bulk drugs and to study drug degradation behavior under various stress conditions as per International Council for Harmonization (ICH) guidelines. Materials and Methods: In this method, a Phenomenex ODS C-18 (250×4.6 mm, 5 µm) column was used by taking a mobile phase, which is methanol to acetonitrile, in the ratio Ruxolitinib, HPLC, Method Development, Validation, Force Degradation Studies, ICH Guidelines https://www.ijper.org/exploring-a-novel-approach-in-vitro-cytotoxicity-study-of-capecitabine-loaded-re 2026-04-25T09:29:05.811126+00:00 Exploring a Novel Approach: In vitro Cytotoxicity Study of Capecitabine Loaded Resealed Erythrocytes 2026-01-06 10.5530/ijper.20266766 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-575.pdf Background: Conventional chemotherapy with Capecitabine is often associated with systemic toxicity, poor tumour selectivity, and suboptimal drug concentrations at tumour sites, limiting its therapeutic efficacy. Advanced drug delivery strategies are needed to enhance drug bioavailability while minimizing adverse effects. Objectives: This study investigates resealed erythrocytes as a novel drug delivery system for Capecitabine, aiming to improve targeted drug release, therapeutic efficacy, and bi Cancer, Cytotoxicity, Capecitabine, Resealed erythrocytes, MTT assay, Apoptosis. https://www.ijper.org/design-expert-optimization-of-transdermal-patches-for-effective-prolonged-releas 2026-04-25T09:28:01.519323+00:00 Design Expert Optimization of Transdermal Patches for Effective Prolonged Release of Alzheimer's Medications 2026-01-06 10.5530/ijper.20260354 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-521.pdf Objectives: This study aimed to develop and characterize transdermal patches for Donepezil (DPZ) and Memantine (MMT) using a Box-Behnken Design (BBD), evaluating drug permeation at 8 hr, 16 hr, and 24 hr, with optimization through Design Expert software. Materials and Methods: The patches were formulated with HPMC K15, modified chitosan, and PVP K30. The physicochemical properties and drug infusion were tested and characterized. Results: The transdermal patches developed in this study were found Box Behnken Design, Drug permeation, Extended release, Flexibility. https://www.ijper.org/innovative-exploration-of-the-connotation-and-education-and-training-practice-pa 2026-04-25T09:27:37.910874+00:00 Innovative Exploration of the Connotation and Education and Training Practice Path of Outstanding Pharmaceutical Engineers 2026-01-06 10.5530/ijper.20266248 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-511.pdf Objectives: China is on the way to improving the education and training of outstanding pharmaceutical engineers. Still, the training of pharmaceutical engineers cannot meet the needs of innovative drug development and transformation research. So, it is worth sorting out the existing problems to improve the professional identity, enhancing professional confidence and the quality of the training. Materials and Methods: First, using questionnaires and interviews to understand the current situation Outstanding pharmaceutical engineer, Connotation, Practical path, China, Occupational competency. https://www.ijper.org/recent-advances-in-pharmacotherapeutic-approaches-for-alopecia-areata-a-systemat 2026-04-25T09:34:09.986583+00:00 Recent Advances in Pharmacotherapeutic Approaches for Alopecia areata: A Systematic Review of Clinical Trials from the Last Decade 2026-01-06 10.5530/ijper.20262806 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-809.pdf Background: Alopecia areata (AA) is an autoimmune disorder with diverse clinical presentations and limited universally effective therapeutic options. Over the past decade, numerous treatment strategies have emerged, including Janus Kinase (JAK) inhibitors, corticosteroids, laser therapies, PRP (Platelet-Rich Plasma), and novel alternative agents. Objectives: To systematically review and synthesize clinical trial evidence from the last ten years evaluating treatment modalities for AA with a focus Alopecia areata, Janus Kinase Inhibitors, Systematic Review, Hair Regrowth, Treatment Modalities. https://www.ijper.org/herb-drug-interaction-evaluation-on-concomitant-administration-of-ime-9-and-glic 2026-04-25T09:32:07.081727+00:00 Herb-Drug Interaction Evaluation on Concomitant Administration of IME-9 and Gliclazide in Preclinical Diabetic Rats 2026-01-06 10.5530/ijper.20267022 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-683.pdf Background: Diabetes mellitus is the third most prevalent cause of mortality and morbidity globally. Several complementary or alternative therapies currently used to treat diabetes mellitus. IME-9 is a polyherbal preparation used to treat diabetes and contains numerous phytoconstituents that can alter the cytochrome enzymes, mainly CYP2C8, 2B6, 2D6, 1A2, 2C9, 2C19, and 3A4. Gliclazide is a commonly prescribed antidiabetic drug metabolized primarily by the CYP2C9 and CYP2C19 enzymes. Thereby, it Diabetes Mellitus, Gliclazide, HDI, IME-9, Pharmacodynamic, Pharmacokinetic. https://www.ijper.org/effect-of-ciprofloxacin-on-some-oxidative-stress-parameters-and-tnf-il-6-and-bdn 2026-04-25T09:28:55.621967+00:00 Effect of Ciprofloxacin on Some Oxidative Stress Parameters and TNF-α, IL-6 and BDNF in Diabetic Rats with Urinary Tract İnfection Induced by Escherichia coli 2026-01-06 10.5530/ijper.20266403 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-566.pdf Background: Diabetes Mellitus (DM) and Urinary Tract Infections (UTIs) are common conditions that, especially when occurring together, lead to significant morbidity. This study aimed to investigate the effects of Ciprofloxacin (CIP) treatment on oxidative stress, antioxidant defense systems, and inflammatory markers in a rat model of experimental DM and E. coli-induced UTI. Materials and Methods: The study was conducted on rats with experimental DM and E. coli-induced UTI. CIP treatment was admi BDNF, Ciprofloxacin, Diabetüs Mellitüs, Oxidative Stress. https://www.ijper.org/formulation-development-and-evaluation-of-fast-dissolving-tablets-of-bisoprolol 2026-04-25T09:28:36.633822+00:00 Formulation Development and Evaluation of Fast Dissolving Tablets of Bisoprolol Fumarate using Response Surface Technique 2026-01-06 10.5530/ijper.20266837 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-550.pdf Objectives: The purpose of the current study was to develop and evaluate Fast Dissolving Tablets (FDT) for the successful management of hypertension and heart failure utilizing the response surface technique. Bisoprolol Fumarate is a highly effective cardio selective beta-blocker. Materials and Methods: 12 Fast Dissolving Formulations were developed for Bisoprolol fumarate using various various concentrations of super disintegrants. Among all, The Formulation F6 showed promising results were con Bisoprolol Fumarate, Super disintegrants, Magnesium stearate, Lactose, Non-Fickian diffusion, Super case transport. https://www.ijper.org/overcoming-implementation-challenges-a-comprehensive-review-of-asean-medical-dev 2026-04-25T09:26:17.813829+00:00 Overcoming Implementation Challenges: A Comprehensive Review of ASEAN Medical Device Directive (AMDD) Regulatory Harmonization 2026-01-06 10.5530/ijper.20260969 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-467.pdf The challenges of AMDD implantation across Southeast Asia are uniformly bringing medical device regulations better in line to improve the safety of patients while reducing regulatory hurdles and boosting regional trade. By using a mixed-methods approach-literature review, stakeholder interviews and the study reveals important barriers: inconsistencies in regulations, technical challenges, resource limitations, economic effects, post-market surveillance issues and language differences. The paper ASEAN Medical Device Directive (AMDD), Implementation challenges, Patient Safety, Regulatory harmonization, Southeast Asia. https://www.ijper.org/multidisciplinary-approach-for-designing-of-drug-delivery-system-leveraging-arti 2026-04-25T09:26:55.868294+00:00 Multidisciplinary Approach for Designing of Drug Delivery System: Leveraging Artificial Intelligence and Experimental Design for Enhanced Helicobacter pylori Formulation Optimization 2026-01-06 10.5530/ijper.20261624 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-485.pdf The management of Helicobacter pylori (H. pylori) remains a complicated challenge worldwide. There is need for more effective optimised formulations with better therapeutic efficiency and less drug resistance. Rapid advancements have been achieved regarding the development of pharmaceutical formulations for the treatment of H. pylori, which demands new and improved approaches towards product optimization. This review gives an account of a combined approach of employing Design of Experiments and Helicobacter pylori treatment, Artificial intelligence, Design of experiments, 3D printing. https://www.ijper.org/polydatin-induces-apoptosis-in-thyroid-cancer-tpc-i-cells-by-regulating-apoptoti 2026-04-25T09:33:09.954515+00:00 Polydatin Induces Apoptosis in Thyroid Cancer TPC-I Cells by Regulating Apoptotic Proteins and Downregulating JAK/ STAT Pathway 2026-01-06 10.5530/ijper.20262136 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-749.pdf Background: Thyroid cancer is relatively uncommon but its incidence has been steadily increasing over the past years. The etiology of thyroid cancer is multifaceted, with both genetic and environmental causes playing major roles. Objectives: This work was devoted to explore the anticancer properties of the polydatin against papillary thyroid carcinoma TPC-I cells. Materials and Methods: The cytotoxicity of polydatin (at doses of 5-160 μM/mL) against thyroid cancer TPC-I cells were tested using t Cyclin D1, JAK/STAT pathway, Polydatin, Apoptosis, TPC-I cells. https://www.ijper.org/green-synthesized-zinc-oxide-nanoparticles-using-musa-acuminata-corm-extract-and 2026-04-25T09:31:27.286388+00:00 Green Synthesized Zinc Oxide Nanoparticles Using Musa acuminata Corm Extract and Its Anti-Cancer Activity 2026-01-06 10.5530/ijper.20262292 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-642.pdf Background Information: Osteosarcoma is the most common type of bone cancer, typically affecting children and young adults. It primarily develops in the long bones of the arms and legs. The banana (Musa spp) is widely popular in tropical regions around the world. One of its species, the Cavendish banana (Musa acuminata), is a wild plant that thrives in tropical and subtropical climates. In recent years, the health benefits of M. acuminata have gained considerable attention. Different parts of th Musa acuminata, Reactive oxygen species, Wound healing, Osteosarcoma, Zinc oxide nanoparticle. https://www.ijper.org/differential-evaluation-of-multi-index-components-in-different-parts-of-ophiopog 2026-04-25T09:29:37.247113+00:00 Differential Evaluation of Multi-Index Components in Different Parts of Ophiopogon japonicus 2026-01-06 10.5530/ijper.20260713 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-604.pdf Objectives: To establish a method for determination of 11 components content to evaluate their quality and compare the difference between tuberous root and fibrous root of Ophiopogon japonicus by multivariate statistical analysis. Materials and Methods: The contents of total saponins, total flavonoids and total polysaccharides were determined by ultraviolet-visible spectrophotometry. The mineral elements were determined by atomic absorption spectrophotometry. Cluster analysis, partial least squa Different parts, Differential evaluation, Ophiopogon japonicus. https://www.ijper.org/protective-mechanism-of-nlrp3-inflammatory-bodies-mediated-by-dexmedetomidine-on 2026-04-25T09:29:28.752288+00:00 Protective Mechanism of NLRP3 Inflammatory Bodies Mediated by Dexmedetomidine on Renal Injury in Rats with Hemorrhagic Shock 2026-01-06 10.5530/ijper.20260639 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-598.pdf Objectives: to investigate the protective mechanism of NLRP3 inflammatory bodies mediated by Dexmedetomidine (DEX) on renal injury in rats with hemorrhagic shock. Materials and Methods: 18 healthy SD rats were divided into control (group A), model (group B) and right metomidine (group C) group. Group B and C were used to establish the model of hemorrhagic shock by improved Wiggers method. After successful modeling, the group B was injected intravenously with normal saline 5 μg kg-1 h-1. The pati Dexmedetomidine, Nlrp3 Inflammatory Bodies, Hemorrhagic Shock, Renal Injury, Protective Mechanism. https://www.ijper.org/unraveling-the-therapeutic-potential-of-apigenin-targeting-cdk6-in-cancer-treatm 2026-04-25T09:29:18.522244+00:00 Unraveling the Therapeutic Potential of Apigenin: Targeting CDK6 in Cancer Treatment 2026-01-06 10.5530/ijper.20260852 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-582.pdf Background: The pursuit of effective cancer therapies hinges upon the identification and characterization of molecular targets amenable to precise modulation. Herein, we present a comprehensive investigation into the potential of Apigenin as a therapeutic agent targeting Cyclin-Dependent Kinase 6 (CDK6), a critical regulator of cell cycle progression implicated in tumorigenesis. Materials and Methods: Initially, we employed protein structure homology modelling to elucidate the high-resolution st Apigenin, Cancer, Cyclin-Dependent Kinase 6 (CDK6), HCT-15 cancer cells, HeLa-229 cancer cells, PC-3 cancer cells, targeted therapy. https://www.ijper.org/novel-edc-crosslinked-hydroxypropyl-banana-musa-paradisiaca-starch-as-a-superdis 2026-04-25T09:35:55.537083+00:00 Novel EDC-Crosslinked Hydroxypropyl banana (Musa paradisiaca) starch as a Superdisintegrant for Enhanced Oral Delivery of Pioglitazone Hydrochloride in Orodispersible Tablets 2026-01-06 10.5530/ijper.20261872 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-903.pdf Background: Orally Disintegrating Tablets (ODTs) are gaining attention for improving patient compliance, especially in pediatric, geriatric, and dysphagic populations. Objective: This study aimed to develop and evaluate pioglitazone hydrochloride ODTs using EDC-Crosslinked Hydroxypropyl Banana starch (EDC-BS) as a novel, natural superdisintegrant. The objective was to assess the efficiency of EDC-BS in enhancing tablet disintegration and drug release compared to standard formulations containing Orodispersible tablets, EDC-crosslinked banana starch, Superdisintegrant, Pioglitazone hydrochloride, Drug release, Pharmaceutical formulation. https://www.ijper.org/mitigating-cisplatin-induced-nephrotoxicity-with-morin-a-flavonoids-role-in-nrf2 2026-04-25T09:28:46.175217+00:00 Mitigating Cisplatin-Induced Nephrotoxicity with Morin: A Flavonoid's Role in Nrf2/HO-1 Pathway Activation in HEK 293 Cells 2026-01-06 10.5530/ijper.20261971 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-558.pdf Objectives: Cisplatin is a widely used chemotherapeutic agent used in various cancers, but its clinical use is limited due to its dose-dependent toxicity, especially nephrotoxicity. Flavonoids are a class of natural compounds that often show kidney-protecting function. The current study aimed to investigate the probable mechanism of morin, a flavonoid in cisplatin-induced nephrotoxicity and the involvement of Nrf2 pathways in managing the stress induced in HEK 293 cells. Materials and Methods: C Antioxidant, Cisplatin, HEK 293 cells, Morin, Nephrotoxicity, Nrf2 pathway. https://www.ijper.org/conessine-as-a-novel-anti-quorum-sensing-agent-against-streptococcus-mutans-an-i 2026-04-25T09:31:55.756312+00:00 Conessine as A Novel Anti-Quorum Sensing Agent against Streptococcus mutans: An in vitro Analysis of Biofilm Inhibition 2026-01-06 10.5530/ijper.20262947 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-673.pdf Background: Dental caries concerns not solely the painful decay and eventual loss of the tooth but also significantly impacts an individual's physical, mental, and social health. The quest for potential Quorum Sensing (QS) inhibitors to hinder virulence, especially to mitigate the emergence of antibiotic resistance among caries pathogens, is increasing in this era of finding treatments from natural resources. Objectives: With the goal of finding a novel QS inhibitor, a plant alkaloid, conessine, Phytochemicals, Anti-Biofilm, Anti-caries, Virulence, Tooth Decay. https://www.ijper.org/bioequivalence-and-bioavailability-studies-regulatory-assessment-and-study-desig 2026-04-25T09:26:08.436327+00:00 Bioequivalence and Bioavailability Studies: Regulatory Assessment and Study Design Considerations and Pharmacokinetic Parameters 2026-01-06 10.5530/ijper.20260065 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-460.pdf Bioequivalence and bioavailability studies are vital components of the pharmaceutical industry, ensuring the safety, efficacy and interchangeability of generic drugs compared to their reference products. This comprehensive research paper dives deeper into the concepts of the principles of bioequivalence and bioavailability. The application of the Biopharmaceutics Classification System (BCS) in evaluating bioequivalence, different study designs used in these assessments. A thorough review of bioe Bioequivalence, Study Design, EMA, USFDA. https://www.ijper.org/schaftoside-attenuates-myocardial-ischemiareperfusion-injury-in-streptozotocin-i 2026-04-25T09:31:16.881975+00:00 Schaftoside Attenuates Myocardial Ischemia/Reperfusion Injury in Streptozotocin-Induced Diabetic Rats 2026-01-06 10.5530/ijper.20261984 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-630.pdf Background: Diabetes mellitus, a chronic metabolic disorder defined by persistent hyperglycemia, is a foremost global health issue. A significant complication of diabetes is the heightened risk of cardiovascular diseases. Objectives: The current work was planned to disclose the cardioprotective properties of the schaftoside against Myocardial Ischemic Reperfusion Injury (MIRI) in diabetic rats. Materials and Methods: The rats were treated with 60 mg/kg Streptozotocin (STZ) to induce diabetes and Myocardial injury, Diabetes Mellitus, Schaftoside, Glycated Haemoglobin, Cardiac Troponin-I. https://www.ijper.org/formulation-and-evaluation-of-p-naphthoquinone-casein-nanodispersions-and-their 2026-04-25T09:32:41.03232+00:00 Formulation and Evaluation of P-Naphthoquinone Casein Nanodispersions and their Antibacterial and Anticancer Activities 2026-01-06 10.5530/ijper.20261335 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-717.pdf Aim/Background: This study focuses on the preparation, characterization, and evaluation of nanodispersion formulations of casein and PNQ for their antibacterial and anticancer activities. Casein micelles were used to stabilize PNQ precipitates, aiming to enhance bioavailability and therapeutic efficacy. Materials and Methods: Nanodispersion formulations were prepared and characterized using a Zeta sizer to determine particle size and stability. The average particle size ranged between 230 nm and Antibacterial, Anticancer, Casein Nanodispersion, p-Naphthoquinone. https://www.ijper.org/antimicrobial-activity-of-acacia-tortilis-talha-of-tindouf-against-bacteria-and 2026-04-25T09:34:40.906621+00:00 Antimicrobial Activity of Acacia tortilis (Talha of Tindouf) against Bacteria and Fungi Isolated from Various Water Sources in the Elbayadh Region (Algeria) 2026-01-06 10.5530/ijper.20265564 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-845.pdf Background: In El Bayadh province, water is an essential resource for survival, prompting residents to settle in areas next to water springs that provide drinking water and support livestock. Water contamination poses a significant threat to humanity, especially in the El Bayadh region. Biological contamination is a substantial risk to water sources. Our research focused on the utilization of medicinal plants to alleviate pollution. Phytochemicals have numerous medical applications and have anti Water, Acacia gum, Antibiological effect, Physico-chemical and Microbiological analysis. https://www.ijper.org/formulation-development-and-evaluation-of-fast-dissolving-sublingual-film-of-api 2026-04-25T09:28:23.672524+00:00 Formulation Development and Evaluation of Fast Dissolving Sublingual Film of Apixaban: Design of Experiment-Based Approach 2026-01-06 10.5530/ijper.20265848 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-539.pdf Objectives: The benefits of the active ingredients are circumvented due to poor bioavailability or presystemic metabolism. Apixaban is an oral anticoagulant possessing high lipophilicity and bioavailability of less than 50%. This drawback can easily be overcome with the help of a sublingual route of administration in the form of the oral thin film. The present research was carried out to improve Apixaban solubility, bioavailability, and therapeutic efficacy. Materials and Methods: The compatibil Oral thin film, Apixaban, HPMC E15, Box-Behnken Design, Deep vein thrombosis, Pulmonary embolism. https://www.ijper.org/untitled-article 2026-04-25T09:34:00.217306+00:00 Untitled Article 2026-01-06 10.5530/ijper.20262622 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-798.pdf Background: Osteoporosis is a common skeletal condition marked by decreased bone density and impaired bone microarchitecture, which substantially increases the fracture risks. This systemic condition results from a disproportion in bone homeostasis, when bone resorption exceeds bone formation. Objectives: This work focuses to study the anti-osteoporotic efficacy of bilobetin against Overiectomy (OVX)-induced osteoporosis in rat model. Materials and Methods: The OVX surgery was done on the experi Bone Remodeling, Calcium Homeostasis, Bilobetin, Overiectomy, RANKL/OPG Pathway. https://www.ijper.org/sophoricoside-alleviates-oxidative-stress-and-inflammation-in-streptozotocin-ind 2026-04-25T09:32:50.801951+00:00 Sophoricoside Alleviates Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetes Mellitus in Rats 2026-01-06 10.5530/ijper.20262129 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-729.pdf Background: Diabetes mellitus, a chronic metabolic condition defined by chronic hyperglycemia, presents a major global health challenge with increasing prevalence and profound implications for individual’s well-being and healthcare systems. Objectives: This work was aimed at studying the anti-diabetic properties of sophoricoside against Streptozotocin (STZ)-induced diabetes in rats. Materials and Methods: In this experimental model, diabetic condition was initiated in rats by injecting a single Hyperglycemia, Insulin, Sophoricoside, Pancreas, Streptozotocin, Oxidative stress. https://www.ijper.org/combinatory-effects-of-resveratrol-and-curcumin-in-a-murine-model-of-acuteon-chr 2026-04-25T09:33:37.632631+00:00 Combinatory Effects of Resveratrol and Curcumin in a Murine Model of Acuteon Chronic Liver Failure 2026-01-06 10.5530/ijper.20262571 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-780.pdf Objectives: Acute-on-Chronic Liver Failure (ACLF) in cirrhosis patients involves rapid health decline, organ failure, and high mortality. This study aimed to assess the therapeutic effects of curcumin and resveratrol in treating ACLF in mice. Materials and Methods: ACLF was induced in 6-8-week-old C57BL6 mice (20-24 g) by chronic liver damage and carbon tetrachloride (CCl4) injections for 10 weeks, followed by acute injury via Acetaminophen (APAP) and Lipopolysaccharide (LPS). Mice were divided Resveratrol, Curcumin, Acute-on-chronic Liver Failure, Combination Therapy. https://www.ijper.org/unveiling-the-bioactive-potential-of-mannich-bases-synthesis-characterization-an 2026-04-25T09:35:33.569362+00:00 Unveiling the Bioactive Potential of Mannich Bases: Synthesis, Characterization, and Biological Perspectives 2026-01-06 10.5530/ijper.20261518 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-884.pdf Background: This study evaluates the antimicrobial and molecular docking profiles of 12 novel Mannich bases (MB1-MB12) to find potential candidates effective against Escherichia coli, Staphylococcus aureus, and Candida albicans. This study discusses the urgent need for new therapeutic agents with enhanced efficacy to combat the fast-growing problem of antimicrobial resistance. The compounds were synthesized using the Mannich reaction, which includes the reaction of aromatic amines, formaldehyde, Mannich bases, Molecular docking studies, ADME prediction, Antitubercular activity, Anti-microbial activity. https://www.ijper.org/cardioprotective-effects-of-piperlongumine-against-doxorubicin-induced-myocardia 2026-04-25T09:33:19.101175+00:00 Cardioprotective Effects of Piperlongumine against Doxorubicin-Induced Myocardial Infarction via Down-Regulating Cardiac Biomarkers in Rats 2026-01-06 10.5530/ijper.20262259 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-758.pdf Background: Doxorubicin, an extensively utilized antineoplastic agent, has been a significant contributor to the remarkable advancements in cancer treatment over the past several decades. However, the clinical usefulness of this powerful drug is often restricted by its well-documented cardiotoxic effects. Objectives: The present research work was focused at unveiling the therapeutic roles of piperlongumine against doxorubicin-induced cardiotoxicity. Materials and Methods: The experimental rats w Cardiotoxicity, Piperlongumine, Cardiomyocytes, Hemodynamic markers, Heart weight. https://www.ijper.org/formulation-and-evaluation-of-cilnidipine-loaded-nanoparticles-for-enhanced-solu 2026-04-25T09:28:12.368143+00:00 Formulation and Evaluation of Cilnidipine Loaded Nanoparticles for Enhanced Solubility 2026-01-06 10.5530/ijper.20263140 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-532.pdf Introduction: Poorly water-soluble drugs present challenges in development of formulation using conventional methods and are resulting in poor drug performance. Formulating these molecules into nanoparticles based drug delivery, enhances the drug solubility and efficacy. Objectives: The objective of this study is to prepare and evaluate cilnidipine loaded nanoparticles to improve the solubility. Materials and Methods: Nanoparticles loaded with cilnidipine was prepared by solvent evaporation meth Nanoparticulate Drug Delivery, Nanoparticles, Cilnidipine, Solvent Evaporation Method, Dissolution Study. https://www.ijper.org/berbamine-ameliorates-lps-induced-inflammation-in-raw2647-cells-and-ovalbumin-in 2026-04-25T09:31:36.576641+00:00 Berbamine Ameliorates LPS-Induced Inflammation in RAW264.7 Cells and Ovalbumin-Induced Allergic Asthma in Mice 2026-01-06 10.5530/ijper.20262086 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-652.pdf Background: Asthma is a common and long-lasting respiratory disorder affecting more than 300 million individuals worldwide. Berbamine is a natural and highly active pharmacological compound extracted from the plant Berberis amurensis. Objectives: In our study, we evaluated the potency of berbamine against asthma, a non-communicable chronic lung disease that affects approximately 300 million individuals and is a foremost cause of mortality associated with long-lasting respiratory ailment. Materia Allergic asthma, Phytoalkaloids, Berbamine, LPS stimulation in vitro model, Ovalbumin sensitization in vivo model, Type 2 inflammation. https://www.ijper.org/topiramate-versus-acetazolamide-for-idiopathic-intracranial-hypertension-a-real 2026-04-25T09:29:47.074825+00:00 Topiramate Versus Acetazolamide for Idiopathic Intracranial Hypertension. A Real-World Data-Based Multicenter Retrospective Study 2026-01-06 10.5530/ijper.20261194 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-614.pdf Introduction: Idiopathic Intracranial Hypertension (IIH) is a condition marked by elevated intracranial pressure without mass lesions or hydrocephalus, primarily affecting young obese women. Acetazolamide has been the standard treatment, but its side effects often limit use. Topiramate, an anticonvulsant, has gained attention for its dual role as a carbonic anhydrase inhibitor and weight loss promoter. This study compares the efficacy and safety of topiramate versus acetazolamide in IIH manageme Acetazolamide, Idiopathic Intracranial Hypetension, Papilledema, Pseudotumor Cerebri, Topiramate. https://www.ijper.org/advancing-pharmaceutical-reliability-innovations-in-stability-indicating-assay-m 2026-04-25T09:26:25.755853+00:00 Advancing Pharmaceutical Reliability: Innovations in Stability-Indicating Assay Methods 2026-01-06 10.5530/ijper.20261191 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-474.pdf The design and development of Stability-Indicating Assay Methods (SIAMs) are critical in the pharmaceutical industry to ensure the safety and efficacy of drug products throughout their shelf-life. These methods are specifically tailored to detect and quantify the Active Pharmaceutical Ingredient (API) and any potential degradation products under various stress conditions. Advanced analytical techniques such as HPLC, GC, and MS play pivotal roles in these developments. Ongoing advancements in tec Analytical techniques, GC, HPLC, MS, Pharmaceutical stability, Regulatory Compliance, SIAMs, Stability Indicator Assay methods. https://www.ijper.org/hederagenin-shows-protective-effects-against-sodium-selenite-induced-oxidative-s 2026-04-25T09:31:45.837376+00:00 Hederagenin Shows Protective Effects Against Sodium Selenite-Induced Oxidative Stress and Cataractogenesis in Rats via Activation of Nrf2/HO-1 Pathway 2026-01-06 10.5530/ijper.20262754 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-663.pdf Background: Cataracts, a pervasive ocular condition, are defined by the progressive opacification of the crystalline lens, leading to a gradual decline in visual acuity and overall quality of life. This lens clouding obstructs the passage of light to the retina, resulting in blurred or distorted vision. Objectives: The current study was performed to investigate the protective mechanisms of hederagenin against sodium selenite-induced cataract formation in rat pups. Materials and Methods: Experime Nrf-2/HO-1 pathway, Cataractogenesis, Cyclooxygenase-2, Hederagenin, Lens opacification. https://www.ijper.org/wound-healing-potential-of-curcumin-and-colostrum-loaded-liposomes-in-diabetic-f 2026-04-25T09:34:20.541477+00:00 Wound Healing Potential of Curcumin and Colostrum- Loaded Liposomes in Diabetic Foot Ulcers 2026-01-06 10.5530/ijper.20263371 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-830.pdf Background: Diabetic Foot Ulcers (DFUs), a serious diabetes consequence, are caused primarily by hyperglycemia, oxidative stress, and chronic inflammation. This study aims to evaluate the therapeutic potential of liposome-based formulations containing curcumin, colostrum, or both for oral and topical delivery in DFU management. Materials and Methods: The thin film hydration approach was used to develop the liposomes, and their pharmaceutical characteristics were assessed. These liposomes were mo Colostrum, Curcuma, Liposomes, Oral, Topical, Hydrogel, Inflammatory Marker, Oxidative Injury, Foot Ulcers. https://www.ijper.org/animal-models-and-pathogenesis-on-neurodegenerative-disorders-huntingtons-diseas 2026-04-25T09:27:25.316226+00:00 Animal Models and Pathogenesis on Neurodegenerative Disorders (Huntington’s Disease): An Updated Review 2026-01-06 10.5530/ijper.20262132 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-494.pdf Background and Objectives: Huntington’s Disease (HD) is a rare neurodegenerative disorder marked by abnormal body movements, behavioral and psychiatric issues, and dementia. This inherited genetic disorder leads to cognitive dysfunction and abnormal movements known as chorea. The condition was first accurately described by George Huntington, an Ohio physician, in 1872. HD is a dominantly inherited illness that causes progressive neurodegeneration in the striatum and other brain regions, particul Huntington’s disease, Neurodegenerative disorder, Cognitive disorder, Motor disorder. https://www.ijper.org/validated-hptlc-method-for-accurate-measurement-of-quercetin-in-ficus-benghalens 2026-04-25T09:35:11.806596+00:00 Validated HPTLC Method for Accurate Measurement of Quercetin in Ficus benghalensis Linn. Bark Extract 2026-01-06 10.5530/ijper.20261891 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-869.pdf Background: Quercetin is a key bioactive compound found in many plants and trees, popularly known for its ability to act as a potent antioxidant, reduce inflammation, decreases the risk of cancer, heart disease, and neurological disorders, and even help with allergies and infections. The bark of Ficus benghalensis Linn. Commonly known as banyan tree is believed to be rich in quercetin, making its accurate measurement essential for understanding its health benefits. Purpose: This study focuses on High-Performance Thin Layer Chromatography (HPTLC), Quercetin, Flavonoids, Ficus benghalensis Linn., Accuracy, LOD, LOQ. https://www.ijper.org/dose-dependent-effects-of-herbal-extract-on-reproductive-health-implications-for 2026-04-25T09:32:17.81094+00:00 Dose-Dependent Effects of Herbal Extract on Reproductive Health: Implications for Ovarian Structure, Organ Weight and Hormonal Balance in Female Rats 2026-01-06 10.5530/ijper.20260951 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-699.pdf Aim: Investigate the impact of varying dosages (100 mg and 250 mg/kg) of a specific herbal extract on reproductive parameters in female albino rats. Background: Herbal extracts are extensively utilized in traditional medicine for their possible therapeutic advantages, including the promotion of reproductive health. The effects of different dosages on reproductive function are little comprehended. Materials and Methods: This research examines the dose-dependent impacts of a particular herbal extr Dose-dependent effects, Female rats, Herbal extract, Hormone levels, Ovarian histopathology, Reproductive health. https://www.ijper.org/cognitive-enhancing-and-the-neuroprotective-propensity-of-heartwood-caesalpinia 2026-04-25T09:32:31.86092+00:00 Cognitive-Enhancing and the Neuroprotective Propensity of Heartwood Caesalpinia sappan against D-Galactose- Induced Cognitive Impairments on Wistar Rats 2026-01-06 10.5530/ijper.20260515 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-707.pdf Background: We suggest evaluating heartwood Caesalpinia sappan's capacity to both protect neurons and improve cognition in Wistar rats by protecting them from the cognitive deficits caused by D-galactose. Objectives: The purpose of investigation was to identify Caesalpinia sappan's neuroprotective and cognitive-enhancing effects against D-galactose-induced cognitive impairments on Wistar rats. Materials and Methods: Cognitive impairment in rats was induced by injecting 2 mg/kg of d-galactose. Wi Alzheimer's disease, Behavioural parameters, Caesalpinia sappan, Histopathology analysis, Immunoblotting studies, In vivo studies, Neurotransmitters. https://www.ijper.org/formulation-characterization-in-vitro-and-mtt-cytotoxicity-evaluation-of-pioglit 2026-04-25T09:32:59.993815+00:00 Formulation, Characterization, in vitro and MTT Cytotoxicity Evaluation of Pioglitazone HCl Films for Topical Administration 2026-01-06 10.5530/ijper.20262124 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-739.pdf Aim: The main focus of the study was to create and analyze novel formulation to explore the potential of Pioglitazone HCl with Guar Gum, Chitosan and Sodium alginate for topical delivery and evaluate them. Materials and Methods: Pioglitazone HCl loaded films were formulated by solvent evaporation technique and were subsequently incorporated within the Guar gum and Chitosan. Results: For the investigation, various physicochemical parameters along with in vitro drug release studies, and accelerate In vitro Studies, MTT Assay Higuchi kinetics and Korsmeyer-Peppas Analysis, IC50 value. https://www.ijper.org/coordination-scaffolds-of-schiff-base-derived-from-imatinib-amine-synthesis-spec 2026-04-25T09:35:22.608831+00:00 Coordination Scaffolds of Schiff Base Derived from Imatinib Amine: Synthesis, Spectroscopic and in vitro Biological Screening 2026-01-06 10.5530/ijper.20260929 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-876.pdf Aim: Imatinib amine based Schiff base heterochelates: Synthesis, Spectroscopic and in vitro biological screening. Materials and Methods: We acquired 2-Hydroxy-5-bromo benzaldehyde and 2-Hydroxy-5-nitro benzaldehyde from Sigma Ltd. (India). Purchased from Almon Industries in Ahmedabad, Gujarat, India, imatinib amine was utilised unpurified. Results: Elements C, H and N were elementally analysed using a Perkin-Elmer model 2400 elemental analyzer; 1H NMR spectra were obtained with an Advance 400 Br Antimicrobial studies, Imatinib amine, Schiff base, Spectroscopic studies, Transition metal-based coordination compounds. https://www.ijper.org/formulation-characterization-and-evaluation-of-naringin-loaded-phytosomal-gel-an 2026-04-25T09:33:28.432145+00:00 Formulation, Characterization, and Evaluation of Naringin-Loaded Phytosomal Gel and it’s in vivo Anti-Inflammatory Activity by Carrageenan Animal Model 2026-01-06 10.5530/ijper.20263075 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-768.pdf Objective: The present study aimed to formulate, optimize, and evaluate a Naringin-loaded phytosomal gel using a 3² factorial design and to assess its anti-inflammatory activity. Materials and Methods: Phytosomes were prepared via the thin-film hydration method using soya lecithin and cholesterol and were characterized for vesicle size, Polydispersity Index (PDI), and entrapment efficiency. Results: Vesicle sizes ranged from 126 to 207.4 nm, with PDI values between 0.119 and 0.312, indicating un Naringin, Phytosomes, Anti-inflammatory activity, Quality by Design. https://www.ijper.org/peanut-skin-extract-attenuates-doxorubicin-induced-myocardial-infarction-by-alle 2026-04-25T09:33:50.402624+00:00 Peanut Skin Extract Attenuates Doxorubicin Induced Myocardial Infarction by Alleviating Cardiac Inflammation, Oxidative Stress and Histological Changes in Wistar Rats 2026-01-06 10.5530/ijper.20267202 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-790.pdf Background: Cancer treatment is a major global concern. The anticancer drugs being used are effective, but their uses are curtailed due to ground: toxicity that they produce. Doxorubicin is one of the most efficient anti-cancer drugs, but its usage is also restricted due to cardio toxicity. Hence the demand of a drug is always there which can reduce toxicity and be used along with doxorubicin, thereby safeguarding myocardium during cancer treatment. Objectives: Thinking in the same direction we Peanut skin extract, Inflammation, Doxorubicin, Myocardial infarction, Oxidative stress. https://www.ijper.org/development-and-validation-of-uplc-pda-and-uv-methods-for-the-quantitative-estim 2026-04-25T09:34:49.920577+00:00 Development and Validation of UPLC-PDA and UV Methods for the Quantitative Estimation of Ascorbic Acid (ASAC) in Pharmaceutical Formulations 2026-01-06 10.5530/ijper.20261506 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-852.pdf Background: Vitamin C, also called Ascorbic Acid (ASAC), is a potent antioxidant that has a significant role in fighting infections and helps in healing wounds. Aim: Quantitative estimation of ASAC in formulations is of significance in quality control. A simple, sensitive, highly efficient and reliable Ultra-Performance Liquid Chromatography (UPLC) analytical method was suggested for evaluating ASAC in various pharmaceutical products (chewable tablet, effervescent tablets, and capsules). Materia UPLC, UV spectrophotometer, TLC, Vitamin C, Marketed formulation. https://www.ijper.org/development-and-validation-of-the-stability-indicating-rp-hplc-method-to-estimat 2026-04-25T09:35:01.810952+00:00 Development and Validation of the Stability-Indicating RP-HPLC Method to Estimate Olaparib in Graphene Quantum Dot Nanoformulation Using Analytical Quality by Design (AQbD) Principles 2026-01-06 10.5530/ijper.20261817 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-861.pdf Introduction: This study aimed to develop and validate a reliable Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) method for the accurate quantification of Olaparib in a Graphene quantum dot nanoformulation. The research employed the principles of Analytical Quality by Design (AQbD) to optimize and validate a stability-indicating RP-HPLC method. The primary objective was to optimize key chromatographic parameters, including retention time, theoretical plate count, and tailing fact Olaparib, Graphene Quantum dots, Central composite design, Quality by design, Force Degradation. https://www.ijper.org/virtual-workshop-on-antibiotic-use-and-resistance-for-malaysian-secondary-school 2026-04-25T09:35:43.096626+00:00 Virtual Workshop on Antibiotic Use and Resistance for Malaysian Secondary School Students 2026-01-06 10.5530/ijper.20261587 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-2-895.pdf Background: Antibiotic-resistant infections, which cause significant global morbidity and mortality, are exacerbated by inadequate knowledge about antibiotic use, highlighting the need for improved education to prevent resistance. The e-Bug educational workshop potentially mitigates the global threat of Antibiotic Resistance (ABR). Aim: This study evaluated the effectiveness of the virtual e-Bug workshop on antibiotic Awareness and Knowledge, and Practice (AKP) among Malaysian secondary school s Antibiotic resistance, Awareness, Educational workshop, Knowledge, Practice. https://www.ijper.org/article/60/3/1342-1350 2026-04-30T11:16:14.613577+00:00 Influence of Schisandrin A on Serum TNF-α, IL-1β, D-Lactic Acid, Diamine Oxidase and Colonic Tissue Oxidative Stress Markers in a Murine Model of Ulcerative Colitis 2026-01-01 10.5530/ijper.20260541 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-3-1342.pdf Introduction: This study was to demonstrate the potential roles and effects of Schisandrin A in the therapy of Ulcerative Colitis (UC). Materials and Methods: 60 mice from the China Experimental Animal Center were purchased and the mice were assigned to Group A (normal control), Group B (UC model), Group C1 (80 mg/kg Schisandrin A), Group C2 (40 mg/kg Schisandrin A), Group C3 (20 mg/kg Schisandrin A) and Group D (sulfasalazine), each comprising 10 individuals. An UC model was established and var Inflammatory factors, Oxidative stress, Schisandrin A, Ulcerative colitis https://www.ijper.org/natural-product-goniothalamin-induced-nadph-diaphorase-expression-in-the-liver-a 2026-04-28T06:00:00.840218+00:00 Natural Product Goniothalamin Induced NADPH-Diaphorase Expression in the Liver: A Possible Role of Nitric Oxide in Hepatoprotection 2025-12-20 10.5530/ijper.20256291 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-276.pdf Background/Aim: Goniothalamin (GTN) has received significant attention for its selective cytotoxicity toward multiple tumor cell lines, without causing any effect on normal cells. Despite a lack of toxicity, the poor potency of GTN hinders its clinical development. The existing in vivo data are also insufficient to support that GTN does not have effect on healthy cells. This prompted us to investigate whether GTN may produce any changes on healthy cells in the organs of mice especially liver as NADPH-d, Nitric oxide, Goniothalamin, Betulinic acid, Mice, Liver https://www.ijper.org/mitigation-of-insulin-resistance-inflammation-oxidative-stress-and-metabolic-abn 2026-04-28T05:01:11.240001+00:00 Mitigation of Insulin Resistance, Inflammation, Oxidative Stress, and Metabolic Abnormalities by Bavachalcone in High-Fat/High-Fructose Diet-Fed Rats 2025-12-20 10.5530/ijper.20257230 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-134.pdf Background: Obesity is defined by an excess of body fat, together with insulin resistance and dyslipidemia. These factors significantly elevate the risk of acquiring chronic disorders such as Diabetes Mellitus (DM), cardiovascular diseases, neurological disorders, etc. Objectives: The goal of the current study was to evaluate bavachalcone's beneficial effects on insulin resistance and obesity in experimental rats fed a High-Fat and High-Fructose (HFa-HFr) diet. Materials and Methods: The metabol Metabolic syndrome, Fatty liver, Bavachalcone, Insulin resistance, Inflammation https://www.ijper.org/blockade-of-multiple-pathways-of-p-falciparum-by-quinoxaline-from-curry-fish-s-h 2026-04-28T06:08:53.522491+00:00 Blockade of Multiple Pathways of P. falciparum by Quinoxaline from Curry Fish (S. hermanni) Using an in silico Approach 2025-12-20 10.5530/ijper.20255346 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-326.pdf Introduction: The escalating mortality and morbidity rates due to malaria present an unsolved global health problem. Previous in vivo research has revealed the antimalarial effect of S. hermanni. However, the mechanism of quinoxaline inhibition from curry fish against P. falciparum remains unknown, prompting this in silico investigation to identify inhibition pathways. Objectives: This study aims to uncover the inhibitory mechanism pathways of quinoxaline from S. hermanni against numerous protei Quinoxaline, Curry fish, In silico, P. falciparum, Antimalarial https://www.ijper.org/anticancer-apoptotic-cell-migration-and-invasion-inhibition-and-in-silico-molecu 2026-04-28T05:27:30.598986+00:00 Anticancer, Apoptotic, Cell Migration and Invasion Inhibition and in silico Molecular Docking Studies of Naringetol in A-549 Human Lung Cancer Cells 2025-12-20 10.5530/ijper.20250091 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-221.pdf Aims: The main objective of this research work was to investigate the anticancer effects of Naringetol in A-549 human lung cancer cells along with evaluating its effects on cell apoptosis, cell migration and cell invasion and decoding the molecular mechanism of action by studying interactions of this molecule with the target protein using in silico molecular docking studies. Materials and Methods: MTT assay was used to study effects on cell viability while as effects on cell colony was evaluate Naringetol, Lung cancer, Cell apoptosis, Cell migration, Cell invasion https://www.ijper.org/peiminine-alleviates-breast-carcinoma-via-reprogramming-the-pi3kaktmtor-pathway 2026-04-28T05:24:05.985175+00:00 Peiminine Alleviates Breast Carcinoma via Reprogramming the PI3K/Akt/mTOR Pathway in vitro and in vivo 2025-12-20 10.5530/ijper.20255151 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-210.pdf Background: The breast cancer is most frequently diagnosed cancer in the women worldwide. Our study investigated the anticancer effect of peiminine, an alkaloid obtained from Fritillaria thunbergii, against breast carcinoma. Materials and Methods: The toxicity study investigated LD50 and the subsequent doses of peiminine for carcinogenic study. The in vitro chemotherapeutic assessment was performed on MCF7 cells through MTT assay and flow cytometry. The breast cancer was developed in rats via in Peiminine, Apoptosis, Breast carcinoma, Chemotherapy, Cell proliferation https://www.ijper.org/apocynin-induces-apoptosis-in-human-lung-cancer-a549-cells-via-regulating-apopto 2026-04-28T05:34:16.052231+00:00 Apocynin Induces Apoptosis in Human Lung Cancer A549 Cells via Regulating Apoptotic Protein and Inflammatory Cytokines 2025-12-20 10.5530/ijper.20250045 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-242.pdf Objectives: Lung cancer, widely considered the leading cause of cancer-related deaths world wide, ranks fourth in terms of its occurrence among all types of malignant tumors. Phytochemicals are the potent alternative for these chemotherapeutic drugs. They have proven to render anticancer effects against various cancers such as breast, liver, brain, lung, skin, bone etc., in vivo, in vitro and even in clinical phase trials. One such phytochemical is apocynin, polyphenolic compound obtained from t Lung cancer, Phytochemical, Apocynin, A549 cells, Apoptosis, Inflammation https://www.ijper.org/spectral-characterization-antioxidant-and-antibacterial-activities-of-cold-metha 2026-04-28T05:15:36.035137+00:00 Spectral Characterization, Antioxidant and Antibacterial Activities of Cold Methanolic Extract of Sweet Basil (Ocimum basilicum L.) Leaves Growing in Jazan, Kingdom of Saudi Arabia 2025-12-20 10.5530/ijper.20250719 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-175.pdf Background: This study evaluated the chemical composition, antioxidant activity and antibacterial properties of methanol extracts of Ocimum basilicum L. leaves that were gathered from the Kingdom of Saudi Arabia's Jazan province. Materials and Methods: The extract was examined using FTIR and GC-MS techniques, which revealed the presence of terpenes (53.14%), Linalool (24.5%), sulfoxides (4.19%), cinnamic acid (5.23%), fatty acid esters (1.45%) and phthalic acid esters (0.72%). Results: The extra Ocimum basilicum, Sweet Basil, Ftir Spectroscopy, GC-MS, Antioxidant Activities, Antibacterial Activities https://www.ijper.org/propofol-inhibits-oxidative-stress-induced-neuronal-cell-ferroptosis-and-promote 2026-04-28T05:21:28.660341+00:00 Propofol Inhibits Oxidative Stress-Induced Neuronal Cell Ferroptosis and Promotes Synaptic Plasticity via the AMPK/ SIRT1/PGC-1α Axis 2025-12-20 10.5530/ijper.20250931 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-185.pdf Aim/Background: Propofol, recognized for its quick and effective action as a hypnotic anesthetic, is frequently utilized in clinical practice. Our research intended to investigate the mechanism by which propofol inhibits neuronal ferroptosis and promotes synaptic plasticity via mitochondrial energy regulation. Materials and Methods: Mouse Hippocampal Neurons (HT22) cells were treated with RAS-Selective Lethal 3 (RSL3) and propofol followed by Reactive Oxygen species (ROS) detection. Expression l Ferroptosis, Oxidative stress, Propofol, Synaptic plasticity https://www.ijper.org/research-on-the-application-of-the-bopppsblended-teaching-model-in-a-food-bioche 2026-04-28T04:47:52.242239+00:00 Research on the Application of the “BOPPPS+Blended Teaching” Model in a “Food Biochemistry” Course 2025-12-20 10.5530/ijper.20253755 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-56.pdf Background: Massive Online Open Course (MOOC) provides a new research idea and direction for educational reform with the internet era. The authors designed a “BOPPPS+blended teaching” model and carried out the practice in a “Food Biochemistry” course in order to improve the learning effect. Materials and Methods: 42 students in grade 2018 (experimental group) were divided randomly into seven groups (six students in each group) and taught using a “BOPPPS+blended teaching” model. The forty-two stu Food Biochemistry, BOPPPS, SPOC, Blended teaching https://www.ijper.org/evaluation-of-hepatoprotective-potential-of-bougainvillea-spectabilis-extracts-a 2026-04-28T06:18:27.477625+00:00 Evaluation of Hepatoprotective Potential of Bougainvillea spectabilis Extracts against CCl4-Induced Hepatotoxicity 2025-12-20 10.5530/ijper.20250293 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-377.pdf Background: Injuries and fatalities caused by liver disease are among the highest in the globe. Every year, more than one million people lose their lives due to chronic hepatitis, which affects an estimated 500 million people worldwide. In order to create liver disease treatments that can successfully cure or slow the illness's progression without side effects, new approaches are needed. Objectives: The present study's aim is to examine and confirm the buffering properties of Bougainvillea spect Bougainvillea spectabilis, Carbon Tetrachloride, Hepatopathy, SGPT, SGOT https://www.ijper.org/neuroprotective-potential-of-marrubium-vulgare-linn-extract-against-scopolamine 2026-04-28T06:04:03.855756+00:00 Neuroprotective Potential of Marrubium vulgare Linn. Extract against Scopolamine-Induced Alzheimer’s Type Dementia in Mice 2025-12-20 10.5530/ijper.20255860 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-297.pdf Background: Alzheimer's Disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment, cognitive decline and behavioural changes. It primarily affects individuals over the age of 65. It poses a substantial global health burden, with an increasing prevalence among the elderly population. Although the exact aetiology of AD is complex and multifactorial, emerging evidence suggests that dysfunction of glutamatergic neurotransmission, particularly involving the N-Methyl- Alzheimer’s Disease, Glutamate, Neurotransmitter, Oxidative stress, Marrubium vulgare https://www.ijper.org/therapeutic-potential-of-plant-based-hmg-coa-reductase-inhibitor-berberine-for-a 2026-04-28T05:05:18.081726+00:00 Therapeutic Potential of Plant Based HMG CoA Reductase Inhibitor-Berberine for Alzheimer’s Disease in ICV Induced Streptozotocin Rodent Model 2025-12-20 10.5530/ijper.20255856 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-153.pdf Background: Alzheimer's Disease (AD), is a progressive neurodegenerative disease, that results in memory loss, cognitive impairment and behavioral abnormalities. It is one of the most widely spread diseases and is common among elders. In AD there is an increase in the generation of ROS, RNS and phosphorylation of TAU. As a result, efforts to produce AD medications have centered on lowering the levels of Aβ (Amyoid β). Cholesterol stabilizes β-secretase and γ-secretase and promotes amyloidogenesi Alzheimer’s disease, Aβ, Donepezil, Berberine, Streptozotocin https://www.ijper.org/mir-142-5p-suppresses-ovarian-cancer-metastasis-by-inhibiting-the-epithelial-mes 2026-04-28T05:09:31.634007+00:00 Mir-142-5p Suppresses Ovarian Cancer Metastasis by Inhibiting the Epithelial-Mesenchymal Transition via DNMT1 2025-12-20 10.5530/ijper.20251283 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-164.pdf Aim/Background: Ovarian Cancer (OC) accounts for the highest number of deaths among gynecological cancers. Our research is focused on investigating the therapeutic potential and the fundamental mechanism by which miR-142-5p exerts its effects in the treatment of OC. Materials and Methods: The GSE53829 and GSE83693 data sets were collected for targeted miRNA identification. RT-qPCR was conducted to evaluate the expression levels of miRNA, N-cadherin, ZO-1, Claudin-1, E-cadherin, and DNMT1 mRNA ex DNMT1, EMT, Metastasis, miR-142-5p, Ovarian Cancer https://www.ijper.org/anti-atherosclerotic-potency-of-lichen-metabolite-usnic-acid-against-high-fat-di 2026-04-28T05:43:48.228541+00:00 Anti-Atherosclerotic Potency of Lichen Metabolite Usnic Acid against High Fat Diet Induced Atherosclerosis Rat Model 2025-12-20 10.5530/ijper.20257128 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-264.pdf Background: Cardiovascular diseases and its associated chronic disorders are was and tend to be a global threat for centuries. 80% of cardiovascular diseases were reported in the lower and middle income countries. Chronic atherosclerosis, a chronic circulatory disorder occurs due to the platelet aggregation, thrombosis formation and eventually rupture of atherosclerotic plaque causes excessive mortalities and morbidities worldwide. Previously elderly people were at risk of cardiovascular disease Atherosclerosis, High fat diet, Inflammation, Dyslipidemia, Usnic acid https://www.ijper.org/a-study-on-the-mechanism-of-herb-partitioned-moxibustion-at-the-navel-based-on-t 2026-04-28T06:24:36.620768+00:00 A Study on the Mechanism of Herb-Partitioned Moxibustion at the Navel Based on the Gut-Brain Axis Theory in the Prevention and Treatment of Insomnia via the BDNF/TrkB Pathway 2025-12-20 10.5530/ijper.20251193 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-392.pdf Aim/Background: To examine the impact of navel moxibustion, a form of herb-partitioned moxibustion applied at the belly button, on Brain-Derived Neurotrophic Factor (BDNF), Tyrosine Kinase receptor B (TrkB) and 5-Hydroxytryptamine (5-HT) levels in rats with PCPA-induced insomnia. Additionally, to investigate the mechanism by which navel moxibustion improves insomnia. Materials and Methods: 27 Specific Pathogen Free (SPF)-grade male three-monthold SD rats were randomly divided by weight into the 5-hydroxytryptamine (5-HT), Brain-Derived Neurotrophic Factor (BDNF), Insomnia, Tyrosine Kinase receptor B (TrkB) https://www.ijper.org/lidocaine-alleviates-myocardial-ischemia-reperfusion-injury-in-rats-through-jnk 2026-04-28T06:27:08.566333+00:00 Lidocaine Alleviates Myocardial Ischemia-Reperfusion Injury in Rats through JNK Signaling Pathway 2025-12-20 10.5530/ijper.20250322 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-400.pdf Aim/Background: This study aimed to explore the impact of lidocaine on rats subjected to MIR injury and to elucidate the underlying mechanisms involved in this process. The objective was to examine how lidocaine affects the physiological and biochemical responses in these rats, providing insights into its potential therapeutic benefits and the specific pathways through which it exerts its effects. Materials and Methods: 30 Sprague-Dawley rats were randomly divided into three groups: a sham group C-Jun N-terminal kinase, Myocardial ischemia-reperfusion, Lidocaine, Rats https://www.ijper.org/use-of-liquid-solid-technique-for-development-and-evaluation-study-of-nifedipine 2026-04-28T06:22:59.914533+00:00 Use of Liquid Solid Technique for Development and Evaluation Study of Nifedipine Tablets to Enhance Dissolution Characteristics 2025-12-20 10.5530/ijper.20255571 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-384.pdf Objectives: The current research finding suggests dissolution enhancement of nifedipine tablets using Liquid solid technique. Materials and Methods: The drug's solubility in various liquid carriers has been examined, out of which drug shows maximum solubility in PEG 400 which acts non-volatile liquid solvents. The prepared mixture dissolved with Avicel PH 102 which acts as carrier and Aerosil 200 acts as coating material using formula for Liquid Load Factor (Lf ). The blend is then mixed with di BCS class II, Nifedipine, Liquisolid Technique, Dissolution rate, PEG 400, Liquid Load Factor https://www.ijper.org/structural-elucidation-of-phytoconstituents-phenols-long-chain-fatty-acids-flavo 2026-04-28T06:05:36.179674+00:00 Structural Elucidation of Phytoconstituents (Phenols, Long Chain Fatty Acids, Flavonoid, Terpenoids, Coumarin) Found in Chromolaena odorata through Gas Chromatography: Mass Spectroscopy (GC-MS) Technique 2025-12-20 10.5530/ijper.20254846 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-308.pdf Background:Chromolaena odorata (CO) is a well-known ethnopharmacological herb in Ayurveda and exhibits a comprehensive range of therapeutic potential. Objectives: The objective of this research was to study the phytochemical profile of ethanolic extract of CO by Gas Chromatography Mass Chromatography (GC-MS) analysis. Materials and Methods: Ethanolic extract of CO was prepared by soxhlet extraction and the extract was subjected to GC-MS analysis (Agilent 7890A GC System) for chemical characteriz Chromolaena odorata, Phytoconstituents, Phenol, Flavonoid, Terpenoids, LCFA https://www.ijper.org/evaluation-of-antipyretic-and-antioxidant-activities-of-ten-indigenous-medicinal 2026-04-28T05:41:35.559267+00:00 Evaluation of Antipyretic and Antioxidant Activities of Ten Indigenous Medicinal Plants of Tirtajaya, Karawang Regency, West Java, Indonesia 2025-12-20 10.5530/ijper.20256381 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-252.pdf Aim: This research aimed to explore the antipyretic and antioxidant activity of infusions of Chromolaena odorata (COI), Abelmoschus manihot (AMI), Annona muricata (AMCI), Allium ascalonicum (AAI), Carica papaya (CPI), Tamarindus indica (TII), Zingiber officinale (ZOI ), Abrus precatorius (API), Momordica charantia (MCI) and Strobilanthes crispus (SCI). Materials and Methods: The antipyretic activity of plant infusions was tested using a peptone-induced rat model. The male rat used were divided i Antipyretic, Antioxidant, Medicinal plants, Peptone-induced rat model, DPPH https://www.ijper.org/hepatoprotective-properties-of-acacia-nilotica-bark-extract-against-h2o2-induced 2026-04-28T06:16:04.438975+00:00 Hepatoprotective Properties of Acacia nilotica Bark Extract against H2O2 Induced Oxidative Damage in Normal Liver (LO2) and Cancer (HepG2) Cells 2025-12-20 10.5530/ijper.20256767 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-370.pdf Background: Liver cancer's severity has prompted interest in herbal remedies for hepatotoxicity and the disease. Acacia nilotica (Vachellia nilotica), valued for its traditional medicinal properties, particularly in its aerial components, is being investigated for its hepatoprotective and anti-cancer effects. However, research on A. nilotica bark extracts and their mechanisms of action is limited. Materials and Methods: The study aimed to determine the Total Phenolic Content (TPC), Total Flavono A. nilotica, cytotoxic, DPPH, H2O2, HepG2, LO2 https://www.ijper.org/conessine-attenuates-diabetic-nephropathy-in-rats-through-inhibition-of-hypergly 2026-04-28T06:14:56.552719+00:00 Conessine Attenuates Diabetic Nephropathy in Rats through Inhibition of Hyperglycemia-Induced Oxidative Stress, Inflammation and Apoptosis 2025-12-20 10.5530/ijper.20250182 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-359.pdf Background: One type of chronic kidney disease is diabetic nephropathy. One of the main causes of end-stage renal disease and chronic kidney disease is diabetic nephropathy. The objective of this study was to assess the effects of treating diabetic nephropathy with conessine extract on male wistar rats with diabetes that had been triggered by streptozotocin. Materials and Methods: Twenty-four rats were split up into four groups. The regular diet was fed to the negative control animals in the fi Conessine, Diabetic nephropathy, Streptozotocin, Antioxidants https://www.ijper.org/the-effect-of-pistacia-vera-l-pistachio-extract-on-fatty-acid-biosynthesis-and-t 2026-04-28T06:13:13.148458+00:00 The Effect of Pistacia vera L. (Pistachio) Extract on Fatty Acid Biosynthesis and Total Proteins against Carbon Tetrachloride (CCl4)-induced Damage in Saccharomyces cerevisiae 2025-12-20 10.5530/ijper.20257396 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-351.pdf Background and Aim: Pistacia vera (PV) is an important species with economic value, rich compound content and high biological activity. Carbon Tetrachloride (CCl4 ) used in our study is an important reactive toxic compound. Saccharomyces cerevisiae is often used as an important cell model in xenobiotic, toxicological and biochemical studies. This research, fatty acid contents of Pistacia vera cultivated in Kilis province, the effects of this content on fatty acid profile and total proteins in CC Pistacia vera, CCl4, Saccharomyces cerevisiae, Fatty acids, Total protein https://www.ijper.org/in-vitro-study-on-the-antioxidant-and-anti-inflammatory-capabilities-of-borassus 2026-04-28T06:07:46.256337+00:00 In vitro Study on the Antioxidant and Anti-Inflammatory Capabilities of Borassus flabellifer Seedcoat 2025-12-20 10.5530/ijper.20255122 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-316.pdf Aims: Borassus flabellifer, commonly known as Palmyra palm, Ice apple, Nungu (Tamil) is prevalent in South Asia. This study is focused on determining the anti-oxidant and anti-inflammatory activity of ethanolic extract isolated from the seedcoat of Borassus flabellifer. Materials and Methods: The ethanolic extract of Borassus flabellifer seedcoat was prepared by cold extraction technique using sterile filter paper. The in vitro antioxidant activity was assessed using 2,2-Diphenylpicrylhydrazyl Anti-oxidant, Anti-inflammatory, Borassus flabellifer, Ethanolic extract, Ice apple, Seed coat https://www.ijper.org/effect-of-evodiamine-in-the-prevention-and-treatment-of-5-fu-induced-diarrhea-in 2026-04-28T06:01:31.771642+00:00 Effect of Evodiamine in the Prevention and Treatment of 5-FU Induced Diarrhea in Swiss Albino Rats: A Preliminary Study 2025-12-20 10.5530/ijper.20250135 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-287.pdf Aim of the Study: To assess the antidiarrheal properties of Evodiamine in the prevention and treatment of Chemotherapy-Induced Diarrhea (CID) in experimental rats. Materials and Methods: The Swiss albino female rats (8-12 weeks) rats were treated with Evodiamine for 13 days and 5-FU was administered on day 4 to day 10 (7 consecutive days) for the induction of diarrhea. After 13 days of experiments, all rats were euthanized and thymus and spleen weights were measured. Bodyweight and diarrhea ra Evodiamine, Chemotherapy, Diarrhea, Phytomedicine, Swiss albino rat, in vivo https://www.ijper.org/acetyl-11-keto-boswellic-acid-loaded-ethosomes-as-nanocarriers-from-a-physicoche 2026-04-28T04:52:14.153476+00:00 Acetyl-11-Keto-β-Boswellic Acid-Loaded Ethosomes as Nanocarriers from a Physicochemical Perspective and in vivo Evaluation 2025-12-20 10.5530/ijper.20254420 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-82.pdf Background: Ethosomes are elastic nanovesicles made of phospholipids that contain a high concentration of ethanol. It has shown to improve the skin permeability of many drugs due to interactions between the high ethanol. Materials and Methods: The optimization and characterization of 3-Acetyl-11-Keto-β-Boswellic Acid (AKBA) loaded vesicular ethosomes included measurements of particle size, entrapment effectiveness, microscopy using SEM and TEM, and the interaction of the drug and excipients usin Ethosomes, Transdermal flux, Acetyl-11-keto-beta-boswellic acid, Lipid-based vesicles, Permeation enhancers https://www.ijper.org/assessing-the-pharmacological-potential-of-thymoquinone-for-managing-alcohol-cra 2026-04-28T04:56:12.22803+00:00 Assessing the Pharmacological Potential of Thymoquinone for Managing Alcohol Craving and Withdrawal Syndrome in Mice 2025-12-20 10.5530/ijper.20250194 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-101.pdf Aim/Background: The aim is to evaluate THMQ's impact on alcohol withdrawal and alcohol craving using an animal model. Mice were exposed to increasing ethanol doses to simulate dependency. Researchers assessed anxiety levels during withdrawal using behavioural and biochemical tests. THMQ was administered orally at 20 mg/kg and 40 mg/kg, compared to diazepam (1 mg/kg). Materials and Methods: Model Creation Mice received escalating ethanol doses (5% to 35% v/v) over specific days. Regular water was Alcohol Craving, Alcohol Withdrawal, Thymoquinone, Western blot, Open Field Test https://www.ijper.org/protective-effects-of-lysergol-against-complete-freund-adjuvant-induced-rheumato 2026-04-28T05:02:39.519429+00:00 Protective Effects of Lysergol against Complete Freund Adjuvant-Induced Rheumatoid Arthritis in Rats 2025-12-20 10.5530/ijper.20250039 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-144.pdf Background: Rheumatoid Arthritis (RA) is a rapidly developing autoimmune disease caused by self-destruction of the immune system, resulting in deformed joints and erosion of the bones. In the current study, we explored the anti-arthritic impact of Lysergol against the Complete Freund Adjuvant (CFA)-stimulated arthritis in rat model. Materials and Methods: Administration of CFA was performed for inducing arthritis and the animals were divided into 4 distinct groups. The rats then received Lysergo Arthritis, Lysergol, Complete Freund adjuvant, Anti-inflammatory, Inflammatory cytokines https://www.ijper.org/a-comprehensive-qbd-study-on-bioadhesive-ocular-films-for-improved-conjunctiviti 2026-04-28T05:01:24.75599+00:00 A Comprehensive QbD Study on Bioadhesive Ocular Films for Improved Conjunctivitis Management: Insights from Design Expert Software 2025-12-20 10.5530/ijper.20255680 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-122.pdf Objectives: The study aimed to develop ocular films containing levofloxacin to treat conjunctivitis. These films were meticulously prepared using a combination of Gelatin, Aloe barbadensis leaves mucilage, and HPMC K4M, by the solvent casting technique, with the primary objective of enhancing the therapeutic efficacy of levofloxacin for this specific eye condition. Materials and Methods: A comprehensive evaluation was carried out to ensure the quality and reliability of the films, encompassing p Biodegradable, Eye, Film, Levofloxacin, Ocular https://www.ijper.org/heralding-a-new-era-for-higher-education-institutes-moving-towards-implementatio 2026-04-28T04:46:13.028751+00:00 Heralding a New Era for Higher Education Institutes: Moving Towards Implementation of National Education Policy 2020: A Pharmacy Undergraduate Program Perspective 2025-12-20 10.5530/ijper.20250760 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-46.pdf The National Education Policy (NEP) 2020 has been drafted to bring about a paradigm shift in the prevailing system of education at the school and higher educational levels (Undergraduate and Post graduate Degree programs). The NEP 2020 policy has been designed to ensure that education is reachable to all learners who can avail it at their own pace and according to their needs. Taking academic breaks which was previously unheard of in the Indian education scenario has been made plausible via the Pharmacy Course Structure, Pharmacy Council of India, National Education Policy, 2020, University Grants Commission, Credits https://www.ijper.org/next-gen-post-diagnostic-care-through-centralized-ai-and-smart-wearable-devices 2026-04-28T04:45:23.122445+00:00 Next-Gen Post-Diagnostic Care through Centralized AI and Smart Wearable Devices for Chronic Disease Management: A Narrative Review 2025-12-20 10.5530/ijper.20250207 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-37.pdf This article presents a futuristic framework for incorporating centralized AI to revolutionize patient care, focusing on the post-diagnostic care andmanagement of various chronic conditions.Through the integration of centralized AI with remote monitoring devices, smart wearables and home appliances, a futuristic approach to post-diagnostic care is proposed, serving diverse needs of patients with cardiovascular diseases, diabetes mellitus and sleep disturbances. By employing the power of AI, heal Artificial Intelligence, Smart wearables, Remote monitoring, Chronic disease management, Data analysis, Patient care management https://www.ijper.org/design-and-characterization-of-herbal-transdermal-patch-containing-capsaicin-ext 2026-04-28T04:50:27.519655+00:00 Design and Characterization of Herbal Transdermal Patch Containing Capsaicin Extract and Mustard Oil for Arthritis 2025-12-20 10.5530/ijper.20255973 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-74.pdf Introduction: Arthritis, a chronic inflammatory condition causing significant pain and diminished quality of life, affects millions worldwide. This study aimed to develop and characterize a novel herbal transdermal patch using mustard oil and capsaicin extract, extracted via water, alcohol, and mustard oil. The extracts underwent preliminary examination and were assessed for in vitro anti-inflammatory activity. Objectives: The primary goal was to construct and evaluate a transdermal patch for ar Transdermal patch, Capsaicin extract, In vitro and ex vivo permeation study, Docking study, Arthritis https://www.ijper.org/laser-induced-breakdown-spectroscopy-a-promising-analytical-technique 2026-04-28T04:42:59.265041+00:00 Laser Induced Breakdown Spectroscopy: A Promising Analytical Technique 2025-12-20 10.5530/ijper.20254665 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-30.pdf Laser Induced Breakdown Spectroscopy (LIBS) is a rapid analytical technique. It has become an established analytical atomic spectrometry technique for the analysis of various samples. This method is widely used for determination of the elemental composition of various solids, liquids and gases as well as for the characterization and identification of the material. This technique is based on the optical detection of certain molecular and atomic species. Present review article aims to provide all Laser Induced Breakdown Spectroscopy, Calibration Free Laser Induced Breakdown Spectroscopy, Analytical technique, Laser Induced Plasma Spectroscopy, Laser Spark Spectroscopy https://www.ijper.org/fabrication-and-evaluation-of-floating-zidovudine-microbeads-for-prolonged-kinet 2026-04-28T04:49:16.472979+00:00 Fabrication and Evaluation of Floating Zidovudine Microbeads for Prolonged Kinetic Release and Bioavailability 2025-12-20 10.5530/ijper.20254139 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-65.pdf Aim: AIDS (Acquired Immuno Deficiency Syndrome) is one of the most sexually transmitted diseases with chronic depletion of immunity in the body associated with social stigma, social isolation and depression. Zidovudine is an orally prescribed antiretroviral drug for AIDS. The current work's objective was to develop floating microbeads of zidovudine to achieve sustained release action. Floating microbeads are a non-effervescent, gastro-retentive drug delivery technology that has been designed to Microbeads, Sustained, Zidovudine, Floating, Gastro-retentive https://www.ijper.org/an-insight-into-the-synthetic-strategies-and-pharmacological-effects-of-cinnolin 2026-04-28T04:40:23.665646+00:00 An Insight into the Synthetic Strategies and Pharmacological Effects of Cinnoline Derivatives 2025-12-20 10.5530/ijper.20253735 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-13.pdf Background: The cinnoline ring is a new aromatic heterocyclic connected with two nitrogen atoms in a 6 membered ring and compounds containing this ring have been shown to have a wide variety of pharmacologicaleffects. Objectives: This review studyextensively explains the synthetic strategy by which researchers have produced cinnoline derivatives reported to have numerous pharmacological effects, including antitubercular, antibacterial, anticancer, antimolluscidal, etc. Materials and Methods: The Cinnoline, Aromatic, Synthesis, Pharmacokinetic, Heterocyclic, Pharmacological effects https://www.ijper.org/elucidating-potential-of-dietary-pufas-3-in-tackling-cytokine-storm-syndrome-by 2026-04-28T04:40:31.381486+00:00 Elucidating Potential of Dietary PUFAs (Ω-3) In Tackling Cytokine Storm Syndrome by Attenuation of Pro-Inflammatory Cytokines 2025-12-20 10.5530/ijper.20257024 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-1.pdf Background: The study aims to examines PUFAs precisely ω-3 potential in tackling Cytokine storm syndrome. Study also investigates PUFAs: ω-3 in regulation of pro-inflammatory and anti-inflammatory cytokines associated with acute respiratory distress syndrome during respiratory viral infections. Materials and Methods: To find the most relevant studies, an in-depth review of the literature published in PubMed, Embase, the Cochrane library and China National Knowledge Infrastructure (CNKI) was cond Cytokine Storm Syndrome, Respiratory Virus Infections, Acute Respiratory Distress Syndrome, Inflammatory Cytokines, Poly Unsaturated Fatty Acids, Omega 3 https://www.ijper.org/expression-of-helicobacter-pylori-caga-in-solanum-melongena-l-a-cost-effective-s 2026-04-28T05:21:21.859306+00:00 Expression of Helicobacter pylori CagA in Solanum melongena L-A Cost Effective Strategy for Vaccine Development 2025-12-20 10.5530/ijper.20250081 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-196.pdf Background: Helicobacter pylori is implicated in several severe gastrointestinal disorders, including gastric cancer, affecting a significant global population. This study aims to exploit plant biotechnology for vaccine development by engineering brinjal (Solanum melongena L.) to express H. pylori’s cytotoxin-associated gene A (cagA) antigen. Utilizing transgenic plants as an innovative strategy not only mitigates the high costs associated with traditional vaccine production but also leverages t Helicobacter pylori, Transgenic brinjal, cagA antigen, Edible vaccines https://www.ijper.org/enhancing-therapeutic-potential-investigating-traditional-detoxification-methods 2026-04-28T05:31:28.25006+00:00 Enhancing Therapeutic Potential: Investigating Traditional Detoxification Methods and Assessing their Influence on Anti-Microbial Efficacy, Phytochemical Composition, Heavy Metal Content and Anti-inflammatory Properties in Trachyspermum ammi 2025-12-20 10.5530/ijper.20250286 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-230.pdf Background: Trachyspermum ammi (T. ammi) holds a longstanding position in traditional medicinal practices, renowned for its diverse medicinal and pharmacological attributes. Medicinal plants not only offer significant therapeutic benefits but also hold economic importance. A noteworthy trait of phytomedicine lies in its low toxicity, which positively impacts the pharmaceutical market. Hence, traditional practices often incorporate detoxification/purification methods to mitigate the toxicity of h Detoxification, Phytochemical Composition, Anti-inflammatory, Trachyspermum ammi https://www.ijper.org/punicalagin-inhibits-cell-growth-and-promotes-apoptosis-in-bladder-cancer-t24-ce 2026-04-28T04:57:35.047681+00:00 Punicalagin Inhibits Cell Growth and Promotes Apoptosis in Bladder Cancer T24 Cells via Upregulating Oxidative Stress and Apoptotic Marker Expressions 2025-12-20 10.5530/ijper.20257390 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-112.pdf Background: Bladder cancer is a prevalent form of cancer worldwide and is associated with increased rates of mortality. Objectives: The present investigation focuses on understanding the inhibitory activities of punicalagin on the viability and promotion of apoptosis in T24 bladder cancer cells. Materials and Methods: The punicalagin at diverse concentrations (1-15 μM) was tested for its in vitro free radical scavenging effects, including DPPH, superoxide and peroxyl radicals. The effects of pun Apoptosis, Oxidative stress, Caspases, Punicalagin, Bladder cancer https://www.ijper.org/development-and-validation-of-a-high-performance-liquid-chromatographic-method-f 2026-04-28T04:53:53.250173+00:00 Development and Validation of a High-Performance Liquid Chromatographic Method for Content Assay of Ceftriaxone in Pharmaceutical Dosage 2025-12-20 10.5530/ijper.20255575 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-94.pdf Aim: A sensitive and accurate RP-HPLC method was developed and validated for the quantitative measurement of Ceftriaxone sodium (CEF) in pharmaceutical dosage forms and bulk medicine. Materials and Methods: Ceftriaxone sodium was separated on a 245 nm photodiode array detector using a Waters XTerra RP-18 (5 µm 250x4.6 mm internal diameter) column. Results: The method generated an excellent linear response in the concentration range of 0.2-20 µg/mL with remarkable precision of 0.16-0.7% and accur HPLC, Ceftriaxone, Bulk, Pharmaceutical, Dosage https://www.ijper.org/chemical-profiling-and-in-vitro-evaluation-of-the-antioxidant-anti-inflammatory 2026-04-28T06:11:39.659955+00:00 Chemical Profiling and in vitro Evaluation of the Antioxidant, Anti-Inflammatory, and Anti-Bacterial Effects of Algerian Solanum melongena L. 2025-12-20 10.5530/ijper.20250132 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1-338.pdf Aim: Solanum melongena L., commonly known as eggplant, is a low-calorie vegetable with high nutritional value due to its rich fiber, vitamins, minerals, and bioactive compounds, particularly polyphenols, which provide antioxidant properties. This study aimed to investigate the chemical composition and biological activities of methanolic extracts from purple S. melongena fruit. Materials and Methods: The chemical and biological properties of the methanolic extract were analyzed using both qualita Antioxidant, phenolic, Solanum melongena, Gas Chromatography-Mass Spectrometry https://www.ijper.org/dexamethasone-induced-osteoblast-toxicity-bioenergetics-dysfunction-and-oxidativ 2026-04-25T07:58:45.168398+00:00 Dexamethasone-Induced Osteoblast Toxicity: Bioenergetics Dysfunction and Oxidative Stress Unmask Apoptotic Pathways 2025-12-06 10.5530/ijper.20261072 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-261.pdf Aim: Dexamethasone (DEX) is a glucocorticoid commonly used to treat autoimmune and non-infectious inflammatory diseases; however, its role in inducing osteoporosis is poorly understood. Materials and Methods: This study investigates the effects of DEX on cell toxicity, secretory functions, mitochondrial bioenergetics, oxidative stress and apoptosis in human osteoblasts. Results: DEX-induced cell toxicity, as evidenced by elevated Lactate Dehydrogenase (LDH) and MTT assays, with an estimated EC50 Antioxidants, Bone, Dexamethasone, Mitochondria, Osteoblasts, Redox stress. https://www.ijper.org/probe-sonication-based-green-synthesis-agnps-using-p-guajava-leaves-extract-and 2026-04-25T07:58:45.079957+00:00 Probe Sonication-Based Green Synthesis AgNPs Using P. Guajava Leaves Extract and Anticancer Behavior MCF-7 Cell Lines 2025-12-06 10.5530/ijper.20261382 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-205.pdf Purpose: The present work is devoted to the green and probe sonication-based fabrication of AgNPs using the leaves extract of P. guajava. Materials and Methods: Various analytical techniques have been used to characterize the synthesized AgNPs, which examine significant chemical and physical characteristics of AgNPs. Results: The green synthesized AgNPs were used against a breast cancer cell line (MCF-7). The FTIR study indicates the presence of O-H, C=O, C=C, and C-Ag bonds on the surface of Ag AgNPs, Anticancer Activity, Green and probe ultrasonic-based synthesis, Leaves Extract, P. guajava. https://www.ijper.org/investigation-of-anti-cancer-potency-of-sarsasapogenin-in-vitro-and-in-silico-in 2026-04-25T07:58:44.648919+00:00 Investigation of Anti-Cancer Potency of Sarsasapogenin: In vitro and In silico Insights against MDR Cell Line-KB-Chr-8-5 2025-12-06 10.5530/ijper.20262682 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-212.pdf Objectives: Cancer recurrence is a major global concern, contributing to the rising mortality rates in the most common types of cancer. To overcome these incidents, highly qualified herbal medicines are more targetable, thus this investigation demonstrates the treatment of a steroidal bioactive compound-Sarsasapogenin (SAR). Materials and Methods: To achieve the goal, Anti-oxidant capacity of SAR was studied by DPPH and ABTS assay. Cytotoxicity assessment was performed as first line confirmation Sarsasapogenin, Multi drug resistant, KB-ChR-8-5, Cancer recurrence, ABCC1, MRP 1. https://www.ijper.org/development-of-a-new-validated-rp-hplc-method-for-simultaneous-estimation-and-st 2026-04-25T07:58:44.651009+00:00 Development of a New Validated RP-HPLC Method for Simultaneous Estimation and Stability Study of Tegafur, Gimeracil and Oteracil in Combined Dosage Form 2025-12-06 10.5530/ijper.20265079 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-336.pdf Aim: This study developed a validated and stability-analyzing Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) method for simultaneous determination of selected drugs Materials and Methods: Separation, quantification and degradation of the selected drugs and their degradation study was performed on Waters Alliance-e2695, with X Bridge phenyl column (150×4.6 mM, 3.5 μ) column, mixture of Acetonitrile (ACN) and 0.1% v/v trifluoroacetic acid (50:50% v/v) as mobile phase, flow rate of Gimeracil, Oteracil, RP-HPLC, Simultaneous, Stability studies, Tegafur. https://www.ijper.org/insulin-secretory-dysfunction-as-the-underlying-mechanism-of-diabetogenesis-in-n 2026-04-25T07:58:45.036892+00:00 Insulin Secretory Dysfunction as the Underlying Mechanism of Diabetogenesis in Neonatal Streptozotocin-Induced Type 2 Diabetes Model Rats 2025-12-06 10.5530/ijper.20266401 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-274.pdf Background: Neonatal Streptozotocin (n-STZ) rats are widely used as models for type 2 diabetes mellitus, but the basic defects of diabetes (insulin secretion and resistance) have not yet been adequately characterized in all species of such rats. Materials and Methods: In this study, the basic defects were studied in a group of neonatal streptozotocin-induced type-2 (n-2 STZ) diabetic models of Long Evans rats. The model rats were produced with a single intraperitoneal injection of streptozotocin Long Evans rats, Streptozotocin, Insulin secretory dysfunction, Insulin resistance, Lipids. https://www.ijper.org/unveiling-novel-insights-in-chronic-myeloid-leukemia-cell-lines-k562-through-in 2026-04-25T08:50:20.988913+00:00 Unveiling Novel Insights in Chronic Myeloid Leukemia Cell Lines K562 through in vitro and in silico Approach Targeting of Apoptosis and Oxidative Stress Pathways 2025-12-06 10.5530/ijper.20263903 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-358.pdf Introduction: Troxerutin (TR), bioflavanoid derived from rutin posess several biological activity like antioxidant, antinflammatory, antidiabetic and antitumor activity and found to be alternative candidate for cancer therapy. Chronic Myelogenous Leukaemia (CML) is a hematoproliferative disorder caused by uncontrolled myeloid cell division in bone marrow charecterized by Bcr and Abl gene fusion. This study aimed to evaluate the anticancer activity of TR on K562 chronic myeloid leukemia cell line Apoptosis, Caspases, Chronic Myelogenous leukaemia, Flavonoids, In silico, Troxerutin https://www.ijper.org/aiml-based-medical-devices 2026-04-25T08:48:08.118282+00:00 AI/ML-Based Medical Devices 2025-12-06 10.5530/ijper.20261314 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-371.pdf In order to manage health emergencies, develop universal health care, and encourage healthier communities, access to relevant, reasonably priced, and high-quality health products (including medical devices) is crucial. Without medical devices, it would be impossible to perform common medical procedures like bandaging a sprained ankle, diagnosing HIV/AIDS, implanting an artificial hip, or performing any kind of surgery. Read More.... Commentary https://www.ijper.org/development-and-validation-of-stability-indicating-liquid-chromatographic-method 2026-04-25T07:58:44.970389+00:00 Development and Validation of Stability Indicating Liquid Chromatographic Method for Simultaneous Estimation of Silodosin and Dutasteride in API and Combined Dosage Form 2025-12-06 10.5530/ijper.20265613 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-312.pdf Background: The proposed work was done with a view to develop a RP-HPLC approach for the concurrent quantification of Dutasteride and Silodosin in API and capsule formulation and validate it. Materials and Methods: A C18 Thermo BDS column (150×4.6 mM, 5 μM) was utilized, which also used buffer and acetonitrile as mobile phase (70:30 v/v) eluent A and (30:70 v/v) eluent B at flow rate of 1 mL/min. The samples were quantified at 250 nm employing a PDA detector. In compliance with ICH recommendatio Dutasteride, Forced Degradation, Simultaneous estimation, Stability Indicating RP-HPLC Method Silodosin. https://www.ijper.org/degradation-kinetics-and-characterization-of-canagliflozin-under-solution-stress 2026-04-25T07:58:44.64964+00:00 Degradation Kinetics and Characterization of Canagliflozin Under Solution Stress by LC and LC-MS/MS Method 2025-12-06 10.5530/ijper.20266836 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-320.pdf Objectives: Using the RP-HPLC method, this work investigates the degradation behavior of canagliflozin and its commercial formulation under ICH-recommended stress conditions. It also validates the suggested method and analyzes degraded samples’ solution state using LC-MS/MS. Materials and Methods: The solution-state degradation study of canagliflozin in tablet dosage form was performed using the Shimadzu-HPLC series 1100. The acetonitrile (50:50) v/v mobile phase, ammonium acetate buffer pH 4.5 Canagliflozin, Degradation, Kinetics, LC-MS/MS, Stability. https://www.ijper.org/potential-of-ethanol-extract-of-suruhan-leaves-peperomia-pellucida-l-kunth-in-re 2026-04-25T07:58:44.827844+00:00 Potential of Ethanol Extract of Suruhan Leaves (Peperomia pellucida L. Kunth) in Regulating TNF-α, VEGF and Histopathological Changes in Wounds in Mice with Diabetic Ulcers 2025-12-06 10.5530/ijper.20260761 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-229.pdf Background: Diabetes Mellitus (DM) is a chronic and progressive metabolic disorder characterized by an increase in blood glucose levels (hyperglycemia) because the pancreas does not produce enough insulin or the body is unable to use the insulin produced effectively. One of the complaints that occur in DM patients is the appearance of wounds that are difficult to heal or are called diabetic ulcers. Diabetic ulcers and gangrene cases in Indonesia are the most common cases encountered in hospitals Diabetic ulcers, Ethanol Extract Effect Suruhan Leaves, White rat, Wistar strain. https://www.ijper.org/reliability-of-virtual-objective-structured-clinical-examination-in-pharmacy-pra 2026-04-25T07:58:44.651143+00:00 Reliability of Virtual Objective Structured Clinical Examination in Pharmacy Practice Experience Education Using Generalizability Theory 2025-12-06 10.5530/ijper.2021159 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-344.pdf Background and Objectives: The virtual Objective Structured Clinical Examination (OSCE) was established using the MyDispense database in various pharmacy schools worldwide. However, rigorous reliability estimation is lacking, which could affect student preparedness for the real-world pharmacy practice experience. Hence, this study aims to estimate the reliability of virtual OSCE using a robust reliability estimation method that has already been successfully established in medical schools. Materi Generalizability Theory, Pharmacy Practice Experience Education, Reliability, Virtual Objective Structured Clinical Examination. https://www.ijper.org/spectrophotometric-estimation-of-olmesartan-medoxomil-and-metoprolol-succinate-i 2026-04-25T07:58:45.079757+00:00 Spectrophotometric Estimation of Olmesartan Medoxomil and Metoprolol Succinate in Tablet Dosage Form by Zero Order Derivative and Area Under the Curve Method 2025-12-06 10.5530/ijper.20260440 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-328.pdf Background: Olmesartan Medoxomil (OLM) and Metoprolol succinate (MET) formulations treat hypertension. The primary goal was to develop and evaluate a UV-spectrophotometric method for simultaneous estimation of OLM and MET in a combination tablet dosage form by ICH standards. Aim: The study aimed to develop a simple, swift, precise, accurate and cost-effective UV spectrophotometric method for the area under curve and zero-order method of OLM and MET in a combined tablet dosage form using distille Area under curve, Distilled water, Metoprolol succinate, Olmesartan medoxomil, Validation, Zero-order spectrophotometry. https://www.ijper.org/mechanism-of-reactive-oxygen-species-in-the-photo-cytotoxicity-and-photo-apoptot 2026-04-25T07:58:45.230957+00:00 Mechanism of Reactive Oxygen Species in the Photo-Cytotoxicity and Photo-Apoptotic Effects of Ciproquin on L929 Cells 2025-12-06 10.5530/ijper.20262410 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-350.pdf Background: Photo-unstable drugs cause undesirable clinical side effects by acting as photo-toxin in the skin and other tissue under the exposure of sunshine. Ciproquin is an antibiotic that is used to treat bacterial infections and is a member of the powerful fluoroquinolone medication class. Objectives: In this work, we evaluated photochemical characteristics of ciproquin as well as its photocytotoxicity, apoptotic, and oxidative potential on the mouse fibroblast cell line (L929) over a 24-hr Ciproquin, L929 Cells, UVB Rays, Photocytotoxicity https://www.ijper.org/synthesis-purification-and-characterization-of-some-impurities-of-propranolol 2026-04-25T07:58:44.654021+00:00 Synthesis, Purification and Characterization of Some Impurities of Propranolol 2025-12-06 10.5530/ijper.20265308 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-280.pdf Introduction: During the process of drug development, control of impurities and it should keep within the prescribed limit is very important to get high-qualified drugs. Several studies have been dedicated to synthesizing the impurities and studying the structures to support the method of purification. Propranolol is beta blocker medication preferably blocks β1 receptor, primarily used to treat high blood pressure and heart-associated chest pain. Hence synthesis and study of impurities related t Propranolol, Impurity Synthesis, 2-[(naphthalen-1-yloxy) methyl] oxirane, Ring opening, Dimerization. https://www.ijper.org/rp-hplc-estimation-of-azelnidipine-and-chlorthalidone-in-bulk-and-combined-dosag 2026-04-25T07:58:45.168392+00:00 RP-HPLC Estimation of Azelnidipine and Chlorthalidone in Bulk and Combined Dosage Forms 2025-12-06 10.5530/ijper.20265371 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-304.pdf Objectives: A simple, sensitive, robust, precise and efficient RP-HPLC approach for the simultaneous determination of Azelnidipine and Chlorthalidone in combination. Materials and Methods: As per ICH Q2 (R1) guidelines, the final chromatographic conditions were optimized with a mobile phase ratio of (30:70% v/v) in Water containing 0.1% formic acid: Methanol containing 0.1% formic acid at a flow rate of 1 mL/min, column temperature of 35ºC, injection volume of 20 μL, Interstil C18 analytical col RP-HPLC, Azelnidipine, Chlorthalidone, Forced Degradation Studies, ICH Guidelines. https://www.ijper.org/machine-learning-assisted-simultaneous-estimation-of-drugs-in-multicomponent-for 2026-04-25T07:58:44.652085+00:00 Machine Learning Assisted Simultaneous Estimation of Drugs in Multicomponent Formulations by Spectrophotometry 2025-12-06 10.5530/ijper.20265275 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-293.pdf Analysis of multi-drug formulations by spectrophotometric method is a challenging task due to mutual interference. Mathematical models reported for such analysis are applicable only where there are well separated absorption maxima of component drugs. In the present work Machine learning model has been developed for the simultaneous estimation of drugs in multi-drug pharmaceutical formulations using a custom made, comprehensive, interactive and user friendly software package, by spectrophotometry Machine learning, Spectrophotometry, Simultaneous estimation, Amlodipine, Losartan. https://www.ijper.org/protective-effects-of-petroselinum-crispum-ethanolic-extract-against-d-galactose 2026-04-25T07:58:44.962988+00:00 Protective Effects of Petroselinum crispum Ethanolic Extract Against D Galactose and Aluminum Chloride Induced Alzheimers Disease in Rats A Behavioral and Biochemical Approach 2025-12-06 10.5530/ijper.20263885 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-194.pdf Background: Alzheimer’s disease is one of the progressive neurodegenerative disorders affecting the elderly population without a clear etiology, accounting for more than 80% of dementia worldwide. We found the D-Gal and AlCl3-induced models to be the most economical, promising, and convenient among the other models for AD induction. Petroselinum crispum (parsley), with its established ethnomedicinal value mainly due to its antioxidant and neuroprotective activity, made us select it as a relevant Alzheimers disease, Ethanolic leaf extracts Petroselinum crispum, Elevated Plus Maze, Morris Water Maze, and Open Field Test. https://www.ijper.org/to-evaluate-the-safety-and-efficacy-of-autologous-nonspecific-activated-t-cells 2026-04-25T07:58:44.649564+00:00 To Evaluate the Safety and Efficacy of Autologous Nonspecific Activated T-Cells Therapy For 7,12-Dimethylbenz[A]Anthracene (DMBA) Induced Breast Cancer in Female Rats-A Supportive Care 2025-12-06 10.5530/ijper.20261253 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-252.pdf Background and objectives: Breast cancer persist a core cause of mortality in women, and current treatments like Tamoxifen often fail to address immune suppression within the tumor microenvironment. Autologous nonspecific activated T-cell therapy, either alone or combined with Tamoxifen, has shown promise in enhancing immune responses and overcoming these barriers in treating breast cancer induced by DMBA in female rats. Materials and Methods: The study involved administering DMBA to induce brea Breast Cancer, Cytokine, DMBA, Mononucleated cells, T cell therapy, Tamoxifen, Tumor Regression. https://www.ijper.org/neuroprotective-effect-of-the-isolated-fraction-from-biophytum-sensitivum-on-glu 2026-04-25T07:58:45.079828+00:00 Neuroprotective Effect of the Isolated Fraction from Biophytum sensitivum on Glutamate-Induced Neurotoxicity in HT22 Neuronal Cells 2025-12-06 10.5530/ijper.20266535 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-238.pdf Background: The present research paper elucidates to isolate specific fractions from Biophytum sensitivum and assess its ability to protect HT22 neuronal cells (immortalized mouse hippocampal neuronal cells) from glutamate induced neurotoxicity. Materials and Methods: Extraction method was employed for isolation of bioactive compounds from Biophytum sensitivum. These isolated fractions were administered to HT22 neuronal cells that had been subjected to glutamate-induced neurotoxicity. The neurop Biophytum sensitivum, Neuroprotective, Glutamate, Oxidative stress, Hippocampal cells, Antioxidant https://www.ijper.org/azilsartan-medoxomil-and-cilnidipine-spectrophotometric-determination-in-bulk-an 2026-04-25T07:58:44.932756+00:00 Azilsartan Medoxomil and Cilnidipine Spectrophotometric Determination in Bulk and Formulation: A Validated Dual Wavelength Method 2025-12-06 10.5530/ijper.20263605 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-287.pdf Introduction: If there is a rise in blood pressure then that condition is called hypertension. Azilsartan medoxomil and Cilnidipine is a new combined dosage form used in the treatment of Stage II Hypertension. Objectives: The main intention of the research is to reinforce a validated dual wavelength spectrophotometric approach for the combined evaluation of AZL and CIL in bulk and formulation. Materials and Methods: In the dual wavelength approach, for each drug two wavelengths have been chosen Azilsartan medoxomil, Cilnidipine, Dual Wavelength Method, Hypertension. https://www.ijper.org/preparation-and-pharmacological-evaluation-of-potential-hypolipidemic-activity-o 2026-04-25T08:51:09.595649+00:00 Preparation and Pharmacological Evaluation of Potential Hypolipidemic Activity of Yemeni Activated Charcoal 2025-12-06 10.5530/ijper.20266915 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-233.pdf Background: Activated charcoal is a common form of carbon that is used to filter pollutants from water and air, among numerous other uses. It is a very useful adsorbent, due to their high surface area, pore structure, and high degree of surface reactivity. Objectives: To prepare and evaluate the potential hypolipidemic effect of the Yemeni activated charcoal. Materials and Methods: The present study was carried out in vivo by examination of blood lipid components for rabbit before and after ther Activated charcoal, Cholesterol, Hypolipidemic, Yemeni, Ziziphus. https://www.ijper.org/influence-of-abcb1-polymorphisms-on-outcomes-of-breast-cancer 2026-04-25T07:58:44.932831+00:00 Influence of ABCB1 Polymorphisms on Outcomes of Breast Cancer 2025-12-06 10.5530/ijper.20261224 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1s-245.pdf Background: The importance of genotyping ABCB1 polymorphism genes in predicting the outcome of breast cancer patients receiving anthracycline and taxane-based regimens was reported. However, interethnic variations play a significant role in predicting the response to chemotherapy. Materials and Methods: This prospective study was carried out to assess the influence of ABCB1 genotypes on breast cancer response. Genotyping of ABCB1 was carried out by real-time PCR (7300 Applied Biosystems; Life Te Breast cancer, ABCB1, Clinical response, Neutropenia, Multidrug-resistant protein Efflux transporter. https://www.ijper.org/the-potential-effect-of-plant-based-antioxidants-in-breast-cancer-prevention-and 2026-04-25T07:25:22.941893+00:00 The Potential Effect of Plant Based Antioxidants in Breast Cancer Prevention and Treatment 2025-09-24 10.5530/ijper.20265693 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-54.pdf **ABSTRACT:** Breast cancer is the most common cause of death among women worldwide. According to the 2024 Cancer Statistics report, it has surpassed lung cancer as the most frequently diagnosed cancer around the world. Oxidative stress is one of the most common risk factors for breast cancer. Oxidative stress can cause mutations in breast tissue that can ultimately lead to breast cancer. Antioxidants are molecules that nullify the effects of oxidative damage and can be used as chemopreventive a Antioxidants, Breast cancer, Oxidative stress, Free radicals, Chemoprevention, Chemotherapy. https://www.ijper.org/compromised-medical-products-a-scoping-review-of-quality-safety-and-efficacy-con 2026-04-25T07:25:12.718814+00:00 Compromised Medical Products A Scoping review of Quality, Safety and Efficacy Concerns 2025-09-24 10.5530/ijper.20261930. https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-37.pdf Background: In 2011, the World Health Organization (WHO) coined the term substandard/ spurious/falsely labelled/falsified/counterfeit (SSFFC) to describe medical products that compromise quality, safety, and efficacy. Despite its broad usage, the term 'SSFFC' was not sufficient to differentiate between the various categories of illicit medicines, each of which requires distinct regulatory responses. In 2017, the WHO took a significant step by rationalizing the terminology, promoting transparency Substandard, Spurious, Falsified, Falsely labelled, Counterfeit. https://www.ijper.org/molecular-docking-synthesis-and-determination-of-anticancer-potential-of-novel-p 2026-04-25T09:17:08.828304+00:00 Molecular Docking, Synthesis and Determination of Anticancer Potential of Novel Pyrimidine Derivatives: In vitro and in silico Characterization 2025-09-24 10.5530/ijper.20260733 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-361.pdf Background: Lung and colon carcinoma are leading causes of mortality among all cancers and cases are increasing drastically. Chemotherapy plays vital role in the treatment of carcinoma and a new series of pyrimidine heterocycles attached to an azetidone has strong anti-cancer potential. Aim: Aim of current research work is to investigate the affinity of pyrimidine derivatives with the CDK4 protein using molecular docking. Materials and Methods: Antitumor activity of synthesized compounds was che Anticancer, Apoptosis, CDK4, Molecular docking, Pyrimidine https://www.ijper.org/monoterpene-pinene-alleviates-diabetic-retinopathy-in-rodent-model-via-attenuati 2026-04-25T09:17:10.28896+00:00 Monoterpene Α-Pinene Alleviates Diabetic Retinopathy in Rodent Model via Attenuating Hyperglycemia Induced VEGF Signaling 2025-09-24 10.5530/ijper.20261413 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-312.pdf Background: Diabetic Retinopathy (DR) has emerged as a significant global health issue that requires urgent and collaborative action to tackle. As the leading causes of preventable blindness, DR predominantly impacts adults in their working years, posing a significant threat to both individual quality of life and global economic productivity. This research work was aimed at assessing the potency of α-Pinene; a miracle compound on ameliorating hyperglycemia induced diabetic retinopathy in rodent Anti-VEGF drug, Diabetic induced retinal disorder, Inflammation, Oxidative stress, Phytocompound, α-Pinene https://www.ijper.org/a-review-of-game-based-learning-in-higher-education-exploring-escape-room-method 2026-04-25T07:25:02.242361+00:00 A Review of Game-Based Learning in Higher Education: Exploring Escape-Room Methodologies in Educational Settings 2025-09-24 10.5530/ijper.20261516 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-28.pdf **ABSTRACT:** Conventional teaching approaches that lack interactive techniques may hinder the effectiveness of knowledge acquisition and student engagement. Innovative teaching approaches are essential to engage with tech-savvy Generation Z students. Game-based concepts, particularly educational escape rooms are gaining attention as effective teaching tools in higher education. This review explores the development and implications of educational escape rooms in terms of student knowledge, engag Active Learning, Educational Games, Game-Based Learning, Higher Education. https://www.ijper.org/revolutionizing-dental-practice-a-review-of-innovations-in-dental-materials 2026-04-25T07:24:42.705522+00:00 Revolutionizing Dental Practice: A Review of Innovations in Dental Materials 2025-09-24 10.5530/ijper.20261637 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-1.pdf **ABSTRACT:** Dental materials are essential in modern dentistry, facilitating the diagnosis, treatment, and prevention of oral diseases. They are utilized in restorative, prosthetic, preventive, endodontic, and orthodontic procedures, with selection guided by mechanical, biological, chemical, and aesthetic properties. Innovations in nanotechnology, bioactive compounds, and digital dentistry have greatly enhanced both functional and aesthetic outcomes. This review explores the classification, pr Adhesive dentistry, Bioactive materials, Biocompatibility, CAD/CAM technology, Dental materials, Nanotechnology, Restorative dentistry. https://www.ijper.org/neuroprotective-effect-of-inula-racemosa-on-chronic-stress-aluminum-chloride-ind 2026-04-25T09:17:08.811894+00:00 Neuroprotective Effect of Inula racemosa on Chronic Stress-Aluminum Chloride Induced Memory Deficits 2025-09-24 10.5530/ijper.20261730 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-258.pdf Introduction: Alzheimer's Disease (AD) is characterized by cognitive impairment resulting from the accumulation of amyloid beta and tau plaques, reduced Brain-Derived Neurotrophic Factor (BDNF) expression, neuronal death, and brain inflammation. Chronic stress accelerates aging, while aluminum, a neurotoxin, is implicated in AD pathology. Objectives: This study aimed to assess the potential beneficial effects of Inula racemosa on cognitive deficits induced by chronic stress and aluminum chloride Aluminum Chloride, chronic Stress, Cognitive Impairment, Amyloid Beta, BDNF, Inula racemosa. https://www.ijper.org/antioxidant-and-anti-inflammatory-efficacy-of-dipsacoside-b-in-ameliorating-myoc 2026-04-25T09:17:10.528037+00:00 Antioxidant and Anti-Inflammatory Efficacy of Dipsacoside B in Ameliorating Myocardial Infarction in an in vivo Model 2025-09-24 10.5530/ijper.20262103 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-294.pdf Background: Myocardial Infarction (MI) is a severe coronary ailment associated with a great risk of mortality, often contributing to sudden cardiac death. Cardiovascular diseases account for approximately 32% of global deaths, with MI representing 85% of these cases, necessitating immediate and extensive medical intervention. Objectives: In this study, we investigated the therapeutic efficacy of the triterpenoid saponin dipsacoside B in alleviating myocardial infarction. Materials and Methods: M Myocardial infarction, ISO MI in vivo model, Phytochemical, Dipsacoside, Antioxidant, Anti-inflammatory agent https://www.ijper.org/bilobetin-shows-immunomodulatory-and-chemopreventive-activities-in-benzoapyrene 2026-04-25T09:17:09.776569+00:00 Bilobetin Shows Immunomodulatory and Chemopreventive Activities in Benzo(a)pyrene-Induced Lung Cancer in Mice Model 2025-09-24 10.5530/ijper.20262240 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-421.pdf Background: Lung cancer, a malignancy resulting from the uncontrolled growth of cells in pulmonary tissues, remains to be a primary cause of cancer-associated deaths worldwide, requiring a thorough understanding of its complex pathophysiology to develop effective treatment techniques. Objectives: The present work was aimed at analyzing the anticancer properties of the bilobetin against benzo(a)pyrene (B(a)P)-induced lung cancer in mice. Materials and Methods: Lung cancer was induced in mice with Cytochrome P450, Immunoglobulins, Glutathione-S-transferase, Bilobetin, Lung, cancer https://www.ijper.org/stability-indicating-method-development-and-validation-by-analytical-quality-by 2026-04-25T09:17:11.536278+00:00 Stability Indicating Method Development and Validation by Analytical Quality by Design Approach Using UV-Spectrophotometer for Alfuzosin Hydrochloride and Tadalafil in Bulk and Marketed Formulation 2025-09-24 10.5530/ijper.20261965 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-442.pdf **Introduction::** The combination of Alfuzosin and Tadalafil is used to treat both erectile dysfunction and lower urinary tract symptoms. The purpose of this work is to develop and evaluate a UV-spectrophotometric method for simultaneously estimating Alfuzosin hydrochloride and Tadalafil in bulk and marketed formulation, using a Analytical Quality by Design methodology to assure robustness and reliability. **Objectives::** The current work aims to develop a simple, precise and cost-effective U Alfuzosin hydrochloride, Tadalafil, UV-spectrophotometric, ICH guidelines, AQbD. https://www.ijper.org/effect-of-carvacrol-in-attenuating-the-tnf-induced-sarcopenia 2026-04-25T09:17:11.540812+00:00 Effect of Carvacrol in Attenuating the TNF-α Induced Sarcopenia 2025-09-24 10.5530/ijper.20262945 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-209.pdf **Background::** Sarcopenia is a condition characterized by muscle loss, which is accompanied by inflammation, oxidative stress, and mitochondrial dysfunction. The current treatment of sarcopenia is insufficient in handling the issues it faces, which may need alternative therapy, especially from natural sources. Carvacrol is a natural compound that has shown antioxidant and anti-inflammatory properties previously, making it an ideal choice for evaluating its potential in sarcopenia treatment. * Sarcopenia, Carvacrol, Oxidative Stress, Mitochondria, TNF-alpha. https://www.ijper.org/in-vitro-anti-oxidant-antimicrobial-in-silico-molecular-docking-analysis-and-phy 2026-04-25T09:17:09.114022+00:00 In vitro Anti-oxidant, Antimicrobial, in silico Molecular Docking Analysis, and Phylogenetic Analysis of Anoectochilus elatus 2025-09-24 10.5530/ijper.20262104 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-283.pdf **Background::** Medicinal plants have long been valued for their therapeutic properties, offering a rich reservoir of bioactive compounds. Across millennia, diverse cultures worldwide have developed intricate systems of traditional medicine, utilizing plant-based remedies to treat a wide range of ailments. **Objectives::** This study investigates the in vitro antioxidant and antimicrobial activities, along with in silico analyses, of the roots of Anoectochilus elatus. **Materials andMethods:: Pathogens, Antioxidant, Anoectochilus elatus, In silico analysis, Maturase K. https://www.ijper.org/in-vitro-and-in-silico-analysis-alnustone-induced-anticancer-effects-in-human-ga 2026-04-25T09:17:11.325378+00:00 In vitro and in silico Analysis Alnustone Induced Anticancer Effects in Human Gastric Cancer 2025-09-24 10.5530/ijper.20251185 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-374.pdf **Background::** A growing number of people are at risk for gastrointestinal disorders due to dietary modifications and excessive consumption of processed food. Gastric Cancer (GC) ranks fifth in terms of frequency of diagnosis and is the third most common cause of cancer-related deaths worldwide. **Objectives::** The current work demonstrated the anti-cancer potential of Alnustone against stomach cancer in AGS cell lines. **Materials and Methods::** The cell viability study was performed to d ADMET, Alnustone, Caspase, Gastric cancer, Molecular docking. https://www.ijper.org/anti-nociceptive-and-anti-inflammatory-effects-of-withanone-in-various-nocicepti 2026-04-25T09:17:10.946559+00:00 Anti-nociceptive and Anti-inflammatory Effects of Withanone in Various Nociception and Inflammation-Induced Murine Model 2025-09-24 10.5530/ijper.20261166 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-247.pdf **Background::** Pain is an unpleasant sensation that may result from severe or harmful stimuli. It serves as an indication that there may be a problem within the body and it can aid in ensuring the protection. Pain is a ubiquitous experience, with a significant prevalence worldwide. Pain can arise from various sources, including injury, disease, or even emotional trauma and its manifestation can range from acute to chronic. **Objectives::** The current work has focused at exploring the anti-in Carrageenan, Cytokines, Formalin, Nociception, Tail flick test, Withanone. https://www.ijper.org/osthenol-shows-cardioprotective-activity-against-isoproterenol-induced-myocardia 2026-04-25T09:17:11.168623+00:00 Osthenol Shows Cardioprotective Activity Against Isoproterenol-Induced Myocardial Infarction in Rats via Inhibiting Oxidative Stress and Inflammation 2025-09-24 10.5530/ijper.20261966 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-191.pdf Background: Myocardial Infarction (MI) is a devastating cardiovascular complication that develops when blood flow to a region of the myocardium is obstructed, resulting in cardiomyocyte necrosis and loss of contractile function. Objectives: This study was intended to assess the cardioprotective activity of the osthenol against Isoproterenol (ISO)-induced MI in rat model. Materials and Methods: The Sprague-Dawley rats were subjected to ISO administration to develop MI and were pre- and co-treated Creatine kinase-MB, Myocardial infarction, Osthenol, Interleukin-6, Heart rate https://www.ijper.org/a-validated-hptlc-method-for-simultaneous-estimation-of-berberine-and-trigonelli 2026-04-25T09:17:11.071818+00:00 A Validated HPTLC Method for Simultaneous Estimation of Berberine and Trigonelline in Polyherbal Mixture A Tool for Quality Control and Standardization 2025-09-24 10.5530/ijper.20260726 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-431.pdf **Introduction::** Berberis aristata and Trigonella foenumgrecum have been used in traditional medicine for various purposes due to their diverse therapeutic benefits such as anti-inflammatory, antidiabetic, antihypertensive and digestive properties. Berberis aristata and Trigonella foenumgrecum consists of bioactive markers Berberine and Trigonelline respectively. **Aim::** This study aimed to develop a simple, rapid reliable and robust HPTLC method for the simultaneous quantification of bioma Berberine, Trigonelline, Polyherbal mixture, HPTLC, Analytical method validation, Quality control. https://www.ijper.org/prevalence-of-depression-in-the-diabetic-population-and-its-influence-on-glycaem 2026-04-25T09:17:11.490203+00:00 Prevalence of Depression in the Diabetic Population and its Influence on Glycaemic Profile: A Prospective Interventional Study 2025-09-24 10.5530/ijper.20261640 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-452.pdf Objectives: The study aims to determine the prevalence of depression in the diabetic population and its influence on glycaemic profile. Materials and Methods: A prospective interventional study was conducted at Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India. This study included 300 patients diagnosed with Type 2 Diabetes (T2D) and exhibiting depression with a PHQ-9 score >5. Depression levels were assessed before and after the intervention using validated measures. A chi-s Diabetes, Depression, Glycaemic profile, Intervention https://www.ijper.org/evaluation-of-polyherbal-preparation-containing-aegle-marmelos-and-saraca-asoca 2026-04-25T09:17:10.833365+00:00 Evaluation of Polyherbal Preparation Containing Aegle marmelos and Saraca asoca Plants for Screening of Urolithiasis Disease 2025-09-24 10.5530/ijper.20261403 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-183.pdf Aim: To evaluate the efficacy of a polyherbal formulation in alleviating urolithiasis induced by ethylene glycol in a rat model and to assess its effects on biochemical and histopathological parameters. Background: Urolithiasis is a condition characterized by the formation of stones in the urinary tract, often leading to significant health issues. This study investigates the anti-urolithiatic effects of a polyherbal formulation containing Aegle marmelos and Saraca asoca in albino Wistar rats. To Urolihiasis, Urinary parameters, Serum parameters, Ethylene glycol, Aegle marmeos, Saraca asoca https://www.ijper.org/morpho-genetic-variability-in-phytochemical-composition-and-essential-oils-of-th 2026-04-25T09:17:08.773974+00:00 Morpho-Genetic Variability in Phytochemical Composition and Essential Oils of Three Common Lavandula Species Cultivated in Van, Türkiye 2025-09-24 10.5530/ijper.20261158 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-305.pdf **Background::** Lavandula sp. is a valuable plant species as ornamental plant with beautiful inflorescence and aromatic plant with high yield of essential oil. Lavender is mostly produced in Europe, the Middle East, Asia, Northern Africa, France and Bulgaria. Most varieties of lavender are known for their sedative properties and have historically been used to treat diabetes, depression and headaches. Chemical composition and the existence of phenolic compounds may be related to these biological Antioxidant Activity, Essential Oils, Lavandula, Mineral Content, Phytochemicals. https://www.ijper.org/design-and-characterization-of-camptothecin-loaded-colloidosomes-for-the-effecti 2026-04-25T09:17:11.522397+00:00 Design and Characterization of Camptothecin Loaded Colloidosomes for the Effective Treatment of Lung Cancer 2025-09-24 10.5530/ijper.20260528 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-150.pdf **Background::** Among the various cancers, lung cancer is the second leading cause of mortality after the breast carcinoma. Camptothecin (CPT) has broad spectrum anticancer potential used in the effective management of cancer including lung cancer. However, the therapeutic applications of CPT in the clinics are restricted due to its poor water solubility, low bioavailability and severe toxicities. Therefore, current research work was aimed to develop, optimize and characterize colloidosomes for Apoptosis, Camptothecin, Colloidosomes, Cytotoxicity, Lung cancer, Optimization. https://www.ijper.org/targeting-alpha-amylase-discovering-novel-inhibitors-through-e-pharmacophore-mod 2026-04-25T09:17:11.184261+00:00 Targeting Alpha-Amylase: Discovering Novel Inhibitors through E-Pharmacophore Modeling and in vitro studies 2025-09-24 10.5530/ijper.20261204 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-383.pdf Background: Diabetes mellitus is a metabolic disorder affecting millions worldwide, with prevalence continuing to rise globally. A major therapeutic challenge is controlling postprandial blood glucose spikes that contribute to chronic hyperglycemia and associated vascular complications in diabetes. Pancreatic alpha-amylase is a key enzyme responsible for digesting dietary carbohydrates into absorbable sugars, making it an attractive target for managing postprandial hyperglycemia. While inhibitor Acarbose, Alpha-Amylase, Database Screening, Diabetes mellitus, E-pharmacophore, Voglibose https://www.ijper.org/formulation-development-and-evaluation-of-self-microemulsifying-drug-delivery-sy 2026-04-25T07:30:59.807112+00:00 Formulation Development and Evaluation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Azelnidipine for Hypertension 2025-09-24 10.5530/ijper.20266497 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-114.pdf **Introduction/Objectives::** Azelnidipine is a novel calcium channel blocker usually recommended for the management of an upsurge in blood pressure. The beneficial activity is circumvented because of extreme lipophilicity (Log P: 5.14). The present investigation is dedicated to the expansion of solubility and dissolution of Azelnidipine by self-microemulsifying drug delivery. **Materials and Methods::** The estimation of solubility of Azelnidipine was checked in several oils, surfactants, and SMEDDS, Azelnidipine, Hypertension, Microemulsion, Ternary Phase diagram. https://www.ijper.org/formulation-development-and-evaluation-of-transferosomal-gel-using-trifarotene 2026-04-25T07:30:41.646714+00:00 Formulation Development and Evaluation of Transferosomal Gel Using Trifarotene 2025-09-24 10.5530/ijper.20261010 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-96.pdf Background: Trifarotene (TFT), a retinoid commonly used for acne treatment, suffers from poor water solubility, limiting its effectiveness and increasing the risk of side effects. Enhancing its bioavailability and providing sustained drug release could improve therapeutic outcomes while reducing side effects. Objectives: The study aimed to develop and optimize a transferosomal gel formulation of Trifarotene to enhance drug availability at the target site, achieve sustained release, and minimize Acne, Thin lipid film hydration, Transferosomal gel, Transferosome, Trifarotene. https://www.ijper.org/anticancer-effects-of-silver-nanoparticles-synthesized-from-eupatorium-adenophor 2026-04-25T09:17:10.565755+00:00 Anticancer Effects of Silver Nanoparticles Synthesized from Eupatorium adenophorum Extract in Animal Model: Impact on Tumor Growth, Apoptotic Markers and Organ Biomarkers 2025-09-24 10.5530/ijper.20261036 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-172.pdf Background: Silver Nanoparticles (AgNPs) synthesized from plant extracts have shown significant anticancer potential. This study explores the efficacy of AgNPs prepared from the methanolic extract of Eupatorium adenophorum leaves in treating breast cancer in mice, focusing on their effects on tumor size, weight loss, biochemical markers, and apoptosis-related gene expression. Materials and Methods: AgNPs were synthesized and characterized for their size, morphology, and stability. Female BALB/c Cancer, Eupatorium adenophorum, MDA MB 231, Murine, Silver nanoparticles, Tumor. https://www.ijper.org/chrysin-ameliorates-mycoplasma-pneumonia-induced-pneumonia-in-mice-by-down-regul 2026-04-25T09:17:09.187739+00:00 Chrysin Ameliorates Mycoplasma pneumonia Induced Pneumonia in Mice by Down-Regulating Inflammatory Response 2025-09-24 10.5530/ijper.20261592 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-163.pdf Background: Mycoplasma pneumonia, a major respiratory infection characterized by inflammation of the lungs, poses a substantial global health concern, particularly among vulnerable populations such as the elderly, immunocompromised individuals and young children. Objectives: The current study has focused on exploring the attenuation of Mycoplasma pneumoniae (Mp)-induced pneumonia by chrysin in rodent model. Materials and Methods: BALB/c mice were administered 1×108 (50 μL) of Mp via nasal drops Chrysin, Cytokines, Mycoplasma pneumonia, Azithromycin, Inflammatory cells https://www.ijper.org/3d-bioprinting-potential-technology-for-drug-delivery 2026-04-25T07:24:53.036835+00:00 3D Bioprinting Potential Technology for Drug Delivery 2025-09-24 10.5530/ijper.20261646 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-14.pdf **ABSTRACT:** The advent of three-Dimensional (3D) bioprinting offers transformative opportunities in tissue engineering, enabling the precise fabrication of functional tissues and organs for medical and research applications. This study aims to explore the scientific advancements in 3D bioprinting techniques and bioinks while evaluating their potential to overcome current biomedical challenges. Using a comprehensive review of cutting-edge bioprinting methods, this work analyses the integration 3D bioprinting, Regenerative medicine, Personalized medicine, Bioinks. https://www.ijper.org/ppar-and-glut-4-mediated-insulin-sensitizing-action-of-paspalum-scrobiculatum-gr 2026-04-25T09:17:10.943287+00:00 PPAR-γ and GLUT-4 Mediated Insulin Sensitizing Action of Paspalum scrobiculatum Grains; An In vivo and In silico Study towards Validating it as a Long-Term Therapy for Type 2 Diabetes 2025-09-24 10.5530/ijper.20261128 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-322.pdf **Purpose::** Insulin Resistance (IR) usually results from a decline in levels of critical signalling proteins, their functional modifications, or both. Food and drinks rich in fat, energy and/or sugars increases the risk of obesity, promoting systemic IR and Type 2 Diabetes (T2D). Therapeutic approaches using natural compounds which promote and upregulate Glucose Transporter-4 (GLUT-4) and/or Peroxisome Proliferator Activated Receptors-y (PPAR-y), or increase adiponectin productions are advocat Glucose transporter-4, High fructose High Fat feed, Insulin resistance, Paspalum scrobiculatum, PPAR-γ, Type 2 Diabetes. https://www.ijper.org/exosomal-mir-34b-5p-from-bone-marrow-mesenchymal-stem-cells-attenuates-spinal-co 2026-04-25T09:17:10.930002+00:00 Exosomal miR-34b-5p from Bone Marrow Mesenchymal Stem Cells Attenuates Spinal Cord Injury via MAPK/PI3K/ AKT Pathway Modulation 2025-09-24 10.5530/ijper.20262022 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-336.pdf Introduction: Bone Marrow Mesenchymal Stem Cells (BMMSCs) promote Spinal Cord Injury (SCI) recovery via exosomes containing bioactive molecules. This study examined the role and mechanisms of BMMSC-derived exosomes overexpressing microRNA-34b-5p (miR-34b-5p) in neuronal repair after SCI. Materials and Methods: BMMSCs were isolated from four 4-week- old Sprague-Dawley rats and introduced to miR-34b-5p mimics or Negative Controls (NC), after which exosomes were extracted and characterized. Twenty- Bone marrow mesenchymal stem cells, Exosome, MiR-34b-5p, Spinal cord injury, MAPK/PI3K/Akt pathway https://www.ijper.org/integrating-diversified-graphical-thinking-mode-into-the-teaching-practice-of-in 2026-04-25T07:25:32.927514+00:00 Integrating Diversified Graphical Thinking Mode into the Teaching Practice of Inorganic Chemistry 2025-09-24 10.5530/ijper.20256458 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-63.pdf **Background::** Inorganic chemistry holds significant importance in pharmacy major as it serves as the foundation for subsequent professional courses. However, students exhibit varying learning conditions during the teaching process, with some struggling due to weak knowledge of chemistry. **Objectives::** To enhance the quality of teaching and learning outcomes, foster logical thinking skills and independent learning abilities among students and further promote the exploration and implementat Graphic thinking mode, Inorganic chemistry, Teaching strategy, Chemical teaching, Higher education. https://www.ijper.org/formulation-optimization-and-in-vitro-evaluation-of-ibuprofen-loaded-cubosomal-n 2026-04-25T07:31:16.953565+00:00 Formulation, Optimization and in vitro Evaluation of Ibuprofen-Loaded Cubosomal Nano-Formulation for Effective Topical Delivery 2025-09-24 10.5530/ijper.20264232 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-132.pdf Objectives: This research aims to formulate and assess an Ibuprofen-loaded cubosomal gel that would improve the drug's skin absorption and minimize its oral adverse effects. Hence, clinically relevant drug concentration reaches the skin surface for effective transdermal delivery. Materials and Methods: Ibuprofen-loaded Cubosomal Nanoformulation was prepared using a top-down approach by varying Glyceryl Mono-Oleate (GMO) and Polaxomer 407 (PF 127). The prepared cubosomal nanoformulations were sub Cubosomes, Ibuprofen, Nano-formulation, Transdermal drug delivery. https://www.ijper.org/solid-lipid-nanoparticles-of-resveratrol-formulation-characterization-and-in-vit 2026-04-25T09:17:09.248265+00:00 Solid Lipid Nanoparticles of Resveratrol: Formulation, Characterization and In vitro Anti-Inflammatory Studies 2025-09-24 10.5530/ijper.20261895 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-270.pdf Aim: An oral administration formulation including resveratrol and solid lipid nanoparticles is the focus of this investigation. Materials and Methods: The resveratrol SLN was prepared utilizing oleic acid as the surfactant and hydrogenated castor oil as the lipid matrix by the high-pressure homogenization process. The FTIR and DSC techniques were used to conduct the chemical as well as physical drug interaction. Using scanning electron microscopy, the physicochemical properties of SLN were exami Resveratrol, Solid Lipid Nanoparticles, Anti-Inflammatory Activity, Sustained Release, Stability https://www.ijper.org/protective-effects-of-cassia-fistula-linn-on-reproductive-organs-weight-and-tiss 2026-04-25T09:17:11.250449+00:00 Protective Effects of Cassia fistula Linn. On Reproductive Organs Weight and Tissue Biochemical Markers in Streptozotocin-Induced Diabetic Male Rats 2025-09-24 10.5530/ijper.20261582 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-200.pdf **Objectives::** This study aims to evaluate the impact of hydroethanolic extract from Cassia fistula pods on reproductive organs weight and biochemical markers within reproductive tissues in experimental diabetic rats. **Materials and Methods::** Type 1 diabetes mellitus was induced in male Wistar rats by administering a single intraperitoneal injection of streptozotocin. Diabetic rats were then given oral doses of Cassia fistula Pods Extract (CFPE) at 100, 250, and 500 mg/kg BW per day over a Cassia fistula, Glibenclamide, Reproductive organs weight, Streptozotocin, Tissue biochemistry. https://www.ijper.org/optimizing-ultrasonic-extraction-of-antioxidants-and-polyphenols-in-five-indigen 2026-04-25T07:30:31.905135+00:00 Optimizing Ultrasonic Extraction of Antioxidants and Polyphenols in Five Indigenous Remedial Plants Using Box-Behnken Design Combined with Response Surface Methodology 2025-09-24 10.5530/ijper.20260925 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-83.pdf **Aim/Background::** This study aimed to optimize the ultrasonic extraction of antioxidants and polyphenols from five indigenous medicinal plants Cassia auriculata, Celastrus paniculatus, Moringa concanensis, Murraya koenigii, and Alternanthera sessilis using Box-Behnken Design (BBD) and Response Surface Methodology (RSM). The goal was to enhance the extraction efficiency of these bioactive compounds, which are crucial for mitigating oxidative stress and preventing chronic diseases. **Materials Antioxidant, Box-Behnken Design, Optimization, Polyphenols, Ultra-sonication. https://www.ijper.org/effect-of-theobroma-cocoa-extract-on-olanzapine-induced-metabolic-syndrome-in-ra 2026-04-25T09:17:11.490306+00:00 Effect of Theobroma cocoa Extract on Olanzapine-Induced Metabolic Syndrome in Rats 2025-09-24 10.5530/ijper.20261703 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-237.pdf **Objectives::** This study examined the effects of Theobroma cocoa hydro-alcoholic Extract (TCE) on the metabolic syndrome that rats developed because of olanzapine. **Materials and Methods::** Dry cocoa powder was macerated in 80% ethanol for seven days to create the TCE. Filtration and concentration were then carried out under lower pressure. Rats (n=6) were divided into five groups. Three dosages of TCE (100, 200, and 400 mg/kg) were administered orally for 21 days along with olanzapine (2 Olanzepine, Locomotor activity, Lipid metabolism, Weight gain, Theobroma cocoa. https://www.ijper.org/deciphering-key-protein-targets-hub-gene-networks-signaling-pathways-and-in-sili 2026-04-25T09:17:09.468463+00:00 Deciphering Key Protein Targets, Hub Gene Networks, Signaling Pathways and in silico Docking Studies of Artemisinin in Human Lung Carcinoma 2025-09-24 10.5530/ijper.20261248 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-393.pdf Background: Artemisinin has been reported to exert potent anticancer effects in diverse cancers, but its mode of anticancer action is not fully understood. Objectives: This study involved network pharmacology, bioinformatics, in silico molecular docking and dynamics along with experimental validation to demonstrate the anticancer activity as well as detailed mode of action of artemisinin in lung cancer. Materials and Methods: SwissADME and Protox-II analyzed physicochemical properties and toxici Apoptosis, Artemisinin, Gene-ontology, Immune infiltration, Lung cancer, Natural, products, Network pharmacology https://www.ijper.org/preparation-and-characterization-of-eudragit-l100s100-coated-zafirlukast-pellets 2026-04-25T07:30:51.013177+00:00 Preparation and Characterization of Eudragit L100/S100 Coated Zafirlukast Pellets for Chronotherapy 2025-09-24 10.5530/ijper.20261013 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-106.pdf **Background::** The initial goal of the current research investigation was to design, develop oral formulation of Pulsatile Drug Delivery Systems (PDDS) for Zafirlukast with aim of treatment for asthma. Delivery system was designed as Pellets type of system with Immediate and extended release of drug occurs at after the lag time period. In chronic asthma condition patients suffered during the early morning hours (04.00 AM to 06.00 AM) so immediate release dosage forms are not suitable but the m Enteric coating, Extrusion, Lag time, Pulsatile, Spheronization. https://www.ijper.org/optimization-of-pitavastatin-calcium-and-micronized-fenofibrate-bi-layer-tablets 2026-04-25T07:31:08.213988+00:00 Optimization of Pitavastatin Calcium and Micronized Fenofibrate Bi-layer Tablets Using Quality by Design 2025-09-24 10.5530/ijper.20260939 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-124.pdf **Background and Purpose::** This study aimed to develop bilayer tablets containing pitavastatin calcium and micronized fenofibrate. **Materials and Methods::** For optimization of manufacturing based on preliminary formulation research, a 24+3 full factorial Design of Experiments (DoE) study was conducted to elucidate the effects of four factors (Ludipress, crospovidone, Polyethylene Glycol (PEG) 6000, main compression) influencing tablet Critical Quality Attributes (CQAs) such as hardness, fr Design of experiment, Micronized fenofibrate, Pita vastatin calcium, Quality by design. https://www.ijper.org/atractylenolide-iii-relieves-diphenoxylate-induced-constipation-via-gut-microbio 2026-04-25T09:17:11.450522+00:00 Atractylenolide III Relieves Diphenoxylate-Induced Constipation via Gut Microbiota and Bile Acid Pathway Modulation 2025-09-24 10.5530/ijper.20251336 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-348.pdf **Aim/Background::** An imbalance of intestinal flora and its fermentation products can disrupt intestinal peristalsis and lead to constipation. This study aimed to investigate how Atractylenolide III (ATL-III) may enhance constipation treatment by regulating the gut microbiota-bile acid metabolism pathway. **Materials and Methods::** In this study, an experimental mouse model of constipation was established and intestinal motility, colonic neurotransmitter release, and bile acid metabolism wer Atractylenolide III (ATL-III), Constipation, Intestinal barrier, Gut microbiota, Bile acids (BAs). https://www.ijper.org/investigaton-of-the-protective-effect-of-hydrogen-sulphide-donor-sodium-hydrosul 2026-04-25T09:17:11.448961+00:00 Investigatıon of the Protective Effect of Hydrogen Sulphide Donor Sodium Hydrosulphide and Sulfurized Apricot on Experimental Acute Kidney Injury Induced by Cisplatin in Rats 2025-09-24 10.5530/ijper.20261390 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-410.pdf Background: In the present study, we aimed to investigate the protective effect of Hydrogen sulfide (H2S) donor Sodium Hydrosulphide (NaHS) and Sulfurized Apricot (SA) on experimental acute kidney injury induced by cisplatin in rats. Materials and Methods: Four groups of Wistar albino rats were formed with 10 rats in each group: Control group, Cisplatin group, Cisplatin+SA group, and Cisplatin+NaHS group. The activities of Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPx) Acute kidney injury, Hydrogen sulfide, Sulfurized apricot, Cisplatin https://www.ijper.org/formulation-development-and-evaluation-of-atorvastatin-soy-lecithin-solid-disper 2026-04-25T07:25:45.288514+00:00 Formulation Development and Evaluation of Atorvastatin Soy Lecithin Solid Dispersion A Promising Approach for Solubility Enhancement 2025-09-24 10.5530/ijper.20262703 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-73.pdf **Background::** Hyperlipidaemia remains a significant contributor to cardiovascular disorders, with statins being the primary therapeutic agents for its management. However, the clinical efficacy of these drugs, particularly atorvastatin, a statin with an extended plasma half-life of 18-24 hr is hindered by poor aqueous solubility, which limits bioavailability. This study aimed to address this limitation by enhancing the solubility and dissolution profile of atorvastatin through advanced formul Solid dispersion, Atorvastatin, Soy Lecithin, Solubility Enhancement, Orodispersible Tablets. https://www.ijper.org/development-and-characterization-of-catechin-loaded-self-nanoemulsifying-drug-de 2026-04-25T09:17:09.229936+00:00 Development and Characterization of Catechin-Loaded Self-Nanoemulsifying Drug Delivery System: Pharmacokinetics, Toxicity Assessment, and in vivo Anti-Ulcer Activity Evaluation 2025-09-24 10.5530/ijper.20261584 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-60-1-219.pdf Purpose: This research aimed to prepare catechin-loaded SNEDDS that would improve the oral therapeutic efficacy of catechin. Materials and Methods: Catechin-SNEDDS was prepared and characterized using emulsification time, percent transmittance, thermodynamic stability, droplet size, polydispersity index, and morphological characterization. Tween 80 (surfactant), propylene glycol (co-surfactant), and olive oil (oil phase) with the highest solubility of catechin were used to prepare catechin-SNEDD Catechin, SNEDDs, Bioavailability, Anti-ulcer, Anti-oxidant. https://www.ijper.org/anti-inflammatory-and-anti-allergic-effects-of-salvigenin-in-an-ovalbumin-induce 2026-04-25T06:52:31.749167+00:00 Anti-inflammatory and Anti-allergic Effects of Salvigenin in an Ovalbumin-Induced Allergic Rhinitis in Mice 2025-07-28 10.5530/ijper.20251122 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1366.pdf Background: Allergic Rhinitis (AR) is a prevalent inflammatory disorder of the nasal mucosa, often triggered by an IgE-mediated immune reaction to allergens. The underlying cause of AR can be attributed to the genetic predisposition and environmental causes that trigger an aberrant immune response. Objectives: The present work was performed to understand the salutary roles of salvigenin against allergen-initiated AR in mice. Materials and Methods: AR was initiated in BALB/c mice by intraperitone Allergic diseases, Histamine, Inflammation, Malondiadehyde, Salvigenin https://www.ijper.org/analytical-method-development-and-validation-by-rp-hplc-and-uv-spectrophotometri 2026-04-25T06:59:16.257427+00:00 Analytical Method Development and Validation by RP-HPLC and UV Spectrophotometric for Estimation of Daprodustat in Bulk and Pharmaceutical Dosage Form 2025-07-28 10.5530/ijper.20250016 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1613.pdf Objectives: This research aimed to systematically boost the development and validation of newly devised, precise, reproducible and accurate UV and Reverse Phase High Performance Liquid Chromatography (RP-HPLC) methods for Daprodustat. Materials and Methods: UV-visible spectrophotometer (Jasco V-730) was used for the analysis and the absorbance was measured across the UV and visible spectra. Measurements were taken at 265 nm, a UV wavelength. Samples were prepared in methanol and selected for com Daprodustat, RP-HPLC, UV-Spectroscopy, Validation, Analytical Method https://www.ijper.org/the-construction-and-application-of-process-evaluation-in-the-grade-evaluation-o 2026-04-25T06:47:49.316305+00:00 The Construction and Application of Process Evaluation in the Grade Evaluation of Pharmacology Experiment 2025-07-28 10.5530/ijper.20257182 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1238.pdf Pharmacology laboratory teaching includes basic animal handling, basic experiments, integrated experiments, designed experiments and scenario-based discussions between doctors and patients. The problems in the evaluation of pharmacology laboratory performance include the predominance of summative evaluation, a single index for laboratory performance assessment and weak teaching feedback. This paper aims to discuss the practice and significance of adding process evaluation to the evaluation syste Grade Evaluation of Experiment, Pharmacology Experiment, Process Evaluation https://www.ijper.org/in-silico-and-in-vitro-characterization-of-potent-cdk2-inhibitors-as-probable-ca 2026-04-25T06:58:37.713304+00:00 In silico and In vitro Characterization of Potent CDK2 Inhibitors as Probable Cancer Therapeutics 2025-07-28 10.5530/ijper.20251532 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1582.pdf Background: Cyclin-Dependent Kinases (CDKs) are a family of serine/threonine protein kinases that play pivotal roles in the regulation of the cell cycle and various cellular processes. Among them, CDK2 is a crucial regulator of the G1/S phase transition and is crucial for the proper progression of the cell cycle. Dysregulation of CDK2 activity is frequently observed in various types of cancer, making it an attractive therapeutic target. Dinaciclib, a potent CDK2 inhibitor, has demonstrated clini CDK2, Dinaciclib, Molecular Docking, Molecular Dynamics, ADMET, PubChem and, Enzymatic assay https://www.ijper.org/harnessing-saussurea-lappa-for-anti-leishmanial-anti-toxoplasmic-and-anti-bacter 2026-04-25T06:53:45.465002+00:00 Harnessing Saussurea lappa for Anti-leishmanial, Anti-toxoplasmic, and Anti-bacterial Activity: Molecular and Computational Insights 2025-07-28 10.5530/ijper.20251782 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1429.pdf Objectives: Saussurea lappa Clark has shown preliminary promise in various biological contexts. This study investigates the antileishmanial, antitoxoplasmic, and antibacterial activities of methanolic extracts from S. lappa roots, focusing on key active components, Dehydrocostuslactone (DHL) and Dihydrodehydrocostus Lactone (DDHL). Materials and Methods: Bioassays were conducted to assess the extract's efficacy against Leishmania major, Toxoplasma gondii, Staphylococcus aureus, and Klebsiella pn Saussurea lappa, Antimcrobial, Molecular docking, Leishmania major, ADMET https://www.ijper.org/afzelin-prevents-against-lipopolysaccharide-induced-acute-lung-injury-and-sepsis 2026-04-25T06:56:16.585677+00:00 Afzelin Prevents against Lipopolysaccharide-Induced Acute Lung Injury and Sepsis via Inhibiting the Inflammatory Mediators 2025-07-28 10.5530/ijper.20251529 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1546.pdf Background: One of the main causes of death in critical care units and a serious consequence of sepsis is Acute Lung Injury (ALI). Studies have shown that afzelin reduces inflammation and oxidative damage. However, the potential protective effects of afzelin's anti-inflammatory and antioxidative activities against Lipopolysaccharide (LPS)-induced ALI and sepsis remain unclear. Materials and Methods: Male Wistar albino rats were injected intraperitoneally with LPS (5 mg/kg) in order to develop an Acute lung injury, Lipopolysaccharide, Afzelin, Anti-oxidative, Anti-inflammatory https://www.ijper.org/evaluating-myricetin-as-a-cdk2-inhibitor-in-lung-cancer-in-silico-and-in-vitro-a 2026-04-25T06:53:03.579698+00:00 Evaluating Myricetin as a CDK2 Inhibitor in Lung Cancer: In silico and in vitro Assessment of a Flavonoid-Based Small Molecule 2025-07-28 10.5530/ijper.20251924 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1385.pdf Background: Inhibiting Cyclin-Dependent Kinase 2 (CDK2) holds significant therapeutic potential for lung cancer by targeting a critical regulator of the cell cycle. CDK2 inhibition halts cancer cell proliferation, induces apoptosis, and disrupts tumor progression. Flavonoids have recognized to be exceedingly effective in treating a wide range of diseases, together with cardiovascular, immunological disorders, and cancer. Materials and Methods: This study intended to investigate the possible of f CDK2 inhibition, Flavonoids, Lung cancer, Molecular docking, Myricetin https://www.ijper.org/identification-and-comparison-of-phytoconstituents-of-essential-oil-and-methanol 2026-04-25T06:59:27.559744+00:00 Identification and Comparison of Phytoconstituents of Essential Oil and Methanolic Extracts of Leaves and Rhizomes of Elettariopsis curtisii Grown in Malaysia via GCMS Analysis 2025-07-28 10.5530/ijper.20251594 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1623.pdf Introduction: Elettariopsis curtisii (Zingiberaceae) is a high-value medicinal plant that has been used by the locals in Southeast Asia mainly to treat bloating and for postnatal care purposes. It contains many valuable phytoconstituents, including various essential oils that might be used in the treatment of various diseases. All previous studies were mainly carried out on the essential oil of rhizomes, and no or very limited information is available on other parts of the plant and methanolic e Elettariopsis curtisii, Essential oil, Methanolic extract, GCMS analysis https://www.ijper.org/pharmacological-evaluation-of-buchanania-lanzan-bark-against-alcohol-induced-liv 2026-04-25T06:53:55.617506+00:00 Pharmacological Evaluation of Buchanania lanzan Bark Against Alcohol Induced Liver Cirrhosis in Rats 2025-07-28 10.5530/ijper.20256322 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1444.pdf Aim: The study aimed to assess the potential of Buchanania lanzan bark extract in mitigating alcohol-induced liver cirrhosis effects. Objectives: Included evaluating antioxidant and anti-inflammatory properties, exploring interactions with liver disease-related proteins, investigating impacts on cirrhosis in rats and identifying underlying molecular pathways and targets. Materials and Methods: Network pharmacology study was carried out by cytoscape 3.7.2. First, bark extract was screened for in Alcoholic liver disease, Cirrhosis, Buchanania lanzan, Alcohol, Silymarin https://www.ijper.org/liquiritin-ameliorates-streptozotocin-induced-gestational-diabetes-in-pregnant-r 2026-04-25T06:54:05.504953+00:00 Liquiritin Ameliorates Streptozotocin-Induced Gestational Diabetes in Pregnant Rat Model by Inhibiting Inflammation and Oxidative Stress Responses 2025-07-28 10.5530/ijper.20251618 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1456.pdf Aim/Background: Gestational diabetes is a significant medical complication that can develop during pregnancy, characterized by impaired glucose tolerance. This condition poses risks to both the mother and the developing fetus. Effective management of gestational diabetes is crucial to mitigate the potential complications. The current work was aimed at studying the therapeutic roles of the liquiritin on Streptozotocin (STZ)-induced gestational diabetes in pregnant rat models. Materials and Method Oxidative stress, Glycated hemoglobin, Placenta, Liquiritin, Insulin https://www.ijper.org/formulation-and-evaluation-of-propolis-loaded-nanosponges-based-topical-anti-inf 2026-04-25T06:50:55.10238+00:00 Formulation and Evaluation of Propolis Loaded Nanosponges Based Topical Anti-Inflammatory Gel 2025-07-28 10.5530/ijper.20251073 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1312.pdf Objectives: To develop and evaluate a Propolis-Loaded Nanosponge (PLN)-based topical gel with potential anti-inflammatory, antifungal and antibacterial activities. Materials and Methods: PLNs were prepared using the emulsion solvent diffusion method with Ethyl Cellulose (EC) and Polyvinyl Alcohol (PVA) as key components. Various parameters, including particle size, Polydispersity Index (PDI), zeta potential, entrapment efficiency, production yield and drug release profile, were analyzed to deter Emulsion Solvent Diffusion Method, In vivo Anti-Inflammatory Study, Nanosponges, Propolis, Topical Gel https://www.ijper.org/repurposing-efavirenz-for-anticancer-therapy-with-curcumin-combination-in-solid 2026-04-25T06:51:55.851113+00:00 Repurposing Efavirenz for Anticancer Therapy with Curcumin Combination in Solid Lipid Nanoparticle Formulation 2025-07-28 10.5530/ijper.20257306 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1347.pdf Background: The aim of this study was to explore the potential of repurposing the anti-HIV drug Efavirenz (EFZ) in combination with Curcumin (CUR) for cancer therapy. EFZ is an antiviral drug and selective anti-HIV drug through its Non-Nucleoside Reverse Transcriptase Inhibition (NNRTI) mechanism. The poor survival rate of many cancers has been investigated by new and alternative therapies against immortal tumors. Repurposing is the best option because it minimizes the drug development timeline Repurposing, Efavirenz, Curcumin, Solid lipid nanoparticles, Anticancer activity, Breast cancer cells https://www.ijper.org/silencing-of-s100a16-in-cervical-cancer-cells-inhibits-cancer-cell-growth-by-ind 2026-04-25T06:56:03.215721+00:00 Silencing of S100A16 in Cervical Cancer Cells Inhibits Cancer Cell Growth by Inducing Autophagy via PI3K/AKT/ mTOR Signaling Pathway 2025-07-28 10.5530/ijper.20251170 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1534.pdf Objectives: Cervical Cancer (CC) ranks among the top 3 leading malignancies that affect the female reproductive system. This research focused on examining the impact of S100A16 silencing in HeLa and CaSki cells, alongside exploring the underlying molecular mechanisms involved. Materials and Methods: Cells were treated with si-S100A16 for a specific duration, as well as the impacts on migration, cell proliferation, cell cycle progression, apoptosis, as well as various signaling pathways were asse Autophagy, Cervical cancer, PI3K/AKT/Mtor, S100A16 https://www.ijper.org/navigating-usfda-inspectional-observations-an-analysis-of-trends-and-compliance 2026-04-25T06:48:22.806945+00:00 Navigating USFDA Inspectional Observations: An Analysis of Trends and Compliance from Fiscal Years 2019 To 2022 2025-07-28 10.5530/ijper.20250523 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1245.pdf The Food and Drug Administration (FDA) known for its rigorous regulatory oversight, conducts routine inspections in the pharmaceutical industry, utilizing Form 483 to highlight observed non-compliances. Inadvertent breaches of intricate FDA criteria can lead to unsuitable conditions. Substantial violations triggering the issuance of Warning Letters (WL) serve as official notifications of federal law non-compliance, necessitating timely and effective responses to avoid severe consequences such as Code of Federal Regulations-CFR, Fiscal Year-FY, Form 483 observation, Inspection, protocol, Regulatory oversight https://www.ijper.org/formulation-optimization-and-evaluation-of-naringenin-loaded-cubosomes-for-effec 2026-04-25T06:50:41.261091+00:00 Formulation, Optimization and Evaluation of Naringenin Loaded Cubosomes for Effective Management of Alzheimer's Disease 2025-07-28 10.5530/ijper.20251264 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1305.pdf Objectives: The goal of this work was to formulate a stable naringenin-loaded cubosomal in situ gel to improve naringenin absorption into the brain by direct nose-to-brain transfer. Materials and Methods: This investigation aimed to prepare, optimize and evaluate a cubosomal in situ gel containing naringenin, aimed at facilitating the delivery of the drug to the brain via nasal administration. Cubosomes were fabricated using a top-down methodology and optimization was conducted using 32 factoria Alzheimer’s disease, Brain targeting, Cubosomes, Naringenin, Nasal delivery https://www.ijper.org/modulatory-effects-of-dietary-saturated-versus-omega-3-fatty-acids-on-cognitive 2026-04-25T06:55:38.257551+00:00 Modulatory Effects of Dietary Saturated Versus Omega-3 Fatty Acids on Cognitive Impairment, Depressive-Like Behavior, HPA Axis Dysregulation and Systemic Inflammation in Monosodium Glutamate-Treated Young Male Rats 2025-07-28 10.5530/ijper.20251190 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1511.pdf Background and Objectives: Children consume fast food rich in saturated fats and flavor enhancers like Monosodium Glutamate (MSG). These agents might alter Hypothalamic-Pituitary- Adrenal (HPA) axis activity, inducing behavioral deficits. Consequently, we hypothesized that adding saturated fat to MSG-treated rats' diet could exaggerate their HPA axis response, behavioral deficits and systemic inflammation whereas dietary polyunsaturated omega-3 fatty acids could alleviate MSG-induced detrimental Fatty acids, Glucocorticoid receptors, miRNA218, TLR4 https://www.ijper.org/therapeutic-potential-of-lacidipine-against-3-nitropropionic-acid-induced-huntin 2026-04-25T06:56:37.81228+00:00 Therapeutic Potential of Lacidipine against 3- Nitropropionic Acid Induced Huntington's Disease: Based on Molecular Docking, Anti-Inflammatory and Neuroprotective Effects 2025-07-28 10.5530/ijper.20250579 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1565.pdf Background: Huntington's Disease (HD), a neurological ailment that leads to motor impairment, cognitive decline and psychiatric disorders, has limited treatment options. Hence, there is a pressing demand for new therapeutics to address the complex pathophysiology of HD. Lacidipine, a calcium channel blocker with antioxidative and anti-inflammatory properties, is a promising treatment option. Aims: This work aimed to assess the therapeutic potential of lacidipine against 3-Nitropropionic Acid (3- Antioxidants, Huntington's disease, Inflammation, Oxidative Stress, Neurotransmitters https://www.ijper.org/impact-of-pharmacist-led-training-on-breast-cancer-awareness-and-knowledge-a-qua 2026-04-25T06:59:45.905414+00:00 Impact of Pharmacist-Led Training on Breast Cancer Awareness and Knowledge: A Quasi-Experimental Pre-Post Study 2025-07-28 10.5530/ijper.20251409 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1633.pdf Background: Breast Cancer (BC) constitutes the primary cause of cancer-related mortality in females and BC burden is projected to rise to 3.19 million cases and 1.04 million deaths by 2040. Given the increasing prevalence of BC, all healthcare professionals, including pharmacists, are responsible for raising women's Awareness and Knowledge (AAK) of BC and its prevention. The aim of this research was to assess the impact of pharmacist-led training on women's AAK of BC, as well as to evaluate thei Breast cancer, Knowledge and awareness, Pharmacist, B-cas, Early diagnosis, Training https://www.ijper.org/exploring-factors-affecting-the-quantitative-analysis-of-vitexin-imperatorin-and 2026-04-25T06:55:14.419678+00:00 Exploring Factors Affecting the Quantitative Analysis of Vitexin, Imperatorin and Gallic Acid in Tri-Kaysornmas Formulation 2025-07-28 10.5530/ijper.20250137 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1493.pdf Background: The Tri-kaysornmas formula is one of the Thai traditional formulas in Thailand. Many phytochemical active compounds are found in this formula such as vitexin, imperatorin and gallic acid. Objectives: The current study explores the factors affecting the quantitative analysis of some active compounds in Tri-kaysornmas formulation. Materials and Methods: To quantify the content of these compounds, high-performance liquid chromatography was applied. A reverse-phase column, Hypersil ODS w Experimental design, HPLC, Response surface method, 3-level factorial design, Tri-kaysornmas formula https://www.ijper.org/screening-and-optimization-of-various-formulation-and-processing-parameters-for 2026-04-25T06:50:13.471909+00:00 Screening and Optimization of Various Formulation and Processing Parameters for the Development of Aquasomes 2025-07-28 10.5530/ijper.20250371 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1285.pdf Objectives: The research aims to enhance understanding of aquasome preparation, offering insights into optimizing formulations for potential applications in drug delivery systems. Materials and Methods: Aquasomes composed of lactose and trehalose as oligosaccharides encapsulate calcium phosphate cores. The cores synthesized by sonication and co-precipitation methods were screened based on % yield for calcium phosphate synthesis. Various coating methods were employed for the screening based on ca Aquasomes, Calcium Phosphate, Carbohydrate, Sonication, Plackett-Burman design https://www.ijper.org/atorvastatin-ameliorates-neuroinflammatory-response-in-experimental-intracerebra 2026-04-25T06:55:24.546506+00:00 Atorvastatin Ameliorates Neuroinflammatory Response in Experimental Intracerebral Hemorrhage Rats through the GSK-3β/β-Catenin Pathway 2025-07-28 10.5530/ijper.20250529 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1501.pdf Objectives: This study aimed to elucidate influence of Atorvastatin (ATV) on the neuroinflammatory response in experimental Intracerebral Hemorrhage (ICH) through the GSK-3β/β-catenin Signaling Pathway (SPW). Materials and Methods: Forty-five rats were randomly rolled into Sham, ICH (established using the Fredrik methodology) and ATV intervention (ICH model+10 mg/kg ATV) groups, each comprising 15 rats. Neurological deficits in rats were assessed using the Garcia methodology. Brain Water Content Atorvastatin, Experimental cerebral hemorrhage, Gsk-3β/β-catenin signaling, pathway, Inflammatory reaction, Neuroprotection https://www.ijper.org/wogonoside-mitigates-inflammation-and-cell-proliferation-via-modulation-of-nf-b 2026-04-25T06:54:34.46571+00:00 Wogonoside Mitigates Inflammation and Cell Proliferation via Modulation of NF-κB Signalling Pathway in DMBA-Induced Mammary-Preclinical Model 2025-07-28 10.5530/ijper.20256082 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1466.pdf Objectives: To hypothesis the effect of wogonoside against DMBA-induced Breast Cancer (BC) via TNF-α induced NF-κB signaling pathway a molecular appraoch. Materials and Methods: A 25 mg/kg Body Weight (BW), DMBA mixed dosage was used to produce BC with 1 mL olive oil by subcutaneous injection. We observed reduced body weight, elevated hepatic marker (AST, ALP, ACP and ALT), phase I (Cyt-b5 and Cyt-p450) and lipid peroxidative (TBARS and LOOH) markers and reduced antioxidant and xenobiotic enzyme Wogonoside, DMBA, Inflammation, Cell proliferation, NF-κB signaling https://www.ijper.org/enhancing-lyophilization-efficiency-a-review-of-processes-parameters-and-product 2026-04-25T06:48:43.450449+00:00 Enhancing Lyophilization Efficiency: A Review of Processes, Parameters and Product Preservation Strategies 2025-07-28 10.5530/ijper.20251071 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1254.pdf Lyophilization, often known as freeze-drying, is a critical process widely utilized in pharmaceuticals and biotechnology to preserve sensitive materials. This paper examines key parameters influencing lyophilization quality and efficiency, focusing on temperature control, pressure levels, ramp rate and duration, formulation and composition, container design, process parameters, material properties, and environmental factors. Precise temperature control is essential throughout the process to ensu Freeze-drying, Lyophilization, Pressure regulation, Ramp Duration, Ramp rate, Temperature control https://www.ijper.org/ameliorative-wound-healing-potency-of-koenimbine-via-attenuation-of-inflammatory 2026-04-25T06:53:33.895535+00:00 Ameliorative Wound Healing Potency of Koenimbine via Attenuation of Inflammatory Cytokines in Hyperglycemia-Induced Rodent Model 2025-07-28 10.5530/ijper.20251256 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1419.pdf Background: Managing wounds in diabetic patients requires specialized approaches due to their unique healing challenges. Diabetic wounds, particularly Diabetic Foot Ulcers (DFUs), often exhibit delayed healing, increased infection risks and complications related to poor blood circulation, nerve damage and reduced immune function. Therefore, treating diabetic wounds represents a significant clinical and social concern, necessitating urgent research efforts to develop effective treatments that enh Diabetic wounds, Hyperglycemia, Impaired healing, Inflammation, Phyto drug, Koenimbine https://www.ijper.org/neutralizing-effects-of-mimosa-pigra-stem-bark-against-selected-snake-venom-from 2026-04-25T06:54:48.361843+00:00 Neutralizing Effects of Mimosa pigra Stem-Bark against Selected Snake Venom from Malaysian Habitat 2025-07-28 10.5530/ijper.20257015 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1474.pdf Introduction: Mimosa pigra L. (M. pigra) regarded as significant undesirable weed in India, Africa, Australia, South-East Asia and some Pacific islands. Preliminary evidence of the use of the plants by rural community for medical purpose to cure snakebites. The purpose of this research was to validate the traditional claims and usefulness of M. pigra L. in the management of envenomation caused by various poisonous snakes found in Malaysia, such as the King Cobra, Malayan Pit Viper, Banded Krait Egg embryo model, Fibrinolytic, O. Hannah, M. pigra L, Phospholipase Inhibition, Activity, Snake venom https://www.ijper.org/modulation-of-tuberculosis-pathway-by-phaseolus-vulgaris-an-in-silico-approach 2026-04-25T06:53:23.87971+00:00 Modulation of Tuberculosis Pathway by Phaseolus vulgaris: An in silico Approach 2025-07-28 10.5530/ijper.20255884 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1408.pdf Aim/Background: Traditionally, Phaseolus vulgaris is used to treat common diseases. However, the affinity of its phytocompounds with proteins involved in the pathogenesis of Tuberculosis (TB) has not yet been illuminated. The present study was designed to elucidate the molecular mechanisms of Phaseolus vulgaris and its antituberculosis activity via compound-gene set pathway enrichment analysis, network pharmacology, docking studies and molecular dynamics simulation. Materials and Methods: The ph Tuberculosis-Related Pathways, Gene Set Enrichment, Molecular Dynamics, Simulation, Network Pharmacology, Phaseolus vulgaris https://www.ijper.org/pennogenin-exerts-anti-inflammatory-and-anti-nociceptive-effects-in-several-mode 2026-04-25T06:53:13.095688+00:00 Pennogenin Exerts Anti-inflammatory and Anti-nociceptive Effects in Several Models of Inflammation and Nociception in Mice 2025-07-28 10.5530/ijper.20251146 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1395.pdf Background: The nociceptive pain is a fundamental sensory response that works as a crucial protective mechanism for the human body. Chronic pain constitutes a substantial public health issue, impacting millions of individuals globally. Objectives: The present work focused at investigating the beneficial activities of pennogenin against nociceptive and inflammatory models induced by various stimuli. Materials and Methods: In the present study, the Swiss mice were utilized and the nociception was Capsaicin, Carrageenan, Hot plate method, Inflammation, Pain response, Pennogenin https://www.ijper.org/development-and-optimization-of-novel-microwave-assisted-extraction-for-rich-fla 2026-04-25T06:52:12.154578+00:00 Development and Optimization of Novel Microwave-Assisted Extraction for Rich-Flavonoids and Polyphenols from Dioscorea bulbifera Leaves by Response Surface Methodology 2025-07-28 10.5530/ijper.20250520 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1357.pdf Objectives: Microwave-Assisted Extraction (MAE) has emerged as a promising technique for the extraction of bioactive compounds from plant materials due to its efficiency and reduced processing time. In the present study, variables of MAE were optimized for maximizing the extraction of polyphenolic and flavonoid constituents from Dioscorea bulbifera leaves by Box-Behnken Design (BBD) of response surface methodology. Materials and Methods: Box-Behnken Design (BBD) was utilized to find the optimal Optimization, Polyphenols, Microwave, Box-Benkhen design https://www.ijper.org/antioxidant-assessment-of-albizia-lebbeck-slns 2026-04-25T06:51:37.273518+00:00 Antioxidant Assessment of Albizia lebbeck SLNs 2025-07-28 10.5530/ijper.20250803 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1334.pdf Aim: Nanotechnology is pivotal in the pharmaceutical industry, significantly augmenting drug properties and formulations. It enhances drug stability and controlled release, providing precise control over drug delivery systems, thereby maximizing therapeutic efficacy and minimizing adverse effects. Solid Lipid Nanoparticles (SLNs), composed of solid lipids, amalgamate lipid-based systems with nanotechnology to furnish controlled drug release, targeted delivery, and enhanced protection for encapsu Albizia lebbeck, Anti-oxidant Release, Nanotechnology, Neurological Diseases, Pharmaceutical Formulations, Solid Lipid Nanoparticles https://www.ijper.org/formulation-development-and-evaluation-of-iloperidone-loaded-nanosuspension-for 2026-04-25T06:51:11.748796+00:00 Formulation Development and Evaluation of Iloperidone Loaded Nanosuspension for Solubility Enhancement 2025-07-28 10.5530/ijper.20250282 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1323.pdf Introduction: Iloperidone is categorised as an antipsychotic drug and is used to treat schizophrenia. Iloperidone belongs to the Biopharmaceutics Classification System class II due to its low water solubility. Objectives: The primary aim of this work is to develop a nanosuspension of iloperidone to address issues such as low solubility and insufficient bioavailability. A 32 complete factorial design was employed to explore the influence of stabiliser concentration (A) and probe ultrasonication t Solubility, Nanosuspension, Pharmacokinetic, Schizophrenia, Factorial design https://www.ijper.org/co-delivery-of-sphingosomal-formulation-containing-bcl2-sirna-doxorubicin-for-th 2026-04-25T06:50:27.078216+00:00 Co-Delivery of Sphingosomal Formulation Containing BCL2 siRNA Doxorubicin for the Treatment of Lung Cancer 2025-07-28 10.5530/ijper.20257236 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1293.pdf Background: Lung cancer continues to pose a major challenge to global health, with limited therapeutic options and high mortality rates. One factor that contributes to this is the overexpression of BCL2, an anti-apoptotic protein that plays a role in tumor progression and resistance to therapy in lung cancer. To address this challenge, we investigated the potential of a co-delivery strategy using a sphingosomal formulation to simultaneously deliver BCL2 siRNA and Dox, a commonly used chemotherap BCL2 siRNA, Doxorubicin, TEM, Lung cancer, MTT https://www.ijper.org/in-vitro-and-in-silico-analysis-protosappanin-b-exerts-anti-tumor-activity-on-br 2026-04-25T06:54:59.904637+00:00 In vitro and in silico Analysis Protosappanin B Exerts Anti-Tumor Activity on Breast Cancer Cells via Activating Pro-Apoptotic Caspase Enzymes 2025-07-28 10.5530/ijper.20251723 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1483.pdf Background: Breast cancer is the most common cancer and the second leading cause of cancer-associated mortality in women globally. Breast cancer can metastasize or recur because of drug resistance and toxicity. Objectives: The present work focuses on assessing the impact of in vitro and in silico analysis Protosappanin B on the growth and apoptosis of MDA-MB-231 cells. Materials and Methods: The effect of different concentrations of Protosappanin B on the MDA-MB-231 cells was investigated using Protosappanin B, Caspases, Apoptosis, Breast cancer, Molecular docking https://www.ijper.org/herniarin-mitigates-high-fat-diet-induced-atherosclerosis-in-rats-via-regulation 2026-04-25T06:56:27.213147+00:00 Herniarin Mitigates High-Fat Diet-Induced Atherosclerosis in Rats via Regulation of Hyperlipidemia, Endothelial Dysfunction, Inflammation and Oxidative Stress 2025-07-28 10.5530/ijper.20251165 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1553.pdf Background: Atherosclerosis is a complex and multifactorial disease characterized by the buildup of plaque within the blood vessels, which can result in severe cardiovascular problems. Objectives: The present study attempted to elucidate the beneficial activities of herniarin against High-Fat Diet (HFD)-induced atherosclerosis in a rat model. Materials and Methods: The HFD-induced atherosclerosis rat model was utilized in the present study and treated with the 50 mg/kg of herniarin for 10 weeks. Atherosclerosis, Dyslipidemia, Endothelial Dysfunction, Herniarin, HMG-CoA, reductase https://www.ijper.org/herniarin-alleviates-lipopolysaccharide-induced-acute-lung-injury-in-mice-via-re 2026-04-25T06:52:52.753539+00:00 Herniarin Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Regulating Oxidative Stress, Inflammation and Apoptosis Mechanisms 2025-07-28 10.5530/ijper.20251124 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1375.pdf Background: Acute Lung Injury (ALI) is a severe, serious condition characterized by the development of pulmonary edema, hypoxemia and respiratory distress. Objectives: The current work was intended to disclosing the beneficial activities of the herniarin against LPS-induced ALI in murine model. Materials and Methods: The mice were exposed to LPS for 3 days via the intra-tracheal route to trigger the ALI response. Oral administration of herniarin was given for 3 days to the mice subsequent to the Apoptosis, Herniarin, Inflammation, Lung edema, Malondialdehyde, Pulmonary https://www.ijper.org/investigate-of-the-relationship-between-thinking-styles-and-classroom-management 2026-04-25T06:49:57.861449+00:00 Investigate of the Relationship between Thinking Styles and Classroom Management of the Teachers of Vocational Colleges 2025-07-28 10.5530/ijper.20253776 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1277.pdf Aim/Background: This study investigated the relationship between thinking styles and classroom management among teachers at X (anonymous) Vocational College of China during the academic year 2021-2022. Materials and Methods: The population of the study consisted of all 442 teachers at X Vocational College. Descriptive and inferential statistical techniques, including Fisher's Z test, were employed for data analysis. Results: The findings revealed that only the legislative and judicial thinking s Classroom Management styles, Teacher thinking, Thinking styles, Vocational College https://www.ijper.org/nose-to-brain-drug-delivery-an-update-on-clinical-challenges-and-progress 2026-04-25T06:49:06.088781+00:00 Nose-to-Brain Drug Delivery: An Update on Clinical Challenges and Progress 2025-07-28 10.5530/ijper.20253959 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1262.pdf In 1987 James Parkinson first describes Parkinson's Disease (PD) as a neurological syndrome. Over ten million people worldwide suffer with PD. The exact quantity of people suffered with PD is difficult to calculate because many people are not diagnosed in the early stages of the disease. As people age, they are more probable to develop PD. After Alzheimer's disease, it's the second utmost common age-related neurodegenerative condition. PD is a common prevalent neurological illness that causes si Parkinson’s disease, Nasal cavity, Nose-to-brain drug delivery https://www.ijper.org/students-perception-of-the-two-stage-collaborative-examination-based-on-the-focu 2026-04-25T06:49:36.86912+00:00 Students' Perception of the “Two-Stage” Collaborative Examination Based on the Focus Group Interview Method 2025-07-28 10.5530/ijper.20255653 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1272.pdf Background: Two-stage collaborative exams have been proven to improve students’ performance and enhance students’ learning efficiency. However, there is no quality study on students' perception of two-stage exams through Focus Group Discussion (FGD). Herein, the FGD method was implemented to explore students' perceptions of the two-stage exam. Materials and Methods: Third-year undergraduate pharmacy students participated in a two-stage exam with a natural product chemistry course. Students were Collaborative Examination, Focus Group Interview, Immediate Feedback, Learning, Efficiency https://www.ijper.org/strengthening-finerenone-assessment-a-central-composite-design-viewpoint-for-liq 2026-04-25T06:58:53.083508+00:00 Strengthening Finerenone Assessment: A Central Composite Design Viewpoint for Liquid Chromatographic Method Development 2025-07-28 10.5530/ijper.20251429 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1603.pdf Background: A RP-HPLC technique was created and proven for the measurement of Finerenone, a new medication currently being studied. The approach was improved to achieve excellent precision, accuracy, and sensitivity for use in pharmaceutical formulations. Materials and Methods: The separation by chromatography took place utilizing an isocratic elution method with a mobile phase of 0.01N dihydrogen of potassium orthophosphate and acetonitrile in a 65:35 (v/v) proportion. The velocity of the fluid Central composite design, Finerenone, Perturbation, Response surface plots, Statistical analysis https://www.ijper.org/in-silico-and-in-vivo-evaluation-of-antitumor-drugs-against-p-falciparum-3d7-inh 2026-04-25T06:55:51.842612+00:00 In silico and in vivo Evaluation of Antitumor Drugs against P. falciparum 3D7 Inhibit the Parasite Growth 2025-07-28 10.5530/ijper.20251797 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-4-1522.pdf Background: Plasmodium falciparum (P. falciparum) is the most lethal parasite that affectsmalaria in humans. The drugs such as Etoposide, Novobiocin, Netropsin, Nogalamycin and Daunorubicin may be useful in treating such diseases. Here, molecular docking study predicts the novel drug candidate. Further, computational and in vivo of the pharmacokinetic properties also helps to predict the drug candidate. Materials and Methods: At first, we optimized five antitumor drugs Etoposide, Novobiocin, Net Plasmodium falciparum, Drugs, FMO, DFT, Molecular Docking, ADME. Inhibition, Parasite growth https://www.ijper.org/assessing-knowledge-attitude-potential-barriers-and-analysis-of-motivational-fac 2026-04-25T07:13:44.341293+00:00 Assessing Knowledge, Attitude, Potential Barriers and Analysis of Motivational Factors of Blood Donation among Young Adults in an Endemic Area of Hemoglobinopathies in Saudi Arabia 2025-07-11 10.5530/ijper.20255821 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-1153.pdf **Background::** Blood and blood products are indispensable, lifesaving and essential in all components of healthcare systems globally. Blood (and blood product) transfusion is crucial for both routine and emergency medical practices. The adequacy of blood products is based on a sophisticated strategy for attracting and retaining donors, which is significantly influenced by the motivations that drive them. The success of Saudi Arabia's blood services may rely on understanding the motivational fa Blood, Donation, Voluntary Functions Inventory (VFI), Motivation, Barriers, Factor analysis, Knowledge, Awareness https://www.ijper.org/effect-of-wedelia-chinensis-leaf-extracts-against-ethylene-glycol-induced-urolit 2026-04-25T07:10:53.426951+00:00 Effect of Wedelia chinensis Leaf Extracts against Ethylene Glycol Induced Urolithiasis in Rats 2025-07-11 10.5530/ijper.20256632 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-1066.pdf **Background:** Finding a hyperoxaluria treatment that especially targets lowering oxalate excretion is essential due to the drawbacks of present urolithiasis treatments. It's interesting to note that Wedelia chinensis (Family: Asteraceae) leaves are used traditionally by several Indian tribes for treating renal disease. **Objectives:** The current study aimed to assess the effectiveness of W. chinensis leaf extracts as therapeutic agents in rats with experimentally induced calcium oxalate urol Antiurolithiatic activity, Herbal medicine, Phytochemical analysis, Phytotherapy, Renal calculi https://www.ijper.org/maslinic-acid-therapeutic-effect-in-rheumatoid-arthritis-through-activation-of-n 2026-04-25T07:10:45.421316+00:00 Maslinic Acid Therapeutic Effect in Rheumatoid Arthritis Through Activation of Nuclear Factor Erythroid 2 and Suppression of Nuclear Factor Kappa B as well as Apoptotic Markers 2025-07-11 10.5530/ijper.20250845 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-1057.pdf **Background::** Rheumatoid Arthritis (RA) is a chronic autoimmune condition characterized by persistent joint inflammation, resulting in pain, stiffness and degradation. Despite advances in understanding RA pathophysiology, its precise mechanisms remain complex. This article explores the processes involved in RA, including the interplay of inflammatory cascades, immune responses, cytokines and apoptosis. **Materials and Methods::** This study divided 32 Wistar rats into five groups. The model Apoptosis, Maslinic Acid, Rheumatoid Arthritis https://www.ijper.org/synergistic-suppression-of-dmba-induced-breast-cancer-in-rats-exploring-the-prev 2026-04-25T07:10:26.683394+00:00 Synergistic Suppression of DMBA-Induced Breast Cancer in Rats: Exploring the Preventive Potential of Diclofenac Sodium and D-Limonene Combination through mTOR Inhibition 2025-07-11 10.5530/ijper.20255758 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-1040.pdf **Background::** To examine the combination of Diclofenac sodium (DCF) and D-Limonene's (LIM) preventative effects against DMBA-induced breast cancer in a rat model. **Materials andMethods::** 7,12-Dimethylbenz[a]Anthracene (DMBA) was administered subcutaneously once to rats to trigger mammary cancer. DCF+LIM (DL) supplementation improved the level of antioxidants in mammary tissues, levels of lipids in serum, along with serum cytokines. The pathological alterations brought on by DL treatment w DMBA, Breast cancer, Diclofenac sodium, D-limonene, mTOR, Immunohistochemistry https://www.ijper.org/ivabradine-enhances-its-positive-impact-on-the-heart-muscle-myocardial-infarctio 2026-04-25T07:10:17.850408+00:00 Ivabradine Enhances its Positive Impact on the Heart Muscle/ (Myocardial Infarction) by Modulating Myocardial Nitric Oxide and ATP-dependent K+ Channels but not by Adenosine and Bradykinin Levels 2025-07-11 10.5530/ijper.20251359 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-1026.pdf **Background::** This study aimed to explore the cardioprotective effects of ivabradine and examine potential secondary mechanisms beyond the established role of If-HCN channel inhibition demonstrated in cellular studies. **Objectives::** Our hypothesis centered on the idea that Ivabradine could induce responses similar to ischemic preconditioning involving nitric oxide, adenosine, bradykinin, and ATP-dependent potassium channels. **Materials and Methods::** Ischemia-reperfusion injury was est Cardioprotection, Nitric oxide, KATP channels, Myocardial infarction, Ivabradine, animal models https://www.ijper.org/exploring-the-green-potential-of-quercetin-enhanced-strontium-oxide-nanoparticle 2026-04-25T07:09:42.714751+00:00 Exploring the Green Potential of Quercetin-Enhanced Strontium Oxide Nanoparticle Scaffold on Mesenchymal Stem Cells BMP-2 Expression 2025-07-11 10.5530/ijper.20257040 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-989.pdf **Aim::** The study aimed to create a scaffold infused with Quercetin-enhanced strontium oxide nanoparticles and assess its impact on BMP-2 expression in MSCs. **Materials and Methods::** Scaffold fabrication involved mixing 1% Hyaluronic acid, 0.5% carrageenan and 2% gelatin in a ratio of 6:1:3, adding 10 mg of quercetin-doped SrO nanoparticles and freezing at -20C for 12 hr and -80C for 24 hr. Dental Pulp Stem Cells (DPSC) cultured in DMEM F12 supplemented with 10% FBS were seeded onto the sc Bone Morphogenetic Protein 2, Mesenchymal Stem Cells, Nanoparticles, Quercetin, Tissue Scaffolds https://www.ijper.org/ich-m10-based-validation-of-a-novel-chromogenic-bioanalytical-method-for-quantif 2026-04-25T07:12:39.063332+00:00 ICH M10-Based Validation of a Novel Chromogenic Bioanalytical Method for Quantifying Hesperidin in Biological Samples 2025-07-11 10.5530/ijper.20251481 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-1117.pdf **Aim::** A Chromogenic bioanalytical approach had been developed as well validated for the assessment of specific compound hesperidin in accordance with the ICH M10 guidelines. 2,6-Dichloro quinone 4-chloro imide chromogenic reagent was used to develop the chromogenic method in the visible region. **Materials and Methods::** When the phenolic group in hesperidin reacts with Gibb's reagent at alkaline medium NaOH solution pH 9, a nucleophilic aromatic substitution reaction takes place, resultin 2, 6-Dichloro quinone 4-chloro imide, M10 ICH guidelines, Method validation, Protein Precipitation https://www.ijper.org/exploring-the-nephroprotective-efficacy-of-leucaena-leucocephala-seeds-in-mitiga 2026-04-25T07:09:19.652218+00:00 Exploring the Nephroprotective Efficacy of Leucaena leucocephala Seeds in Mitigating Cisplatin-Induced Renal Damage 2025-07-11 10.5530/ijper.20251234 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-969.pdf **Objectives::** The study aimed to evaluate the nephroprotective effects of the methanolic extract of Leucaena leucocephala seeds against Cisplatin-Induced Nephrotoxicity (CIN) in rats through biochemical, antioxidant and histopathological assessments. **Materials and Methods::** 2 experimental models were employed, using 30 Wistar rats in each model, divided into 5 groups of 6 animals each. In Model 1, the normal control group received normal saline (10 mL/kg, p.o.), the disease control group Cisplatin, Leucaena leucocephala, Nephroprotective, Nephrotoxicity https://www.ijper.org/novel-solar-micro-dryer-for-aromatic-and-medicinal-plants 2026-04-25T07:08:52.554756+00:00 Novel Solar Micro Dryer for Aromatic and Medicinal Plants 2025-07-11 10.5530/ijper.2025489 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-945.pdf **Background::** This paper focuses on an experimental investigation of an indirect solar dryer, specifically designed for drying aromatic and medicinal plants. **Objectives::** The purpose of this study is to utilize solar energy as a sustainable and efficient source of heat for the drying process, ensuring high-quality dried products. **Materials and Methods::** Our project aimed to study, design, implement, and experimentally evaluate an indirect solar micro-dryer. The study involves conduc Solar energy, Micro-solar dryer, Medicinal plants, Drying kinetics, Drying chamber https://www.ijper.org/effect-of-ethanol-extract-of-rosella-flower-hibiscus-sab-dariffa-l-on-the-expres 2026-04-25T07:08:29.039113+00:00 Effect of Ethanol Extract of Rosella Flower (Hibiscus sab- dariffa L.) on the Expression of Fibroblast Growth Factor-2 (FGF-2) and Matrix Metalloproteinase-1 (MMP-1) in the Healing Process of Incision Wounds in White Wistar Rats 2025-07-11 10.5530/ijper.20250752 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-921.pdf **Background::** This study investigated the effect of rosella flower petal (Hibiscus sabdariffa L.) ethanol extract gel on incision wound healing in a rat model of diabetes mellitus. Wounds are skin disorders that can be caused by internal or external factors. The wound healing process involves various growth factors, including Fibroblast Growth Factor-2 (FGF-2) and Matrix Metalloproteinase-1 (MMP-1). **Materials and Methods::** This study used a posttest-only controlled group design with male Ethanol Extract Rosella Flower Petals, Incision Wounds, White rat, Wistar strain https://www.ijper.org/apoptotic-effects-of-hypericum-dogonbadanicum-on-lung-and-gastric-cancer-cell-li 2026-04-25T07:08:18.817086+00:00 Apoptotic Effects of Hypericum dogonbadanicum on Lung and Gastric Cancer Cell Lines 2025-07-11 10.5530/ijper.20255499 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-910.pdf **Aim/Background::** Cancer is the second deadliest disease worldwide. Medicinal plants have been recognized for their cytotoxic and antitumor properties. This study aimed to assess the potential anticancer effects of the hydroalcoholic extract and essential oil of an Iranian endemic species, Hypericum dogonbadanicum, on AGS, A549 and a normal cell and the novel investigation of changes in caspase-3 and caspase-8 genes expression level. **Materials and Methods::** The essential oil and extract Cytotoxic, Essential oil, Ethanolic extract, Gene expression, Hypericum dogonbadanicum https://www.ijper.org/development-and-assessment-of-a-novel-absorption-base-and-permeability-enhanced 2026-04-25T07:07:48.378814+00:00 Development and Assessment of a Novel Absorption Base and Permeability-Enhanced Diclofenac Diethylamine Transdermal Cream 2025-07-11 10.5530/ijper.20251391 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-881.pdf **Background::** Background of the present research study was to investigate shea butter as absorption base and nerolidol as permeability enhancer for transdermal delivery of diclofenac diethylamine. **Hypothesis::** In present study, the leading objective is to enhance diffusion and permeability of diclofenac diethylamine by using shea butter as absorption base along with nerolidol as permeability enhancer. **Materials and Methods::** Total six batches were prepared (F0-F5) and estimated for Diclofenac diethylamine, Diffusion, Nerolidol and Shea butter https://www.ijper.org/preformulation-studies-and-pseudo-ternary-phase-diagram-development-for-dolutegr 2026-04-25T07:07:32.457325+00:00 Preformulation Studies and Pseudo-Ternary Phase Diagram Development for Dolutegravir Sodium: A Foundational Step toward SMEDDS Design 2025-07-11 10.5530/ijper.20252845 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-874.pdf **Background::** Dolutegravir Sodium (DTG) is a poorly soluble antiretroviral drug that will find it difficult to achieve oral bioavailability. Preformulation and screening of excipients are mandatory as a stepping stone in formulation development. **Objectives::** To conduct comprehensive preformulation studies and build pseudo-ternary phase diagrams for DTG with a view to informing future development of a stable SMEDDS formulation. **Materials and Methods::** UV spectrophotometry was used to Dolutegravir sodium, Ternary Phase Diagram, SMEDDS, Lipid Based Systems https://www.ijper.org/dolutegravir-solid-dispersions-as-oro-dispersible-tablets-to-ameliorate-the-inte 2026-04-25T07:07:21.09119+00:00 Dolutegravir Solid Dispersions as Oro-Dispersible Tablets: To Ameliorate the Integrase Inhibition Effect 2025-07-11 10.5530/ijper.20255690 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-863.pdf **Background::** Dolutegravir (DTG) is an integrase strand transfer inhibitor that prevents the integration of viral DNA into host cell DNA, which is one of the key phases in the life cycle of HIV, preventing the virus from multiplying inside the host. However, its therapeutic efficacy is constrained by its weak water solubility. **Objectives::** A simple conventional approach using Sulfobutylether--Cyclodextrin (SBE -CD) and Soluplus as carriers has been used to ameliorate the effect of DTG. D Ameliorative effect, Sulfobutylether-β-cyclodextrins, Lyophilization, Locust bean gum, and Soluplus® https://www.ijper.org/nepafenac-loaded-emulgel-for-controlled-ocular-delivery-in-vitro-and-ex-vivo-cha 2026-04-25T07:07:08.116024+00:00 Nepafenac Loaded Emulgel for Controlled Ocular Delivery: In vitro and Ex vivo Characterization 2025-07-11 10.5530/ijper.20251113 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-849.pdf **Objectives::** Emulgel, known for their unique combination of properties from both emulsions and gels, have attracted significant interest from the pharmaceutical and cosmetic industries for their versatility and usefulness. This research aims to design and assess a novel emulgel containing nepafenac for ocular drug delivery. **Materials and Methods::** Extensive literature research guided the formulation. Novel emulgel formulations (F1 to F9) blended O/W emulsion with castor oil, oleic acid, Ex vivo permeation, Nepafenac, Novel Emulgel, Ocular Drug Delivery, Ocular irritancy/ toxicity https://www.ijper.org/IndJPhaEdRes-59-4-814 2026-04-25T07:06:34.849323+00:00 A Comprehensive Review on Management of Insulin Resistance Disorder by Innovative Technologies and Advancement of Precision Medicinal Therapies 2025-07-11 10.5530/ijper.20250849 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-814.pdf The increasing prevalence of insulin resistance disorders, including type 2 diabetes and metabolic syndrome, underscores the urgent need for advanced diagnostic and therapeutic strategies. This review aims to explore the role of innovative precision medicine in revolutionizing the assessment and management of insulin resistance disorders. By integrating genetic, epigenetic and environmental data, precision medicine provides a more nuanced understanding of disease mechanisms and enables personali Genomic Biomarkers, Healthcare Integration, Insulin Resistance, Metabolic Disorders, Targeted Therapies https://www.ijper.org/potentially-inappropriate-psychotropic-drug-prescriptions-and-polypharmacy-among 2026-04-25T07:14:22.506103+00:00 Potentially Inappropriate Psychotropic Drug Prescriptions and Polypharmacy among Geriatric Home Healthcare Patients: A Cross-Sectional Study 2025-07-11 10.5530/ijper.20256020 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-1163.pdf **Introduction:** Comorbidities, psychotropic drug use and polypharmacy are common in elderly individuals. Research evaluating the psychotropic drug prescriptions among geriatric patients in a homecare health setting is limited. This study aimed to examine the medications of geriatric home healthcare patients regarding psychotropic drugs and polypharmacy and to assess their potential inappropriateness. **Materials and Methods:** Sociodemographic, clinical, drug prescription and home health serv Beer’s criteria, Clinical pharmacy, Geriatric cases, Home healthcare services, Polypharmacy, Psychotropic drugs https://www.ijper.org/a-statistical-based-estimation-of-candesartan-and-simvastatin-using-simultaneous 2026-04-25T07:12:10.776808+00:00 A Statistical Based Estimation of Candesartan and Simvastatin Using Simultaneous Estimation, First Order Derivative and Q Value Method by UV Spectrophotometry 2025-07-11 10.5530/ijper.20251345 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-1101.pdf **Aim/Background::** When combined with simvastatin, candesartan is a more potent antihypertensive medication than statins by itself. Therefore, to estimate Candesartan and Simvastatin concurrently in the mixture, a quick, economical and straightforward analytical method is needed. In order to evaluate candesartan and simvastatin using UV spectrophotometry, the current study set out to create and statistically validate an estimating approach utilizing simultaneous estimation, the first order der Analytical method validation, Candesartan, First order derivative method, Q-ratio method, Simultaneous equation method, Simvastatin, UV-visible spectroscopy https://www.ijper.org/antigenotoxic-activity-of-carissa-spinarum-l-leaves-extract-against-allethrin-in 2026-04-25T07:10:00.299298+00:00 Antigenotoxic Activity of Carissa spinarum (L.) Leaves Extract against Allethrin-Induced Genotoxicity in Allium cepa (L.) Meristematic Cells 2025-07-11 10.5530/ijper.20255649 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-1012.pdf **Aim::** The purpose of this research was to evaluate the phytochemical composition and antigenotoxic properties of Carissa spinarum leaf extract against allethrin-induced genotoxicity in Allium cepa (L.) meristematic cells. **Materials and Methods::** Phytochemical screening methods were employed to analyze and quantify the phenolic, flavonoid and terpenoid content, as well as to conduct histochemical assessments on the extract to understand the efficacy and its antigenotoxic mechanism. **Re Antigenotoxic, Carissa spinarum, Genotoxicity, Histochemical, Phytochemical https://www.ijper.org/evaluation-of-respirable-fraction-by-next-generation-impactor-for-beclomethasone 2026-04-25T07:10:36.445704+00:00 Evaluation of Respirable Fraction by Next Generation Impactor for Beclomethasone and Formoterol Fumarate Dihydrate Metered Dose Inhaler 2025-07-11 10.5530/ijper.20256558 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-1048.pdf **Introduction::** Asthma and Chronic Obstructive Pulmonary Disease are treated with a combination pharmaceutical aerosol (Pressurized Metered Dose Inhaler) dose form, such as Formoterol fumarate dihydrate and Beclomethasone dipropionate pressurized inhalation solution, contains 6 g and 100 g, respectively. **Aim::** The in vitro aerodynamic characteristic-respirable fraction using cascade impactors simulate drug particle deposition on patient's lungs. The current work aimed to evaluate respira Aerosol, Beclomethasone, Formoterol fumarate, HPLC, Inhaler, Pulmonary https://www.ijper.org/a-review-on-preparation-methods-of-drug-loading-solid-lipid-nanoparticles-with-t 2026-04-25T07:06:21.270122+00:00 A Review on Preparation Methods of Drug Loading Solid Lipid Nanoparticles with the Application in various Cancer Treatment 2025-07-11 10.5530/ijper.20257267 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-802.pdf The pharmaceutical and cosmetics industries, as well as the domains of research and clinical medicine, have all benefited from the advent of Solid Lipid Nanoparticles (SLN) as a promising new drug delivery technique. These SLN are receiving more and more interest as colloidal drug carriers for integrating hydrophilic or lipophilic medicines recently. Technology is the newest development in cancer therapy and numerous compounds are currently being studied for use in medication delivery. It aids t Solid lipid nanoparticles, Cancer, Microfluedics, Drug loading https://www.ijper.org/development-of-an-ion-chromatography-method-for-the-determination-of-organic-imp 2026-04-25T07:12:29.196988+00:00 Development of an Ion Chromatography Method for the Determination of Organic Impurities in Ferumoxytol 2025-07-11 10.5530/ijper.20251319 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-1110.pdf **Aim::** To the development of an ion chromatography method for the determination of organic impurities in Ferumoxytol. **Materials and Methods::** A new ion chromatographic method was employed for the precise and suitable quantification of organic impurities in Ferumoxytol drug. Specifically, LOD, LOQ, Linearity, and Accuracy evaluations were conducted to thoroughly validate each of these areas. **Results::** All the studied carbohydrate impurities showed linear ranges within 0.0005 to 0.003 Ferumoxytol, Ion Chromatography, Method Development, Organic Impurities, Pharmaceutical Analysis https://www.ijper.org/design-development-and-ex-vivo-evaluation-of-dorzolamide-nanoparticles-laden-con 2026-04-25T07:08:09.651453+00:00 Design Development and Ex vivo Evaluation of Dorzolamide Nanoparticles Laden Contact Lens for Management of Glaucoma 2025-07-11 10.5530/ijper.20256572 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-902.pdf **Background::** The current study aimed to design dorzolamide hydrochloride nanoparticle (NP)-laden contact lenses to control drug release for the effective management of glaucoma. **Materials and Methods::** Ionotropic gelation technique, using chitosan and sodium tripolyphosphate as the polymer and cross-linking agent, respectively, was employed for the formulation of nanoparticles. The formulation trials were optimized using a factorial design with JMP Pro software. The ANOVA-supported opti xxx https://www.ijper.org/formulation-and-evaluation-of-orally-disintegrating-tablet-containing-aripiprazo 2026-04-25T07:06:47.342919+00:00 Formulation and Evaluation of Orally Disintegrating Tablet Containing Aripiprazole in the Context of Quality by Design Approach 2025-07-11 10.5530/ijper.20256989 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-825.pdf **Aim/Background:** The objective of this research is to develop and enhance the formulation of aripiprazole rapid disintegrating tablets utilizing the Quality by Design (QbD) methodology. **Materials and Methods:** A full factorial experimental design with three levels was employed to analyze the influence of key factors, namely the concentration of the filler (starch), ludipress concentration and disintegrant concentration, on important quality attributes such as disintegration time, friabili Aripiprazole, Fast disintegrating tablets, Quality by design QBD, Stability, Super-disintegrants https://www.ijper.org/from-prescription-to-plate-evaluating-drug-drug-and-drug-food-interactions-in-th 2026-04-25T07:13:12.377017+00:00 From Prescription to Plate: Evaluating Drug-Drug and Drug-Food Interactions in the Prescriptions Dispensed in Community Pharmacies of Northern Cyprus 2025-07-11 10.5530/ijper.20251254 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-1141.pdf **Background::** The effect of drug on a person may be different than anticipated when the drug interacts with another drug/drugs the person is taking, or the food, beverages and dietary supplements the person is consuming. **Materials and Methods::** A total of 750 prescriptions were obtained from four different pharmacies of the Turkish Republic of Northern Cyprus. These prescriptions were evaluated for the drug-drug interactions, drug-food interactions and the legibility of the prescription Drug-food interactions, Drug-drug interactions, Polypharmacy, Prescriptions https://www.ijper.org/cassia-auriculata-stem-bark-ameliorates-the-hfdstz-induced-diabetes-in-both-in-v 2026-04-25T07:09:33.219076+00:00 Cassia auriculata Stem Bark Ameliorates the HFD+STZ-Induced Diabetes in both in vitro and in vivo Model 2025-07-11 10.5530/ijper.20256700 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-978.pdf **Background::** The secondary metabolites from natural herbs are exploited to treat various human ailments. The present study aimed to investigate the ameliorative effect of the methanolic extract of Cassia auriculata (C. auriculata) stem-bark in both in vitro and in vivo mice model. **Materials andMethods::** In vitro standard procedures were followed to determine the phytochemical profile. High-fat-diet+STZ was administered to 6-weeks old mice to induce type-2-diabetes. **Results::** In vit Type-2-diabetes, Cassia auriculata, High-fat diet, Glucose metabolism, Oxidative stress https://www.ijper.org/nanostructured-lipid-carrier-to-improve-oral-bioavailability 2026-04-25T07:06:10.066658+00:00 Nanostructured Lipid Carrier to Improve Oral Bioavailability 2025-07-11 10.5530/ijper.20255950 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-788.pdf Oral administration is the best way to administer both traditional and novel drugs because it decreases patient non-compliance and can also relieve the pain and discomfort associated with parenteral preparations. However, despite many benefits of oral formulations, a number of disadvantages significantly impair bioavailability. By helping with site-specific targeting, nanoparticles can stop drugs from breaking down across different physiological barriers. Lipidic systems are regarded as the most Nanostructured Lipid Carrier, Solid Lipid Nanoparticle, Bioavailability, Nanocarriers, Nanoparticles https://www.ijper.org/a-decade-of-medical-pharmacology-speciality-and-phd-theses-in-turkey-a-comparati 2026-04-25T07:10:09.200911+00:00 A Decade of Medical Pharmacology Speciality and Ph.D. Theses in Turkey: A Comparative Study 2025-07-11 10.5530/ijper.20255889 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-1020.pdf **Objectives:** This study aimed to analyse the characteristics and publication trends of medical pharmacology specialty and Ph.D. theses. **Materials and Methods:** Medical pharmacology theses published in Turkey between 2010 and 2020, were included. Data on the study topic, funding source and publication year, were collected from the National Thesis Center's online archive. A follow-up search was conducted to evaluate the publication status of the theses, using databases such as the Web of Sc Pharmacology, Ph.D. Thesis, Specialty Thesis, Research Trends, Bibliometric Analysis, Publication Status https://www.ijper.org/quantification-of-miconazole-nitrate-and-eugenol-in-formulated-emulgel-by-planar 2026-04-25T07:12:55.66157+00:00 Quantification of Miconazole Nitrate and Eugenol in Formulated Emulgel by Planar Chromatography along its Stability Studies 2025-07-11 10.5530/ijper.20255177 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-1134.pdf **Introduction::** Fungal infections are rapidly increasing and combination therapy using Miconazole Nitrate (MCZ) and Eugenol (EGN), may offer a promising approach for developing new antifungal medications. **Objectives::** The purpose of the demonstrated work was to develop and validate a stability-indicating HPTLC method for concurrent measurement of MCZ and EGN in formulated emulgel. **Materials and Methods::** The separation technique of the HPTLC method was aided by pre-coated silica gel Eugenol, Miconazole Nitrate, HPTLC, Emulgel, Topical formulation https://www.ijper.org/an-improved-method-development-and-validation-for-the-quantification-of-clomifen 2026-04-25T07:12:47.204025+00:00 An Improved Method Development and Validation for the Quantification of Clomifene in Pharmaceutical Formulation and Biological Matrix by LC-MS/MS 2025-07-11 10.5530/ijper.20255465 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-1126.pdf **Aim::** The major objective of current work was to create sensitive tandem mass spectrometric method using electrospray ionization and liquid chromatography for quantifying Clomifene in biological matrices **Materials and Methods::** A stationary Phenomenex C18 column with dimensions of 50 mm4.6 mm and 5 sizes of particles were used to achieve chromatographic elution. Isocratic eluting of components was done using methanol and 0.10% V/V HCOOH in the fraction of 85:15V/V as a movable phasic s Clomifene, LC-MS/MS, USFDA guidelines, Validation, Stability, Linearity, Matrix effect https://www.ijper.org/synthesis-characterisation-and-evaluation-of-benzimidazoles-containing-biphenylc 2026-04-25T07:11:40.086022+00:00 Synthesis, Characterisation and Evaluation of Benzimidazoles Containing Biphenylcarbonylpiperazine at C-2 Position for Antipsychotic Activity 2025-07-11 10.5530/ijper.20256783 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-1090.pdf **Aim/Background::** The development of antipsychotic medications with a better clinical profile and fewer neurological side effects is still necessary. Since it is widely known that a dopamine D2 opposing component is required for antipsychotic efficaciousness, the majority of modern pharmacological treatments under investigation are based on the development of medications that partially or entirely interfere with dopamine D2-like receptors. Compounds that selectively block a subtype of dopamin Antipsychotic, Benzimidazole, Biphenyl, Piperazine, Schizophrenia https://www.ijper.org/exploring-the-ameliorative-potential-of-barleria-cristata-in-cognitive-dysfuncti 2026-04-25T07:09:01.236939+00:00 Exploring the Ameliorative Potential of Barleria cristata in Cognitive Dysfunction Rat Model: Investigating Behavioral, Biochemical and Cellular Changes 2025-07-11 10.5530/ijper.20250416 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-950.pdf Background: Cognitive impairment is a pervasive and perplexing concern that transcends the boundaries of various neuropsychiatric disorders like schizophrenia and Alzheimers. As research continues to unravel the intricacies of Barleria cristata's bioactive compounds, it offers promising prospects for the new therapeutic agents in the realm of natural medicine. <strong>Materials and Methods: In present study the ameliorative effect of methanolic leaf extract of Barleria cristata in ketamine induc Barleria cristata, Ketamine, Schizophrenia, Step down latency https://www.ijper.org/ethnomedicinal-plants-of-north-eastern-india-unveiling-phenolic-composition-and 2026-04-25T07:09:51.060258+00:00 Ethnomedicinal Plants of North-Eastern India: Unveiling Phenolic Composition and Antioxidant Activity for Skin Health 2025-07-11 10.5530/ijper.20254855 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-995.pdf **Background::** Skin diseases are a major health concern due to their link with oxidative stress, inflammation, tissue damage and impaired skin function. Antioxidants play a crucial role in addressing these issues and offer potential therapeutic benefits. Medicinal plants rich in antioxidants can combat pathogen resistance to pharmaceutical treatments. The primary objective of this study was to explore and analyze the antioxidant activity and composition of both free and bound phenolic compound Ethnomedicinal plants, Skin diseases, Antioxidant properties, Phenolics by HPLC https://www.ijper.org/synthesis-and-characterization-of-novel-hpmc-phthalate-succinate-polymers-for-ph 2026-04-25T07:06:58.053865+00:00 Synthesis and Characterization of Novel HPMC Phthalate Succinate Polymers for Pharmaceutical Applications 2025-07-11 10.5530/ijper.20251074 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-837.pdf **Aim::** The current article aimed to synthesize new HPMC derivative polymers by esterification method. **Background::** 2 most common causes of drug candidate failures are a lack of effectiveness and PK/bioavailability issues. Various strategies have been employed to enhance the aqueous solubility of pharmaceuticals, with one significant technique being solid dispersion. In the last decade, most drug products launched using the solid dispersion technique have utilized HPMCAS polymer as a carr Dissolution enhancement, Hydroxypropyl methylcellulose acetate succinate, Hydroxypropyl methylcellulose phthalate succinate, Polymer synthesis, Solid dispersion https://www.ijper.org/exploring-phytocompounds-interaction-with-multi-serotype-dengue-virus-ns5-mtase 2026-04-25T07:08:44.574338+00:00 Exploring Phytocompounds’ Interaction with Multi-Serotype Dengue Virus NS5-MTase: Insights into Binding Affinity and Activity 2025-07-11 10.5530/ijper.20251313 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-930.pdf **Background:** Dengue Virus (DENV) infection poses a formidable global health threat, spanning from mild breakbone fever to severe conditions such as dengue hemorrhagic fever and dengue shock syndrome. The NS5-MTase enzyme assumes a pivotal role in DENV replication by catalyzing methylation at guanine N7 and ribose 2'-OH during viral cap structure formation. **Materials and Methods:** Targeting the MTase presents a promising strategy for combating flavivirus infections. In recent years, plant- Baicalin, Dengue, Methyltransferase, Molecular Dynamics simulations, QSAR, Virtual screening https://www.ijper.org/quality-by-design-based-formulation-and-development-of-a-novel-bi-compound-pharm 2026-04-25T07:07:58.036028+00:00 Quality by Design Based Formulation and Development of a Novel Bi-Compound Pharmaceutical Capsule: An Innovative Approach for the Treatment of Hypertension 2025-07-11 10.5530/ijper.20252275 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-890.pdf **Objectives::** This study aimed to develop a novel bi-compound pharmaceutical capsule containing nifedipine gastro-retentive floating microspheres and telmisartan immediate-release solid dispersions using a Quality by Design (QbD) approach. **Materials and Methods::** QbD methodology was applied to optimize the formulations and ensure product quality. Risk assessment tools identified the Critical Material Attributes (CMA) and Critical Process Parameters (CPP). A Plackett-Burman screening desi Hypertension, Combination therapy, Quality by Design (QbD), Bi-compound pharmaceutical capsule, Gamma scintigraphy https://www.ijper.org/mesoporous-silica-nanoparticles-a-promising-portal-for-diagnosis-and-treatment-f 2026-04-25T07:05:47.569259+00:00 Mesoporous Silica Nanoparticles: A Promising Portal for Diagnosis and Treatment for Chronic Diseases 2025-07-11 10.5530/ijper.20251674 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-776.pdf Nanotechnology is a promising technology in the creation of novel strategies in the field of the healthcare domain. Nano distribution of pharmaceuticals emerging new features for enhanced targeted drug delivery in the diagnosis of chronic disorders like cancer, AIDs and Alzheimers disease. Numerous types of nanocarriers were established in the Nanotechnology. Mesoporous Silica Nanoparticles (MSNs) are an inorganic form of nanoparticle having specific characteristics like tunable pore size, parti Bioimaging, Biomedical applications, Bio-sensing and cell tracing, Controlled release, pH stimuli responsiveness, Targeted drug delivery, Theranostics https://www.ijper.org/analysis-of-indian-pharmaceutical-industry-and-trade-competitiveness-using-revea 2026-04-25T07:14:37.247878+00:00 Analysis of Indian Pharmaceutical Industry and Trade Competitiveness: Using Revealed Comparative Advantage (RCA) 2025-07-11 10.5530/ijper.20250648 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-1175.pdf **Introduction::** This paper examines the growth of the Indian pharmaceutical sector, the changing dynamics and the export competitiveness of therapeutic segments. Further, this study compared the export competitiveness of the therapeutic segments with that of the leading exporting countries. Trade-Related Aspects of Intellectual Property Rights (TRIPS) is considered an emerging point in India's pharmaceutical sector's history. Having skills in making off-patent drugs at low cost contributes to Export competitiveness, Patents, Pharmaceutical industry, Revealed Comparative Advantage https://www.ijper.org/cytotoxicity-assay-antioxidant-activity-and-investigation-of-bioactive-compounds 2026-04-25T07:09:10.839169+00:00 Cytotoxicity Assay, Antioxidant Activity and Investigation of Bioactive Compounds Using GC-MS in the Leaves Extracts of Cinnamomum tamala (Buch. -Ham.) 2025-07-11 10.5530/ijper.20251207 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-961.pdf **Background::** Cinnamomum tamala (Lauraceae), commonly known as Tejpaat or Bay leaves, find application in foods, along with traditional uses for curing a number of ailments. The objective of the current study was to investigate the cytotoxic efficacies of different solvent extracts of Cinnamomum tamala (Buch. -Ham.) leaves on some cancer cell lines. **Materials and Methods::** The powdered leaves were extracted using petroleum ether, chloroform, ethyl acetate and ethanol and tested for the p Antioxidant, Cancer cell lines, Cinnamomum tamala, Cytotoxic Activity https://www.ijper.org/a-convenient-synthesis-of-glutarates-derivatives-application-theoretical-dft-cal 2026-04-25T07:11:30.405743+00:00 A Convenient Synthesis of Glutarates Derivatives: Application, Theoretical DFT Calculations and Molecular Docking Study 2025-07-11 10.5530/ijper.20255204 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-1083.pdf **Background::** An easy and convenient access to a novel Gluatarate Derivatives (DCG) was successfully synthesized, using an unusual successive SN2-SN2 reaction of 1,4-Diazabicyclo [2.2.2] Octane (DABCO) then KCN, on the available vinyl bromide. Fukui functions, molecular electrostatic potential and HOMO-LUMO energy of the component Gluatarate Derivatives (DCG) 2b and 3b were computed using Density Functional Theory (B3LYP/6-311+G(d,p)). The technique of molecular docking was studied to predict Glutarates derivatives, NMR Spectroscopy characterization, DFT calculations, Molecular Docking, Anti-Alzheimer against https://www.ijper.org/anti-inflammatory-activity-of-gallic-acid-by-suppression-of-cyclooxygenase-lipox 2026-04-25T07:11:06.826909+00:00 Anti-Inflammatory Activity of Gallic Acid by Suppression of Cyclooxygenase, Lipoxygenase and Nitric Oxide 2025-07-11 10.5530/ijper.20254515 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3s-1074.pdf **Background::** Gallic acid, trihydroxy benzoic acid is a phenolic compound abundant in various fruits and plants with potent antioxidant and anti-inflammatory properties. This study aims to investigate dual COX LOX inhibition in silico and in vitro to exhibit safer anti-inflammatory potential sparing gastrointestinal toxicity observed with selective COX inhibitors. **Materials and Methods::** Anti-inflammatory activity of gallic acid was evaluated in vitro by measuring cyclooxygenase, lipoxyg Gallic acid, Diclofenac, Cyclooxygenase, Lipoxygenase, Nitric oxide, iNOS, Anti-inflammatory https://www.ijper.org/perception-of-undergraduate-pharmacy-students-of-case-based-learning-as-a-tool-i 2026-04-13T05:54:02.327672+00:00 Perception of Undergraduate Pharmacy Students of Case-Based Learning as a Tool in Teaching Pharmacy Management Course 2025-05-09 10.5530/ijper.20250304 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-882.pdf Aim/Background: Case-Based Learning (CBL) has become a significant pedagogical approach in higher learning institutions, especially in disciplines that involve problem-solving and critical thinking. This research aims at identifying the perception that undergraduate pharmacy students have toward CBL in a pharmacy management course. Materials and Methods: In this descriptive research study, 69 fourth-year pharmacy students from a university in Saudi Arabia were chosen. The data was collected thro Case-Based Learning (CBL), Pharmacy Management Education, Undergraduate, Pharmacy Students, Active Learning Strategies, Pedagogical Approaches in Pharmacy https://www.ijper.org/optimization-and-validation-of-in-vitro-proliferation-of-rats-peripheral-blood-m 2026-04-13T05:54:02.327672+00:00 Optimization and Validation of in vitro Proliferation of Rat’s Peripheral Blood Mononuclear Cells (PBMNCs) Stimulated with Phytohemagglutinin-M (PHA-M) for Enhanced Immune Response 2025-05-09 10.5530/ijper.20250943 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1128.pdf Objectives: The main objective of this study is to develop a method for in vitro T cell proliferation from rat peripheral blood mononuclear cells. Materials and Methods: The study involved female adult Albino Wistar rats, acclimatized for a week and used mononuclear cells for T cell enrichment. The cells were cultured in 24 and 6-Well Plates (WP) in the presence of PHA-M and analyzed for cytokines, cell counts, DNA content and morphology characteristics. Key Facts: MNCs were isolated and quantif Cell count, Cytokine, DNA, Immune Response, Mononuclear cells, Proliferation, T-cells https://www.ijper.org/formulation-and-optimization-of-fast-dissolving-thin-strips-of-desvenlafaxine-hc 2026-04-13T05:54:02.327672+00:00 Formulation and Optimization of Fast Dissolving Thin Strips of Desvenlafaxine HCl by Using Quality by Design (QbD) Approach 2025-05-09 10.5530/ijper.20255095 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-913.pdf Aim: The present work was aimed to formulate and optimize fast dissolving thin strips of Desvenlafaxine Hydrochloride using QbD. Materials and Methods: The solvent casting method was used to formulate fast dissolving thin strips. The drug (Desvenlafaxine HCl), polymer (pullulan), super disintegrant (Croscarmellose sodium), plasticizer (Poly Ethylene Glycol- (PEG-400), saliva stimulating agent (citric acid), sweetening agent (mannitol and aspartame) and water (solvent) were used in the preparatio Crospovidone, Disintegration time, Dissolution efficiency, Dysphagia, Fast dissolving, strips, Microcystalline Cellulose, Quality by Design https://www.ijper.org/microwave-assisted-nanocomposites-for-solubility-enhancement-of-azelnidipine-dev 2026-04-13T05:54:02.327672+00:00 Microwave-Assisted Nanocomposites for Solubility Enhancement of Azelnidipine: Development, Optimization and in vivo Pharmacokinetic Study in Rats 2025-05-09 10.5530/ijper.20256726 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-889.pdf Background: The enhancement of drug solubility and bioavailability for orally administered medications remains a significant challenge in pharmaceutical formulations. This study focused on Azelnidipine, a poorly water-soluble drug used to treat hypertension, aiming to improve its solubility and delivery using microwave-assisted nanocomposite technology. Materials and Methods: A 3² factorial design was utilized to optimize the concentrations of polymers HPMC K100M and PVK K-30 in the nanocomposit Azelnidipine, Solubility enhancement, Microwave-assisted nanocomposites, In vivo, pharmacokinetics, Nanocomposite https://www.ijper.org/synthesis-and-characterization-of-some-impurities-of-bisoprolol-beta-adrenocepto 2026-04-13T05:54:02.327672+00:00 Synthesis and Characterization of Some Impurities of Bisoprolol: Beta-Adrenoceptor Antagonist 2025-05-09 10.5530/ijper.20250721 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1180.pdf Aim/Background: Throughout the drug development process, maintaining control over impurities and keeping them within specified limits is of paramount importance in the production of high-quality drugs. Numerous studies have been dedicated to synthesizing impurities and elucidating their structures to support the purification method. Bisoprolol, a selective beta-adrenoceptor antagonist that predominantly targets β1 receptors, is primarily employed to treat conditions like high blood pressure and Bisoprolol, Dimer, Impurities, Synthesis https://www.ijper.org/nephroprotective-effects-of-piperlongumine-against-streptozotocin-induced-diabet 2026-04-13T05:54:02.327672+00:00 Nephroprotective Effects of Piperlongumine against Streptozotocin-Induced Diabetic Kidney Disease in Rats 2025-05-09 10.5530/ijper.20251645 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1118.pdf Background: Diabetes mellitus is a chronic metabolic disorder defined by hyperglycemia, potentially resulting in various consequences, such as diabetic kidney disease. Diabetic kidney disease is a major health concern associated with heightened morbidity and mortality risk. Aim/Objectives: The current study was performed to study the beneficial effects of piperlongumine against Streptozotocin (STZ)-induced diabetic renal dysfunction and renal fibrosis in an experimental rat model. Materials and Glomerulosclerosis, Piperlongumine, Hyperglycemia, Streptozotocin, Insulin https://www.ijper.org/evaluation-of-advertisements-regarding-aphrodisiac-herbal-products-in-selected-o 2026-04-13T05:54:02.327672+00:00 Evaluation of Advertisements Regarding Aphrodisiac Herbal Products in Selected Online Shopping Platforms 2025-05-09 10.5530/ijper.20255209 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1194.pdf Background: Aphrodisiac is a substance used to treat sexual dysfunction and boost performance in sexual activity. Aphrodisiac Herbal Products (AHP) was associated with numerous safety issues. The internet has become a pivotal source of health information and platform for purchasing AHP these days. There is already a regulation in place for the advertisement of herbal products; however, the implementation of the regulation is yet to be investigated. Materials and Methods: This study aimed to eval Aphrodisiac, Herbal products, Men’s health, Malaysia, Online shopping, Sex, enhancement products, Web advertisement https://www.ijper.org/development-of-genistein-loaded-nanogel-for-skin-aging-an-in-vitro-and-in-vivo-s 2026-04-13T05:54:02.327672+00:00 Development of Genistein-Loaded Nanogel for Skin Aging: An in vitro and in vivo Study 2025-05-09 10.5530/ijper.20256890 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-901.pdf Background: Generating Reactive Oxygen Species (ROS) at high altitudes causes several disorders, including skin aging. Genistein (GN) is a potent herbal bioactive compound found in many herbs like Soy GN has been reported to have several beneficial health effects, including antioxidant and photoprotection activities. However, their therapeutic efficacy is limited because of low solubility and poor oral bioavailability. Objectives: The current work was designed to formulate a nanoemulsion of GN i Nanogel, Oxidative stress, Bioavailability, UV rays, Genistein, Nanoemulsion https://www.ijper.org/protective-effect-of-niosomal-gel-of-azadirachta-indica-against-ulcerative-colit 2026-04-13T05:54:02.327672+00:00 Protective Effect of Niosomal Gel of Azadirachta indica against Ulcerative Colitis induced by Dextran Sodium Sulfate (DSS) and Tri Nitro Benzene Sulfonic Acid (TNBS) 2025-05-09 10.5530/ijper.20253800 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1024.pdf Aim: This study focuses on finding the protective action of niosomal gel of Azadirachta indica (neem) leaf extract in ulcerative colitis. Materials and Methods: The pharmacological in vivo model conducted here was Dextran Sodium Sulphate (DSS) model of mice colitis and Trinitro Benzene Sulfonic Acid (TNBS) induced ulcerative colitis in rats. Results: In DSS model, the niosomal gel of neem leaf extract at 500 mg/kg dose was found to be significant (**p<0.01). While in TNBS model the significance Dextran sodium sulphate, IBD, Irritable Bowel Syndrome (IBS), Trinitro benzene, sulfonic acid https://www.ijper.org/natural-compounds-and-their-small-molecule-derivatives-as-pi3-kinase-inhibitors 2026-04-13T05:54:02.327672+00:00 Natural Compounds and Their Small Molecule Derivatives as PI3-Kinase Inhibitors against Cancer 2025-05-09 10.5530/ijper.20256422 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1067.pdf Objectives: Earlier findings revealed the importance of different natural compounds and synthetic drugs in the treatment of cancer by targeting Phosphoinositide 3-Kinase (PI3K). In the direction to discover novel PI3K inhibitors, the present study includes the generation of fragment derivatives. Natural compounds and FDA-approved synthetic drugs were selected for screening against PI3K by using different computational methodologies. Materials and Methods: The top ranked compounds dehydroglyasper Cancer, Dehydroglyasperin D, Honokiol, Molecular docking, Phosphoinositide, 3-kinase, PI3K inhibitor https://www.ijper.org/effects-of-astaxanthin-supplement-on-cardiovascular-health-a-systematic-review-a 2026-04-13T05:54:02.327672+00:00 Effects of Astaxanthin Supplement on Cardiovascular Health: A Systematic Review and Meta-Analysis 2025-05-09 10.5530/ijper.20256138 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-865.pdf Background: The objective of this study was to evaluate the effects of astaxanthin intake on the cardiovascular disease-related indicators. Materials and Methods: Fives databases, including PUBMED, CNKI, WEIPU, WAN FANG and Clinical Trials were searched up to June 30, 2023. The random-effects model was used to calculate the summary risk. A total of 17 studies were included in this meta-analysis and a total of 1101 subjects' data were included in the analysis. In all included literature studies, Astaxanthin, Cardiovascular Health, Efficacy, Hyperlipidemia, Meta-Analysis https://www.ijper.org/fabrication-of-polymeric-matrix-type-transdermal-patch-containing-glimepiride-fo 2026-04-13T05:54:02.327672+00:00 Fabrication of Polymeric Matrix Type Transdermal Patch Containing Glimepiride for Therapeutic Management of Type-2 Diabetes 2025-05-09 10.5530/ijper.20250924 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-936.pdf Aim: This study aims to enhance Glimepiride's (GMP) solubility and transdermal permeability by developing a matrix-type transdermal patch to improve systemic bioavailability, circumvent first- pass metabolism and decrease dosing frequency. Materials and Methods: Matrix-type transdermal patches were developed using the solvent-casting method. Initially, formulations were prepared with varying concentrations of polymers and GMP. Formulations were optimized using a quality-by-design approach using Glimepiride, Matrix-type patch, Solid dispersion, Transdermal drug delivery, Type-2, Diabetes https://www.ijper.org/topical-chitosan-based-nanogel-of-filipendula-ulmaria-meadowsweet-extract-agains 2026-04-13T05:54:02.327672+00:00 Topical Chitosan-Based Nanogel of Filipendula ulmaria (Meadowsweet) Extract against Bacterial Infections: Development, Characterization, Optimization and in vitro Studies 2025-05-09 10.5530/ijper.20251041 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-982.pdf Background: Skin infections caused by bacterial pathogens pose a significant health concern, necessitating the exploration of innovative therapeutic approaches. This study aimed to investigate the potential therapeutic efficacy of Filipendula ulmaria extract-loaded chitosan nanoparticles against bacterial skin infections. Materials and Methods: The aerial part of the Filipendula ulmaria plant was extracted using the Soxhlet technique with water and methanol in a 70:30 v/v ratio. The resulting ex Antibacterial, Chitosan, Dermatokinetics, Filipendula ulmaria, Nanogel, Nanoparticles https://www.ijper.org/quality-by-design-assisted-optimization-of-gemcitabine-loaded-nanocochleates 2026-04-13T05:54:02.327672+00:00 Quality by Design Assisted Optimization of Gemcitabine Loaded Nanocochleates 2025-05-09 10.5530/ijper.20250838 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1007.pdf Background: Gemcitabine hydrochloride (GEM) is a drug of choice in treatment of various malignancies, but has limited use for oral drug delivery because of its very short plasma half-life. Nanocochleates can be a promising nanocarrier for improving oral delivery of GEM. Materials and Methods: The Trapping method was utilised to prepare nanocochleates of GEM. To find a wide range of potential causes influencing particle size and entrapment efficiency, the Ishikawa diagram was employed as a cause Gemcitabine hydrochloride, Nanocochleates, Optimization, Particle size, Entrapment, efficiency, Korsmeyer-peppas kinetic model https://www.ijper.org/saponarin-and-its-role-in-nursing-care-for-the-adjuvant-treatment-of-mda-mb-231 2026-04-13T05:54:02.327672+00:00 Saponarin and its Role in Nursing Care for the Adjuvant Treatment of MDA-MB-231 Triple-Negative Breast Cancer Cells: An in vitro and in silico Approach 2025-05-09 10.5530/ijper.20250959 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1093.pdf Background: Breast cancer caused 670,000 deaths worldwide in 2024. Saponarin (SAP) is mostly present in vegetables and citrus fruits and has demonstrated encouraging anti-proliferative properties in various studies. This investigation examines the possible synergic effects of SAP in breast cancer MDA-MB-231 cells. Materials and Methods: Breast cancer cells MDA-MB-231 cells were undergone to various doses of SAP treatment to assess cell viability, Lactate Dehydrogenase (LDH) assay and measure the Antioxidants, Breast Cancer, Saponarin, “in silico studies”, “Molecular Docking” https://www.ijper.org/observation-on-the-effect-of-xiao-chaihu-tang-combined-with-acupuncture-on-the-p 2026-04-13T05:54:02.327672+00:00 Observation on the Effect of Xiao Chaihu Tang Combined with Acupuncture on the Postoperative Nutritional Status of Lung Cancer Patients 2025-05-09 10.5530/ijper.20251049 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1078.pdf Aim: Lung Carcinoma (LC) is still one of the malignant neoplastic diseases with the fastest-growing morbidity and mortality worldwide. This study observes the influence of traditional Chinese medicine acupuncture and moxibustion on nutritional status and Cancer-Related Fatigue (CRF) in post-surgical LC patients, thus providing new references for the future treatment of LC. Materials and Methods: 94 LC patients admitted from March 2021 to May 2023 were selected as the research participants for a Acupuncture and moxibustion, Cancer-related fatigue, Immune function, Lung, carcinoma, Nutritional Status, Xiao chaihu Tang https://www.ijper.org/formulation-optimization-and-characterization-of-pongamia-pinnata-phytosomes-for 2026-04-13T05:54:02.327672+00:00 Formulation, Optimization and Characterization of Pongamia pinnata Phytosomes for Therapeutic Potential 2025-05-09 10.5530/ijper.20250544 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-949.pdf Background: Phytosomes are complex structures formed by the combination of natural phospholipids with phytoconstituents. The purpose could be to enhance the bioavailability of active compounds, such as flavonoids and polyphenols present in Pongamia pinnata by forming phytosomes, thus improving their absorption and efficacy. Materials and Methods: The preparation process was optimized by Box Behnken design to attain desirable particle size and encapsulation efficiency. Independent variables inclu Antidiabetic effect, Box Behnken design, Phytosomes, Pongamia pinnata https://www.ijper.org/design-and-characterization-of-dapsone-nanoemulgel-for-treatment-of-acne-vulgari 2026-04-13T05:54:02.327672+00:00 Design and Characterization of Dapsone Nanoemulgel for Treatment of Acne Vulgaris 2025-05-09 10.5530/ijper.20250457 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-923.pdf Background: Acne vulgaris is a disorder related to the skin (pilosebaceous), which is mainly caused by the formation of seborrhea, comedones, etc. It mainly affects the face, back, head and oil glands. In spite of the potent antimicrobial, anti-inflammatory and antibacterial potential of Dapsone (DPS), it has hurdles like poor water solubility and bioavailability. The objective of current research is to design, optimize and characterize Dapsone Emulgel (DPSE) for the treatment of acne vulgaris. Acne vulgaris, Dapsone, Emulgel, Zeta Potential, Antibacterial assay, P. acne etc https://www.ijper.org/recent-advances-in-smart-hydrogel-for-drug-delivery-in-cancer-therapeutics 2026-04-13T05:54:02.327672+00:00 Recent Advances in Smart Hydrogel for Drug Delivery in Cancer Therapeutics 2025-05-09 10.5530/ijper.20250454 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-854.pdf Cancer has been listed as the world's second-leading cause of death. Even with the significant progress made in recent years, advanced stages of the disease are still incurable. Conventional treatment options, such as surgery, chemotherapy and radiotherapy, have several inherent drawbacks that result in severe side effects and poor therapeutic efficacy. These drawbacks include their limited applicability, low bioavailability, multidrug resistance and high recurrence. Three-dimensional networks o Cancer therapeutics, Hydrogel, Smart hydrogel, Stimuli-responsive hydrogel https://www.ijper.org/trigonelline-attenuates-obstruction-induced-jaundice-in-experimental-rats-by-inh 2026-04-13T05:54:02.327672+00:00 Trigonelline Attenuates Obstruction-Induced Jaundice in Experimental Rats by Inhibiting Α-SMA/TGF-Β/Smad-3 Expression 2025-05-09 10.5530/ijper.20251127 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1032.pdf Background and Objectives: Obstructive jaundice is characterized by excessive accumulation of bilirubin due to blockage of bile ducts. Chronic obstruction can result in various complications. Trigonelline, a plant alkaloid derived from fenugreek seeds, has been extensively studied for its hepatoprotective effects. This study aimed to investigate the putative mechanism of action of trigonelline in an experimental model of obstructive jaundice. Materials and Methods: Obstructive jaundice was induc Collagen-1, Obstructive jaundice, Smad-3, TGF-β, Trigonelline, α-SMA https://www.ijper.org/calycosin-inhibits-cell-proliferation-and-induces-apoptosis-in-bladder-cancer-t2 2026-04-13T05:54:02.327672+00:00 Calycosin Inhibits Cell Proliferation and Induces Apoptosis in Bladder Cancer T24 Cells 2025-05-09 10.5530/ijper.20251188 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1144.pdf Aim/Background: Calycosin is a primary glycoside derived from the Chinese medicinal plant Radix astragali (RA). The compound has been demonstrated to suppress cell growth and trigger programmed apoptosis in various cancer cell lines. The current investigation was aimed to examine the impact of Calycosin on the proliferation and death of the bladder cancer cell line and its underlying mechanism. Materials and Methods: The present work aimed to investigate the effects of Calycosin on the rate of c Apoptosis, Bladder Cancer, Calycosin, Cell Proliferation, Oxidative Stress https://www.ijper.org/koenigicine-a-carbazole-alkaloid-mitigates-type-2-inflammation-and-alleviates-as 2026-04-13T05:54:02.327672+00:00 Koenigicine, a Carbazole Alkaloid, Mitigates Type 2 Inflammation and Alleviates Asthma in Animal and Cell Models 2025-05-09 10.5530/ijper.20251139 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1042.pdf Background: Allergic asthma is a global epidemic that significantly impacts the quality of life for both adults and children. Inhaled corticosteroids are regarded as the primary treatment for asthma, effectively alleviating symptoms over the long term; however, they do not adequately address Type 2 inflammation, which can exacerbate the condition. Therefore, we sought to evaluate the efficacy of koenigicine, a carbazole alkaloid, in mitigating Type 2 inflammation using both an ovalbumin-sensitiz Allergic Asthma, Anti-asthmatic drug, LPS stimulation, Ovalbumin sensitization, Type, 2 inflammation, Koenigicine https://www.ijper.org/development-of-gastro-retentive-combination-formulation-of-montelukast-sodium-an 2026-04-13T05:54:02.327672+00:00 Development of Gastro-Retentive Combination Formulation of Montelukast Sodium and Bepotastine Besilate for Allergic Rhinitis and Asthma 2025-05-09 10.5530/ijper.20250933 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-960.pdf Aim: The study aimed to develop a once-daily sustained-release gastroretentive combination formulation of bepotastine besilate and montelukast sodium using multilayer tablet technology and gastro-retentive systems for the treatment of allergic rhinitis and asthma. Background: Bepotastine besilate and montelukast sodium are commonly used to manage allergic rhinitis and asthma. However, their conventional formulations often require multiple doses per day, leading to poor patient compliance. A gast Combination Formulation, Floating, Gastro-Retentive, Similarity factor https://www.ijper.org/effects-of-puerarin-on-blood-fluoride-micro-ct-parameters-and-bone-histomorpholo 2026-04-13T05:54:02.327672+00:00 Effects of Puerarin on Blood Fluoride, Micro-CT Parameters and Bone Histomorphology in Rats with Fluorosis 2025-05-09 10.5530/ijper.20254530 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1137.pdf Aim: This study aims to examine the effects of puerarin on blood fluoride, micro-Computed Tomography (micro-CT) parameters and bone histomorphology of rats with fluorosis and to investigate whether puerarin has therapeutic effects on skeletal fluorosis. Materials and Methods: The 72 rats were randomly divided into the blank control group, model group and puerarin group. All the rats will be administered different doses of drug interventions. Morphological structure of bone tissue was observed by Puerarin, Fluorosis, Blood fluoride, Micro-CT parameters, Bone histomorphology https://www.ijper.org/the-novel-anti-inflammatory-mechanism-of-calcitriol-in-recurrent-spontaneous-abo 2026-04-13T05:54:02.327672+00:00 The Novel Anti-Inflammatory Mechanism of Calcitriol in Recurrent Spontaneous Abortion in Experimental Mice 2025-05-09 10.5530/ijper.20250634 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1170.pdf Background: In many instances, Recurrent Spontaneous Abortion (RSA) has unexplained etiology and does not have any prognostic clues. Antioxidant vitamins are closely related to a series of diseases, including RSA. However, the function and underlying mechanism of calcitriol in the treatment of RSA has not been described. Materials and Methods: The pregnant mice were injected intraperitoneally with Lipopolysaccharide (LPS) to induce abortion. Calcitriol was used for the treatment and to avoid RSA Anti-Inflammatory, Macrophages, NF-κB tab, Nrf2, Spontaneous Abortion https://www.ijper.org/design-and-characterization-of-letrozole-ethosomes-for-improved-topical-treatmen 2026-04-13T05:54:02.327672+00:00 Design and Characterization of Letrozole Ethosomes for Improved Topical Treatment of Breast Cancer 2025-05-09 10.5530/ijper.20250630 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-970.pdf Background: Breast cancer is the leading and most frequent cancer among women worldwide, with rapidly growing new cases diagnosed, surpassing lung cancer. The current study aims to design, optimize and characterize Letrozole (LTZ) Loaded Ethosomes (LTZ-ETH) for the treatment of breast cancer. Materials and Methods: Ethosomes were optimized using a two-factor, three-level (32) factorial design technique. The ethosomes were characterized by vesicle size, zeta potential and entrapment efficiency. T Apoptosis, Breast Cancer, Ethosomes, Factorial Design, Letrozole, Optimization https://www.ijper.org/neuroprotective-effect-of-porelis-a-standardized-extract-of-purple-tea-camellia 2026-04-13T05:54:02.327672+00:00 Neuroprotective Effect of Porelis, A Standardized Extract of Purple Tea (Camellia sinensis) Comprised of GHG in a 6-OHDA Induced Cellular Model of Parkinson’s Disease 2025-05-09 10.5530/ijper.20250594 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1053.pdf Introduction: Camellia sinensis is the most frequent used plant source for making tea, which are categorized as green, white, yellow, oolong, black and dark, among them, purple tea is a new variant of green tea developed in Kenya, it is believed that purple tea has greater health advantages than green tea because of its unique composition, which includes significant concentrations of anthocyanins and anthocyanidins. Objectives: This study aimed to evaluate the protective effect of Porelis, a sta Antioxidative enzymes, Apoptosis, Neurodegenerative disease, Neuroinflammation, Standardized extract https://www.ijper.org/development-and-validation-of-tofacitinib-citrate-in-api-and-tablet-formulation 2026-04-13T05:54:02.327672+00:00 Development and Validation of Tofacitinib Citrate in API and Tablet Formulation by UV Spectroscopic and HPTLC Method 2025-05-09 10.5530/ijper.20250546 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1187.pdf Introduction: In the present study, quantification of tofacitinib citrate by UV spectroscopy and HPTLC method were done and validated as per ICH guidelines. Tofacitinib was approved in 2012, it was first JAK inhibitor for the treatment of moderate to severe rheumatoid arthritis. In the UV spectroscopic method tofacitinib citrate was quantified at 287 nm using methanol as a diluent. In HPTLC method, toluene: methanol: acetic acid (7.5:2:0.5% v/v/v) were used as a mobile phase and an HPTLC silica UV spectroscopy, HPTLC method, Tofacitinib citrate, Tablet formulation https://www.ijper.org/investigation-on-the-effect-of-alginate-concentration-and-flow-rate-on-productio 2026-04-13T05:54:02.327672+00:00 Investigation on the Effect of Alginate Concentration and Flow Rate on Production of Nanoparticle Loaded with Naringenin Using Electrospray Method 2025-05-09 10.5530/ijper.20256682 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-995.pdf Background: Naringenin, a polyphenolic phytochemical belonging to the flavanone class, exhibits notable anti-cancer, antioxidant, and anti-inflammatory properties. However, its therapeutic application is constrained by poor aqueous solubility and limited delivery to target sites. Purpose: This study aimed to address these challenges by encapsulating naringenin in alginate nanoparticles using an electrospray method. The effects of varying alginate concentrations and flow rates on nanoparticle pro Alginate, Electrospray, Encapsulation, Flow Rate, Nanoparticle, Naringenin https://www.ijper.org/synthesis-and-in-vitro-evaluation-of-zinc-ferrite-nanospheres-for-sustained-carv 2026-04-13T05:54:02.327672+00:00 Synthesis and in vitro Evaluation of Zinc Ferrite Nanospheres for Sustained Carvedilol Drug Delivery 2025-05-09 10.5530/ijper.20251251 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1151.pdf Background: Magnetic nanoparticles has significant applications, in MRI contrast enhancement, tissue regeneration, cancer therapy, controlled drug delivery etc. The nanoparticles can be tailored to possess specific attributes suitable for distinct biological applications, as a potential drug carriers for sustained drug release. Materials and Methods: The present study focused on synthesizing and utilizing magnetic mesoporous Zn-Ferrite Nanospheres (Zn-Fe NSs) as carriers for controlled drug rele Drug delivery, Magnetic nanoparticles, Nanocarrier, Sustained drug release https://www.ijper.org/antidiabetic-activity-of-eupatorin-against-streptozotocin-induced-diabetes-in-ra 2026-04-13T05:54:02.327672+00:00 Antidiabetic Activity of Eupatorin against Streptozotocin-Induced Diabetes in Rats: Biochemical and Histological Studies 2025-05-09 10.5530/ijper.20251812 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1160.pdf Background: Diabetes mellitus is a persistent metabolic condition that has emerged as a major public health issue globally. The prevalence of diabetes has been rapidly increasing, posing a major challenge to global healthcare systems. Objectives: The present work was aimed at investigating the anti-diabetic roles of the eupatorin against Streptozotocin (STZ)-induced rat model. Materials and Methods: The rats received 55 mg/kg of STZ to induce diabetes and were then treated with eupatorin for 15 Alkaline phosphatase, Eupatorin, Hyperglycemia, Oxidative stress, Triglycerides, Urea https://www.ijper.org/medication-adherence-of-dpp-4-inhibitors-in-type-2-diabetic-management-a-hill-bo 2026-04-13T05:54:02.327672+00:00 Medication Adherence of DPP-4 Inhibitors in Type 2 Diabetic Management: A Hill Bone Medication Adherence Scale Analysis 2025-05-09 10.5530/ijper.20255148 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1231.pdf Background: The management of diabetes is a global health challenge. Non-adherence to medication in chronic diabetics is a severe issue that is linked to negative consequences, which can be related to various factors. The present study aims to evaluate the proportion of adherence to DPP-4 inhibitors with other Oral Hypoglycemic Agents (OHA) in type 2 diabetic management using hill bone medication adherence scale analysis. Materials and Methods: In this prospective interventional study, out of 10 Gliptin, Non-adherence, Hill-Bone scale, Medication adherence, Type 2 diabetic, patients https://www.ijper.org/monotropein-attenuates-nuclear-factor-kappa-b-activity-there-by-ameliorates-myco 2026-04-13T05:54:02.327672+00:00 Monotropein Attenuates Nuclear Factor Kappa B Activity there by Ameliorates Mycoplasma pneumoniae Triggered Pneumonia in Rodent Model 2025-05-09 10.5530/ijper.20251173 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1100.pdf Background: Pneumonia is a prevalent acute respiratory illness that impacts the alveoli and the distal airways and if left untreated, it presents a significant health challenge. It is linked to elevated rates of illness and death across all age groups worldwide. The treatment of pneumonia has become increasingly difficult due to antibiotic resistance, which complicates management strategies and leads to poorer patient outcomes. The rise of multi-drug resistant pathogens requires the use of stron Bacterial Pneumonia, Inflammation, Monotropein, Mycoplasma pneumoniae, NFkB, Phytochemical Drug https://www.ijper.org/elucidating-production-bottlenecks-in-the-indian-pharmaceutical-industry-for-enh 2026-04-13T05:54:02.327672+00:00 Elucidating Production Bottlenecks in the Indian Pharmaceutical Industry for Enhanced Pandemic Preparedness Using a Combined Theory of Constraints and Six Sigma Approach 2025-05-09 10.5530/ijper.20255228 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1204.pdf Aim/Background: Early in the COVID-19 epidemic, the dire need for effective and readily available outpatient therapies became apparent as healthcare systems worldwide faced unprecedented strain. This study addressed the initial focus on medications with anecdotal evidence against COVID-19 and the emergence of Hydroxychloroquine (HCQ) as a potential therapeutic option due to its demonstrated in vitro activity and established safety record in treating autoimmune conditions. However, the surge in p COVID-19, Pharmaceutical supply chain, Production bottlenecks, Six sigma, Theory of, constraints https://www.ijper.org/drug-repurposing-revealed-abemaciclib-and-palbociclib-as-inhibitor-of-phosphodie 2026-04-13T05:54:02.327672+00:00 Drug Repurposing Revealed Abemaciclib and Palbociclib as Inhibitor of Phosphodiesterase-5 (PDE5) in Cancer-Associated Fibroblasts Paving the Way for the Treatment of Breast Cancer 2025-05-09 10.5530/ijper.20251022 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1221.pdf Background: A common element of the tumor microenvironment, cancer-associated fibroblasts play a major role in the development of breast cancer via a variety of pathways. Studies show that cancer-associated fibroblasts over express phosphodiesterase-5 in comparison to normal fibroblasts and that this overexpression is linked to increased fibroblast activation and a more aggressive CAF phenotype. High PDE5 levels in CAFs contribute to the remodeling of the extracellular matrix, increased secretio Breast cancer, Cancer-associated fibroblasts, CDK4/6 inhibitors, Inhibitor, Phosphodiesterase-5 (PDE5) https://www.ijper.org/analysis-of-the-mechanism-of-action-of-atractylodes-macrocephala-koidz-polysacch 2026-04-13T05:54:02.327672+00:00 Analysis of the Mechanism of Action of Atractylodes macrocephala Koidz Polysaccharide on Breast Cancer-Related Depression Based on the TLR4/MyD88/ NF-κB Signaling Pathway 2025-05-09 10.5530/ijper.20251152 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1059.pdf Objectives: In the study, we analyzed the effect of Atractylodes macrocephala Koidz Polysaccharide (AMKP) on Breast Cancer-Related Depression (BCRD) to provide new references for future treatment of BCRD. Materials and Methods: First, after the liver toxicity test to determine the concentration of AMKP, we established a mouse model of BCRD and divided it into model, fluoxetine and AMKP groups treated with saline, fluoxetine and AMKP gavage, respectively. In addition, a group of normal control mi Atractylodes macrocephala Koidz Polysaccharide, Breast cancer-related depression, Immune function, Neurological function, TLR4/MyD88/NF-κB https://www.ijper.org/caspase-activation-upregulation-of-bax-and-p53-downregulation-of-bcl-2-and-enhan 2026-04-13T05:54:02.327672+00:00 Caspase Activation, Upregulation of Bax and P53, Downregulation of Bcl-2 and Enhanced Generation of Reactive Oxygen Species Mediate the Anti-proliferative and Anti-migratory Activity of Mefenamic Acid in Breast Cancer Cells 2025-05-09 10.5530/ijper.20250489 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1109.pdf Background: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are among the most prescribed pharmaceuticals worldwide. Similar to other NSAIDs, mefenamic acid possesses anti- inflammatory, analgesic and antipyretic properties. The present study was carried out to further elucidate the antiproliferative activity of mefenamic acid at the molecular level in the human breast cancer cell line (MCF-7). Materials and Methods: The cytotoxic effect of mefenamic acid on breast cancer cells (MCF-7) was assess Antimigratory, Antiproliferative, Breast cancer cells, Cytotoxicity, Gene expression, Mefenamic acid https://www.ijper.org/lutein-and-zeaxanthin-complex-51-protects-pigmented-epithelium-cells-and-photore 2026-04-13T05:54:02.327672+00:00 Lutein and Zeaxanthin Complex 5:1 Protects Pigmented Epithelium Cells and Photoreceptors in the Retina from A2E-Mediated Phototoxicity: An in vitro Study 2025-05-09 10.5530/ijper.20251039 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1085.pdf Background: The aging process of RPE (Retinal Pigment Epithelium cells) and the effects of blue light are caused by a high level of oxidative stress, which makes these cells susceptible to malfunctioning, cellular senescence and cell death. The accumulation of toxic byproducts of the visual pigment cycle, Bis-retinoid N-retinyl-N-retinylidene Ethanolamine (A2E), in the RPE is a major cause of visual impairment in the blue light effect. Degeneration of the retinal pigment epithelium and related p A2E (Bis-retinoid N-retinyl-N-retinylidene ethanolamine), Blue light effect, Lutein and, Zeaxanthin Complex 5:1 https://www.ijper.org/evaluating-the-validity-and-reliability-of-the-reflective-practice-questionnaire 2026-04-13T05:54:02.327672+00:00 Evaluating the Validity and Reliability of the Reflective Practice Questionnaire for Assessing Reflective Capacity among Medical Students in Central India 2025-05-09 10.5530/ijper.20255720 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-875.pdf Background: Reflection or metacognition can be described as the process of contemplating one's own thinking. It facilitates the cultivation of profound learning and critical thinking skills. Reflective Practice Questionnaire (RPQ) validation study has been conducted among Medical Students studying in American University. Its validity and reliability has not been sufficiently tested among Indian medical students so far. This study aimed to assess the validity, reliability, and factor loadings of Reflective Practice Questionnaire, Validity, Reliability, Factor loadings, Reflection, Medical students https://www.ijper.org/cardio-protective-effect-of-malvidin-against-doxorubicin-stimulated-cardiotoxici 2026-04-13T05:54:02.327672+00:00 Cardio-Protective Effect of Malvidin against Doxorubicin-Stimulated Cardiotoxicity in Experimental Rat Models 2025-05-09 10.5530/ijper.20250957 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-3-1016.pdf Background: Malvidin (MAL) is an anthocyanidin having therapeutic characteristics that provide several therapeutic advantages. Doxorubicin (DOX) is a valuable anti-tumor drug with a wider anticancer range; nevertheless, DOX's cardiotoxic side effects via oxidative stress and apoptosis restrict its clinical use. There are various old and modern solutions that can aid with this predicament. Even decades after the drug's side effects were revealed, no successful strategy for managing this clinical Anti-inflammatory, Cardiotoxicity, Doxorubicin, Malvidin, Oxidative stress https://www.ijper.org/formulation-and-evaluation-of-chronotherapeutic-delivery-of-sacubitril-valsartan 2026-04-25T06:30:17.891057+00:00 Formulation and Evaluation of Chronotherapeutic Delivery of Sacubitril Valsartan for Management of Hypertension 2025-04-23 10.5530/ijper.20254583 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-473.pdf **Introduction::** Early morning surge in blood pressure is a major cause of sudden cardiac arrest. **Objectives::** Development and evaluation of chronomodulated Compression Coated Tablets (CCT) for bedtime dosing of sacubitril-valsartan for the management of cardiac arrest. **Materialsand Methods::** The tablets contain fast disintegrating inner core of sacubitril-valsartan coated by compression coating technique with a hydrophilic polymer. Various ratios of HPMC K100M were used as coating p Sacubitril-valsartan, HPMCK100M, lactose, Compression coating, Chronotherapeutic drug delivery, Bedtime dosing https://www.ijper.org/preparation-and-evaluation-of-exosomes-loaded-with-combined-drugs-against-colon 2026-04-25T06:31:57.404366+00:00 Preparation and Evaluation of Exosomes Loaded with Combined Drugs against Colon Cancer 2025-04-23 10.5530/ijper.20250014 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-572.pdf **Background::** Nanoscale delivery systems such as milk exosomes, promising carriers for drug delivery, are used to deliver therapeutic drug molecules to the targeted organs. They possess characteristics that include low immunogenicity, specificity, and high bioavailability of cancer drugs. This research study unfolds the influence of the combination of phytoconstituents such as quercetin with an anticancer agent 5-fluoro uracil against the colon cancer cells HCT 116 and epithelial cells NCM 46 Exosomes, 5 Fluoro Uracil, Quercetin, Drug loading, MTT assay https://www.ijper.org/antidepressant-like-effect-of-ethanolic-leaves-extract-of-anthocephalus-cadamba 2026-04-25T06:34:18.086446+00:00 Antidepressant-Like Effect of Ethanolic Leaves Extract of Anthocephalus cadamba in CUMS Model of Depression in Swiss Albino Mice 2025-04-23 10.5530/ijper.20255377 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-594.pdf **Background::** Anthocephalus cadamba owe their family name to runiaceae. The plant's primary constituents include triterpenes, glycosides, saponins, flavonoids and indole alkaloids, including isocadambine, cadambine and isodihydrocadambine, cadamine. Literature survey reveals reports on pharmacological effects of anti-inflammatory, antioxidant, cytotoxic, antigenotoxic, sedative and antiepileptic, anticonvulsant activity, anti-cancer, Anti-helminthic activity and antimicrobial, Antifungal acti Depression, Serotonin, Antioxidant, Tail suspension test, Neuroprotective effect https://www.ijper.org/optimized-vildagliptin-microsphere-formulation-and-in-vitro-characterization-usi 2026-04-25T06:22:42.869437+00:00 Optimized Vildagliptin Microsphere Formulation and in vitro Characterization Using 23 Factorial Design Analysis 2025-04-23 10.5530/ijper.20250227 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-433.pdf **Background::** Vildagliptin is a dipeptidyl peptidase-4 inhibitor employed for the intervention of non-insulin-dependent diabetes mellitus which has a short half-life. The intention of this work is to devise and qualify vildagliptin microspheres to analyse the impact of two different-polymers, encapsulating agents, and stirring speeds for sustained drug release. **Materials and Methods::** The formulations were crafted by method of solvent evaporation and developed by applying 23 complete fac Vildagliptin, Microsphere, Solvent evaporation, Response surface https://www.ijper.org/role-of-brain-ang-1-7-with-combination-therapy-of-aliskerin-in-control-of-diabet 2026-04-25T06:35:29.148732+00:00 Role of Brain Ang (1-7) With Combination Therapy of Aliskerin in Control of Diabetic Nephropathy 2025-04-23 10.5530/ijper.20255883 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-633.pdf **Objectives::** Angiotensin (1-7) system has been recognizing as physiologically major content of the renin-angiotensin system. It exhibited that Diabetic Nephropathy (DN), which is prevalent causes of end-stage renal disease, reduces Ang (1-7) peripheral activity. RAS activity in the PNS is controlled by RAS in the brain. The goal of this research is to see whether cerebral angiotensin (1-7) has a role in chronic diabetic kidney disease in wistar rats. **Methods and Materials::** Single dosag Angiotensin (1-7), Diabetic nephropathy, End-Stage Renal Disease (ESRD), Aliskerin, Peripheral activity, Renin angiotensin system https://www.ijper.org/design-development-and-characterization-of-losartan-pharmacosomes-encapsulated-i 2026-04-25T06:31:10.999498+00:00 Design, Development and Characterization of Losartan Pharmacosomes Encapsulated in Capsule Formulation 2025-04-23 10.5530/ijper.20255974 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-523.pdf **Background::** In comparison to conventional vesicular drug delivery techniques, Pharmacosomes are a potential method for vesicular drug delivery that offers a number of advantages. Pharmacosomes are phosphilipid complexes with the potential to increase the bioavailability of medicines that are poorly lipophilic and poorly water soluble. Angiotensin receptor blocker losartan is classified as a BCS class II medication with low solubility. **Materials and Methods::** Solvent evaporation method Pharmacosomes, Losartan, Capsules, Solubility, Bioavailability https://www.ijper.org/development-and-validation-of-a-hplc-pda-method-to-quantification-of-ketobemidon 2026-04-25T06:37:08.993651+00:00 Development and Validation of a HPLC-PDA Method to Quantification of Ketobemidone in Rat Plasma and its’ Application in Pharmacokinetic Study 2025-04-23 10.5530/ijper.20256924 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-740.pdf **Aim::** Ketobemidone is an opioid drug that have been using against pain in various circumstances. The current research was aimed to develop and validate a HPLC-PDA method to estimate the ketobemidone in rat plasma. **Materials and Methods::** The ketobemidone in the biological matrices (rat plasma) was separated using solvent extraction method using methanol as extracting solvent. An isocratic mobile phase consisting of methanol-water-phosphate buffer at 40:60:0.01 % v/v/v and Kromasil C18 c Hematocrit, HPLC-PDA bioassay, Ketobemidone, Rat plasma, Validation https://www.ijper.org/optimizing-3d-structural-predictions-of-murine-2-adrenergic-receptor-swiss-model 2026-04-25T06:35:39.166982+00:00 Optimizing 3D Structural Predictions of Murine β2-Adrenergic Receptor: Swiss-Model Outperforms AlphaFolds 2025-04-23 10.5530/ijper.20256524 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-641.pdf **Background and Aim::** The 2 adrenergic receptor is vital in physiological processes and a key target for metabolic syndrome. Understanding the structural attributes of the murine 2-AR is crucial for comprehending metabolic regulation due to its close resemblance to the human 2-AR. Our study aimed to model the 3D structure of murine 2-AR using molecular simulation techniques to bridge gaps in structural understanding. **Materials and Methods::** In this study, we utilized in silico approaches β2 adrenergic receptors, Metabolic syndrome, AlphaFold, SWISS-MODEL, Computational modelling https://www.ijper.org/execution-of-quality-by-design-approach-in-the-formulation-of-fluconazole-inclus 2026-04-25T06:31:26.832083+00:00 Execution of Quality by Design Approach in the Formulation of Fluconazole Inclusion Complex Based Suppository for Vaginal Candidiasis 2025-04-23 10.5530/ijper.20256191 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-531.pdf **Aim::** The present work was carried out to improve the aqueous solubility of Fluconazole by formulation of inclusion complex using -cyclodextrin and then loaded into the suppository for the treatment of vaginal candidiasis. **Material and Methods::** Fluconazole (FOZ) Inclusion Complex (INC) with -Cyclodextrin (CD) was formulated first after optimization of the D-Optimal mixture design for the molar ratio. Then INC was prepared (1:1 molar ratio) with different methods (kneading, coprecipitat D-Optimal mixture design, Fluconazole, Inclusion complex, Solubility enhancement, Vaginal Candidiasis, β-cyclodextrin https://www.ijper.org/bioanalysis-and-validation-of-fesoterodine-an-antimuscarinic-agent-and-its-activ 2026-04-25T06:36:02.105488+00:00 Bioanalysis and Validation of Fesoterodine, an Antimuscarinic Agent and its Active Metabolite Using Liquid Chromatography with Tandem Mass Spectrometry 2025-04-23 10.5530/ijper.20250467 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-670.pdf **Aim::** To establish a bioanalytical method with rapid, specific and sensitiveness with tandem mass spectrometric with liquid chromatography for an antimuscuranic agent, fesoterodine and its metabolite, 5-hydroxy methyl tolterodine in plasma of human, using their isotopic labeled compounds correspondingly, with internal standards, fesoterodine d14 and 5-hydroxy methyl tolterodine d14. **Materials and Methods::** The extraction of analytes is by employing tert-butyl methyl ether, divided with 5-hmt, Antimuscuranic agent, Fesoterodine, Freeze thaw cycles, Human plasma, LC-MS/MS, Pharmacokinetic https://www.ijper.org/amelioration-of-diabetic-nephropathy-in-streptozotocin-induced-diabetic-rats-by 2026-04-25T06:33:51.429525+00:00 Amelioration of Diabetic Nephropathy in Streptozotocin-induced Diabetic Rats by Jasminum auriculatum vahl Leaves Extract 2025-04-23 10.5530/ijper.20254714 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-585.pdf **Background::** Considering the growing preference for herbal medications over their synthetic counterparts it is the need to combat the global end stage renal disease in Diabetic Nephropathy problem. In AYUSH medicine, the Jasminum auriculatum vahl tree is the one that is used. The Oleaceae family includes some of the most notable medicinal plants, including Jasminum auriculatum vahl, sometimes known as Juhi. **Aim and Objectives::** This study was designed to investigate the effect of Jasmin Diabetic nephropathy, End Stage Renal Disease, Jasminum auriculatum vahl, herbal medications, Streptozotocin (STZ) https://www.ijper.org/formulation-and-characterization-of-chitosan-based-oral-nanoparticles-of-poorly 2026-04-25T06:29:33.118835+00:00 Formulation and Characterization of Chitosan Based Oral Nanoparticles of Poorly Water-Soluble Drug Lurasidone Hydrochloride 2025-04-23 10.5530/ijper.20253872 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-454.pdf **Aim::** The purpose of research was to refine the solubility and dissolution assessment of lurasidone hydrochloride, a poorly water-soluble drug with a pH dependent solubility, by preparing chitosan-based nanoparticles using the ionic gelation process with sodium Tripolyphosphate (TPP) as a conjoin factor. **Background::** The poor water solubility and moderate oral bioavailability of antipsychotic medications provide a significant challenge in their oral distribution. The hydrophobic medicat Lurasidone HCl, Chitosan, Nanoparticles, Solubility https://www.ijper.org/formulation-and-evaluation-of-simvastatin-loaded-nanostructured-lipid-carrier-fo 2026-04-25T06:22:36.773831+00:00 Formulation and Evaluation of Simvastatin Loaded Nanostructured Lipid Carrier for Topical Drug Delivery 2025-04-23 10.5530/ijper.20250097 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-421.pdf **Introduction::** Simvastatin, a BCS II drug, has poor water solubility and low bioavailability. Nanostructured Lipid Carriers (NLCs) can enhance its bioavailability. This study investigates the potential of NLCs to improve simvastatin's bioavailability. **Objectives::** The primary objective was to enhance simvastatin's bioavailability by formulating it into NLCs using High-Speed Homogenization (HPH). The study also aimed to characterize the NLCs and evaluate their stability and irritation po Nanostructured Lipid Carrier, High-Speed Homogenization, Compritol 888 ATO https://www.ijper.org/method-development-for-estimation-of-azelnidipine-and-s-metoprolol-succinate-in 2026-04-25T06:36:10.816873+00:00 Method Development for Estimation of Azelnidipine and S (-) Metoprolol Succinate in Tablets by UV Spectrophotometry and HPLC Using Student’s T-Test 2025-04-23 10.5530/ijper.20253109 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-680.pdf **Introduction::** Azelnidipine a calcium channel blocker belongs to BCS class II and S (-) Metoprolol Succinate belongs to BCS class I. **Rationale::** Calcium is responsible for inducing smooth muscle contraction. Inhibiting calcium channel will inhibit the contraction of smooth muscles which results in reduction of blood pressure. Metoprolol selectively acts on -1adrenergic receptor (specifically related to cardiac cells). Metoprolol shows negative ionotropic and chronotropic effect. Thus, i Azelnidipine, Metoprolol, RP-HPLC, UV-Spectrophotometry https://www.ijper.org/advanced-solid-phase-extraction-tools-for-measuring-bempedoic-acid-and-its-activ 2026-04-25T06:37:44.328489+00:00 Advanced Solid Phase Extraction Tools for Measuring Bempedoic Acid and its Active Metabolite in Human Plasma by Using LC-MS/MS 2025-04-23 10.5530/ijper.20257284 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-758.pdf **Aim/Background::** To simultaneously measure bempedoic acid and its primary metabolite, bempedoic acid metabolite-ESP15228, in human plasma via UPLC-MS/MS, the QuEChERS extraction tactic is not suitable. Instead, employ a tailored bioanalytical approach. **Materialsand Methods::** The QuEChERS technique was employed to extract human plasma, followed by analysis using LC-MS/MS. Separation of compounds was attained using a Zorbax C18 analytical column (50 mm2.1 mm, 1.7 m), with retention times Bempedoic acid, Bempedoic acid metabolite, Bioanalytical, Plasma, QuEChERs https://www.ijper.org/spiked-human-plasma-samples-stability-indicating-method-development-and-validati 2026-04-25T06:37:32.139146+00:00 Spiked Human Plasma Samples: Stability Indicating Method Development and Validation of Pexidartinib by LCMS 2025-04-23 10.5530/ijper.20256947 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-748.pdf **Aim::** Pexidartinib (PDTB) was utilized in the development of a novel bioanalytical LCMS method in human plasma, with Talazoparib (TZPB) serving as the IS (Internal standard). **Materials andMethods::** The chromatographic separation was accomplished using an Xbridge C18 column (50 mM4.6 mM, 5 M) with an Acetonitrile-based simple isocratic mobile phase composition: Throughout the study, 0.6 mL/min of methanaol:0.1% orthophosphoric acid (35:35:30) was flow-regulated. **Results and Discussion Pexidartinib, Talazoparib, LC-MS, Bioanalytical method https://www.ijper.org/nanofibers-promising-novel-drug-delivery-technology-for-cosmeceuticals 2026-04-25T06:18:52.650432+00:00 Nanofibers: Promising Novel Drug Delivery Technology for Cosmeceuticals 2025-04-23 10.5530/ijper.20256017 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-397.pdf **Abstract:** Cosmeceuticals, a merger of cosmetics and pharmaceuticals, aim to deliver functional benefits beyond traditional cosmetics while still appealing to consumers. Because of advances in cosmetics, the quality of cosmetic goods used today has improved and their diversity has expanded, just as it has in every other business. The cosmetic industry has gained a new and innovative approach by integrating nanomaterials such as nanofibers, nanoparticles, Nano liposomes and Nano pigments into Acne, Cosmeceuticals, Electrospinning, Facial mask, Nanofiber, Wound dressing https://www.ijper.org/spectrophotometric-simultaneous-equation-and-area-under-the-curve-methods-for-es 2026-04-25T06:36:40.120746+00:00 Spectrophotometric Simultaneous Equation and Area under the Curve Methods for Estimation of Metoprolol Succinate and Telmisartan in Pure Drugs and its Combined Marketed Formulation 2025-04-23 10.5530/ijper.20255416 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-716.pdf **Background::** Telmisartan-metoprolol succinate formulations treat hypertension. The primary goal was to develop and evaluate a UV-spectrophotometric method for estimating telmisartan and metoprolol succinate in a combination tablet dosage form in accordance with ICH standards. **Aim::** The study aimed to develop a simple, swift, precise, accurate and cost-effective UV spectrophotometric method for the simultaneous estimation of Telmisartan (TEL) and Metoprolol succinate (MET) in a combined Ethanol, Hydrochloric acid, Metoprolol succinate, Simultaneous equation, Telmisartan, Validation https://www.ijper.org/a-qualitative-study-on-lecture-capturing-system-in-pharmacy-education-learners-p 2026-04-25T06:22:30.610675+00:00 A Qualitative Study on Lecture Capturing System in Pharmacy Education-Learners’ Perspective 2025-04-23 10.5530/ijper.20250352 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-417.pdf **Background::** The Lecture Capturing System method was implemented in Pharmacy education for a better understanding of the specific content and provides flexibility to review. This study observed pharmacy learners perspective on LCS impartus usage and its impact on the learning milieu. **Materials and Methods::** Non-probability (Convenient) sampling design was adopted and a qualitative study was carried out amongst 60 students in their third-year Pharmacy (B.Pharm) students from one of the p Learners, Lecture Capturing System, Pedagogy, Pharmacy education, Qualitative study https://www.ijper.org/a-doe-study-for-optimization-of-control-quality-attributes-and-critical-material 2026-04-25T06:30:30.822899+00:00 A DoE Study for Optimization of Control Quality Attributes and Critical Material Attributes in Development of Almotriptan Fast Dissolving Tablet for the Enhancement of Effective Surface Area 2025-04-23 10.5530/ijper.20255422 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-482.pdf **Background::** The primary goal of this study is to increase the effective surface area of Almotriptan and improve disintegration time and diffusion time of the tablet by using a direct compression technique for producing Fast-Dissolving Tablets (FDTs). **Materials and Methods::** As part of the Quality by Design (QbD) strategy, the Box Behnken Design (BBD) was used as the experimental design. Compression force (factor A), Polyplasdone XL 10 (factor B) and Explosol (factor C) are considered a Almotriptan, Compression force, Fast dissolving tablets, Box Behnken design and Quality by design https://www.ijper.org/quality-by-design-qbd-based-development-and-validation-of-rp-hplc-method-for-sim 2026-04-25T06:36:21.34396+00:00 Quality by Design (QbD) Based Development and Validation of RP-HPLC Method for Simultaneous Estimation of Metformin and Teneligliptin in Bulk and their Pharmaceutical Formulation 2025-04-23 10.5530/ijper.20253717 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-689.pdf **Aim::** To develop and validate simple, accurate, precise, sensitive and robust Reversed Phase High Performance Liquid Chromatographic (RP-HPLC) method for simultaneous estimation of metformin and teneligliptin in bulk and their pharmaceutical formulation by using Quality by Design (QbD) approach. **Materials and Methods::** The factor screening studies were performed using 2 level 4 factor (16 run) full factorial design. C18 Gracesmart column (1504.6 mm, 5 ) was saturated with mobile phase a Metformin, Teneligliptin, RP-HPLC, Quality by design (QbD) approach https://www.ijper.org/development-and-validation-of-uvvisible-spectrophotometric-method-for-estimation 2026-04-25T06:37:01.773534+00:00 Development and Validation of UV/visible Spectrophotometric Method for Estimation of Piroxicam from Bulk and Formulation 2025-04-23 10.5530/ijper.20256898 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-733.pdf **Background::** Piroxicam (PRX) is a potent anti-inflammatory medicine used both orally and topically to treat arthritis, gout, and other inflammatory disorders. Developing and testing an effective analytical technique is critical for quantitative estimations. **Materials and Methods::** This study provides a straightforward, exact, repeatable, accurate, and cost-effective UV-visible spectrophotometric method for quantifying PRX in bulk and formulation using Phosphate Buffer Saline (PBS) pH 7. PRX, UV/visible Spectrophotometry, Nanosuspension https://www.ijper.org/exploration-of-smart-utilization-of-biodegradable-nanobubbles-in-intensifying-th 2026-04-25T06:31:48.996728+00:00 Exploration of Smart Utilization of Biodegradable Nanobubbles in Intensifying the Capsaicin Bioavailability 2025-04-23 10.5530/ijper.20257237 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-560.pdf **Background::** Capsaicin (CAP), a naturally occurring alkaloid, shows many promising benefits but is unexplored due to its hydrophobic nature and limited bioavailability. **Objectives::** To address these limitations, the present study was focused on optimizing Polylactic acid co-Glycolic Acid (PLGA) nanobubbles as a sustained delivery system for capsaicin. Nanobubbles offer advantages such as enhanced solubility, stability, and bioavailability of capsaicin. **Materials and Methods::** CAP-P Box-Behnken design, Capsaicin, Nanobubbles, PLGA https://www.ijper.org/optimizing-loratadine-delivery-development-of-niosomal-transdermal-patches 2026-04-25T06:22:51.078985+00:00 Optimizing Loratadine Delivery: Development of Niosomal Transdermal Patches 2025-04-23 10.5530/ijper.20250564 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-443.pdf Objectives: To improve and optimize loratadine-loaded niosomal transdermal patches with a Box-Behnken Design to enhance drug delivery and evaluate their potential as an effective alternative to oral administration for allergy treatment. Materials and Methods: Span 40 and Span 80. A Box-Behnken Design (BBD) implemented in Design Expert software was employed to assess the impact of these surfactants on vesicle size, zeta potential and drug entrapment efficiency. Additional physicochemical properti Box-Behnken design, Entrapment efficiency, Loratadine-loaded niosomes, Niosomal, patches, Transdermal delivery https://www.ijper.org/box-behnken-design-unleashing-the-potential-of-desirability-function-for-enhance 2026-04-25T06:30:48.311096+00:00 Box Behnken Design: Unleashing the Potential of Desirability Function for Enhanced Permeability of Antidiabetic Nanoparticles 2025-04-23 10.5530/ijper.20255506 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-494.pdf **Aim::** The present study is focused to develop and optimize nanoparticulate delivery system for two antidiabetic drugs; Sitagliptin Phosphate (SP) and Empagliflozin (EMP) of BCS class III drugs as a single dosage form using Box Behnken Design (BBD) and desirability function in lieu of superior permeability. **Materials and Methods::** Nanoparticles (NPs) were prepared using natural polymer Chitosan (CS) by ion gelation technique. BBD was employed to attain optimized formulation via responses Box-Behnken design, Desirability function, Optimization, Chitosan-based nanoparticles, Sitagliptin phosphate, Empagliflozin https://www.ijper.org/efficient-fabrication-and-assessment-of-telmisartan-fast-dissolving-films-using 2026-04-25T06:30:07.299395+00:00 Efficient Fabrication and Assessment of Telmisartan Fast-Dissolving Films Using Solvent Casting Approach 2025-04-23 10.5530/ijper.20254097 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-464.pdf **Introduction::** Telmisartan (TLM) is a common angiotensin II receptor antagonist used to treat hypertension. However, the drug's limited bioavailability and delayed onset duration diminish its efficacy. To address these concerns, fast-dissolving TLM films were fabricated in this investigation using the solvent-casting method. **Objectives::** This investigation aimed to create a film formulation of TLM, a widely prescribed antihypertensive medication. The objectives were to optimize the form Fast dissolving film, Solvent casting Method, Pectin, PVP, TLM https://www.ijper.org/evaluation-of-in-vitro-anti-cancer-activity-of-vinorelbine-ditartrate-loaded-plg 2026-04-25T06:31:39.040824+00:00 Evaluation of in vitro Anti-Cancer Activity of Vinorelbine Ditartrate Loaded PLGA Chitosan Nanoparticles Using A549 Human Lung Cancer Cell Line 2025-04-23 10.5530/ijper.20256759 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-552.pdf **Background::** The purpose of this research was to determine if vinorelbine ditartrate Loaded PLGA Chitosan Nanoparticles have any anticancer effects when tested in vitro. Many different types of cancer may be effectively treated with vinorelbine. However, they have limited medical use due to undesirable side effects. To circumvent these unwanted impacts, a customized drug delivery method was developed, where we have synthesized and characterized vinorelbine ditartrate Loaded PLGA Chitosan Nan Cell apoptosis, Matrix Metalloproteinase, Reactive oxygen species, Sulphorodamine B, Vinorelbine Ditartrate https://www.ijper.org/microwave-assisted-synthesis-and-characterization-of-n-vinyl-2-pyrrolidone-graft 2026-04-25T06:35:50.074104+00:00 Microwave-Assisted Synthesis and Characterization of N-Vinyl-2-Pyrrolidone Grafted Almond Gum: A Natural Dietary Polysaccharide for Controlled Release of Diclofenac Sodium 2025-04-23 10.5530/ijper.20256712 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-656.pdf **Background::** Gums occurring in nature are widely used in pharmaceuticals for their unique properties and diversified applications. The natural gums are almost safely consumed as food additives as well as drug carriers, almond gum commonly known as Badam gum. It is inexpensive and endowed with a variety of beneficial traits such as antibacterial, antioxidant and emulsifier properties. Polymers are important in every individuals life, advancement in polymer sciences are helpful to improve thei Almond gum, Microwave assisted grafting, N-vinyl-2-pyrrolidone, Factorial design, Mucoadhesion, Diclofenac sustained release tablets https://www.ijper.org/bilosome-nanocarriers-for-enhanced-oral-bioavailability-and-cardiovascular-activ 2026-04-25T06:38:00.90381+00:00 Bilosome Nanocarriers for Enhanced Oral Bioavailability and Cardiovascular Activity of Milrinone 2025-04-23 10.5530/ijper.20250292 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-769.pdf **Background::** Cardiovascular Diseases (CVDs) are the main causes of death in both industrialized and developing nations, which are mostly brought on by poor lifestyles and insufficient physical activity. Recent years many novel approaches have been developed for effective drug delivery of cardiovascular drugs. Milrinone [MRN] is a cardiovascular medication that is mainly used in the intensive care unit and cardiac unit to provide cardiac support to patients suffering from acute heart failure. Milrinone, Bilosomes, Cardiovascular Disease, H9c2 Cells, Cellular Uptake Study https://www.ijper.org/casting-a-spotlight-on-factorial-design-exploring-the-power-of-doe-for-experimen 2026-04-25T06:22:16.936065+00:00 Casting a Spotlight on Factorial Design: Exploring the Power of DoE for Experiment Screening and Optimization: A Mini Review 2025-04-23 10.5530/ijper.20256017 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-406.pdf **ABSTRACT:** Design of Experiments (DOE) is a powerful and systematic approach used in various fields to efficiently plan, execute and analyze experiments. This review provides a comprehensive overview of the application of DOE in the context of screening and optimization of experiments. Screening experiments are employed to identify significant factors or variables that influence a response, while optimization experiments aim to fine-tune these factors to achieve optimal outcomes. The review i DoE (Design of Experiments), Experiment Screening, Factorial Design, Optimization, Plackett Burman design, Taguchi method https://www.ijper.org/qbd-enhanced-hplc-method-development-for-vildagliptin-and-metformin-hcl-formulat 2026-04-25T06:36:51.67544+00:00 QbD-Enhanced HPLC Method Development for Vildagliptin and Metformin HCl Formulations 2025-04-23 10.5530/ijper.20256263 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-724.pdf **Objectives::** This research employs the Quality by Design strategy to design an optimized High-Performance Liquid Chromatography method aimed at analyzing vildagliptin and metformin hydrochloride in pharmaceutical dosage forms. **Materials and Methods::** The mobile phases A and B comprised a buffer-acetonitrile mixture in ratios of 950:50 v/v and 600:400 v/v, respectively. Chromatographic separation was achieved using an YMC Triart C-18 column, with Vildagliptin detection conducted at 210 n HPLC method development, Metformin hydrochloride, Pharmaceutical dosage forms, Product understanding, Quality by Design, Risk management, Vildagliptin https://www.ijper.org/therapeutic-evaluation-of-camel-milk-derived-lactoferrin-for-in-vivo-anti-arthri 2026-04-25T06:35:16.63566+00:00 Therapeutic Evaluation of Camel Milk-Derived Lactoferrin for in vivo Anti-Arthritic Efficacy 2025-04-23 10.5530/ijper.20254695 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-626.pdf **Background::** Arthritis is a prevalent chronic inflammatory condition that significantly impacts individuals quality of life. Lactoferrin (Lf), a multifunctional glycoprotein found in CM, has shown promising anti-inflammatory and immunomodulatory properties. However, there is limited research on the anti-arthritic activity of Camel Milk (CM)-derived Lf. This study aims to evaluate the effectiveness of Lf isolated from CM in alleviating arthritis symptoms, providing valuable insights into its Lactoferrin, Camel milk, Monosodium urate crystals, Collagen type-II, Arthritis, Inflammation https://www.ijper.org/comparative-optimization-of-amylase-production-in-bacillus-velezensis-sp-using-r 2026-04-25T06:34:48.379612+00:00 Comparative Optimization of α-Amylase Production in Bacillus velezensis sp. Using Response Surface Methodology and Artificial Neural Networks 2025-04-23 10.5530/ijper.20254639 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-602.pdf **Background::** This study aims to optimize the production of -amylase from Bacillus velezensis sp. through a comparative analysis of advanced experimental methodologies, specifically Definitive Screening Design-Response Surface Methodology (DSD-RSM) and Artificial Neural Networks (ANN). The research emphasizes the use of environmentally sustainable and cost-effective agro-solid substrates, namely moong husk and soybean cake, to enhance enzyme yield, addressing the growing industrial demand for α-amylase, Artificial Neural Networks, Bacillus velezensis sp., Bioprocess Optimization, Definitive Screening Design, Response Surface Methodology https://www.ijper.org/nanostructured-lipid-carriers-based-gel-of-methotrexate-for-rheumatoid-arthritis 2026-04-25T06:30:58.341992+00:00 Nanostructured Lipid Carriers Based Gel of Methotrexate for Rheumatoid Arthritis: Development, Characterization and Optimization through Taguchi Design 2025-04-23 10.5530/ijper.20255540 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-508.pdf **Background::** The goal of this work was to develop, optimise and characterise nanostructured lipid carriers containing methotrexate for the treatment of Rheumatoid Arthritis (RA). As materials and process parameters, solid lipid, surfactant and stirring time were originally tested. The best alternative was chosen, and additional optimisation was performed using Taguchi orthogonal (L9) array design. **Materials and Methods::** Several batches of NLCs have been generated using the microemulsio Methotrexate, Nanostructured Lipid Carriers, Rheumatoid Arthritis, Taguchi design, Gel, Intra-articular carrageenan injection https://www.ijper.org/response-surface-methodology-as-a-tool-for-stability-indicating-method-developme 2026-04-25T06:36:29.336244+00:00 Response Surface Methodology as a Tool for Stability-Indicating Method Development and Validation for the Determination of Selective EZH2 Inhibitor 2025-04-23 10.5530/ijper.20254323 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2s-705.pdf **Background::** Tazemetostat (TZST) is an efficient first-in-class, selective, EZH2 oral inhibitor which had demonstrated tumor regression and favourable safety in patients with Epithelioid Sarcoma. Methods developed using Analytical Quality by Design (AQbD) are highly robust, cost effective, uses good experimental designs, have shorter run times, optimization can be done by statistical analysis and can be easily validated. **Objectives::** The objective of the present study was to use the Scr TZST, AQbD, CCD, RSM, Stability-indicating https://www.ijper.org/formulation-and-evaluation-of-lipid-nanogel-loaded-with-quercetin-and-curcumin-f 2026-04-13T05:54:04.322743+00:00 Formulation and Evaluation of Lipid Nanogel Loaded with Quercetin and Curcumin for Improvement of Topical Bioavailability 2025-03-06 10.5530/ijper.20250569 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-585.pdf **Aims:** The present work was aimed to develop and optimize the QCN and CRN-loaded combinatorial NLC (QC-NLC) gel through the Central Composite Rotatable Design (CCRD) for bioavailability improvement of QCN and CRN in the management of skin cancer after its topical application. **Materials and Methods:** After the compatibility study and selection of excipients, CCRD was run and thirteen formulae were obtained. Optimization was completed against particle size, PDI and entrapment efficiency. QC Combination therapy, Dermatokinetics, Design of experiment, Extrudability, Lipid nanocarrier. https://www.ijper.org/cardamonin-lowers-intraocular-pressure-and-inhibits-glaucoma-development-in-ster 2026-04-13T05:54:04.322743+00:00 Cardamonin Lowers Intraocular Pressure and Inhibits Glaucoma Development in Steroid-Induced Rats by Activation of Nrf-2/Ho-1 Pathway 2025-03-06 10.5530/ijper.20250444 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-695.pdf **Background:** Glaucoma, a progressive optic neuropathy characterized by optic nerve injury, is a pivotal cause of vision loss globally. Objective: The current work focuses on assessing the therapeutic role of cardamonin against experimentally-induced glaucoma in rats. **Materials and Methods:** The experimental glaucoma in rats was induced by betamethasone, and then cardamonin was treated at 25 and 50 mg/kg concentrations. The Intraocular Pressure (IOP) level was assessed on a weekly basis. T Glaucoma, Retinal Ganglial Cells, Nrf-2/HO-1 Pathway, Inflammation, 4-Hydroxynonenal. https://www.ijper.org/thymol-improves-brain-functional-outcomes-after-cerebral-ischemia-reperfusion-in 2026-04-13T05:54:04.322743+00:00 Thymol Improves Brain Functional Outcomes after Cerebral Ischemia-Reperfusion Injury by Regulating p38 MAPK Associated Apoptosis Signalling Pathway 2025-03-06 10.5530/ijper.20257027 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-790.pdf **Background:** Thymol, a monoterpene phenolic compound and an essential oil extracted from Tachyspermum ammi (ajwain) has been shown to possess multiple therapeutic potentials as anti-inflammatory, antioxidant, antihyperlipidemic, antiapoptotic, antitumor agent against neurological, cardiovascular, gastrointestinal and malignant diseases. **Objectives:** The current investigation aimed to determine whether thymol could protect rats from cerebral ischemia reperfusion injury by preventing Bilate Anti-inflammatory activity, p38 MAPK, Anti-apoptotic activity, Ischemic reperfusion injury, Thymol. https://www.ijper.org/application-of-network-pharmacology-computational-molecular-docking-and-experime 2026-04-13T05:54:04.322743+00:00 Application of Network Pharmacology, Computational Molecular Docking and Experimental Techniques to Study the Anticancer Effects of Ursolic Acid on Oral Squamous Carcinoma Cells 2025-03-06 10.5530/ijper.20250379 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-826.pdf **Background:** Oral Squamous Cell Carcinoma (OSCC) is a prevalent and aggressive form of cancer with limited effective therapeutic options. This study explores the potential anticancer effects of ursolic acid and its mechanism using a network pharmacology approach, in silico molecular docking and various experimental methods to validate these findings. **Materials and Methods:** Oral cancer genes were found using Genecards, Drugbank and Therapeutic Target Database. Swiss Target Prediction and Gene Ontology, Network pharmacology, In silico molecular docking, Apoptosis. https://www.ijper.org/internet-of-medical-things 2026-04-13T05:54:04.322743+00:00 Internet of Medical Things 2025-03-06 10.5530/ijper.20250981 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-849.pdf Quality healthcare has been universally recognized as a fundamental human right, but sadly, this right is not sufficiently fulfilled globally. The goal of healthcare 4.0 is to completely revolutionize the healthcare delivery system and part of its bigger framework includes the Internet of Medical Things, or IoMT. IoMT devices are changing patient care and the healthcare industry. IoMT is being used by a number of hospitals and clinics to run their healthcare IT systems more profitably and effici Healthcare 4.0, Internet of Medical Things, Internet of Things, Medical devices, Patient monitoring. https://www.ijper.org/eco-friendly-fabrication-of-sno2-curcumin-nanoparticles-via-pterocarpus-marsupiu 2026-04-13T05:54:04.322743+00:00 Eco-Friendly Fabrication of SnO2-Curcumin Nanoparticles via Pterocarpus marsupium Extract: Unveiling Potent Antimicrobial and Anticancer Applications 2025-03-06 10.5530/ijper.20257442 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-719.pdf **Background:** Curcumin-SnO2 Nanoparticles (NPs) are advanced materials that combine organic molecules and inorganic substances in a single nanoscale platform to create hybrids with unique and enhanced properties. The synergy between the two components often results in improved functionality, stability and efficacy. **Objectives:** The current work was conducted on Curcumin-SnO2 NPs synthesized using an eco-friendly method with Pterocarpus marsupium extract and evaluated their antimicrobial an Curcumin, Nanoparticles, Pterocarpus Marsupium, MDA-MB-231 cancer cells. https://www.ijper.org/development-and-characterization-of-paclitaxel-loaded-magnetic-nanoparticle-embe 2026-04-13T05:54:04.322743+00:00 Development and Characterization of Paclitaxel-Loaded Magnetic Nanoparticle-Embedded Transdermal Patches for Non-Invasive Breast Cancer Therapy 2025-03-06 10.5530/ijper.20251989 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-617.pdf **Background:** Breast cancer remains a significant health concern, necessitating the development of advanced drug delivery systems for improved therapeutic outcomes. This study focuses on the design and evaluation of non-invasive transdermal patches incorporating magnetic nanoparticles (MNPs) for targeted Paclitaxel (PTX) delivery. **Materials and Methods:** PTX-loaded MNPs were synthesized and characterized for particle size, zeta potential, drug loading capacity, and stability. The nanoparti Breast Cancer, Magnetic Nanoparticles, Paclitaxel, Transdermal Patches. https://www.ijper.org/isoliensinine-prevents-against-lipopolysaccharide-induced-rat-acute-lung-injury 2026-04-13T05:54:04.322743+00:00 Isoliensinine Prevents against Lipopolysaccharide-induced Rat Acute Lung Injury and Sepsis via Inhibiting the Inflammatory Mediators 2025-03-06 10.5530/ijper.20250460 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-783.pdf **Background:** Novel pharmaceuticals have been largely derived from natural substances. Through this experimental study, we sought to assess the impacts of Isoliensinine (ILS) on Acute Lung Injury (ALI) and sepsis caused by Lipopolysaccharide (LPS) in rats. **Materials and Methods:** The rats were assigned to 3 different groups: control, LPS-induced and LPS+ILS. ILS exhibits a wet/dry weight ratio was measured. Blood Serum AST, ALT, ALP and hsCRP levels were measured. Also, levels of oxidative Isoliensinine, Acute Lung Injury, Sepsis, Anti-Inflammatory, Lipopolysaccharide. https://www.ijper.org/investigating-the-anti-inflammatory-antioxidant-and-apoptotic-protein-inhibition 2026-04-13T05:54:04.322743+00:00 Investigating the Anti-Inflammatory, Antioxidant and Apoptotic Protein Inhibition Study of Berberine on Diabetic Retinopathy in Rats 2025-03-06 10.5530/ijper.20250344 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-647.pdf **Background:** Globally, Diabetic Retinopathy (DR) is a leading cause of vision loss. This disease, which impacts the microvasculature of the retina, is brought on by the oxidative stress linked to diabetes. Several studies have shown the anti-diabetic properties of the plant-derived phytochemical "Berberine". However, there is a limited amount of research available on its effects, specifically on Diabetic Retinopathy (DR). **Objectives:** The primary aim of the present investigation is to ass Diabetic retinopathy, Apoptosis, Anti-inflammatory, Alloxan, Cytokines, Antioxidant. https://www.ijper.org/investigating-the-dual-action-potential-of-z-6-methoxy-2-naphthalen-1-ylmethylen 2026-04-13T05:54:04.322743+00:00 Investigating the Dual-Action Potential of (Z)-6-methoxy 2-(naphthalen-1-ylmethylene) Benzofuran-3(2H)-one (AU-23): A Novel Synthetic Aurone Derivative with Antibacterial and Anti-Inflammatory Activ 2025-03-06 10.5530/ijper.20255518 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-810.pdf **Aim/Background:** Aurone is a well-known, naturally occurring, minor flavonoid with significant biological properties. However, their low abundance in nature limits their application in the medical field. In this study, we investigated the antimicrobial and anti-inflammatory properties of a novel synthetic aurone, (Z)-6-methoxy-2-(naphthalen-1-ylmethylene) benzofuran-3(2H)-one (AU-23). **Materials and Methods:** AU-23 was synthesized via multistep synthesis reactions involving the oxidative c Aurone, Antimicrobial activity, Antibiofilm activity, Anti-inflammatory activity, Docking study. https://www.ijper.org/assessing-the-cytotoxicity-and-wound-healing-potential-of-pranic-healing-colours 2026-04-13T05:54:04.322743+00:00 Assessing the Cytotoxicity and Wound Healing Potential of Pranic Healing Colours: An in vitro Study on HaCaT Cell Line 2025-03-06 10.5530/ijper.20250945 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-777.pdf **Background:** Pranic Healing is a complementary therapy that uses specific colours to enhance the healing of wounds. **Objectives:** Our research sought to investigate the impacts of integrating various Pranic Healing (PH) colours on wound healing. **Materials and Methods:** HaCaT cells were subjected to cytotoxicity and scratch assays. After wound formation, Pranic colours were projected to the cells individually or in combination. The data was collected at the 24th, 48th and 72nd hr. **Re Biofield, Complementary therapy, Prana, Wound healing, Yoga. https://www.ijper.org/antibacterial-activity-of-bacteriocin-like-inhibitory-substances-produced-by-lac 2026-04-13T05:54:04.322743+00:00 Antibacterial Activity of Bacteriocin-Like Inhibitory Substances Produced by Lactic Acid Bacteria Isolated from Cheese against Pathogens 2025-03-06 10.5530/ijper.20250239 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-738.pdf **Background:** Lactic Acid Bacteria (LAB) produce bacteriocins, which have recently attracted considerable interest as alternatives to antibiotics. Cheese, a fermented food rich in LAB, is highly perishable and susceptible to contamination by foodborne pathogens. **Objectives:** This study aims to assess the antibacterial properties of Bacteriocin-Like Inhibitory Substances (BLIS) from four LAB i.e. Lactobacillus fermentum strain NBRC15885 (L. fermentum), Lacticaseibacillus paracasei strain NB Lactic acid bacteria, Bacteriocins, Feta cheese, Antibacterial activity, Pathogens and Antibiotics. https://www.ijper.org/research-on-the-path-and-strategy-of-traditional-chinese-medicine-talent-cultiva 2026-04-13T05:54:04.322743+00:00 Research on the Path and Strategy of Traditional Chinese Medicine Talent Cultivation Based on Demand Orientation 2025-03-06 10.5530/ijper.20252630 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-712.pdf **Background:** Traditional Chinese Medicine (TCM) has shown unique advantages in the prevention and treatment of chronic complex diseases, emergency treatment and major infectious diseases, especially COVID-19 epidemic. Reformation and improvement of the talent cultivation mode with distinctive TCM characteristics is the approach to realize the high-quality development of TCM. **Materials and Methods:** This paper systematically analyzed the development process of TCM talent cultivation in the Traditional Chinese medicine, Talent cultivation, Postgraduate education, Cultivation path. https://www.ijper.org/network-pharmacology-based-modeling-of-phytocompounds-in-a-traditional-siddha-fo 2026-04-13T05:54:04.322743+00:00 Network Pharmacology-Based Modeling of Phytocompounds in a Traditional Siddha Formulation-Kabasura kudineer with Special Reference to SARS-CoV-2 2025-03-06 10.5530/ijper.20256024 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-682.pdf **Background:** Kabasurak kudineer (Kk), a traditional Siddha formulation containing 15 plant-based ingredients has been prescribed in Siddha medicine for the management and treatment of flu-like symptoms. Currently, the Ministry of AYUSH, Government of India has been prescribing Kk as a possible preventive and prophylactic formulation against COVID-19. Objectives: The present study focuses on computational methods and aims to identify host targets in different pathways where the phytocompounds COVID-19, Ellagic acid, Kabasurak kudineer, Molecular docking, Network Pharmacology. https://www.ijper.org/reforming-teaching-methods-for-pathology-courses-in-traditional-chinese-medicine 2026-04-13T05:54:04.322743+00:00 Reforming Teaching Methods for Pathology Courses in Traditional Chinese Medicine 2025-03-06 10.5530/ijper.20254830 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-530.pdf **Background:** New medical science policy of the Chinese Ministry of Education, a reform of the Traditional Chinese Medicine (TCM) teaching and training curriculum has been underway for some years. **Aim:** To assess whether the final examination results, questionnaire survey of generalpathology and TCM scores are related to traditional education. **Materials and Methods:** We selected the traditional teaching grades of 2016, 2017 and 2018 as our research objects and used statistical software New medical department, Pathology course, Reform ideas, Traditional Chinese Medicine, Western medical pathology. https://www.ijper.org/the-effect-of-kaempferol-on-cortical-nlrp3caspase-1gsdmd-mediated-cell-pyroptosi 2026-04-13T05:54:04.322743+00:00 The Effect of Kaempferol on Cortical Nlrp3/Caspase-1/Gsdmd Mediated Cell Pyroptosis in Chronic Epileptic Rats 2025-03-06 10.5530/ijper.20250368 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-673.pdf **Aim:** To study the Kaempferol (Kaem) on Pentetrazol (PTZ)-induced chronic epileptic rats, and to explore its effect on nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)/ caspase-1/gasdermin D (GSDMD)-mediated pyroptosis in the cerebral cortex and its possible mechanism. **Materials and Methods:** Six rats were randomly selected from 30 SPF male SD rats as the normal group, and the remaining rats were intraperitoneally injected with PTZ (35 mg/kg) for 28 d to replicate Epilepsy, Kaem, NLRP3/caspase-1/GSDMD signaling pathway, Pyroptosis. https://www.ijper.org/effectiveness-assessment-of-dapagliflozin-as-an-add-on-to-sitagliptin-vildaglipt 2026-04-13T05:54:04.322743+00:00 Effectiveness Assessment of Dapagliflozin as an Add on to Sitagliptin, Vildagliptin and Metformin in Patients with Different Demographic Parameters in Type II DM 2025-03-06 10.5530/ijper.20255779 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-544.pdf **Objectives:** The study's goal is to examine the efficacy of various newer anti-diabetic drug combinations that include SGLT2 inhibitors (dapagliflozin), DPP-4 inhibitors (sitagliptin and vildagliptin) and metformin. **Materials and Methods:** Patients with diabetes who had blood glucose levels that were managed (as per the established guidelines), as indicated by Fasting Blood Sugar (FBS) and Postprandial Blood Sugar (PPBS), met the inclusion criteria for this study. Only a person's medical Combination drug therapy, Dapagliflozin, Type II Diabetes, Glycemic control. https://www.ijper.org/multicomponent-system-a-novel-approach-in-cocrystal-techniques-for-improving-the 2026-04-13T05:54:04.322743+00:00 Multicomponent System: A Novel Approach in Cocrystal Techniques for Improving the Solubility of Poorly Soluble Drugs 2025-03-06 10.5530/ijper.20257037 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-504.pdf Poor solubility in modern pharmaceuticals has been a significant barrier to achieving optimal oral bioavailability. A majority of drug substances and New Chemical Entities (NCEs) are classified under BCS (Biopharmaceutical Classification System) Class II or Class IV. Cocrystals, which are multicomponent systems comprising an Active Pharmaceutical Ingredient (API) and one or more coformers in a specific stoichiometric ratio, have been utilized to address this issue. Furthermore, cocrystals and mu Cocrystals, Multicomponent Systems, Dissolution Enhancement, Improved, Physicochemical Properties https://www.ijper.org/fostering-ethical-decision-making-skills-in-pharmaceutical-education-vital-for-f 2026-04-13T05:54:04.322743+00:00 Fostering Ethical Decision-Making Skills in Pharmaceutical Education: Vital for Future Pharmacists 2025-03-06 10.5530/ijper.20254872 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-433.pdf Ethical decision-making is a fundamental aspect of pharmacy practice, as pharmacists often face complex moral dilemmas while providing patient care and dispensing medications. The incorporation of ethical training in pharmaceutical curricula is crucial to equip future pharmacists with the necessary skills to navigate these challenging situations responsibly. This paper explores the importance of integrating ethical decision-making training in pharmacy education and discusses the potential benefi Ethical decision-making, Pharmacy education, Ethical training, Curriculum development, Patient care, Pharmacy practice. https://www.ijper.org/pro-inflammatory-cytokines-predict-the-response-of-cancer-treatment 2026-04-13T05:54:04.322743+00:00 Pro-Inflammatory Cytokines Predict the Response of Cancer Treatment 2025-03-06 10.5530/ijper.20254089 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-441.pdf The immune condition has an important effect on cancer growth and progression at both the systemic and neoplastic microenvironment levels. Immune modulation or activation has clinical significance for prognostic and diagnostic purposes. Cytokines are signalling proteins that allow communication between cells and are essential for a functioning immune system. Innate and adaptive immune cells, as well as non-immune cells and tissues, communicate via cytokines. Understanding the body's reaction to Cancer, Cytokines, Immune System, Tumor Markers. https://www.ijper.org/antioxidant-skin-cleansing-moistening-and-foaming-characteristics-of-botanical-s 2026-04-13T05:54:04.322743+00:00 Antioxidant, Skin Cleansing, Moistening and Foaming Characteristics of Botanical Surfactant Saponins Extracted from Pu’er Tea (Black Tea) Seeds 2025-03-06 10.5530/ijper.20250139 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-639.pdf **Background:** Natural and sustainable trends around the world are an inevitable choice for the cosmetic industry, thus various ingredients including surfactants derived from renewable and sustainable sources are technically innovative cornerstones, compared with synthetic ones. Natural products and natural product-based agents have been known to play crucial roles in many industries including the cosmetic industry. **Aim:** The primary aim of the present research is to extract botanical-deriv Botanical Surfactant, BTS Saponins, Surface tension, Foam, Skin/Eye Safety, Antioxidant. https://www.ijper.org/research-on-improved-design-method-of-intelligent-pharmacy-based-on-kanoahpqfd-a 2026-04-13T05:54:04.322743+00:00 Research on Improved Design Method of Intelligent Pharmacy Based on KANO/AHP/QFD and FBS Modeling 2025-03-06 10.5530/ijper.20256761 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-550.pdf **Aim/Background:** The use of Intelligent pharmacy applications has grown increasingly popular in the field of intelligent healthcare. The objective of this study is to develop an Intelligent pharmacy that addresses the issues of user inconvenience and low satisfaction by meeting their specific requirements. At the same time, it offers a benchmark solution for an intelligent medication management system. **Materials and Methods:** This study employs the KANO model, AHP, QFD and FBS model to st Intelligent Pharmacy, KANO modelling, Analytic Hierarchy Process, Quality Function Deployment, Functional Behavior Structure, Improved Design. https://www.ijper.org/pennogenin-induces-apoptosis-in-colon-cancer-hct-116-cells-via-increasing-apopto 2026-04-13T05:54:04.322743+00:00 Pennogenin Induces Apoptosis in Colon Cancer HCT-116 Cells via Increasing Apoptotic Markers and Downregulating PI3K/AKT/mTOR Pathway 2025-03-06 10.5530/ijper.20250474 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-800.pdf **Background:** Colon cancer is the third major type of cancer globally and the second most reason for cancer-associated mortality. Natural products (phytochemicals) are considered safer alternatives to treat colon cancer. **Objectives:** In this work, we aimed at disclosing the anticancer activities of the pennogenin against the colon cancer cells. **Materials and Methods:** The antioxidant properties of pennogenin were investigated using numerous free radical scavenging tests, including DPPH PI3K/AKT/mTOR pathway, Pennogenin, Apoptosis, Cyclin D1, HCT-116 cells. https://www.ijper.org/quality-by-design-driven-hplc-method-development-for-quantification-of-resveratr 2026-04-13T05:54:04.322743+00:00 Quality by Design-Driven HPLC Method Development for Quantification of Resveratrol in Bulk and Pharmaceutical Dosage Form and its Validation 2025-03-06 10.5530/ijper.20254922 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-841.pdf **Background:** The purpose of the recent research was to establish a simple, efficient, sensitive and accurate High-Performance Liquid Chromatography (HPLC) method for estimating Resveratrol (RVT) in bulk and pharmaceutical dosage form based on Quality by Design (QbD). As risk assessment and statistics are not used in a conventional approach, the Analytical Quality by Design (AQbD) was employed with scientific techniques including Analytical Target Profile (ATP), Critical Quality Attributes (CQ Resveratrol, High-Performance Liquid Chromatography, Central Composite Design, Quality by Design, Validation. https://www.ijper.org/comparative-efficacy-of-cytokines-and-drugs-in-promoting-the-expansion-of-bone-m 2026-04-13T05:54:04.322743+00:00 Comparative Efficacy of Cytokines and Drugs in Promoting the Expansion of Bone Marrow-Derived Mesenchymal Stem Cells: A Systematic Review and Meta-Analysis 2025-03-06 10.5530/ijper.20251689 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-767.pdf **Aim/Background:** Bone Marrow (BM) Mesenchymal Stem Cells (MSCs) possess significant clinical potential, yet their limited expansion ability in the laboratory restricts their broad application. While cytokines and pharmaceuticals are commonly used strategies to promote BM-MSC expansion, a systematic comparison of their effects has not been conducted. This study aims to evaluate and compare the effects of cytokines and pharmaceutical agents on the proliferation and osteogenic differentiation of Bone Marrow-Derived Mesenchymal Stem Cells, Cytokines, Drugs, Proliferation, Osteogenic Differentiation, Systematic Review, Meta-Analysis https://www.ijper.org/an-albumin-glutaraldehyde-nanoparticle-loaded-with-berberine-inhibits-cell-growt 2026-04-13T05:54:04.322743+00:00 An Albumin-Glutaraldehyde Nanoparticle Loaded with Berberine Inhibits Cell Growth and Induces Apoptosis in Colon Cancer HCT-116 Cells 2025-03-06 10.5530/ijper.20257394 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-563.pdf **Background:** The study aims to synthesize and characterize berberine-loaded albumin-glutaraldehyde nanoparticles and evaluate their anticancer activity against colon cancer HCT-116 cells. The research focuses on the mechanisms involved in oxidative stress-dependent apoptosis, crucial for inhibiting colon cancer growth and promoting overall health. **Materials and Methods:** The synthesized Berberine-Albumin NPs were characterized using several techniques, including UV-visible spectroscopy, X Nanoparticles, Berberine, Albumin, Colon cancer, Oxidative stress, Apoptosis. https://www.ijper.org/design-and-characterization-of-microwave-irradiation-assisted-amorphous-solid-di 2026-04-13T05:54:04.322743+00:00 Design and Characterization of Microwave Irradiation Assisted Amorphous Solid Dispersion of Resveratrol 2025-03-06 10.5530/ijper.20255129 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-574.pdf **Background:** One of the emerging solutions for facing the solubility as well as dissolution issuesof poorly soluble drugs is formulation approach by dispersing drugs in hydrophilic carriers. **Objectives:** Present study aims in enhancing the solubility of resveratrol by amorphous soliddispersion technique. **Materials and Methods:** Solid dispersions were prepared by microwave irradiation where the irradiation time and the drug: carrier ratios were optimized using Design of Experiments by Microwave irradiation, Amorphous solid dispersion, Resveratrol, Soluplus, Design Expert, Solubility enhancement. https://www.ijper.org/identification-of-novel-drug-targets-and-potential-antibacterial-traditional-chi 2026-04-13T05:54:04.322743+00:00 Identification of Novel Drug Targets and Potential Antibacterial Traditional Chinese Medicine Compounds for Klebsiella pneumoniae through in silico and Antibacterial Activity Evaluation 2025-03-06 10.5530/ijper.20251069 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-655.pdf **Background:** Klebsiella pneumoniae is a ubiquitous opportunistic pathogen that poses a significant threat to hospitalized patients by causing a wide range of infections. The alarming increase in clinical resistance to all current antibiotics necessitates the urgent identification of novel therapeutic targets and development of effective antimicrobial agents. **Materials and Methods:** Using pan-genomic analysis of the core protein repertoire of K. pneumoniae, we applied a subtractive proteom In vitro evaluation, Klebsiella pneumoniae, Molecular docking, Molecular dynamics simulation, Subtractive proteomics, Virtual screening https://www.ijper.org/cardioprotective-role-of-flavokawain-a-against-isoproterenol-induced-acute-myoca 2026-04-13T05:54:04.322743+00:00 Cardioprotective Role of Flavokawain A against Isoproterenol-Induced Acute Myocardial Infarction in Rats via Modulation of NF-?B/HO-1/NQO-1 Pathways 2025-03-06 10.5530/ijper.20257348 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-747.pdf **Background:** Myocardial Infarction (MI) is a prevalent condition of heart disease. Despite remarkable growth in the treatment of heart diseases, MI remains the foremost cause of mortality worldwide and a significant pathological concern. **Objectives:** The primary aim of this work is to analyze the therapeutic activities of flavokawain A on Isoproterenol (ISO)-induced MI in rats. **Materials and Methods:** The rats were administered with ISO (85 mg/kg) in order to induce MI and pretreated Myocardial infarction, Flavokawain A, Inflammation, Ca2+ ATPase, Antioxidants. https://www.ijper.org/insights-of-nanoemulsion-as-a-drug-delivery-system-an-overview-of-current-trends 2026-04-13T05:54:04.322743+00:00 Insights of Nanoemulsion as a Drug Delivery System: An Overview of Current Trends and Applications 2025-03-06 10.5530/ijper.20250937 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-472.pdf The ability of nanoemulsion to improve the solubility, bioavailability and stability of weakly water-soluble drugs has emerged their roles as promising drug delivery systems. Nanoemulsion is advanced colloidal systems made up of nanometer-sized droplets (usually 20-200 nm) scattered in two immiscible liquids and stabilized by surfactant. It offers a flexible substrate for enclosing both hydrophobic and hydrophilic medications. Owing to the tiny droplet size, there is more surface area available Nanoemulsion, Formulations, Characteristic, Drug delivery, Application. https://www.ijper.org/case-study-effect-of-co-po-mapping-and-attainment-on-third-year-b-pharm-students 2026-04-13T05:54:04.322743+00:00 Case Study: Effect of CO-PO Mapping and Attainment on Third-Year B Pharm Students 2025-03-06 10.5530/ijper.20250859 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-535.pdf **Aim/Background:** This paper discusses a case study using CO-PO mapping and accomplishment for Tier II institutes' third-year B.Pharm students. It is required to be outcome-based education in accordance with the National Board of Accreditation's June 2015 scheme. There are observable disparities in students' employability when it comes to the acquisition of professional expertise and abilities and the growth of an attitude of professionalism. Tier II students have a significant chance to close CO-PO attainment, CO-PO mapping, Employability, Learning Objective, Learning Outcome, Outcome Based Accreditation, Program Outcomes. https://www.ijper.org/characterization-and-evaluation-of-antidiabetic-potentials-of-plectranthus-amboi 2026-04-13T05:54:04.322743+00:00 Characterization and Evaluation of Antidiabetic Potentials of Plectranthus amboinicous-Derived Nanoparticles 2025-03-06 10.5530/ijper.20250571 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-704.pdf **Background:** Plectranthus amboinicus (Lour.) Spreng, a member of the Lamiaceae family, is commonly utilized in both traditional medicine and culinary applications. This research focuses on optimizing the pharmacodynamic and pharmacokinetic characteristics of Plectranthus amboinicus by developing and assessing a nanoparticle formulation combined with gelatin. The objective was to evaluate the effectiveness of this nanoformulation in enhancing glucose metabolism and its potential as an antidiab Spherical, Glucose, Preadipocytes, Nanotechnology, Therapies, Solvent Evaporation. https://www.ijper.org/development-and-validation-of-discriminative-dissolution-test-for-tenofovir-diso 2026-04-13T05:54:04.322743+00:00 Development and Validation of Discriminative Dissolution Test for Tenofovir Disoproxil Fumarate Formulation 2025-03-06 10.5530/ijper.20257094 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-628.pdf **Objectives and Introduction:** This study uses HPLC and UV spectrophotometric methods to develop and validate a differential dissolution test method for quality control of tenofovir disoproxil fumarate in a tablet. Tenofovir disoproxil fumarate is a medicine used in combination therapy to treat HIV infection. It has antiviral, prodrug, and HIV-1 reverse transcriptase inhibitory properties. **Materials and Methods:** Phosphate buffer 6.8, water, and 0.01 N HCl were the components of the separa Discriminative dissolution, Dissolution test, HPLC, Tenofovir disoproxil fumarate. https://www.ijper.org/formulation-characterization-and-in-vivo-evaluation-of-5-fluorouracil-loaded-pol 2026-04-13T05:54:04.322743+00:00 Formulation, Characterization and in vivo Evaluation of 5-Fluorouracil-Loaded Polymeric Micelles for Non-Melanoma Skin Cancer 2025-03-06 10.5530/ijper.20251736 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-602.pdf **Background:** The goal of the study was to evaluate the prospective of fluorouracil-loaded polymeric micelles for topical delivery in non-melanoma skin cancer. **Materials and Methods:** Polymeric micelles were developed by thin film hydration technique and characterized for physico-chemical properties, in vitro drug release, ex vivo skin penetration as well as in vivo skin irritation and anticancer effect. **Results:** Preliminary studies were carried out in twelve Formulations (FM1-FM12) a Drug release, Fluorouracil, Polymeric micelles, Rats, Skin carcinoma. https://www.ijper.org/deciphering-molecular-insights-into-isocitrate-lyase-and-their-inhibitors-a-deta 2026-04-13T05:54:04.322743+00:00 Deciphering Molecular Insights into Isocitrate Lyase and their Inhibitors: A Detailed Display through Medicinal Chemistry Window 2025-03-06 10.5530/ijper.20255143 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-453.pdf **Aim:** Isocitrate lyase is the ancient glyoxylate cycle enzyme that catalyzes isocitrate cleavage into succinate and glyoxylate. The glyoxylate cycle is a key metabolic pathway as indicated by significant data on many host pathogens, which confirm the fundamental existence, in particular, causing life-threatening diseases, including tuberculosis. **Objectives:** Mycobacterium tuberculosis Isocitrate lyase and other organisms, which express ICL, have attracted the attention of molecular biolog Isocitrate Lyases, Mycobacterium tuberculosis, Glyoxylate cycle, Krebs cycle. https://www.ijper.org/chlorogenic-acid-functionalized-tin-oxide-sodium-alginate-hybrid-nanomaterials-i 2026-04-13T05:54:04.322743+00:00 Chlorogenic Acid Functionalized Tin Oxide-Sodium Alginate Hybrid Nanomaterials Induce Oxidative Stress-Mediated Apoptosis in Breast Cancer MDA-MB-231 Cells 2025-03-06 10.5530/ijper.20257391 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-757.pdf **Background:** Nanotechnology has emerged as a novel research area to address the several problems associated with existing cancer treatments. **Objectives:** The present work was focused on synthesizing and characterizing the tin oxide-sodium alginate-chlorogenic acid hybrid nanomaterials (SnO2-SA-CA HNMs) for enhanced anticancer effects against breast cancer MDA-MB-231 cells. **Materials and Methods:** The synthesized SnO2-SA-CA HNMs were characterized using several methods, including UV-vi Breast cancer, Nanomaterials, Apoptosis, Oxidative stress, Chlorogenic acid. https://www.ijper.org/pharmacotherapy-of-anorexia-nervosa-and-bulimia-nervosa-using-ssris-maois-and-tc 2026-04-13T05:54:04.322743+00:00 Pharmacotherapy of Anorexia Nervosa and Bulimia Nervosa Using SSRIs, MAOIs and TCAs 2025-03-06 10.5530/ijper.20250238 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-425.pdf **Abstract:** Anorexia nervosa and bulimia nervosa are mental disorders categorised under eating and feeding disorders (American Psychiatric Association). While psychotherapy is the main form of treatment, pharmacotherapy can also be used for these disorders. This paper discusses the use of Selective Serotonin Reuptake Inhibitors (SSRIs), Monoamine Oxidase Inhibitors (MAOIs) and Tricyclic Antidepressants (TCAs) in treating anorexia nervosa and bulimia nervosa. Studies found in the database provi Anorexia Nervosa, Bulimia Nervosa, Selective Serotonin Reuptake Inhibitors, Monoamine Oxidase Inhibitors, Tricyclic Antidepressants https://www.ijper.org/educational-implications-of-vark-learning-styles-academic-performance-and-pedago 2026-04-13T05:54:04.322743+00:00 Educational Implications of VARK Learning Styles: Academic Performance and Pedagogical Preferences among Korean Pharmacy Students 2025-03-06 10.5530/ijper.20250050 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-512.pdf **Background:** Understanding and adapting instruction to pharmacy students' learning styles can catalyze educational outcomes, fostering the transition from knowledge acquisition to actionable skills. We investigated the learning styles of pharmacy students using the VARK model and explored their preferences for instructional methods before developing a preceptorship curriculum. **Materials and Methods:** Our study employed a descriptive questionnaire-based approach involving pharmacy students Learning Style, Educational Measurement, Teaching, Academic Performance, Educational Status. https://www.ijper.org/recent-trends-in-top-down-technologies-for-the-preparation-of-nanosuspensions 2026-04-13T05:54:04.322743+00:00 Recent Trends in Top-Down Technologies for the Preparation of Nanosuspensions 2025-03-06 10.5530/ijper.20256434 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-493.pdf The increasing demands for drugs and advancements in drug discovery have led to the development of numerous potent molecules with unfavourable solubility and bioavailability characteristics. These challenges are driving significant developments in formulation technologies, such as nanosuspensions, which can potentially address these challenges and improve the success rate of new molecules. Nanosuspensions have unique properties due to their size, which can enhance solubility, adapt to surface mo Nanosuspension, Solubility and bioavailability enhancement, Preparation methods, Formulation considerations, Characterization techniques. https://www.ijper.org/anti-arthritic-effect-of-traditional-chinese-medicinal-compound-bavachalcone-on 2026-04-13T05:54:04.322743+00:00 Anti-Arthritic Effect of Traditional Chinese Medicinal Compound Bavachalcone on Freund’s Complete Adjuvant-Induced Rheumatoid Arthritis in Rats 2025-03-06 10.5530/ijper.20257346 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-727.pdf **Background:** Oxidative stress and inflammation are suggested to be the major etiological factors for the autoimmune disease rheumatoid arthritis. Rheumatoid arthritis affects millions of individuals all over the world even though mortality rate is comparatively lower than the other autoimmune diseases it severely affects the quality life of the patients. Lack of timely and proper medical intervention could cause deformity bones leading to chronic pain, long term disability and also premature Rheumatoid Arthritis, Oxidative stress, Inflammation, Anti-arthritis drug, Traditional Chinese medicine, Bavachaclone. https://www.ijper.org/materiovigilance-an-emerging-area-for-exploration-in-pharmaceutical-education-a 2026-04-13T05:54:04.322743+00:00 Materiovigilance: An Emerging Area for Exploration in Pharmaceutical Education-A Comparative Appraisal of Knowledge, Attitudes and Practices among Pharmacists and Healthcare Professionals 2025-03-06 10.5530/ijper.20250656 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-2-518.pdf **Background:** Materiovigilance is essential for monitoring the safety and performance of medical devices. This study aimed to assess the Knowledge, Attitudes and self-reported Practices (KAP) of healthcare professionals regarding the use and monitoring of implantable and other medical devices in and around Perinthalmanna, Kerala, India. **Materials and Methods:** This prospective observational study was conducted over a three-month period at KIMS Al-Shifa Super Specialty Hospital, Perinthalma Materiovigilance, Healthcare Professionals, Knowledge, Attitude, Practices, Medical Device Adverse Event. https://www.ijper.org/bio-simulation-studies-of-valganciclovir-hydrochloride-molecular-descriptor-base 2026-04-28T07:05:41.728577+00:00 Bio-Simulation Studies of Valganciclovir Hydrochloride: Molecular Descriptor-Based QSAR Modelling and Swiss ADME Analysis Using in silico Models 2025-02-04 10.5530/ijper.20251137 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-132.pdf Aim: To evaluate the pharmacokinetics and toxicity properties of Valganciclovir Hydrochloride, a potent antiviral agent, using in silico models. Background: Valganciclovir Hydrochloride is an FDA-approved antiviral agent and understanding its pharmacokinetic and toxicological properties is critical for optimizing its use. Objectives: To assess the pharmacokinetic properties, toxicity profile and bioactive characteristics of Valganciclovir Hydrochloride using computational in silico models. Mater In silico Modelling, Valganciclovir Hydrochloride, Pharmacokinetics, Toxicity Assessment, Molecular Descriptor, QSAR Modelling https://www.ijper.org/rp-hplc-single-advance-method-with-validation-studies-for-imipramine-hydrochlori 2026-04-28T08:53:15.05539+00:00 RP-HPLC Single Advance Method with Validation Studies for Imipramine Hydrochloride and its Intermediates 2025-02-04 10.5530/ijper.20256210 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-283.pdf Background: A quantifiable method has been developed to determine the key starting material, its intermediates and known impurities in the presence of Imipramine Hydrochloride in the final API of a synthetic laboratory sample. This newly developed Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) method is, facile, specific and reliably practical. Materials and Methods: The separation column employed was Inertsil ODS-3 C18 with a mobile phase comprised of (A) 0.1% OPA (pH adjusted t Imipramine Hydrochloride, API, RP-HPLC, UV detector, Chromatogram, Validation https://www.ijper.org/chitosan-based-linezolid-dry-powder-inhalers-a-novel-approach-for-targeted-pulmo 2026-04-28T07:07:14.258677+00:00 Chitosan-Based Linezolid Dry Powder Inhalers: A Novel Approach for Targeted Pulmonary Delivery in Tuberculosis Treatment 2025-02-04 10.5530/ijper.20250001 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-138.pdf Introduction: Tuberculosis (TB) remains one of the leading causes of infectious deaths worldwide, ranking second only to COVID-19. The rise of Multidrug-Resistant (MDR) and Extensively Drug-Resistant (XDR) TB strains highlights the critical need for novel and effective treatment approaches. Methodology: This research explores a targeted pulmonary drug delivery system using Dry Powder Inhalers (DPI) to administer the antibiotic Linezolid (Lzd) directly to the lungs. Biodegradable Microparticles ( Linezolid, Multi-Drug Resistant Tuberculosis (MDR-TB), Mycobacterium tuberculosis, Chitosan Microparticles, Pulmonary delivery https://www.ijper.org/bio-conjugated-metallic-complexes-in-drug-design 2026-04-28T06:36:03.418399+00:00 Bio-Conjugated Metallic Complexes in Drug Design 2025-02-04 10.5530/ijper.20255296 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-16.pdf Background: This comprehensive review highlights the importance of bio-conjugated metallic complexes in drug design, particularly in the field of metallo-pharmaceutical science. The review emphasizes the need for biological relevance and the coordination of biomolecules or modified bio-compounds with metallic systems to maximize drug action and minimize toxicity. Materials and Methods: The objective of this review is to discuss various diseases, which exemplify the potential of bio-conjugated me Bio-conjugation, Metallic complexes, Drug design, Metallo-pharmaceutical science, Antioxidants, Chelate https://www.ijper.org/formulation-and-evaluation-of-acyclovir-loaded-aspasomal-gel-for-effective-manag 2026-04-28T06:59:53.008263+00:00 Formulation and Evaluation of Acyclovir Loaded Aspasomal Gel for Effective Management of Herpes 2025-02-04 10.5530/ijper.20254263 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-121.pdf Objectives: The aim of the present study is to formulate and evaluate acyclovir loaded aspasomal topical gel by using Aloe vera gel base to enhance skin permeation and reduce the associated oral side effects of acyclovir. Materials and Methods: Acyclovir loaded aspasomes were formulated by using Ascorbyl Palmitate, Cholesterol and Chloroform: Methanol in 9:1 ratio by Thin Film Hydration Method. Phosphate Buffer Solution (PBS) pH 7.4 was used to hydrate the film obtained. The formulated aspasomes Herpes, Acyclovir, Aspasomes, Herpes Simplex Virus https://www.ijper.org/fabrication-and-comparative-assessment-of-solid-dispersion-and-nanosuspension-in 2026-04-28T06:46:43.5199+00:00 Fabrication and Comparative Assessment of Solid Dispersion and Nanosuspension in Solubility Enhancement of Antihypertensive Drug 2025-02-04 10.5530/ijper.20254202 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-63.pdf Background: Azilsartan, a poorly soluble angiotensin receptor blocker belonging to BCS class II, faces challenges related to low solubility and bioavailability. To address these issues, this study compares two formulation approachessolid dispersion and nanosuspension-aimed at enhancing the solubility and bioavailability of Azilsartan. Materials and Methods: Nine batches of Azilsartan-solid dispersion were prepared using spray drying with HPMC E5 LV, while nine batches of nanosuspension were form Azilsartan, Solid dispersion, Nanosuspension, Solubility, Hypertension https://www.ijper.org/investigating-the-impact-of-acute-and-28-days-oral-exposure-to-decaprenyl-phosph 2026-04-28T07:14:13.288849+00:00 Investigating the Impact of Acute and 28-days Oral Exposure to Decaprenyl phosphoryl-β-D-ribose 2’- epimerase (DprE1) Inhibitors on Vital Organ Function in Swiss Albino Mice 2025-02-04 10.5530/ijper.20256810 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-151.pdf Aim/Background: Tuberculosis (TB) is a severe airborne infectious disease caused by Mycobacterium tuberculosis, a contagious bacillus and the second leading cause of mortality. A pivotal obstacle in Tuberculosis (TB) therapy lays in the swift emergence of resilient TB mycobacterial variants during treatment regimens, thereby precipitating the dissemination of Multi-Drug Resistant (MDR-TB) and extensively drug-resistant M. tuberculosis (XDR-TB) strains. The objective of present study to evaluate Toxicity, Antitubercular Agents, DprE1 Inhibitors, NCEs https://www.ijper.org/characterisation-and-toxicity-evaluation-of-synthesized-phloridzin-chitosan-nano 2026-04-28T06:54:02.737914+00:00 Characterisation and Toxicity Evaluation of Synthesized Phloridzin Chitosan Nanoparticles in in vivo Model 2025-02-04 10.5530/ijper.20255549 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-102.pdf Background: Phloridzin, a plant compound is of interest in the field of research due to its antioxidant, anti-inflammatory, anticancer and antidiabetic activity. The current study's objectives were to create, characterize and evaluate the toxicity of synthesized phloridzin chitosan nanoparticles in Sprague Dawley rats. Materials and Methods: The chitosan nanoparticle was synthesized by ionic gelation method. The synthesized nanoparticles were characterized using different techniques like Dynamic Phloridzin, Chitosan nanoparticle, Toxicity, Liver, Kidney, Brain https://www.ijper.org/role-of-broccoli-fiber-for-amoxicillin-delivery-and-gut-biome-survival 2026-04-28T07:24:09.311443+00:00 Role of Broccoli Fiber for Amoxicillin Delivery and Gut Biome Survival 2025-02-04 10.5530/ijper.20255476 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-198.pdf Aim: Broccoli fiber has enormous safety net as well as high pre-biotic value. Amoxicillin is although an effective drug against infections is equally harmful to gut microbiota and therefore the above side-effect impedes the use of amoxicillin. The present study deals with evaluating the dual benefits of the partially depolymerized fiber to deliver amoxicillin when the same is used as base fiber in lieu of Micro Crystalline Cellulose (MCC), as well as in protecting the gut microbiota by serving a Amoxicillin delivery, Broccoli, Tablet excipients, Probiotic protection, Probiotics https://www.ijper.org/antimicrobial-utilization-in-a-rural-childrens-hospital-of-south-india 2026-04-13T05:54:05.158325+00:00 Antimicrobial Utilization in a Rural Children’s Hospital of South India 2025-02-04 10.5530/ijper.20255423 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-355.pdf **Background:** The “more-is-better” antimicrobial prescribing philosophy besides resistance is a significant contributor to suffering and death in children. Only a few nations have given comprehensive and comparable statistics on pediatric antimicrobial usage. However, such pediatric research is scarce in India, which necessitates antimicrobial pharmaco-surveillance. **Materials and Methods:** The retrospective antimicrobial drug use study was conducted in a rural children’s hospital of south Antimicrobials, ATC/DDD Index, Drug Utilization, Observational Studies https://www.ijper.org/biomarkers-unveiling-neurodegeneration-keys-to-progression-and-therapeutic-insig 2026-04-28T06:34:41.308795+00:00 Biomarkers Unveiling Neurodegeneration: Keys to Progression and Therapeutic Insights 2025-02-04 10.5530/ijper.20250179 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-1.pdf Neurodegenerative diseases constitute a pressing global health challenge, characterized by the gradual loss of neuronal function and structure, leading to cognitive impairment and motor deficits. Biomarkers play a crucial role in understanding the complex pathophysiological pathways of neurodegenerative disorders. By analyzing a variety of recent studies and advancements in the field, we aim to unravel the potential of biomarkers in not only facilitating early diagnosis but also shedding light Neurodegenerative Diseases, Biomarkers, Dementia, Cerebrospinal Fluid, Blood-Brain Barrier, Neuroimaging Techniques https://www.ijper.org/a-psychological-exploration-towards-indian-education-fraternity-during-the-covid 2026-04-13T05:54:05.158325+00:00 A Psychological Exploration Towards Indian Education Fraternity during the COVID-19 Pandemic 2025-02-04 10.5530/ijper.20255436 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-347.pdf **Aim/Background:** The purpose of the current study is to understand the COVID-19 pandemic as the greatest psychological challenge that humankind has ever faced. COVID-19 started in China in December 2019 and has conquered the whole world today. Everyone is responding to this pandemic in their own unique way and psychologically facing a global threat in the process. This paper seeks to examine how COVID-19 has psychologically affected the education sector. The purpose of the study is to analyze COVID-19, Education, Pandemic, Psychology, ANOVA https://www.ijper.org/comparative-study-of-aqueous-and-alcoholic-extracts-of-roots-of-bauhinia-variega 2026-04-13T05:54:05.158325+00:00 Comparative Study of Aqueous and Alcoholic Extracts of Roots of Bauhinia variegata Linn. on Cafeteria Diet Induced Obesity 2025-02-04 10.5530/ijper.20254509 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-367.pdf **Background:** Obesity is typically characterized by excess deposition of adipose tissue. Along with dietary management, increase in physical activity, lifestyle modification, surgical intervention, drug treatment is also available which aid in weight loss. However, most of these drugs exhibit side effects like insomnia, irritability, epigastric discomfort, constipation, some are even habit-forming drugs. Hence, the present study was designed to screen, evaluate and discover newer safer anti-ob Bauhinia variegata Linn, Cafeteria diet, Anti-obesity activity, Serum biochemical parameters, Histopathological studies https://www.ijper.org/preclinical-evaluation-of-thrombocytopenic-activity-of-hydro-alcoholic-extract-o 2026-04-28T07:22:37.290415+00:00 Preclinical Evaluation of Thrombocytopenic Activity of Hydro-Alcoholic Extract of Psidium guajava L. Fruits on Wistar Rats with in silico Modelling on Dengue Virus Protease Inhibitors 2025-02-04 10.5530/ijper.20250199 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-190.pdf Background: The prime objective of the investigation is to measure the capability of expanding the enumeration of platelet in rodent model utilizing hydro-alcoholic extract of Psidium guajava L. fruit in addition with in silico modelling on Dengue Virus Protease Inhibitors. Materials and Methods: Using a double maceration procedure with 30% water and 70% ethanol, the harvested fruit was extracted. Heparin-induced thrombocytopenic rats were used to assess the extract's thrombocytopenic action. Pr Heparin, Psidium guajava L., Prednisolone, Haemocytometer, Platelet count, QSAR studies https://www.ijper.org/article/59/1s/s256-s263 2026-04-28T08:02:09.940807+00:00 A Comprehensive LC-MS/MS Method for Detecting Genotoxic Nitrosamine Impurities in Favipiravir API 2025-02-04 10.5530/ijper.20250167 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-256.pdf Background: Favipiravir, a purine nucleic acid analogue (T-705), was used to treat SARS-CoV-2 patients. Existing methods often target specific nitrosamines in various matrices but not necessarily Favipiravir. These findings highlight the lack of a comprehensive method for detecting all seven potential nitrosamine impurities in Favipiravir API. Materials and Methods: The current approach discusses the trace-level quantification of nitrosamine impurities (NDEA, NDIPA, NEIPA, NMBA, NMPA, NDMA and N NEIPA, NDIPA, NMPA, Favipiravir API, NDBA, Genotoxic impurities, ESI(+ve). https://www.ijper.org/unlocking-anti-inflammatory-potential-virtual-discovery-and-admet-evaluation-of 2026-04-28T09:04:28.918753+00:00 Unlocking Anti-Inflammatory Potential: Virtual Discovery and ADMET Evaluation of Novel Pyrazole-Based COX-II Inhibitors 2025-02-04 10.5530/ijper.20256457 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-312.pdf Background: Inflammation, a complex biological process mediated by arachidonic acid metabolites, plays a crucial role in various diseases like arthritis, psoriasis and neurodegenerative disorders. The Cyclooxygenase (COX) pathway, particularly COX-2, is a well-established anti-inflammatory target. Materials and Methods: This study aimed to discover and evaluate novel pyrazole derivatives as potential COX-2 inhibitors via virtual screening. The 3D crystal structure of Cyclooxygenase-II (PDB: 1CX2 Inflammation, COX 2, Molecular docking, ADMET, Pyrazole https://www.ijper.org/review-of-existing-antibiotic-stewardship-and-impact-on-antimicrobial-resistance 2026-04-28T06:42:37.084786+00:00 Review of Existing Antibiotic Stewardship and Impact on Antimicrobial Resistance during COVID-19 in the Health Sector of the Emirate of Abu Dhabi, United Arab Emirates 2025-02-04 10.5530/ijper.20255637 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-46.pdf This study examined the present situation of Antimicrobial Resistance (AMR) and prevailing Antimicrobial Stewardship Programs (ASP), and its impact during COVID-19 globally and specifically in Abu Dhabi, UAE aiming to identify and define the problem(s) resulting in increasing trends of antibiotic resistance during COVID, potential impact factors, anticipated outcomes and provide a conclusion to aid our approach towards sustainable antimicrobial stewardship program and combat against antimicrob In-patient, Antibiotic Stewardship, Antimicrobial Resistance, Hospitalized Patients, Readmissions https://www.ijper.org/insight-into-the-synthesis-approaches-of-oxadiazole-and-its-derivatives-focuses 2026-04-28T06:40:53.388253+00:00 Insight into the Synthesis Approaches of Oxadiazole and its Derivatives, Focuses on their Pharmacological Activities 2025-02-04 10.5530/ijper.20250270 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-25.pdf Oxadiazoles and their derivatives represent a significant class of organic compounds, wielding profound implications in both the realms of medicinal science and heterocyclic rings housing oxygen and nitrogen atoms, has garnered attention owing to their multifaceted. Pharmacological potential. The diverse array of biological activities exhibited by oxadiazole derivatives spans antimicrobial, anti-inflammatory, anti-cancer and anti-viral effects. Beyond medicinal applications, these compounds show Oxadiazole, Oxadiazole Derivative, Synthesis, Biological Activity https://www.ijper.org/hansen-solubility-parameter-approach-in-the-screening-of-lipid-excipients-for-th 2026-04-28T06:48:07.024483+00:00 Hansen Solubility Parameter Approach in the Screening of Lipid Excipients for the Development of Lipid Nano Carriers 2025-02-04 10.5530/ijper.20254852 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-71.pdf Background: The complex physicochemical properties of the lipids have considerable impact on the solubility and stability of the Lipid Based Nanocarriers (LBN). The major challenge in the successful development of LBN lies on the selection of suitable lipid and its ability to achieve high drug payloads. The wet lab screening of lipids is time consuming and economically not viable. Therefore, the present research aims to apply Hansen solubility parameters to predict the solubility/miscibility of Solubility parameter, Computational Pharmaceutics, Curcumin, 5-FU, Solubility https://www.ijper.org/evaluation-of-antiparkinsonism-activity-of-manilkara-zapota-l-p-royen-leaf-extra 2026-04-28T07:18:13.019489+00:00 Evaluation of Antiparkinsonism Activity of Manilkara zapota (L.) P. Royen Leaf Extract in Haloperidol-Induced Parkinsonism in Swiss Albino Mice 2025-02-04 10.5530/ijper.20250031 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-179.pdf Background: Manilkara zapota, a plant with a rich history in traditional medicine, holds potential as a therapeutic agent. However, its neuroprotective properties remain largely unexplored, highlighting the need for further scientific research to understand its potential in this regard. Objectives: This study aimed to explore the neuroprotective effects of Manilkara zapota ethanolic extract against haloperidol-induced Parkinsonism in Swiss albino mice. Materials and Methods: The M. zapota leaf p Manilkara zapota (L.) P. Royen, Haloperidol, Ethanolic extract, Histological studies https://www.ijper.org/knowledge-attitude-and-practice-kap-of-the-healthcare-professionals-and-communit 2026-04-28T08:33:42.091087+00:00 Knowledge, Attitude and Practice (KAP) of the Healthcare Professionals and Community towards Patient Counselling in Tertiary Care Hospital 2025-02-04 10.5530/ijper.20254916 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-264.pdf Background: Patient counselling is recognized as an integral component of healthcare services, providing essential guidance to patients. However, it has been observed that in India, practical attendance of designated patient education sessions is not emphasised. Therefore, the principal aim of this research endeavour was to evaluate the Knowledge, Attitude, and Practice of Healthcare Professionals (HCPs) and the Community towards patient education. Materials and Methods: This research aimed to a Attitude and Practice, Clinical Pharmacist, Knowledge, Patient Counselling https://www.ijper.org/ziziphus-hamur-engl-a-rare-medicinal-plant-modulates-cytokine-and-hematological 2026-04-28T07:46:57.588862+00:00 Ziziphus hamur Engl., a Rare Medicinal Plant Modulates Cytokine and Hematological Levels during Sub-Acute Toxicity Studies in Wistar Rats 2025-02-04 10.5530/ijper.20257420 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-229.pdf Introduction: Ziziphus hamur Engl. (Vernacular name: Xamur gob) is a thorny shrub native to Ethiopia, Kenya and Somalia. The plant is extensively used in the traditional system of the Somali region in the treatment of jaundice and mental illness. Lack of prior experimental studies and wide usage in traditional medicine demands the toxicological evaluation of Ziziphus hamur Engl. The aim of this study was to evaluate the safety of Ziziphus hamur root bark by sub-acute toxicity study in male albin Traditional medicine, Biochemical, Histological, Hematology, Cytokines https://www.ijper.org/stability-indicating-rp-hplc-method-development-and-validation-for-the-simultane 2026-04-28T08:44:22.866627+00:00 Stability Indicating RP-HPLC Method Development and Validation for the Simultaneous Quantification of Remogliflozin Etabonate and Metformin HCl 2025-02-04 10.5530/ijper.20253781 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-274.pdf Aim: This Study aimed to develop a stable, efficient, and reproducible RP-HPLC method that indicates stability, for the simultaneous determination of Remogliflozin Etabonate and Metformin HCl. Materials and Methods: The Separation Process By using Methanol: 0.05 M KH2 PO4 (75:25%v/v) as the mobile phase and a linear gradient protocol with a detection wavelength of 240 nm, the chromatographic separation was accomplished on (Anachrom) Cosmosil C18 (250×4.6 mm, 5 µm) Column. 35ºC was the column tem Remogliflozin, Etabonate, Metformin HCl, RP-HPLC Method, Validation, Stability, Degradation https://www.ijper.org/lc-msms-method-for-simultaneous-estimation-of-lopinavir-and-ritonavir-in-bulk-an 2026-04-28T08:57:07.825289+00:00 LC-MS/MS Method for Simultaneous Estimation of Lopinavir and Ritonavir in Bulk and Dosage Form 2025-02-04 10.5530/ijper.20256853 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-292.pdf Aim: This study introduces a novel simultaneous analytical quantification of Lopinavir (LPV) and Ritonavir (RTV) in drug products by using LC-MS/MS. Materials and Methods: The present study were carried out on Acquity™ LC system from Waters paired with a triple quadrupole mass spectrometer and employing positive ion mode for optimal mass spectra. The developed method exhibited molecular and product ions for both analytes for improved resolution and signal intensity, choosing an 80:20 v/v mobile UPLC-MS/MS, Method development, Simultaneous estimation, Validation https://www.ijper.org/hydrotropy-as-a-tool-for-enhancing-mefenamic-acid-solubility-a-comprehensive-stu 2026-04-28T06:44:21.352001+00:00 Hydrotropy as a Tool for Enhancing Mefenamic Acid Solubility: A Comprehensive Study 2025-02-04 10.5530/ijper.20250092 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-52.pdf Background: Nonsteroidal anti-inflammatory drugs, or NSAIDs, including mefenamic acid, are commonly used for the relief of moderate to serious pain. However, their poor water solubility affects their bioavailability and potential therapeutic benefit. Improving the solubility of these poorly soluble medications is essential for optimizing their therapeutic efficacy. The use of hydrotropic agents, or hydrotropy, has become a popular method for improving solubility. Materials and Methods: Argon Rem Mefenamic acid, Hydrotropy, Sodium salicylate, Sodium acetate, Resorcinol, Solubility https://www.ijper.org/qbd-based-development-characterization-and-pharmacokinetic-evaluation-of-enzalut 2026-04-28T06:52:44.509692+00:00 QbD Based Development, Characterization and Pharmacokinetic Evaluation of Enzalutamide-Loaded Cyclodextrin Nano Sponges for Enhanced Drug Delivery 2025-02-04 10.5530/ijper.20255427 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-89.pdf Aim/Background: The aim of this study was to enhance the bioavailability of Enzalutamide by developing cross-linked cyclodextrin nanosponges loaded with the drug (EZL-CDNS). The objective of the work is to thoroughly investigate the impact of different molar ratios of DPC and cyclodextrin on the fundamental properties of EZL-CDNS, such as particle size, entrapment efficiency, and zeta potential. Materials and Methods: The Box-Behnken design methodology was employed to systematically investigate Enzalutamide, Cyclodextrin, Nanosponges, Box-Behnken Design, Pharmacokinetics https://www.ijper.org/the-clinical-implications-of-thyroid-dysfunction-and-its-association-with-dyslip 2026-04-28T07:16:34.242231+00:00 The Clinical Implications of Thyroid Dysfunction and its Association with Dyslipidemia and the Geographical Effect: A Comparative Study from Different Altitudes in Saudi Arabia 2025-02-04 10.5530/ijper.20255187 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-169.pdf Background: Thyroid disorder is one of the most prevalent critical issues for public health in clinical practice. Lipid profiles and cardiovascular attenuation are significantly affected by thyroid dysfunction. Thyroid dysfunction related to altitudes (height from sea level) has attracted endocrinologists worldwide. Objectives: The current study aimed to investigate the prevalence of thyroid dysfunction and its association with lipid profile among the Saudi population residing at different altit Thyroid dysfunction, Lipid profile, Lipid ratio, High altitudes, Sea level, Hypothyroidism, Hyperthyroidism https://www.ijper.org/azadirachta-indica-fruit-mucilage-aided-mucoadhesive-microspheres-of-acyclovir-f 2026-04-28T07:48:42.484193+00:00 Azadirachta indica Fruit Mucilage Aided Mucoadhesive Microspheres of Acyclovir for Drug Entrapment and Mucoadhesive Time Assets with Design-Expert Software 2025-02-04 10.5530/ijper.20256428 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-243.pdf Introduction: Mucoadhesive microspheres for drug delivery are retained in the stomach for an extended period for localized drug release and effect. Objectives: This research aims to explore the mucoadhesive properties of Azadirachta indica fruit mucilage when incorporated into mucoadhesive microspheres, utilizing Acyclovir as a model drug. Materials and Methods: Employing a Box Behnken design, 13 formulations of microspheres were developed, varying Azadirachta indica Mucilage (AIFM) levels, carb Acyclovir, Azadirachta indica, Design, Delivery, Microspheres, Mucoadhesion https://www.ijper.org/use-of-antidiabetic-drugs-and-glycemic-control-with-life-style-management-in-typ 2026-04-13T05:54:05.158325+00:00 Use of Antidiabetic Drugs and Glycemic Control with Life Style Management in Type II DM-A Cross-Sectional Study General Practice in Odisha 2025-02-04 10.5530/ijper.20255065 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-390.pdf **Aim/Background:** Our objective is to describe the patterns of prescribing drug combinations and lifestyle modification in which therapy focuses on SGLT2 and DPP4 inhibitors and dose variation according to the blood glucose level and the effective therapy in patients with T2DM. **Materials and Methods:** Using both prescription and questionnaire analysis, a cross-sectional study conducted in Odisha, including 100 diabetic subjects, is considered to evaluate effective combination therapy by co Diabetes, Drug, Drug Utilisation Pattern, DPP4i, SGLT2i https://www.ijper.org/comparative-study-of-quercetin-content-in-marketed-seeds-of-linum-usitatissimum 2026-04-28T07:44:37.269956+00:00 Comparative Study of Quercetin Content in Marketed Seeds of Linum usitatissimum L. (Flax), Salvia hispanica L. (Chia), and Helianthus annuus L. (Sunflower) and their Microgreens Using HPTLC from West Bengal 2025-02-04 10.5530/ijper.20255309 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-221.pdf Background: Microgreens, the early developmental stage of edible plants, have gained prominence for their dense nutrient composition. Yet the variations in quercetin content among different microgreen species remain insufficiently explored. Aim: The aim of this research was to use HPTLC to compare the quercetin content of commercial flax, chia, and sunflower seeds as well as the comparable microgreens. Materials and Methods: Toluene, ethyl acetate, and formic acid were used as the mobile phase a Microgreens, Quercetin, Comparative nutritional value, Linumusitatissimum L. (Flax), Salviahispanica L. (Chia), Helianthus annuus L. (Sunflower) https://www.ijper.org/statistically-optimized-nano-emulsion-enhances-bone-regeneration-efficiency-of-i 2026-04-28T07:15:30.14247+00:00 Statistically Optimized Nano Emulsion Enhances Bone Regeneration Efficiency of Ipriflavone in Osteoporosis-Induced Zebrafish Model 2025-02-04 10.5530/ijper.20256334 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-159.pdf Background: The objective of this research was to develop a nano emulsion of ipriflavone (IP nano emulsion), a soy isoflavone to enhance its solubility, bioavailability and bone regeneration potential. Materials and Methods: The oil phase and surfactants for the IP nano emulsion were selected by plotting ternary phase diagrams. Optimisation of surfactant and oil concentrations was achieved using the Box-Behnken Design in Design Expert software. A monodisperse nano emulsion was produced using son Ipriflavone, Nano emulsion, Osteoporosis, Zebrafish model, Bone regeneration https://www.ijper.org/design-and-synthesis-of-n-phenyl-2-phenyl-amino-acetamide-derivatives-as-fviia-i 2026-04-28T10:07:42.389818+00:00 Design and Synthesis of N-Phenyl-2-(Phenyl-Amino) Acetamide Derivatives as FVIIA Inhibitors for Effective Anticoagulant Activity 2025-02-04 10.5530/ijper.20255768 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-333.pdf **Aim:** Factor Vila is a glycosylated disulfide-linked heterodimer that belongs to the serine protease family involved in the coagulation process. Inhibition of factor Vila is one of the crucial targets for novel anticoagulant agents. Coagulation factor Vila inhibition has recently attracted attention as an intriguing antithrombotic therapeutic strategy. With the aid of X-ray crystallography and structure-based design, we were able to discover a novel series of N-phenyl-2-(phenyl-amino) acetami N-phenyl-2-(phenyl amino) acetamide, Factor Viia, Pyrex, X-ray crystallography, Prothrombin time https://www.ijper.org/formulation-and-evaluation-of-temperature-sensitive-in-situ-ocular-gel-drug-deli 2026-04-28T06:51:23.756742+00:00 Formulation and Evaluation of Temperature Sensitive in situ Ocular Gel Drug Delivery System of Acetazolamide for the Treatment of Glaucoma 2025-02-04 10.5530/ijper.20255365 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-81.pdf Background: Conventional eye formulations are generally flushed away from the lacrimal area due to the rapid elimination of drugs from this region, with only a small amount being absorbed. The short-term precorneal contact time, coupled with corneal impermeability, leads to decreased bioavailability, necessitating repeated instillation of drops. Therefore, there is an urgent need for a system that can address these issues, maintain sustained drug action and enhance effectiveness. Numerous attemp Acetazolamide, In situ ocular gel, Glaucoma, Ophthalmic gels https://www.ijper.org/the-effect-of-pharmaceutical-care-practices-on-clinical-problem-solving-decision 2026-04-13T05:54:05.158325+00:00 The Effect of Pharmaceutical Care Practices on Clinical Problem-Solving Decision-Making Competencies and Students’ Preparedness: A Cross Sectional Study 2025-02-04 10.5530/ijper.20255958 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-341.pdf **Background:** As clinical responsibilities continue to grow, it becomes essential for clinical pharmacists to acquire advanced competences, such as patient monitoring, patient-specific drug therapy design and evaluation, and collaboration with healthcare professionals. Pharmacy schools aspire to equip young pharmacists with competencies relevant to their current needs through the clinical practice courses they offer. Therefore, investigating the impact of clinical practice from the students’ p Clinical pharmacist competency, Experiential learning, Pharmacy education, Clinical pharmacy, Pharmaceutical care https://www.ijper.org/synthesis-and-evaluation-of-2-5-substituted-pyrazolone-for-neuroprotective-poten 2026-04-28T10:05:11.81185+00:00 Synthesis and Evaluation of 2, 5-substituted Pyrazolone for Neuroprotective Potential in SH-SY5Y Human Neuroblastoma Cells 2025-02-04 10.5530/ijper.20256349 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-323.pdf Aim: To carry out Synthesis and Evaluation of novel 2, 5-substituted Pyrazolone for Neuroprotective Potential in SH-SY5Y Human Neuroblastoma Cells. Materials and Methods: Alzheimer's Disease (AD) has become a serious public health concern as a result of people living longer than ever before. It is critically necessary to discover a way to halt and postpone the illness. The present study aims to determine if new synthetic analogue pyrazole derivatives may protect against toxicity caused by Aβ25-3 Cell viability, MTT assay, Neurodegenerative diseases, Neuroprotective agent, Pyrazole derivatives, SH-SY5Y cells https://www.ijper.org/effect-of-high-dose-folic-acid-supplementation-on-the-prevention-of-pre-eclampsi 2026-04-13T05:54:05.158325+00:00 Effect of High Dose Folic Acid Supplementation on the Prevention of Pre-Eclampsia in Pregnancy with Hypertension 2025-02-04 10.5530/ijper.20255955 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-361.pdf **Background:** “Pre-eclampsia” is one of the most dangerous pregnancy complications, increasing the risk of both the mother and the baby dying prematurely. Because there have been conflicting findings on whether folic acid can reduce the incidence of pre-eclampsia, we conducted a randomized clinical trial of high-dose folic acid administration to pregnant women at a high risk of pre-eclampsia. **Materials and Methods:** The study was a randomized clinical trial involving 1500 pregnant women. T Pre-eclampsia, Folic acid, Pregnant women, Primary outcome, Secondary outcome, Hypertension https://www.ijper.org/method-development-for-the-simultaneous-estimation-of-prazosin-and-polythiazide 2026-04-28T08:59:35.632704+00:00 Method Development for the Simultaneous Estimation of Prazosin and Polythiazide by UPLC Using QbD Approach 2025-02-04 10.5530/ijper.20250020 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-300.pdf Introduction: Prazosin is a quinazoline derivative and a selective antagonist of the α1 adrenergic receptor. The atomic structure is C19H21N5 O4 and its molecular weight is 383.41 Prazosin is a helpful medication for managing and treating various illnesses. Through the thiazide-sensitive Na-Cl co-transporter, at the early distal tubule the diuretic polythiazide prevents active chloride re-absorption, increasing the excretion of water, salt and chloride. Its molecular formula is C11H13ClF3 N3 O4 Polythiazide, Prazosin, International Conference Harmonization, UPLC, Quality by Design https://www.ijper.org/synthesis-molecular-docking-study-and-antimicrobial-evaluation-of-some-124-triaz 2026-04-13T05:54:05.158325+00:00 Synthesis, Molecular Docking Study and Antimicrobial Evaluation of Some 1,2,4-Triazole Compounds 2025-02-04 10.5530/ijper.20255394 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-375.pdf Aim: The objective of this study is synthesis of 1,2,4-triazole derivatives, evaluation there in vitro antimicrobial activity and showing the molecular docking. Materials and Methods: Two series of 5-alkylthio-3-aryl-4-phenyl-1,2,4-triazoles were successfully synthesized. The 1,2,4-triazole thiol was produced via cyclization reaction using the hydrazide compounds (2-hydroxybenzohydrazide and 5-bromofuran-2-carbohydrazide), which were then employed as nucleophilic species to attract various kinds Triazole, Antibacterial, Antifungal, Molecular docking, MIC, Modification of drug https://www.ijper.org/development-and-characterization-of-atenolol-based-microsponge-gel-for-ophthalmi 2026-04-28T06:56:47.571273+00:00 Development and Characterization of Atenolol Based Microsponge Gel for Ophthalmic Delivery 2025-02-04 10.5530/ijper.20255777 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-114.pdf Background: Ocular drug delivery is hindered by a number of reasons, including nasolacrimal drainage, tear turnover and eye blinking. One of the important factors is rapid removal of drug from the eye. The fast elimination rate of drug leads to the loss of drug from the conventional dosage form like eye drop. So, to avoid this problem a novel formulation was designed in which drug will entrap in micro sponges and the micro sponges will be laden into gel. Aim: The basic purpose of the study is to Microsponges, Gel, Atenolol, Glaucoma, Eudragit RS-100, Eudragit RL-100 https://www.ijper.org/in-vitro-evaluation-of-curcumin-and-quercetin-in-combination-on-oxidative-stress 2026-04-28T07:37:00.4398+00:00 In vitro Evaluation of Curcumin and Quercetin in Combination on Oxidative Stress 2025-02-04 10.5530/ijper.20254445 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-59-1s-214.pdf Background: Flavonoids are the natural product belongs to an important class of plant secondary metabolites. They are polyphenolic compounds and known for decades as a potent natural antioxidant. Curcumin (flavonoid polyphenol) and quercetin (flavonol) both are popular natural antioxidants and contributes a major role as an individual in the treatment of oxidative stress. This research study is more focused in their combination effect against oxidative stress. Materials and Methods: In this pres Authentication, Hydro-alcoholic maceration, Curcumin, Quercetin, Flavonoids, Oxidative stress https://www.ijper.org/effect-of-uzarin-isolated-from-calotropis-procera-on-blood-electrolytes-and-card 2026-04-28T07:27:51.368289+00:00 Effect of Uzarin Isolated from Calotropis procera on Blood Electrolytes and Cardiac Related Enzymes 2024-12-20 10.5530/ijper.58.1.22 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-204.pdf Background: Cardiac glycosides are known to be one of the most important drugs that extracted from medicinal plants. Cardiac glycosides have been used as a medicine for a long time with congestive heart failure. Objectives: In this study, we aim to investigate the biochemical changes happened in male rats by Uzarin, the cardiac glycoside isolated from Calotropis procera, to monitor the biochemical changes caused by cardiac glycosides in the long-term therapy or the overdose intake as well. Mater Uzarin, Cardiac glycosides, Calotropis procera, Serum electrolytes, Cardiac related, enzymes https://www.ijper.org/histopathological-changes-in-animal-models-by-catheters-coated-with-saudi-medici 2026-04-28T07:27:31.125624+00:00 Histopathological Changes in Animal Models by Catheters Coated with Saudi Medicinal Herb Evolvulus alsinoides L. Extract in Urinary Tract Infections by Klebsiella pneumoniae 2024-12-20 10.5530/ijper.58.1.24 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-220.pdf Background: Catheter-Associated Urinary Tract Infections (CA-UTIs) pose a significant danger especially when they are caused by multi-drug resistant strains of Klebsiella pneumoniae. As elsewhere in the world, Saudi Arabia also shows a higher prevalence of Klebsiella pneumoniae which complicates the treatment and management of the CA-UTIs. To tackle this, it is urgent to develop novel antibacterial compounds from natural sources and, phytochemicals have always been potential candidates. Evolvulu Biofilms, CA-UTIs, Guinea pigs, Inflammatory markers, Klebsiella pneumoniae, MDR, strains, Urinary catheters, Evolvulus alsinoides https://www.ijper.org/molecular-mechanism-of-apoptotic-cell-death-in-cyanidin-3-glucoside-induced-cyto 2026-04-28T07:27:17.037595+00:00 Molecular Mechanism of Apoptotic Cell Death in Cyanidin-3-glucoside-induced Cytotoxic Potential on Human Liver Carcinoma (HepG2) Cell Line 2024-12-20 10.5530/ijper.58.1.27 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-254.pdf Background: Liver cancer is one of the most prevalent cancers around the world and the leading cause of cancer-related deaths. Because liver cancer prevalence has increased significantly, there are no established therapies, and there are serious adverse reactions associated with the use of medications already available, new and more potent anticancer agents must be investigated. Aim: Using in vitro methods, we have assessed Cyanidin-3-glucoside (C3gc)'s anticancer activities and the underlying m Liver cancer, Cyanidin-3-glucoside, HepG2 cells, Reactive oxygen species, Apoptosis https://www.ijper.org/uv-spectrophotometric-method-development-and-validation-for-piperine-estimation 2026-04-28T07:26:49.319518+00:00 UV-spectrophotometric Method Development and Validation for Piperine Estimation in Black Pepper, Ayurvedic Formulation and Novel Nano Formulation: A Perfect Quality Assessment Tool 2024-12-20 10.5530/ijper.58.1.33 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-305.pdf Aim: The current study aims to establish and validate a UV-spectrophotometric approach for estimating piperine in black pepper, commercial Ayurvedic preparation, and novel piperine-loaded nanoformulation. Materials and Methods: The UV-spectrophotometric technique was developed using methanol as a solvent. Piperine showed the absorbance at 342 nm. In accordance with ICH Q2 (R1) guidelines, the developed method was extensively validated in terms of selectivity, linear range, precision, accuracy, r Piperine, Ayurvedic Preparation, UV-spectroscopic, Black pepper, Nanoformulation, ICH https://www.ijper.org/anti-cancer-potential-of-sinensetin-a-bioactive-compound-against-human-cervical 2026-04-28T07:28:17.438069+00:00 Anti-Cancer Potential of Sinensetin, a Bioactive Compound against Human Cervical Carcinoma Cells via its Molecular Mechanism of Apoptosis 2024-12-20 10.5530/ijper.58.1.16 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-154.pdf Background: Cancer is ranked among the world's leading causes of death in 2020 with an estimated 10 million recorded fatalities attributable to the disease. After breast, colorectal, and lung cancer, cervical cancer is the fourth most frequent disease in women worldwide. Each year, there are 6,00,000 new cases and 3,40,000 fatalities due to cervical cancer. HPV (Human Papilloma Virus), the main cause of cervical cancer, spreads to the cervix's epithelial cells during intercourse. Aim: The use of Cervical cancer, HeLa cells, Sinensetin, Apoptosis, Reactive oxygen species https://www.ijper.org/design-and-development-of-anti-fungal-topical-gel-loaded-with-solid-lipid-nanopa 2026-04-28T07:28:46.15261+00:00 Design and Development of Anti-fungal Topical Gel Loaded with Solid Lipid Nanoparticles for Wound Healing 2024-12-20 10.5530/ijper.58.1.13 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-131.pdf Background: The topical administration of antifungal drugs by Solid Lipid Nanoparticles (SLNs) has enormous potential. This study aimed to develop a topical 5-flucytosine-loaded SLNs gel to improve the efficacy of the well-known antifungal drug in the treatment of wound healing. Materials and Methods: In order to create 5-flucytosine SLNs, a five-level, two-factor Central-composite design was used. Stearic acid and Poloxamer 407 concentrations of surfactants were chosen as independent factors, a 5-Flucytosine, Solid lipid nanoparticle, Central-composite design, Topical delivery, Optimization https://www.ijper.org/investigation-of-the-pro-active-role-of-alpha-amyrin-nanoemulsions-in-quashing-n 2026-04-28T07:27:21.291506+00:00 Investigation of the Pro-active Role of Alpha Amyrin Nanoemulsions in Quashing Neurodegeneration, Excitotoxicity, and Neuronal Inflammation-A Combined in vivo and in silico Approach 2024-12-20 10.5530/ijper.58.1.26 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-240.pdf Background: Aluminium is a pervading metal that poses a serious threat causing severe brain damage and neuro-degeneration. Alpha amyrin a pentacyclic triterpene despite its potency has not been properly utilized to treat neurodegenerative disorders because of its erratic GI absorption and poor BBB permeability. Purpose: To determine the role of alpha amyrin nano-emulsion in neuroinflammation induced by aluminium through an in vivo and in silico approach. Materials and Methods: An in silico appro Aluminium, Alpha amyrin, Neuro-toxicity, Inflammatory markers, Nano-emulsion, Docking, Neuro-protection https://www.ijper.org/enlightening-pharmacological-mechanisms-of-cannabidiol-in-epilepsy-a-comprehensi 2026-04-28T07:17:00.134098+00:00 Enlightening Pharmacological Mechanisms of Cannabidiol in Epilepsy: A Comprehensive Review on their Neuroprotective Potential 2024-12-20 10.5530/ijper.58.1.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-015.pdf Cannabinoids interact with Cannabinoid Receptors (CBRs) and some related non-cannabinoid transcription factors within neurological and non-neuronal-specific receptors. The current review has covered pharmacological molecular mechanisms during an epileptic attack and provided a beneficial therapeutic approach for the treatment of neurological disorders. CBRs and new targets may be involved in Cannabidiol (CBD) effects. Although it has a low affinity for both CB1 and CB2 receptors, CBD can effecti Cannabinoids, Epilepsy, Experimental Models, Preclinical Study, Pharmacological, Mechanism, Neuroprotective Potential https://www.ijper.org/nigella-sativa-averts-5-fluorouracil-induced-kidney-injury-via-targeting-redox-i 2026-04-28T07:27:25.88598+00:00 Nigella sativa Averts 5-Fluorouracil Induced Kidney Injury via Targeting Redox Imbalance and MAPK Pathway 2024-12-20 10.5530/ijper.58.1.25 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-231.pdf Introduction: Chemotherapy-induced organ toxicities are the most frequent toxic manifestation of 5-fluorouracil (5-Fu) action in cancer patients. Hence, new approaches are required to deter chemotherapy-induced kidney toxicity. Nigella sativa (NS) is recognized as black cumin and has been found to be antiapoptotic, antioxidant, antimicrobial, anti-inflammatory and mitigates renal damage. Objectives: Thus, designed this work to evaluate the effect of NS in averting Nephrotoxicity induced by 5-FU 5-FU, p38MAPK pathway, Inflammation, Oxidative stress, ROS, Nigella sativa https://www.ijper.org/the-hyperglycemic-and-anti-hyperlipidemic-properties-of-honeybee-mixed-with-whea 2026-04-28T07:27:36.71082+00:00 The Hyperglycemic and Anti-hyperlipidemic Properties of Honeybee Mixed with Wheat Germ in Streptozotocin-induced Diabetes in Rats 2024-12-20 10.5530/ijper.58.1.23 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-212.pdf Aim: This study aimed to find out the impacts of a honeybee and Wheat Germ (WG) combination on blood glucose and cholesterol concentrations in diabetic rats when administered orally. Materials and Methods: Thirty-eight male Sprague Dawley rats were divided into normal (n=8) and diabetic (n=30). The second group was injected with streptozotocin (at a dose of 75 mg/ kg intraperitoneally), and those with blood glucose concentrations more than 250 mg/dL were classified as diabetic. Rats were divided Functional Food, Glucose, HbA1c, Cholesterol, LDL, Metformin https://www.ijper.org/stability-indicating-method-development-and-validation-for-the-simultaneous-esti 2026-04-28T07:26:54.354039+00:00 Stability Indicating Method Development and Validation for the Simultaneous Estimation of Azilsartan and Chlorthalidone in their Bulk and Pharmaceutical Dosage Forms by RP-UPLC 2024-12-20 10.5530/ijper.58.1.32 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-297.pdf Aim: The present study is aimed towards developing and validating novel RP-UPLC analytical method for the analysis of Azilsartan and Chlorthalidone in their pharmaceutical formulations and to carry out stability studies by forced degradation to ascertain the stability of selected drugs. The proposed method was challenging as the method used in the study is novel for the estimation of antihypertensive drugs. Materials and Methods: The solubility studies of Azilsartan and Chlorthalidone were carri Liquid Chromatography, Azilsartan, Forced degradation, Validation, Chlorthalidone https://www.ijper.org/self-nanoemulsifying-isotretinoin-topical-formulation-development-optimization-a 2026-04-28T07:28:53.128639+00:00 Self-Nanoemulsifying Isotretinoin Topical Formulation: Development, Optimization and Characterization, in vitro Permeation Study by Using Response Surface Methodology 2024-12-20 10.5530/ijper.58.1.12 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-122.pdf Aim/Background: The objective of this research was to develop a nano-emulsified formulation by using a central composite design for topical drug delivery. Materials and Methods: Isotretinoin-loaded nano-emulsified drug delivery system was prepared for topical application. Surface response methodology was used for the Design Of Experiment (DOE) using Central Composite Design (CCD). A combination of roseship and soyabean oil was used as the oil phase for the development of the formulation. Kolliph Isotretinoin, Photostability, Solubility, in vitro drug Permeation https://www.ijper.org/IndJPhaEdRes-58-1-187 2026-04-28T07:27:58.639199+00:00 Anti-snakevenom Activity of Mesua ferrea Linn. against the Venom of Saw Scaled Viper (Echis carinatus) 2024-12-20 10.5530/ijper.58.1.20 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-187.pdf Background: Traditionally Mesua ferrea Linn. used in ethnomedicine for the treatment of various diseases, The leaves and flower are uses as antidote for snake poisoning. The anti-snakevenom activity has not yet reported scientifically. Objectives: The designed study is to proof the anti-snakevenom potential of the leaves of aqueous alcoholic extract of Mesua ferrea Linn. by in vitro enzymatic inhibition followed by neutralization and anti-haemorhagic potential against the venom Echis carinatus b Mesua ferrea Linn, Anti-snakevenom, Saw scaled viper, Echis carinatus, Neutralization, potential https://www.ijper.org/evaluation-of-the-knowledge-attitude-and-public-awareness-about-the-use-of-antib 2026-04-28T07:26:44.231972+00:00 Evaluation of the Knowledge, Attitude and Public Awareness about the Use of Antibiotics and Antibiotic Resistance in Albania 2024-12-20 10.5530/ijper.58.1.34 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-316.pdf Aim: Antibiotic-Resistance remains a major risk to the general public's health. To assess public awareness about antibiotics usage and antibiotic resistance, survey-based research was conducted during October-December 2022 in Tirana, Albania. The aim of this research is to analyze the general public's level of knowledge and awareness of antibiotic use and resistance to antibiotics as well as to identify the demographic traits associated with them. Materials and Methods: A validated survey was us Antibiotics, Antibiotic Resistance, Knowledge, Awareness https://www.ijper.org/assessment-of-health-related-quality-of-life-and-associated-factors-among-type-2 2026-04-28T07:26:39.169442+00:00 Assessment of Health-Related Quality of Life and Associated Factors among Type 2 Diabetes Mellitus Patients Attending a Tertiary Care Hospital 2024-12-20 10.5530/ijper.58.1.35 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-326.pdf Background: Type 2 diabetes mellitus is a chronic disease that can affect the quality of life of individuals. Health-Related Quality of Life (HRQOL) is an important outcome measure in assessing the impact of diabetes on individuals' lives. This study aimed to assess the HRQOL of individuals with type 2 diabetes in India using the SF-36 questionnaire, identify factors associated with HRQOL, and evaluate the overall QOL of this population. Materials and Methods: In this study, 300 individuals with Diabetes Mellitus, Quality of life, Type 2 DM, Factors, Clinical Pharmacy, Clinical, Pharmacist https://www.ijper.org/risk-of-respiratory-diseases-with-use-of-psychotropic-drugs-results-of-a-communi 2026-04-28T07:26:32.8584+00:00 Risk of Respiratory Diseases with Use of Psychotropic Drugs: Results of a Community-based Cross-sectional Study from South India 2024-12-20 10.5530/ijper.58.1.36 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-333.pdf Background: The study evaluated the effect of various psychotropics on pulmonary function to identify the psychotropic drug class most commonly associated with risk of respiratory disorders. Since psychotropic medications have safety concerns for usage in general population, their use in people with Coronavirus Disease (COVID-19) is considered challenging. The study may also serve to draw evidence-based practical recommendations for the treatment of people with COVID-19. Materials and Methods: A Psychotropic, Anti-psychotics, Respiratory disorder, Pneumonia, COVID-19 https://www.ijper.org/the-traditional-uses-phytochemistry-and-pharmacological-effects-of-clitoria-tern 2026-04-28T07:16:43.924878+00:00 The Traditional Uses, Phytochemistry, and Pharmacological Effects of Clitoria ternatea: A Review 2024-12-20 10.5530/ijper.58.1.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-001.pdf Clitoria ternatea (Family: Fabaceae) is an important medicinal plant in traditional folk medicine. This plant was found to contain various types of metabolites. Many different pharmacological effects, including antioxidant protection from illness, have been attributed to the plant's wide range of phytochemical constituents. This article provides an overview of the current phytochemical and pharmacological research as well as the traditional and medical applications of this plant. The significant Clitoria ternatea, Butter pea flower, Extract, Biological activity https://www.ijper.org/a-case-report-of-retracted-publications-in-pharmaceutical-science-as-a-remedy-fo 2026-04-28T07:26:16.571611+00:00 A Case Report of Retracted Publications in Pharmaceutical Science as a Remedy for Research Malpractice 2024-12-20 10.5530/ijper.58.1.40 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-364.pdf Background: The number of retractions of journal articles has sharply increased in recent decades. Objectives: In this case report, excessive retracted publications on the anti-cancer properties of physcion 8-O-β-D-glucopyranoside (PG) in recent years were presented and discussed, in comparison with those of physcion. A literature search for technical and review papers on the anti-cancer properties of PG and physcion was conducted via Google Scholar and PubMed. PG and physcion are bioactive anth Physcion, Physcion 8-O-β-D-glucopyranoside, Anthraquinones, Retraction, Anti-cancer properties https://www.ijper.org/identification-of-suitable-amalgamation-with-resveratrol-epigallocatechin-3-gall 2026-04-28T07:28:02.171706+00:00 Identification of Suitable Amalgamation with Resveratrol, Epigallocatechin-3-gallate, and Diallyl Trisulfide against Skin Cancer Cell Lines (A431) 2024-12-20 10.5530/ijper.58.1.19 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-178.pdf Introduction: Resveratrol, Epigallocatechin -3-gallate (EGCG) and Diallyl Trisulfide (DATS) are bioactive compounds in which two polyphenols and an organosulfur are naturally occurring bioactive chemicals that can be efficacious in skin cancer chemoprevention either independently or in combination. Objectives: Conglomerate analysis of RES, EGCG, and DATS was performed as a single and in binary combinations to investigate cancer cell viability, in vitro in the A431 (human epidermoid carcinoma) sk Skin cancer, Synergistic effect of Resveratrol, Epigallocatechin-3-gallate, Diallyl, trisulfide, Dietary bioactive compound https://www.ijper.org/anti-asthmatic-and-immunomodulatory-effect-of-actinidia-deliciosa-fruit-on-swiss 2026-04-28T07:28:13.180357+00:00 Anti-Asthmatic and Immunomodulatory Effect of Actinidia deliciosa Fruit on Swiss Albino Mice 2024-12-20 10.5530/ijper.58.1.17 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-162.pdf Aim: The aim of the current research is the evaluation of immunomodulatory and anti-asthmatic activity of Actinidia deliciosa on Swiss albino mice by using a number of experimental models. Materials and Methods: The immunomodulatory and anti-asthmatic activity of Actinidia deliciosa in Swiss albino mice was evaluate by using models like delayed type hypersensitivity, neutrophil adhesion test, milk induced neutrophil leucocytes in mice, clonidine induced catalepsy activity in mice, clonidine indu Immunomodulatory, Anti-asthmatic, Actinidia deliciosa, Neutrophils, Degranulation https://www.ijper.org/chrysanthemum-coronarium-l-chemical-composition-and-gastroprotective-potential-o 2026-04-28T07:28:21.724257+00:00 Chrysanthemum coronarium L: Chemical Composition and Gastroprotective Potential of Methanolic Leaf Extract in Ethanol-induced Gastric Ulcers in Male Wistar Rats 2024-12-20 10.5530/ijper.58.1.15 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-145.pdf Background: Our study evaluated the effect of Chrysanthemum coronarium L. (CC) leaves on ethanol-induced acute gastric ulcers in Wistar rats. Materials and Methods: The organic extract of CC was obtained by Soxhlet extraction with methanol and then divided into two dose groups: 250 mg/kg and 500 mg/kg. Omeprazole was used as a positive control at 20 mg/ kg. Our extract was subjected to the separation of bioactive compounds by High-Performance Liquid Chromatography (HPLC). Lethality tests (LD50) Chrysanthemum coronarium L, Hplc, LD50, Ethanol, Gastric ulcer, Rat https://www.ijper.org/silver-nanoparticles-incorporated-chitosan-hydrogel-as-a-potential-dressing-mate 2026-04-28T07:28:29.220633+00:00 Silver Nanoparticles Incorporated Chitosan Hydrogel as a Potential Dressing Material for Diabetic Wound Healing in Nursing Care 2024-12-20 10.5530/ijper.58.1.14 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-139.pdf Background: Nursing care of diabetic wounds remains a significant challenge due to a variety of reasons including low blood flow, impaired activity of inflammatory responses, and high oxidative stress in the diabetic wounds bed. Materials and Methods: In the current research, silver Nanoparticles (AgNPs) were loaded into a chitosan hydrogel system to produce a potential wound dressing for treating diabetic wounds. Various in vitro studies such as scanning electron microscopy assay, cell viabilit Wound nursing care, Silver nanoparticles, Chitosan hydrogel, Drug delivery, Wound, dressing https://www.ijper.org/ursolic-acid-loaded-transniosomes-nanogel-for-topical-delivery-statistical-optim 2026-04-28T07:28:57.392186+00:00 Ursolic Acid Loaded Transniosomes Nanogel for Topical Delivery: Statistical Optimization with Box-Behnken Design of Quality by Design (QbD), in vitro and Dermatokinetic Evaluation 2024-12-20 10.5530/ijper.58.1.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-109.pdf Aim: The current research was performed for the preparation and optimization of Transniosomes (TN) preparation for the dermic distribution of Ursolic Acid (UA). Materials and Methods: The formulation was optimized by using the “Box–Behnken design” software. Particles size, % EE, and in vitro study was performed for the optimal formulations after they had been optimised. In addition, morphological, CLSM and dermatocokinetic studies were performed in order to complete the evaluation of the optimal Ursolic acid, Dermal, Confocal laser scanning microscopy, Dermatokinetic, Skin, cancer, Transniosomes, Tumors https://www.ijper.org/nanostructured-lipid-carriers-a-potential-era-of-drug-delivery-systems 2026-04-28T07:17:14.617504+00:00 Nanostructured Lipid Carriers: A Potential Era of Drug Delivery Systems 2024-12-20 10.5530/ijper.58.1.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-021.pdf Nanotechnology is rapidly evolving in the development of new drug delivery systems. Nanostructured lipid carriers are the second era of Solid Lipid Nanoparticles (SLN). These are the alternative carrier system over the solid lipid nanoparticles. Nanostructured lipid carriers are composed of a mixture of solid and liquid lipids, resulting in a solely crystallized lipid system with various advantages over solid lipid nanoparticles, such as higher drug entrapment efficiency, drug release modificati Nanostructured lipid carriers, Nanotechnology, Biocompatibility, Lipid nanocarriers https://www.ijper.org/formulation-optimization-and-characterization-of-plga-chitosan-nanoparticles-con 2026-04-28T07:29:02.50919+00:00 Formulation, Optimization and Characterization of PLGA-Chitosan Nanoparticles Containing Vinorelbine Ditartrate 2024-12-20 10.5530/ijper.58.1.10 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-099.pdf Background: The prime objective of our investigation was to optimize PLGA-chitosan nanoparticles containing vinorelbine ditartrate. Materials and Methods: The Vinorelbine ditartrate nanoparticles were formulated using emulsion method followed by probe sonication to reduce the size. A three factor three level Box-Behnken Design has been implemented to optimize chitosan, Poloxamer 188 and sonication time (independent variables) for particle size, polydispersity index and entrapment efficiency (%) Nanoparticles, Vinorelbine ditartrate, Particle size, Optimization, in vitro drug release https://www.ijper.org/fabrication-and-evaluation-of-poloxamer-facilitated-glyceryl-monooleate-based-5 2026-04-28T07:29:07.340117+00:00 Fabrication and Evaluation of Poloxamer Facilitated, Glyceryl Monooleate based 5-Fluorouracil Cubosomes 2024-12-20 10.5530/ijper.58.1.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-091.pdf Objectives: This study aims to prepare a topical cubosomal formulation that contains 5-Fluorouracil (5-FU), a hydrophilic anti-cancer drug, that belongs to the Biopharmaceutics Classification System (BCS-III) i.e., high solubility and low permeability. Materials and Methods: The 5-FU loaded cubosomes were prepared using Glyceryl Monooleate (GMO) as a lipid polymer, in the presence of Poloxamer 407 (Polox-407) and Tween 80 (T80) as stabilizers. Four formulations of cubosomes were formulated by va Cubosomes, Permeation, Drug release, Thermal analysis https://www.ijper.org/amelioration-of-lipid-metabolic-profiles-by-trigonelline-a-bioactive-compound-of 2026-04-28T07:28:06.030195+00:00 Amelioration of Lipid Metabolic Profiles by Trigonelline a Bioactive Compound of Trigonella Foenum-graecum in Alcohol Induced Albino Rats 2024-12-20 10.5530/ijper.58.1.18 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-172.pdf Aim: Alcoholism leads to heart diseases, lung diseases and liver disorders. Alcoholism impairs heart homeostasis and causes cardio vascular diseases. The current investigation was carried out to know the hypolipidemic effect of Trigonelline (TG) a bioactive compound of Trigonella foenum-graecum (TGf) in alcohol intoxicated rats. Materials and Methods: The rats were randomized into five groups and treatment was given as per the experimental protocol. The lipid metabolic profiles like Malondialdeh Alcoholism, Lipid metabolic profiles, Trigonelline, Rats https://www.ijper.org/histopathological-and-biochemical-investigation-of-the-effect-of-shepherds-purse 2026-04-28T07:27:54.629329+00:00 Histopathological and Biochemical Investigation of the Effect of Shepherd's Purse (Capsella bursa-pastoris L.) on Ethanol-Induced Liver Damage 2024-12-20 10.5530/ijper.58.1.21 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-198.pdf Background: The aim of the present study was to investigate the hepatoprotective effect of Shepherd's Purse (SP) herbal tea on ethanol (EtOH)-induced liver toxicity. Materials and Methods: Male Wistar rats (n = 32) were divided into 4 experimental groups: control, EtOH (30% EtOH), EtOH+SP (30% EtOH+1 mL/kg SP), and SP (1 mL/kg SP orally). EtOH and SP were administered by orogastric gavage once daily. At the end of the 60-day experimental period, tissue and blood samples were obtained from the ra Shepherd's purse, Ethanol, Histopathology, Liver, Rat https://www.ijper.org/troxerutin-exerts-anti-pulmonary-fibrosis-activity-in-nicotine-induced-lung-fibr 2026-04-28T07:27:12.574892+00:00 Troxerutin Exerts Anti-Pulmonary Fibrosis Activity in Nicotine-Induced Lung Fibrosis on Zebra Fish Model 2024-12-20 10.5530/ijper.58.1.28 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-263.pdf Background: Cigarette smoking is the major obstacles to lung cell proteostatic imbalance due to the exposure of the respiratory epithelial cell to toxic oxidants. The most active ingredient presents in the cigarette smokers, nicotine causes number of health risk by synthesis of free radicals which alters the individual cell DNA stability. Troxerutin, a flavonoid derived from the Rutin, possess antioxidant potential which has been investigated for its anti-pulmonary fibrosis activity against nico Nicotine, Zebra fish, Antioxidant, Troxerutin, Lipid peroxidation, Gene expression https://www.ijper.org/uvaol-inhibits-inflammatory-response-and-prevents-lipopolysaccharide-induced-acu 2026-04-28T07:27:08.244619+00:00 Uvaol Inhibits Inflammatory Response and Prevents Lipopolysaccharide-Induced Acute Lung Injury in Mice 2024-12-20 10.5530/ijper.58.1.29 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-271.pdf Background: Sepsis is a clinical disease characterized by systemic inflammatory reactions following infection that can lead to multiorgan failure. Acute Lung Injury (ALI) is a common ailment with increased morbidity and fatality rates worldwide. Objectives: The present investigation was planned to investigate the salutary activities of uvaol against Lipopolysaccharide (LPS)-exposed ALI in mice. Materials and Methods: The 5 mg/kg of LPS was exposed to the mice for 3 days through the intra-trachea Lipopolysaccharide, Cytokines, Apoptosis, Uvaol, Lung edema, Sepsis https://www.ijper.org/design-and-characterization-of-ph-dependent-phase-transition-system-of-almotript 2026-04-28T07:29:11.466853+00:00 Design and Characterization of pH Dependent Phase Transition System of Almotriptan Malate for Nasal Drug Delivery System by Employing Factorial Design 2024-12-20 10.5530/ijper.58.1.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-076.pdf Introduction: Nasal medication delivery uses nasal mucosa for faster and higher drug absorption. Transmucosal nasal administration is promising. Many medicines obtain superior systemic absorption via nasal route than orally. Objectives: This research aimed to construct and characterize a pH-dependent almotriptan malate nasal in situ gel for acute migraine treatment. It eases discomfort, headaches, and migraine symptoms. Materials and Methods: Gels were delivered by changing the grouping of pH-se In situ Gel, Migraine, Triptan, pH Sensitive, Nasal Gel, Almotriptan Malate https://www.ijper.org/protective-effects-of-hibiscetin-on-ethanol-induced-ulcers-in-rats-through-inhib 2026-04-28T07:27:03.532648+00:00 Protective Effects of Hibiscetin on Ethanol-Induced Ulcers in Rats through Inhibition of Prostaglandin Synthesis/ Oxidative Stress/Caspase-3 and 9 Pathways 2024-12-20 10.5530/ijper.58.1.30 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-280.pdf Aim/Background: Ethanol (EtOH)-induced gastric ulcers are a prevalent gastrointestinal disorder characterized by severe inflammation, oxidative stress, and apoptotic cell death. This study aimed to investigate the potential protective effects of hibiscetin against EtOH-induced ulcers in rats. Materials and Methods: Rats were randomly divided into five groups: Normal control (normal saline), EtOH (1.5 mL), hibiscetin 10 mg/kg + EtOH, hibiscetin 20 mg/kg + EtOH, and hibiscetin 20 mg/kg alone (cont Antioxidant enzymes, Ethanol, Hibiscetin, Ulcer, Pro-inflammatory cytokines https://www.ijper.org/assessment-of-the-quality-of-education-received-by-undergraduate-pharmacy-studen 2026-04-28T07:29:15.787472+00:00 Assessment of the Quality of Education Received by Undergraduate Pharmacy Students in Selected Universities in Nigeria 2024-12-20 10.5530/ijper.58.1.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-069.pdf Background: To assess the self-reported quality of education received by undergraduate pharmacy students and to explore factors influencing career choice. Materials and Methods: A pretested questionnaire was administered to a convenient sample of 2090 pharmacy students in their professional years from selected universities in Nigeria. Respondent’s characteristics and responses were reported as simple proportions and percentages. Results: The response rate was 71%. Only 1028 (69.3%) originally in Undergraduate students, Pharmacy education, Career choices, Nigeria https://www.ijper.org/research-progress-of-baicalin-interactions-with-the-animal-gut-microbiome 2026-04-28T07:29:21.889787+00:00 Research Progress of Baicalin Interactions with the Animal Gut Microbiome 2024-12-20 10.5530/ijper.58.1.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-064.pdf Homeostasis of the animal gut microbiome is essential for maintaining intestinal health and normal growth and development. Baicalin is an O-glucuronidated flavonoid that possesses strong anti-bacterial, anti-inflammatory and antioxidant activities. Its addition to animal feed can alter gut microbial community composition, diversity and production of bacterial metabolites while decreasing production of pro-inflammatory cytokines and other factors that compromise the integrity of the epithelial ce Baicalin, Gut microbiota, Mechanism, Intervention treatment, Intervention, environment, Function, Structure https://www.ijper.org/liposomal-cosmeceuticals-as-skin-protectives-and-curatives 2026-04-28T07:29:30.69938+00:00 Liposomal Cosmeceuticals as Skin Protectives and Curatives 2024-12-20 10.5530/ijper.58.1.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-034.pdf Lifestyles and environmental changes draw people away from healthy and natural-looking skin. To hide the impaired and damaged skin texture as a result of several factors, people mostly prefer decorative cosmetics to get an immediate but temporary result. To overcome this problem, cosmeceuticals are emerged containing skin-protective and curative agents in a cosmetic base. The market is full of skincare products and many of them have proven unsatisfactory to the consumer. Liposome, a novel lipoid Cosmeceutical, Skin care, Skin protective, Curative, Liposomes https://www.ijper.org/spectrophotometric-absorption-correction-methods-for-the-estimation-of-fixed-dos 2026-04-28T07:26:59.26655+00:00 Spectrophotometric Absorption Correction Methods for the Estimation of Fixed-Dose Combinations of Dapagliflozin and Metformin Hydrochloride 2024-12-20 10.5530/ijper.58.1.31 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-291.pdf Background: For the assessment of fixed-dose combinations of Dapagliflozin and Metformin Hydrochloride in bulk pharmaceuticals and pharmaceutical formulations utilizing distilled water as a solvent, a novel, straightforward, precise, and accurate UV-spectrophotometric absorbance correction approach was devised. On the additive absorbance property, an absorbance correction method was based. Materials and Methods: By keeping Dapagliflozin and Metformin hydrochloride apart, a distinct spectrum was Dapagliflozin, Metformin hydrochloride, Absorbance correction method, Method, validation https://www.ijper.org/a-questionnaire-based-study-on-the-use-of-weight-loss-medicines-and-herbal-mixtu 2026-04-28T07:26:26.473874+00:00 A Questionnaire-Based Study on the Use of Weight-Loss Medicines and Herbal Mixtures among Pharmacy Students in the Hail Region 2024-12-20 10.5530/ijper.58.1.37 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-342.pdf Objectives: The obesity epidemic continues to grow at an alarming rate because the lifestyle we live plays a big role in the continuation and exacerbation of this problem. The use of medicines and herbs has become widespread, especially among young people. This study's objective was to identify the medicines and herbs used to treat obesity specifically among pharmacy female students in Hail city. Materials and Methods: An online, semi-structured questionnaire was used to collect data, and the re Obesity, Weight loss medications, Herbal mixtures, Pharmacy Female students, Hail, City https://www.ijper.org/the-comparative-analysis-of-the-impact-of-n-acetyl-l-cysteine-and-its-combinatio 2026-04-28T07:26:21.785944+00:00 The Comparative Analysis of the Impact of N-Acetyl-L-Cysteine and its Combination with Propolis on Quality-of-Life in Patients with Acute Bronchitis 2024-12-20 10.5530/ijper.58.1.38 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-348.pdf Objectives: Evidence suggests that both N-Acetyl-L-cysteine (NAC) and NAC in combination with propolis (NAC-P) reduce symptoms of acute bronchitis and improve Health-Related Quality of Life (HRQoL). This study aimed to compare the impact of NAC and NAC-P therapy on acute bronchitis patients' quality of life. Design, setting, and subjects: A randomized, single-blind parallel-group study was achieved at Municipal Institute for Lung Diseases and Tuberculosis Medical Centre, Belgrade, Serbia. Patien Respiratory disease, Bronchitis, Health-Related Quality of Life, N-Acetyl-L-cysteine, Propolis, Treatment https://www.ijper.org/a-novel-approach-on-micro-sponges-drug-delivery-system-method-of-preparations-ap 2026-04-28T07:29:26.551303+00:00 A Novel Approach on Micro Sponges Drug Delivery System: Method of Preparations, Application, and its Future Prospective 2024-12-20 10.5530/ijper.58.1.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1-045.pdf Microsponges are porous microspheres ranging in size from 5 to 300 micrometers used in a polymeric delivery system. They have been studied for biomedical applications, including targeted medicine delivery, transdermal drug delivery, anticancer drug delivery, and bone substitutes. This research aims to conduct a detailed examination of existing trends and future prospects for a microsponge-based medicine delivery system. The current study investigates the Microsponge Delivery System's design, ope Microsponge, Microsponge delivery system, Novel drug delivery system, Quasi, emulsion solvent diffusion, Vibrating orifice aerosol generator, Electrohydrodynamic atomization https://www.ijper.org/effects-of-foliar-application-of-chitosan-on-some-vegetative-growth-and-biochemi 2026-04-13T05:54:07.933096+00:00 Effects of Foliar Application of Chitosan on Some Vegetative Growth and Biochemical Parameters of Strawberry Under Salt Stress 2024-11-19 10.5530/ijper.58.4s.149 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4s-1242.pdf Aim/Background: This research, which was carried out as a pot experiment in a plastic greenhouse to examine the effects of three different salt (NaCl) doses (Control, 30, 60 mmol/L) and three different chitosan doses (Control, 1, 2 and 3 ppm) applied to Albion strawberry variety (Fragaria ananassa Duch.). Materials and Methods: In this study, plant characteristics such as leaf area, Fresh Weight (FW) and Dry Weight (DW) of root, crown and leaf were investigated. Biochemical parameters including Strawberry (Fragaria ananassa), Chitosan, Salt Stress, Phenolic Compound, Vegetative, Growth https://www.ijper.org/question-paper-design-in-line-with-outcome-based-education-policy 2026-04-13T05:54:07.933096+00:00 Question Paper Design in Line with Outcome-Based Education Policy 2024-11-19 10.5530/ijper.58.4s.117 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4s-1201.pdf Outcome-Based Education (OBE) is an educational framework that focuses on achieving specific, measurable outcomes in terms of student learning and performance. Unlike traditional education models that emphasize content delivery and time-based progression, OBE starts with the end goals-what students should know, are able to do and be able to demonstrate after they complete a program. These outcomes are clearly defined and serve as the foundation for curriculum design, teaching methods and assessm Assessment, Learning Outcomes, Outcome Based Education, Question Paper, Teaching-Learning https://www.ijper.org/bioactivities-biopharmaceutics-and-advanced-drug-delivery-systems-of-magnolol 2026-04-13T05:54:07.933096+00:00 Bioactivities, Biopharmaceutics, and Advanced Drug Delivery Systems of Magnolol 2024-11-19 10.5530/ijper.58.4s.110 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4s-1108.pdf Magnolia bark is an important food supplement. Magnolol (ML), 3,3′-Neoligna-8,8′-diene-4,4′- diol, is a bioactive phenolic molecule found in the Magnolia family. Advanced Drug Delivery Systems (DDSs) have been able to enhance therapeutic efficacy and reduce adverse effects of plant-derived bioactive. In the first part of the review, the bioactivities, mechanisms, and clinical prospects of ML are described. A brief explanation of the mechanisms of anti-inflammatory, antioxidant, cardiovascular-pr Biopharmaceutics, Drug delivery, Magnolol, Nanostructure, Pharmacokinetics https://www.ijper.org/spray-dried-nanoparticle-for-pulmonary-delivery-current-developments-and-future 2026-04-13T05:54:07.933096+00:00 Spray Dried Nanoparticle for Pulmonary Delivery: Current Developments and Future Perspectives 2024-11-19 10.5530/ijper.58.4s.114 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4s-1156.pdf Aim: The study aims to comprehensively review advancements in spray-dried nanoparticles for pulmonary drug delivery. It focuses on understanding current techniques, nanoparticle types and applications. Additionally, it aims to identify challenges, assess developments critically and propose future perspectives. The research explores strategies to enhance nanoparticle efficiency, safety and targeted lung delivery. The ultimate goal is to provide valuable insights guiding researchers, pharmaceutica Dry powder inhaler, pulmonary drug delivery, spray drying, drug nanoparticle https://www.ijper.org/enhanced-antifungal-efficacy-of-transferosomal-gel-containing-clotrimazole-and-m 2026-04-13T05:54:07.933096+00:00 Enhanced Antifungal Efficacy of Transferosomal Gel Containing Clotrimazole and Miconazole Nitrate: A Novel Approach for Topical Treatment by QbD 2024-11-19 10.5530/ijper.58.4s.118 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4s-1211.pdf Aim: This study focuses on developing and evaluating a transferosomal gel containing clotrimazole and miconazole nitrate, antifungal medications used to treat fungal infections, including superficial tinea and nail infections. Materials and Methods: The MI-CTM transferosomes were created using rotary film evaporation and optimized using the Box-Behnken statistical design. They were evaluated for drug concentration, viscosity, Spreadability, pH, and in vitro release kinetics after being embedded Transferosomes, Transdermal drug delivery system, Antifungal, Drug release https://www.ijper.org/nanotechnology-driven-approaches-in-overcoming-drug-delivery-challenges-for-neur 2026-04-13T05:54:07.933096+00:00 Nanotechnology-Driven Approaches in Overcoming Drug Delivery Challenges for Neurodegenerative Diseases 2024-11-19 10.5530/ijper.58.4s.116 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4s-1185.pdf The management of Neurodegenerative Diseases (NDs) is a substantial concern for healthcare systems at present. Alzheimer’s disease, frontotemporal dementia, Parkinson’s disease, prion disease, Huntington’s disease and Amyotrophic lateral sclerosis are among these conditions. Pathogenic characteristics shared by these conditions include increased oxidative stress, misfolded proteins, dysfunctional mitochondria, excitotoxicity and neuro inflammation; these ultimately result in the deterioration of Alzheimer’s disease, Drug delivery, Frontotemporal dementia, Neurodegenerative, diseases, Parkinson’s disease, Nanotechnology https://www.ijper.org/an-albumin-based-amygdalin-glutaraldehyde-nanoparticle-induces-apoptosis-in-oral 2026-04-13T05:54:07.933096+00:00 An Albumin-Based Amygdalin-Glutaraldehyde Nanoparticle Induces Apoptosis in Oral Cancer KB Cells 2024-11-19 10.5530/ijper.58.4s.122 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4s-1271.pdf Background: There is potential for nanotechnology to address the drawbacks associated with conventional cancer therapies. The current study was undertaken to formulate amygdalin-functionalized Albumin-Glutaraldehyde Nanoparticles (AAG-NPs) and evaluate their antimicrobial and anticancer properties against oral cancer KB cells. Materials and Methods: The AAG-NPs were synthesized and characterized using UV-visible spectroscopy, XRD, SEM, TEM, DLS, FT-IR and PL analyses. The well diffusion techniqu Amygdalin, Oral cancer, Albumin, Apoptosis, KB cells https://www.ijper.org/a-validated-lc-msms-method-for-determination-at-trace-level-of-nitrosamine-impur 2026-04-13T05:54:07.933096+00:00 A Validated LC-MS/MS Method for Determination at Trace Level of Nitrosamine Impurities in Doxofylline API 2024-11-19 10.5530/ijper.58.4s.121 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4s-1262.pdf Background: The FDA looked at popular amine-based API synthesis processes and found that these processes might additionally introduce nitrosamine-hazardous substances. The current method describes trace-level quantification of Nitrosamine impurities (NDEA, NDIPA, NDIPA, NEIPA, NMPA, NDBA, NDMA and NMBA) in the Doxofylline API. Materials and Methods: With the help of Waters® ACQUITY® UPLC BEH C18 (150x4.6 mm, 5 μm) and a 0.8 mL/min flow, a gradient programme (0.1%v/v formic acid and methanol) con NDMA, Doxofylline, NDEA, Nitrosamine impurities, APCI https://www.ijper.org/impact-of-dietary-supplements-in-alleviating-human-lifestyle-and-their-regulator 2026-04-13T05:54:07.933096+00:00 Impact of Dietary Supplements in Alleviating Human Lifestyle and their Regulatory Aspects 2024-11-19 10.5530/ijper.58.4s.112 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4s-1128.pdf Dietary supplements generally items which have the goal of boosting the person's wellness and general well-being and are often ingested at mealtime or in scheduled times in order to improve a person's dietary routine. Once an individual has a nutritional unbalance or as a shortage of certain nutrients, supplementation needs to be taken. Classes of dietary supplements include Vitamins, Minerals, Proteins, Multivitamins, Multiminerals, Herbs, Carbohydrates, hormone activators and oil supplements a Dietary supplements, Effectiveness, Regulatory approval, Toxicity, Quality, Food, products https://www.ijper.org/immune-checkpoint-inhibitors-for-cancer-therapy-status-and-future-directions 2026-04-13T05:54:07.933096+00:00 Immune Checkpoint Inhibitors for Cancer Therapy: Status and Future Directions 2024-11-19 10.5530/ijper.58.4s.115 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4s-1169.pdf Among various treatment modalities available for the treatment of cancer, immunotherapy is one of the important strategies used for the management of different malignancies. Immune checkpoint inhibitors are used for the treatment of cancers based on immunotherapy. Immune checkpoints are implicated when the proteins on the immune cells identify and bind to the ligand on the surface of other cells. These proteins are referred as immune checkpoint proteins. As soon as the checkpoint protein and lig Immune checkpoint inhibitors, PD-1, PD-L1, Cancer, Immunotherapy https://www.ijper.org/evaluation-of-cardiac-myosin-binding-protein-c3-cmybp-c3-as-potential-risk-facto 2026-04-13T05:54:07.933096+00:00 Evaluation of Cardiac Myosin Binding Protein-C3 (cMyBP-C3) as Potential Risk Factor of Acute Coronary Syndrome in Diabetic Patients 2024-11-19 10.5530/ijper.58.4s.120 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4s-1234.pdf Background: Recent years, the prevalence of Type 2 Diabetes Mellitus (T2DM) has increased annually. The major complication of T2DM is Cardiovascular Disease (CVD). Cardiovascular disease is the main cause of death in T2DM patients, particularly those with comorbid Acute Coronary Syndrome (ACS). The present study aims to determine the cardiac Myosin Binding Protein-C3 (cMyBP-C3) levels in patients with Type 2 Diabetes Mellitus (T2DM) and to examine the relation of cMyBP-C3 levels with the Acute C cMyBP-C3, Type 2 diabetes, HbA1c, Acute Coronary Syndrome, Cardiac complications, of diabetes https://www.ijper.org/critical-review-of-risk-assessment-tools-in-pharmaceutical-quality-by-design 2026-04-13T05:54:07.933096+00:00 Critical Review of Risk Assessment Tools in Pharmaceutical Quality by Design 2024-11-19 10.5530/ijper.58.4s.113 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4s-1145.pdf Pharmaceutical Quality by Design is a systematic approach to product development that starts with specified objectives and emphasizes product knowledge, methodologies, and operational procedures. It is based on trustworthy science and excellent risk reduction. Risk analysis is a beneficial science-based approach that may assist in discovering the material properties and production variables that may have an impact on the critical quality attributes of the finished product when it comes to high-q Quality by design, Risk assessment, Risk management, Pharmaceutical, Risk control, Failure mode https://www.ijper.org/greenness-and-whiteness-assessed-mathematically-filtered-uv-spectroscopic-approa 2026-04-13T05:54:07.933096+00:00 Greenness and Whiteness Assessed Mathematically Filtered UV Spectroscopic Approaches for Quality Control of Amlodipine, Telmisartan and Metoprolol from Ternary Formulation 2024-11-19 10.5530/ijper.58.4s.148 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4s-1250.pdf Background: Latest studies highlight the effectiveness of a new combination tablet that contains Amlodipine (AML), Telmisartan (TEL), and Metoprolol (MET) for the treatment of hypertension. The present work demonstrates the establishment of efficient and environmentally friendly sensitivity-enhanced UV spectroscopic approaches for the concomitant assessment of tablet preparations of AML, TEL, and MET. Materials and Methods: In order to disentangle the complex ternary mixture, the double devisor Hypertension, Amlodipine, Telmisartan, Metoprolol, UV-derivative spectroscopy, Greenness https://www.ijper.org/pharmacokinetic-profile-of-bioanalytical-method-development-and-validation-of-cl 2026-04-13T05:54:07.933096+00:00 Pharmacokinetic Profile of Bioanalytical Method Development and Validation of Clarithromycin from Human Plasma by Using Liquid Chromatography Tandem Mass Spectrometer 2024-11-19 10.5530/ijper.58.4s.123 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4s-1282.pdf Aim: To develop and validate a sensitive and specific bioanalytical method for the quantification of clarithromycin in human plasma using Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS). Additionally, to characterize the pharmacokinetic profile of clarithromycin, including its Absorption, Distribution, Metabolism, and Excretion (ADME) in humans. This study aims to support the clinical application and therapeutic monitoring of clarithromycin. Background: Of this study was to develop and Pk, LCMS System, Clarithromycin, Bioavailability, Solid Phase Extraction, Protein, Precipitation https://www.ijper.org/establishment-and-validation-of-lc-msms-technique-for-pafolacianine-quantificati 2026-04-13T05:54:07.933096+00:00 Establishment and Validation of LC-MS/MS Technique for Pafolacianine Quantification in Rat Plasma, with Application to Pharmacokinetic Assessment 2024-11-19 10.5530/ijper.58.4s.119 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4s-1224.pdf Background: Establishing and validating a sensitive and accurate LC-MS method for quantifying pafolacianine in rat plasma was the primary objective of this study. Phenylalanine was used as the internal standard, and the validation procedure adhered to the protocols specified by the Food and Drug Administration of the United States. Materials and Methods: This article presents an overview of the bioanalytical LC-MS method, utilizing an Inertsil ODS column (150 mm x 4.6 mm, 3.5 μm) and an organic Pafolacianine, Phenylalanine, Pharmacokinetics, Bio-analytical, Rat plasma, LC-MS/, MS https://www.ijper.org/research-planning-statistical-analysis-ethics-and-successful-publishing 2026-04-13T05:54:07.933096+00:00 Research Planning, Statistical Analysis, Ethics, and Successful Publishing 2024-11-19 10.5530/ijper.58.4s.111 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4s-1102.pdf Novice researchers are frequently inexperienced with basic concepts of research and successful scientific publishing. To strengthen their fundamental knowledge of scientific research, we recently conducted a brainstorming symposium at the 73rd Indian Pharmaceutical Congress held in Hyderabad, India in July 2024. This report highlights the symposium's key components as well as the benefits that attendees experienced. The symposium was intended to equip faculty and postgraduate and doctorate stude Research methodology, Scientific writing, Statistics, Journal submission, Peer review, Scientific integrity https://www.ijper.org/silencing-pdcd4-mediates-tfeb-overexpression-promoting-proliferation-migration-a 2026-04-13T05:54:08.792855+00:00 Silencing PDCD4 Mediates TFEB Overexpression Promoting Proliferation, Migration and Invasion of Cervical Cancer HeLa Cells 2024-10-04 10.5530/ijper.58.4.145 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1348.pdf **Aim/Background::** Cervical cancer is a common gynecologic malignant tumor, its occurrence and development are related to genetic and environmental factors. Recent studies have shown that Programmed Cell Death 4 (PDCD4) and Transcription Factor EB (TFEB) plays crucial roles in the pathogenesis of cervical cancer. The interaction between PDCD4 and TFEB and their regulatory mechanism on cellular functions in cervical cancer have not been fully explored. **Materials and Methods::** Therefore, th Cervical Cancer, PDCD4, TFEB, Proliferation, Migration, Invasion https://www.ijper.org/the-therapeutic-effects-of-qihapingchuan-capsule-in-combination-with-triple-ther 2026-04-13T05:54:08.792855+00:00 The Therapeutic Effects of QihaPingchuan Capsule in Combination with Triple Therapy (ICS+LABA+LAMA) on Chronic Obstructive Pulmonary Disease 2024-10-04 10.5530/ijper.58.4.119 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1077.pdf **Objectives:** To explore the curative effect of QihaPingchuan Capsule combined with triple therapy [Inhaled Corticosteroid (ICS)+Long-Acting β2 receptor Agonist (LABA)+Long-Acting Anticholinergic drug (LAMA)] on Chronic Obstructive Pulmonary Disease (COPD). **Materials and Methods:** A total of 92 patients with COPD admitted to the hospital were enrolled between January 2021 and October 2022. According to the random number table method, they were divided into Group A and Group B, with 46 case QihaPingchuan Capsule, Inhaled glucocorticoid, Long-acting β2 receptor agonist, Long-acting anticholinergic drug, Chronic obstructive pulmonary disease, Pulmonary function https://www.ijper.org/standards-of-child-resistant-packaging-a-regulatory-view 2026-04-13T05:54:08.792855+00:00 Standards of Child Resistant Packaging: A Regulatory View 2024-10-04 10.5530/ijper.58.4.116 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1045.pdf **Aim:** Special packaging known as “child-resistant packaging” is intended to minimize the possibility of kids eating harmful substances. The Poison Prevention Packaging Act of 1970 confers jurisdiction to regulate this on the U.S. Consumer Product Safety Commission and amended in 1995 to include senior-friendly packaging which became effective in 1972. **Materials and Methods:** For the protection of children, regulations apply to prescription pharmaceuticals, over-the-counter medicines, inse Child-resistant packaging, Performance tests, CRP indices, Re-closable child-resistant package, Opioid dependency treatment https://www.ijper.org/berberines-therapeutic-prospects-in-parkinsons-disease-a-spotlight-on-cholestero 2026-04-13T05:54:08.792855+00:00 Berberine’s Therapeutic Prospects in Parkinson’s Disease: A Spotlight on Cholesterol Regulation for Cognitive Improvement 2024-10-04 10.5530/ijper.58.4.121 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1102.pdf **Background:** Cholesterol synthesized in astrocytes of the cerebrum plays a pivotal role in regulating hippocampal neurogenesis and cognitive function. Dysregulation of cholesterol metabolism has emerged as a key contributor to the pathogenesis of Parkinson’s disease. Elevated cholesterol levels in the brain are associated with increased oxidative stress and subsequent neurodegeneration of hippocampal pyramidal neurons, culminating in cognitive impairment. Berberine, an isoquinoline alkaloid h Parkinson’s Disease, Cognitive impairment, Dopamine, Cholesterol, Alpha-synuclein, Berberine https://www.ijper.org/design-optimization-and-in-vitro-evaluation-of-orally-disintegrating-tablets-con 2026-04-13T05:54:08.792855+00:00 Design, Optimization, and in vitro Evaluation of Orally Disintegrating Tablets Containing Amlodipine Besylate 2024-10-04 10.5530/ijper.58.4.133 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1205.pdf **Background::** In this study, it was aimed to prepare orally disintegrating tablet formulations of amlodipine besylate by applying the experimental design. **Materials and Methods::** A face-centered, central composite 32 full factorial design was applied to evaluate the effects of filler ratio (MAN: MCC; X1) and super disintegrant percentage (SSG; X2) on the critical tablet characteristics such as tensile strength (Y1), disintegration time (Y2) and dissolution rate (5th min) (Y3). **Results Amlodipine besylate, Design of experiments, Texture analyzer, Orally disintegrating tablet, Direct compression tableting https://www.ijper.org/a-cross-sectional-study-of-community-attitude-towards-herbal-products-against-he 2026-04-13T05:54:08.792855+00:00 A Cross-Sectional Study of Community Attitude towards Herbal Products against Hepatobiliary Diseases in Northern Cyprus 2024-10-04 10.5530/ijper.58.4.112 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1311.pdf **Aim::** The study in Northern Cyprus aimed to improve patient-centered care and healthcare practices by examining community perceptions of Herbal Products (HPs) for liver and biliary diseases. **Materials and Methods::** The self-administered questionnaire utilized in this cross-sectional study, which was carried out in Nicosia, Northern Cyprus from October 2021 to July 2022, allowed 446 participants to provide information on their sociodemographic characteristics and attitudes toward HPs. * Hepatobiliary diseases, Herbal products, Northern Cyprus, Hepatoprotection, Cynara scolymus, Taraxacum officinale https://www.ijper.org/a-prospective-observational-study-on-assessment-of-risk-factors-complications-an 2026-04-13T05:54:08.792855+00:00 A Prospective Observational Study on Assessment of Risk Factors, Complications and Clinical Efficacy of Hepatoprotectives and Antimicrobials in Treatment of Liver Diseases at Tertiary Care Teaching Hospital in Telangana 2024-10-04 10.5530/ijper.58.4.143 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1328.pdf **Background::** The liver serves a variety of essential purposes, making it the most important organ. Chronic liver disease (CLD) has a wide range of etiologies, including toxins, alcoholism, infections, autoimmune illnesses, and hereditary problems. Patients are initially asymptomatic, as the disease progresses, signs like jaundice, icterus, pedal oedema, and abdominal distension can be seen. Liver functioning tests are used to assess liver disease progression. Liver disease may result in prob Risk factors, Complications, Alcoholic liver diseases, Hepatoprotectives, Antimicrobials https://www.ijper.org/development-and-validation-of-a-new-rp-hplc-method-for-the-simultaneous-estimati 2026-04-13T05:54:08.792855+00:00 Development and Validation of a New RP-HPLC Method for the Simultaneous Estimation of Nirmatrelvir, Ritonavir and Molnupiravir in Formulated Nanosponges, Plasma Samples and its Pharmacokinetic Study 2024-10-04 10.5530/ijper.58.4.142 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1299.pdf **Background::** Nirmatrelvir and Ritonavir are used in combination (Paxlovid®) in order to treat COVID-19. Thus, the goal of the current study was to create an easy-to-use, accurate, and sensitive method for the preparation of nanosponges utilising High-Performance Liquid Chromatography (HPLC) to simultaneously estimate Nirmatrelvir and Ritonavir in plasma samples and prepared nanosponges. **Materials and Methods::** Nanosponges containing Nirmatrelvir and Ritonavir were prepared using ethyl-c RP-HPLC method, Nirmatrelvir, Ritonavir, Nanosponges, Paxlovid®, Simultaneous estimation, Plasma, Pharmacokinetic study, ICH Validation https://www.ijper.org/gcms-and-lcmsms-based-analysis-for-the-identification-and-characterization-of-bi 2026-04-13T05:54:08.792855+00:00 GCMS and LCMS/MS Based Analysis for the Identification and Characterization of Bioactive Metabolites of Seaweed Kappaphycus striatus as an Anti-hypertensive and Anti-hypercholesterolemic Agent 2024-10-04 10.5530/ijper.58.4.141 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1287.pdf **Background::** Over 50% of the population in Malaysia has hypercholesterolemia, which puts them at a high risk of cardiovascular disease. Both food sources and the ingredients in traditional medications are essential to the treatment of this ailment. Seaweeds are naturally occurring dietary bioresources that have garnered a lot of attention recently. The local seaweed Kappaphycus striatus (K. striatus) contains numerous beneficial phytoconstituents that have the potential to serve as new drug Kappaphycus striatus, Seaweed, LCMS, GCMS, HPLC, Hypercholesterolemia https://www.ijper.org/evaluation-of-the-knowledge-opinion-and-approaches-of-pharmacists-physicians-die 2026-04-13T05:54:08.792855+00:00 Evaluation of the Knowledge, Opinion, and Approaches of Pharmacists, Physicians, Dieticians, and the Public on Herbal Products Used for Weight Control and Slimming in Northern Cyprus 2024-10-04 10.5530/ijper.58.4.111 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1318.pdf **Background::** This study explores the perspectives of Northern Cyprus (NC) pharmacists, physicians, dieticians, and the public regarding Herbal Products (HP) for Weight Control (WC) and slimming, contributing valuable insights to healthcare practices and public awareness. **Aims::** The objective is to comprehensively assess the knowledge, attitudes, and practices of community pharmacists, physicians/dieticians, and the general public in NC concerning WC and slimming. Additionally, the study Obesity, Weight, Herbal Products, Northern Cyprus, Pharmacist https://www.ijper.org/the-therapeutic-and-toxic-effects-of-artemisia-herba-alba-extract-on-the-reprodu 2026-04-13T05:54:08.792855+00:00 The Therapeutic and Toxic Effects of Artemisia herba alba Extract on the Reproductive System and Fertility of Male Rabbits Oryctolagus cuniculus 2024-10-04 10.5530/ijper.58.4.129 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1174.pdf **Background:** Medicinal plants are generally considered beneficial to health because they contain secondary metabolites responsible for their therapeutic effects. However, some plants used in phytotherapy are toxic due to their high content of toxic components. **Objectives:** The purpose of this study is to assess the therapeutic and toxic action of Artemisia herba alba (AHA) by using increasing doses of the plant extract, on reproductive parameters, plasma testosterone levels, organs� relat Artemisia herba Alba, Reproduction, Sperm Quality, Histology, Estrogen Receptor, Health https://www.ijper.org/development-and-characterization-of-liquisolid-compact-to-improve-dissolution-of 2026-04-13T05:54:08.792855+00:00 Development and Characterization of Liquisolid Compact to Improve Dissolution of an Antihypertensive Drug 2024-10-04 10.5530/ijper.58.4.132 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1198.pdf **Background::** The goal of the current research was to use the straight forward, scalable, and economical Liquisolid compact to improve the dissolution profile of the poorly soluble medication Ramipril. **Objectives::** Utilising various polymers and liquid vehicles, the study's objective was to develop and characterise Liquisolid compact. **Materials and Methods::** Ramipril liquisolid were formulated using Propylene glycol and PEG 400 as liquid vehicle, MCC as a carrier, Aerosil 200 as a c Ramipril, Liquisolid, Dissolution enhancement, Immediate drug release, FT-IR https://www.ijper.org/a-simultaneous-quantification-of-four-potential-genotoxic-impurities-purinediol 2026-04-13T05:54:08.792855+00:00 A Simultaneous Quantification of Four Potential Genotoxic Impurities Purinediol Hydrochloride, N7-Isomer, Monoalkyl Contaminant and Diacetyl Purine Present in Penciclovir Using LC-MS/MS 2024-10-04 10.5530/ijper.58.4.138 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1255.pdf **Background::** Penciclovir is a medication for antiviral therapy for curing different kinds of herpes virus infections. The four contaminants are the starting materials of Penciclovir which are present at a trace level in the drug in which one of its impurities is its isomer. Purinediol Hydrochloride, N7-Isomer, Monoalkyl contaminant and Diacetyl Purine are the four potential impurities present in the drug. **Materials and Methods::** The separation was achieved in the Zorbax SB C8 column usi Penciclovir, Genotoxic impurities, LC-MS/MS method, Multiple Reaction Monitoring (MRM), Method Development and Validation https://www.ijper.org/hr-lcms-metabolite-profiling-and-in-silico-evaluation-of-the-antidiabetic-activi 2026-04-13T05:54:08.792855+00:00 HR-LCMS Metabolite Profiling and in silico Evaluation of the Antidiabetic Activity of Methanolic Leaf Extract of Chrozophora rottleri (Geiseler) A. Juss. Ex Spreng. 2024-10-04 10.5530/ijper.58.4.140 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1277.pdf **Background::** Chrozophora rottleri (Geiseler) A. Juss. ex Spreng. is a well-known traditional medicinal plant with a complex biological profile, though inadequate research has been established on its possible anti-diabetic effects and active metabolite profiling. In the present work, Methanolic leaf extracts (MECR) was used to identify plant metabolites by HR-LCMS analysis, and in silico docking studies and screened to assess their hypoglycaemic potential. **Materials and Methods::** In the C. rottleri, Antidiabetic activity, Antioxidant activity, Docking, HR-LCMS, in silico study https://www.ijper.org/augmented-optical-retention-and-improved-antibacterial-activity-against-conjunct 2026-04-20T05:41:05.033937+00:00 Augmented Optical Retention and Improved Antibacterial Activity against Conjunctivitis of Moxifloxacin Hydrochloride Entrapped in Microsponges in situ Gel: Formulation Evaluation and in vivo Remedial Value in Rabbits 2024-10-04 10.5530/ijper.58.4.144 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1336.pdf **Objectives::** Moxifloxacin hydrochloride is an antibiotic related to flouroquinolones class. It possessed reasonable to exceptional efficacy against gram-negative ocular pathogens. The prime goal of this study was to formulate and estimate moxifloxacin hydrochloride entrapped microsponge in situ gel to treat conjunctivitis. **Materials and Methods::** Moxifloxacin hydrochloride loaded microsponges was manufactured using modified emulsion-solvent dispersion technique. Optimized microsponge gr Microsponges, Moxifloxacin hydrochloride, Occular, Conjunctiva, Emulsion https://www.ijper.org/coumarin-123-triazole-hybrids-as-promising-antibacterial-agents-in-silico-molecu 2026-04-13T05:54:08.792855+00:00 Coumarin-1,2,3-Triazole Hybrids as Promising Antibacterial Agents: In silico Molecular Docking, ADMET and Molecular Dynamics Simulation Studies (Exploring in silico Antibacterial Potential of Coumarin-1,2,3-triazoles) 2024-10-04 10.5530/ijper.58.4.137 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1242.pdf **Background::** A lot of coumarin-1,2,3-triazole hybrids have been reported to show antibacterial activities, but most of them are unexplored in clinical studies. Herein, we wish to apply in silico docking, physiochemical predictions and molecular dynamics simulation studies on coumarin-1,2,3-triazole hybrids to explore their successful transformation in to broad spectrum antibacterial agent for clinical use. **Materials and Methods::** A library of 196 compounds with the coumarin-1,2,3-triazo Coumarin-1,2,3-triazoles, antibacterial, docking Extract, Molecular Dynamics, ADMET, Drug resistance https://www.ijper.org/efficacy-and-safety-of-erythromycin-in-the-treatment-of-mycoplasma-pneumonia-in 2026-04-13T05:54:08.792855+00:00 Efficacy and Safety of Erythromycin in the Treatment of Mycoplasma Pneumonia in Children: A Systematic Review and Meta-Analysis 2024-10-04 10.5530/ijper.58.4.113 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1007.pdf **Aim:** The effectiveness and safety of erythromycin for treating mycoplasma pneumonia in pediatric patients is a subject of significant interest. This study aims to conduct a systematic review and meta-analysis to assess the efficacy and safety of erythromycin in the treatment of mycoplasma pneumonia in children,with the goal of providing evidence-based recommendations for pediatric care. **Methodology:** We systematically reviewed randomized controlled trials published prior to January 1, 20 Erythromycin, Mycoplasma pneumonia in children, Clinical efficacy, Safety, Meta-analysis, Systematic evaluation https://www.ijper.org/enhancement-of-solubility-and-dissolution-rate-of-poorly-soluble-anticancer-drug 2026-04-13T05:54:08.792855+00:00 Enhancement of Solubility and Dissolution Rate of Poorly Soluble Anticancer Drug Using Nanostructured Lipid Carrier Based Drug Delivery System 2024-10-04 10.5530/ijper.58.4.130 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1184.pdf **Background:** Prostate cancer is the leading cause of death in men over the age of 50, making it one of the most common cancers. Current treatments available such as chemotherapy, surgery are associated with many side-effects. Due to non-specificity and poor solubility of many anticancer drugs, less amount of drug is available at the absorption site. The current study aimed to develop Nanostructured Lipid Carriers (NLCs) of the poorly soluble anticancer drug Flutamide. **Materials and Methods Flutamide, Solubility, Nanostructured lipid carriers, Lipids https://www.ijper.org/leonurine-attenuates-streptozotocin-induced-diabetic-nephropathy-in-rats-by-miti 2026-04-13T05:54:08.792855+00:00 Leonurine Attenuates Streptozotocin-Induced Diabetic Nephropathy in Rats by Mitigating Dyslipidemia and Inflammation 2024-10-04 10.5530/ijper.58.4.125 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1139.pdf **Background:** Diabetic Nephropathy (DN) is one of the serious complications associated with a prolonged diabetic condition. DN continues to be the primary cause of morbidity and mortality among diabetic patients globally. **Objectives:** The objective of the current work is to study the nephroprotective properties of leonurine in the diabetic nephropathy model. **Materials and Methods:** The experimental rats were induced with DN through an administration of 65 mg/kg of Streptozotocin (STZ) Renal fibrosis, Hyperglycemia, Leonurine, Insulin, Dyslipidemia https://www.ijper.org/rutaecarpine-induces-apoptosis-via-a-mitochondrial-membrane-mediated-pathway-in 2026-04-13T05:54:08.792855+00:00 Rutaecarpine Induces Apoptosis via a Mitochondrial Membrane-Mediated Pathway in the Human Liver Cancer Cells (HepG2) 2024-10-04 10.5530/ijper.58.4.118 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1070.pdf **Background:** The desire for novel drugs and bioactive ingredients to combat serious illnesses like cancer has grown dramatically. A great deal of research is being done to discover and create new medications. **Aim:** According to research, cirrhosis brought on by the Hepatitis C and B Viruses (HCV) is thought to be responsible for almost half of occurrences of Hepatocellular Carcinoma (HCC). These viruses alter the DNA of the liver cells they infect, turning healthy liver cells into cancero Rutaecarpine, Hepatocellular carcinoma, Apoptosis, Markers https://www.ijper.org/evaluation-of-the-combinatory-anti-depressant-approach-of-metformin-and-querceti 2026-04-13T05:54:08.792855+00:00 Evaluation of the Combinatory Anti-Depressant Approach of Metformin and Quercetin in Mice Exposed to Chronic Unpredictable Mild Stress Behavorial Alteration 2024-10-04 10.5530/ijper.58.4.124 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1130.pdf **Background:** To develop a new drug approach, it is necessary to understand possible ways by which suppression of depressive symptoms can be achieved at the biochemical level. One such protein, which can help relieve depression when targeted, is AMP-Activated Protein Kinase (AMPK). The present in vivo study has focussed on AMPK and inflammatory cytokines as potential targets for improving Brain-Derived Neurotrophic Factor levels (BDNF) in depression. **Materials and Methods:** A parallel ther Brain Derived Neurotropic Factor, Corticosterone, Depression, Interlukin-1β, Interlukin-6, Tumour necrosis factor-α https://www.ijper.org/unveiling-ethical-ai-an-in-depth-bibliometric-and-visual-exploration 2026-04-13T05:54:08.792855+00:00 Unveiling Ethical AI: An In-Depth Bibliometric and Visual Exploration 2024-10-04 10.5530/ijper.58.4.120 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1084.pdf This study meticulously delineates the research progression, focal points, developmental path and emergent evolutionary trajectories of computational intelligence within the domain of ethics. A comprehensive quantitative report, embodying bibliometric principles, was prepared using the Web of Science Core Collection database. The methodology involved conducting an extensive search for original articles and reviews related to “ethical artificial intelligence” Relevant data from these sources were Bibliometric analysis, Artificial intelligence, Ethical issue, Citespace, VOSviewer https://www.ijper.org/strategic-targeting-of-plasmodium-dihydroorotate-dehydrogenase-through-antimicro 2026-04-13T05:54:08.792855+00:00 Strategic Targeting of Plasmodium Dihydroorotate Dehydrogenase through Antimicrobial Artemisinin Chiral Centers and their Derivatives: An Integrative Study Using Network Pharmacology and Isothermal Titration Calorimetry 2024-10-04 10.5530/ijper.58.4.146 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1356.pdf **Background::** Developing effective antimalarial medications requires understanding the interactions between Plasmodium Dihydroorotate dehydrogenase (DHOdehase) and Artemisinin, including its fourteen stereoisomers (R/S) which have distinct pharmacological effects due to seven chiral centres. **Materials and Methods::** Computational techniques, including molecular docking and network pharmacology, were used to generate and analyse Artemisinin’s stereoisomers. The binding strength and durabil Malarial Parasite, Plasmodium species, Artemisia annua, Artemisinin, Dihydroorotate dehydrogenase, Molecular docking, Network Biology https://www.ijper.org/biological-activity-of-ethanol-extract-of-terminalia-chebula-dried-carp-against 2026-04-20T05:01:25.019382+00:00 Biological Activity of Ethanol Extract of Terminalia chebula Dried Carp against Bacterial Wilt of Lycopersicum esculentum and its Mechanism of Inhibition 2024-10-04 10.5530/ijper.58.4.127 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1157.pdf **Background:** The extract of Terminalia chebula was explored with a new perspective to control tomato bacterial wilt, opening up a new way in agriculture to control plant disease in an organic way with less impact on the environment, ecosystem and consumers. **Materials and Methods:** The preliminary study reveals the presence of phenolic compounds, coumarins and anthroquinones in the ethanol extract and was analysed further by GCMS and NMR to identify the compounds, structure and functional Ralstonia solanacearum, Terminalia chebula, Antibacterial activity, Macro-dilution method, Pot culture, Organic control https://www.ijper.org/the-effect-of-sophoridine-on-nsclc-by-down-regulation-of-mtor-and-notch1 2026-04-13T05:54:08.792855+00:00 The Effect of Sophoridine on NSCLC by Down Regulation of mTOR and NOTCH1 2024-10-04 10.5530/ijper.58.4.147 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1373.pdf **Introduction:** Sophoridine, an alkaloid compound which is isolated from various plant species like Sophoraalopecuroides and Sophora flavescens. It identified to have potential pharmacological properties, including anti-inflammatory, anticancer and antiviral activities. The effect of the sophoridine on mTOR and NOTCH1 pathways that are critical in NSCLC is not well understood. **Materials and Methods:** In order to assess the virtual interaction of mTOR and NOTCH1 with sophoridine, we employe Sophoridine, Natural compound, NSCLC, mTOR, NOTCH1 https://www.ijper.org/plant-bioactive-compounds-crucial-pharmacological-properties-and-role-of-elicito 2026-04-13T05:54:08.792855+00:00 Plant Bioactive Compounds: Crucial Pharmacological Properties and Role of Elicitors in Enhancing Production 2024-10-04 10.5530/ijper.58.4.115 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1034.pdf Plant secondary metabolites play a vital role in developing numerous industrial products. Nutritive products developed from natural sources have better acceptance and demand than chemically synthesized products. Biologically active secondary metabolites play an important role in synthesizing various pharmaceutical drugs, and demand for its industrial manufacture is on the rise. In vitro cell suspension cultures using elicitors are a means of increasing the production of secondary metabolites in Culture, Secondary metabolites, Elicitors, Bioactive compounds, Pharmacological properties https://www.ijper.org/from-risk-to-resilience-uncovering-drug-recall-trends-and-bolstering-safety-stra 2026-04-13T05:54:08.792855+00:00 From Risk to Resilience: Uncovering Drug Recall Trends and Bolstering Safety Strategies 2024-10-04 10.5530/ijper.58.4.114 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1015.pdf The process of officially calling something back to its original or initial location is termed as “recall.” Pharmaceutical recalls involve requesting to get back a product after it leaves the manufacturer to reach the distributor, retailer, or consumer. In place of the discovery of defect that affects the quality safety and efficacy of the product. Drug product recalls occur due to various reasons such as wrong or unapproved drugs, undeclared ingredients, contamination, incorrect information, an Recalls, Sterility, Impurity, Public health, Observations https://www.ijper.org/unveiling-betulinic-acid-as-a-potent-cdk4-inhibitor-for-cancer-therapeutics 2026-04-13T05:54:08.792855+00:00 Unveiling Betulinic Acid as a Potent CDK4 Inhibitor for Cancer Therapeutics 2024-10-04 10.5530/ijper.58.4.123 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1117.pdf **Background:** CDK4 play a pivotal role in cell cycle regulation, making it a critical players in the development and progression of cancer. In recent years, there has been a growing interest in targeting CDK4 for cancer therapeutics, with a focus on the identification and development of small molecule inhibitors. **Materials and Methods:** This work, using a strong in silico and in vitro methodology, reveals Betulinic Acid’s inhibitory efficacy against CDK4 for cancer therapy. Betulinic Acid, Betulinic Acid, Cancer therapeutics, CDK4 inhibition, Lung cancer treatment, Molecular docking, Pharmacokinetic viability https://www.ijper.org/formulation-of-pregabalin-loaded-trimethyl-chitosan-microspheres-for-nasal-drug 2026-04-13T05:54:08.792855+00:00 Formulation of Pregabalin-Loaded Trimethyl Chitosan Microspheres for Nasal Drug Delivery: In vitro, ex vivo and in vivo Characterization 2024-10-04 10.5530/ijper.58.4.134 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1215.pdf **Background::** Polar drugs make it difficult to cross nasal cells. Trimethyl Chitosan (TMC) microspheres help absorption by opening junctions, increasing drug retention. Pregabalin absorbs well orally but delays crossing the brain, limiting emergency seizure treatment. The present study aimed to develop pregabalin-loaded TMC microspheres for intranasal administration in epilepsy. **Materials and Methods::** The microspheres were prepared by ionotropic gelation method using TMC and glutaraldeh Pregabalin, Trimethyl chitosan, Microspheres, Intranasal drug delivery, Epilepsy https://www.ijper.org/electrometric-study-on-nature-and-stability-of-coii-niii-and-cuii-complexes-with 2026-04-13T05:54:08.792855+00:00 Electrometric Study on Nature and Stability of CoII, NiII and CuII Complexes with 5-Sulfosalicylic Acid in DMSO-Water Mixtures 2024-10-04 10.5530/ijper.58.4.139 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1267.pdf **Background::** The bioavailability of an element and its toxicity based on its chemical species. According to IUPAC the concept of chemical speciation is defined as it is a form of an element according to its oxidation state, isotopic composition, or complex and molecular structure. The speciation studies are profoundly plays a major role in studying the nature of trace elements in a human organism. Speciation of an element has a noticeable impact on bioavailability, distribution and toxicity. Acid-base equilibria, 5-Sulfosalicylic acid, Dimethyl sulfoxide, Binary complexes and Dielectric constant https://www.ijper.org/shikimate-kinase-1-from-klebsiella-pneumoniae-as-a-new-drug-target-enzyme-insigh 2026-04-13T05:54:08.792855+00:00 Shikimate Kinase 1 from Klebsiella pneumoniae as a New Drug Target Enzyme: Insights from Comparative Modeling and Molecular Dynamics 2024-10-04 10.5530/ijper.58.4.122 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1110.pdf **Background:** Klebsiella pneumoniae, a Gram-negative bacterium, is an established nosocomial pathogen that is particularly dangerous to immunosuppressed individuals, causing diseases such as sepsis, pneumonia, urinary tract infections and respiratory tract infections. The emergence of multidrug resistant strains of this bacterium poses a significant challenge to current therapeutic strategies, highlighting the urgent need for new drug targets. **Materials and Methods:** Our study highlights t Klebsiella pneumoniae, Shikimate Kinase 1, Comparative modeling, AlphaFold2, Molecular dynamics simulations https://www.ijper.org/synthesis-anti-inflammatory-and-in-silico-studies-of-few-novel-124-triazole-deri 2026-04-13T05:54:08.792855+00:00 Synthesis, Anti-inflammatory and in silico Studies of few novel 1,2,4-Triazole Derived Schiff Base Compounds 2024-10-04 10.5530/ijper.58.4.136 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1235.pdf **Background::** Every year more than 1 billion prescriptions are written for all NSAIDs and yet the quest to develop new NSAIDs remains prominent. **Objectives::** The current investigation's goal was to synthesize and assess the anti-inflammatory potential of a few more recent 1,2,4-triazole derivatives. **Materials and Methods::** The synthesis of the 1,2,4-triazole compounds (SPG1-5) was accomplished in three distinct steps involving formation of hydrazide of ibuprofen and followed by cycl Triazole, Antiprotease, Anti-inflammatory, Albumin, in silico, in vitro https://www.ijper.org/antibacterial-effects-of-bioactive-boswellic-acids-loaded-chitosan-nanoparticles 2026-04-13T05:54:08.792855+00:00 Antibacterial Effects of Bioactive Boswellic Acids Loaded Chitosan Nanoparticles against Gram-Positive and Gram-Negative Bacteria 2024-10-04 10.5530/ijper.58.4.131 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1189.pdf **Background::** Boswellic acids are naturally occurring pentacyclic terpenoids that have revealed valuable anti-inflammatory, antiproliferation and anticancerous activities. Instead of these effects boswellic acids also possess antibacterial potential reported in the literature. However, these phytoconstituents associated with low aqueous solubility and bioavailability restrictions. The present study aimed to explore the antibacterial effects of boswellic acids by means of nano formulations. * Boswellic acids, Chitosan nanoparticles, Antibacterial activity https://www.ijper.org/phytochemical-study-polyphenols-determination-and-evaluation-of-antioxidant-acti 2026-04-13T05:54:08.792855+00:00 Phytochemical Study, Polyphenols Determination and Evaluation of Antioxidant Activity of Satureja calamintha from Morocco 2024-10-04 10.5530/ijper.58.4.128 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1167.pdf **Introduction:** The domestication of Satureja calamintha, either because of its superior tolerance to disease and environmental factors or because of its potential for larger quantities of useful chemicals. **Materials and Methods:** wild plants were harvested in the Ksar El Kabîr region, Morocco, and seeds were planted in open-air plots. Part of the cultivated plant was then harvested after one year of planting, while the other was harvested after two years. **Results:** The results show th Satureja calamintha (L), Wild plant, Cultivated plant, Flavonoids, Polyphenols, Antioxidant potential https://www.ijper.org/preclinical-studies-of-euphorbia-lactea-aerial-extract-on-atherogenic-diet-induc 2026-04-13T05:54:08.792855+00:00 Preclinical Studies of Euphorbia lactea Aerial Extract on Atherogenic-Diet-Induced Atherosclerosis 2024-10-04 10.5530/ijper.58.4.126 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1149.pdf **Background:** Atherosclerosis is a complex progressive pathological process that produces lesions in the inner wall of an artery because of the abnormal lipid metabolism, and dysregulation of inflammatory processes. Increased levels of Low-Density Lipoprotein (LDL) and Total Cholesterol (TC) lead to hyperlipidaemia which is a major risk factor for atherosclerosis. **Materials and Methods:** This research comprises the assessment of hydro-alcoholic extract of the aerial part of Euphorbia lacte Atherosclerosis, High-fat diet, Hypolipidemic, E. lactea, Heart attack, Stroke https://www.ijper.org/research-progress-in-mechanisms-of-drug-resistance-of-macrolide-antibiotics-resi 2026-04-13T05:54:08.792855+00:00 Research Progress in Mechanisms of Drug-Resistance of Macrolide Antibiotics Resistance in Mycoplasma pneumoniae 2024-10-04 10.5530/ijper.58.4.117 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-4-1054.pdf **Aim/Background:** This review aims to enhance understanding of Mycoplasma pneumoniae (MP) infection and Macrolide-Resistant Mycoplasma pneumoniae (MRMP) pneumonia, emphasizing their epidemiological characteristics and resistance mechanisms. MP is a major cause of Community-Acquired Pneumonia (CAP) in children, with potential extra-pulmonary manifestations. The objective is to guide early diagnosis and timely treatment, addressing the challenges posed by MP’s resistance to β-Lactam and vancomyc Mycoplasma pneumoniae, Pneumonia, Macrolide Antibiotics, Drug Resistance, Mechanism https://www.ijper.org/synthesis-therapeutic-potential-quantum-studies-and-molecular-properties-of-amin 2026-04-13T05:54:09.781339+00:00 Synthesis, Therapeutic Potential, Quantum Studies and Molecular Properties of Amino Acid Fused 1,3,4-Oxadiazole Derivatives as an Unnatural Amino Acids 2024-08-08 10.5530/ijper.58.3s.107 **Background:** In present study 1,3,4-oxadiazole derivatives with iso-sterically fused amino acids was attempted to synthesize. As variety of chemical reactions that 1, 3 and 4-oxadiazole molecules can experience, it made them very useful for searching of molecule altogether its high advantaged structure having enormous biological potential. Heterocyclic ring fusion has yielded compounds with a diverse array of biological functions. In the biological system, amino acids are important. With the Unnatural amino acids, Oxadiazole, Microwave synthesis, Scavenging activity, Amino acids, Quantum Studies, Molecular Properties https://www.ijper.org/reserpine-induces-apoptosis-in-drug-resistant-cancer-through-modulating-stat3-an 2026-04-13T05:54:09.781339+00:00 Reserpine Induces Apoptosis in Drug-Resistant Cancer through Modulating STAT3 and NF-κB Signaling 2024-08-08 10.5530/ijper.58.3s.91 **Introduction:** A major feature of drug-resistant cancer is the overexpression of transcription factors. During the study, reserpine, an indole alkaloid, was examined for its anticancer effects on cancer with drug resistance. **Objectives:** The objective of this study was to explore the anti-apoptotic impacts of reserpine in drug-resistant cancer cells by impeding the nuclear translocation of NF-κB and STAT3. **Materials and Methods:** For the in vitro study of reserpine’s anticancer activi Reserpine, STAT3, NF-κB, ROS, Apoptosis https://www.ijper.org/characterizations-of-the-secondary-metabolites-of-the-sea-squirt-diplosoma-liste 2026-04-13T05:54:09.781339+00:00 Characterizations of the Secondary Metabolites of the Sea Squirt Diplosoma listerianum Milne-Edwards, 1841) (Ascidiacea, Enterogona) and its Associated Micro-organisms 2024-08-08 10.5530/ijper.58.3s.90 **Background:** The biochemistry of secondary metabolites of marine origin has been identified as a promising area for obtaining new and potent pharmaceutical agents. These secondary metabolism molecules may have important functions such as anti-biotic and anti-parasitic activity, mediate symbiotic relationships between organisms and even have reproductive functions, representing a great ecological advantage for the survival of marine organisms. **Aim:** This study aimed to characterize the sec Diplosoma listerianum, Bacteriostatic action, Mouse fibroblasts, Field study, Aromatic compounds https://www.ijper.org/green-synthesis-of-silver-nano-particles-structural-characterization-and-their-a 2026-04-13T05:54:09.781339+00:00 Green Synthesis of Silver Nano Particles Structural Characterization and their Antioxidant and Anticancer Potential Using Adenocarcinoma (A549) Cell Line 2024-08-08 10.5530/ijper.58.3s.99 **Background:** Over the past two decades, Silver Nanoparticles (AgNPs) have demonstrated a wide range of antioxidant and anticancer properties. Vinca alkaloid exhibits the anticancer efficacy by direct metaphase arrest of cell division. **Aim:** The present study is to develop a green synthesis method for producing silver nanoparticles using vinca, the antioxidant and anticancer potential was assessed using A549 cells. **Materials and Methods:** The synthesized AgNPs were analyzed using Fouri Silver Nanoparticle, Vinca, Anticancer, Catharanthus roseus, Antiproliferative https://www.ijper.org/optimization-and-characterization-of-lamivudine-loaded-tcs-pegmmt-polymeric-nano 2026-04-13T05:54:09.781339+00:00 Optimization and Characterization of Lamivudine-Loaded TCS-PEG/MMT Polymeric Nanocomposites for Enhanced Antiretroviral Therapy 2024-08-08 10.5530/ijper.58.3s.92 **Background:** Acquired Immunodeficiency Syndrome (AIDS), caused by the Human Immunodeficiency Virus (HIV) was initially associated with rapid disease progression and high mortality rates. However, advances in drug delivery systems have aimed to optimize therapeutic outcomes, especially for medications facing challenges such as toxicity, uneven distribution, instability and formulation complexities. **Materials and Methods:** In this study, we introduce TCS-PEG/MMT composites, a novel formulat Nanocomplex, Lamivudine, Montmorillonite, Human immunodeficiency virus, Optimization https://www.ijper.org/simultaneous-quantification-of-famotidine-and-paba-by-first-order-derivative-spe 2026-04-13T05:54:09.781339+00:00 Simultaneous Quantification of Famotidine and PABA by First Order Derivative Spectral Technique of UV Spectrophotometric from FMT-PABA Cocrystals 2024-08-08 10.5530/ijper.58.3s.103 **Objectives:** The investigation article intends is to build and validate a more convenient scientific approach to accurately simultaneously determine famotidine and para-amino benzoic acid from their cocrystals **Significance:** The zero-order spectra of both drugs demonstrated significant overlap between the two spectra curves; therefore, the simultaneous estimation of two drugs by zero-order spectra method was not feasible. Therefore, to overcome this and facilitate simultaneous analysis of Zero-crossing, First-order derivative spectra, Simultaneous estimation https://www.ijper.org/development-and-evaluation-of-gastroretentive-bioadhesive-tablet-of-atenolol-usi 2026-04-13T05:54:09.781339+00:00 Development and Evaluation of Gastroretentive Bioadhesive Tablet of Atenolol Using a Naturally Occurring Biodegradable Polymer 2024-08-08 10.5530/ijper.58.3s.86 **Aim:** Using atenolol as a model active pharmaceutical and galactomannan from the seeds of Trigonella foenumgraecum as a mucoadhesive polymer, an effort was made to develop a gastroretentive bioadhesive floating delivery system to improve the residence time in the stomach. **Materials and Methods:** Different formulations were made with Hydroxypropyl Methyl Cellulose (HPMC) and galactomannan. Galactomannan was chosen because of its exceptional swelling properties in aqueous environments. In t Atenolol, Galactomannan, Gastroretentive floating bioadhesive tablets, HPMC, Natural polymer https://www.ijper.org/formulation-and-evaluation-of-fast-dissolving-tablets-of-oxcarbazepine-using-liq 2026-04-13T05:54:09.781339+00:00 Formulation and Evaluation of Fast Dissolving Tablets of Oxcarbazepine Using Liquisolid Technology 2024-08-08 10.5530/ijper.58.3s.89 **Background/Aim:** The aim of the study was to improve the dissolution profiles of Oxcarbazepine (OXC) from its tablets. This study was done to evaluate the effects of different formulation variables, i.e. type of non-volatile liquid vehicles on oxcarbazepine dissolution rate from its tablets. **Materials and Methods:** The liquisolid tablets were formulated with three different liquid vehicles, namely Polyethylene glycol 200, Propylene glycol and 20% Tween 80 aqueous solution. Micro-crystalli Oxcarbazepine, Fast dissolving tablets, Liquisolid technique, Solubility, Dissolution rate https://www.ijper.org/exploring-the-phytoconstituents-differential-pharmacology-and-interaction-with-e 2026-04-13T05:54:09.781339+00:00 Exploring the Phytoconstituents, Differential Pharmacology, and Interaction with Empagliflozin of Olea europaea Leaves Extracts 2024-08-08 10.5530/ijper.58.3s.100 **Background:** The Olea europaea L. leaves have long been used in treating various illnesses. Its pharmacological activity based on the phytoactive constituents; therefore, optimizing the extraction process should intensify the benefits. **Aim:** The study aimed to optimize the extraction process for O. europaea L. leaves, evaluate their antioxidant and anti-inflammatory activities, and explore their influence on the biochemical parameters of diabetic animals. **Materials and Methods:** The d Olive, Olea europaea L., Diabetes, Phytoanalysis, IL-6, IL1 beta, Phytotherapy, Biodiversity, Sustainability https://www.ijper.org/a-phytochemicals-approach-towards-the-role-of-dioxins-in-disease-progression-tar 2026-04-13T05:54:09.781339+00:00 A Phytochemicals Approach towards the Role of Dioxins in Disease Progression Targeting Various Pathways: Insights 2024-08-08 10.5530/ijper.58.3s.76 **Introduction:** Dioxins represent a category of enduring environmental contaminants that possess the capability to elicit endocrine disruptions and a spectrum of ailments, most notably encompassing malignancies, immunological impairments, and nervous system impairments. These chemical compounds incite the generation of Reactive Oxygen Species (ROS), consequently instigating cellular toxicity through the activation of the Aryl Hydrocarbon Receptor (AHR). Given the significant noxiousness associ Phytochemicals, Reactive oxygen species, Chronic disorders, Persistent organic pollutants, Aryl hydrocarbon receptor https://www.ijper.org/design-synthesis-molecular-docking-in-silico-adme-assessment-of-pyrrole-based-he 2026-04-13T05:54:09.781339+00:00 Design, Synthesis, Molecular Docking, in silico ADME Assessment of Pyrrole-Based Heterocyclic Amino Acid Derivatives as Potential Anticonvulsant Agent 2024-08-08 10.5530/ijper.58.3s.106 **Background:** Epilepsy is a neurological disorder characterized by anomalous brain activity, convulsionsandoddbehaviour.Tenpyrrolecarbohydratebasedanalogues(Va-Vj)weresynthesized with amide as intermediate in the current research with the goal of reducing convulsions and seizures. **Materials and Methods:** The newly developed compounds were synthesized. Numerous methods (IR, NMR, mass, elemental analysis, etc.,) were used to characterize these substances. Several models were used to test eac N-glycosides, Carbohydrate, Anticonvulsant activity, Pyrrole, ADME https://www.ijper.org/formulation-of-sustained-release-tablets-of-tolperisone-hcl-using-different-blen 2026-04-13T05:54:09.781339+00:00 Formulation of Sustained-Release Tablets of Tolperisone HCl Using Different Blends of Hydrophilic and Hydrophobic Polymers 2024-08-08 10.5530/ijper.58.3s.88 **Background:** Tolperisone Hydrochloride (HCl) is a muscle relaxant that relaxes muscles by acting on the Central Nervous System (CNS). It acts at the spinal cord level by blocking calcium and sodium channels. It primarily inhibits transmitter release from primary afferent terminals through pre-synaptic inhibition via simultaneous action on voltage-gated sodium and calcium channels. Its elimination half-life t is 1.5 to 2.5 hr. To maintain a constant plasma concentration, conventional Tolperiso Tolperisone HCl, Muscle Relaxant, Sustained Release, HPMC K100, Ethyl Cellulose https://www.ijper.org/method-development-and-validation-of-antihypertensive-drugs-using-hplc-technique 2026-04-13T05:54:09.781339+00:00 Method Development and Validation of Antihypertensive Drugs Using HPLC Technique 2024-08-08 10.5530/ijper.58.3s.105 **Aim:** A validated RP-HPLC method was established for the quantification of Amlodipine and Metoprolol succinate according to ICH guidelines. **Materials and Methods:** This method utilized a Phenomenex (US) C18 column with dimensions of 250X4.6 mm I.D and a particle size of 5 µm. Employing an isocratic elution technique, the mobile phase comprised pH 3.0 phosphate buffer solution and acetonitrile. Detection occurred at a wavelength of 215 nm and a flow rate of 1 mL/min was chosen to ensure op Amlodipine, Metoprolol succinate, Retention time, Correlation coefficient, RP-HPLC https://www.ijper.org/study-of-the-effect-of-magnetic-serum-albumin-nanoparticles-on-cultured-mice-ren 2026-04-13T05:54:09.781339+00:00 Study of the Effect of Magnetic Serum Albumin Nanoparticles on Cultured Mice Renal Mesangial Cells and Submandibular Cells Using Different Biological Assays 2024-08-08 10.5530/ijper.58.3s.83 **Background:** Bovine Albumin Nanoparticles (BAN) have a high magnetic susceptibility and great potential for biomedical applications. **Aim:** Evaluate the in vitro effects of magnetic BAN on mouse renal and submandibular cells. **Materials and Methods:** The ferromagnetic iron oxide Nanoparticles (NPs) were lyophilized and diluted in Dulbecco’s modified eagle culture medium. The diameters of the NPs were measured. Mouse renal and submandibular cells were cultured from an initial passage of Bovine albumin nanoparticles, Mouse renal and submandibular cells, Genotoxicity, Cytotoxicity, Degenerative cells https://www.ijper.org/development-of-colon-targeted-extended-drug-delivery-system-for-mebendazole-usin 2026-04-13T05:54:09.781339+00:00 Development of Colon Targeted Extended Drug Delivery System for Mebendazole Using Grafted Natural Polymers 2024-08-08 10.5530/ijper.58.3s.85 **Background:** Even though the natural polymers are biodegradable, non-toxic and cost effective, but these suffer with some of drawbacks like uncontrolled drug release, enzymatic degradation, reduction in viscosity on long term storage, thermal instability etc. The aforesaid limitations can be overcome by grafting of natural polymers to obtain high performance biomaterials for drug delivery system. **Materials and Methods:** Purified fenugreek and mesquite gums were grafted with acrylamide usi Grafting, Fenugreek gum polymer, Mesquite gum polymer, Helminthiasis, Drosophila melanogaster, Elemental analysis https://www.ijper.org/biosynthesis-of-silver-nanoparticles-from-canavalia-rosea-and-its-antiproliferat 2026-04-13T05:54:09.781339+00:00 Biosynthesis of Silver Nanoparticles from Canavalia rosea and its Antiproliferative Effect on MCF-7 Cancer Cell Line 2024-08-08 10.5530/ijper.58.3s.95 **Aim:** The generation of silver nanoparticles via a green synthesis approach with leaf and stem extracts of Canavalia rosea is our prime objective. **Materials and Methods:** The fabricated Nanoparticles (AgNPs) are interpreted by Gas Chromatography-Mass Spectrometry (GC-MS), X-ray Diffraction method (XRD), Field Emission Scanning Electron Microscope (FESEM), Energy Dispersive X-ray Analysis (EDAX), UV spectroscopy and photoluminescence. GC-MS analysis revealed a single hit compound and eight Silver nanoparticles, GC-MS, Autodock Vina, FESEM, MCF-7, Canavalia rosea https://www.ijper.org/the-revolutionary-role-of-artificial-intelligence-ai-in-pharmaceutical-sciences 2026-05-01T06:48:39.325349+00:00 The Revolutionary Role of Artificial Intelligence (AI) in Pharmaceutical Sciences 2024-08-08 10.5530/ijper.58.3s.78 The traditional drug discovery process is expensive, time-consuming, and often leads to a high failure rate. The development of numerous new medications in the pharmaceutical sciences is only one example of how the advancement of artificial intelligence has opened up exciting new opportunities for developing intelligent modelling. Machine learning and deep learning are two examples of artificial intelligence that can sift through large datasets in search of promising new drugs. AI algorithms can Machine learning, Artificial intelligence, Drug discovery, Target identification, Artificial Neural Network (ANN) https://www.ijper.org/selecting-an-appropriate-animal-model-for-dyslipidemia 2026-04-13T05:54:09.781339+00:00 Selecting an Appropriate Animal Model for Dyslipidemia 2024-08-08 10.5530/ijper.58.3s.72 In recent years, dyslipidemia, a major risk factor for cardiovascular diseases is on the rise globally due to sedentary lifestyles and unhealthy diets. Though abundant data pertaining to the factors influencing dyslipidemia, the mechanism of action of various drugs and the pathogenesis of the disease are available in the literature, the disease is poorly understood. Animal models play a crucial role in investigating the pathophysiology and aid in developing effective formulations. Despite extens Dyslipidemia, Animal models, Cardiovascular diseases, Animal research, High-fat diet, in vivo model https://www.ijper.org/a-rapid-uplc-technique-for-quantification-of-tegafur-oteracil-and-gimeracil-in-b 2026-04-13T05:54:09.781339+00:00 A Rapid UPLC Technique for Quantification of Tegafur, Oteracil and Gimeracil in Bulk and Pharmaceuticals and its Validation 2024-08-08 10.5530/ijper.58.3s.104 **Background:** Tegafur (TEG) is a prodrug of 5-Fluorouracil (FU) that is mainly employed in the treatment of colorectal tumors combined with Gimeracil (GIM) and Oteracil (OTE) enhances its stability by enhancing the antineoplastic activity and reducing gastric irritation. **Aim:** The key focus of this research was to design a rapid Ultra Performance Liquid Chromatography (UPLC) and validate that it is uncomplicated, exact, responsive and reliable for quantifying the concentrations of tegafur, Tegafur, Gimeracil, UPLC, Oteracil, Stability https://www.ijper.org/synthesis-and-pharmacological-activities-of-benzothiazole-derivatives 2026-04-13T05:54:09.781339+00:00 Synthesis and Pharmacological Activities of Benzothiazole Derivatives 2024-08-08 10.5530/ijper.58.3s.74 The Research and Development in benzothiazole-based medicinal ingredients have turn into a hastily on the rise and gradually more lively topic. Broad number of compounds having Benzothiazole (BTZ) moiety are involved in the treatment of a various number of diseases with maximum curative potency. This review is aimed to afford modern progress in the synthesis of Benzothiazole analogues associated to the green chemistry. Literature surveys on scientific national and international journals, books a Benzothiazole, Heterocyclics, Synthesis, Structure Activity Relationship, Antibacterial https://www.ijper.org/interstitial-lung-diseases-classification-in-the-context-of-pharmaceutical-educa 2026-04-13T05:54:09.781339+00:00 Interstitial Lung Diseases Classification in the Context of Pharmaceutical Education and Research: A Two-Level Deep Learning Approach 2024-08-08 10.5530/ijper.58.3s.80 **Aim/Background:** In this work, a novel method for improving the quality of healthcare in the diagnosis of Interstitial Lung Disease (ILD) using High-Resolution Computed Tomography (HRCT) images is proposed. **Materials and Methods:** In contrast to previous research that necessitated the human identification of Regions of Interest (ROI), a two-phase deep learning method is presented. First, multi-scale feature extraction is used to precisely segment the lung in HRCT images using a conditiona Deep learning, Interstitial lung disease, Support vector machine, Lung segmentation, Lung Classification https://www.ijper.org/design-of-lamivudine-loaded-metal-organic-frameworks-mil-100-fe-by-microwave-ass 2026-04-13T05:54:09.781339+00:00 Design of Lamivudine Loaded Metal Organic Frameworks MIL 100 (Fe) by Microwave Assisted Chemistry 2024-08-08 10.5530/ijper.58.3s.108 **Background:** Lamivudine is an Anti-Viral Drug belongs to BCS Class II Drug which exhibits limited solubility and high permeability through oral route. **Aim:** The study was designed to predict the solubility potential of Lamivudine loaded Metal Organic Framework complexed with MIL 100 by using microwave assisted chemistry through topical route. **Materials and Methods:** In combination of MIL 100 (Fe) we utilize Ferric chloride hexahydrate as metal particle and benzene 1,3,5-carboxyl corro Metal Organic Frameworks, Ferric chloride hexahydrate, Benzene 1,3,5-tricarboxylic acid, Microwave assisted chemistry https://www.ijper.org/low-dose-lipopolysaccharide-induced-depressive-like-phenotype-is-mediated-by-pro 2026-04-13T05:54:09.781339+00:00 Low Dose Lipopolysaccharide-Induced Depressive-Like Phenotype is Mediated by Proinflammatory Cytokines in Mice and Role of Ketamine 2024-08-08 10.5530/ijper.58.3s.79 **Background:** Depression is a common mental illness, with an estimated 3.8% of global population affected. In the pathophysiology of depression, ketamine acts quickly in patients. Treatment with low-dose ketamine upon administration to stressed C57BL/6J mice is now a major translational research area to facilitate further innovation. **Objectives:** The present work was aimed to establish a depressant like animal model after 6 days of LPS injection, where LPS did not promote body weight loss. B/P, Cytokines, Depression, LPS, FST, SPT https://www.ijper.org/a-field-exploration-and-inventory-of-the-most-toxic-plants-of-southern-flora-tun 2026-04-13T05:54:09.781339+00:00 A field Exploration and Inventory of the Most Toxic Plants of Southern Flora Tunisian 2024-08-08 10.5530/ijper.58.3s.75 In the present work, a bibliographical survey of the toxicity of some plants of the southern Tunisia’s flora was conducted on several methanoic extracts from miscellaneous toxic plants of the southern Tunisian flora and chosen from among the most used plants in traditional medicine. In Tunisia, a host of extracts from about twenty plants have shown spasmolytic properties, while several extracts from some plants showed a high toxicity and 3 extracts from 2 plants proved curative properties. In th Tunisian flora, Plants, Toxic, Phytotherapy, Alkaloids, Antidote https://www.ijper.org/smart-manipulated-uv-spectroscopic-methods-for-resolving-the-overlapped-spectra 2026-04-13T05:54:09.781339+00:00 Smart Manipulated UV Spectroscopic Methods for Resolving the Overlapped Spectra for Quality Control of Two Analgesic Binary Combination Formulations 2024-08-08 10.5530/ijper.58.3s.82 **Background:** The combination of two drugs celecoxib + tramadol and diclofenac sodium + tramadol with different mechanisms of action is better for achieving effective pain control. **Materials and Methods:** The simple reproducible mathematically modified UV spectroscopic methods were established for concomitant evaluation of the binary combination of celecoxib + tramadol and diclofenac sodium + tramadol formulations. The first technique is predicated on separating the pure zero-order spectra Celecoxib, Tramadol, Diclofenac sodium, Derivative spectroscopy, Validation, Formulation https://www.ijper.org/ethanolic-extract-of-equisetum-arvense-a-potential-agent-against-rheumatoid-arth 2026-04-13T05:54:09.781339+00:00 Ethanolic Extract of Equisetum arvense: A Potential Agent against Rheumatoid Arthritis in Wistar Rats with Freund’s Complete Adjuvant-Induced Arthritis 2024-08-08 10.5530/ijper.58.3s.98 **Background:** Rheumatoid arthritis, a global autoimmune affliction affecting 0.3-1% of the population, is characterized by chronic inflammation and systemic symptoms. Dissatisfaction with conventional treatments leads individuals with chronic pain in rheumatoid arthritis to explore alternative medicine. Herbal remedies, including Equisetum arvense extract, are studied for their anti-inflammatory potential. **Aim:** This research focuses on evaluating the impact of E. arvense extract on experi Equisetum arvense, Complete Freund’s adjuvant, Hemoglobin, Inflammation, Joints https://www.ijper.org/qbd-powered-design-and-optimization-of-nanostructured-lipid-carriers-loaded-with 2026-04-13T05:54:09.781339+00:00 QBD-Powered Design and Optimization of Nanostructured Lipid Carriers Loaded with BCS class IV Anticancer Drug 2024-08-08 10.5530/ijper.58.3s.84 **Background:** The therapeutic efficacy of an active Pharmaceutical ingredient depends on its solubility in body fluids. The low bioavailability of nearly 90% of new active Pharmaceutical ingredients and 40% of the existing molecules is attributed to their poor solubility. The current study aimed to improve the oral bioavailability of lapatinib by designing and optimizing nanostructured lipid carriers for it. **Materials and Methods:** The formulation utilized the microemulsion technique as a QbD, Box Behnken design, Lapatinib, Nanostructured lipid carriers, Dissolution improvement, Microemulsion technique https://www.ijper.org/method-development-and-validation-for-the-quantification-of-abametapir-in-biolog 2026-04-13T05:54:09.781339+00:00 Method Development and Validation for the Quantification of Abametapir in Biological Matrices by LC-ESI-MS/MS 2024-08-08 10.5530/ijper.58.3s.102 **Aim:** A precise, linear and specific liquid chromatography-tandem mass spectrometry procedure was executed and subjected for validation for the quantification of plasma. **Materials and Methods:** The chromatography elution was carried out using a C18-Discovery column of 15 cm in length and 2.1 mm in internal diameter, packed with stationary phase particles of 5 µm size, at a flow rate of 0.80 mL/min. An isocratic elution process was conducted with a mobile phase solution consisting of metha LC-MS/MS, Abametapir, Metalloproteinase Inhibitor, Validation, Accuracy, Linearity https://www.ijper.org/assessment-of-anti-alzheimer-characterization-of-green-synthesized-zinc-nanopart 2026-04-13T05:54:09.781339+00:00 Assessment of Anti-Alzheimer Characterization of Green Synthesized Zinc Nanoparticles Containing Extract of Cordyceps militaris 2024-08-08 10.5530/ijper.58.3s.93 **Background:** In current research, Zinc Nanoparticles (ZnNPs) were synthesized using green synthesis technology. It is the best method which is eco-friendly and cost-effective. The extract of fungus Cordyceps militaris was used for this purpose, which was followed by muffle furnace assisted synthesis of zinc nanoparticles. **Objectives:** The main objective of this research work was to assess the anticholinesterase and antioxidant activity mediated Anti-Alzheimer activity of Cordyceps militar Zinc nanoparticles, Cordyceps militaris, Anti-cholinesterase, Alzheimer anti-Alzheimer, Green synthesis https://www.ijper.org/a-review-on-the-in-vitro-anticancer-potentials-of-acetogenins-from-annona-murica 2026-04-13T05:54:09.781339+00:00 A Review on the in vitro Anticancer Potentials of Acetogenins from Annona muricata Linn. a Potential Inducer of Bax-Bak and Caspase-3 Related Pathways 2024-08-08 10.5530/ijper.58.3s.73 Annona muricata Linn. (A. muricata) is a tropical evergreen fruit tree belonging to Annonaceae family, also referred as graviola, soursop or corossol. The chemical compounds isolated from this plant have linked to the ethnomedicinal properties and its anticancer properties. This review focus to highlight in vitro anticancer potentials of acetogenins isolated from A. muricata, which are potent inducer of Bax-Bak and Caspase-3 related pathways. More than 200 chemical substances that have been isol Annona muricata, Acetogenins, Apoptosis, Cancer cell lines https://www.ijper.org/scrutinizing-potential-phytoconstituents-from-bauhinia-variegata-in-mitigating-t 2026-04-13T05:54:09.781339+00:00 Scrutinizing Potential Phytoconstituents from Bauhinia variegata in Mitigating the Symptoms of Polycystic Ovarian Syndrome: A Computational Approach 2024-08-08 10.5530/ijper.58.3s.97 **Background:** Polycystic ovarian syndrome is a metabolic disorder majorly caused by the hormonal fluctuations in female and the current scenario explains that adolescents remain predominantly affected with this disorder. Bauhinia variegata assist in the treatment of various ailments and are used as an ingredient in targeting uterine disorders, yet the exact constituent that contributes on activity remains unknown. **Aim:** The main aim of our study is to determine the potent phytoconstituent Bauhinia variegata, Molecular docking, Molecular dynamics, Pharmacokinetic analysis, Toxicity prediction https://www.ijper.org/computational-study-and-evaluation-of-lidocaine-and-nitroglycerin-ointment-for-e 2026-04-13T05:54:09.781339+00:00 Computational Study and Evaluation of Lidocaine and Nitroglycerin Ointment for External Hemorrhoid Treatment 2024-08-08 10.5530/ijper.58.3s.81 **Background and Objectives:** Hemorrhoids are defined as swollen veins in the anus and lower rectum. Hemorrhoids are a common medical problem and have a negative impact on people’s lives. The drugs that are available on the market are limited, and therefore, the objective of the present research is to develop and evaluate a lidocaine and nitroglycerin ointment combination for enhanced external hemorrhoid treatment. **Materials and Methods:** Five formulations of 0.1% lidocaine and 0.1% nitrogl Hemorrhoids, Nitroglycerin, Lidocaine, Formulation, In silico, Physicochemical https://www.ijper.org/design-and-development-of-rebamipide-solid-dispersion-loaded-floating-beads-for 2026-04-13T05:54:09.781339+00:00 Design and Development of Rebamipide Solid Dispersion-Loaded Floating Beads for Ameliorated Therapeutics 2024-08-08 10.5530/ijper.58.3s.87 **Objectives:** Rebamipide, a gastroprotective drug, is used for preventing and treating ulcers but it has low aqueous solubility leading to poor bioavailability (10%). It acts both locally and systemically to provide gastroprotection and ulcer healing effects. The therapeutics of Rebamipide can be improved by enhancing its aqueous solubility and by sustaining its release in the stomach. **Materials and Methods:** The above objective was fulfilled by preparing solid dispersion of Rebamipide by Peptic Ulcer, Rebamipide, Poloxamer 407, Solid Dispersion, Floating Beads https://www.ijper.org/prospective-observational-study-of-adverse-drug-reactions-of-anti-her2-and-micro 2026-04-13T05:54:09.781339+00:00 Prospective Observational Study of Adverse Drug Reactions of Anti-HER2 and Microtubule Damaging Drugs Used in Cancer Treatment in a Tertiary Care Hospital 2024-08-08 10.5530/ijper.58.3s.109 **Background:** Cancer treatment has witnessed remarkable advancements with the development of targeted therapies, such as anti-HER2 agents and microtubule-damaging drugs. Despite their efficacy, these drugs can be associated with a spectrum of Adverse Drug Reactions (ADRs) that may impact patient safety and treatment outcomes. Data on the safety profile of cancer treatment are scarce. **Aim:** This prospective observational study aimed to systematically assess and characterize adverse drug rea Adverse drug reactions, Quality, Safety profile on cancer treatment, Patient care https://www.ijper.org/quality-control-of-hydrochlorothiazide-pharmaceuticals 2026-04-13T05:54:09.781339+00:00 Quality Control of Hydrochlorothiazide Pharmaceuticals 2024-08-08 10.5530/ijper.58.3s.101 **Background:** One of the organisational strategies to ensure the use of relevant good practises for each stage in the life cycle of pharmaceutical products is the market surveillance program, which aims to demonstrate product specification adherence. It uses analytical pharmacopoeial and literature-based approaches primarily to carry out quality control on the chosen pharmaceutical items. **Aim:** Development of a program for analytical control of different medicinal products containing 25 mg Market Surveillance Program, HPLC, Hydrochlorothiazide, System suitability test https://www.ijper.org/optimization-of-anti-inflammatory-activity-of-rauvolfia-tetraphylla-l-crude-extr 2026-04-13T05:54:09.781339+00:00 Optimization of Anti-Inflammatory Activity of Rauvolfia tetraphylla L. Crude Extracts Using Response Surface Methodology 2024-08-08 10.5530/ijper.58.3s.94 **Background:** The background of this study revolves around Rauvolfia tetraphylla and its potential anti-inflammatory properties. To explore the anti-inflammatory activity of crude extracts obtained from the leaf and fruit of R. tetraphylla, with the goal of identifying natural compounds that could serve as safer and more effective alternatives to conventional non-steroidal anti-inflammatory drugs. **Objectives:** Aim of the study is to identify the most potent anti-inflammatory activity from Rauvolfia tetraphylla, Anti-inflammatory, Protein denaturation, RSM, Protein denaturation https://www.ijper.org/metal-complexes-of-curcumin-a-comprehensive-approach-to-design-synthesis-charact 2026-04-13T05:54:09.781339+00:00 Metal Complexes of Curcumin: A Comprehensive Approach to Design, Synthesis, Characterization and Assessment of Anti-tubercular Activity 2024-08-08 10.5530/ijper.58.3s.96 **Background:** The primary challenge facing Tuberculosis (TB) is the growing prevalence of drug resistance and the hepatotoxicity secondary effects of first and second-line anti-TB treatments have reignited interest in exploring new metal drug complexes as possible sources of anti-TB medications. **Aim:** To perform in silico studies for Curcumin-metal complexes, synthesis and evaluate their antitubercular activity and cytotoxicity. **Materials and Methods:** Designed metal complexes were doc Tuberculosis, Curcumin metal complex, Docking, ADMET studies, MABA assay https://www.ijper.org/aquasome-as-drug-delivery-carrier-in-the-pharmaceutical-field 2026-04-13T05:54:09.781339+00:00 Aquasome: As Drug Delivery Carrier in the Pharmaceutical Field 2024-08-08 10.5530/ijper.58.3s.77 In the pharmaceutical field, various diagnostic tools and delivery systems are available which used for the identification of diseases and treatment. Aquasome is a new type of vesicular drug delivery system. It is a self-assembled nanoparticle with a three-layered structure consisting of a nanocrystalline central core on top of that carbohydrate layer is present that adsorbs the bio-actives or drugs on that layer. A carbohydrate coating protects and preserves the structural integrity of the bioa Aquasome, Vesicular, Nanocrystalline, Three-layered, Self-assembly, Structural integrity https://www.ijper.org/lithotriptic-effect-of-cinnamomum-verum-and-nigella-sativa-on-ureteric-calculi 2026-04-13T05:54:10.977036+00:00 Lithotriptic Effect of Cinnamomum verum and Nigella sativa on Ureteric Calculi 2024-06-21 10.5530/ijper.58.3.93 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-854.pdf **Introduction:** Urolithiasis is one of the most prevailing diseases in the society. Conventional treatments are symptomatic and are not targeted to direct the dissolution of ureteric calculi. Thus, in this study plants like Cinnamomum verum (Lauraceae) (C. verum) and Nigella sativa (Ranunculaceae) (N. sativa) are selected to assess for their lithotriptic activity. **Materials and Methods:** The combinations of hydroalcoholic extract of these plants were prepared (HaNsCv). Ureteric calculi of Antiurolithiatic activity, Ureteric calculi, Cinnamomum verum, Nigella sativa, ex vivo https://www.ijper.org/design-and-synthesis-of-novel-series-of-thiophene-2-5-dicarbohydrazide-derivativ 2026-04-13T05:54:10.977036+00:00 Design and Synthesis of Novel Series of Thiophene-2, 5-dicarbohydrazide Derivatives as Potential Anticancer Agents 2024-06-21 10.5530/ijper.58.3.92 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-837.pdf **Background:** The biological activity of thiophene and carbohydrazide derivatives is well known; some of them are included in various anticancer drugs. **Objectives:** The main goal of this work was to develop effective, effective and non-toxic compounds with anti-cancer properties. To achieve this goal, we synthesized a new series of N2, N5-bis(1E)- ethylidene thiophene-2,5-dicarbohydrazide derivatives. **Materials and Methods:** Thiophene-2,5-dicarbohydrazide reacts with aromatic aldehydes Thiophene-2,5-dicarbohydrazide, Anticancer, MCF-7 cell lines, Derivatives https://www.ijper.org/protective-effect-of-saikosaponin-d-against-streptozotocin-induced-diabetic-neph 2026-04-13T05:54:10.977036+00:00 Protective Effect of Saikosaponin D against Streptozotocin-Induced Diabetic Nephropathy in Rats by Regulating the Oxidative Stress and Inflammatory Markers 2024-06-21 10.5530/ijper.58.3.96 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-882.pdf **Background:** Diabetic Nephropathy (DN) is a common problem in diabetes and is characterized by glomerular dysfunction, hyperfiltration, and ultimately kidney failure. **Objectives:** The present study was intended to understand the salutary activities of Saikosaponin D in the Streptozotocin (STZ)-induced DN model. **Materials and Methods:** 60 mg/kg of STZ was administered to the rats to initiate DN, and they were then treated with Saikosaponin D (10 and 20 mg/kg, respectively) for 10 weeks Diabetic nephropathy, Saikosaponin D, Oxidative stress, Creatinine, Insulin https://www.ijper.org/development-and-validation-of-a-sensitive-fast-and-simple-lc-msms-method-for-the 2026-04-13T05:54:10.977036+00:00 Development and Validation of a Sensitive, Fast and Simple LC-MS/MS Method for the Quantitation of Favipiravir Pure and Tablet Dosage Forms 2024-06-21 10.5530/ijper.58.3.108 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-984.pdf **Objectives:** The analytical method development and validation for the determination of Favipiravir (FVPR) in pure and tablet dosage forms by LC/MS-MS Technique. **Materials and Methods:** A simple LC-MS/MS method was developed for the determination of a new antiviral drug, FVPR in pharmaceutical formulations the separation process was conducted using a Waters X-Bridge Phenyl Hexyl column (150x4.6 mm, 3.5 μm). The elution method employed was isocratic, involving a buffer solution consisting o LC-MS/MS, Favipiravir, Zanamivir, Validation, Analytical method https://www.ijper.org/headspace-spme-gc-ms-analysis-and-in-silico-molecular-docking-studies-of-phytoch 2026-04-13T05:54:10.977036+00:00 Headspace SPME-GC-MS Analysis and in silico Molecular Docking Studies of Phytochemical Compounds Present in Houttuynia cordata Thunb 2024-06-21 10.5530/ijper.58.3.95 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-870.pdf **Aim:** The study aimed to identify the phytochemical constituents present in the leaves, stems, and roots of H. cordata and perform in silico molecular docking studies of selected common compounds present in all three parts. **Materials and Methods:** The phytochemical components were investigated using the headspace solid-phase micro-extraction followed by gas chromatography-mass spectrometry and molecular docking was performed using Autodock Vina v.1.2.0. **Results:** β-pinene was found to Houttuynia cordata, Headspace SPME-GC-MS, in silico molecular docking, β-pinene, Caryophyllene https://www.ijper.org/fabrication-of-biocompatible-transdermal-nanofibrous-patch-for-localized-deliver 2026-04-13T05:54:10.977036+00:00 Fabrication of Biocompatible Transdermal Nanofibrous Patch for Localized Delivery of Lidocaine and Rosemary Oil to Improve Effective Management of Lymphoma Pain and Nursing Care 2024-06-21 10.5530/ijper.58.3.85 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-771.pdf **Background:** The primary goal of the current investigation is to fabricate a transdermal NFs patch-based drug delivery system using Poly-N-Vinyl Caprolactam (PNVCL) blended with sodium alginate to prepared transdermal nanofibrous patch for lymphoma pain and nursing care, with lidocaine and Rosemary oil, as supportive drugs for pain management. **Materials and Methods:** The local anaesthetic Lidocaine (LP) and natural drug Rosemary Oil (RO) were loaded into the temperature transition phase o Transdermal patch, Lidocaine, Rosemary oil, Lymphoma pain, Nursing care https://www.ijper.org/evaluation-of-clinical-diagnosis-effect-of-intracranial-aneurysms-combined-with 2026-04-13T05:54:10.977036+00:00 Evaluation of Clinical Diagnosis Effect of Intracranial Aneurysms Combined with Artificial Intelligence Assistant Diagnosis System 2024-06-21 10.5530/ijper.58.3.105 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-954.pdf **Objectives:** An intracranial aneurysm, usually referred to as an abnormal bulge in the wall of an intracranial artery, is the number one cause of subarachnoid hemorrhage and ranks third among cerebrovascular accidents after cerebral thrombosis and hypertensive cerebral hemorrhage. Head CT Angiography (CTA), magnetic resonance Magnetic Resolution Imaging (MRI) and Digital Subtraction Angiography (DSA) are currently common diagnostic methods. Artificial Intelligence (AI) is a new interdisciplin Intracranial Aneurysms, Clinical Diagnostic Effect, Artificial Intelligence, Auxiliary Diagnostic System https://www.ijper.org/nephroprotective-activity-of-marrubiin-against-cisplatin-induced-nephrotoxicity 2026-04-13T05:54:10.977036+00:00 Nephroprotective Activity of Marrubiin against Cisplatin-induced Nephrotoxicity in Albino Male Wistar Rats 2024-06-21 10.5530/ijper.58.3.98 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-899.pdf **Background:** One of the most effective anti-cancer medications used to treat various cancers is Cisplatin (CP). Due to its nephrotoxicity, its usage is restricted. The purpose of this investigation is to assess Marrubiin’s influence in the protection of rats against CP nephrotoxicity. **Materials and Methods:** Animals were divided into five groups. The body weight and kidney weight were measured for all the experimental groups. Urine output and blood samples were collected to assess the Blo Cisplatin, Marrubiin, Nephrotoxicity, Oxidative marker https://www.ijper.org/methodology-and-results-analysis-of-effect-and-economic-evaluations-related-to-p 2026-04-13T05:54:10.977036+00:00 Methodology and Results Analysis of Effect and Economic Evaluations Related to Pharmaceutical Care Practice in China: A Recent Review 2024-06-21 10.5530/ijper.58.3.80 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-722.pdf **Background:** To evaluate the value of pharmaceutical care, and sort out the existing problems in the current researches. **Materials and Methods:** We established the research strategy and searched seven databases. Two reviewers independently screened the studies, extracted data, conducted the statistical analysis and assessed the quality of full economic evaluations. The pharmaceutical care was divided into 9 types based on the relevant standards of Chinese Hospital Association. **Results: Review, Pharmaceutical care, Effect, Economic evaluation, Methodology https://www.ijper.org/synthesis-and-antinociceptive-activity-of-5-amino-n-substitutedcarboxamidequinol 2026-04-13T05:54:10.977036+00:00 Synthesis and Antinociceptive Activity of 5-Amino (N-Substitutedcarboxamide)quinoline Derivatives Targeting TRPV1 Receptor 2024-06-21 10.5530/ijper.58.3.107 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-976.pdf **Background:** Quinoline is a significant heterocyclic moiety involved in several biological activities including inhibition of transient receptor potential vanilloid 1. **Materials and Methods:** A series of 5-amino( N-substituted carboxamide)quinoline derivatives (2o-2t) were synthesized through two steps. FT-IR, 1H NMR and mass spectrum techniques were used to confirm these obtained derivatives. Using acetic acid-induced writhing in rats, all the compounds were tested for TRPV1 inhibition b Quinoline, Antinociceptive, TRPV1, Acetic acid, Histopathology https://www.ijper.org/an-umbelliferone-induced-caspase-mediated-apoptosis-in-mda-mb-231-breast-cancer 2026-04-13T05:54:10.977036+00:00 An Umbelliferone-induced Caspase-Mediated Apoptosis in MDA-MB-231 Breast Cancer Cells 2024-06-21 10.5530/ijper.58.3.97 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-890.pdf **Background:** A highly malignant tumor, Breast Cancer (BC) has a poor prognosis for patients with the highest mortality rates in women. BC is currently treatable with a limited number of therapeutic strategies. **Aim:** Natural compounds with anti-proliferative capabilities are gaining popularity as a way to mitigate the toxicity of radiation and synthetic anti-tumor drugs. Umbelliferone has been reported to possess diverse pharmacological activities, like anti-cancer, anti-inflammation and a Breast cancer, Umbelliferone, MDA-MB-231 cells, Apoptosis, Reactive oxygen species https://www.ijper.org/plumbago-indica-l-root-extract-induces-anti-proliferation-anti-migration-and-apo 2026-04-13T05:54:10.977036+00:00 Plumbago indica L. Root Extract Induces Anti-proliferation, Anti-migration and Apoptosis on the Human Lung Cancer Cell Line 2024-06-21 10.5530/ijper.58.3.94 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-861.pdf **Background:** Plumbago indica L. (PI) is a Thai traditional medicine that has been reported to improve health benefit including anticancer property. Nevertheless, the effects of PI and this mechanism are still less data in lung cancer. **Aim:** To investigate and compare the effects of PI root extract with high and low active compound, plumbagin, on the growth inhibition and apoptotic induction in A549 lung cancer cells with underlying mechanism. **Materials and Methods:** Antiproliferative Plumbago indica (PI), Apoptosis, Anti-proliferation, Human lung cancer cell line, Migration, Mitochondrial function https://www.ijper.org/selection-of-teaching-faculty-in-pharmacyengineering-institutes-by-using-an-anal 2026-04-13T05:54:10.977036+00:00 Selection of Teaching Faculty in Pharmacy/Engineering Institutes by Using an Analytical Hierarchy Process (AHP): A Procedure Proposed 2024-06-21 10.5530/ijper.58.3.103 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-940.pdf **Background:** The process for choosing the right talent to further the institution’s objectives is known as faculty selection. In a pharmacy or engineering college, choosing teaching personnel is quite important. The best-qualified candidates for teaching faculty members in pharmacy/ engineering institutions are chosen in this study using an Analytical Hierarchy Process (AHP). **Materials and Methods:** AHP analysis is done based on six primary criteria as Ph.D./M. Tech (P/M), Teaching Experi Analytical hierarchy process, Teaching experience, Industry experience, Weight matrix, Random consistency index https://www.ijper.org/evaluation-of-pomegranate-seed-extract-as-a-tyrosinase-inhibitor-for-hyperpigmen 2026-04-13T05:54:10.977036+00:00 Evaluation of Pomegranate Seed Extract as a Tyrosinase Inhibitor for Hyperpigmentation Treatment 2024-06-21 10.5530/ijper.58.3.106 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-965.pdf **Background:** Melanin is a natural pigment found in various parts of the human body, which gives our skin, hair and eyes their color and protects the skin from ultraviolet light. Hyperpigmentation refers to a common skin condition in which the appearance of darker patches of skin compared to surrounding areas is observed. Tyrosinase inhibitors are able to control the overactivity of tyrosinase. These compounds inhibit the activity of the tyrosinase enzyme and help fade dark spots, melasma and Melanin, Tyrosinase, Hyperpigmentation, Tyrosinase inhibitors, Ascorbic acid, Beta sitosterol, Ellagic acid, Gallic acid https://www.ijper.org/validated-stability-indicating-hptlc-method-development-for-rivaroxaban-in-table 2026-04-13T05:54:10.977036+00:00 Validated Stability Indicating HPTLC Method Development for Rivaroxaban in Tablets 2024-06-21 10.5530/ijper.58.3.100 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-918.pdf **Objectives:** The present goal of this analytical study is to develop a simple, reliable, sensitive and robust method that can identify Rivaroxaban (RVB) by using high performance thin liquid chromatography. The current study included a degradation study by using different stress conditions in drug and tablets by using HPTLC. **Materials and Methods:** The analysis was performed by using the HPTLC CAMAG system compromising Linomat 5 sample applicator at wavelength 284 nm. Mobile phase selecte Rivaroxaban, Tablets, HPTLC, Validation, Stability study https://www.ijper.org/development-of-nanosponge-formulations-of-rosuvastatin-for-oral-delivery-using-a 2026-04-13T05:54:10.977036+00:00 Development of Nanosponge Formulations of Rosuvastatin for Oral Delivery Using a Central Composite Design 2024-06-21 10.5530/ijper.58.3.86 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-784.pdf **Background:** Rosuvastatin (ROS) is an anti-hyperlipidaemic drug which reduces cholesterol levels, having poor solubility and low bioavailability (<20%). The objective of the present study was to increase ROS bioavailability by formulating nanosponges. **Materials and Methods:** Important quality features were identified using the Quality by Design (QbD) method. Central Composite Design (CCD) was utilized to design formulations. Eudragit L-100 (EL-100) and Polyvinyl Alcohol (PVA) were used as Rosuvastatin, In vivo drug release, Central Composite Design, Eudragit L-100, Quality by Design https://www.ijper.org/application-of-mechanistic-pharmacokinetic-model-for-the-optimization-of-metform 2026-04-13T05:54:10.977036+00:00 Application of Mechanistic Pharmacokinetic Model for the Optimization of Metformin Delayed Release Dosage Form for Intestinal Targeting 2024-06-21 10.5530/ijper.58.3.109 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-991.pdf **Background:** Metformin (MET) is a widely prescribed drug for managing Type 2 Diabetes Mellitus (T2DM). Despite the rich clinical experience and advantages, the clinical utility of MET in renal failure patients is limited because of the treatment-related side effects. A novel colon-targeted MET Delayed-Release (DR) dosage form could be a lucrative option for managing T2DM in renal failure patients. MET DR tablets have minimum systemic exposure and are believed to have the same efficacy as othe Metformin, Delayed release, Renal failure, PBPK, Pharmacokinetics, Optimization https://www.ijper.org/effects-of-bifidobacterium-quadruple-viable-tablets-combined-with-immune-enhanci 2026-04-13T05:54:10.977036+00:00 Effects of Bifidobacterium Quadruple Viable Tablets Combined with Immune-Enhancing Enteral Nutritional Adjuvant Therapy on Intestinal Flora, Intestinal Mucosal Barrier and Immune Function in Elderly Patients with Hepatitis B Cirrhosis 2024-06-21 10.5530/ijper.58.3.90 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-822.pdf **Objectives:** Hepatitis B cirrhosis is a serious condition caused by the hepatitis B virus, leading to liver fibrosis and vascular proliferation. Current clinical treatments still have limitations, prompting interest in microecological agents and immune-enhancing nutrition. Recent studies indicated the crucial role of intestinal flora imbalance in cirrhosis development, which might be modulated by the “liver-gut” axis. Therefore, this study aimed to investigate the impact of integrating microe Microecological agents, Enteral nutrition, Chronic hepatitis B, Liver cirrhosis https://www.ijper.org/qsar-based-drug-repurposing-a-new-paradigm-in-breast-cancer-research 2026-04-13T05:54:10.977036+00:00 QSAR Based Drug Repurposing: A New Paradigm in Breast Cancer Research 2024-06-21 10.5530/ijper.58.3.78 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-695.pdf Breast carcinoma is the world’s most prevalent type of cancer.The building of predictive cytotoxicity breast cancer models assists permanent synthetic activities and give critical information about structure-activity of novel structure design through a quantitative Structure-Activity Relationship (QSAR) modelling application. Quantitative Structure-Activity Relationships (QSAR) present a model that links pharmacological and biological activities to chemical structures and molecular docking resea Breast carcinoma, MCF-7 cell line, 2-phenylacrylonitriles, QSAR, Model development, Drug design, Anti-cancer https://www.ijper.org/simultaneous-estimation-of-cal-dl-2-hydroxy4-methyl-thio-butyrate-and-ca-2-oxo3 2026-04-13T05:54:10.977036+00:00 Simultaneous Estimation of Cal DL-2-Hydroxy,4-methyl thio-butyrate and Ca-2-oxo3-phenyl Propionate in Alpha-Ketoanalogues Tablets by Validated RP-HPLC Method 2024-06-21 10.5530/ijper.58.3.96 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-925.pdf **Introduction:** Alpha-Ketoanalogues is a dietary supplement drug containing Calcium-DL- 2-hydroxy-4-(methylthio) butyrate (CHMTB) and Calcium-2-oxo-3-phenyl propionate (COPP) for the management of chronic renal disease. **Objectives:** In this study, a simple RP-HPLC method has been developed to simultaneously determine Calcium-DL-2-hydroxy-4-(methylthio) butyrate (CHMTB) and Calcium-2-oxo-3-phenyl propionate (COPP) in Alpha-Ketoanalogues Tablets. **Materials and Methods:** The compounds wer Alpha-Ketoanalogues, Chronic kidney disease, Chromatography, Method Validation, Simultaneous estimation, Formulation https://www.ijper.org/a-systematic-review-on-association-of-oxidative-stress-in-rheumatoid-arthritis-b 2026-04-13T05:54:10.977036+00:00 A Systematic Review on Association of Oxidative Stress in Rheumatoid Arthritis Based on Cross-Sectional Case-Control Studies 2024-06-21 10.5530/ijper.58.3.79 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-709.pdf **Background:** Rheumatoid Arthritis (RA) is a chronic form of inflammatory disorder where the immune system causes the destruction of bones and cartilage in joints and impacts the quality of life. Few studies have explored the possibility of the involvement of oxidative stress markers in the pathophysiological process of disease progression in RA as well as the beneficial effect of antioxidants. It was discovered that no systematic review had been carried out to support this idea over the previ Rheumatoid Arthritis, Biomarkers, Malonandehyde, ROS, Oxidative Stress, SOD https://www.ijper.org/the-development-formulation-and-assessment-of-polyelectrolytic-complexes-of-an-a 2026-04-13T05:54:10.977036+00:00 The Development, Formulation, and Assessment of Polyelectrolytic Complexes of an Anticancer Compound (Vinorelbine Tartarate) 2024-06-21 10.5530/ijper.58.3.84 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-760.pdf **Introduction:** Vinorelbine tartrate is used as a first-line treatment in conjunction with conventional treatments, especially advanced disease including cancer patients. **Objectives:** The objective of the study was to develop a polyelectrolyte complex carrier system for Vinorelbine tartarate used for the treatment of Cancer. **Materials and Methods:** Polyelectrolyte Complex (PEC) was prepared using entrapment method using gum Kondagogu and chitosan as polymers. Materials and Methods: Vin Anticancer agent, Polyelectrolyte complex, Vinorelbine tartarate, Gum Kondagogu and Chitosan https://www.ijper.org/inhibiting-cancer-progression-through-targeting-hdac2-with-novel-ligands-a-dynam 2026-04-13T05:54:10.977036+00:00 Inhibiting Cancer Progression through Targeting HDAC2 with Novel Ligands: A Dynamic Insights through Virtual Screening and Simulation 2024-06-21 10.5530/ijper.58.3.88 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-802.pdf **Background:** Cancer is a multifaceted disease characterized by uncontrolled cell growth and represents a significant global health challenge. The intricate origins of cancer involve various factors that may act independently or collectively, contributing to its initiation and progression and resulting in the dynamic nature of the disease. **Aim:** The current focus of research is to elucidate the role of histone acetylation in cancer progression. **Materials and Methods:** A key area of int HDAC2, Cancer, RMSD, SBVS, MD Simulation https://www.ijper.org/comparison-of-normal-saline-activated-charcoal-and-intravenous-lipid-emulsion-in 2026-04-13T05:54:10.977036+00:00 Comparison of Normal saline, Activated Charcoal and Intravenous Lipid Emulsion in a Rat Model of Colchicine Overdose: Experimental Study 2024-06-21 10.5530/ijper.58.3.87 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-794.pdf **Aim:** The aim of this study is to investigate the effects of Normal Saline (NS), Activated Charcoal (AC) and Intravenous Lipid Emulsion (ILE) in colchicine poisonings that resulted in death. **Study Design:** The research is an experimental study carried out in a medical school animal laboratory. **Materials and Methods:** 24 female Sprague-Dawley rats were divided into 4 equal groups. After giving Colchicine (1 mg/kg, PO) to all animals, different treatments (NS, AC, ILE) were given to 3 g Colchicine overdose, intoxication, Normal saline, Activated charcoal, intravenous lipid emulsion https://www.ijper.org/a-novel-targeted-nanoliposomal-atorvastatin-transdermal-patch-assisted-with-soli 2026-04-13T05:54:10.977036+00:00 A Novel Targeted Nanoliposomal Atorvastatin Transdermal Patch Assisted with Solid Microneedles for Improved Bioavailability 2024-06-21 10.5530/ijper.58.3.82 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-736.pdf **Objectives:** The present study investigated the alternate route of delivery to avoid first pass metabolism and to increase bioavailability by nanosized Liposomes (LP) with Microneedles (MNs) Assistance for the Delivery of Atorvastatin (AVT), a HMG CoA reductase inhibitor in which the role of commercial Epyz derma Roller (poke and patch) MN arrays containing 540 Titanium Microneedles (MNs) with dissimilar micro-needle lengths (0.25, 0.5, 1.5, 2.5 mm) in improving the in vitro permeation of AVT Liposomes, Atorvastatin, Microneedles, Transdermal drug delivery systems, Bioavailability, Anti hyperlipedemic https://www.ijper.org/tablet-compression-optimization-of-ivabradine-sustained-release-tablet-using-ful 2026-04-13T05:54:10.977036+00:00 Tablet Compression Optimization of Ivabradine Sustained-Release Tablet Using Full Factorial Design 2024-06-21 10.5530/ijper.58.3.81 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-730.pdf **Aim:** This study aimed to qualitatively identify the ranges of the factors involved in the tablet compression process for ivabradine Sustained Release (SR) tablets. **Materials and Methods:** A full factorial design of experiments study was used to identify three factors (pre- and main-compression force and paddle rotation time) involved in the compression process of ivabradine SR tablets. For robust tableting, three responses (content uniformity, friability, and dissolution) were evaluated Design of experiment, Ivabradine, Quality by design, Sustained-release tablet https://www.ijper.org/safe-and-effective-anticoagulation-with-warfarin-within-one-year-time-period-tea 2026-04-13T05:54:10.977036+00:00 Safe and Effective Anticoagulation with Warfarin within One-year Time Period- Team Work of Healthcare Professionals 2024-06-21 10.5530/ijper.58.3.104 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-949.pdf **Background:** At the study site, Quality team found many incident reports of bleeding due to increased INR in patients on Warfarin anticoagulation therapy. These patients were unaware about adverse effects of anticoagulation therapy and drug-drug/food-drug interactions. Hence to ensure safety in anticoagulation with Warfarin, team of a Pharmacologist, Clinical Pharmacist and Quality manager decided to conduct a clinical audit to improve high alert medication safety with warfarin. **Materials Clinical Pharmacists, Audit, Warfarin, Interventions https://www.ijper.org/design-and-characterization-of-timolol-loaded-gellan-gum-nanoparticles-for-impro 2026-04-13T05:54:10.977036+00:00 Design and Characterization of Timolol Loaded Gellan Gum Nanoparticles for Improved Ocular Drug Delivery 2024-06-21 10.5530/ijper.58.3.83 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-751.pdf **Aim:** Glaucoma treatment often involves the topical application of Timolol maleate (TM) to the eye. However, achieving the desired bioavailability via the ocular route can be challenging due to poor retention and penetration of the drug. To address this issue, Gellan Gum (GG) polymer was employed in the current research to formulate nanoparticles of TM to enhance its release during ocular delivery. **Materials and Methods:** TM loaded GG Nanoparticles (TMNPs), were formulated by ionotropic g Nanoparticles, Glaucoma, Timolol maleate, Gellan gum, Biopolymer https://www.ijper.org/anticancer-and-hepatoprotective-role-of-selenium-nanoparticles-against-liver-car 2026-04-13T05:54:10.977036+00:00 Anticancer and Hepatoprotective Role of Selenium Nanoparticles against Liver Carcinogen Acrylamide Induced Toxicity: In vitro and in vivo Studies 2024-06-21 10.5530/ijper.58.3.91 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-830.pdf **Background and Objectives:** Selenium is considered one of the essential components of many enzymes, particularly the antioxidant enzymes such as thioredoxin reductase. Vegetables, among other food sources, are common sources of selenium. In the present study, the green synthesis of Selenium nanoparticles (SeNPs) from Ocimum basilicum’ aerial part was carried out, as were the anticancer and hepatoprotective roles of selenium nanoparticles against liver carcinogen acrylamide-induced toxicity. Selenium nanoparticles (SeNPs), Green synthesis, Acrylamide, Cytotoxic activity, Hepatoprotective, Anticancer https://www.ijper.org/the-postgraduate-community-pharmacy-education-system-commentary-on-the-swiss-sys 2026-04-13T05:54:10.977036+00:00 The Postgraduate Community Pharmacy Education System: Commentary on the Swiss System 2024-06-21 10.5530/ijper.58.3.110 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-1002.pdf Postgraduate education is recognized to improve communication and clinical skills and to have a positive impact on pharmacists’ professional activities and responsibilities. The purpose of this commentary is to present the Swiss postgraduate education model. In Switzerland, since 2018, an authorization to practice independently requires completion of a Federal Specialized Postgraduate Diploma (FSPD). A motivating factor for pharmacists to complete the FSPD is to be authorized to bear more profes Community pharmacy, Postgraduate Education, Education Requirements, Competency-Based Education, Legislation, Pharmacy https://www.ijper.org/association-between-clinical-case-validation-and-students-success-rate-in-virtua 2026-04-13T05:54:10.977036+00:00 Association between Clinical Case Validation and Students’ Success Rate in Virtual Pharmacy Simulation 2024-06-21 10.5530/ijper.58.3.102 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-931.pdf **Background:** Virtual simulation has been widely used in various pharmacy educational institutions worldwide, and it helps students approach the real-world pharmacy practice experience. However, the importance and practice of validating clinical cases among pharmacy educators still need to be improved. **Objectives:** To assess the correlation between the success rate of students with reliability statistics, Exploratory Factor Analysis (EFA), and Confirmatory Factor Analysis (CFA). **Materia Correlation, Confirmatory factor analysis, Exploratory factor analysis, MyDispense, Pass percentage of students, Reliability statistics, Virtual simulation https://www.ijper.org/mettl14-mediate-the-biological-effects-of-emt-in-bladder-cancer-cells-by-methyla 2026-04-13T05:54:10.977036+00:00 METTL14-Mediate the Biological Effects of EMT in Bladder Cancer Cells by Methylating SOX4 mRNA with m6A 2024-06-21 10.5530/ijper.58.3.89 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-814.pdf **Objectives:** Bladder Cancer (BC) is one of the most common malignant tumours of urinary system, with high rates of metastasis and mortality. Methyltransferase-like 14 (METTL14) is an RNA N6-adenosine methyltransferase that can affect the development of tumours by modifying RNA expression. The study aims to uncover the molecular mechanism and biological function of METTLI4 in BC. **Materials and Methods:** qRT-PCR assays were employed METTL14 in BC cell lines. MeRIP-qPCR and RIP were used to METTL14, EMT, Bladder cancer, SOX4 mRNA, m6A https://www.ijper.org/development-and-validation-of-a-novel-second-derivative-uv-method-for-the-estima 2026-04-13T05:54:10.977036+00:00 Development and Validation of a Novel Second Derivative UV Method for the Estimation of Antihypertensive Drugs in Tablet Dosage Form 2024-06-21 10.5530/ijper.58.3.99 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-3-908.pdf **Aim:** The objective of the current work was to develop and statistically validate a second order derivative method for estimating atenolol in tablet dosage form using UV spectrophotometry. **Materials and Methods:** The method validation was done in accordance with ICH recommendations. Atenolol (BSC class III) and hydrochloride (BSC class II) were soluble in 0.1 N NaOH and gave stable absorbance with it, hence 0.1 N NaOH was chosen as a solvent. The wavelengths selected were 226 nm and 274 n Atenolol, Hydrochlorthiazide, UV spectroscopy, Second derivative, ICH guidelines https://www.ijper.org/synthesis-of-curcumin-loaded-complex-coacervate-of-chitosan-phosphate-and-sodium 2026-04-13T05:54:12.268468+00:00 Synthesis of Curcumin-Loaded Complex Coacervate of Chitosan Phosphate and Sodium Alginate and Study of their Antibacterial Activity 2024-05-27 10.5530/ijper.58.2s.45 **Background:** In a system of two oppositely charged colloids a spontaneous liquid-liquid phase separation is termed as complex coacervation and the separated phase is called coacervate. In recent times coacervates prepared from different colloidal systems have found extensive uses in the microencapsulation of bioactive molecules including drugs. The search for new coacervation systems and coacervates with novel properties remains an active area of research. In the present work preparation of c Curcumin, Chitosan Phosphate, Sodium Alginate, Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumonia, Enterobacter aerogenes https://www.ijper.org/in-vitro-antibacterial-evaluation-and-in-silico-docking-of-schiff-base-as-a-pote 2026-04-13T05:54:12.268468+00:00 In vitro Antibacterial Evaluation and in silico Docking of Schiff Base as a Potential Inhibitor of Nucleoside Diphosphate Kinases 2024-05-27 10.5530/ijper.58.2s.54 **Aim:** Schiff bases are vital Compounds of organic chemistry; they have exhibited more potential biological activities namely antiviral, antibacterial, and antifungal characteristics. Molecular docking studies suggested that strong binding energies, as well as favorable hydrogen bonds and hydrophobic interactions, could be beneficial for the pharmacological application of the compounds. Moreover, the aid of the ADMET score may support the therapeutic action of potential pharmaceutical compound Antibacterial Study, Schiff base ligand, Escherichia coli, Staphylococcus aureus, Molecular Docking https://www.ijper.org/the-fast-and-simple-lc-msms-method-for-determination-of-rifampicin-in-the-human 2026-04-13T05:54:12.268468+00:00 The Fast and Simple LC-MS/MS Method for Determination of Rifampicin in the Human Blood Plasma 2024-05-27 10.5530/ijper.58.2s.60 **Background:** Rifampicin is an important anti tuberculosis drug for the early infection and, more importantly, bactericidal activity against mycobacterium tuberculosis. LC-MS/MS, with the required molecular specificity, provides quantitative method to rapidly differentiate between the drugs and their metabolites. **Aim:** The current study represents the fast and simple LC-MS/MS method for determination of rifampicin in the human blood plasma. **Materials and Methods:** The plasma samples co Rifampicin, LC-MS/MS, Protein precipitation, Acetonitrile https://www.ijper.org/development-and-validation-of-a-stability-indicating-hptlc-method-for-simultaneo 2026-04-13T05:54:12.268468+00:00 Development and Validation of a Stability Indicating HPTLC Method for Simultaneous Estimation of Telmisartan and Gallic Acid as per ICH Q1A (R2) 2024-05-27 10.5530/ijper.58.2s.67 **Background:** A simple, selective and sensitive HPTLC method was developed for simultaneous estimation of Telmisartan (TEL) and Gallic acid (GA). Oxidative stress produces hypertension, GA having antioxidative property that reduces ROS. TEL is safer angiotensin-1 receptor blocker. **Objectives:** Literatures suggest antioxidant with cardiovascular drug produce synergistic effect. **Materials and Methods:** The stationary-phase used was aluminium-backed silica gel 60F254 HPTLC plates (20 cm×1 Method development and validation, Telmisartan, HPTLC, Gallic acid, Forced degradation study https://www.ijper.org/an-exploration-of-chrysin-fabricated-silver-nanoparticles-as-antibiofilm-agent-a 2026-04-13T05:54:12.268468+00:00 An Exploration of Chrysin Fabricated Silver Nanoparticles as Antibiofilm Agent against Pseudomonas aeruginosa 2024-05-27 10.5530/ijper.58.2s.46 **Background:** Pseudomonas aeruginosa (P. aeruginosa) is the source of serious nosocomial infections, the most common of which is ventilator-associated pneumonia. P. aeruginosa infections continue to pose a substantial therapeutic problem. The expression of several virulence genes and the formation of biofilms in bacteria are caused by quorum sensing, a density-dependent cell-to-cell communication mechanism. Anti-biofilm chemicals prevent the synthesis of the polymer matrix, limit cell adhesion Chrysin, Nanoparticle, P. aeruginosa, Antibiofilm, Quorum sensing https://www.ijper.org/evaluation-of-the-feasibility-of-transdermal-delivery-of-neratinib-nb-loaded-mic 2026-04-13T05:54:12.268468+00:00 Evaluation of the Feasibility of Transdermal Delivery of Neratinib (NB) Loaded Microneedles to Treat Breast Cancer 2024-05-27 10.5530/ijper.58.2s.43 **Background:** Breast cancer is the world’s second-largest leading cause of death in women. Targeting highly localized tumors using transdermal microneedle drug delivery can be highly advantageous in treating breast cancer. **Aim:** The present study evaluates the feasibility of transdermal delivery of promising chemo preventive agent tyrosine kinase inhibitor Neratinib (NB) and physicochemical properties through breast skin and mammary papilla. **Materials and Methods:** The Microneedles (MN Breast cancer, Microneedles, Tyrosine kinase inhibitors, Transdermal delivery, Neratinib https://www.ijper.org/a-comparative-phytochemical-characterization-of-moringa-oleifera-plant-parts-by 2026-04-13T05:54:12.268468+00:00 A Comparative Phytochemical Characterization of Moringa oleifera Plant Parts by Different Solvent Extraction 2024-05-27 10.5530/ijper.58.2s.69 **Background:** M. oleifera is an enriched plant with a variety of rich ingredients that play a very important part in the human diet. Thus, scientists have great interest in assessing the medicinal value of the plant to promote the preparation of new and advanced drugs. Hence, the preparation of plant extracts for experimental purposes is an initial step and key to achieving a quality research outcome. **Materials and Methods:** The primary objective of this study was to evaluate the screening Moringa oleifera, Phytochemical, Antioxidant, Traditional medicine, Extraction yield https://www.ijper.org/a-validated-simple-rapid-and-accurate-rp-hplc-approach-for-measuring-vardenafil 2026-04-13T05:54:12.268468+00:00 A Validated Simple, Rapid and Accurate RP-HPLC Approach for Measuring Vardenafil Hydrochloride Trihydrate in Bulk Drugs and Medicinal Formulations 2024-05-27 10.5530/ijper.58.2s.55 **Background:** Shortcomings in current analytical methods characterized by time-consuming procedures, limited sensitivity, and high costs associated with reagents and instruments, influence the research background. **Objectives:** The goal of this research was to find a simple, fast, and accurate way to discern and quantify substances in bulk drugs and finished products at the utmost minimal levels of detection and quantification. **Materials and Methods:** The methodology involved using a C1 RP-HPLC, Vardenafil hydrochloride Trihydrate, LOD, Nanogram https://www.ijper.org/implementation-of-national-education-policy-2020-in-pharmacy-education 2026-04-13T05:54:12.268468+00:00 Implementation of National Education Policy 2020 in Pharmacy Education 2024-05-27 10.5530/ijper.58.2s.38 Precise and explicit education policy is requisite for a country at all education levels because education ushers to evolution of balance between economy and growth. India with the direction of current Prime Minister and a skilled team with members of diverse backgrounds have developed and planned to implement a new education policy “Indian National Education Policy (NEP-2020)”. NEP-2020 is a pioneering and visionary proposal, framed with the intention to provide a standardized education to ever NEP 2020, Pharmacy, Education policy, Implementation https://www.ijper.org/box-behnkens-design-of-fast-dissolving-ondansetron-buccal-films-and-assessing-th 2026-04-13T05:54:12.268468+00:00 Box Behnken's Design of Fast-Dissolving Ondansetron Buccal Films and Assessing the Impact of Independent Variables on their Swelling and Folding Endurance Constraints 2024-05-27 10.5530/ijper.58.2s.44 **Objectives:** The project intends to create and evaluate oral fast-dissolving Ondansetron (ODN) films and explore how different plasticizers and polymers affect ondansetron release at varied doses. **Materials and Methods:** The solvent casting method was used to make the films. Complex formation and compatibility were evaluated using spectral and calorimetric methods to confirm. Utilising the core composite design, which included 13 different Ondansetron Fast-Dissolving Oral Films (OFDOFs) f Buccal, Design, Evaluation, Folding endurance, Patch, Swelling https://www.ijper.org/formulation-and-evaluation-of-valsartan-tablets-using-starch-succinate-as-novel 2026-04-13T05:54:12.268468+00:00 Formulation and Evaluation of Valsartan Tablets Using Starch Succinate as Novel Super Disintegrant by Using 32 Factorial Design 2024-05-27 10.5530/ijper.58.2s.47 **Aim:** The current study focuses on enhancing the dissolution pace of Valsartan, as BCS Class II. The objective is to develop fast-dissolving tablets of Valsartan by forming complexes with β-Cyclodextrin (β-CD). **Materials and Methods:** To achieve this, Valsartan-βCD (1:1 M) complexes were prepared and used to formulate tablets with the help of primojel and starch succinate, following a 32 design approach. **Results:** The tablet powder blends demonstrated excellent flow properties, making Valsartan, Starch Succinate, Fast Dissolving Tablets, Primojel, Optimization https://www.ijper.org/chlorogenic-acid-a-potential-glucose-6-phosphatase-inhibitor-an-approach-to-deve 2026-04-13T05:54:12.268468+00:00 Chlorogenic Acid, a Potential Glucose-6-Phosphatase Inhibitor: An Approach to Develop a Pre-Clinical Glycogen Storage Disease Type I Model 2024-05-27 10.5530/ijper.58.2s.40 **Introduction:** Gluconeogenesis and glycogenolysis are highly regulated metabolic processes that are critical in maintaining blood glucose levels within the physiological range. Any aberration in the regulation of these processes can lead to an inadequate repository or accumulation of excess glycogen in hepatocytes. Glycogen Storage Disease type I (GSD type I), also known as Von Gierke’s disease, is categorized under inborn errors of metabolism caused due to either inactivity or complete absen Chlorogenic acid, Metformin, Fasting blood glucose, Glucose-6-phosphatase, Glycogen storage disease type I, Glycogenolysis https://www.ijper.org/synthesis-and-biological-evaluation-of-56-dimethylthieno23-dpyrimidin-43h-one-de 2026-04-13T05:54:12.268468+00:00 Synthesis and Biological Evaluation of 5,6-Dimethylthieno[2,3-d]Pyrimidin-4(3H)-One Derivatives as Selective Cyclooxygenase 2 Inhibitors 2024-05-27 10.5530/ijper.58.2s.53 **Background:** NSAIDs are well-established for treating pain, fever, and inflammation mainly by inhibiting inducible Cyclooxygenase 2 (COX-2) isoenzyme. However, most of the marketed NSAIDs non-selectively inhibit physiological COX-1 and exhibit adverse side effects like GI ulcers, renal toxicity, and platelet disorder. Moreover, cardiac side effects also led to the market withdrawal of some of the potential selective COX-2 inhibitors. Thus, several investigations are underway by researchers fr Thieno[2,3-d]pyrimidines, Cyclooxygenase 2 (COX-2) inhibitors, Inflammation https://www.ijper.org/effectiveness-of-complementary-and-alternative-medicine-and-physical-therapies-i 2026-04-13T05:54:12.268468+00:00 Effectiveness of Complementary and Alternative Medicine and Physical Therapies in Peripheral Arterial Disease with Intermittent Claudication: A Systematic Review 2024-05-27 10.5530/ijper.58.2s.37 **Aim/Background:** Peripheral Arterial Disease (PAD) affects the lower limbs. Globally there is a growing disease burden among the patients suffering from cardio-vascular disease and metabolic disorders. The purpose of this review is to generate evidence on the efficacy of CAM therapies in PAD. **Materials and Methods:** This systematic review was performed across the five electronic databases i.e. PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Ovid SP, ISI Web of Science, E Peripheral arterial disease, Complementary medicine, Alternative medicine, Review, Intermittent claudication https://www.ijper.org/cubosome-based-corticosteroidal-drug-delivery-system-for-sustained-ocular-delive 2026-04-13T05:54:12.268468+00:00 Cubosome-based Corticosteroidal Drug Delivery System for Sustained Ocular Delivery: A Pharmacokinetic Investigation 2024-05-27 10.5530/ijper.58.2s.52 **Background:** Fluorometholone is an anti-inflammatory glucocorticoid. It has been used in various ocular inflammatory as well as infectious conditions. Opting for sustained release in ocular drug delivery is a favorable option for managing ocular diseases. To improve efficacy and to overcome side effects, fluorometholone was encapsulated in cubosomal vesicles. **Aim:** In this study, fluorometholone-loaded cubosomal vesicles were prepared using top-down techniques and applying the QbD approac Fluorometholone, Cubosomes, Drug delivery system, Ocular delivery, Quality by Design, Central composite design https://www.ijper.org/stability-indicating-assay-for-the-determination-of-bilastine-in-bulk-drug-and-m 2026-04-13T05:54:12.268468+00:00 Stability Indicating Assay for the Determination of Bilastine in Bulk Drug and Method Development Validation by RP-HPLC Using Analytical Quality by Design Approaches 2024-05-27 10.5530/ijper.58.2s.61 **Background:** Regulatory organizations have acknowledged the need for systematic rules for understanding development as a result of the large increase in concerns and criticism regarding the quality and pharmaceutical products. Bilastine is a second generation antihistamine medication. Generally, it is used for treatment of allergic rhino conjunctivitis and urticaria (hives). **Objectives:** The current study outlines the methodical design and validation of a reversed-phase high-performance l AQbD, Bilastine, Analytical target profile, Critical method attributes, Design of experiments, RP-HPLC, Validation https://www.ijper.org/rapid-cost-effective-and-simple-analytical-method-development-and-validation-for 2026-04-13T05:54:12.268468+00:00 Rapid, Cost Effective and Simple Analytical Method Development and Validation for Simultaneous Estimation of Thymol and Cholecalciferol by Ultraviolet Spectrophotometry 2024-05-27 10.5530/ijper.58.2s.59 **Background:** Thymol and Cholecalciferol in a combined approach can be used as antioxidant, free radical scavenging, anti-depressant, anti-inflammatory, anti-diabetic, anti-arthritis etc. So, rapid, cost effective and simple analytical method is required to estimate Thymol and Cholecalciferol simultaneously in the mixture. **Purpose:** The purpose of this work is to develop and validate Ultraviolet spectroscopic (UV) method for simultaneous estimation of Thymol and Cholecalciferol. **Materia Thymol, Cholecalciferol, UV-visible spectroscopy, Simultaneous equation method development, Q-absorbance ratio method development, Analytical method validation https://www.ijper.org/scientific-validation-of-traditional-detoxification-process-and-evaluation-of-it 2026-04-13T05:54:12.268468+00:00 Scientific Validation of Traditional Detoxification Process and Evaluation of its Impact on Anti-Microbial Potency, Phytochemical and Heavy Metals in Nigella sativa 2024-05-27 10.5530/ijper.58.2s.71 **Background:** Medicinal plants are the best source for a variety of drugs. In traditional practices, the detoxification method is practiced to reduce toxicity of herbs, because low toxicity is one of the characteristics of phytomedicine which have a positive impact on pharmaceutical drugs. **Aim:** In the present study scientific validation attempt has been made to reduce toxicity by performing traditional practices called Sodhana/detoxification. In our study anti-microbial, phytochemical, he Nigella sativa, Lime treatment, Detoxification, Anti-microbial activity, Metal analysis, Heavy Metal Toxicity, Stability https://www.ijper.org/identification-of-phorbol-ester-and-its-degradation-by-traditional-purification 2026-04-13T05:54:12.268468+00:00 Identification of Phorbol Ester and its Degradation by Traditional Purification Method in the Root of Baliospermum montanum (Willd.) Muell. Arg 2024-05-27 10.5530/ijper.58.2s.41 **Background:** Currently five types of phorbol esters are reported in the root of Balliospermum montanum Muell. Here we observed the presence of 12-myristate 13-acetate (C36H56O8) in the root, an additional phorbol ester which restricted its use in food or medicine due to its carcinogenic property. No specific method is reported that can remove or disintegrate the phorbol esters in Balliospermum montanum Muell. root. **Aim:** Identification of 12 myristate13 acetate phorbol ester (C36H56O8) in Phorbol esters, 12 myristate13 acetate, Baliospermum montanum, putpak, Traditional, Detoxification, Purification https://www.ijper.org/enhanced-bioavailability-of-valsartan-through-mucoadhesive-pellets-fabricated-vi 2026-04-13T05:54:12.268468+00:00 Enhanced Bioavailability of Valsartan through Mucoadhesive Pellets Fabricated via Fluidized Bed Processor: A Novel Drug Delivery Approach 2024-05-27 10.5530/ijper.58.2s.49 **Background:** Novel delivery strategies are being explored since low bioavailability presents a challenge for medications like valsartan. Mucoadhesive drug delivery systems present a viable alternative by enhancing drug absorption and retention. **Aim:** This study aimed to develop mucoadhesive drug delivery systems to enhance the bioavailability of valsartan, leveraging a novel mucoadhesive polymer isolated from Samaneasaman seeds. **Materials and Methods:** The study involved formulating o Mucoadhesive drug delivery systems, Valsartan bioavailability, Samaneasaman gum, Sustained drug release, Pharmacokinetic studies https://www.ijper.org/development-and-validation-of-high-performance-thin-layer-chromatographic-method 2026-04-13T05:54:12.268468+00:00 Development and Validation of High-Performance Thin Layer Chromatographic Method for Estimation of Acyclovir 2024-05-27 10.5530/ijper.58.2s.62 **Background:** The antiviral medication genre comprises the synthetic purine nucleoside analogue acyclovir, which particularly is used to treat varicella-zoster and herpes simplex virus infections. By incorporating into viral DNA to stop further synthesis, acyclovir limits DNA synthesis and viral multiplication. The investigation of an economical alternative was spurred by the existence of the currently used HPLC and UV techniques for acyclovir analysis, which are recognized for their solvent-i HPTLC, ICH guidelines, Method development, Acyclovir https://www.ijper.org/rapid-simple-and-low-cost-reverse-phase-high-performance-liquid-chromatography-t 2026-04-13T05:54:12.268468+00:00 Rapid, Simple and Low-Cost Reverse-Phase High-Performance Liquid Chromatography Tool for Estimation of Methotrexate: Testing Application in Standard Laboratory Bulk, Marketed Dosage Form, and Release kinetics in Nanoformulation 2024-05-27 10.5530/ijper.58.2s.64 **Background:** Methotrexate (MTX) is one of the utmost commonly prescribed drugs, which is official in the IP, BP, and USP. MTX is a potent drug that can cause serious side effects if not used in the correct quantity. Assaying MTX is vital to guarantee that the drug exists in the required concentration in the sample. Developing a simple, rapid, and cost-effective analytical tool for its estimation has always been a thrust area of research. In this line, this investigation reports a simple, rapi Methotrexate, Routine analysis, Reverse-phase high-performance liquid chromatography, Estimation, Validation, Application, Standard Laboratory Bulk, Nanoformulation, Marketed Formulation https://www.ijper.org/biogenic-synthesis-of-copper-oxide-nanoparticle-from-aegle-marmelos-and-its-anti 2026-04-13T05:54:12.268468+00:00 Biogenic Synthesis of Copper Oxide Nanoparticle from Aegle marmelos and its Anti-Cancerous Potential against HCT-116 Cell Line 2024-05-27 10.5530/ijper.58.2s.68 **Background and Aim:** Colorectal cancer stands as a frequently occurring fatal disease for several decades and the use of nanoparticles has long been explored in cancer treatments. Engineering the size and shape to attain an optimal efficacy of the nanoparticles and using a specific plant resource to enhance its compatibility to other healthy cell is a propitious approach. The present study investigates the anti-cancer activity of CuO NP synthesized from Aegle marmelos leaf extract against hum Colorectal cancer, Aegle marmelos, Nanoparticles, Copper Oxide, Anti-cancer https://www.ijper.org/assessment-and-comparison-of-greenness-of-uv-spectroscopy-methods-for-simultaneo 2026-04-13T05:54:12.268468+00:00 Assessment and Comparison of Greenness of UV-Spectroscopy Methods for Simultaneous Determination of Anti-Hypertensive Combination 2024-05-27 10.5530/ijper.58.2s.56 **Background:** Environmentally destructive analytical research practices, such as using and releasing hazardous solvents and reagents into the atmosphere, have brought up serious concerns regarding the ecological impact of these actions. By checking greenness of the methods, ecological challenges can be minimized. This gives a brief idea about its extent of effect on environment to the analyst. **Aim:** This work was designed to select the ecofriendly method for the estimation of amlodipine be Green analytical chemistry, Green Metrics, UV-spectroscopy, Eco-friendly, Green solvents https://www.ijper.org/clinical-efficacy-and-safety-of-ceftriaxone-in-surgical-prophylaxis-a-systematic 2026-04-13T05:54:12.268468+00:00 Clinical Efficacy and Safety of Ceftriaxone in Surgical Prophylaxis: A Systematic Review and Meta-Analysis 2024-05-27 10.5530/ijper.58.2s.36 **Introduction:** Adequate antimicrobial monitoring helps identify the changing pattern of infection prevention postoperatively. The review aims at assessing the efficacy and safety of prophylactic ceftriaxone in surgical site infection. **Materials and Methods:** The review followed Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. A systematic search was conducted in PubMed, EMBASE, and CINAHL databases. Randomized control trials, published till December 2022 in E Ceftriaxone, Prophylaxis, Surgical Site Infection https://www.ijper.org/development-of-nanoparticle-based-biodegradable-polymer-composite-film-for-antif 2026-04-13T05:54:12.268468+00:00 Development of Nanoparticle-Based Biodegradable Polymer Composite Film for Antifungal Drug Delivery in Prosthetic Joint Infection 2024-05-27 10.5530/ijper.58.2s.50 **Background:** Fluconazole is an antifungal agent of triazole class. Fluconazole is one of the most prescribed antifungal agents because of its excellent bioavailability, tolerability and side effect profile. To maintain drug concentrations within therapeutic levels in bone tissue for specific periods, antifungal agents must be re-administered when they are given systemically. **Aim:** The aim of the present study was to develop a nanoparticle-based implantable drug delivery system of antifung Fluconazole, Nanoparticles, Chitosan, Implant, Prosthetic joint infection, Composite film https://www.ijper.org/rp-hplc-method-development-and-validation-of-choline-salicylate-and-lignocaine-h 2026-04-13T05:54:12.268468+00:00 RP-HPLC Method Development and Validation of Choline Salicylate and Lignocaine HCl in Mouth Ulcer Gel 2024-05-27 10.5530/ijper.58.2s.63 **Objectives:** The prime intent of the current study is to develop a rapid, reliable, robust and cost-effective reversed-phase HPLC method for simultaneous estimation of Choline Salicylate and Lignocaine HCl in mouth Ulcer Gel. **Materials and Methods:** Buffer was prepared with 3.5 g of disodium hydrogen orthophosphate in 1000 mL of water and adjusted to pH 4.5 with dilute orthophosphoric acid. A mixture of Buffer and Methanol (55:45) containing 0.01M (2.062 g) 1-Hexane Sulphonic acid compris Choline Salicylate, Lignocaine HCl, Sensitivity, Isocratic elution, Specificity https://www.ijper.org/systemic-effect-of-human-follicular-fluid-from-endometriotic-and-healthy-subject 2026-04-13T05:54:12.268468+00:00 Systemic Effect of Human Follicular Fluid from Endometriotic and Healthy Subjects on Female Mice 2024-05-27 10.5530/ijper.58.2s.70 **Aim/Background:** Throughout oogenesis and folliculogenesis, the follicular fluid’s composition alters physiologically to fit the needs of particular microenvironmental demands. This study’s main goal was to compare the effect of follicular fluid collected from endometriotic and non-endometriotic patients on systemic body functioning of female mice. **Materials and Methods:** Both healthy and endometriotic participants’ follicular fluid was collected and pooled separately. Female Swiss albino Biological fluid, Cystic fluid, Endometriotic, Follicular fluid, Ovarian fluid, Systemic effects https://www.ijper.org/quality-by-design-qbd-aided-formulation-optimization-of-amlodipine-besylate-oral 2026-04-13T05:54:12.268468+00:00 Quality by Design (QbD) Aided Formulation Optimization of Amlodipine Besylate Oral Thin Film 2024-05-27 10.5530/ijper.58.2s.48 **Background:** Oral Thin Film (OTF) is an emerging approach for oral drug delivery but still there exists a scarcity of evidence for formulation optimization techniques. Herein, we aim to develop OTFs optimized by the QbD approach. **Materials and Methods:** OTFs were prepared by solvent casting method using Amlodipine as an active ingredient and excipients such as Pectin, Aspartame, Tween 80, and Glycerine. The developed formulation was optimized using QbD software Design Expert version 8.0.4 Oral thin film (OTFs), Solvent casting method, Quality by design (QbD), Optimization, Drug release https://www.ijper.org/quality-by-design-assisted-development-of-fast-dissolving-buccal-film-of-ivabrad 2026-04-13T05:54:12.268468+00:00 Quality by Design Assisted Development of Fast Dissolving Buccal Film of Ivabradine 2024-05-27 10.5530/ijper.58.2s.51 **Background:** Buccal drug delivery is a novel drug delivery system ensure fast onset of action and avoids the first pass metabolism and ultimately improves the bioavailability. **Aim:** The present investigation is oriented towards design and development of Fast Dissolving Buccal Film (FDBF) of Ivabradine HCl (BCS Class I drug) by applying Quality by Design (QbD) concept. **Materials and Methods:** The Quality Target Product Profile was defined for the proposed formulation, CQA’s were identi Ivabradine, Fast Dissolving Buccal Film, Quality by Design, HPMC, Kopulan PG. Risk Assessment https://www.ijper.org/stability-indicating-rp-uplc-method-for-impurity-profiling-of-darunavir-and-rito 2026-04-13T05:54:12.268468+00:00 Stability Indicating RP-UPLC Method for Impurity Profiling of Darunavir and Ritonavir in Fixed Dose Drug Combination Product 2024-05-27 10.5530/ijper.58.2s.58 **Background:** The goal of the proposed study was to develop and validate stability indicating mass compatible reverse phase UPLC method for impurity profiling of Darunavir Ethanolate and Ritonavir degradation impurities in fixed-dose drug combination products. **Materials and Methods:** The optimized chromatographic condition includes use of Zorbax Bonus C18 column (150x2.1 mm, 1.8 μm) with mobile phase A (Buffer (55): Methanol (45)) and mobile phase B (Acetonitrile: (30) and Methanol (70)), Method Validation, Forced degradation, Linearity, Accuracy, Robustness, Impurity profiling https://www.ijper.org/formulation-and-physicochemical-evaluation-of-joshanda-decoction-munzije-balgham 2026-04-13T05:54:12.268468+00:00 Formulation and Physicochemical Evaluation of Joshanda (Decoction) Munzije Balgham as Granules 2024-05-27 10.5530/ijper.58.2s.42 **Background:** Joshanda (decoction) is an effective dosage form in Unani System of Medicine but its unpalatable taste and preparation creates difficulty in patient compliance. Joshanda when freshly prepared has a very short shelf life. Thus, the modified dosage form like granules can fulfill these drawbacks and withstand the need of contemporary life style as a ready to use and in portable form. In this study, an attempt was made to modify Joshanda Munzjie Balgham (JMB) into contemporary granul Decoction, Fast dissolving Granules, Joshanda Munzije Balgham, Wet Granulation https://www.ijper.org/bridging-tradition-and-innovation-the-hail-desert-plant-database-for-drug-discov 2026-04-13T05:54:12.268468+00:00 Bridging Tradition and Innovation: The Hail Desert Plant Database for Drug Discovery 2024-05-27 10.5530/ijper.58.2s.66 **Introduction:** The Hail Desert Plant Database serves as an extensive repository that has been created to consolidate and systematize information concerning medicinal plants that are native to the arid Hail region in Saudi Arabia. **Materials and Methods:** By conducting thorough literature mining from credible sources such as scientific articles and online databases, we systematically collected and organized data on more than 200 desert plant species. This comprehensive dataset includes bota Desert plant database, Disease, Phytochemicals, Docked complex, Target protein https://www.ijper.org/simultaneous-determination-of-amitriptyline-hydrochloride-and-propranolol-hydroc 2026-04-13T05:54:12.268468+00:00 Simultaneous Determination of Amitriptyline Hydrochloride and Propranolol Hydrochloride in Commercial Formulation by Multitudinal UV and Multivariate FT-IR Spectroscopic Methods 2024-05-27 10.5530/ijper.58.2s.57 **Aim:** In the current study, a multivariate FTIR method and two different UV spectrophotometric methods were employed for the simultaneous determination of Amitriptyline Hydrochloride (ATH) and Propranolol Hydrochloride (PPH) in their combined formulation. **Materials and Methods:** The multivariate FTIR method based on the use of Classical Least Squares (CLS) was developed and executed in the lab solutions software for the simultaneous determination of ATH and PPH. CLS model was performed in Classical least squares, Absorbance correction method, Crammer’s matrix method https://www.ijper.org/apoptotic-activity-of-protopine-against-human-breast-cancer-cell-lines-an-in-vit 2026-04-13T05:54:12.268468+00:00 Apoptotic Activity of Protopine against Human Breast Cancer Cell Lines: An in vitro Study 2024-05-27 10.5530/ijper.58.2s.65 **Background:** Breast Cancer continues to rank among all cancer types as the most dangerous malignancies, accounting for a significant portion of cancer-associated mortalities among women globally. Additionally, the number of breast cancer cases that are identified each year is rising globally. After surgery or radiation, the typical therapies entail chemotherapy which is followed by endocrine therapy. However, breast cancer is extremely resistant to therapies, which causes it to recur. As a re Cytotoxicity, Anti-tumor, MDA-MB-231 cells, Breast Cancer, Apopotic Marker https://www.ijper.org/a-biochemical-and-molecular-insight-to-wound-healing-properties-of-traditional-i 2026-04-13T05:54:12.268468+00:00 A Biochemical and Molecular Insight to Wound Healing Properties of Traditional Indian Medicines in Normal and Diabetic Rats 2024-05-27 10.5530/ijper.58.2s.39 **Background:** Honey, ghee, Glycyrrhiza glabra L. (GG), and Nerium indicum Mill. (NI) have been effectively used in Ayurveda and Indian folk medicine for healing both normal and diabetic wounds. However, the exact biochemical and molecular mechanisms involved are less discussed. The present study explores the wound healing efficacy of these traditional medicines in normal and diabetic rats using biochemical and molecular parameters. **Materials and Methods:** Normal and Streptozotocin-induced Wound healing, Honey, Ghee, Glycyrrhiza glabra, Nerium indicum, Diabetic wounds, Antioxidants, Gene expression https://www.ijper.org/evaluation-of-student-performance-based-on-integrated-teaching-method-in-pharmac 2026-04-13T05:54:13.006716+00:00 Evaluation of Student Performance Based on Integrated Teaching Method in Pharmacology Curricula 2024-02-15 10.5530/ijper.58.2.46 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-411.pdf Aim/Background: The transformation of the “new medical education” model imposes higher demands on universities and educators, representing the latest requirements for the development of medical education. In the past decade, continuous innovations in medicine, pharmaceuticals, and information technology have offered multiple convenient avenues for reform and advancement in medical education. To create “golden courses” that align with the demands of the new medical sciences, we are integrating mo New medical construction, Pharmacology education, Integrated teaching method, Medical education, Course reform https://www.ijper.org/diosmetin-methylated-flavonoid-mitigates-ovalbumin-induced-allergic-rhinitis-in 2026-04-13T05:54:13.006716+00:00 Diosmetin, Methylated Flavonoid Mitigates Ovalbumin Induced Allergic Rhinitis in Mice by Attenuating Inflammatory Signaling Proteins 2024-02-15 10.5530/ijper.58.2.77 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-685.pdf Background: Allergic Rhinitis (AR) is a chronic disorder that affects about 15-20% of the global population. In severe cases, AR causes sleep deprivation and impairs work performance and quality of life. Untreated allergic rhinitis may also lead to asthma. Intranasal corticosteroids and oral antihistamines are the most commonly prescribed drugs for allergic rhinitis. The long term intake of these drugs causes various side effects; hence, an alternative drug is required to treat allergic rhinitis Allergic reaction, Ovalbumin, Inflammatory cytokines, Diosmetin, Leukotriene C4 https://www.ijper.org/nasal-administration-of-dolutegravir-loaded-nanoparticles-based-mucoadhesive-in 2026-04-13T05:54:13.006716+00:00 Nasal Administration of Dolutegravir Loaded Nanoparticles Based Mucoadhesive in situ Gel: Design and in vivo Assessment 2024-02-15 10.5530/ijper.58.2.41 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-470.pdf Background: To assess the potential for targeting the brain through intranasal delivery, this study focuses on optimizing and developing a mucoadhesive in situ gel formulation containing Dolutegravir nanoparticles. Materials and Methods: Employing a central composite design, the study optimized the concentration of variables of Hydroxypropyl methylcellulose (HPMC, X1) and Poloxamer 407 (X2) on the gelation temperature (Y1) and drug release (Y2). The optimized drug loaded nanoformulations were as Dolutegravir, in situ gel, Nasal route, Brain, in vivo https://www.ijper.org/effect-of-aqueous-root-extract-of-decalepis-hamiltonii-on-lopinavir-pharmacokine 2026-04-13T05:54:13.006716+00:00 Effect of Aqueous Root Extract of Decalepis hamiltonii on Lopinavir Pharmacokinetics and Midazolam Pharmacodynamics 2024-02-15 10.5530/ijper.58.2.54 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-487.pdf Background: The traditional plant Decalepis hamiltonii, indigenous to southern India, is a key component in the well-known herbal beverage nannari. It has also been utilised as a general vitalizer and paediatric rejuvenator in siddha, ayurveda, and folk medicine. However, it has been demonstrated that this plant's phytoconstituents can modulate CYP450 enzymes, which are crucial for determining the fate of xenobiotics within the body. It has not yet been observed that this plant's modulatory prop Decalepis hamiltonii, Herb-drug interactions, Lopinavir, Midazolam, CYP3A, Pharmacokinetics, Pharmacodynamics https://www.ijper.org/nephroprotective-activity-of-dibenzo-pyrone-derivatives-in-gentamicin-induced-ne 2026-04-13T05:54:13.006716+00:00 Nephroprotective Activity of Dibenzo-α-Pyrone Derivatives in Gentamicin-Induced Nephrotoxicity and Oxidative Stress in Rats 2024-02-15 10.5530/ijper.58.2.69 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-618.pdf Objectives: The current work was done to determine the curative and nephroprotective activities of the synthesized butylamine derivative of Dibenzo-α-Pyrone (DAP). Materials and Methods: The synthesised drug at a concentration of 10, 20, and 40 mg/kg p.o. was given as a single dose in Albino rats with Gentamicin-induced nephrotoxicity. The changes in body weight of animals, if any, were monitored. Biochemical markers like serum creatinine, blood urea, and BUN concentrations were investigated to Dibenzo-α-pyrone, Gentamicin, Nephrotoxicity, Urea, Creatinine, Glutathione, Lipid, peroxidation https://www.ijper.org/novel-substituted-dene-2-13-diphenylallylidene-hydrazine-design-synthesis-and-in 2026-04-13T05:54:13.006716+00:00 Novel Substituted-dene-2-(-1,3-Diphenylallylidene) Hydrazine: Design, Synthesis, and in vitro Microbial Assessment 2024-02-15 10.5530/ijper.58.2.71 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-637.pdf Background: The production of a variety of chalcones (1-Aryl/Alkyl amino substituted-dene-2- (-1,3-diphenylallylidene) hydrazine (ABSa-e) was brought about as a result of the condensation of hydrazide compound and Aryl/Alkyl substituted aldehyde/ ketone in ethanol as a solvent with the help of two drops of conc. hydrochloric acid as a catalyst followed by neutralization. All synthesized derivatives were identified with different spectroscopic techniques and biologically evaluated by microorganis Chalcone, Aldehyde, Antibacterial, Antifungal, Potency https://www.ijper.org/green-synthesis-and-characterization-of-silver-nanoparticles-from-nerium-indicum 2026-04-13T05:54:13.006716+00:00 Green Synthesis and Characterization of Silver Nanoparticles from Nerium indicum and Investigation of Antioxidant and Anti-Cancerous Potential against Cervical Cancer Cell Line (HeLa) 2024-02-15 10.5530/ijper.58.2.63 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-565.pdf Background: Nanotechnology has introduced innovative approaches to clinical applications and drug delivery systems, and among the various nano-materials, AgNPs have garnered significant attention due to their biocompatibility, antibacterial properties, and versatile applications in the medical field. A major cause of cancer related death in women and the fourth most prevalent malignancy worldwide is the cervical cancer, posing a pressing global health challenge. Materials and Methods: In our stu Cytotoxicity, Nerium indicum, Silver nanoparticles, Cervical cancer, Haemolysis, Cell, migration https://www.ijper.org/fabrication-of-topical-pluronic-lecithin-organogel-containing-immunomodulatory-d 2026-04-13T05:54:13.006716+00:00 Fabrication of Topical Pluronic Lecithin Organogel Containing Immunomodulatory Drug for Site-Specific Drug Delivery 2024-02-15 10.5530/ijper.58.2.48 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-432.pdf Background: Rheumatoid Arthritis is an Autoimmune disease, can be categorized by painful joints with limited treatment option. An Oral administration of Leflunomide for longer duration might lead to the Liver Toxicity. Hence, site specific delivery of an Immunomodulatory drug can be proposed for symptomatic relief of pain. Materials and Methods: Present study is focused on the formulation of Leflunomide using Pluronic Lecithin Organogel as a platform to enhance permeation through skin, bypass he Pluronic Lecithin Organogel, 32 full factorial design, Topical application, Rheological, study, Anti-inflammatory activity, Histopathology study https://www.ijper.org/therapeutic-potential-of-withania-somnifera-on-nandrolone-decanoate-induced-gona 2026-04-13T05:54:13.006716+00:00 Therapeutic Potential of Withania somnifera on Nandrolone Decanoate Induced Gonadal Toxicity 2024-02-15 10.5530/ijper.58.2.62 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-555.pdf Background: Nandrolone decanoate (ND) is a commonly used androgen-based steroid that causes adverse effects on illicit self-administered users to boost their physical endurance. Although, it has an anabolic effect on the skeletal muscles, plausible evidence supports that the gonadal toxicity of ND can cause damage to reproductive functions. Aim: The present study investigated the possible protective effects of Withania somnifera (WS) root extract (200 and 400 mg/kg bw) on ND-induced (10 mg/kg bw Nandrolone decanoate, Withania somnifera, Gonadal toxicity, Testosterone, Sperm, count, Sperm motility https://www.ijper.org/natural-and-synthetic-inhibitors-of-heat-shock-protein-90-chaperone-in-cancer-tr 2026-04-13T05:54:13.006716+00:00 Natural and Synthetic Inhibitors of Heat Shock Protein 90 Chaperone in Cancer Treatment 2024-02-15 10.5530/ijper.58.2.45 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-401.pdf The heat shock protein 90 (HSP90) plays a crucial role in regulating cellular homeostasis. Importantly, enhanced dependence of cancer-specific proteins or mutants on HSP90 for their stability and activity offers HSP90 as an attractive therapeutic target. But, HSP90 being an important house-keeping protein, raised skepticism towards achieving cancer-specific therapeutic efficacy. Biochemical and functional studies revealed differential activity of HSP90 between healthy and cancer cells indicating Chaperones, Cancer, Drug resistance, HSP90 inhibitors, Natural products https://www.ijper.org/danshensu-attenuates-diabetes-associated-cognitive-dysfunction-by-markedly-rever 2026-04-13T05:54:13.006716+00:00 Danshensu Attenuates Diabetes Associated Cognitive Dysfunction by Markedly Reversing Oxidative Stress, Aβ and AChE Activity 2024-02-15 10.5530/ijper.58.2.56 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-503.pdf Background: Evidences suggest that the development of neurodegenerative dementia is accelerated by Diabetes Mellitus (DM), a chronic metabolic condition. In Diabetes Mellitus (DM), improper glucose metabolism produces glycotoxins that cause beta-amyloid peptides to build up and cause oxidative damage to neurons in the brain tissue. Aim: This investigation aims to look at the neuroprotective benefits of Danshensu on memory. Materials and Methods: Involving the behaviour model (Morris water maze) Diabetes, Alzheimer’s disease, Oxidative stress, Danshensu, Beta-amyloid, AChE, activity https://www.ijper.org/development-and-evaluation-of-fenofibrate-surface-solid-dispersion-for-improved 2026-04-13T05:54:13.006716+00:00 Development and Evaluation of Fenofibrate Surface Solid Dispersion for Improved Solubility and Dissolution Rate 2024-02-15 10.5530/ijper.58.2.50 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-446.pdf Objectives: The current work aimed to prepare and characterize Surface-Solid Dispersion (SSD) of Fenofibrate (FNB) in order to improve its solubility and dissolution. Materials and Methods: SSD of FNB has been prepared using solvent evaporation techniques through the combination of hydrophilic polymers such as Aerosil 200, Avicel PH 101, Sodium Starch Glycolate (SSG), Crospovidone (CP) and Croscarmellose Sodium (CCS). The produced SSDs were tested for saturation solubility, production yield, Fou FNB, Surface solid dispersion, Solvent evaporation, Solubility, Dissolution rate https://www.ijper.org/pulsatile-drug-delivery-systems-of-esomeprazole-optimization-through-quality-by 2026-04-13T05:54:13.006716+00:00 Pulsatile Drug Delivery Systems of Esomeprazole: Optimization through Quality by Design 2024-02-15 10.5530/ijper.58.2.47 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-417.pdf Background: The current research work was aimed to optimize and develop Pulsatile Drug Delivery Systems (PDDS) of esomeprazole so as to control the nocturnal acid breakthrough in ulcer patients. Materials and Methods: Microparticles separately for Delayed Immediate Release (DIR) and Delayed Extended Release (DER) were developed. DER microparticles were developed as matrix microspheres by optimizing different formulation and process parameters followed by enteric coating of the optimized formulat Pulsatile drug delivery systems, Esomeprazole, Nocturnal acid breakthrough, Central, composite design, Optimization https://www.ijper.org/enhancing-oral-bioavailability-of-isotretinoin-by-using-solid-lipid-nanoparticle 2026-04-13T05:54:13.006716+00:00 Enhancing Oral Bioavailability of Isotretinoin by Using Solid Lipid Nanoparticles (SLNs) 2024-02-15 10.5530/ijper.58.2.51 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-453.pdf Aim: Isotretinoin (ISTN) is a retinoid analogue and known as 13-cis retinoic acid. It is approved for the treatment of Acne vulgaris. Research work was done to improve bioavailability of Isotretinoin by preparing solid lipid nanoparticles and comparison of research formulation with commercially available formulation of Isotretinoin. Central Composite Design (CCD) from response surface methodology was used for test formulation optimisation. Materials and Methods: The test formulation was characte Isotretinoin, Solid Lipid Nanoparticles, Central Composite Design, Response Surface, Methodology, in vitro drug release https://www.ijper.org/comparative-adsorption-of-methyl-orange-color-from-an-aqueous-solution-using-act 2026-04-13T05:54:13.006716+00:00 Comparative Adsorption of Methyl Orange Color from an Aqueous Solution Using Activated Carbon 2024-02-15 10.5530/ijper.58.2.76 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-679.pdf Background and Aim: The study was focused on the adsorption parameters of Methyl Orange dye (MO) onto Commercial Activated Carbon (CAC) in aqueous solution. The examined of parameters in the adsorption process were founded on the optimization. Materials and Methods: Langmuir, Freundlich and Timken models were studied at different temperatures. Time, pH, and adsorbent mass adsorption parameters were examined at 140 mg.L-1 MO dye concentration at 25ºC. PFO and PSO models were studied at 140 mg/L d Methyl Orange (MO), Activated carbon (AC), Thermodynamics, Adsorption isotherm, models, Kinetics models https://www.ijper.org/tgf-2-modulating-anti-apoptosis-effect-of-osteoblasts-by-sodium-fluoride 2026-04-13T05:54:13.006716+00:00 TGF-β2-modulating Anti-apoptosis Effect of Osteoblasts by Sodium Fluoride 2024-02-15 10.5530/ijper.58.2.65 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-589.pdf Objectives: This study aimed to investigate and discuss the mechanism of fluoride-induced osteoblast apoptosis in TGF-β2 signaling pathway. Materials and Methods: The osteoblasts were divided into 0 (control group), 5.0, 10.0, 20.0, and 40.0 mg/L sodium-fluoride induction groups, and the cells were collected after 24 hr and 48 hr induction (T1 and T2, respectively) to detect the changes in the mitochondrial-apoptosis pathway-related molecules (FoxO1, BAD, BCL-XL, BCL-2, and BAX). At the same tim TGF-β2, Fluorosis, Mitochondrial Apoptosis, Osteoblasts, Signaling pathway https://www.ijper.org/boswellic-acid-loaded-nanoemulgel-for-rheumatoid-arthritis-formulation-design-an 2026-04-13T05:54:13.006716+00:00 Boswellic Acid Loaded Nanoemulgel for Rheumatoid Arthritis: Formulation Design and Optimization by QbD, in vitro, ex vivo, and in vivo Evaluation 2024-02-15 10.5530/ijper.58.2.61 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-546.pdf Background: Topical delivery of medication is often considered to be the best choice due to benefits such as avoidance of gastric degradation, first pass metabolism along with effortless application and retrieval. In topical delivery, the types of the vehicles and the physicochemical characteristics of drug are the prime variables that control the drug release and the therapeutic efficacy. The main component of Boswellia, Boswellic Acid (BA), is assumed to be accountable for the majority of phar Boswellic acid, Nanoemulgel, Anti-inflammatory effect, Rheumatoid arthritis, Topical, delivery https://www.ijper.org/assessment-of-factors-associated-with-generalized-anxiety-disorder-and-psycholog 2026-04-13T05:54:13.006716+00:00 Assessment of Factors Associated with Generalized Anxiety Disorder and Psychological Distress amid COVID-19 Pandemic: Cross-Sectional Study on the Students of Ras Al Khaimah Medical and Health Sciences University 2024-02-15 10.5530/ijper.58.2.74 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-661.pdf Background: Worldwide, the COVID-19 pandemic has caused higher levels of anxiety and psychological distress among university students. To effectively implement interventions in the UAE setting, it is crucial to have an awareness of the factors affecting the mental health of students. In the present study, we evaluated the prevalence of anxiety and psychological distress and the associated factors among medical and health sciences university students amid the COVID-19 outbreak. Materials and Meth COVID-19, Generalized anxiety disorder, Kessler psychological distress, Prevalence, Factors, United Arab Emirates https://www.ijper.org/exploring-analytical-quality-by-design-aqbd-enabled-rp-hplc-method-for-carvedilo 2026-04-13T05:54:13.006716+00:00 Exploring Analytical Quality by Design (AQbD) Enabled RP-HPLC Method for Carvedilol 2024-02-15 10.5530/ijper.58.2.73 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-651.pdf Background: Carvedilol (CDL) is a beta-blocker that helps to lower the risk of heart attack related mortality and is used to treat congestive heart failure and excessive blood pressure. Objectives: The present study deals with the development and validation of a reverse-phase high performance liquid chromatography method for rapid and reliable analysis of CDL by utilizing the Analytical Quality by Design (AQbD) approach. Materials and Methods: Critical Analytical Attributes (CAAs) were selected Analytical Quality by Design, Carvedilol, RP-HPLC, Box-Behnken design, Taguchi, Design https://www.ijper.org/ameliorative-effect-of-cichoric-acid-against-diabetes-associated-cognitive-decli 2026-04-13T05:54:13.006716+00:00 Ameliorative Effect of Cichoric Acid against Diabetes Associated Cognitive Decline with Emphasis on Neurobehavioral Activity, Aβ and AChE 2024-02-15 10.5530/ijper.58.2.66 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-595.pdf Background: Diabetes Mellitus (DM) is closely related to degenerative and functional abnormalities of the CNS. Studies indicate that an alteration in the CNS brought on by persistent hyperglycemia is primarily responsible for diabetes-related cognitive impairment proving a clear connection between DM and cognitive impairment. Anti-oxidants, antihyperglycemics, and insulin-sensitizing substances can lessen this diabetes-related cognitive impairment. Due to the anti-diabetic and antioxidant charac Diabetes mellitus, Cognitive dysfunction, Cichoric acid, Oxidative stress, Beta amyloid, Acetylcholinesterase https://www.ijper.org/demystifying-the-intricacies-of-research-methodology-scientific-publishing-and-p 2026-04-13T10:26:23.583377+00:00 Demystifying the Intricacies of Research Methodology, Scientific Publishing and Patenting 2024-02-15 10.5530/ijper.58.2.42 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-370.pdf It was generally believed that the most significant part of academic faculties’ work was teaching students, thus they devoted their all-time to the teaching-learning process. The basic requirements to become a faculty are more stringent now. At every stage of the academic profession, conducting prospective research and writing publications are regarded as essential tasks for a teaching faculty. One's scientific career can progress with a substantial body of research that is published. On 18 Dece Editorial https://www.ijper.org/assessment-of-dolichandrone-falcata-seem-leaves-for-anti-cancer-potential-in-exp 2026-04-13T05:54:13.006716+00:00 Assessment of Dolichandrone falcata Seem. Leaves for Anti-cancer Potential in Experimental Animal Models 2024-02-15 10.5530/ijper.58.2.58 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-519.pdf Background: Mammary cancer is the most common type of cancer and the leading cause of cancer-related death in women. Despite of numerous therapeutic options, cancer remains associated with high mortality. Traditional herb medicine has been found effective with minimal or no side effects. Materials and Methods: The leaves of Dolichandrone falcata Seem. (Bignoniaceae family) contains chrysin-7-rutinoside, flavanoids which possess Anti-cancer potential. The extract obtained from Soxhlet extraction Dolichandrone falcata, Anti-cancer, Flavonoids, Chemical carcinogen, Rats https://www.ijper.org/graphene-based-films-as-effective-mosquito-repellent-for-human-skin-protection-a 2026-04-13T05:54:13.006716+00:00 Graphene-Based Films as Effective Mosquito Repellent for Human Skin Protection: A Brief Review 2024-02-15 10.5530/ijper.58.2.43 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-377.pdf Mosquito-borne diseases pose significant public health threats worldwide, necessitating effective prevention strategies. Traditional chemical agents used for mosquito bite prevention often carry environmental and health risks. In this review, we explore the potential of graphene-based films as a non-chemical approach for protecting against mosquito bites. The aim of this review is to assess the effectiveness of multilayer graphene films in preventing mosquito bites and to explore their practical Graphene, Mosquito repellent, Chemo-sensing, Molecular barrier, Puncture, resistant’ s https://www.ijper.org/isolation-and-analysis-of-phanera-variegata-mucilage-by-various-analytical-techn 2026-04-13T05:54:13.006716+00:00 Isolation and Analysis of Phanera variegata Mucilage by Various Analytical Techniques 2024-02-15 10.5530/ijper.58.2.72 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-642.pdf Objectives: The objective of the present study was to isolate mucilage from the leaves of Phanera variegata L., to do the thermal, microscopic, elemental analysis, and physicochemical characterization of isolated mucilage. The various analytical methods were applied to mucilage and evaluated its nature, thermal stability, and structure. Materials and Methods: The mucilage was isolated and analyzed by various analytical methods like SEM, PXRD, particle size analysis, DSC, TGA, elemental analysis Phanera variegata, Pharmaceutical excipients, Mucilage, Microscopic analysis, Elemental analysis, Structure analysis https://www.ijper.org/partially-purified-polysaccharides-from-lentinus-edodes-mushroom-scavenge-free-r 2026-04-13T05:54:13.006716+00:00 Partially Purified Polysaccharides from Lentinus edodes (Mushroom) Scavenge Free Radicals and Induce Apoptosis in MCF-7 Cancer Cells by Regulating Apoptotic Genes 2024-02-15 10.5530/ijper.58.2.60 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-535.pdf Background: Therapeutic products obtained from nature have been gaining attention for health improvement, disease treatment, and drug development. Traditional therapeutic compounds from plants, animals, and microorganisms and their bioactive constituents have led to the development of therapeutics for various diseases, including cancer. Mushrooms are widely consumed products because of their nutritional and therapeutic potential. Materials and Methods: This study aimed to extract partially purif Mushrooms, Nutraceuticals, Breast Cancer, Apoptosis, Antioxidants https://www.ijper.org/emotional-intelligence-and-perceived-stress-in-pharmacists-completing-post-gradu 2026-04-13T05:54:13.006716+00:00 Emotional Intelligence and Perceived Stress in Pharmacists Completing Post-Graduate Specialization Programs: A Cross-Sectional Study 2024-02-15 10.5530/ijper.58.2.75 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-671.pdf Background: Emotional Intelligence (EI) has been recognized by the International Pharmaceutical Federation as a required competency for a pharmacist. This study aimed to compare EI and Perceived Stress (PS) levels in pharmacists who completed the post-graduate specialization program (the Case), and pharmacists who started the program (the Control group). Materials and Methods: Validated instruments measuring EI and PS were distributed online to participating postgraduates or alumni. All complete Emotional Intelligence, Perceived Stress, Pharmacy, Education, Specialization https://www.ijper.org/design-synthesis-anticancer-activities-and-comparative-molecular-docking-studies 2026-04-13T05:54:13.006716+00:00 Design, Synthesis, Anticancer Activities and Comparative Molecular Docking Studies of a Novel Class of 7-Azaindole Analogs as Potent PARP-1 Inhibitors 2024-02-15 10.5530/ijper.58.2.70 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-624.pdf Background: In a research facility, 7-azaindole derivatives were designed and synthesized, and each substance was examined for its capacity to inhibit cancer growth. In the present study, the synthesized analogues were docked with PARP enzyme to find a suitable site for PARP inhibition. Materials and Methods: 1H nuclear magnetic resonance, 13C NMR, and mass spectrometry were used to characterize all synthesized analogues of 7-azindole. On the MCF-7 cell line for breast cancer, their anticancer a 7-azaindole, Synthesis, Docking, Anticancer activity, PARP inhibitor https://www.ijper.org/reactive-astrogliosis-and-neuronal-functions-of-astrocytes-in-neurological-disor 2026-04-13T05:54:13.006716+00:00 Reactive Astrogliosis and Neuronal Functions of Astrocytes in Neurological Disorders 2024-02-15 10.5530/ijper.58.2.44 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-386.pdf Astrocytes are the most abundant cells in the brain. Astrocytes take part in the absorption and recycling of neurotransmitters, inflammation, neuroenergetics, the release of gliotransmitters, the regulation of synaptic activity, the maintenance of the blood-brain barrier, and other processes. Astrocytes help to keep the central nervous system healthy and functioning properly. These cells are linked to the onset and progression of various neurodegenerative diseases. Recent research has revealed t Astrocytes, Alzheimer’s disease, Multiple sclerosis, Neurodegeneration, Parkinson’s, disease https://www.ijper.org/investigation-on-the-phytochemistry-antioxidant-and-hepatoprotective-properties 2026-04-13T05:54:13.006716+00:00 Investigation on the Phytochemistry, Antioxidant, and Hepatoprotective Properties of the Ethanolic Extract of Gymnostachyum febrifugum Benth 2024-02-15 10.5530/ijper.58.2.55 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-496.pdf Background: The phytochemical evaluation of the ethanolic extract of the plant, Gymnostachyum febrifugum Benth. (Acanthaceae family) was carried out to evaluate its therapeutic potential. Despite being part of traditional medicine, not much research has been done on the plant. Materials and Methods: The study aimed to understand the plant’s phytochemistry and evaluate its therapeutic potential. For this purpose, DPPH, ABTS, FRAP, Total Antioxidant Assay, MTT Assay, and HR-LCMS techniques were em Gymnostachyum febrifugum Benth, Acanthaceae, Antioxidant assay, HR-LC MS, MTT, assay, hepatoprotective https://www.ijper.org/study-of-interactions-between-monoherbal-formulation-of-arjuna-and-aloe-vera-in 2026-04-13T05:54:13.006716+00:00 Study of Interactions between Monoherbal Formulation of Arjuna and Aloe vera in Isoproterenol Induced Cardiotoxicity Rat Model 2024-02-15 10.5530/ijper.58.2.53 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-480.pdf Introduction: Arjuna is used for its cardioprotective action while Aloe vera is herbal dietary supplement. Isoproterenol hydrochloride was administered subcutaneously to rats to induce myocardial infarction. Objectives: The given study was conducted to determine any pharmacodynamic interaction between marketed formulations i.e., Arjuna and Aloe vera. Materials and Methods: The varying tissue damage caused by Isoproterenol in different groups was confirmed from electrocardiogram (Heart rate, ST s Isoproterenol, Aloe vera, Arjuna, Myocardial infarction, Cardiotoxicity https://www.ijper.org/influence-of-cirsimaritin-on-anticancer-activity-against-hct-116-cell-line 2026-04-13T05:54:13.006716+00:00 Influence of Cirsimaritin on Anticancer Activity against HCT-116 Cell Line 2024-02-15 10.5530/ijper.58.2.67 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-603.pdf Background: Statistics show colon cancer is the third most severe cancer type worldwide. It was discovered that there is a very high death and morbidity rate. Along with breast, prostate, lung, and colon cancer is one of the most common tumors worldwide. Objectives: Natural products have drawn interest in recent years for preventing cancer. This is due to their numerous health advantages, apparent lack of toxicity and side effects, and the limits of chemotherapeutic medicines. Numerous studies h Colon cancer, Cirsimaritin, Apoptosis, Cell viability, ROS https://www.ijper.org/exploring-the-potential-of-plumbagin-as-an-activator-of-caspase-3-for-non-small 2026-04-13T05:54:13.006716+00:00 Exploring the Potential of Plumbagin as an Activator of Caspase 3 for Non-small Cell Lung Carcinoma: A Comprehensive in silico Study 2024-02-15 10.5530/ijper.58.2.59 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-526.pdf Caspase-3 regulates apoptosis, and its deregulation in Non-Small Cell-Lung Carcinoma (NSCLC), and contributes to tumour growth and therapeutic resistance. Significant resistance to chemotherapy and radiation therapy, which are two frequently used treatment modalities for lung cancer, is linked to the decreased activity of caspase-3 in NSCLC. Preclinical and early clinical investigations, for example, have shown potential for targeting specific biochemical pathways involved in caspase-3 regulatio Non-Small Cell-Lung Cancer (NSCLC), Caspase-3, Plumbagin, BOILED EGG Plot, analysis, ADMET/Tox, Molecular docking, MD simulation https://www.ijper.org/formulation-and-optimization-of-aripiprazole-loaded-nanostructured-lipid-carrier 2026-04-13T05:54:13.006716+00:00 Formulation and Optimization of Aripiprazole-Loaded Nanostructured Lipid Carriers for Nose-to-Brain Delivery 2024-02-15 10.5530/ijper.58.2.64 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-579.pdf Background: Low bioavailability, highly variable blood levels and poor clinical efficacy of Aripiprazole (ARP) are primarily linked to its hydrophobic nature. This investigation focused on the formulation of ARP loaded Nanostructured Lipid Carriers (NLCs) incorporated in thermoreversible in situ intranasal gel for brain delivery. Materials and Methods: The high-speed homogenization method was used to formulate ARP loaded NLCs. A factorial design was utilized to optimize the particle size, entrap Schizophrenia, Aripiprazole, Optimization, Poloxamer, Thermoreversible gel, Intranasal https://www.ijper.org/in-vitro-and-in-silico-investigations-on-the-anti-cancer-efficacy-of-eupatorin-a 2026-04-13T05:54:13.006716+00:00 In vitro and in silico Investigations on the Anti-cancer Efficacy of Eupatorin, a Polymethoxy Flavone against Ovarian Cancer PA-1 Cell Line 2024-02-15 10.5530/ijper.58.2.68 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-610.pdf Background: Ovarian cancer is a prominent contributor to cancer-related death among women residing in developed countries. The most of instances are discovered when the cancer has already developed, which results in dismal consequences. Surgery, chemotherapy, and radiation were the top priorities for first-line treatment in clinics. Traditional cancer treatments have a substantial risk of toxicity and cancer recurrence in females. Plant extracts can be utilized as an alternative to traditional c Eupatorin, Ovarian cancer, Apoptosis, PA-1 cells https://www.ijper.org/novel-deformable-vesicle-for-the-transdermal-delivery-of-terbinafine-hydrochlori 2026-04-13T05:54:13.006716+00:00 Novel Deformable Vesicle for the Transdermal Delivery of Terbinafine Hydrochloride-Formulation and Cytotoxic Evaluation 2024-02-15 10.5530/ijper.58.2.52 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-460.pdf Aim/Background: According to estimates, about a billion people in the world have fungal infections of the skin, nails, and hair. Skin disorders are a significant contributor to disability, deformity, and misery among people. In the present study, a versatile vesicular delivery of terbinafine hydrochloride through the dermal route in a biocompatible platform consisting of glycerine, phospholipids, and cholesterol is proposed for the treatment of mycoses. Materials and Methods: The glycerosomes of Glycerosomes, Terbinafine hydrochloride, Transdermal delivery, Skin permeation, Cytotoxicity https://www.ijper.org/evaluation-of-anti-proliferative-and-antioxidant-potency-of-ficus-benghalensis-h 2026-04-13T05:54:13.006716+00:00 Evaluation of Anti-proliferative and Antioxidant Potency of Ficus benghalensis Hydroalcoholic Bark Extract against Lung Cancer Cell Line-A549 2024-02-15 10.5530/ijper.58.2.57 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-2-510.pdf Background and Aim: One of the most prevalent cancers worldwide is lung cancer with the second top fatality rate. The purpose of this work is to disclose the anti-proliferative ability of hydroalcoholic Ficus benghalensis bark extract against lung cancer cell line (A549). Materials and Methods: Antioxidant property of Ficus benghalensis bark extract was studied using α, α-diphenyl-β-picrylhydrazyl and Hydrogen Peroxide assays. The investigation of anti-proliferative property of Ficus benghalensi Ficus benghalensis bark extract, Lung cancer cell line, Anti proliferation, Apoptosis, Oxidative stress, Anti-oxidant https://www.ijper.org/role-of-social-media-for-drug-safety-signal-detection 2026-04-13T05:54:14.187571+00:00 Role of Social Media for Drug Safety Signal Detection 2024-01-12 10.5530/ijper.58.1s.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-009.pdf Drug safety is an important factor considered during the drug discovery and development stages to develop safe and efficacious medicines for patients. Post-marketing surveillance is the commonly used method to obtain Adverse Drug Reaction (ADR) data of a marketed product through spontaneous reporting. In recent years, drug side effects are a major concern related to public health, increasing hospitalization and mortality rates. Social media has gained popularity in communicating and sharing ever Pharmacovigilance, Adverse Drug Reactions, Drug Safety, Signal Detection, Social, Media https://www.ijper.org/self-nanomicellar-dispersion-of-rosuvastatin-for-improved-bioavailability-formul 2026-04-13T05:54:14.187571+00:00 Self-Nanomicellar Dispersion of Rosuvastatin for Improved Bioavailability: Formulation, Optimization and Pharmacokinetic Studies 2024-01-12 10.5530/ijper.58.1s.19 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-196.pdf Introduction: Rosuvastatin is a statin drug used to lower cholesterol, but it has poor water solubility and low bioavailability, limiting how effective it can be. The objective of the present study was to formulate and evaluate a SNEDDS “self-nano emulsifying drug delivery systems” of Rosuvastatin and to optimize its formulation. Materials and Methods: The SNEDDS was produced using Egg lecithin, Capmul MCM, and Tween 20 as co-surfactant, oil, and surfactant, respectively. The formulation was opt Rosuvastatin, SNEDDS, Statistical optimization, Solubility, Dissolution rate, Bioavailability https://www.ijper.org/IndJPhaEdRes-58-1s-187 2026-04-28T07:36:26.908436+00:00 Formulation, Development and Characterization of PLGA-Luliconazole Nanoparticles Loaded Gel System for Topical Fungal Treatment 2024-01-12 10.5530/ijper.58.1s.18 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-187.pdf Background: Fungal infections are the primary cause of skin diseases. Topical application of antifungal drugs is the most preferred treatment which is associated with key limitations viz. need for high doses and frequency of application. By considering the limitations of current topical treatment, the present study involves the formulation and characterization of luliconazole nanogel. Materials and Methods: The luliconazole nanoparticles were prepared by using biodegradable polymer PLGA 50:50 an Nanoparticles, Nano-gel, Optimization, Antifungal, Skin test https://www.ijper.org/ethanolic-leaf-extract-of-centella-asiatica-l-possesses-nephroprotection-in-an-a 2026-04-13T05:54:14.187571+00:00 Ethanolic Leaf Extract of Centella asiatica L. Possesses Nephroprotection in an Animal Model of Nephrotoxicity 2024-01-12 10.5530/ijper.58.1s.29 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-274.pdf Background: Nephrotoxicity is a significant adverse effect of gentamicin, which is thought to be related to reactive oxygen species in the kidney. The purpose of this study was to look at how gentamicin-induced nephrotoxicity in rats was affected by a leaf extract from Centella asiatica L. Materials and Methods: Adult Wistar rats were divided into following groups: normal saline, gentamicin group injected with gentamicin sulfate (100 mg/kg, i.p) for 8 days, Centella asiatica L. groups administer Nephroprotective activity, Centella asiatica, Gentamicin, Nephrotoxicity https://www.ijper.org/quinazolin-4-one-derivatives-enoyl-acyl-carrier-protein-acp-reductase-inha-antag 2026-04-13T05:54:14.187571+00:00 Quinazolin-4-one Derivatives: Enoyl-acyl Carrier Protein (ACP) Reductase (InhA) Antagonists Using in silico Drug Design Approach 2024-01-12 10.5530/ijper.58.1s.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-093.pdf Aim: The configuration found programmed recreation ligand-receptor relations were worn during rework also rationale of investigate in order to establish budding bio-energetic candidate seeing that (Enoyl-ACP)-Enoyl-acyl carrier protein reductase (InhA) antagonist with in silico analog intend advance. Materials and Methods: InhA go towards NADH-dependent Enoyl ACP (Co-A) reductase enzyme folks also extend acyl fatty acid, which be progenitor of mycolic acid also myco-bacterial cells component. Qu Quinazolin-4-one, Anti-tubercular, InhA, Binding affinity, ADMET Study, 4TZK https://www.ijper.org/development-and-validation-of-stability-indicating-hplc-method-for-estimation-of 2026-04-13T05:54:14.187571+00:00 Development and Validation of Stability-indicating HPLC Method for Estimation of Azilsartan in Pharmaceutical and Solid Lipid Nanoparticles 2024-01-12 10.5530/ijper.58.1s.24 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-232.pdf Introduction: Azilsartan has been scientifically proven to be effective in treating hypertension. According to International Conference on Harmonization, the HPLC method was developed and validated to estimate the azilsartan in formulated solid lipid nanoparticles and marketed pharmaceutical formulations. Objectives: Develop and validate an HPLC method for analysing azilsartan in drugs and various formulations that demonstrated stability by ICH (International Conference on Harmonization) standar Azilsartan, Solid Lipid Nanoparticle, HPLC, Method Development, Degradation Study https://www.ijper.org/IndJPhaEdRes-58-1s-206 2026-04-28T07:36:55.239461+00:00 Regulatory Gap Analysis and Challenges in the Development of a Novel Candidate Vaccine in India 2024-01-12 10.5530/ijper.58.1s.20 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-206.pdf Background: The vaccine is a means to control and eradicate infectious diseases and also to strengthen health systems. There should be a complete ecosystem in a well-defined, transparent, and predictable regulatory system for the development of novel candidate vaccines. There is no specified regulatory pathway provided under the law for the approval of the novel candidate vaccine in the country leading to delays or long developmental timelines. Materials and Methods: A survey was conducted among Novel Candidate Vaccine, Rolling review, Emergency Use authorization (EUA), National Regulatory Authority (NRA), Central Drugs Standard Control Organization (CDSCO) https://www.ijper.org/fabrication-characterization-and-in-vitro-evaluation-of-atenolol-loaded-microspo 2026-04-13T05:54:14.187571+00:00 Fabrication, Characterization, and in vitro Evaluation of Atenolol Loaded Microsponges for Ocular Delivery 2024-01-12 10.5530/ijper.58.1s.14 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-149.pdf Aim: The purpose of the study was development and evaluation of Atenolol loaded microsponge in situ gel for the management of ocular hypertension, glaucoma. Materials and Methods: The microsponges were prepared by modified oil in oil emulsion solvent diffusion method. The polymers used for fabrication of microsponges include Ethyl Cellulose and Eudtagit RL-100. Results: The results of particle reveals that the particle size varies from 7.33 to 9.76μm, percentage yield ranges from 59.98 to 81.22, Microsponge, Atenolol, Ethyl Cellulose, Eudragit RL-100, in situ gel, Glaucoma https://www.ijper.org/in-vitro-and-in-vivo-wound-healing-potential-of-plant-commiphora-caudata 2026-04-13T05:54:14.187571+00:00 In vitro and in vivo Wound Healing Potential of Plant Commiphora caudata 2024-01-12 10.5530/ijper.58.1s.28 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-262.pdf Background: Commiphora caudata is commonly called hill mango, an incredibly available species of Commiphora, and belongs to Burseraceae. Commiphora caudata is commonly used in Ayurveda and Siddha medicines. Different parts of the plant have many pharmacological activities like antiviral, antispasmodic, cytotoxic, hypothermic activity, antiacne, hepatoprotective, febrifuge, antibacterial, antioxidant, and anti-inflammatory activities. Materials and Methods: Extracts were prepared by successive so Commiphora caudata, MTT, Scratch assay, IL-6, Excision, Diabetic model https://www.ijper.org/heterocyclic-compounds-and-their-derivatives-with-potential-anticancer-activity 2026-04-28T07:31:02.288271+00:00 Heterocyclic Compounds and their Derivatives with Potential Anticancer Activity 2024-01-12 10.5530/ijper.58.1s.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-026.pdf Cancer is the second leading cause of the death worldwide. As per the reports published by WHO, the cases of cancer in the world will increase to 22 million by 2030. Many resources are investigated all around the world for developing preventive, diagnostic and therapeutic strategies for cancer. Malignant cells display metabolic changes because of genetic and epigenetic alterations as compared to normal cell. Heterocycles are the key structural feature of many anti-cancer drugs present in the mar Heterocyclic compounds, Anticancer activity, Cell lines, Cytotoxicity, Natural product, FDA https://www.ijper.org/synthesis-characterization-in-silico-and-in-vivo-evaluation-of-amino-acid-derive 2026-04-13T05:54:14.187571+00:00 Synthesis, Characterization, in silico and in vivo Evaluation of Amino Acid Derived Schiff Bases of Quinoline- Benzimidazole Hybrids as Anti-epileptic Agents 2024-01-12 10.5530/ijper.58.1s.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-080.pdf Aim/Background: Novel quinoline compounds containing benzimidazole have been synthesized in a number of different ways and screened for anti-epileptic potential through in vivo and in silico studies. Materials and Methods: The novel quinoline-benzimidazole hybrids were synthesized by using substituted carbaldehyde (1,2) and substituted benzimidazole (derived from amino acids) (3a-f ). The synthesized derivatives were characterized by IR, 13C-NMR, 1H-NMR, and Mass spectroscopy and anti-convulsant Seizure, Anti-epileptic, Quinoline, Benzimidazole, Subcutaneous pentylenetetrazol https://www.ijper.org/high-performance-liquid-chromatography-method-development-and-validation-for-est 2026-04-13T05:54:14.187571+00:00 High-Performance Liquid Chromatography Method Development and Validation for Estimation of Mahanimbine in Curry Leaves 2024-01-12 10.5530/ijper.58.1s.22 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-217.pdf Aim: A designed, improved, and validated isocratic High Performance Liquid Chromatography method was used to study mahanimbine. Background: The method is evaluated for linearity, range, system applicability, LOD, LOQ, accuracy, and precision. Materials and Methods: For chromatographic separation, an Agilent ZORBAX Bonus RP C18 (250x4.6 mm, 5μ) column is employed. The mobile phase contains Methanol: 0.1 % Triethylamine (93:07%). The flow rate is 1.2 ml /min. The method is used to estimate Mahanim Mahanimbine; HPLC method development; Forced degradation studies; Extraction, of curry leaves https://www.ijper.org/design-formulation-and-in-vitro-evaluation-of-gastroretentive-microspheres-of-se 2026-04-13T05:54:14.187571+00:00 Design Formulation and in vitro Evaluation of Gastroretentive Microspheres of Selegiline Hydrochloride for Parkinson’s Disease by Design Expert 2024-01-12 10.5530/ijper.58.1s.31 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-289.pdf Introduction: Selegiline hydrochloride is primarily used to treat Parkinson’s disease. Selegiline hydrochloride mucoadhesive microspheres were prepared to improve the bioavailability of the drug and its appropriate therapeutic performance. Materials and Methods: The ionic gelation process was used to formulate the gastroretentive mucoadhesive microspheres using different polymers such as gum kondagogu (150 to 450 mg), karaya gum (10 to 70 mg), and carbopol 940P (150 to 450 mg) of different conce Selegiline hydrochloride, Parkinson’s disease, Mucoadhesion, Microspheres, Ionic, gelation method, Design Expert 13, Response Surface Methodology https://www.ijper.org/application-of-novel-natural-sweetening-agent-stevia-in-formulation-evaluation-o 2026-04-28T07:35:59.812816+00:00 Application of Novel Natural Sweetening Agent-Stevia in Formulation, Evaluation of Nicardipine Hydrochloride Orodispersable Tablets for Rapid Absorption 2024-01-12 10.5530/ijper.58.1s.17 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-176.pdf Objectives: The objective of this study was to develop a stable and effective form of an Orodispersible tablet containing Nicardipine Hydrochloride for the immediate treatment of high blood pressure and angina. The aim was to achieve this by using the natural sweetener stevia to improve taste. Background: Nicardipine Hydrochloride is used to treat high blood pressure and angina. However, currently available immediate release forms have limitations in terms of drug release and taste. Therefore, t Orodispersable tablets, Stevia rebaudiana FTIR, UV spectrophotometry, Angina, pectoris https://www.ijper.org/investigation-of-memory-enhancing-activity-of-combination-extracts-of-bauhinia-v 2026-04-13T05:54:14.187571+00:00 Investigation of Memory Enhancing Activity of Combination Extracts of Bauhinia variegata and Madhuca longifolia Leaves against Colchicine: An Experimental Study and Biochemical Alterations in Mice 2024-01-12 10.5530/ijper.58.1s.30 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-282.pdf Objectives: To investigate the role of combination of Madhuca longifolia (ML) and Bauhinia variegata (BV) ethanolic leaf extracts against oxidative damage in Swiss Albino mice and colchicine induced cognitive dysfunction; to estimate the neuroprotective impact using Madhuca longifolia and Bauhinia variegata combination by behavioral testing and to analyze the biochemical parameters. Materials and Methods: The experimental analysis was done for 28 days on a colchicine-induced model. Acute oral to Madhuca longifolia, Neuroprotective, Alzheimer’s disease, Bauhinia variegata, Colchicine, Acetylcholinesterase, Cognition https://www.ijper.org/evaluation-of-prescriptions-among-geriatric-patients-using-beers-criteria-in-a-t 2026-04-13T05:54:14.187571+00:00 Evaluation of Prescriptions among Geriatric Patients Using Beer’s Criteria in a Tertiary Care Setting 2024-01-12 10.5530/ijper.58.1s.26 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-245.pdf Introduction: The geriatric population is prone to physiologic changes, thus increasing the risk of medication-related problems. The use of potentially inappropriate medications is associated with profound medical and safety consequences in the elderly and imposes negative economic effects. Objectives: To assess drug therapy in geriatric patients using Beer's Criteria and analyze physician’s feedback in response to the suggestions provided. Materials and Methods: An observational, prospective st Beer’s Criteria, Geriatrics, Prevalence of Potentially inappropriate medications, Polypharmacy https://www.ijper.org/preparation-in-vitro-and-in-vivo-characteristics-of-floating-in-situ-gel-of-carv 2026-04-13T05:54:14.187571+00:00 Preparation, in vitro and in vivo Characteristics of Floating in situ Gel of Carvedilol Using Semi Synthetic and Natural Polymers to Enhance the Oral Bioavailability 2024-01-12 10.5530/ijper.58.1s.34 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-316.pdf Background/Aim: The purpose of this study was to design and prepare floating in situ gel to sustain Carvedilol (CVD) release and enhance oral bioavailability. Various floating in situ gel formulations of the CVD were prepared by ionic gelation method. Materials and Methods: A systematic approach in the design of the formulations was adopted, were using Hydroxypropyl Methyl Cellulose (HPMC K4M), Hydroxypropyl Methyl Cellulose (HPMC 100LV), Sodium alginate, Mimosa pudica seed mucilage and Limonia GRDDS, Mimosa pudica seed mucilage, Limonia acidissima gum, In situ gel, Carvedilol, HPMC K4M https://www.ijper.org/evaluation-of-the-anti-ulcer-activity-of-curcumin-and-linseed-oil-in-an-nsaid-in 2026-04-13T05:54:14.187571+00:00 Evaluation of the Anti-ulcer Activity of Curcumin and Linseed Oil in an NSAID-induced Gastric Ulcer Model in Rats 2024-01-12 10.5530/ijper.58.1s.27 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-252.pdf Background: Peptic Ulcer Disease is characterized by acid-induced ulcers in the stomach and duodenum. Their denuded mucosa with the distortion which extends into the submucosa or muscularis propria distinguishes them. The rationale behind this study was that long-term use of aspirin reduces Prostaglandins levels, due to which the protective mechanism of the gastric layer gets affected and results in sore formation and cytokine infiltration at the site of damage along with the inflammation. The s Peptic ulcer disease, Curcumin, Flaxseed oil, TNF-α, IL-1β https://www.ijper.org/synthesis-and-bioactive-investigation-of-amino-acids-fused-134-oxadiazole-deriva 2026-04-13T05:54:14.187571+00:00 Synthesis and Bioactive Investigation of Amino Acids Fused 1,3,4-Oxadiazole Derivatives as Unnatural Amino Acids 2024-01-12 10.5530/ijper.58.1s.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-067.pdf Background: In present study 1,3,4-oxadiazole was attempted to synthesize from nicotinic acid and further their amino acid derivates were formed. Amino acids play a significant role in biological system. Only 20 amino acids are naturally used, yet even little changes to these amino acids can produce an amazing diversity in terms of their chemical structure and function. Unnatural amino acids can be used to develop novel drugs, novel hormones, and novel enzymes. Materials and Methods: Derivatives 1, 3, 4-oxadiazole, Unnatural amino acids, Microwave synthesis, Scavenging activity, Amino acids, DPPH https://www.ijper.org/development-and-evaluation-of-self-micro-emulsifying-formulation-of-venlafaxine 2026-04-28T07:33:56.481539+00:00 Development and Evaluation of Self Micro-Emulsifying Formulation of Venlafaxine HCl with Improved Antidepressant Activity 2024-01-12 10.5530/ijper.58.1s.10 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-103.pdf Aim/Background: Venlafaxine HCl (VEN) is an antidepressant drug with extensive first pass metabolism and low oral bioavailability. In the present study, a solid self-emulsifying formulation of Venlafaxine was developed and evaluated for in vitro and in vivo performance. Materials and Methods: Various oils, surfactants, and cosurfactants were screened for the solubility of Venlafaxine in them. Surfactants were further screened based on their ability to emulsify oils. For the SMEDDS formulation, C Venlafaxine, Self-microemulsifying drug delivery system, Anti-depressant, First pass, effect, Bioavailability, Solubility https://www.ijper.org/association-and-prevalence-of-alcoholism-in-epileptic-patients-at-tertiary-care 2026-04-13T05:54:14.187571+00:00 Association and Prevalence of Alcoholism in Epileptic Patients at Tertiary Care Teaching Hospital 2024-01-12 10.5530/ijper.58.1s.25 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-241.pdf Background: The effects of alcohol are complexly interlinked with the pathophysiology of epilepsy. Given that both epilepsy and alcohol have a significant detrimental impact on the brain; it is essential to investigate alcohol's causative involvement as an independent risk factor for epilepsy. Thus, the study aimed to quantify alcohol as an etiologic factor of epilepsy and find its prevalence in the study population. Materials and Methods: A prospective cross-sectional study was conducted in the Alcohol, Epilepsy, New onset seizure, Prevalence, Alcohol-Related Seizure https://www.ijper.org/design-expert-implemented-nimodipine-loaded-lyophilized-nanoemulsifying-drug-del 2026-04-13T05:54:14.187571+00:00 Design Expert-Implemented Nimodipine-Loaded Lyophilized Nanoemulsifying Drug Delivery System for Improved Oral Bioavailability and Physical Stability 2024-01-12 10.5530/ijper.58.1s.12 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-126.pdf Purpose: To improve the oral bioavailability as well as the physical stability of nimodipine, Design-Expert-driven nimodipine loaded nanoemulsifying drug delivery system was developed with a certain quality target product profile. Materials and Methods: In this investigation, the three components triacetin as oil phase, labrasol as a surfactant, and plurol oleique CC 497 as co-surfactant were selected after screening. The ratio of surfactant and co-surfactant (Smix) was selected from the pseudo- Bioavailability, Physical stability, Pseudo ternary phase diagram, Design-Expert, Lyophilized, Nanoemulsifying drug delivery system https://www.ijper.org/evaluation-of-in-vitro-anti-cancer-activity-of-linum-usitatissimum-and-mentha-sp 2026-04-13T05:54:14.187571+00:00 Evaluation of in vitro Anti-cancer Activity of Linum usitatissimum and Mentha spicata Combination Extract against MCF7 Breast Cancer Cell-line 2024-01-12 10.5530/ijper.58.1s.21 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-212.pdf Background/Aim: Breast cancer is one of the most common cancers among women in India. Though the current treatment is beneficial, it is complicated with lots of risks and disadvantages. So, the search for alternatives especially phytochemicals is increasing recently. Linum usitatissimum (Flaxseed) and Mentha spicata (Spearmint) are plant-based products, which are known for their various health benefits, exhibited anticancer activities independently in vitro. With the Proven importance of drug sy Anti-cancer activity, Flaxseed, Spearmint, Breast cancer, MTT assay https://www.ijper.org/enhancement-of-solubility-of-albendazole-by-inclusion-complexation-with-nanospon 2026-04-13T05:54:14.187571+00:00 Enhancement of Solubility of Albendazole by Inclusion Complexation with Nanosponges and β-Cyclodextrin 2024-01-12 10.5530/ijper.58.1s.33 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-306.pdf Aim: Objective of work was to compare role of β-Cyclodextrin (β-CD) and Nanosponges (NS) prepared with different cross-linking ratios and different drug loading ratios to enhance solubility and dissolution rate of Albendazole (ALB). Materials and Methods: Diphenyl Carbonate (DPC) was used as cross-linker for preparing NS with various β-CD and DPC ratios (1:2 and 1:4). Solvent evaporation was used to make binary complex. ALB and NS were dissolved in Dichloromethane (DCM) in 1:1 and 1:2 ratios and β-cyclodextrin, Binary complex, Nanosponges, Albendazole https://www.ijper.org/chemical-and-pharmacological-assessment-of-substituted-124-triazole-fused-pyrimi 2026-04-13T05:54:14.187571+00:00 Chemical and Pharmacological Assessment of Substituted 1,2,4-Triazole Fused Pyrimidines as Anti-microbial Agent 2024-01-12 10.5530/ijper.58.1s.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-073.pdf Objectives: To synthesize a novel series of 3-(Aryl/Heteroaryl)-5-Methyl-7-Phenyl [1,2,4]triazolo[4,3a]Pyrimidines (5a-i). Materials and Methods: Synthesis was carried out though the microwave assisted synthesis, Spectroscopic approaches such as IR,1HNMR and MASS spectroscopy were used to characterize the produced substances. Antimicrobial screening was done by Cup Plate Method for the antibiotic zone determination and Minimum Inhibitory Concentration was determined by the tube dilution method. Triazolopyrimidines, Pyrimidinylhydrazones, Iodobenzene diacetate, Antibacterial, activity https://www.ijper.org/molecular-insights-into-salicylate-synthase-from-medicinal-chemistry-perspective 2026-04-13T05:54:14.187571+00:00 Molecular Insights into Salicylate Synthase: From Medicinal Chemistry Perspective 2024-01-12 10.5530/ijper.58.1s.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-058.pdf Tuberculosis is a pathogenic infection that has created trepidation around the globe due to its repercussion on the health of patients. The iron transport mechanism in mycobacterium plays a pivotal role in bacterial survival; whilst this can be considered an emerging drug target. Salicylate synthase is a member of the MST family and this enzyme is distrait in mammals. It is the first enzyme for the synthesis of mycobactin (siderophores) which is a determinant for iron transport. The present all- Mycobacterium tuberculosis, Anti-tubercular drug targets, Siderophores, Mycobactin, Salicylate synthase (MbtI) https://www.ijper.org/design-and-evaluation-of-different-transdermal-therapeutic-systems-of-promethazi 2026-04-13T05:54:14.187571+00:00 Design and Evaluation of Different Transdermal Therapeutic Systems of Promethazine Hydrochloride 2024-01-12 10.5530/ijper.58.1s.13 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-139.pdf Background: Promethazine Hydrochloride is a water-soluble drug and it suffers from poor bioavailability (25%) when given through oral route due to extensive first-pass metabolism. To overcome hepatic first pass metabolism and to enhance bioavailability, transdermal drug delivery systems (patches and gels) can be exploited. Objectives: The present work describes the transdermal permeation of anti-emetic agent promethazine hydrochloride and its transdermal delivery using transdermal patches and ge Enhancement ratio, Flux, Promethazine Hydrochloride, Permeation, Transdermal, patches, Transdermal gels https://www.ijper.org/floating-drug-delivery-of-sustained-release-anti-depressant-mirtazapine-tablets 2026-04-13T05:54:14.187571+00:00 Floating Drug Delivery of Sustained Release Anti-depressant Mirtazapine Tablets by Box-Behnken Design: Formulation and Optimization 2024-01-12 10.5530/ijper.58.1s.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-113.pdf Background: Mirtazapine widely prescribed Antidepressant drug that belongs to BCS Class II drug with low solubility and high permeability characteristics. Aim: The Box Behnken design was used to statistically optimize the formulation on the efficacy of gastroretentive floating tablets of mirtazapine. Materials and Methods: The 3 components of 3 levels of the design were used to examine the replies and create a polynomial model using design expert software. Three different independent factors wer Floating, Sustained release, Drug release, Mirtazapine, Mirtafresh 15-MD https://www.ijper.org/insight-into-the-regulation-of-nrf2keap-1-pathway-by-flavonoids-as-an-approach-f 2026-04-13T05:54:14.187571+00:00 Insight into the Regulation of Nrf2/Keap 1 Pathway by Flavonoids as an Approach for Treatment of Liver Diseases: A Review 2024-01-12 10.5530/ijper.58.1s.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-040.pdf Around 10% of the world’s population suffers from liver disease, making it one of the deadliest diseases in the world. Flavonoids are a class of phenolic substituents present in a wide range of vegetables and fruit and have been identified to control the Nrf2 pathway. Therefore, flavonoids are attracting significance as a therapeutic strategy for liver disease. The main objective of this review discuss the role of flavonoids modulate Nrf2 for the prevention and treatment of liver disease. It has Nrf2, Liver, Flavonoids, Antioxidant, Hepatic disease, Keap1 https://www.ijper.org/bio-analytical-method-development-for-pharmacokinetic-study-of-novel-lafutidine 2026-04-13T05:54:14.187571+00:00 Bio-analytical Method Development for Pharmacokinetic Study of Novel Lafutidine Formulation in Rabbit Plasma Using RP-HPLC 2024-01-12 10.5530/ijper.58.1s.23 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-224.pdf Objectives: The main objective of the study is to carry out comparative in vivo pharmacokinetic study of novel formulation with marketed formulation of lafutidine using HPLC method. Materials and Methods: The animals were selected according to the study protocol and divided in to three groups. The animals were given lafutidine marketed and novel formulation orally; at predetermined time blood samples were collected and subjected to the protein precipitation to collect blood plasma. The plasma sa In vivo study, Pharmacokinetic, Novel formulation, Rabbit plasma, HPLC https://www.ijper.org/quality-concerns-of-lip-care-cosmetics-and-applicable-regulatory-framework-need 2026-04-13T05:54:14.187571+00:00 Quality Concerns of Lip Care Cosmetics and Applicable Regulatory Framework: Need for a Harmonized Cosmetovigilance Programme 2024-01-12 10.5530/ijper.58.1s.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-001.pdf Cosmetics still have a glitzy attraction, but the public is increasingly concerned about their toxicity. Since 2500 BC, one way of enhancing the beauty of lips has been using lipstick compositions. Lip care cosmetic product usually contains emollients, waxes, texturing agents, preservatives, and oils. Women apply lipstick two to several times per day, according to the researchers. In terms of substance exposure, that translates as consuming or holding onto approximately 87 mg of lipstick every d Lipstick, Lip care, Adulterants, Regulations, Toxicity, Cosmetovigilance https://www.ijper.org/formulation-and-evaluation-of-floating-oral-in-situ-gel-of-liquorice-extract 2026-04-13T05:54:14.187571+00:00 Formulation and Evaluation of Floating Oral in situ Gel of Liquorice Extract 2024-01-12 10.5530/ijper.58.1s.16 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-167.pdf Background: The in situ gel, which after gelation floats in the stomach, is appropriate for sustaining drug release. Aqueous extract of liquorice used for the treatment of peptic ulcers and Helicobacter pylori, was used to create an in situ gel in the current research study for prolonged action. Materials and Methods: The aqueous extract of liquorice was subjected to phytochemical screening; pre-formulation studies such as extract compatibility with selected polymers. In situ gel containing liqu Liquorice extract, in situ gel, Peptic ulcer, Sustained release, Sodium Alginate, HPMC, K100M, Gelling capacity, Floating ability https://www.ijper.org/secondary-metabolites-and-antioxidants-activity-from-citronella-grass-extract-cy 2026-04-28T07:39:55.590197+00:00 Secondary Metabolites and Antioxidants Activity from Citronella Grass Extract (Cymbopogon nardus L.) 2024-01-12 10.5530/ijper.58.1s.32 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-298.pdf Background: Cymbopogon nardus L. is a rhizome plant that is widely used as traditional medicine. This research aimed to identify how the secondary metabolites of citronella grass including stems, leaves, and roots and other contents like the antioxidant and flavonoids compared to the ordinary citronella and reeds. Materials and Methods: GCMS (Gas Chromatography and Mass Spectroscopy) method was used to screen secondary metabolites along with methanol solvent. Then, the compounds could be identif Antioxidants, Cymbopogon nardus, Flavonoids, Secondary metabolites https://www.ijper.org/development-and-validation-of-a-bioanalytical-method-to-determine-empagliflozin 2026-04-13T05:54:14.187571+00:00 Development and Validation of a Bioanalytical Method to Determine Empagliflozin in Human Plasma Using UPLC-MS/MS 2024-01-12 10.5530/ijper.58.1s.35 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-325.pdf Aim: The study we are conducting aims to establish a validated method for measuring empagliflozin in plasma using UPLC MS/MS. Materials and Methods: Sodium-Glucose co Transporter inhibitors (SGLTi), a novel class of diabetes medication. Non-insulin dependent diabetes and adult-onset diabetes were the prior names for type 2 diabetes. Empagliflozin was the first SGLT2-inhibitor a drug used that reduced the risk of cardiovascular risk those with type 2 diabetes and pre-existing cardiovascular disea Type 2 diabetes (T2D), Empagliflozin, Human Plasma, UPLC-MS/MS, Type 2 diabetes (T2D), Empagliflozin, Human Plasma, UPLC-MS/MS https://www.ijper.org/amelioration-of-dissolution-properties-of-abiraterone-acetate-via-nano-sizing-em 2026-04-28T07:35:07.739696+00:00 Amelioration of Dissolution Properties of Abiraterone Acetate via Nano-Sizing Employing High-Speed Homogenization Technique: An Optimization Study 2024-01-12 10.5530/ijper.58.1s.15 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-58-1s-158.pdf Background: Abiraterone acetate is an anticancer molecule indicated for prostate cancer. The purpose of this study was to develop a nanosuspension of abiraterone acetate in order to improve its solubility, dissolution properties and bioavailability. Materials and Methods: High speed homogenization method was utilized to formulate the nanosuspension. Design of experiment (DoE) was employed for the optimization of process and formulation variables. Nanosuspension was evaluated for particle size, P Abiraterone acetate, Nanosuspension, Nanocrystals, Dissolution enhancement, Quality by Design https://www.ijper.org/evaluation-of-potentiality-of-salvia-hispanica-in-the-management-of-irritable-bo 2026-04-28T05:26:44.278094+00:00 Evaluation of Potentiality of Salvia hispanica in the Management of Irritable Bowel Syndrome in Wistar Albino Rats 2023-05-20 10.5530/ijper.57.2s.41 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-353.pdf Introduction: Globally, approximately 11% of the population has been affected by the irritable bowel syndrome. Recent advancement in medical area have made it easily possible to find out the proper pathophysiology behind the generation of symptoms of irritable bowel syndrome followed by its treatment. Objective: The aim of this research is to check the effect of mucilage of Salvia hispanica on gastrointestinal tract symptoms (IBS) as a result of excessive fibers availability in the mucilage. Mat IBS, Salvia hispanic mucilage, Water Avoidance Stress Model, Serotonin, Food Related Stress Model of IBS https://www.ijper.org/comparison-between-olive-oil-and-nano-bio-fusion-gel-and-their-role-in-the-treat 2026-04-28T05:21:39.174851+00:00 Comparison between Olive Oil and Nano-Bio Fusion Gel and their Role in the Treatment of Alveolar Osteitis: A Double-Blind Randomized Trial 2023-05-20 10.5530/ijper.57.2s.36 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-315.pdf Background: Alveolar osteitis is a painful condition that occurs after tooth extraction. This condition has been treated with various chemical and herbal formulations that are found to be efficacious with different success rates. Objectives: The present study is aimed to evaluate and compare the efficacy of organic olive oil and Nano-Bio Fusion (NBF) gel in the management of alveolar osteitis. Materials and Methods: 90 patients who were diagnosed with alveolar osteitis following non-surgical den Alveolar osteitis, Pain, Extraction, Mandibular third molars, Olive oil, Nano-Bio Fusion https://www.ijper.org/preparation-and-characterization-of-silver-nanoparticle-cross-linked-polymeric-c 2026-04-28T05:23:17.330323+00:00 Preparation and Characterization of Silver Nanoparticle Cross-linked Polymeric Cages by Freshwater Cyanobacteria and their Bactericidal Evaluation against Multi-Drug Resistant Bacteria 2023-05-20 10.5530/ijper.57.2s.38 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-327.pdf Introduction: Over the past 60 years, numerous modern types of antibiotics have been developed. Antibiotic overuse has been largely responsible for spreading resistant strains that endangering the public's health at an alarming rate. It prompted the pacing advert of new resistance mechanisms and a lessening in the productivity of treating common infectious. Objectives: The present study emphasizes using cyanobacteria silver nanoparticle conjugates (Ag-NPCs) as a drug delivery system to predomina Cyanobacteria, Multi-Drug Resistant bacteria, Cyanobacteria Silver nanoparticle conjugates, Drug delivery system, Antibacterial activity https://www.ijper.org/molecular-docking-and-in-vitro-enzyme-assay-of-bioactive-compound-isolated-from 2026-04-17T09:38:03.078012+00:00 Molecular Docking and in vitro Enzyme Assay of Bioactive Compound Isolated from Rhus tripartite Collected from Hail Region of Saudi Arabia as Potential Anti-Diabetic Agent 2023-05-20 10.5530/ijper.57.2s.52 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-442.pdf Aim: In the present investigation, we have studied the inhibitory potential of a bioactive compound isolated from Rhus tripartite on Glucokinase (GK), Dipeptidyl Peptidase-IV (DPP-IV), alpha-glucosidase, and alpha-amylase enzymes. Materials and Methods: The plant leaves were subjected to Soxhlet extraction followed by qualitative phytochemical screening and the separation of active constituents by applying column chromatography. The obtained fraction was subjected to spectral analysis to identif DPP-IV, in-vitro, Rhus tripartite, Isolation, Characterization https://www.ijper.org/design-and-development-of-oxyclozanide-chewable-tablet-formulation-employing-qua 2026-04-28T05:32:16.93011+00:00 Design and Development of Oxyclozanide Chewable Tablet Formulation Employing Quality by Design Approach 2023-05-20 10.5530/ijper.57.2s.51 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-434.pdf Background: The focus of this research was to identify undiscovered knowledge associated with the production of oxyclozanide tablets utilizing Quality by Design (QbD) in order to develop an ideal formulation that would guarantee constant product quality. The modern approach to formulation design and optimization essentially entails QbD which is a systemic method of pharmaceutical development and comprises of the design and development of formulations as well as manufacturing processes to meet th Quality by Design (QbD), Oxyclozanide, Chewable tablet, Compactibility, Tabletability https://www.ijper.org/binding-of-novobiocin-paves-the-way-for-inhibition-of-deah-box-helicase-8 2026-04-17T09:38:00.417421+00:00 Binding of Novobiocin Paves the Way for Inhibition of DEAH-box Helicase 8 2023-05-20 10.5530/ijper.57.2s.54 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-459.pdf Introduction: DEAH-box helicase 8 (DHX8) is a crucial DEAH-box RNA helicase involved in splicing and required for the release of mature mRNA from the splice. Here, we report the interaction study of human DHX8 and four test compounds namely etoposide, netropsin, nogalamycin, and novobiocin. Materials and Methods: Molecular docking and fluorescence emission spectra techniques were employed to determine the binding and inhibitory effect of test compounds. Results: Our docking and fluorescence emis DEAH-box helicase, DHX8, Novobiocin, Splicing, Therapeutics https://www.ijper.org/authentication-of-averrhoa-carambola-l-using-dna-barcoding-detection-of-snps-and 2026-04-28T05:25:55.32928+00:00 Authentication of Averrhoa carambola L. Using DNA Barcoding: Detection of SNPs and Evaluation of Phylogenetic Relationship 2023-05-20 10.5530/ijper.57.2s.39 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-335.pdf Background: Averrhoa carambola L. (star fruit) is an underutilized plant in the family Oxalidaceae. The plant has various pharmacological activities and has fleshy juicy fruit with high nutritional value and is rich in vitamins. Objectives: This study aims to authenticate and examine the evolutionary relationships between various Averrhoa taxa. Materials and Methods: The species identification was verified using the well-established DNA barcoding method. For this, a few predetermined loci includ Averrhoa carambola, DNA Barcoding, atpF–atpH, matK, rpoB https://www.ijper.org/formulation-and-characterization-sustained-release-mucoadhesive-microcapsule-of 2026-04-28T05:16:17.309762+00:00 Formulation and Characterization Sustained Release Mucoadhesive Microcapsule of Baclofen 2023-05-20 10.5530/ijper.57.2s.28 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-244.pdf Background: Baclofen is used as skeletal muscle relaxant. Baclofen inhibit Polysynaptic and monosynaptic reflexes a hyperpolarisation. Baclofen drug absorbed rapidly and excreted in feces urine in unchanged form. Objectives: Aim of the current study was to formulate sustained release mucoadhesive microcapsules of Baclofen using different polymers like Chitosan, Carbopol934P, HPMC K4M. Materials and Methods: Ionotropic gelation method was used for preparation of microcapsules of baclofen. Dispers Baclofen, Microcapsule, Carbopol 934P, HPMC K4M, Sustained Release https://www.ijper.org/management-of-anxiety-in-coronary-artery-bypass-grafting-patients-the-influence 2026-04-28T05:30:08.463728+00:00 Management of Anxiety in Coronary Artery Bypass Grafting Patients: The Influence of Chair Aerobics and Nadisodhana Pranayama-A Pilot Randomized Clinical Trial 2023-05-20 10.5530/ijper.57.2s.47 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-405.pdf Background: Anxiety is a primary concern affecting the prognosis of CABG patients. Relieving anxiety is thus a component of management in patients with CABG. We use two feasible and cost-effective treatment techniques to know the improvement in symptoms of anxiety. Objectives: To evaluate the efficacy of chair aerobics and pranayama on anxiety in patients who underwent CABG. We hypothesized that there would be an improvement in anxiety in CABG patients after receiving the interventions. Material Coronary Artery Bypass, Anxiety, Nadi-sodhana Pranayama, Chair aerobics, Cardiac rehabilitation https://www.ijper.org/in-vivo-performance-of-a-hydrogel-of-tribulus-terrestris-in-alloxan-induced-diab 2026-04-28T05:28:16.106587+00:00 In vivo Performance of a Hydrogel of Tribulus terrestris in Alloxan induced Diabetic Rats 2023-05-20 10.5530/ijper.57.2s.45 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-391.pdf Background: Diabetes is one of the most important factors in chronic injuries. The gold standard for treating diabetic foot ulcers includes debridement of wounds, management of all infections, revascularization when indicated, and non-loading of ulcers. Traditionally, the aerial parts of Tribulus terrestris L. (Zygophyllaceae) are used in the folklore for the treatment of various kinds of wounds. Materials and Methods: Based on the evaluation of phytochemicals, a hydrogel of the hydroalcoholic a Diabetes, Tribulus terrestris, Wound healing, Alloxan, Hydroxyproline, Hydrogel https://www.ijper.org/a-recent-review-on-synthesis-characterization-and-activities-of-gold-nanoparticl 2026-04-17T09:38:02.919009+00:00 A Recent Review on Synthesis, Characterization and Activities of Gold Nanoparticles Using Plant Extracts 2023-05-20 10.5530/ijper.57.2s.24 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-198.pdf Despite advances in synthetic medications, medicinal herbs have empowered mankind with a wide range of efficacious medicines to lessen or eliminate illnesses and suffering from diseases. Since the last decade there has been increasing enthusiasm for the synthesis of gold nanoparticles particularly from herbal extract because the method is a one pot process, environment friendly, safe, convenient and can be produced in large scale. Aqueous extract of several parts of herbs have been utilised, lik Plant extract, Gold nanoparticles, Synthesis, Characterization, Activity https://www.ijper.org/quality-by-design-driven-development-of-topical-gel-encompassing-papain-and-brom 2026-04-28T05:19:01.507126+00:00 Quality by Design Driven Development of Topical Gel Encompassing Papain and Bromelain to Elicit Wound Healing 2023-05-20 10.5530/ijper.57.2s.32 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-281.pdf Background: Topical gels are an efficient and targeted therapy for local dermatological problems because they distribute medications effectively and are easy to wipe off the skin. The presented study was aimed to use Quality by Design (QbD) features to develop, optimise, and evaluate a topical gel containing certain plant enzymes for wound healing activity. Objectives: The objective of this study was to use contour plots and multiple linear regression analysis to determine the relative relevance Quality by design, Plant enzyme, Factorial design, Wound, Topical gel, Spreadability https://www.ijper.org/enhanced-solubility-and-dissolution-of-drug-drug-cocrystals-of-lopinavir-ritonav 2026-04-28T05:19:35.1668+00:00 Enhanced Solubility and Dissolution of Drug-drug Cocrystals of Lopinavir-Ritonavir 2023-05-20 10.5530/ijper.57.2s.33 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-292.pdf Introduction: Drug-drug cocrystals of Lopinavir and Ritonavir were designed and characterized. In view of literature, Ritonavir increases the oral bioavailability of Lopinavir in low dosage. Aim: The present research aimed to improve the solubility, dissolution, and oral bioavailability of Lopinavir through a cocrystallization approach using Ritonavir as a coformer. Materials and Methods: Cocrystallization was carried out using wet grinding and solvent evaporation methods. Prepared Cocrystals we Lopinavir, Ritonavir, Multi-Drug Cocrystals, Solubility, Dissolution https://www.ijper.org/design-formulation-and-statistical-evaluation-of-gastroretentive-microspheres-of 2026-04-28T05:17:33.702445+00:00 Design Formulation and Statistical Evaluation of Gastroretentive Microspheres of Rasagiline Mesylate for Parkinson’s Disease Using Design Expert 2023-05-20 10.5530/ijper.57.2s.30 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-262.pdf Introduction: Rasagiline mesylate is primarily prescribed to treat the symptoms of idiopathic Parkinson's disease works as irreversible inhibitor of mono amino oxidase. The microspheres were designed for extended retention of drug in gastrointestinal tract, resulting in superior absorption and enhanced bioavailability by oral route. Materials and Methods: The ionotropic gelation method was used to prepare the formulations RM1 to RM14 mucoadhesive microspheres with Sodium alginate, Calcium chlori Rasagiline mesylate, Parkinson’s disease, Mucoadhesion, Microspheres, Design expert, Response surface methodology https://www.ijper.org/design-synthesis-and-biological-screening-of-novel-carbazole-tethered-oxyethylam 2026-04-17T09:38:00.091369+00:00 Design, Synthesis and Biological Screening of Novel Carbazole Tethered Oxyethylamino Derivatives as Antimicrobial Agent 2023-05-20 10.5530/ijper.57.2s.46 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-399.pdf Background: Carbazole is an important scaffold known to be associated with several biological activities including antimicrobial activities. Incorporation 4-oxothiazolidine moiety in carbazole moiety may lead to a new series of antimicrobials compounds. Aim: In this study, design and synthesis of novel carbazole tethered oxyethylamino was started with carbazole as basic pharmacophore and evaluated for antimicrobial activity. Materials and Methods: Molecular docking of carbazole derivatives was c Molecular Docking, Carbazole, Oxyethylamino, Antimicrobial activity, Antifungal activity https://www.ijper.org/development-of-pharmacognostic-profile-and-preliminary-phytochemical-study-of-pl 2026-04-17T09:38:00.73547+00:00 Development of Pharmacognostic Profile and Preliminary Phytochemical Study of Pluchea wallichiana DC 2023-05-20 10.5530/ijper.57.2s.50 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-424.pdf Introduction: The genus Pluchea comprises of around 80 species native to tropical and warm temperate areas. It has been traditionally known as rasna and used to treat different ailments including inflammation and arthritis. One of the species of Pluchea, Pluchea wallichiana DC (Family: Asteraceae), commonly known as wallich camphor weeds. Aim and Objectives: The present study aims to develop pharmacognostic profile, set the qualitative and quantitative characteristics of phytochemicals present i Pluchea wallichiana, Morphology, Microscopy, Flavonoids, HPTLC, Antioxidant activity, Mineral element https://www.ijper.org/mucoadhesive-films-of-liquorice-and-chlorhexidine-gluconate-for-treating-mouth-u 2026-04-28T05:18:12.286465+00:00 Mucoadhesive Films of Liquorice and Chlorhexidine Gluconate for Treating Mouth Ulcers 2023-05-20 10.5530/ijper.57.2s.31 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-274.pdf Objectives: Mouth ulcer is a rupture or breaks in the oral mucosal membrane and it leads to atrophy and ulcers in the oral cavity. It increases the risk of infections with the Candida species Inherited trauma and aphthous stomatitis, a disorder characterised by the recurrent production of oral ulcers for unknown reasons, are the most common causes of oral ulceration. Study Design: This study aimed to develop two separates buccal mucoadhesive films, using model drug deglycyrrhizinated liquorice a Deglycyrrhizinated liquorice, Chlorhexidine gluconate, Mucoadhesive buccal films, Anti-inflammatory activity https://www.ijper.org/toxicological-study-of-n-hexane-and-chloroform-extracts-of-lantana-camara-l-in-e 2026-04-17T09:37:59.561412+00:00 Toxicological Study of n-hexane and Chloroform Extracts of Lantana camara L. in Experimental Animals 2023-05-20 10.5530/ijper.57.2s.43 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-370.pdf Aim: The aim of the current study is to investigate the acute, sub-acute and sub-chronic toxicity study of extracts (n-hexane and chloroform) of L. camara in Wistar rats. Materials and Methods: HPTLC and GC-MS analysis were carried out to analyze different constituents present in L. camara extract. Acute toxicity study was conducted as per OECD 420 guidelines, while sub-acute and sub-chronic studies were conducted according to OECD 407 and 408 guidelines respectively. Toxicopathological effects Lantana camara, GC-MS, HPTLC, Toxicity, Histopathology, Antioxidant, PI uptake https://www.ijper.org/finding-the-principle-leads-using-gc-ms-and-unravelling-the-anti-inflammatory-ac 2026-04-28T05:26:20.752846+00:00 Finding the Principle Leads using GC-MS and Unravelling the Anti-inflammatory Activity of Alkaloid Isolated from Caesalpinia bonducella by in vitro Techniques 2023-05-20 10.5530/ijper.57.2s.40 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-345.pdf Aim/Background: Plant-based medicines have gained remarkable recognition recently, as consumers have begun to express their preference for herbal remedies. C. bonducella, commonly known as fever nut, is said to have massive value in Ayurveda regarding health and cosmetics. We aim to envisage the alkaloid for its anti-inflammatory property using in-vitro techniques. Materials and Methods: C. bonducella powder, soxhlet apparatus, solvents including hexane, DCM, ethyl acetate and methanol. GC-MS, L Caesalpinia bonducella, Fever nut seeds, GC-MS, Anti-inflammatory, Alkaloid https://www.ijper.org/topical-film-forming-clotrimazole-emulgel 2026-04-28T05:16:57.394788+00:00 Topical Film Forming Clotrimazole Emulgel 2023-05-20 10.5530/ijper.57.2s.29 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-250.pdf Introduction: Clotrimazole is a weak base and is practically insoluble in water. To enhance drug loading of hydrophobic Clotrimazole in the formulation and, to circumvent greasiness, poor retention time and easy wipe off associated with conventional topicals, it was formulated as a Film Forming Emulgel. Materials and Methods: Preformulation studies were performed to evaluate solubility and emulsification of drug in oils and surfactants, and screening of gelling and film forming agents. Capryol 9 Adhesive film, Wipe-off resistant, Longer retention, Long term therapy, Antifungal https://www.ijper.org/antidiabetic-properties-of-natural-products-of-cyperus-species-plants-a-review 2026-04-28T05:15:29.027693+00:00 Antidiabetic Properties of Natural Products of Cyperus Species Plants: A Review 2023-05-20 10.5530/ijper.57.2s.26 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-226.pdf Natural products are reported to have a vital role in the treatment of various diseases and drug design. In recent developments, natural drug molecules of plant origin have been reported exclusively for diabetic management. Type-2 diabetes or hyperglycemia is one such disease which is particularly studied for plant-based therapy in the last few decades. Though various plant extracts and metabolites have been reported for potential hyperglycemic activities, the Cyperus species plants have acquire Antidiabetic, α-Glucosidase inhibition, Cyperus articulatus, Cyperus esculentus, Cyperus rotundus, Secondary metabolites https://www.ijper.org/antiproliferative-activity-of-novel-imatinib-analogue-as-potential-anticancer-ag 2026-04-17T09:38:03.785216+00:00 Antiproliferative Activity of Novel Imatinib Analogue as Potential Anticancer Agents, Synthesis and in vitro Screening 2023-05-20 10.5530/ijper.57.2s.53 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-453.pdf Background: A series of N-(2,5-dimethylphenyl)-4-pyridin-3-ylpyrimidin-2-amine derivatives were synthesized as Imatinib derivatives, bearing 2-chloroquinoline as a heteroaryl motif. Materials and Methods: The compounds were synthesized by reducing in situ prepared azomethine intermediate using NaBH4 as a reducing agent in methanol as a solvent. Fourier transformation-IR, proton-NMR along with mass spectrometry were used to determine the structures of the compounds. The antiproliferative activity Imatinib derivatives, Quinoline, Reducing amination, Antiproliferative activity https://www.ijper.org/biofabrication-and-characterization-using-egg-shell-nanoparticles-and-their-haem 2026-04-28T05:19:59.588442+00:00 Biofabrication and Characterization Using Egg Shell Nanoparticles and their Haemolytic Analysis: An in-vitro Study 2023-05-20 10.5530/ijper.57.2s.34 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-301.pdf Aim/Background: Hydroxyapatite is a bioactive, biocompatible, and osteoconductive component having similar chemical characteristics to bone and tooth mineral components. Due to its porous structure and resistance to high temperatures, hydroxyapatite is commonly used as a catalyst and adsorbent. Eggshells are abundant in calcium carbonate, calcium phosphate, and other organic chemicals, making them excellent for CaO production. Materials and Methods: ES-Hap NPs from eggshell through an oil-bath-m Egg shell, Nanoparticles, Hemolytic analysis, XRD, FTIR, FESEM https://www.ijper.org/determination-of-wound-healing-potential-of-pharmaceutical-formulations-gel-and 2026-04-28T05:30:56.161039+00:00 Determination of Wound Healing Potential of Pharmaceutical Formulations (Gel and Paste) Prepared by Using Sea Water Snail 2023-05-20 10.5530/ijper.57.2s.49 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-419.pdf Background: Marine species have long been valued as both nutritious foods for human diets and as a good source of medicinal chemicals. Purpose: The present work aimed to investigate wound healing potential of prepared gel and paste formulation. Materials and Methods: The work involved the preparation of extracts, preparation of formulation using extract and shells of Tibia curta sea water snail and determination of action against wound healing. Sea water snail extract was utilised to make Gels w Shell, Mollusca, Gel, Paste, Wound healing https://www.ijper.org/formulation-and-evaluation-of-double-layered-matrix-and-drug-in-adhesive-transde 2026-04-28T05:15:53.215628+00:00 Formulation and Evaluation of Double-layered (Matrix and Drug-in-adhesive) Transdermal Patches of Diclofenac Diethylamine: In vitro and ex vivo Permeation Studies 2023-05-20 10.5530/ijper.57.2s.27 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-234.pdf Background: The objective of this current study was to fabricate and characterize the sustained release double layered transdermal patches of Diclofenac Diethylamine using hydrophobic acrylic polymer Eudragit RL 100 and hydrophilic polymer Polyvinyl pyrrolidone K-30 in combination as first layer of matrix type patch and pressure sensitive acrylic adhesive Duro Tak 387-2510 as the second layer of drug-in-adhesive type patch to provide sustained anti-inflammatory effect. Materials and Methods: Sol Transdermal patches, Double layered technique, Hydrophobic acrylic polymer, Hydrophilic polymer, Permeation enhancer, Anti-inflammatory https://www.ijper.org/inhalable-solubilized-zileuton-for-improved-lung-targeting-in-vitro-and-in-vivo 2026-04-28T05:20:47.883789+00:00 Inhalable Solubilized Zileuton for Improved Lung Targeting in vitro and in vivo Analysis 2023-05-20 10.5530/ijper.57.2s.35 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-307.pdf Background: Pulmonary diseases that affect the normal functioning of the lungs show airway symptoms ranging from change in airflow to bronchiectasis. Zileuton is an inhibitor of 5-lipoxygenase enzyme that catalyzes the synthesis of leukotrienes. Zileuton is used in the management of inflammatory conditions of the upper airways like obstructive pulmonary conditions and acute lung inflammation. Although a promising therapeutic, zileuton is poorly water-soluble and requires frequent administration Self-emulsifying, Zileuton, Aerosols, Pharmacodynamics, in vivo, Lung targeting https://www.ijper.org/rutin-inhibits-hepatic-and-pancreatic-cancer-cell-proliferation-by-inhibiting-cy 2026-04-17T09:38:00.576273+00:00 Rutin Inhibits Hepatic and Pancreatic Cancer Cell Proliferation by Inhibiting CYP3A4 and GST 2023-05-20 10.5530/ijper.57.2s.48 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-411.pdf Background: Digestive cancer is among the major causes of mortality and morbidity worldwide. Rutin, a bioactive secondary metabolite belonging to flavonoids and distributed in many fruits and vegetables has shown anti-proliferative, anti-cancer, and neuroprotective activities. In this study, the antiproliferative, antioxidant and apoptotic activities of rutin on hepatic and pancreatic cancer cell lines were investigated. Materials and Methods: The effect on cellular viability was monitored by SR Rutin, Pancreatic and Liver cancer, Apoptosis and Anti-inflammatory, Antioxidant https://www.ijper.org/evaluation-of-chemo-preventive-effect-of-methanolic-fruit-extract-of-cucumis-mel 2026-04-28T05:27:06.390513+00:00 Evaluation of Chemo-Preventive Effect of Methanolic Fruit Extract of Cucumis melo var. agrestis on DEN-Induced HCC in Sprague Dawley Rats 2023-05-20 10.5530/ijper.57.2s.42 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-360.pdf Aim: To investigate chemo-preventive effect of methanolic fruit extract of Cucumis melo var. agrestis on DEN (diethyl-nitrosamine) induced hepatocellular carcinoma in Sprague Dawley rats. Materials and Methods: Five groups of rats randomly selected comprising of 6 animals on each group, all groups, except Group-1 were administered single dose of DEN (200 mg/kg, i.p. dissolved in PBS) for the induction of HCC and promoted by phenobarbital (0.05%) for 16 weeks. Group-I was administered only normal Diethyl-nitrosamine, Hepatocellular carcinoma, Methanolic fruit extract of Cucumis melo var. agrestis, 5-Fluro-uracil and Phosphate buffer solution https://www.ijper.org/plga-a-wow-smart-biodegradable-polymer-in-drug-delivery-system 2026-04-28T05:14:47.082182+00:00 PLGA: A Wow Smart Biodegradable Polymer in Drug Delivery System 2023-05-20 10.5530/ijper.57.2s.23 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-189.pdf Aim: This article describes how biodegradable polymers and their drug delivery mechanisms can be used to monitor and maintain local or targeted drug distribution. Polylactic-co-glycol acid has been one of the most appealing polymeric candidates for creating drug release and tissue engineering products over the last couple of decades. PLGA has a variety of purposes due to its biodegradability and biocompatibility. Materials and Methods: The enclosed medicine is delivered from PLGA microparticles PLGA, Biodegradable, Polymer, Drug delivery system, Biocompatible https://www.ijper.org/role-of-remifentanil-on-mac-bcl-2-and-bax-levels-in-traumatic-brain-injury-rat-m 2026-04-28T05:22:15.060261+00:00 Role of Remifentanil on MAC, Bcl-2, and Bax Levels in Traumatic Brain Injury Rat Models 2023-05-20 10.5530/ijper.57.2s.37 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-321.pdf Introduction: Traumatic Brain Injury (TBI) conditions require immediate treatment such as the administration of analgesics and sedation, including remifentanil. TBI will affect the levels of several inflammatory and apoptotic proteins such as MAC, Bax, and Bcl-2. Remifentanil with its high affinity to µ-receptors is thought to affect the levels of these proteins and has neuroprotective properties to prevent secondary brain injury. Objectives: This research aims to determine the effect of giving Bax, Bcl-2, MAC, Remifentanil, Traumatic brain injury https://www.ijper.org/nutritional-assessment-of-invasive-alien-plants-as-bioprospecting-resources-in-m 2026-04-28T05:27:56.715415+00:00 Nutritional Assessment of Invasive Alien Plants as Bioprospecting Resources in Mizoram, an Indo-Burma Mega Biodiversity Hotspot in India 2023-05-20 10.5530/ijper.57.2s.44 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-381.pdf Background: The nutritional value, antinutritional properties, mineral and Vitamin content of six invasive Alien Plant species (IAPs) namely Ageratina adenophora, Ageratina riparia, Chromolaena odorata, Ocimum americanum, Bidens pilosa and Hyptis suaveolens which are used by the local inhabitants in Mizoram, India was analysed. Materials and Methods: The proximate composition, antinutritional contents, mineral and Vitamin content were investigated following standard analysis protocols. Tannins, Invasive alien plants, Antinutrients, Mizoram, Minerals content, Proximate composition, Vitamin https://www.ijper.org/effect-of-process-variables-on-the-development-and-characterization-of-nanocellu 2026-04-17T09:38:05.28799+00:00 Effect of Process Variables on the Development and Characterization of Nanocellulose as Novel Biopolymer 2023-03-27 10.5530/ijper.57.1s.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-32.pdf Nanocellulose has excellent mechanical, physical, and biological properties; it is an ideal material for many applications. The present study aimed to develop nanocellulose from cellulose by hydrolyzing with sulphuric acid to yield nanocellulose. In order to prepare nanocellulose, two factors were considered: the concentration of sulphuric acid and the variation in temperature (AHNC1 to AHNC5). Optimized NC was characterized by its size, zeta potential, TEM, XRD, and FT-IR. NCs had a size range Nanocellulose, Acid hydrolysis, CNC, CNF, Nanocrystals https://www.ijper.org/transmissible-spongiform-encephalopathy-and-its-regulations 2026-04-28T04:40:40.588792+00:00 Transmissible Spongiform Encephalopathy and its Regulations 2023-03-27 10.5530/ijper.57.1s.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-7.pdf Bovine Spongiform Encephalopathy (BSE) has a place with the uncommon cluster of continuously progressive neurological infections identified as Transmissible Spongiform Encephalopathies (TSEs). TSE sicknesses are described by long incubation periods ranging from a while for transmissible mink encephalopathy, to several years for BSE. TSE consistence testaments are a sort of CEP (Certificate of Suitability). During the 1980s, when the principal TSE pandemic happened, researchers started centering Degenerative disorder, Prion, Transmissible, Bovine, Spongiform, Regulation https://www.ijper.org/production-of-l-tyrosinase-from-novel-variants-of-streptomyces-cellulosae 2026-04-28T04:41:06.863003+00:00 Production of L-tyrosinase from Novel Variants of Streptomyces cellulosae 2023-03-27 10.5530/ijper.57.1s.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-22.pdf Background: Recently, a lot of interest has been focused on the discovery of high L-tyrosinase yielding microorganisms that catalyze the production of enantiomerically pure L-DOPA, which has been recognized as the conventional treatment for Parkinson's disease. Objectives: The current work primarily focused on isolating novel, promising tyrosinase-producing isolates and performing taxonomical characterization on them. Materials and Methods: Initially six various actinomycetes isolates were used Tyrosinase, L- tyrosine, L-DOPA, SS medium, copper sulphate, Streptomyces cellulosae https://www.ijper.org/prevalence-of-drug-related-problems-in-elderly-cancer-patients-a-prospective-obs 2026-04-28T04:47:07.421328+00:00 Prevalence of Drug-Related Problems in Elderly Cancer Patients: A Prospective Observational Study in a Cancer Specialty Hospital 2023-03-27 10.5530/ijper.57.1s.17 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-148.pdf Background: The geriatric population comprises the majority of patients with oncological disorders. They are highly vulnerable to drug-related problems (DRPs) due to multiple comorbidities, polypharmacy, altered pharmacokinetics and pharmacodynamics. This study aimed to determine the rate and pattern of drug-related problems in elderly cancer patients. Materials and Methods: A observational study was conducted prospectively for a period of 4 months, where cancer patients of any gender above 60 y Drug-related problems, Geriatric oncology, Cancer, Polypharmacy https://www.ijper.org/development-and-evaluation-of-fast-dissolving-oral-films-of-mefenamic-acid-for-t 2026-04-17T09:38:05.125719+00:00 Development and Evaluation of Fast Dissolving Oral Films of Mefenamic Acid for the Management of Fever 2023-03-27 10.5530/ijper.57.1s.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-41.pdf The marketed formulations of Mefenamic Acid (MA) used for the treatment of fever in the paediatric population are reported to have several drawbacks. This study aimed to develop and evaluate the mefenamic acid–loaded oral dispersible films which may be a better alternative than the existing formulations. The solubility of mefenamic acid was enhanced by forming inclusion complexes with β cyclodextrin. The best ratio for the mefenamic acid-β cyclodextrin inclusion complex, 1:0.5 was selected based Oral dispersible films, Mefenamic acid, β Cyclodextrin, Paediatric, Kneading method, Solvent casting https://www.ijper.org/analog-based-design-and-development-of-novel-molecules-as-anti-tubercular-agents 2026-04-28T04:45:09.018829+00:00 Analog-based Design and Development of Novel Molecules as Anti-tubercular Agents 2023-03-27 10.5530/ijper.57.1s.12 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-105.pdf Background: The burden of tuberculosis is immense as most of the drugs developed resistance to Mycobacterium tuberculosis (Mtb). This issue shall be addressed by developing new drugs acting through novel mechanisms. GSK 2556286 (GSK-286) is a phase 1 clinical candidate with a novel mechanism of action related to cholesterol catabolism, hence it was selected as template/parent molecules for our analogue-based drug design strategy. Materials and Methods: The novel-designed molecules were initially Analog-based Design, Anti-tubercular activity, BBB permeability, GSK 2556286, VERO cells https://www.ijper.org/formulation-and-evaluation-of-niosomal-gel-loaded-with-asparagus-racemosus-extra 2026-04-28T04:43:09.496861+00:00 Formulation and Evaluation of Niosomal Gel Loaded with Asparagus racemosus Extract for Anti-inflammatory Activity 2023-03-27 10.5530/ijper.57.1s.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-63.pdf Background/Aim: Inflammation typically occurs when infectious microorganisms enter the body, settle in specific tissues, and/or circulate in the blood. Asparagus racemosus extract contains various saponins and flavonoids and plant-origin drugs have fewer side effects and toxicity. The phytoconstituents have less permeability through the skin; to enhance their permeability and effectiveness it was loaded in niosomes. Therefore, the study aimed to formulate and characterize the niosomal gel loaded Asparagus racemosus, Niosomes, Span 60, Cholesterol, Factorial design, Carbopol 934 https://www.ijper.org/a-meta-analysis-on-misuse-of-prescriptionotc-drugs-how-pharmacist-can-prevent-an 2026-04-17T09:38:07.983928+00:00 A Meta-Analysis on Misuse of Prescription/OTC Drugs: How Pharmacist Can Prevent and Manage Drug Abuse 2023-03-27 10.5530/ijper.57.1s.20 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-167.pdf Background: Drug misuse is a critical issue related to both physical and psychological health associated with growing threats across the world. The role of pharmacist in preventing drug abuse is crucial to address prescription/OTC medication misuse. Aim and Objectives: To synthesize the research on misuse of prescription/OTC drugs, role of pharmacist in preventing and managing prescription/OTC medications induced health conditions and to provide methodological guidance for further research. Mate Prescription drug misuse, OTC medication abuse, Opioid abuse, Meta-analysis https://www.ijper.org/medication-reconciliation-practices-in-two-multispeciality-hospitals 2026-04-17T09:38:08.149964+00:00 Medication Reconciliation Practices in Two Multispeciality Hospitals 2023-03-27 10.5530/ijper.57.1s.18 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-153.pdf Background: Medication errors are common and can compromise patient safety. Commonly seen at discharge, they can be identified and resolved even during admission. Medication reconciliation is recommended to prevent errors arising from medication discrepancies. Aim: To conduct medication reconciliation in two multispeciality hospitals and classify the identified medication discrepancies according to their potential to cause harm. Materials and Methods: This prospective interventional study was ca Medication reconciliation, Clinical pharmacist, Medication discrepancies, Medication errors https://www.ijper.org/IndJPhaEdRes-57-1s-i 2026-04-13T05:54:21.572312+00:00 Editorial 2023-03-27 10.5530/ijper.57.1s.i https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-i.pdf 25th Annual National Convention of Association of Pharmaceutical Teachers of India (APTI) was organized by JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru from 2nd September to 4th September 2022 at JSS Medical Institutions Campus, Mysuru. The theme of the conference was “Empowering Academia for Advancing Pharmacy Education”. About two thousand pharmacy professionals, students, industrialists, scientists, and leaders from different states of the country took part in t Editorial https://www.ijper.org/formulation-and-evaluation-of-aspirin-plga-microsphere-for-the-dental-stem-cell 2026-04-28T04:42:07.868713+00:00 Formulation and Evaluation of Aspirin-PLGA Microsphere for the Dental Stem Cell Stimulation 2023-03-27 10.5530/ijper.57.1s.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-52.pdf Aim: According to WHO, dental caries is the most prevalent oral disease, and its progression leads to tooth loss. Clinical management of caries focuses on the severity and extent of disease with the main aim, i.e., the ‘art’ of creating a good restoration. Recently, it has been reported that aspirin can stimulate existing stem cells and regenerate damaged teeth. But, the therapeutic effectiveness of a drug depends on developing a suitable novel drug delivery system, to retain at the site and sui Stem cell, Dental caries, Sustained release, Aspirin, Dentinogenesis, Microsphere https://www.ijper.org/synthesis-antidiabetic-evaluation-and-molecular-docking-studies-of-thiazolidine 2026-04-17T09:38:07.653205+00:00 Synthesis, Antidiabetic Evaluation and Molecular Docking Studies of Thiazolidine-2,4-Dione Analogues 2023-03-27 10.5530/ijper.57.1s.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-98.pdf Introduction: Diabetes Mellitus is a disorder of metabolism described by high glucose levels. The disorder kills a larger number of individuals consistently than of malignant growth and AIDS combined. Presently available drugs have several drawbacks forcing to withdraw from treatment. The potent side effect i.e., hepatotoxicity and cardiovascular toxicity limits the use of thiazolidine-2,4-dione derivative as safe drugs. Our aim is towards the development of synthetic compounds as potential anti Thiazolidine-2,4-dione, Molecular docking, Antidiabetic evaluation, Swiss albino mice https://www.ijper.org/preparation-and-in-vitro-and-in-vivo-evaluation-of-ayurvedic-formulation-amrutho 2026-04-28T04:46:00.280547+00:00 Preparation and in-vitro and in-vivo Evaluation of Ayurvedic Formulation “Amruthotharam” Formulated by Classical and Modern Technique 2023-03-27 10.5530/ijper.57.1s.14 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-126.pdf Glucose intolerance, central obesity, hypertension, and dyslipidemia are all part of the metabolic syndrome. Thus, a number of theories have been put out to explain the development of the metabolic syndrome, including an initial condition of insulin resistance that progressed to the other elements, with obesity serving as the primary initiator of the metabolic syndrome. Thus, it can be understood that metabolic syndrome is multi related and the basic cause is inflammation. Thus, while treating t Metabolic syndrome, Amruthotharam, Immunomodulatory https://www.ijper.org/assessment-of-solid-state-behaviour-and-in-vitro-release-of-artemether-from-liqu 2026-04-17T09:38:06.646667+00:00 Assessment of Solid-State Behaviour and in vitro Release of Artemether from Liquisolid Compact Using Mesoporous Material as an Excipient 2023-03-27 10.5530/ijper.57.1s.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-13.pdf Background: Artemether is a potent antimalarial drug used in the first-line treatment of multi-drug-resistant malaria. It belongs to BCS II, exist in different polymorphic forms, and exhibits incomplete absorption and low oral bioavailability owing to poor dissolution. Aim: The present study evaluates the effect of different mesoporous materials in the liquisolid compact for the augmentation of dissolution of the drug, and polymorphic stability. Materials and Methods: In the liquisolid compact T Artemether, Liquisolid compact, Solid-state behaviour, Dissolution, Mesoporous silica https://www.ijper.org/orphan-drug-pricing-and-cost-trends-in-usa-an-analysis-of-impact-of-orphan-drug 2026-04-28T04:40:18.986107+00:00 Orphan Drug Pricing and Cost Trends in USA: An Analysis of Impact of Orphan Drug ACT 2023-03-27 10.5530/ijper.57.1s.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-1.pdf Objectives: The study analyses the impact of incentives in Orphan Drug Act on Orphan Drug revenue strategies of pharmaceutical and biotechnology companies in USA and proposes policies and steps to address the same. Results: There are 389 orphan drugs in circulation as of 2019 with average price of $32,000; prices ranging between $6,000 till more than $500,000. 39% of the marketed drugs costing more than $100,000 treats 23% of patient population. Out of 1.8 million treated patients in 2019, only Orphan Drug Act, Orphan drug, Rare Disease, Volume Based Contract, Outcome Based Contract, Value Based Pricing https://www.ijper.org/perceptions-of-indian-physicians-towards-deprescribing-of-medications-for-chroni 2026-04-28T04:47:42.907502+00:00 Perceptions of Indian Physicians towards Deprescribing of Medications for Chronic Diseases in Elderly: A Questionnaire-based Study 2023-03-27 10.5530/ijper.57.1s.19 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-160.pdf Deprescribing is the process of reconstructing multiple medications use by review and analysis, which concludes with the modification, replacement or elimination of drugs. Medications that were once appropriate may become inappropriate due to age-related physiological changes that increase the risk of harm from medications eliminated by the liver and kidneys and other co-morbidities. In India, with a steadfast rise in the elderly population paralleled with an augmented necessity for chronic dise Comorbidities, Polypharmacy, Deprescribing, Elderly patients https://www.ijper.org/assessment-of-adherence-and-common-non-adherence-factors-for-inhaled-medications 2026-04-17T09:38:06.807546+00:00 Assessment of Adherence and Common Non-adherence Factors for Inhaled Medications in Asthma and Chronic Obstructive Pulmonary Disease (COPD) Patients 2023-03-27 10.5530/ijper.57.1s.22 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-183.pdf Background: Inhaled medications are the cornerstone for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Adherence of inhaled medications can be influenced by many factors such as patient preferences, education and awareness. Therefore, it is fundamental to identify and address the factors that helps to improve adherence to inhaled medications. Materials and Methods: A prospective observational study was conducted at the department of respiratory medicine for 6 months in Asthma, Chronic obstructive pulmonary disease (COPD), Medication adherence, Medication adherence questionnaire, Non-adherence factors https://www.ijper.org/pharmacophore-based-high-throughput-virtual-screening-towards-the-discovery-of-n 2026-04-17T09:38:05.43966+00:00 Pharmacophore based High Throughput Virtual Screening towards the Discovery of Novel BLK (B-lymphocyte kinase)-tyrosine Kinase Inhibitors 2023-03-27 10.5530/ijper.57.1s.21 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-174.pdf Aim: LK (B-lymphocyte kinase) is a protein from the family SRC (Proto-oncogene tyrosine-protein kinase), an important cell signaling molecule that influences cellular response. The BLK tyrosine-protein kinase has been a potential target for cancer therapy. As a result, this could be an initial step toward the development of novel inhibitors to fight cancer. Materials and Methods: A homology model of human BLK tyrosine kinase was constructed using Phyre2. Active site prediction was done for the m Pharmacophore modeling, Molecular docking, BLK tyrosine kinase, Cancer https://www.ijper.org/terbinafine-hcl-film-forming-spray-for-the-treatment-of-topical-fungal-infection 2026-04-28T04:44:14.368792+00:00 Terbinafine HCl Film-Forming Spray for the Treatment of Topical Fungal Infections 2023-03-27 10.5530/ijper.57.1s.10 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-85.pdf Terbinafine HCl is an allylamine used to treat fungal infections. It has substantial side effects that can be mitigated by using a topical semisolid dose form. The objective of this study was to develop a 1% Terbinafine HCl film-forming spray formulation to treat topical fungal infections. The formulation was developed by combining polymers, penetration enhancer, plasticizer, and a suitable solvent system. The central composite design with 3 independent variables and 2 dependent variables is imp Terbinafine HCl, Formulation, Fungal infection, Solid dosage forms, Ethyl cellulose https://www.ijper.org/evaluation-of-immunomodulatory-effect-of-aqueous-extract-of-bauhinia-variegata-l 2026-04-28T04:46:16.756951+00:00 Evaluation of Immunomodulatory Effect of Aqueous Extract of Bauhinia variegata L. Leaves 2023-03-27 10.5530/ijper.57.1s.15 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-135.pdf Natural products have the potential to modulate the immunity of human beings either by stimulating or depressing it and the approach was being used over time by medicinal practitioners to treat ailments. This present study was planned to ascertain the immunomodulating potential of one of the Indian traditional medicinal plants Bauhinia variegata L. The aqueous extract of powdered leaves of Bauhinia variegata L. was prepared by using the decoction method and the extract was then dried and made fr Bauhinia variegata, Cellular immune response, Haemagglutination, Humoral study, Immunomodulation https://www.ijper.org/formulation-and-evaluation-of-castor-oil-containing-self-emulsifying-pellets-by 2026-04-28T04:43:58.810762+00:00 Formulation and Evaluation of Castor Oil Containing Self-emulsifying Pellets by Using Design of Experiment 2023-03-27 10.5530/ijper.57.1s.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-75.pdf Background/Objectives: The objective of the study was to examine the feasibility of extrusion/spheronization techniques for formulation of castor oil loaded self-emulsifying pellets. The study was also aimed at optimization of the self-emulsifying pellet system with design of experiments. Materials and Methods: Various surfactants and co-surfactants were tested for their ability to emulsify castor oil. The proportion of components (castor oil, surfactant and co-surfactant) in self-emulsifying pe Solid self-emulsifying drug delivery system, Castor oil, Self-emulsifying pellets, Extrusion spheronization, Dispersion time https://www.ijper.org/an-alternative-excipient-from-vegetable-source-for-oral-drug-dosage-forms-to-reg 2026-04-17T09:38:07.477509+00:00 An Alternative Excipient from Vegetable Source for Oral Drug Dosage Forms to Regulate Drug Delivery 2023-03-27 10.5530/ijper.57.1s.13 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-114.pdf Introduction: Tablet is the preferred drug dosage form. Cellulose fiber (Micro Crystalline Cellulose) is the major excipient used. For chronic diseases, frequent dosage is required resulting in cumulative excipient load and tachyphylaxis due to drug. We intent to invent excipients from vegetable sources to mitigate above challenges and reduce dosage as chronic sufferers (Diabetes mellitus) requires lifelong treatment. Aims and Objectives: To develop an excipient from Brassica oleracea and Vigna Herbal excipients, Cellulose fibers, Microcrystalline cellulose, Tachyphylaxis, Vegetable source excipient, Brassica oleracea, Vigna radiata, Metformin, Miglitol https://www.ijper.org/cost-minimization-analysis-of-medications-used-in-the-management-of-end-stage-re 2026-04-28T04:46:42.234032+00:00 Cost-Minimization Analysis of Medications Used in the Management of End-stage Renal Disease 2023-03-27 10.5530/ijper.57.1s.16 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1s-140.pdf Aim/Background: Several branded pharmaceuticals and generic medicines are available in the market for the management of End-Stage Renal Disease (ESRD) as a supportive care, and clinicians are unaware of the cost minimization and cost consequences aspects of these medications. Thus, this study aimed to compare the prices of branded versus generic medicines for ESRD treatment and to present the cost savings with a generic alternative. Materials and Methods: A prospective observational study was co Pharmacoeconomics, Cost minimization, End stage renal disease, Antibiotics, Insulin, Jan Aushadhi https://www.ijper.org/characterization-and-biofabrication-of-silver-nanoparticles-utilizing-isochrysis 2026-04-28T04:59:14.511157+00:00 Characterization and Biofabrication of Silver Nanoparticles Utilizing Isochrysis Extract along with its in vitro Antibacterial and Antioxidant Applications 2023-03-21 10.5530/ijper.57.2.55 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-449.pdf Background: At present, bio-green methods are more expedient than physical and chemical approaches due to their prompt, simple, lucrative, scalable and conservational synthesis of nanoparticles. Aim: This study investigates the extracellular biogenic synthesis of silver nanoparticles (AgNPs) using the ethanolic-hexane extract of Isochrysis sp. (EHEI). Materials and Methods: Biosynthesized AgNPs were nano-characterized by UV-Vis spectroscopy, Field Emission Scanning Electron Microscope (FESEM), D Isochrysis, AgNPs, FESEM, GCMS, Antibacterial, Antioxidant https://www.ijper.org/quinine-attenuates-cigarette-smoke-extract-induced-mucosal-inflammation-and-oxid 2026-04-28T05:02:09.715068+00:00 Quinine Attenuates Cigarette Smoke Extract Induced Mucosal Inflammation and Oxidative Stress in the Zebrafish Model 2023-03-21 10.5530/ijper.57.2.60 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-496.pdf Introduction: Smoking is the primary cause of Chronic obstructive pulmonary disease (COPD) leading to alarming increase in worldwide death. Cigarette smoking is a dangerous risk factor in causing mucosal inflammation and lung damage caused by nicotine, which is more addictive than other narcotics. This study was undertaken to assess the potential of quinine in ameliorating the cigarette smoke extract (CSE) induced inflammation in the Zebrafish model. Materials and Methods: CSE was extracted in w Cigarette smoke extracts, Mucosal inflammation, Quinine, ROS, Zebrafish https://www.ijper.org/anti-mitotic-activities-of-ethanolic-extract-and-glutinol-from-uvaria-rufa-blume 2026-04-28T05:04:37.075307+00:00 Anti-mitotic Activities of Ethanolic Extract and Glutinol from Uvaria rufa Blume 2023-03-21 10.5530/ijper.57.2.64 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-526.pdf Background: This study describes the isolation of major chemical constituent from the bark of Uvaria rufa Blume, commonly known as “allagat or susong kalabaw”, an indigenous Philippine medicinal plant that belongs to the family Annonaceae. It is a short climbing shrub that grows in low and medium-altitude forests in the country. Materials and Methods: The bark samples of U. rufa were air-dried for three months without exposure to sunlight. The samples were ground in a blender, then, soaked in CH Uvaria rufa, Allagat, Glutinol, Anti-mitotic, Triterpene https://www.ijper.org/caryota-urens-and-hyophorbe-lagenicaulis-as-nutraceutical-by-managing-commercial 2026-04-28T05:03:13.657835+00:00 Caryota urens and Hyophorbe lagenicaulis as Nutraceutical by Managing Commercially Available Drug Induced Nephrotoxicity 2023-03-21 10.5530/ijper.57.2.61 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-503.pdf Background: Caryota urens flowers and Hyophorbe lagenicaulis leaves have huge beneficial properties, medicinal uses and rich phyto-pharmacological constituents. Nutraceutical potentiality of the selected plants on the basis of phytochemicals present in the aerial parts of Caryota urens and Hyophorbe lagenicaulis were taken as the background of the study. Aim: The present study investigates the nephroprotective potentiality of Caryota urens flowers and Hyophorbe lagenicaulis leaves against cispla Nutraceuticals, Phytochemical, Cisplatin, Gentamycin, Nephrotoxicity https://www.ijper.org/separation-of-bio-active-compounds-and-in-vitro-antibacterial-potency-of-callist 2026-04-28T04:59:47.897954+00:00 Separation of Bio-active Compounds and in vitro Antibacterial Potency of Callistemon linearis Floral Extract with Mechanism of Action 2023-03-21 10.5530/ijper.57.2.58 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-478.pdf Introduction: Infection caused by bacteria is treated with antibiotics which caused several side effects in human and animals. This problem enforced scientist to work out plant originated compounds for treatment of several disease caused by morbific bacteria. Objectives: Present work revealed isolation of bioactive phytocompounds from different fractions of Callistemon linearis flower ethanol extract by chromatographic technique and determination of their antibacterial potency against selected b Callistemon linearis, Antibacterial activity, FT-IR, GC-MS analysis, Bioactive compounds, Mechanism of action https://www.ijper.org/measurement-of-process-capability-of-manufacturing-process-of-levetiracetam-by-a 2026-04-28T04:55:15.305038+00:00 Measurement of Process Capability of Manufacturing Process of Levetiracetam by Applying Concept of Six Sigma 2023-03-21 10.5530/ijper.57.2.48 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-386.pdf Background: A process capacity study is a study that uses capability indices to compare the output of an in-control process to specification constraints. Cp, Cpk, Ppk, and Pp are some of the statistics that can be used to assess process capability. The goal of the six-sigma study of levetiracetam tablets is to enhance and adjust the process to produce defect-free tablets and to maximize customer satisfaction. Process capability guarantees that procedures meet industry firm specifications while l DMAIC phases, Epilepsy disorder, Levetiracetam, Process capability index, Six sigma process https://www.ijper.org/subtle-intricacies-identified-during-streptozotocin-induced-diabetes-in-wistar-r 2026-04-28T05:07:01.994648+00:00 Subtle Intricacies Identified during Streptozotocin-Induced Diabetes in Wistar Rats 2023-03-21 10.5530/ijper.57.2.67 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-547.pdf Aim: This study aimed to establish the dose of streptozotocin required to induce Type -1 diabetes in Wistar rats. Background: Streptozotocin is currently employed worldwide to induce insulin-dependent diabetes mellitus also known as Type 1 diabetes mellitus in experimental animals. Though many reports on the use of streptozotocin induction of diabetes are reported in the literature, they were not reproducible. Moreover, there was no mention of the mortality associated with the same as well as th Male Wistar rats, Streptozotocin, Type-1 diabetes, 5% dextrose, Mortality, Normal saline solution https://www.ijper.org/design-development-and-in-vitro-evaluation-of-hydrogels-prepared-by-free-radical 2026-04-28T04:58:48.050432+00:00 Design, Development and in vitro Evaluation of Hydrogels Prepared by Free Radical Polymerization of Acrylic Acid (AAc) Containing a Model Antidiabetic Drug 2023-03-21 10.5530/ijper.57.2.54 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-432.pdf Introduction: The controlled release of medicaments in the management of diabetes is desirable to have a better therapeutic activity of the drug. Objectives: In the present study hydrogels were prepared as a controlled drug delivery system taking Rosiglitazone as a model drug. Materials and Methods: Hydrogels were created using the Free Radical Polymerization approach, with the crosslinker N, N′-Methylene bisacrylamide serving as a binding agent for the polymerization. To create a polymeric netw Hydrogels, PVP Acrylic acid, Free Radical Polymerization, Antidiabetic Drug https://www.ijper.org/design-and-development-of-multiparticulate-mini-tablets-of-verapamil-hydrochlori 2026-04-17T09:38:09.384235+00:00 Design and Development of Multiparticulate Mini Tablets of Verapamil Hydrochloride for Pulsatile Drug Delivery 2023-03-21 10.5530/ijper.57.2.50 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-401.pdf Objectives: The objective of the research was to develop and evaluate the multiparticulate pulsatile release minitablets of verapamil hydrochloride for the treatment of hypertension at a desired time to mimic the circadian rhythms and improve the patient compliance. Materials and Methods: Formulation was prepared by CODAS technology. It was designed to initiate the release of verapamil after 4h lag time and reached the therapeutic levels at in the early morning hours, when the blood pressure is Multiparticulates, Pulsatile release minitablets, Verapamil hydrochloride, Chronotherapeutic drug delivery, Fumaric acid, ethylcellulose https://www.ijper.org/transformation-of-pharma-curriculum-as-per-the-anticipation-of-pharma-industries 2026-04-28T04:51:20.543909+00:00 Transformation of Pharma Curriculum as Per the Anticipation of Pharma Industries-Need to Empower Fresh Breeds with Globally Accepted Pharma Syllabus, Soft Skills, AI and Hands-on Training 2023-03-21 10.5530/ijper.57.2.41 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-320.pdf In this domain of specialty and globalization the pharmacy teaching and learning in India is suffering from serious backdrops and flaws. In India, in present-day need of pharmacy is to physique and shape strategies for a renovated innovative future for affordable and effective healthcare system. There is a crucial necessity to begin an academic exercise aimed at renewing of prospectus, focusing recent and evolving learnings in the field of pharmacy. The current youth of pharmacy graduate sought Pharmacy Education, Pharma Industries, Latest Development, Pharma 4.0, Artificial Intelligence https://www.ijper.org/new-data-for-endemic-phlomis-cypria-post-from-north-cyprus-biological-activities 2026-04-28T05:03:55.566478+00:00 New Data for Endemic Phlomis cypria Post from North Cyprus: Biological Activities and LC MS/MS Analysis 2023-03-21 10.5530/ijper.57.2.62 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-511.pdf Background: The genus Phlomis includes up to 100 species which are distributed throughout Eurasia. Of these species, Phlomis cypria Post (Lamiaceae) is an endemic plant from North Cyprus. P. cypria is commonly used in North Cyprus as medicinal herbal tea for the winter cold and flu. Phlomis species have antioxidant, antimicrobial and anticancer effects. Materials and Methods: In this study, herbal part of P. cypria from North Cyprus was sequentially extracted using hexane, dichloromethane and 70 Phlomis cypria, Lamiaceae, Antioxidant, Cytotoxicity, Antibacterial, Anticholinesterase https://www.ijper.org/chemical-composition-antioxidant-and-anti-tumor-activities-of-the-aerial-parts-o 2026-04-17T09:38:10.224619+00:00 Chemical Composition, Antioxidant and Anti-tumor Activities of the Aerial Parts of Cometes abyssinica R.Br. ex Wall 2023-03-21 10.5530/ijper.57.2.56 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-459.pdf An in vitro bioassay-guide revealed that the methanolic extract of the aerial parts of Cometes abyssinica had considerable inhibitory activity against colon (HCT-116) and hepatocellular (HepG2) carcinoma cell lines with IC50 24.4 and 29.9 μg/mL, respectively, compared to the drug reference Cisplatin. On the other hand, all studied extracts exhibited weak antioxidant activities using the DPPH scavenging assay with IC50 values between 543-826.4 μg/mL. Phytochemical investigation of the methanol an Cometes abyssinica, Aerial parts, Chemical constituents, Flavonoids, Antioxidant activity, Antitumor activity https://www.ijper.org/a-comparative-evaluation-of-various-therapies-of-synthetic-drugs-with-amla-and-h 2026-04-28T05:05:22.80159+00:00 A Comparative Evaluation of Various Therapies of Synthetic Drugs with Amla and Honey Combination for the Treatment of Gastroesophageal Reflux Disease 2023-03-21 10.5530/ijper.57.2.66 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-540.pdf Background: Gastroesophageal Reflux Disease (GERD) is disorder of oesophagus that causes ulcer and erosion. Materials and Methods: A comparison based on the in vivo study was carried out to determine the therapeutic efficacy of herbal formulation using Amla and Honey in combination with Pantoprazole and Rebamipide for the treatment of GERD. The effects of all above mentioned medications were also checked on intestinal motility. In vitro studies were carried out to determine the antispasmodic act Combination therapy, Mono-therapy, Pantoprazole, Rebamipide, Mucosal https://www.ijper.org/in-vitro-antioxidant-cytotoxicity-study-on-eac-cell-line-of-quinazolin-43h-one-d 2026-04-28T05:05:04.058441+00:00 In vitro Antioxidant, Cytotoxicity Study on EAC Cell Line of Quinazolin-4(3H)-one Derivatives: Synthesis, Molecular Docking, in silico Drug Likeness 2023-03-21 10.5530/ijper.57.2.65 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-531.pdf Aim: The quinazolin-4(3)-one exist an important sort of therapeutic drug candidates which attain integer of biological actions. In this research intended on design, synthesis, and Drug likeness, screened their antioxidant by DPPH method, Cytotoxicity tumor cell line by EAC method. Materials and Methods: The existing amendment evaluated their antioxidant actions of quinazolin-4(3H)-one derivatives (1-8) using Assay of 2,2-diphenyl-1-picryl hydrazyl radical scavenging (DPPH) followed by in vitro c Quinazolin-4(3H)-one, Antioxidant activity, Cyto-toxicity, Molecular docking, DPPH Method, EAC method https://www.ijper.org/how-should-we-think-about-pharmaceutical-excipients-in-clinical-pharmacy-educati 2026-04-17T09:38:12.108053+00:00 How Should We Think About Pharmaceutical Excipients in Clinical Pharmacy Education? 2023-03-21 10.5530/ijper.57.2.46 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-372.pdf Background: As the pharmaceutical industry shifts to a patient-oriented approach, pharmaceutical education has fairly garnered increasing attention from educators, so that the teaching course centered on pharmaceutical excipients is becoming more and more popular. Purpose: The purpose of this study was to evaluate the significance of pharmaceutical excipients in clinical pharmaceutical education by a single-blind and parallel group design. Materials and Methods: The course was given in the form Clinical pharmacy education, Pharmaceutical excipients, Parallel group design, Teaching improvement https://www.ijper.org/the-impact-of-an-educational-module-on-pharmacovigilance-towards-improving-knowl 2026-04-17T09:38:11.736809+00:00 The Impact of an Educational Module on Pharmacovigilance towards Improving Knowledge and Attitude of Nursing and Pharmacy Students 2023-03-21 10.5530/ijper.57.2.73 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-598.pdf Background: Pharmacovigilance is an integral part of patient safety and rational use of medicines. It is the professional responsibility of not just physicians but also of other health care professionals who use medicines such as nurses and pharmacists. Therefore it is essential to create awareness about pharmacovigilance through an educational module during their undergraduate course. Objectives: 1. To evaluate the knowledge and attitude of nursing and pharmacy students towards pharmacovigilanc Educational intervention, Learning, Pharmacovigilance, Nurses, Pharmacists https://www.ijper.org/evaluation-of-the-effect-of-pheophytin-a-on-electroshock-induced-seizures-in-exp 2026-04-17T09:38:13.643137+00:00 Evaluation of the Effect of Pheophytin A on Electroshock-Induced Seizures in Experimental Animals 2023-03-21 10.5530/ijper.57.2.52 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-418.pdf Background: An epileptic seizure is a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain. Approximately, 5–10% of the people have at least one kind of seizure, with more chance of occurrence in early childhood and late adulthood. There are many drugs used in seizures such as phenytoin and valproate sodium, so the main objective of current study was evaluated the efficacy of Pheophytin A compared to Valproate sodium on electroshoc Seizures, Pheophytin A, Valproate sodium, Maximal electroshock seizure, In vivo https://www.ijper.org/pharmacist-a-healthcare-professional-serving-as-frontline-warrior-completely-ove 2026-04-28T04:51:54.969372+00:00 Pharmacist: A Healthcare Professional Serving as Frontline Warrior Completely Overlooked 2023-03-21 10.5530/ijper.57.2.43 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-337.pdf During the tough times of SARS-CoV-2 (COVID-19), the pharmacy professionals played a significant role by providing their services at various working stations and levels including hospitals, private clinics, community pharmacies, nursing homes, pharmaceutical industries, CROs and various health care programmes. However, the services provided by pharmacists were seldom mentioned and the professionals were not recognized as first line health care professional. The media, authorities and even genera Coronavirus, Global health, Pandemic, Pharmacists, Pharmacy https://www.ijper.org/evaluation-of-nootropic-potential-of-the-fruits-of-artocarpus-altilis-by-in-vivo 2026-04-17T09:38:11.21597+00:00 Evaluation of Nootropic Potential of the Fruits of Artocarpus altilis by in vivo and in vitro Studies 2023-03-21 10.5530/ijper.57.2.63 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-519.pdf Background: Artocarpus altilis is an evergreen plant having a variety of medicinal values due to the presence of compounds like cyclopropane sterols, quercetin, camphorol, artocarpine, and many more. The fruits typically contain cycloprane sterols. Objectives: The present study was carried out to evaluate the nootropic potential of the ethanolic extract of the fruits of Artocarpus altilis (EFAA). Materials and Methods: The nootropic activity was evaluated using various models. The animals were d Acetyl-cholinesterase, Amnesia, Artocarpus altilis, Cognitive functions, Scopolamine https://www.ijper.org/synthesis-and-biological-evaluation-of-the-selected-naphthalene-substituted-azet 2026-04-17T09:38:11.048755+00:00 Synthesis and Biological Evaluation of the Selected Naphthalene Substituted Azetidinone Derivatives Targeting Parkinson’s Disease 2023-03-21 10.5530/ijper.57.2.68 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-552.pdf Aim/Background: Parkinson’s Disease (PD), the loss of dopaminergic neurons in the substantial nigra part of the brain leading to neurodegeneration. Materials and Methods: The objective of this study was to observe the neuroprotective effect of the synthesized derivatives in 6-hydroxydopamine (6-OHDA) induced rat model. Here, designed naphthalene substituted azetidinone compounds defended the lesions caused by 6-OHDA in rat model for PD. Male wistar rats (250g) were subjected into sham operated, Schiff’s bases, Azetidinone, Anti-Parkinson’s activity, Neurodegeneration, 6-OHDA https://www.ijper.org/enhancing-pharmaceutical-supply-chain-resilience-a-study-of-pharmaceutical-compa 2026-04-28T05:10:31.398083+00:00 Enhancing Pharmaceutical Supply Chain Resilience: A Study of Pharmaceutical Companies in Multiple Geographies 2023-03-21 10.5530/ijper.57.2.74 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-603.pdf Background: Pharmaceutical businesses had enormous difficulties in product distribution during COVID-19, and the solution to this perpetual issue is a resilient supply chain. Aim: The study aims to understand the vulnerabilities to which it subjected the pharmaceutical product distribution supply chains during the COVID-19 pandemic and further develop an adaptive model through which the pharmaceutical product supply chain can enhance its resilience capabilities. Materials and Methods: The concep Supply Chain Resilience, Trade cost, Shock propagation, Technological infrastructure bottleneck https://www.ijper.org/delayed-release-hpmc-capsules-for-efficient-delivery-of-cholecalciferol-solid-di 2026-04-28T04:57:27.452788+00:00 Delayed Release HPMC Capsules for Efficient Delivery of Cholecalciferol Solid Dispersion 2023-03-21 10.5530/ijper.57.2.51 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-408.pdf Introduction: The deficiency of Vitamin D is associated with an increased risk of various diseases and deficiency of this Vitamin is recognized in individuals all over the world. Therefore, the intake of Vitamin D has become essential. Objectives: Cholecalciferol (Vitamin D3) is a poorly soluble molecule and it is very sensitive to degradation under environmental factors such as light, temperature, and oxygen. Its stability is also affected adversely under acidic conditions. Therefore, solid dis Solid dispersion, Cholecalciferol, HPMC capsule, Caco-2 cells, Oral delivery, Dissolution https://www.ijper.org/berberine-suppresses-gestational-diabetes-in-streptozotocin-induced-diabetes-mel 2026-04-17T09:38:09.711311+00:00 Berberine Suppresses Gestational Diabetes in Streptozotocin-induced Diabetes Mellitus Rats by Suppression of Inflammatory Mediators 2023-03-21 10.5530/ijper.57.2.53 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-423.pdf Background: Gestational diabetes mellitus (GDM) is a serious health condition witnessed among females who experience insulin resistance and glucose intolerance with the onset of pregnancy. Multiple risk factors prevail both to the gestating mother and the growing fetus at the time of pregnancy which may prolong even postpartum. Aim: Berberine, a natural plant extract known for its anti-inflammatory and potent antidiabetic activity was used to clinically suppress the risk factors involved in Gest Gestational diabetes mellitus, Inflammation, Berberine, Antioxidant, Antidiabetic https://www.ijper.org/investigation-on-potential-of-karanjin-loaded-emulgel-for-improved-efficacy-agai 2026-04-17T09:38:12.27225+00:00 Investigation on Potential of Karanjin Loaded Emulgel for Improved Efficacy against Psoriasis 2023-03-21 10.5530/ijper.57.2.49 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-393.pdf Aim: The objective of this work was to prepare and characterize Karanjin loaded emulgel for enhanced effectiveness against psoriasis. Materials and Methods: Karanjin emulsion was prepared using peppermint oil and was loaded in gel base (carbopol 940 was used as gelling agent). Various batches of emulsion were prepared by varying concentration of tween 80 and were optimized for various parameters. Results: Optimized emulsion (KE5) gave droplet size of 110.4 ± 1.56 nm, -40.9 ± 1.11 mV zeta potenti Psoriasis, Emulgel, Karanjin, PASI Scoring, In vivo anti-psoriatic activity, Ex vivo permeation https://www.ijper.org/insight-into-the-glycosylation-methods-of-the-flavonoids-as-an-approach-to-enhan 2026-04-17T09:38:12.593945+00:00 Insight into the Glycosylation Methods of the Flavonoids as an Approach to Enhance its Bioavailability and Pharmacological Activities 2023-03-21 10.5530/ijper.57.2.45 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-354.pdf Background: Flavonoids are a kind of polyphenol having a diverse set of pharmacological applications, but their bioavailability is limited due to their poor stability, poor solubility, quick clearance, and low intrinsic characteristics. According to the prior study, the flavonoids containing the sugar moiety have better solubility and stability (for example rutin) as they maintain greater plasma levels and a longer mean residence duration than the flavonoids have no glycoside moiety. Aim: This r Flavonoids, Classification, Limitations, Bioavailability, Glycosylation https://www.ijper.org/new-eco-friendly-uv-spectroscopic-methods-for-simultaneous-assessment-of-dapagli 2026-04-28T05:08:16.988811+00:00 New Eco-friendly UV-spectroscopic Methods for Simultaneous Assessment of Dapagliflozin, Saxagliptin and Metformin in Ternary Mixture 2023-03-21 10.5530/ijper.57.2.69 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-559.pdf Background and Aim: Qternmet XR® consisting of dapagliflozin (10 mg), saxagliptin (5 mg), and metformin hydrochloride (1000 mg), is a fixed-dose combination (tablets) that improves glycemic control in individuals with diabetes mellitus (type 2). The projected work presents four spectrophotometric methods that are eco-friendly, quick, effortless, accurate and reproducible for the concurrent assessment of the ternary mixture. Materials and Methods: The 1st approach works on the notion of unravelli Dapagliflozin, Saxagliptin, Metformin, Simultaneous Equation Method, Ratio Difference Spectroscopic approach, Derivative Ratio Spectrum-Zero crossing approach, Double Divisor Ratio Spectra Derivative approach, Ternary mixture https://www.ijper.org/in-vitro-antibacterial-and-in-silico-evaluation-of-ficus-benghalensis-methanolic 2026-04-17T09:38:11.933789+00:00 In vitro Antibacterial and in silico Evaluation of Ficus benghalensis Methanolic Bark Extract, as Potential Anti-MRSA Agent 2023-03-21 10.5530/ijper.57.2.57 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-466.pdf Background: Methicillin-resistant Staphylococcus aureus (MRSA), known to be highly resistant bacterium, leading to dreadful infections with limited treatment options. Objectives: The current study mainly focused to investigate the anti-staphylococcal activity of Ficus benghalensis methanolic bark (FBMB) extract against Methicillin-resistant Staphylococcus aureus (MRSA). Materials and Methods: The assessment of Ficus benghalensis methanolic bark (FBMB) extract was performed by agar well diffusion MRSA, Ficus benghalensis, Bark extract, Anti-biofilm, Anti-virulence, Anti-bacterial, Membrane stability, in silico https://www.ijper.org/discrimination-of-different-part-of-curcuma-longa-by-hplc-fingerprints-combined 2026-04-28T05:09:22.078419+00:00 Discrimination of Different Part of Curcuma longa by HPLC Fingerprints Combined with Multivariate Statistical Analysis 2023-03-21 10.5530/ijper.57.2.71 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-583.pdf Aim: The purpose of this study is to develop a method to explore the difference between the rhizomes and tuberous roots of Curcuma longa, and screen out the difference markers. Materials and Methods: The quantitative analysis and fingerprints of rhizomes and tuberous roots were established by HPLC, rhizomes and tuberous roots of Curcuma longa were clearly discriminated by Hierarchical Cluster Analysis (HCA), Similarity Analysis (SA) and Principal Component Analysis (PCA). The difference markers Curcuma longa, Discrimination, HPLC fingerprints, Multivariate statistical analysis, Rhizomes and tuberous root https://www.ijper.org/clinical-pharmacist-led-approach-on-enhancement-of-medication-adherence-resolvin 2026-04-28T05:10:51.38252+00:00 Clinical Pharmacist Led Approach on Enhancement of Medication Adherence Resolving the Drug Related Problems with Selective Serotonin Reuptake Inhibitors among the Patients with Psychiatric Illness. A Prospective, Pre and Post Non-Randomised Interventional Study 2023-03-21 10.5530/ijper.57.2.75 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-612.pdf Introduction: Non-adherence is one of the most common barriers to the successful completion of treatment and it can be worst in psychiatric patients. Objectives: To assess, compare and resolve drug-related problems and medication adherence among psychiatric patients with SSRI and to assess the association between non-adherence and drug-related problems. Materials and Methods: In this prospective, non-randomized interventional study 90 psychiatry patients which were on SSRI treatment of both gend Medication adherence, Drug Related Problems, SSRI, Mood disorders, MARS https://www.ijper.org/chemometrics-assisted-spectrophotometric-method-development-and-validation-for-s 2026-04-28T05:09:01.110043+00:00 Chemometrics Assisted Spectrophotometric Method Development and Validation for Simultaneous Estimation of Abacavir, Lamivudine and Dolutegravir in Dosage Form 2023-03-21 10.5530/ijper.57.2.70 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-570.pdf Aim: Multivariate methods, particularly Classical Least Square, Inverse Least Square (ILS), Partial Least Square and Principal Component Regression are invented for the quantitation of the Abacavir sulphate (ABA), Lamivudine (LAM) and Dolutegravir sodium (DOL) in their combined tablet formulation. Materials and Methods: Chemometrics is the integration of statistical and mathematical approaches to analytical data in order to extract as much information as possible. The calibration and validation Abacavir sulphate, Lamivudine, Dolutegravir sodium, Chemometrics, Spectophotometric, Validation https://www.ijper.org/development-and-validation-of-uv-spectrophotometric-method-for-the-estimation-of 2026-04-28T05:09:58.27682+00:00 Development and Validation of UV-spectrophotometric Method for the Estimation of Wintergreen Oil in Pharmaceutical Formulation 2023-03-21 10.5530/ijper.57.2.72 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-591.pdf Objectives: The study aimed to develop and validate a simple UV-spectrophotometric method for quantifying Wintergreen oil in micro/nanosponges. Materials and Methods: The method was developed using acetonitrile as a solvent system and validated for various parameters such as linearity, precision, repeatability, the Limit of Detection (LOD), and the Limit of Quantification (LOQ), and accuracy according to ICH guidelines. Results: The oil showed an absorption maximum at 237nm. Linearity between co Wintergreen oil, UV-spectrophotometry, Validation, Micro/nanosponges, Pharmaceutical formulation https://www.ijper.org/application-of-the-case-teaching-method-in-a-pharmaceutical-analysis-online-cour 2026-04-17T09:38:14.320712+00:00 Application of the Case Teaching Method in a Pharmaceutical Analysis Online Course 2023-03-21 10.5530/ijper.57.2.47 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-377.pdf Objectives: To explore the teaching effect of integrating the case teaching method into an online course on pharmaceutical analysis. Materials and Methods: The case teaching method was adopted as the technique for delivering professional knowledge. The online course integrated knowledge teaching, practical ability, and value guidance. The effect of the case teaching method was evaluated by course assessment and a questionnaire. Results: After the reform, students’ online course examination score Case teaching method, Drug analysis, Online courses https://www.ijper.org/chemotherapy-induced-peripheral-neuropathy 2026-04-28T04:52:31.420628+00:00 Chemotherapy-Induced Peripheral Neuropathy 2023-03-21 10.5530/ijper.57.2.44 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-342.pdf Chemotherapy-induced peripheral neuropathy is a frequent and dose-limiting complication of chemotherapeutic drugs such as platinum-based compounds, taxanes, vinca alkaloids, bortezomib, and thalidomide that damages peripheral nerves and has a severe influence on patients' well-being and sickness outcomes. Manifestations of CIPN include numbness, tingling, neuropathic pain, cramping, and trouble handling small objects and walking. Recent research in the CIPN pathogenesis has revealed new strategi Chemotherapy-induced peripheral neuropathy, Mechanism of CIPN, Prophylactic and Therapeutic approaches of CIPN https://www.ijper.org/amruthmune-a-standardized-extract-comprises-of-tinosporin-from-tinospora-cordifo 2026-04-17T09:38:08.682072+00:00 AmruthMune, A Standardized Extract Comprises of Tinosporin from Tinospora cordifolia and its Mechanism of Immunostimulatory Activity 2023-03-21 10.5530/ijper.57.2.59 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-490.pdf Background: Tinospora cordifolia is an illustrious medicinal herb in Indian traditional ayurvedic medicine because of its substantial medicinal properties. It is reported that Tinospora cordifolia has been used to cure for many ailments by traditional medicinal practitioners. It is captivating that, in this contemporary world Tinospora cordifolia is being used to retain good immune health. Materials and Methods: The objective of this research is to demonstrate the immune enhancing activity of Am Immune modulation, Murine macrophages, Phagocytosis, ELISA, MAPK signalling, pathway https://www.ijper.org/impact-of-regulatory-policy-changes-on-generic-drug-prices-in-the-united-states 2026-04-28T05:12:02.665534+00:00 Impact of Regulatory Policy Changes on Generic Drug Prices in the United States 2023-03-21 10.5530/ijper.57.2.76 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-617.pdf Introduction: Generic Drug User Fee Act (GDUFA) was introduced in 2012 to bring more and more generic drugs into the market in a short time through an effective review process. In the present study, the impact of the GDUFA on prices of the generic drugs has been evaluated. Materials and Methods: Various research reports related to drug costs and competition such as (i) reasons for high drug prices, (ii) FDA’s research on drug prices pre- and post- GDUFA, and (iii) the current status of generic d Congressional Budget Office (CBO), Federal Trade Commission (FTC), Generic Drug User Fee Act (GDUFA), USFDA, Drug Prices https://www.ijper.org/orphan-drug-development-policies-in-india-and-the-united-states-a-comparison 2026-04-28T04:51:38.608118+00:00 Orphan Drug Development Policies in India and the United States: A Comparison 2023-03-21 10.5530/ijper.57.2.42 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-329.pdf Background: A pharmacological agent known as an orphan drug was created to address rare or orphan diseases. The Food and Drug Administration (FDA) claims that the Orphan Drug Act has certainly encouraged the development of treatments for rare diseases. The Orphan Drug Act was passed in the United States in 1983 to encourage pharmaceutical companies to develop treatments for rare diseases. Global sales of orphan drugs are anticipated to increase at a Compound Annual Growth Rate (CAGR) of 12.3% fr Orphan Drugs, Orphan diseases, Rare diseases, Initiative, Treatment https://www.ijper.org/nanostructured-lipid-carriers-in-chemotherapeutics-an-overview 2026-04-17T09:38:13.799662+00:00 Nanostructured Lipid Carriers in Chemotherapeutics: An Overview 2023-03-21 10.5530/ijper.57.2.40 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2-310.pdf Cancer is a life-threatening disease that is associated with persistent tissue injury and uncontrolled cell growth. The treatments available to treat cancer are chemotherapy, surgery and radiation therapy. These treatments are used in combinations, while the most preferred treatment is chemotherapy. Because of the Non-specificity of anticancer drugs, they kill normal healthy cells along with cancer cells which lead to severe side effects. To minimize such limitations associated with conventional Cancer, Nanostructured lipid carriers, Drug targeting, Lipids, Anticancer drugs https://www.ijper.org/berberine-hydrochloride-loaded-liposomes-gel-preparation-characterization-and-an 2026-04-28T04:22:13.219888+00:00 Berberine Hydrochloride-loaded Liposomes Gel: Preparation, Characterization and Antioxidant Activity 2023-01-17 10.5530/001954642087 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-074.pdf Aim: Berberine hydrochloride is a Traditional Chinese Medicine component with antibacterial, antiviral, anti-inflammatory, antioxidant and lowering blood sugar effects. However, the application of berberine hydrochloride has been hindered for a long time due to its poor solubility and low bioavailability. This study aims to design a liposomes-gel to enhance the bioavailability and antioxidant activity of berberine hydrochloride. Materials and Methods: The thin-film dispersion hydration method wa Berberine hydrochloride, Liposomes, Sodium alginate, Hydrogel, Antioxidant https://www.ijper.org/dipeptide-conjugates-an-important-class-of-therapeutic-agents 2026-04-28T04:17:04.663396+00:00 Dipeptide Conjugates: An Important Class of Therapeutic Agents 2023-01-17 10.5530/001954640093 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-015.pdf Dipeptide conjugates and conjugates of amino acids with heterocycles or other chemical entity are significant class of medicinal compounds with a wide range of biological actions including antibacterial, antiviral, anticancer, antimalarial, and immunomodulatory activity. Such conjugates demonstrated a wide range of applications in biology and are utilized in a number of fields including medicinal chemistry, material science etc. The several biological activities shown by these conjugates are enc Anticancer, Immunoactivators, Antivirals, Antimicrobials, Antimalarials https://www.ijper.org/terminalia-arjuna-bark-extract-reduces-high-fat-diet-induced-cardiac-damage-in-w 2026-04-17T09:38:15.851556+00:00 Terminalia arjuna Bark Extract Reduces High Fat Diet Induced Cardiac Damage in Wistar Rats by Altering Biochemical and Histological Parameters 2023-01-17 10.5530/001954641032 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-083.pdf Objectives: The aim of the present study was to examinethe protective effect of bark extract of TA (Terminalia arjuna) on HFD (high fat diet) induced biochemical and histopathological changes in Wistar rats. Materials and Methods: Group 1 – control rats received water ad libitum, Group 2 – HFD group received corn oil orally at a dose of 10mL/kg, Group 3 (HFD+ Atorvastatin (ATV) 10mg/kg), Group 4 (HFD+TA125 mg/kg), and Group 5 (HFD+TA250 mg/kg) were treated as indicated 6 days a week for 5 consec Terminalia arjuna, Histopathology, Atorvastatin, Lipid profile, LCAT enzyme, Rats https://www.ijper.org/flat-foot-and-associated-factors-among-university-students-aged-18-25-years-a-un 2026-04-17T09:38:16.683316+00:00 Flat Foot and Associated Factors among University Students Aged 18-25 Years: A University-Based Study 2023-01-17 10.5530/001954641962 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-295.pdf Background: In various human postural studies, foot is considered to be a rigid body. The flat foot, also referred to as the acquired disorder of the flat foot, results from the subsidence of the arches of the feet. Usually, in an upright position, the middle margin of the sole of the foot does not touch the ground. The condition of flatfoot can affect the healthy lifestyle and the weight management for an individual. But the burden of the flat foot in young adults is unknown. Aim: The objective Flatfoot, Staheli arch index, BMI, Footwear, Nationality https://www.ijper.org/phytochemical-analysis-and-in-vitro-cell-viability-effects-of-ethanolic-extract 2026-04-17T09:38:20.738563+00:00 Phytochemical Analysis and in vitro Cell Viability Effects of Ethanolic Extract of Ormocarpum cochinchinense on Mouse Embryonic Fibroblasts 2023-01-17 10.5530/001954641931 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-120.pdf Background: Ormocarpum cochinchinense is a medicinal herb known to be used by traditional bone setters for the healing of bone fractures. This herb has many active biomolecules, which are responsible for biological activities like antioxidant, anti-inflammatory, hepatoprotective and anticancer. This study aimed to perform phytochemical screening to identify the phytoconstituents and determine the cell viability effects of ethanolic extract of Ormocarpum cochinchinense through MTT assay. Material Ormocarpum cochinchinense, MTT assay, GC-MS, Phytocompounds https://www.ijper.org/validation-of-rapid-and-simple-hplc-uv-method-for-diflunisal-determination-in-bu 2026-04-17T09:38:15.678506+00:00 Validation of Rapid and Simple HPLC-UV Method for Diflunisal Determination in Bulk Drug and Human Plasma 2023-01-17 10.5530/001954641926 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-278.pdf Background: Transthyretin amyloidosis is a rare disease currently under wide investigation and many different therapeutic agents were developed for its control and treatment. In addition to the newly discovered drugs, it was also observed drug repurposing of some well-studied therapeutic agents. Diflunisal was developed in 1971 as an anti-inflammatory and analgesic drug but showed good results when used as a kinetic stabilizer of the transthyretin protein. Objectives: Present study describes a h Diflunisal, Bioanalysis, HPLC-UV, Validation https://www.ijper.org/neuroprotective-role-of-periplocin-against-aluminium-chloride-stimulated-alzheim 2026-04-17T09:38:15.512223+00:00 Neuroprotective Role of Periplocin Against Aluminium Chloride-stimulated Alzheimer’s Disease in a Rat Model by Modulation of Oxidative Stress and Inflammation 2023-01-17 10.5530/001954642194 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-147.pdf Background: Alzheimer’s disease is a prevalent neurodegenerative condition marked by the assembly of ß-amyloid deposits inside the brain parenchyma. Aluminium is a neurotoxin molecule that generates oxidative stress linked to various neurological disorders. Objectives: This study focused on the neuroprotective effects of periplocin, a natural compound, against aluminium chloride (AlCl3)-stimulated diseased rat model. Materials and Methods: Four groups of twenty-four Sprague Dawley rats were esta Periplocin, Alzheimer’s disease, Aluminium chloride, Neuroinflammation, Acetylcholinesterase https://www.ijper.org/comparative-extraction-and-quantification-of-scutellarein-from-leaves-of-triumfe 2026-04-28T04:23:28.476154+00:00 Comparative Extraction and Quantification of Scutellarein from Leaves of Triumfetta rhomboidea Using RP-HPLC 2023-01-17 10.5530/001954641137 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-101.pdf Aim: The purpose of this paper was to develop a sensitive, reproducible Reverse Phase High Performance Liquid Chromatography (RP-HPLC) for extraction and quantitative estimation of Scutellarein, major flavone glycoside from leaves of Triumfetta rhomboidea. Materials and Methods: To optimize best solvent system and ideal extraction methodology, various leaves extract was prepared by using different solvent systems such as ethanol, ethanol: water (50:50) and water through different extraction meth Triumfetta rhomboidea, Scutellarein, Accelerated Solvent extraction, Ultrasound Assisted Extraction, RP-HPLC https://www.ijper.org/visnagin-mitigates-glycerol-induced-acute-kidney-injury-in-rats-through-decreasi 2026-04-17T09:38:18.226646+00:00 Visnagin Mitigates Glycerol-induced Acute Kidney Injury in Rats through Decreasing Inflammation, Oxidative Stress, and Renal Dysfunction Markers 2023-01-17 10.5530/001954642201 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-134.pdf Background: Acute kidney injury (AKI) is a heterogenous condition, characterized by dysregulated kidney function along with reduced glomerular filtration, solute excretion, and urine output. Objectives: This work was focused to investigate the therapeutic roles of visnagin against the glycerol-induced AKI in rats via reducing the inflammation and oxidative stress responses. Materials and Methods: The AKI was induced in the Wistar rats by injecting 50% of glycerol (10 ml/kg). Then AKI rats were t Glycerol, Renal dysfunction, Creatinine, Inflammation, Visnagin, Rhabdomyolysis https://www.ijper.org/anxiolytic-potential-of-chloroform-extract-of-ziziphus-mauritiana-lam-leaves-in 2026-04-28T04:22:51.399542+00:00 Anxiolytic Potential of Chloroform Extract of Ziziphus mauritiana Lam. Leaves in Mice 2023-01-17 10.5530/001954641261 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-094.pdf Introduction: With a tremendous spike in the cases of anxiety in recent years, scientists are looking for herbal drug alternatives for its treatment as all the conventional medication options available in the market have side effects and lead to dependence. Ethnopharmacological reports revealed the usefulness of Ziziphus mauritiana Lam. for anxiety and depression. Therefore, it was envisaged to explore this plant’s possible anxiolytic activity. Objectives: The purpose of the present study was to Ziziphus mauritiana Lam., Chloroform extract, Anxiolytic, Triterpenoid, Molecular docking study https://www.ijper.org/selected-essential-oils-as-natural-ingredients-in-cosmetic-emulsions-development 2026-04-17T09:38:20.418386+00:00 Selected Essential Oils as Natural Ingredients in Cosmetic Emulsions: Development, Stability Testing and Antimicrobial Activity 2023-01-17 10.5530/001954642109 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-125.pdf Background: Essential oils are currently the subject of intensive scientific study, and their potential as active medicinal compounds or natural preservatives has attracted the attention of the cosmetic and pharmaceutical industries. Objectives: The objectives of the present study were: to develop a cosmetic emulsion based on different concentrations of synthetic preservative and essential oils, applied as natural preservatives; to evaluate and subsequently compare their stability and antimicrob Cosmetic emulsion, Essential oils, Methylparaben, Formulation, Stability testing, Self-preserving activity https://www.ijper.org/antifungal-activity-of-cymbopogon-flexuosus-essential-oil-and-its-effect-on-biof 2026-04-17T09:38:15.334388+00:00 Antifungal Activity of Cymbopogon flexuosus Essential Oil and its Effect on Biofilm Formed by Candida parapsilosis and Candida tropicalis on Polystyrene and Polyvinyl Plastic Surfaces 2023-01-17 10.5530/001954641705 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-113.pdf Aim: To determine the antifungal and antibiofilm activity of Cymbopogon flexuosus (Lemongrass oil) against C. parapsilosis and C. tropicalis. Materials and Methods: Lemongrass oil, was analyzed by GC-MS. Antifungal activities, minimum inhibitory concentration, and minimum fungicidal concentration against C. parapsilosis and C. tropicalis were determined. The effect of LGO inhibiting biofilm formation by these Candida species on different surfaces was evaluated. Cytotoxicity of Cymbopogon flexuos Antifungal, Antibiofilm, Candida tropicalis, Candida parapsilosis, Cymbopogon flexuosus https://www.ijper.org/derivative-spectrophotometric-method-development-and-validation-for-the-estimati 2026-04-17T09:38:19.057184+00:00 Derivative Spectrophotometric Method Development and Validation for the Estimation of Evogliptin Tartrate in Pharmaceutical Dosage Form 2023-01-17 10.5530/001954640245 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-228.pdf Aim: A simple and economic method was developed as a derivative spectrophotometric study for estimation of evogliptin tartrate in the tablet dosage form. The developed derivative method was validated as per the ICH guideline. Materials and Methods: The maximum absorption of evogliptin tartare was found to be 267 nm and its first and second derivative wavelengths were measured at 275 nm and 277 nm respectively. Water was used as a solvent for all measurements. Results: The developed method was sh Derivative method, Evogliptin tartrate (EVO), First derivative, Spectroscopy method, UV-visible method, Validation https://www.ijper.org/design-synthesis-characterization-and-anti-cancer-activity-evaluation-of-novel-t 2026-04-17T09:38:15.006392+00:00 Design, Synthesis, Characterization, and Anti-Cancer Activity Evaluation of Novel Thiosemicarbazide Analogs 2023-01-17 10.5530/001954641768 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-210.pdf Aim/Background: Across the world disease of cancer is one of the factors of death and to identify the emerging role of thiosemicarbazide analogs for the cancer disease it was decided to design, and synthesize novel thiosemicarbazide derivatives (5a-i) with in-vitro anticancer activity evaluation. Materials and Methods: Substituted benzoic acid, thionyl chloride, hydrazine hydrate, and ammonium thiocyanate were used to create a new series of thiosemicarbazide derivatives (5a-i). The final derivat Anticancer, B16F10 cell line, Melanoma, Thiosemicarbazide, MTT assay https://www.ijper.org/formulation-and-evaluation-of-nanosponges-loaded-hydrogel-of-metformin-hydrochlo 2026-04-17T09:38:16.517214+00:00 Formulation and Evaluation of Nanosponges Loaded Hydrogel of Metformin Hydrochloride 2023-01-17 10.5530/001954641980 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-053.pdf Objectives: The objective of the research is to formulate a nanosponges loaded hydrogel of Metformin Hydrochloride for the treatment of Psoriasis. Psoriasis is currently treated with a variety of topical and systemic therapies. Many of these treatments, however, are expensive and involve side effects, such as immunosuppression. As a result, there is a need to develop therapies that are effective, have fewer adverse effects, and are less expensive. Materials and Methods: The Solvent Emulsion Diff Nanosponges, Metformin Hydrochloride, Topical Drug Delivery, Hydrogel, Psoriasis https://www.ijper.org/investigation-of-cardioprotective-effect-of-2-4-thiazolidinedione-derivative-usi 2026-04-17T09:38:16.856166+00:00 Investigation of Cardioprotective Effect of 2, 4-thiazolidinedione Derivative Using HFD-STZ Fed Rats 2023-01-17 10.5530/001954640215 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-173.pdf Background: Myocardial infarction is a 2nd most important origin of universal death and after coronary revascularization, cardiovascular events occurs further a lot in subjects through DM: 3.5- as well as 2-fold fatality ranks correspondingly behind percutaneous coronary intervention or coronary bypass graft surgery. Objectives: The aim of an attendance research was to discover usefulness of 2, 4- thiazolidinedione derivatives lying on diabetic MI and HFD-STZ diabetic rats. Materials and Methods 2, 4-Thiazolidinedione, Myocardial infarction, Diabetic MI, Type-2 diabetes, LAD, Macrovascular complication https://www.ijper.org/development-and-validation-of-chemometric-assisted-uv-methods-for-the-simultaneo 2026-04-28T04:34:08.00856+00:00 Development and Validation of Chemometric Assisted UV Methods for the Simultaneous Determination of Ambroxol Hydrochloride, Terbutaline Sulphate and Guaiphenesin in Pharmaceutical Dosage Form 2023-01-17 10.5530/001954641128 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-242.pdf Aim: The present study aimed to develop and validate chemometric assisted UV spectrophotometric methods for the simultaneous determination of ambroxol hydrochloride (ABH), terbutaline sulphate (TES) and guaiphenesin (GPN) in their combined dosage form. Materials and Methods: The two chemometric models applied for the UV spectroscopic data were principal component regression (PCR) and partial least squares regression (PLS). Standard mixture solutions containing different ratios of ABH, TES and GP Chemometric models, Principal component regression, Partial least squares regression, Ambroxol hydrochloride, Terbutaline sulphate, Guaiphenesin https://www.ijper.org/methylmercury-mn2-and-pb2-exposure-promotes-premature-proliferationdifferentiati 2026-04-17T09:38:18.741786+00:00 Methylmercury, Mn2+ and Pb2+ Exposure Promotes Premature Proliferation/Differentiation of Human Neural Stem Cells in Different Ways 2023-01-17 10.5530/001954641252 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-155.pdf Background: Methylmercury (MeHg), manganese ions (Mn2+), and lead ions (Pb2+) are ubiquitous environmental pollutants and may be neurotoxic especially during fetal development. We decided to explore the toxic mechanisms of MeHg (organic heavy metals), Mn2+ (inorganic heavy metals) and Mn2+ on the proliferation and differentiation of human neural stem cells (hNSCs). Materials and Methods: The proliferation and apoptosis of hNSCs were analyzed via CCK-8 method and flow cytometry under MeHg, Mn2+ a Methylmercury, Manganese ion, Lead ion, Neural stem cells, Cell differentiation https://www.ijper.org/pros-and-cons-of-animal-models-special-emphasis-on-anti-arthritic-clinical-evalu 2026-04-17T09:38:17.186754+00:00 Pros and Cons of Animal Models: Special Emphasis on Anti-arthritic Clinical Evaluation Model 2023-01-17 10.5530/001954641253 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-022.pdf Introduction: Generally, animal models are regarded as very useful tools for studying pathophysiology and the clinical aspects of the disease and are always used as the first step for investigating a prospective new therapy. On the other hand, these models have numerous distinctions from the human condition by numerous constraints such as cost, animal size, and accessibility. Objectives: Nevertheless, scientists keep on depending on creature models because of the way that they can be promptly te Animal Model, Human Condition, Critics, Arthritis model, in vivo model, in vitro model, Biomedical examination https://www.ijper.org/troxerutin-a-bioflavonoid-exhibits-oxidative-stress-induced-cytotoxic-effects-on 2026-04-17T09:38:18.897006+00:00 Troxerutin, a Bioflavonoid Exhibits Oxidative Stress-induced Cytotoxic Effects on KB Cells 2023-01-17 10.5530/001954642011 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-167.pdf Background: The prevalence of oral cancer is high and it is the sixth most occurring cancer in the world. Some of the drugs used to treat oral cancer cause adverse effects and are resistant to treatment. Objectives: This study was designed and performed to evaluate the cytotoxic and anti-cancerous effects of troxerutin. Materials and Methods: Cell proliferation, cell viability, and morphological analysis were performed with different doses of troxerutin. Once the IC50 value was obtained, doses w Oral cancer, Troxerutin, Nitric oxide, Oxidative stress, Anti-cancer, Chemotherapy https://www.ijper.org/a-case-for-chirality-chiralpediacom 2026-04-28T04:38:45.536903+00:00 A Case for Chirality - chiralpedia.com 2023-01-17 10.5530/001954640002 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-308.pdf The Pharmacy degree course curriculum marks the most crucial stage of conventional pedagogy because specialized discipline-based, content-oriented courses in pharmaceutical and allied areas of knowledge are introduced at this juncture. Students reach this stage after learning chemistry for 12 years of general education, to pursue their careers in pharmaceutical sciences and other allied areas enabled by it. To say that pharmaceutical science is a domain enabled by applied chemistry is an underst Letter to the Editor https://www.ijper.org/qsar-and-molecular-docking-studies-of-5-benzylideno-2-adamantylthiazol32-b124tri 2026-04-28T04:30:29.081846+00:00 QSAR and Molecular Docking Studies of 5-benzylideno-2-adamantylthiazol[3,2-b][1,2,4]triazol-6(5H)ones Derivatives as Antimicrobial Activity 2023-01-17 10.5530/001954641712 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-194.pdf Aim and Background: Bacterial Infection is a leading cause of death worldwide. Triazoles and thiazolinones (fused) have been reported to possess many biological activities including antibacterial activity. To study 2D and 3D QSAR followed by Molecular Docking studies to generate new chemical entities (NCE’s) containing as pharmacophore for antibacterial activity. Materials and Methods: In the presented studies we have reported the results of QSAR studies for the 21 derivatives of triazole-thiaz Triazole-thiazolinone, Antibacterial, QSAR, Combilib, Docking, Molecular modelling studies https://www.ijper.org/area-under-curve-method-for-the-simultaneous-quantitative-estimation-of-pravasta 2026-04-17T09:38:19.381257+00:00 Area under Curve Method for the Simultaneous Quantitative Estimation of Pravastatin Sodium and Aspirin 2023-01-17 10.5530/001954640307 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-234.pdf In the present study an economic, a precise UV-spectrosphotometric method for estimating Aspirin and Pravastatin sodium in bulk and physical mixture is carried out as there is less paucity of literature on simultaneous estimation of these drugs by area under curve method. 0.1M sodium hydroxide is used as a solvent in the estimation. The method determines Pravastatin sodium and Aspirin at the wavelength range of 292-302 nm and 233-243 nm respectively. Beer’s range was observed at 5-45 μg/mL for A Pravastatin sodium, Aspirin, Area under the curve, 0.1M Sodium hydroxide, Physical mixture, Recovery studies https://www.ijper.org/synthesis-anticonvulsant-and-molecular-docking-studies-of-35-disubstituted-45-di 2026-04-17T09:38:17.706796+00:00 Synthesis, Anticonvulsant, and Molecular Docking Studies of (3,5-disubstituted-4,5-dihydro-1H-pyrazol-1-yl) (4-chlorophenyl) Methanone Derivatives 2023-01-17 10.5530/001954641727 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-202.pdf Aim/Background: This research work aims to design and synthesize novel compounds containing pyrazoline moiety in their structure with enhanced anticonvulsant activity in comparison with the standard (Phenytoin) drug. In the docking study, the target protein with the active site of human mitochondrial branched-chain aminotransferase (BCATm) (PDB ID: 2A1H) was used against synthesized compounds. Hence the importance of the pyrazoline compounds is thought of as interest for developing a new compoun Anticonvulsant, Docking, Pyrazoline, ScPTZ, Phenytoin https://www.ijper.org/monitoring-of-defense-enzymes-phenylalanine-ammonia-lyase-and-peroxidase-in-magn 2026-04-17T09:38:18.393266+00:00 Monitoring of Defense Enzymes (Phenylalanine Ammonia Lyase and Peroxidase) in Magnaporthe oryzae Infected Leaves after Treatment with Green Synthesized Silver Nanoparticles 2023-01-17 10.5530/001954642708 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-141.pdf Objectives: In this study, we focus on the amount of the two defence enzymes phenylalanine ammonia-lyase (PAL) and peroxidase (POX) expressed with regard to the treatment of green synthesized silver nanoparticles. Materials and Methods: The leaf blades were infected with Fungal spores and silver nanoparticles by spraying, and following infection, we estimated the enzyme activity of PAL and POX. The PAL activity is considered by using cinnamic acid as a standard. Results: Our results showed both Magnaporthe oryzae, PAL, POX, Silver Nanoparticles, Defense enzymes https://www.ijper.org/linalol-and-linalyl-acetate-quantitation-in-the-essential-oil-of-somatic-embryos 2026-04-17T09:38:20.912828+00:00 Linalol and Linalyl Acetate Quantitation in the Essential Oil of Somatic Embryos of Bursera linanoe R. 2023-01-17 10.5530/001954641346 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-107.pdf Introduction: Mexican artisans use the linaloe tree for the production of handcrafts. The extracted oil from the endangered Mexican tree Bursera linanoe which main components are the terpenes linalol and linalyl acetate is protected because of its excessive exploitation. An alternative to mitigate the deforestation of the linaloe tree is the use of somatic embryos, which can be cultured in vitro. Objectives: In this study, we quantify the yield of linaloe oil extracted from three different linal Bursera linanoe R., Linaloe oil, Extraction, Secondary metabolites, Microwaving, Bioreactors https://www.ijper.org/the-effect-of-antioxidants-and-cardiovascular-drugs-in-the-treatment-of-cardiac 2026-04-28T04:16:43.942145+00:00 The Effect of Antioxidants and Cardiovascular Drugs in the Treatment of Cardiac Diseases 2023-01-17 10.5530/001954642291 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-001.pdf Background: Reactive oxygen species mediate oxidative stress, is one of the major causes of the athero-thrombotic process involved in the etiology of peripheral arterial disease, ischemic strokes, and heart attack. Angiotensin-1 receptor blockers, betablockers, angiotensin-converting enzyme inhibitors, diuretics, calcium channel blockers are traditional cardio-protective drugs. But the problem associated with these medications is, a person diagnosed with high blood pressure in younger age, has t Cardiovascular diseases, Oxidative stress, Reactive oxygen species, Antioxidants, AT1 receptor blocker https://www.ijper.org/exploration-of-project-and-module-based-teaching-method-in-pharmaceutical-microb 2026-04-28T04:18:19.409583+00:00 Exploration of Project and Module-based Teaching Method in Pharmaceutical Microbiology Laboratory Courses for Undergraduate Pharmacy Students 2023-01-17 10.5530/001954641319 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-028.pdf Background: Pharmaceutical microbiology is an important applied branch of microbiology and it’s provided broad knowledge and understanding with regards to the principles, techniques and processes involved in pharmaceutical microbiological experiments. Objectives: To help students develop abilities related to laboratory techniques, data analysis, and systematic thought in biology, we have designed an exploratory program that employs project and the module-based teaching (PMBT) method. Materials a Pharmaceutical microbiology, Innovative learning, Project and module-based experiment, Experimental and practice teaching reform, Research https://www.ijper.org/optimization-of-fast-dissolving-tablets-of-ledipasvir-sofosbuvir-inclusion-compl 2026-04-28T04:19:17.57343+00:00 Optimization of Fast-dissolving Tablets of Ledipasvir-sofosbuvir Inclusion Complexes by Design of Experiments 2023-01-17 10.5530/001954641530 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-033.pdf Background: Fast-dissolving tablets (FDTs) were aimed to be developed for the latest approved combination drugs for Hepatitis-C treatment, Ledipasvir (LDV) and sofosbuvir (SBV) which suffered with poor water solubility. Materials and Methods: Cyclodextrin (CD) complexation was done for the drugs to improve their solubility. The optimized CD complexes were taken for developing FDTs to improve dissolution limited bioavailability of these drugs. FDTs were developed by adopting design of experiments Fast dissolving tablets, Hepatitis-C, Ledipasvir, Sofosbuvir, Optimization https://www.ijper.org/assessment-of-mucoadhesion-potential-of-thiolated-pectin-extracted-from-citrus-l 2026-04-28T04:19:42.053528+00:00 Assessment of Mucoadhesion Potential of Thiolated Pectin Extracted from Citrus limon 2023-01-17 10.5530/001954640001 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-045.pdf Aim: This study aimed to extract pectin from Citrus limon, synthesize thiolated pectin (TFP), and assess its mucoadhesion capability utilizing in-vitro and ex-vivo methodologies. Materials and Methods: Wilhelmy`s approach, the falling sphere method, the modified physical balancing method, and others were used to measure the mucoadhesion force of pectin and TFP and compared with chitosan (CS) and sodium carboxymethylcellulose (SCMC). Results: FTIR spectra containing carboxyl and hydroxyl groups c Mucoadhesion, Pectin, Thiolation, Chitosan, Sodium Carboxymethylcellulose https://www.ijper.org/statistically-optimized-facile-development-characterization-and-evaluation-of-ni 2026-04-28T04:21:18.27832+00:00 Statistically Optimized Facile Development, Characterization and Evaluation of Niosomal Nasal Drug Delivery System of Ropinirole Hydrochloride: In vitro Drug Release, Cytotoxicity and ex vivo Permeability Studies 2023-01-17 10.5530/001954641874 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-062.pdf Introduction: Nasal route is an alluring route for direct drug delivery to the central nervous system (CNS), owing to its avoidance of the hepatic first-pass metabolism and deciphering the blood–brain barrier passage issues. ROP-HCl has a lower experimental BBB permeability therefore ROP-HCl freighted niosomes were fabricated by ethanol injection method and served two purposes one being a novel Niosomal formulation impacting the permeability and other obtaining a sustained release property which Ropinirole hydrochloride, Statistical approach, Niosomes, Nasal drug delivery, cytotoxicity, Release kinetics, Ex-vivo permeability, Toxicity study https://www.ijper.org/piperine-induces-cell-death-apoptosis-and-inhibits-migration-in-cholangiocarcino 2026-04-28T04:28:25.963231+00:00 Piperine Induces Cell Death, Apoptosis and Inhibits Migration in Cholangiocarcinoma Cells 2023-01-17 10.5530/001954641324 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-161.pdf Background/Aim: Piperine (Pip) is an alkaloid that found from natural products and it has been reported to exert anticancer activities. Nevertheless, its anticancer effect has not yet been illustrated in cholangiocarcinoma (CCA) cells. In this work will be explored the Pip effects on two CCA cells and studied the underlying molecular mechanism. Materials and Methods: The KKU-100 and KKU-M452 cells proliferation were detected by sulforhodamine B assay, colony formation, and flow cytometric method Piperine, Apoptosis, Migration, Cholangiocarcinoma cells, Mitochondrial function, Reactive oxygen species production https://www.ijper.org/simultaneous-estimation-of-atovaquone-and-mefloquine-hydrochloride-qbd-based-met 2026-04-28T04:35:01.983156+00:00 Simultaneous Estimation of Atovaquone and Mefloquine Hydrochloride: QbD based Method Development and Validation 2023-01-17 10.5530/001954641318 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-250.pdf Background: Atovaquone are important drugs that are used in the treatment of malaria and in combination with mefloquine hydrochloride increases the efficacy and potency. Present study covers the development of UV-spectrophotometry based analytical techniques for the simultaneous estimation of mefloquine HCl and atovaquone employing the Quality by Design (QbD) methods. Materials and Methods: C-N-X method were employed for risk assessment study and Ishikawa fishbone diagram was plotted for underst Accuracy, Analytical Method Development, ICH Q2 guidelines, Precision, Quality by Design, Risk Assessment https://www.ijper.org/drug-repurposing-policies-and-statutes-lessons-from-the-covid-19-pandemic-a-revi 2026-04-28T04:38:13.313029+00:00 “Drug Repurposing” Policies and Statutes: Lessons from the COVID-19 Pandemic: A Review 2023-01-17 10.5530/001954641939 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-301.pdf Introduction: Repurposed drugs are not eligible for patent protection in India vide Sec 3 (d) of the Indian Patent Act, 1970. The data generated to establish the therapeutic efficacy of the repurposed drugs for the new indication are not eligible for data exclusivity under the provisions of the Drugs and Cosmetic Act, 1940. However, repurposed drugs possess immense advantages, especially when compared to the traditional route of drug discovery. Marketing repurposed drugs is fraught with challeng Repurposing drugs, Patents, Data exclusivity, COVID-19, Drug discovery, Drug development in India https://www.ijper.org/discovery-of-a-novel-synthetic-thiazole-benzimidazole-conjugate-that-acts-as-a-p 2026-04-17T09:38:18.052465+00:00 Discovery of A Novel Synthetic Thiazole-benzimidazole Conjugate that Acts as a Potent Pancreatic Lipase Inhibitor using in silico and in vitro Approaches 2023-01-17 10.5530/001954642131 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-218.pdf Aim/ Background: Pancreatic lipase (PL) inhibition has been suggested to be an effective method for obesity management. In this study, 10 novel thiazole-benzimidazole conjugates were designed. Materials and Methods: Conjugates were initially screened via in silico experiments, such as ADMET analysis and molecular docking, to identify the most promising PL inhibitors. Results: Results revealed that compounds 3, 6 and 8 had the most optimum drug likeness properties, and the highest binding affinit Pancreatic lipase, Inhibition, Thiazole-benzimidazole, in silico, in vitro, Enzyme assay https://www.ijper.org/a-new-stability-indicating-hplc-pda-method-for-estimation-of-eluxadoline-in-pres 2026-04-17T09:38:19.899129+00:00 A New Stability Indicating HPLC-PDA Method for Estimation of Eluxadoline in Presence of its Degradation Products 2023-01-17 10.5530/0019546402522 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-264.pdf Background: The goal of proposed study was to optimize and validate reversed phase high performance liquid chromatography (RP-HPLC) method for assessment of eluxadoline in presence of its forced degradation products in in-house tablet mixture. Materials and Methods: RP-HPLC method was developed using SunQSil C18 (250 mm × 4.6 mm, 5 μm) as stationary phase and 20 mM sodium acetate: methanol (45:55, v/v) as mobile phase at a 1 ml/min flow rate with 205 nm detection wavelength. The method was found Eluxadoline, Degradation studies, HPLC, Stability indicating method, Validation https://www.ijper.org/design-synthesis-and-molecular-docking-studies-of-s-1-2-substituted-benzylamino 2026-04-17T09:38:19.224017+00:00 Design, Synthesis and Molecular Docking Studies of (S)-1-(2-(substituted benzylamino)-3-methylbutanoyl)pyrrolidin-2-one analogues as GABA Mediated Anticonvulsant Agents 2023-01-17 10.5530/001954641726 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-182.pdf Background: Epilepsy is a deep rooted, partially curable brain illness that affects all individuals irrespective of ages and genders. Despite the discovery of various innovative antiepileptic drugs (AEDs), selectivity and toxicity issues remain. Materials and Methods: A series of (S)-1-(2-(substituted benzylamino)-3-methylbutanoyl)pyrrolidin-2-one analogues (5a-r) were synthesized and evaluated for their anticonvulsant activity. The analogues were screened by two gold standard methods, i.e., ele Pyrrolidine, Anticonvulsant activity, Molecular Docking, GABA-A, Toxicity, ADME prediction https://www.ijper.org/development-and-validation-of-highly-precise-methods-for-the-spectrophotometric 2026-04-28T04:36:20.924541+00:00 Development and Validation of Highly Precise Methods for the Spectrophotometric Determination of Cefpirome in Pharmaceutical Dosage Forms 2023-01-17 10.5530/001954640247 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-271.pdf Aim: Cefpirome (CFP) in pure and pharmaceutical dosage forms determination by spectrophotometer; two very sensitive techniques have been developed. Materials and Methods: By mixing alkaline β-Naphthol (2-NPL) with diazotized cefpirome drug, we get the pink colour at λmax 544 nm in procedure I. Drug undergoes oxidation by ferric ion followed by complex formation with 2,2’bipyridine (2,2’BPD) to obtain a blood red colour at λmax 520 nm in procedure II. Under ideal conditions, the goal is to maximi Accuracy, Cefpirome, Chromogen, Diazotization, Formulation, Oxidation https://www.ijper.org/implementation-of-telepharmacy-services-in-community-pharmacy-pharmacists-perspe 2026-04-28T04:37:26.198047+00:00 Implementation of Telepharmacy Services in Community Pharmacy – Pharmacists’ Perspective in Republic of Serbia 2023-01-17 10.5530/001954641895 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-1-286.pdf Aim/Background: COVID-19 pandemic has casted a new light over the capacity of telepharmacy to increase access to pharmaceutical care, providing more support to patients and allowing new opportunities for pharmacists. However, telepharmacy still hasn’t been introduced as a standardised pharmaceutical service in the Republic of Serbia, therefore, the objective of this paper is to assess the potential for its local implementation by exploring the perspectives of community pharmacists. Materials and Telehealth, Telemedicine, Pharmaceutical care, Pharmacy services, Public health https://www.ijper.org/bioprospecting-of-actinomycetes-from-diverse-ecosystems-for-antimicrobial-activi 2026-04-28T06:26:18.642506+00:00 Bioprospecting of Actinomycetes from Diverse Ecosystems for Antimicrobial Activity 2023-01-01 10.5530/ijper.57.3s.68 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-599.pdf Background: Actinomycetes are unique and ubiquitous organisms in nature and are historically holding first position as one of the major antibiotic producers. The aim of the study was screening and pre-treatments of soil, marine, and mangrove samples for isolation of antibiotic producing actinomycetes. Materials and Methods: Actinomycetes were isolated from pre-treated soil, marine, and mangrove samples using different isolation media. They were assessed for antimicrobial activity by cross streak Actinomycetes, Bioactive Metabolites, Biodiversity, Marine ecosystems, Antimicrobial activity, 16S rRNA https://www.ijper.org/formulation-and-characterization-of-inter-penetrating-network-of-isabgol-husk-mu 2026-04-28T05:40:37.271954+00:00 Formulation and Characterization of Inter-Penetrating Network of Isabgol Husk Mucilage for Modified Release of Diclofenac Sodium 2023-01-01 10.5530/ijper.57.3.85 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-703.pdf Introduction: Diclofenac Sodium (DS), a Non-Steroidal Anti-Inflammatory Drug (NSAID) is widely used in inflammation and pain management. However, the drug has a short half-life of 1.2-2 hr therefore, frequent administration of DS is required. In this research paper Inter-Penetrating Network (IPN) microspheres of Diclofenac sodium were made using Isabgol husk mucilage and Polyvinyl Alcohol (PVA) to prolong the release of diclofenac sodium. Isabgol husk is widely explored as a natural, economical, Inter-Penetrating Network, Isabgol husk mucilage, Diclofenac Sodium, DL-glyceraldehyde, Polyvinyl Alcohol https://www.ijper.org/impact-of-educational-programs-on-the-knowledge-and-attitude-of-healthcare-profe 2026-04-28T05:59:36.346081+00:00 Impact of Educational Programs on the Knowledge and Attitude of Healthcare Professionals in Antimicrobial Stewardship 2023-01-01 10.5530/ijper.57.3.108 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-898.pdf Introduction: The main concern related to antimicrobial use is the increasing incidence of resistance. Objective: This study aims to assess the impact of educational programs on the knowledge, attitudes, and practices of healthcare providers concerning antimicrobial Stewardship (AMS) in hospitals. Materials and Methods: This is a quasi-experimental study with one group pretest-posttest design. Health professionals were requested to complete an online questionnaire before and after educational pr Education, Antimicrobial stewardship, Knowledge, Attitude, Healthcare professional https://www.ijper.org/syringodium-isoetifolium-fosters-an-antioxidant-defense-system-modulates-glycoly 2026-04-28T06:29:18.197586+00:00 Syringodium isoetifolium Fosters an Antioxidant Defense System, Modulates Glycolytic Enzymes and Protects Membrane Integrity in DEN-induced Hepatocellular Carcinoma in Albino Wistar Rats 2023-01-01 10.5530/ijper.57.3s.78 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-690.pdf Background: Syringodium isoetifolium seagrass has bioactive constituents with potential pharmacological uses, but their use is limited. Materials and methods: Wistar albino rats were split into five groups. Except for group I, remaining all received DEN and Phenobarbitone. Extracts were administered to group III and IV orally with the dose of 250 and 500 mg/kg. 5 fluorouracil 20mg/kg was the standard. Results: The findings show that Syringodium isoetifolium significantly reduces liver tumor volu Syringodium isoetifolium, Wistar albino rats, Hepatocellular carcinoma https://www.ijper.org/gc-ms-analysis-and-antiproliferative-effect-of-ethanolic-extract-of-apium-graveo 2026-04-28T05:44:38.401249+00:00 GC-MS Analysis and Antiproliferative Effect of Ethanolic Extract of Apium graveolens L. seeds on MCF-7 Human Breast Cancer Cell Lines 2023-01-01 10.5530/ijper.57.3.90 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-742.pdf Objectives: The aim of this study was to identify main phytocompounds and to evaluate the antiproliferative effect of the ethanolic extract of Apium graveolens seeds. Materials and Methods: in vitro antiproliferative study of A. graveolens ethanolic extract was investigated against MCF-7 cells breast cancer cell lines using the MTT colorimetric assay. Further, the main bioactive components were elucidated by Gas Chromatography–Mass Spectrometry (GC–MS). Commercial mass spectral library was used Apium graveolens, GC-MS, Structural Elucidation, Phytocomponents, MCF-7, Antiproliferative https://www.ijper.org/different-innovative-uv-spectroscopic-approaches-for-simultaneous-assessment-of 2026-04-28T06:35:02.666096+00:00 Different Innovative UV-spectroscopic Approaches for Simultaneous Assessment of Celecoxib and Tramadol Hydrochloride in Binary Mixture 2023-01-01 10.5530/ijper.57.3s.89 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-787.pdf Background and Aim: Tablets containing celecoxib and tramadol hydrochloride that are sold under the brand name Seglentis® have given approval by the “Food and Drug Administration” (FDA) for the treatment of adults suffering from acute pain. Simultaneous assessment of celecoxib and tramadol hydrochloride in synthetic mixture was performed by five new UV-spectrophotometric approaches. Materials and Methods: The quantification of proposed medication was performed using the simultaneous equation app Celecoxib, Tramadol hydrochloride, Simultaneous equation, Dual wavelength, First derivative zero crossing, Ratio difference and the First derivative of ratio spectra spectroscopic methods, Binary mixture https://www.ijper.org/emerging-applications-of-electrospun-nanofibers-using-various-fabrication-techni 2026-04-28T05:37:54.750906+00:00 Emerging Applications of Electrospun Nanofibers Using Various Fabrication Techniques 2023-01-01 10.5530/ijper.57.3.80 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-658.pdf Nanofibers are fibers having nanometric diameters, made from a variety of polymeric materials, generally developed using electrospinning methods. It can incorporate multiple drugs, such as proteins, peptides, antibodies, and small molecules, either loaded inside or adhered to the surface. They offer enormous potential in the biomedical field, including drug delivery, regenerative medicine, stent coating, implants, and controlled drug release. The application of nanofibers in tissue regeneration Electrospun nanofiber, Self-assembly, Template synthesis, Tissue engineering, Scaffold https://www.ijper.org/inhalable-microparticulate-system-for-tuberculosis-an-updated-review 2026-04-28T05:37:38.189137+00:00 Inhalable Microparticulate System for Tuberculosis: An Updated Review 2023-01-01 10.5530/ijper.57.3.78 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-640.pdf Antibiotic efficiency declines in TB treatment and bacteria develop resistance over time due to numerous barriers such as lung mucus and biofilms surrounding the microbe. To tackle drug-resistant tuberculosis, there is a critical need for the discovery of novel medications and the repurposing of existing drugs with new mechanisms of action. Despite these challenges Vascular drug delivery shows promise as a potential treatment option for tuberculosis due to its ability to achieve high medicine le Mycobacterium tuberculosis (MTB), Inhalable Microparticles (MP), Multidrug-Resistant Tuberculosis (MDR-TB), Aspect Ratio (AR), Metered Dose Inhalers (MDI) https://www.ijper.org/doxorubicin-induced-chronic-heart-failure-is-alleviated-by-gentiopicroside-by-in 2026-04-17T09:38:23.552391+00:00 Doxorubicin-induced Chronic Heart Failure is Alleviated by Gentiopicroside by Inhibiting Oxidative Stress and Inflammation 2023-01-01 10.5530/ijper.57.3.107 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-890.pdf Aim/Background: To study the Oxidative stress and inflammation inhibited by Gentiopicroside in chronic heart failure induced by doxorubicin. Materials and Methods: The procured healthy rats were first divided into four groups group I was maintained as healthy control and the others were subjected to the induction of doxorubicin-induced chronic heart failure (Dox-CHF) by2.5 mg/kg/day DOX by i.p. on alternate days for 2 weeks. Then the Dox-CHF rats were further divided into three groups, group II Gentiopicroside, Doxorubicin, Cardiotoxicity, Oxidative stress, Anti-inflammatory https://www.ijper.org/article/57/3s/s724-s733 2026-04-28T06:31:46.474315+00:00 Isolation and Functioning Investigation of Salvia hispanica Seed Mucilage as a Potential Sustained Release Carrier for Water Soluble Drug 2023-01-01 10.5530/ijper.57.3s.82 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-724.pdf Background: Natural biopolymers or hydrogels are explored to sustain release of water-soluble drugs. Materials and Methods: Mucilage was isolated from Salvia hispanica seeds. Gelispheres loaded with Losartan Potassium (LP) were prepared using sodium alginate, pectin and CSM. Results: Isolated mucilage possesses immense properties like consistency and excellent hydration. Developed gelispheres exhibited good mucoadhesion and sustained drug release. Conclusion: Findings advocate the use of mucilag Chia seed mucilage, Gelisphere, Mucoadhesion https://www.ijper.org/effect-of-topiramate-on-mitochondrial-biogenesis-and-neuroinflammation-in-chroni 2026-04-28T06:27:17.821731+00:00 Effect of Topiramate on Mitochondrial Biogenesis and Neuroinflammation in Chronic Constriction Injury and Streptozotocin-induced Peripheral Neuropathy 2023-01-01 10.5530/ijper.57.3s.71 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-626.pdf Background: Because neuropathic pain is currently a poorly understood medical condition, there is a need to identify a more effective therapeutic drug with a low toxicity profile. Purpose: To address the behavioural, oxidative stress, and cytokine-mediated inflammatory pathways involved in sciatic nerve, the current study protocol used Chronic Constriction Injury (CCI) and Streptozotocin (STZ) induced neuropathic pain methods. Materials and Methods: Following CCI to the sciatic nerve and adminis Topiramate, CCI, STZ, Oxidative Stress, Cytokines https://www.ijper.org/lycorine-attenuates-airway-inflammation-in-an-ova-induced-allergic-asthma-model 2026-04-17T09:38:37.085535+00:00 Lycorine Attenuates Airway Inflammation in an OVA induced Allergic Asthma Model 2023-01-01 10.5530/ijper.57.3.92 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-756.pdf Background: Asthma is one of the most prevalent, complex, and severe respiratory disorders, with rising rates of occurrence and death in both children and adults. An alkaloid derived from plants, lycorine possesses several pharmacological effects, primarily anti-inflammatory and antioxidative properties. Materials and Methods: In the current study, the anti-asthmatic potential of lycorine against ovalbumin (OVA)-induced asthma mice model has been examined. The animals were categorized into five Asthma, Ovalbumin, Lycorine, Inflammatory cytokines, Oxidative stress https://www.ijper.org/article/57/3s/s742-s748 2026-04-28T06:32:48.410115+00:00 Multicomponent Synthesis, Characterization of Novel Pyrimidine Derivatives with Anti-cancer Potential 2023-01-01 10.5530/ijper.57.3s.84 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-742.pdf Background: Design and development of target specific anti-cancer agents is a central research goal. Materials and Methods: Substituted pyrimidines were synthesized from substituted enamine, triethoxy methane and ammonium acetate. Characterization was done using IR, 1H-NMR, and mass spectra. Cytotoxicity was tested using MTT Assay on A 549, B16F10, SiHA, and MCF-7 cells. Results: Synthesized derivatives displayed noticeable cytotoxicity against tested cancer cell lines. Conclusion: Evaluated cel Multicomponent synthesis, Pyrimidines, Anti-cancer https://www.ijper.org/effects-of-artemisinin-on-anti-epileptogenic-antioxidant-and-cholinesterase-enzy 2026-04-17T09:38:32.935325+00:00 Effects of Artemisinin on Anti-epileptogenic, Antioxidant and Cholinesterase Enzymes in Pentylenetetrazole-induced Kindling Model in Mice 2023-01-01 10.5530/ijper.57.3s.93 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-821.pdf Background: Artemisinin (ART) is a compound synthesized from the plant Artemisia annua. This compound has various therapeutic effects and is widely used against malaria. However, ART is known to have modulating effects on GABA (gamma-aminobutyric acid) receptors, which are thought to be responsible for epileptic seizures. This study aimed to evaluate the effects of ART on anti-convulsant, antioxidant, and cholinesterase enzyme activities in Pentylenetetrazole (PTZ)-induced kindling model in mice Anti-convulsant, Antioxidant, Cholinesterases, Pentylenetetrazole, Kindling model, Artemisinin https://www.ijper.org/article/57/3s/s718-s723 2026-04-28T06:31:06.456486+00:00 Evaluation of Anti-obesity Activity of n-hexane and Methanolic Extracts of Cajanus cajan Linn. Seeds Using Enzymatic Methods 2023-01-01 10.5530/ijper.57.3s.81 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-718.pdf Objectives: To evaluate the in vitro anti-obesity activity of Cajanus cajan Linn. seeds. Materials and Methods: Phytochemical screening and in vitro studies on pancreatic lipase and alpha-glucosidase activity were performed using methanolic and n-hexane extracts at doses of 100-500 mcg/mL. Results: Cajanus cajan Linn. seeds extracts possess dose-dependent inhibitory activities, showing good anti-obesity potential. Conclusion: Preliminary studies reveal significant potential for treating obesity Obesity, Cajanus cajan, Pancreatic lipase https://www.ijper.org/synthesis-of-cyclopyrrolidine-clubbed-with-oxadiazole-bases-and-evaluation-of-th 2026-04-28T06:33:14.366874+00:00 Synthesis of Cyclopyrrolidine Clubbed with Oxadiazole Bases and Evaluation of their Anti-Diabetic Activity through in vivo Model 2023-01-01 10.5530/ijper.57.3s.85 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-749.pdf Background and Aim: Based on inhibitors of DPP-IV, there is a fantastic method for creating anti-diabetic medications. These inhibitors regulate diabetic patients' blood sugar levels to prevent difficulties with their health. In the current work, we created a brand-new series of compounds Cyclopyrrolidine clubbed with oxadiazole bases. Materials and Methods: Cyclopyrrolidine clubbed with oxadiazole bases (B-1 to B-16) were synthesized and characterized through IR, NMR, mass spectrometry, and ele Furadiazole, Hyperglycaemic, HFD-STZ-Nicotinamide https://www.ijper.org/IndJPhaEdRes-57-2s-i 2026-04-28T05:33:37.365929+00:00 Editorial: Navigating the Frontiers in Pharmaceutical Sciences: A Digest of Review and Original Articles 2023-01-01 10.5530/ijper.57.2s.i https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-2s-i.pdf As an editor of this esteemed journal, it is my pleasure to introduce the brilliant research encapsulated in the new issue, featuring a compilation of intriguing review and original articles that cover a broad spectrum of pharmaceutical sciences. The review articles commence with an enlightening piece on the utilization of PLGA, an innovative biodegradable polymer, in drug delivery systems, authored by Sonawane, Pingale, and Amrutkar. They delve into the groundbreaking capabilities of this polym Editorial https://www.ijper.org/neuroprotective-effects-of-withaferin-a-nanoparticles-on-scopolamine-rat-model-o 2026-04-28T06:27:00.889599+00:00 Neuroprotective Effects of Withaferin-A Nanoparticles on Scopolamine Rat Model of Alzheimer’s Disease 2023-01-01 10.5530/ijper.57.3s.70 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-620.pdf Background: Alzheimer's Disease (AD) suffers from dementia more often in 65-year or older patients. Symptoms of AD's are linked to disease-causing neurons, and current pharmacological therapies inadequately regulate deadly outcomes. Withania somnifera (L), has been contributing as a traditional multifunctional herb with a wide variety of health benefits. Materials and Methods: This research examined the importance of Withaferin A nanoparticles against scopolamine induced neuron loss (Impair on m Withaferin-A, EPM, Brain enzymes, Inflexion ratio, Nano formulations https://www.ijper.org/article/57/3s/s758-s765 2026-04-28T06:33:39.942231+00:00 Understanding the Trending of Laboratory Investigations as Part of Quality Management Systems-A Quality Assurance Perspective 2023-01-01 10.5530/ijper.57.3s.86 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-758.pdf Background: In the pharmaceutical sector, the effectiveness of the laboratory and its compliance with regulatory standards is critical in establishing an effective Quality Management System (QMS). Objectives: The present study was undertaken to carry out the laboratory investigation which is an integral aspect of a QMS, and is often used to investigate non-conformity in results in order to determine the most possible root cause. Materials and Methods: Laboratory investigation data is retrieved f Laboratory investigations, Quality management system, CAPA, HPLC, GC https://www.ijper.org/formulation-characterization-and-cytotoxic-effect-of-pva-incorporated-iron-oxide 2026-04-28T06:42:46.699991+00:00 Formulation, Characterization, and Cytotoxic Effect of PVA Incorporated Iron Oxide Nanoparticles of Gramine Using HCT-116 Cell Line in vitro 2023-01-01 10.5530/ijper.57.4.123 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1021.pdf Background and Objectives: Globally, Colorectal cancer is the major cause of death. The current work emphasizes the synthesis of Gramine-loaded polyvinyl alcohol (PVA) coated Iron Oxide nanoparticles (NPs) and the evaluation of the antiproliferative and anticancerous activity in the HCT 116 cell line. Materials and Methods: The physiochemical, structural, and morphological characteristics of synthesized Gramine loaded PVA coated Iron Oxide NPs were assessed by UV-Visible spectrophotometer, Fouri Colorectal cancer cell line, Gramine, Polyvinyl alcohol, Iron oxide nanoparticles, Drug delivery https://www.ijper.org/implementation-of-analytical-quality-by-design-methodology-to-develop-a-uv-spect 2026-04-28T06:35:53.154714+00:00 Implementation of Analytical Quality by Design Methodology to Develop a UV-spectrometric Technique for Arteether Quantification 2023-01-01 10.5530/ijper.57.3s.91 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-805.pdf Aim/Background: Analytical Quality by Design refers to applying the Quality by Design idea to the development of analytical procedures. The present study emphasizes the AQbD concept of developing and validating a spectrophotometric technique for detecting α, β-arteether per the ICH Q8 (R2) requirements for the first time. Materials and Methods: Sample preparation, sample pH, and wavelength were all integrated into the Ishikawa diagram, and essential parameters were obtained. The ratio of ethanol α, β-arteether, Analytical method development, Accuracy, Acid degradation, ICH, Malaria, Quality by Design (QbD), UV-spectrometry https://www.ijper.org/formulation-and-evaluation-of-nano-co-crystal-based-oral-disintegrating-tablet-o 2026-04-28T06:25:58.219666+00:00 Formulation and Evaluation of Nano Co-Crystal Based Oral Disintegrating Tablet of Ezetimibe 2023-01-01 10.5530/ijper.57.3s.67 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-587.pdf Background: Low solubility, poor permeability, and hepatic drug degradation are the primary factors responsible for the poor bioavailability issues of orally administered drugs. Ezetimibe, a biopharmaceutics classification system (BCS) Class II anti-cholesteremic drug, has a bioavailability between 35% and 65% due to its substantial intestinal and first-pass metabolism. Objectives: An alternative method for drug administration is to be attempted on an orally disintegrating Ezetimibe tablet to av Ezetimibe, Micro crystalline cellulose, Oral Disintegrating Tablets, Nano co-crystals, Fast release, Dissolution https://www.ijper.org/impact-of-pistacia-lentiscus-plant-gum-on-particle-size-and-swelling-index-in-ce 2026-04-28T05:47:45.882485+00:00 Impact of Pistacia lentiscus Plant Gum on Particle Size and Swelling Index in Central Composite Designed Amoxycillin Trihydrate Mucoadhesive Microspheres 2023-01-01 10.5530/ijper.57.3.93 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-763.pdf Objectives: The ambition of this study is to find the mucoadhesive assets of Pistacia lentiscus plant gum (mastic gum) by combining it into mucoadhesive microspheres with Amoxicillin Trihydrate (ATH). Significance: Due to its short stomach residence duration, ATH is efficient against H. pylori but can be improved by creating Mucoadhesive Microspheres (MMS) that keep Amoxicillin trihydrate in the stomach. In this study, Pistacia lentiscus plant gum has been exposed to have gastroprotective and H. Mastic gum, Microspheres, Mucoadhesive, Particle size https://www.ijper.org/nanoemulgel-formulation-of-tetrahydrocurcumin-with-efficient-anti-inflammatory-e 2026-04-28T06:18:05.608166+00:00 Nanoemulgel Formulation of Tetrahydrocurcumin with Efficient Anti-inflammatory Effect for the Treatment of Skin Disorders 2023-01-01 10.5530/ijper.57.3s.61 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-528.pdf Introduction: Tetrahydrocurcumin (THC) is a partially reduced white metabolite of curcumin which does not impart yellowish colour on skin due to which it seemed to be a promising topical agent compared to curcumin which discoloured the skin with long lasting visible mark. Objectives: The research work was intended to formulate THC loaded Nano Lipid-based (TNL) Carbopol Gum Gel (TNLCG) also called tetrahydro curcumin nanoemulgel and to investigate its therapeutic efficacy against inflammation usi Tetrahydro-curcumin, Anti-inflammatory, Nanoemulgel, Permeation, Topical-delivery https://www.ijper.org/marker-based-standardization-of-quercetin-in-marketed-capsules-by-novel-zero-ord 2026-04-28T06:34:27.755334+00:00 Marker Based Standardization of Quercetin in Marketed Capsules by Novel Zero Order Spectroscopic and Area Under Curve Spectroscopic Methods 2023-01-01 10.5530/ijper.57.3s.88 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-772.pdf Background: Quality control and standardization of phytomedicines play a vital role in herbal drug industries. Marker based quantification and standardization is one of the essential approaches used in quality evaluation of herbal products. The Quercetin is an important flavonoid having variety of therapeutic activities and many formulations are available in the market. Capsule dosage form of Quercetin is largely marketed. The main objective for analytical development of proposed research is to Area Under Curve, Marker Based Quantification, Quality Control, Quercetin, Zero Order Spectroscopy https://www.ijper.org/citrollenol-abrogates-neuroinflammatory-pathway-regulated-via-induction-of-nf-kb 2026-04-17T09:38:28.281953+00:00 Citrollenol Abrogates Neuroinflammatory Pathway Regulated via Induction of NF-kB in AlCl3 Induced Alzheimer’s Disease – Molecular Approach 2023-01-01 10.5530/ijper.57.4.127 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1053.pdf Background: Alzheimer's Disease (AD), a neurodegenerative disorder characterized by dementia, is linked to ROS-induced stress, neuroinflammation, and gut microbiota imbalance. Objectives: The antioxidant and anti-inflammatory properties of citrollenol have already been reported. The current research was aimed at discovering the salutary properties of citrollenol against Aluminum Chloride (AlCl3)-induced AD in rats. Materials and Methods: The AlCl3 was used to induce the AD in rats and then treat Alzheimer’s, AlCl3, NF-kB, Malonaldehyde, Citrollenol, Neuroinflammation https://www.ijper.org/stability-indicating-reverse-phase-high-performance-liquid-chromatography-method 2026-04-28T06:33:59.431098+00:00 Stability Indicating Reverse Phase-High Performance Liquid Chromatography Method for Simultaneous Estimation of Cabotegravir and Rilpivirine 2023-01-01 10.5530/ijper.57.3s.87 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-766.pdf Background: For the estimation of cabotegravir and rilpivirine in the bulk and pharmaceutical dosage form, a stability-indicating reverse-phase high-performance liquid chromatography method was developed and validated using an inertsil C18 (150 x 4.6 mm, 5 µm) column. At a flow rate of 1.0 ml/min, a mobile phase containing a mixture of 0.01N ammonium acetate buffer (pH 3) and acetonitrile (65:35, v/v) was passed over the column. The column temperature was set at 30°C. A photodiode array detector Cabotegravir, Rilpivirine, RP-HPLC, Method Validation, Stability studies https://www.ijper.org/article/57/3/883-889 2026-04-13T07:01:23.744128+00:00 LC-MS/MS Analytical Method Development and Validation for Determining Vinamidinium HexafluoroPhosphate Impurity in Etoricoxib 2023-01-01 10.5530/ijper.57.3.106 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-883.pdf Background and Aim: Process impurities may adversely affect the efficacy, excellent quality, and safety of pharmaceutical drugs. Ultimately, the purpose of this research work was to develop and validate a LC-MS/MS-based method for determining the Vinamidinium hexafluorophosphate impurity (VHP) in Etoricoxib in a simple, specific, accurate, and precise manner. Materials and Methods: To elute the Vinamidinium hexafluorophosphate impurity in Etoricoxib at a flow rate of 0.5mL/min within 20.0 min of Vinamidinium Hexafluorophosphate (VHP), Etoricoxib (ETC), International Conference on Harmonization, LC-MS/MS https://www.ijper.org/article/57/3s/s499-s506 2026-04-28T06:15:43.156067+00:00 Analyzing Biosimilars in Brazil: Comprehensive Specifications of the Regulatory System 2023-01-01 10.5530/ijper.57.3s.57 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-499.pdf The largest nation in South America, Brazil, is now the world's second-largest market for pharmaceuticals thanks to the country's economic growth. The Brazilian Health Surveillance Agency, also known as the National Agency for Health Surveillance (Agencia Nacional de Vigilancia Sanitaria - ANVISA), was founded in 1999 with the primary objective of protecting and strengthening public health surveillance over Brazilian products and services. Biological products, also known as biopharmaceuticals, a ANVISA, Regulations, Guidelines, Biosimilars, Pathway https://www.ijper.org/identifying-potential-drug-candidates-against-plasmodium-falciparum-isolate-3d7 2026-04-17T09:38:34.540609+00:00 Identifying Potential Drug Candidates against Plasmodium falciparum (Isolate 3D7) through Targeting ADP-dependent DNA Helicase RecQ: An in silico Approach 2023-01-01 10.5530/ijper.57.4.124 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1029.pdf Background: The malarial scenario has significantly varied in the past few decades; whether it is funding or the range of sophisticated life-saving tools that have been improved, the disease burden has reduced, and even a few nations are on the verge of their elimination. Despite these, drug resistance is the major hurdle in the fight against malaria. Aim: Identifying new drug candidates with negligible toxicity are imperative to overcome the existing problem. The proposed study aims to identify Malaria, Plasmodium falciparum, DNA helicase, PfWrn, Docking, MD simulation https://www.ijper.org/lupeol-in-functional-gastrointestinal-disorders-an-evidence-based-preclinical-st 2026-04-28T05:49:06.02357+00:00 Lupeol in Functional Gastrointestinal Disorders: An Evidence-based Preclinical Study 2023-01-01 10.5530/ijper.57.3.94 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-773.pdf Objectives: The current study assessed the possible use of lupeol in the treatment of intestinal inflammation for the initial instance and for the anxiolytic activity for the management of Functional Gastrointestinal Disorder (FGID) by two different models of colitis (IBD) TNBS and DSS and by two anxiolytic models EPM and OFT. Materials and Methods: The intestinal anti-inflammatory models of colitis were performed by using TNBS and DSS to obtain the possible use of lupeol at a dose of 25μg/mL an Functional Gastrointestinal Disorder, Irritable Bowel Disease, Trinitrobenzene sulfonic acid, Dextran Sodium Sulfate, Lupeol https://www.ijper.org/article/57/3/919-929 2026-04-13T07:02:45.724345+00:00 Correlation Between Efficacy of Treatment with Anti-psychotics and Adherence in Schizophrenic Patients: A Cross-sectional Study in Saudi Arabia 2023-01-01 10.5530/ijper.57.3.111 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-919.pdf Background: Schizophrenic patients’ adherence to medication regimens can determine clinical outcome success. This study focuses on medication adherence and its correlation with the efficacy of anti-psychotics. The study's goal is to (1) assess the efficacy of anti-psychotics and adherence using the Self-evaluation of Negative Symptoms (SNS) tool and Medication Adherence Rating Scale (MARS), and (2) examine the demographic and clinical factors that could impact both outcomes (SNS and MARS). Mater Schizophrenic patients, Anti-psychotics, Saudi Arabia, Medication regimen, Medication Adherence Rating Scale https://www.ijper.org/article/57/3s/s511-s519 2026-04-28T06:16:26.05397+00:00 Enhancement of the Solubility of Lipophilic Drug by Self-Micro Emulsifying Drug Delivery System (SMEDDS) For Oral Administration 2023-01-01 10.5530/ijper.57.3s.59 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-511.pdf Aim: The aim of this research work is the formulation, development and evaluation of Self-Micro Emulsifying Drug Delivery System (SMEDDS). Background: Zileuton, a drug that is poorly soluble in water, was formulated with Tween 20 in a 1:1 ratio as a surfactant. F1 formulation of SMEDDS was selected from the optimum concentration of oils, surfactant, and co-surfactants from psuedoternary diagrams. Materials and Methods: Enaltec Lab in Mumbai, India, provided Zileuton as a gift sample. Raj Chemica SMEDDS, Zileuton, Zeta potential https://www.ijper.org/bioactivity-guided-isolation-of-phytoconstituents-from-saraca-asoca-seeds-for-an 2026-04-28T06:28:21.169827+00:00 Bioactivity-guided Isolation of Phytoconstituents from Saraca asoca Seeds for Anti-asthmatic Potential 2023-01-01 10.5530/ijper.57.3s.76 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-667.pdf Objectives: It is interesting to consider biologically active substances derived from natural sources as potential novel medications for infectious disorders. Saraca asoca is an indigenous medicinal plant with lots of traditional importance belonging to the family Caesalpinaceae. As these plants have been ethno-pharmacologically claimed for the treatment of respiratory system-related disorders such as asthma, and cough, in addition, to treating inflammatory conditions. The anti-asthmatic activit Anti-asthmatic, Quercetin, Milk-induced leukocytosis, Eosinophilia https://www.ijper.org/ethnobotanical-study-of-medicinal-plants-used-traditionally-for-managing-cuts-an 2026-04-28T06:28:50.138875+00:00 Ethnobotanical Study of Medicinal Plants Used Traditionally for Managing Cuts and Wounds by the Rural People of Kailashpur, Assam, India 2023-01-01 10.5530/ijper.57.3s.77 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-678.pdf Background: Folk medicinal knowledge of plants is vital in primary health care management system, predominantly in rural and remote areas. Managing cuts and wounds continues to be a significant healthcare issue. Materials and Methods: The information was collected through a semi-structured questionnaire from 30 informants in Kailashpur, Assam, India. Quantitative analysis of these data to find Use Value (UV), Frequency of Citation (FC), Family Use Value (FUV), Consensus Index (CI), Rehman's Simi Ethnobotanical survey, Kailashpur village, Medicinal plants, Cuts, Wounds https://www.ijper.org/preparation-and-optimization-of-microwave-assisted-ball-milled-olmesartan-medoxo 2026-04-28T06:20:17.759895+00:00 Preparation and Optimization of Microwave-Assisted Ball-Milled Olmesartan Medoxomil with Chitosan Using Full 3^2 Factorial Design 2023-01-01 10.5530/ijper.57.3s.64 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-555.pdf Introduction: The anti-hypertensive drug Olmesartan Medoxomil (OLM), a BCS II drug, works by inhibiting the action of angiotensin II on AT1 receptors. Objectives: The purpose of the study was to enhance solubility and stability by altering crystalline form, which reduces cost and dose burden of the pharmaceutical industry. In the current study, OLM formulation was prepared by using a full 3 level 2 factorial design with chitosan and neusiline as independent factors. Materials and Methods: Chitos Microwave-assisted milling technology, Chitosan, Olmesartan, Neusiline, Factorial Design https://www.ijper.org/chitosansesbania-gum-mediated-ph-responsive-polyelectrolyte-complexes-for-target 2026-04-28T06:22:41.514122+00:00 Chitosan–Sesbania Gum Mediated pH-Responsive Polyelectrolyte Complexes for Targeted Delivery of Diclofenac Sodium: Preparation and Spectroscopical Evaluation 2023-01-01 10.5530/ijper.57.3s.65 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-564.pdf Background: The implementation of chitosan as an enhanced vehicle for drug delivery is an interesting domain in the pharmaceutical dosage form. The combination of commonly accessible natural polysaccharides like gum may provide a new arrangement of dosage forms such as polyelectrolyte complex. Such modern improvements facilitate the modulated release of active, which can be beneficial in avoiding adverse consequences. There have been no reports on chitosan and sesbania gum-based polyelectrolyte Chitosan, Sesbania gum, Diclofenac sodium, Polyelectrolyte complex, Drug delivery https://www.ijper.org/punica-granatum-juice-as-an-oral-supplemental-therapeutic-effect-on-hemoglobin-a 2026-04-28T05:50:18.488661+00:00 Punica granatum Juice as an Oral Supplemental Therapeutic: Effect on Hemoglobin and Blood Glucose Levels among Diabetic Patients 2023-01-01 10.5530/ijper.57.3.95 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-782.pdf Background: Type II Diabetes Mellitus (T2DM) is one of the most common metabolic disorders and it is often associated with complications like hyper-lipidemia, anemia, cardiovascular and inflammatory disorders. The present study was conducted to evaluate the effect of consumption of Punica granatum (pomegranate) juice (PJ) on Fasting Blood Glucose (FBG) and haemoglobin concentration in patients with T2DM. Materials and Methods: The study was conducted for a period of 60 days. Twenty patients with Fasting blood glucose, Haemoglobin concentration, Metformin treatment, Pomegranate juice, Type II diabetes mellitus https://www.ijper.org/mucoadhesive-chitosan-coated-plga-nanoparticles-of-ashwagandha-extract-for-colon 2026-04-28T06:41:16.305059+00:00 Mucoadhesive Chitosan-Coated PLGA Nanoparticles of Ashwagandha Extract for Colon-Targeted Delivery 2023-01-01 10.5530/ijper.57.4.119 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-971.pdf Aim/Background: Withania somnifera (Ashwagandha) belongs to the Solanaceae family, well known for its phyto-pharmacological properties such as anti-inflammatory, antioxidant, anti-stress, immunomodulatory, and anticancer properties. The study aimed to formulate and evaluate chitosan-coated PLGA nanoparticles of ashwagandha extract. The nanoparticle formulation technique was considered in order to rectify the various constraints associated with ashwagandhas, such as intestinal absorption, burst r Ashwagandha, Nanoparticles, Chitosan, PLGA, Anti-cancer activity https://www.ijper.org/sustainable-antimicrobial-nanomaterials-a-promising-treatment-for-multiple-drug 2026-04-17T09:38:23.397724+00:00 Sustainable Antimicrobial Nanomaterials: A Promising Treatment for Multiple Drug Resistant Microorganisms 2023-01-01 10.5530/ijper.57.4.115 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-937.pdf ABSTRACT: Antibacterial drugs had an essential role in the treatment of various diseases from a long-time whereas excess use leads to resistance and toxicity which is a great challenge in the health sector. The most important factors responsible for the spread of antibiotic resistance includes globalization, self-medication, repetitive and excess use of antimicrobials, continuous intake of broad-spectrum agents, and less availability of an effective antimicrobial agents. The increased resistance Nanomaterial, Antibiotic resistant, Microorganism, Metal, Antibacterial, Chemotherapy https://www.ijper.org/ameliorating-the-poor-dissolution-rate-of-selexipag-in-aqueous-acidic-conditions 2026-04-17T09:38:22.100257+00:00 Ameliorating the Poor Dissolution Rate of Selexipag in Aqueous Acidic Conditions Following Confinement into Mesoporous Silica 2023-01-01 10.5530/ijper.57.4.122 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1002.pdf Background: Pulmonary Arterial Hypertension (PAH) is a serious condition with available treatment options, including Selexipag (SXP), a selective prostacyclin receptor agonist that has effectively reduced patient morbidity and mortality. SXP is limited by poor water solubility, especially in acidic solutions, which can affect its bioavailability and therapeutic efficacy. Therefore, strategies to tackle the solubility of SXP, such as nano-based Drug Delivery Systems (DDSs), should be explored. Ob Mesoporous silica, Drug dissolution, Selexipag, Solubility, Pulmonary arterial hypertension, Crystallinity https://www.ijper.org/article/57/3/787-796 2026-04-28T05:51:58.392476+00:00 Triptonide Protects against Doxorubicin-induced Cardiotoxicity in Rats by Regulating Oxidative Stress and Cardiac Biomarkers 2023-01-01 10.5530/ijper.57.3.96 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-787.pdf Background: Doxorubicin is an anthracycline anti-cancer drug and one of the most widely used chemotherapeutic medications to treat both solid and hematological tumors. However, due to the major adverse effect of cardiotoxicity, the clinical use of doxorubicin was highly restricted. Objectives: The current research was undertaken to explore the salutary properties of the triptonide on the doxorubicin-induced cardiotoxicity in rats. Materials and Methods: Rats were given 2.5 mg/kg of doxorubicin t Creatine kinase, Cardiac damage, Myoglobulin, Doxorubucin, Triptonide https://www.ijper.org/biotherapeutic-potential-of-lactobacillus-probiotic-strains-on-streptococcus-mut 2026-04-28T06:40:55.09871+00:00 Biotherapeutic Potential of Lactobacillus Probiotic Strains on Streptococcus mutans Biofilm in Dental Caries-Pathogenesis Revisited 2023-01-01 10.5530/ijper.57.4.117 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-956.pdf This review gives an insight on the anticariogenic role of each of the individual strains of Lactobacillus probiotics on Streptococcus mutans bacterium associated with dental caries and also attempts to emphasize the commercially approved oral probiotic products using Lactobacillus strains exclusively, against dental caries. Probiotics in bacteriotherapy have been an emerging strategy in the management of ‘Dental caries’. Probiotics, protect the tooth surfaces from the competing microbial pathog Biofilm, Dental caries, Lactobacillus, Probiotics, Streptococcus mutans https://www.ijper.org/an-analysis-of-the-extent-of-intra-and-inter-rater-variability-in-osce 2026-04-17T09:38:34.196498+00:00 An Analysis of the Extent of Intra and Inter-rater Variability in OSCE 2023-01-01 10.5530/ijper.57.3s.58 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-507.pdf Background: OSCE is an objective structured clinical examination, though the tool is designed to increase the objectivity in the examination of the clinical cases, the inter and intra rater variability of the tool needs to analysed. Aim: To determine the extent of intra and inter-rater variability in OSCE. Settings and Design: The study was conducted in a medical college and is a cross sectional study. Materials and Methods: 5 OSCE stations were designed and videos recorded of the candidates per OSCE, Variability, Inter rater, Intra rater https://www.ijper.org/knowledge-and-risk-factors-regarding-type-2-diabetes-among-saudi-population-in-j 2026-04-17T09:38:36.688849+00:00 Knowledge and Risk Factors Regarding Type 2 Diabetes among Saudi Population in Jeddah 2023-01-01 10.5530/ijper.57.3.112 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-930.pdf Aim: Public awareness of type 2 diabetes is a requirement for individuals and communities to help prevent the disease. Therefore, this study aimed to assess the level of knowledge and awareness of type 2 diabetes among diabetic and non–diabetic persons in Jeddah region, Kingdom of Saudi Arabia (KSA). Materials and Methods: A structured questionnaire was established and a total of 325 respondents (male = 180 and female = 145) have joined this study and descriptive analysis was used to evaluate th Type 2 diabetes, Saudi Arabia, Knowledge, Risk factors, Control, Awareness https://www.ijper.org/article/57/4/1112-1118 2026-04-13T07:23:14.627862+00:00 Evaluation of Antioxidant and Oxidative Stress Activity of Carthamus tinctorius L. Extract in Lung Cancer A549 Cells 2023-01-01 10.5530/ijper.57.4.134 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1112.pdf Background: C. tinctorius (safflower) natural food colorant and has been used to control high blood pressure, supress oxidation, cancer immunosuppressive drug, inhibits blood clots, dilate blood vessels, and as neuroprotective agents. Several investigations indicate the relationship between oxidative processes and emergence of cancer. The current investigation data confirms the antiproliferative activity of Safflower against A549 cancer cell line but little is known about their antioxidant mecha Safflower, Antioxidant, Anti-cancer, Lipid Peroxidase, Nitric Oxide, Polymerase Chain Reaction https://www.ijper.org/lyophilized-nlc-of-cinacalcet-hcl-physics-of-tablet-compression-and-biopharmaceu 2026-04-17T09:38:22.270483+00:00 Lyophilized NLC of Cinacalcet HCl: Physics of Tablet Compression and Biopharmaceutical Characterization 2023-01-01 10.5530/ijper.57.3.83 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-684.pdf Background: Cinacalcet Hydrochloride (CINH) is a BCS class IV drug. It is mainly used for the treatment of chronic renal disease and parathyroid cancer. It exhibits poor oral bioavailability less than 25%. The main objective is to improve the bioavailability and stability of CINH by formulating the lyophilized Nanostructure Lipid Carrier (NLC) into tablet dosage form. Materials and Methods: In this research, Glycerylmonostearate (GMS), labrasol, tween 20 were the main excipients selected for the Compactibility, Cryoprotectant, Crystalinity, Bioavailability and Cytotoxicity https://www.ijper.org/hazelnut-has-potency-on-wound-healing-associated-with-immunohistochemical-biomar 2026-04-17T09:38:22.447859+00:00 Hazelnut Has Potency on Wound Healing Associated with Immunohistochemical Biomarkers 2023-01-01 10.5530/ijper.57.3.91 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-748.pdf Background: In this study, it was aimed to evaluate the impact of hazelnut on wound healing by using its immunohistochemical impacts on Claudin-5, Tumor Necrosis Factor-alpha (TNF-a), tumor Protein-63 (p63), and Insulin-like Growth Factor-1 (IGF-1) expression. Materials and Methods: Seventy-two male Wistar-Albino rats were used. Nine groups with 8 rats each group, and 3, 7, and 14 days groups were formed as oral, local, and control groups. Samples obtained from rats were evaluated with these imm Wound, Healing, Hazelnut, Immunohistochemical, Biomarkers https://www.ijper.org/artemetin-a-dietary-flavonoid-inhibits-the-proliferation-and-induces-apoptosis-i 2026-04-17T09:38:28.130233+00:00 Artemetin, A Dietary Flavonoid Inhibits the Proliferation and Induces Apoptosis in Human Gastric Carcinoma (AGS) Cells 2023-01-01 10.5530/ijper.57.4.139 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1167.pdf Background: One of the most common types of recurrent carcinoma cases worldwide is gastric cancer. Even advances in treatment methods and early discoveries have not been able to significantly lower the death and morbidity rates associated with gastric cancer. On account of their multiple health benefits, apparent lack of toxicity and side effects, and the limitations of chemotherapeutic drugs, natural products have attracted a lot of interest in recent years with the aim of preventing cancer. Ai Gastric cancer, Artemetin, AGS cells, Reactive oxygen species, Apoptosis https://www.ijper.org/article/57/3s/s814-s820 2026-04-13T10:09:38.183311+00:00 Chemical Composition and Therapeutic Effects of Ammodicus leucotricus Essential Oils on Neurobehavioral Changes in Wistar Rats after Experimental Scorpion Envenomation 2023-01-01 10.5530/ijper.57.3s.92 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-814.pdf Background: Our study consists of a study of the chemical composition of the essential oil administered to a batch of rats undergoing a scorpion sting. Compared with control batches, the nervous state was evaluated by several neurobehavioral tests, namely open classified, dark and light and forced swimming. Materials and Methods: Determination of the composition of the essential oil the plant by GC/MS and its protective effect on the nervous system after exposure of rats to scorpions. Results: o Scorpion, Rat, Ammodicus leucotricus, Neurobehavioral test https://www.ijper.org/a-novel-bioanalytical-method-for-simultaneous-determination-of-olanzapine-and-sa 2026-04-28T05:59:00.200373+00:00 A Novel Bioanalytical Method for Simultaneous Determination of Olanzapine and Samidorphan in Human Plasma Using RP-HPLC 2023-01-01 10.5530/ijper.57.3.105 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-873.pdf Background: Schizophrenia patients are given with a combined medication of Olanzapine (OLA) and Samidorphan (SAM). A sensitive bioanalytical RP-HPLC technique has to be needed to analyse these drugs in biological samples, hence we have been developed a method for simultaneous determination of OLA and SAM in human plasma. Materials and Methods: The separation was conducted on a Zorbax SB-C18 column (250 mm x 4.6 mm, 5μ) and an isocratic mobile phase of 10 mM ammonium acetate and acetonitrile (60: Olanzapine, Samidorphan, Zorbax, Ammonium acetate, Acetonitrile https://www.ijper.org/in-vitro-and-in-silico-protective-effects-of-ascorbic-acid-on-nicotine-treated-h 2026-04-28T06:43:17.306732+00:00 In vitro and in silico Protective Effects of Ascorbic Acid on Nicotine-treated Human Erythrocytes (Preliminary Studies) 2023-01-01 10.5530/ijper.57.4.125 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1037.pdf Objectives: Nicotine is one of the most addictive naturally occurring drugs and is commonly found in tobacco products. Tobacco products are one of the most common causes of lung and oral cancer all over the world. As the main organ in contact with nicotine is the blood, our aim in the present study was to confirm its effect on the blood, We also studied the protective role of ascorbic acid on nicotine toxicity. Materials and Methods: Different blood toxicity study-related experiments such as Sup Nicotine, in silico, in vitro, Ascorbic acid, Erythrocytes, Antioxidant https://www.ijper.org/herbal-nanoparticles-a-commitment-towards-contemporary-approach 2026-04-17T09:38:24.093064+00:00 Herbal Nanoparticles: A Commitment towards Contemporary Approach 2023-01-01 10.5530/ijper.57.3s.55 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-465.pdf Herbal medicines have been used extensively since ancient times in almost every region of the world and are regarded by patients and doctors as having the best therapeutic value or effect because they have very few or lesser side effects than synthetic medications. In order to deliver the components over time, avoid the need for repeated dose administration, and improve patient compliance, phytotherapeutics requires some scientific approaches. The current article discusses the various kinds of n Herbal Nanoparticles, Herbal Drugs, Nano Formulations, Nanofertilizers https://www.ijper.org/article/57/4/1044-1052 2026-04-28T06:44:05.378424+00:00 In silico Discovery of STRA 6 Vitamin A Receptor, as a Novel Binding Receptor of COVID-19 2023-01-01 10.5530/ijper.57.4.126 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1044.pdf A global pandemic of pneumonia caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in Wuhan, China, at the end of 2019. Although, the ACE2 receptor has been demonstrated to be the main entry receptor of COVID-19, but our docking analysis, predicted and discovered a novel receptor termed STRA 6 that may play a critical role in the pathogenicity of COVID-19. STRA6 receptor expressed in many organs and immune cells, upregulated by retinoic acid jm6 (STRA 6) was the firs COVID-19, STRA6, ACE2, Molecular docking https://www.ijper.org/commercially-available-vitamin-a-palmitate-is-toxic-and-teratogenic-to-the-tadpo 2026-04-28T05:54:39.976738+00:00 Commercially Available Vitamin A Palmitate is Toxic and Teratogenic to the Tadpoles of Microhyla nilphamariensis (Anura: Microhylidae) 2023-01-01 10.5530/ijper.57.3.99 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-813.pdf Aim/Background: The present study, examined the impact of excess Vitamin A on feeding and pre-metamorphic tadpoles of Microhyla nilphamariensis to analyse its dose-dependent and stage-specific lethal and teratogenic effects. Materials and Methods: Feeding and pre-metamorphic stage tadpoles were subjected to varying concentrations of commercially available Vitamin A palmitate for different time intervals. The control and treated tadpoles were fixed 5, 10- and 15-Days Post Treatment (dpt) in neutr Tadpoles, Feeding stage, Pre-metamorphic stage, Histology, Morphometry https://www.ijper.org/article/57/4/993-1001 2026-04-13T10:04:52.447952+00:00 Design, Development and Optimization of Buccal Tablet Containing Extract of Terminalia chebula Retz. for the Treatment of Asthma 2023-01-01 10.5530/ijper.57.4.121 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-993.pdf Objectives: The aim of the study was to design, develop, and optimize the buccal tablets containing extract of Terminalia chebula Retz. for the treatment of asthma. Materials and Methods: Buccal tablets were made using the direct compression method, and screening tests with various polymers were run to see how they affected the properties of the tablets. The utilisation of response surface methods, two polymer types, carbopol® and HPMC, were chosen for additional optimization research. Strength Terminalia chebula Retz., Buccal tablet, HPMC K15, Optimization, Carbopol, DoE https://www.ijper.org/assessment-of-the-suitability-of-the-delphi-method-for-assessing-the-needs-of-ph 2026-04-17T09:38:24.263394+00:00 Assessment of the Suitability of the Delphi Method for Assessing the Needs of Pharmacoeconomic Studies in the Decision-Making Process 2023-01-01 10.5530/ijper.57.4.147 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1232.pdf Background: Increasing need for control in healthcare spendings and for publicly available services, opens new areas and topics that needs to be discussed. The aim of this paper is assessment of the technic adequacy for evaluation of knowledge level in the subject territory. Materials and Methods: Systematic review has been performed with electronic database PubMed and MEDLINE. The SPIDER model (Sample, Phenomenon of Interest, Design, Evaluation, Research Type) was used to create the search stra Delphi method, Qualitative methods, Pharmacoeconomic, Decision-making https://www.ijper.org/article/57/4/1140-1149 2026-04-13T07:24:11.412638+00:00 Evaluation of Anti-inflammatory Effects of Polysaccharide Derived from Plantago ovata Husk on Trinitro Benzenesulfonic Acid-induced Ulcerative Colitis in Mice 2023-01-01 10.5530/ijper.57.4.137 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1140.pdf Background: Ulcerative colitis, an idiopathic, chronic inflammatory illness of the intestinal mucosa is primarily fuelled by inflammation and oxidative stress. Aim: The present study aimed to investigate the anti-inflammatory and antioxidant effects of Plantago ovata husk in mice with Trinitro Benzenesulfonic Acid (TNBS)-induced Ulcerative Colitis (UC). Materials and Methods: BALB/c mice were exposed to TNBS intrarectally, causing ulcerative colitis. All mice received diet supplemented with Plan Plantago ovata, Polysaccharide, Ulcerative colitis, TNBS, Inflammation https://www.ijper.org/article/57/4/1061-1070 2026-04-28T06:44:45.070477+00:00 Neuroprotective Effect of Ruscogenin against Cognitive Impairment on Pentylenetetrazole-induced Epileptic Seizures in Rats 2023-01-01 10.5530/ijper.57.4.128 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1061.pdf Background: Epilepsy, which affects about 1% of the world's population, is the third most common neurological disease after stroke and Alzheimer's disease. It is characterized by recurrent spontaneous seizures due to abnormal neuronal excitability and hypersynchrony. Objectives: The current work was aimed at discovering the neuroprotective properties of ruscogenin against Pentylenetetrazole (PTZ)-induced epilepsy in rats. Materials and Methods: The epileptic episode was induced in the rats by in Seizure, Gammaaminobutyric acid, Nitric oxide synthase, Ruscogenin, SHSY-5Y cells https://www.ijper.org/role-of-stem-cells-in-the-management-of-type-i-diabetes-mellitus 2026-04-28T06:40:14.499839+00:00 Role of Stem Cells in the Management of Type-I Diabetes Mellitus 2023-01-01 10.5530/ijper.57.4.116 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-951.pdf The paper aims to accent Type-1 DM along with its etiology, pathophysiology, and treatment in this review. Diabetes is considered the chronic ailment of hypoglycemia ensuing from the duo of the dearth of insulin action and secretion of insulin considered as both. Moreover, Type-1 is a result of autoimmune of the cells of islets of the pancreas. The confrontation to the insulin or secretion of insulin lacking due to changes in living standards, habit change, dearth of exercise along with aging al Diabetes Mellitus, Stem cells, Hyperglycemia https://www.ijper.org/formulation-and-evaluation-of-antifungal-drug-containing-mucoadhesive-tablet-for 2026-04-28T06:24:59.701063+00:00 Formulation and Evaluation of Antifungal Drug Containing Mucoadhesive Tablet for Vaginal Candidiasis 2023-01-01 10.5530/ijper.57.3s.66 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-573.pdf Objectives: Female population frequently seeks medical consultation for the vaginal candidiasis. Voriconazole (VOR) is a BCS class II antifungal drug with low aqueous solubility and hence inclusion complex was formulated using Hydroxypropyl--cyclodextrin (HPCD). The complex was incorporated into mucoadhesive vaginal tablet using Chitosan and Hydroxypropyl Methyl Cellulose (HPMC K100). Materials and Methods: A 3^2 full factorial design was employed for sustained release tablet using Design expert Voriconazole, Factorial design, Inclusion complex, Vaginal Candidiasis, Sustained release, In vitro antifungal activity, In vitro release https://www.ijper.org/knowledge-attitude-and-acceptance-towards-coronavirus-disease-2019-covid-19-vacc 2026-04-28T06:02:22.649859+00:00 Knowledge, Attitude and Acceptance towards Coronavirus Disease 2019 (COVID-19) Vaccines among Healthcare Students of a Tertiary Care Teaching Hospital in South India: A Cross-sectional Study 2023-01-01 10.5530/ijper.57.3.110 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-911.pdf Background: Coronavirus disease 2019 (COVID-19) has imposed a serious health impact afflicting millions of people and halting global progress significantly. Albeit vaccines for COVID-19 emerged as a potent approach to overcome the morbidity, its suspicion had been persisting across diverse categories of people, including healthcare students. Since studies exploring the acceptance of vaccines among healthcare students from India were limited, this study has been formulated to evaluate the knowled COVID-19, Vaccines, Knowledge, Attitude, Healthcare students https://www.ijper.org/palliative-action-of-woodfordia-fruticosa-leaves-containing-woodfruticosin-on-bi 2026-04-28T06:45:16.840739+00:00 Palliative Action of Woodfordia fruticosa Leaves Containing Woodfruticosin on Biological Redox Imbalance and Anemia in CFA-Induced Arthritic Rats 2023-01-01 10.5530/ijper.57.4.131 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1087.pdf Background: Rheumatoid Arthritis (RA) is a chronic disorder affecting musculoskeletal and autoimmune system with inflammatory characteristics. Anemia is most prevailing, among other extra-articular complications in RA. These complications are analogous to exorbitant inflammation and biological redox imbalance which ultimately affects the quality life and life expectancy of RA patients. Objectives: The study was planned to investigate the palliative action of Woodfordia fruticosa (WF) leaf extrac Rheumatoid arthritis, Chromatography, Isolation, Spectroscopy, Woodfruticosin https://www.ijper.org/hydrogel-films-of-citric-acid-cross-linked-hydroxypropyl-methylcellulosemethylce 2026-04-17T09:38:24.757208+00:00 Hydrogel Films of Citric Acid Cross-linked Hydroxypropyl Methylcellulose/Methylcellulose for Hydrophilic Drug Delivery 2023-01-01 10.5530/ijper.57.3.87 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-718.pdf Aim: To develop hydrogel films for hydrophilic drug delivery with citric acid-cross-linked Hydroxypropyl Methylcellulose (HPMC) and Methylcellulose (MC). Materials and Methods: The existing study is concerned with the development of HPMC/MC hydrogel films employing citric acid as a cross-linking agent in order to accomplish drug loading while simultaneously releasing hydrophilic drugs (ciprofloxacin hydrochloride). Thermal analysis and ATR-FTIR spectroscopy were used to explore the hydrogel film Hydroxypropyl methylcellulose, Methylcellulose, Citric acid, Hydrophilic drug, Cross-linked hydrogel films, Ciprofloxacin hydrochloride, Drug delivery https://www.ijper.org/design-and-application-of-the-blended-teaching-mode-in-the-curriculum-of-pharmac 2026-04-17T09:38:26.491807+00:00 Design and Application of the Blended Teaching Mode in the Curriculum of Pharmacokinetics 2023-01-01 10.5530/ijper.57.4.141 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1183.pdf Introduction: Pharmacokinetics is one of the main courses of pharmacy majors in medical colleges and universities. The course is highly practical involving multidisciplinary collaboration, with strong logical reasoning and complex calculations. But the widespread traditional teaching methods resulted in poor practical application ability, self-learning ability, and problem-solving ability of students. Objectives: To enhance the students' knowledge and problem-solving ability, we focused on the c Curriculum, Blended teaching mode, Pharmacokinetics, Pharmaceutical students https://www.ijper.org/an-overview-on-development-approval-and-post-registration-activities-for-pharmac 2026-04-28T06:48:53.650997+00:00 An Overview on Development, Approval and Post Registration Activities for Pharmaceuticals in European Union 2023-01-01 10.5530/ijper.57.4.144 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1208.pdf Background: Bringing a new medicine from concept to market is costly and complex. Years of study and development go into it. Product development operations should be carried out in line with applicable regulatory standards to save time and money when bringing innovations to the marketplace. While the information on regulatory requirements is readily accessible, navigating the regulatory system is complex and becomes considerably more difficult when working with many countries. The primary goal i Product Lifecycle Management, Navigation Pathway, New Product Development, Post Approval Changes, Regulatory Review, European Union https://www.ijper.org/article/57/4/983-992 2026-04-28T06:41:47.529575+00:00 Central Composite Design Assisted Formulation Development and Optimization of Gastroretentive Floating Tablets of Dextromethorphan Hydrobromide 2023-01-01 10.5530/ijper.57.4.120 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-983.pdf Objectives: The existing study is concerned with the formulation and optimization of dextromethorphan hydrobromide floating tablets via central composite design. Materials and Methods: Direct compression method was employed to prepare the tablets. Drug -excipient studies were executed through FT-IR and DSC analysis. The independent variables selected were the concentrations of Carbopol 934 (X1) and HPMC K15M (X2). The dependent variables designated were Floating Lag Time (FLT) and Drug Release ( Dextromethorphan Hydrobromide, Carbopol, HPMC, Central Composite design, Floating lag time https://www.ijper.org/evaluation-of-sinapic-acid-on-stz-induced-depression-in-diabetic-wistar-rats 2026-04-17T09:38:29.579378+00:00 Evaluation of Sinapic Acid on STZ-induced Depression in Diabetic Wistar Rats 2023-01-01 10.5530/ijper.57.4.133 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1104.pdf Objectives: Presently, diabetes is a major chronic metabolic abnormality characterized by sustained hyperglycemia. Diabetic neuropathy, encephalopathy, diabetes induced anxiety, depression is common life-threatening complications in which hyperglycemia mediated oxidative stress plays major role in pathogenesis. Sinapic acid is a phenolic acid, reported with anti-inflammatory, antioxidant, anti-bacterial, anti-tumor, anxiolytic activity and also it is proven to be neuroprotective in diabetic neur Sinapicacid, STZ, Diabetes, Depression https://www.ijper.org/synergistic-and-toxicity-reducing-effects-of-periplaneta-americana-extract-c-3-c 2026-04-28T06:46:44.03991+00:00 Synergistic and Toxicity-reducing Effects of Periplaneta americana Extract CⅡ-3 Combined with CTX on H22 Tumor Bearing Mice 2023-01-01 10.5530/ijper.57.4.135 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1119.pdf Background: Cyclophosphamide (CTX) is widely used in tumor treatment, but its clinical therapeutic effect is not ideal due to many side effects. Materials and Methods: In the present study, we researched the synergistic and attenuating effects of CⅡ-3 combined with CTX and their underlying mechanism in H22 tumor-bearing mice. Firstly, we established an H22 tumor-bearing mice model, and the body weight, tumor weight, and survival time were recorded. Secondly, HE staining of tumor tissue was perfo Anti-tumor, Cyclophosphamide, Immune depression, Periplaneta americana, Synergism and attenuation https://www.ijper.org/article/57/3s/s734-s741 2026-04-28T06:31:59.559513+00:00 The Formation Analysis of Ca (II), Mg (II), Zn (II) and 5-Hydroxysalicylic Acid Binary Complexes in Cetyltrimethylammonium Bromide Cationic Micelles 2023-01-01 10.5530/ijper.57.3s.83 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-734.pdf Aim: The aim of the study is to confirm the species formed and validate models by statistical treatment. Materials and Methods: Alkali metric titrations were carried out in CTAB-water mixtures using sodium hydroxide. Results: Formed metal-ligand complexes are ML2H3, ML2H4, and ML3H4. Conclusion: Speciation of complexes reveals compartmentalization of metabolic reactions and gives insight into metal transport in bio fluids. Binary complexes, Stability constants, Cationic micelles https://www.ijper.org/article/57/4/1219-1225 2026-04-28T06:51:05.310882+00:00 Analysis of ICH-Q3D Endorsed Elemental Impurities in Macrolide Antibiotics by ICP-MS 2023-01-01 10.5530/ijper.57.4.145 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1219.pdf Aim: The objective of this study was to determine the amount of twenty-three elemental impurities in Azithromycin API. A rapid, selective, precise, accurate and sensitive approach for detecting elemental impurities in Azithromycin API was developed and validated using Inductively Coupled Plasma-Mass Spectrometry (ICP-MS). Background: Conventional analytical methods used in pharmacopoeia’s are less sensitive and accurate to detect heavy metal impurities. Concerning this issue, a new inductively c Azithromycin API, Elemental Impurities, Inductively coupled plasma mass spectrometry, Method Development, ICH Guidelines https://www.ijper.org/interaction-studies-of-moxifloxacin-with-anti-diabetic-drugs-and-application-of 2026-04-28T06:51:25.903018+00:00 Interaction Studies of Moxifloxacin with Anti-diabetic Drugs and Application of RP-HPLC in Analysis 2023-01-01 10.5530/ijper.57.4.146 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1226.pdf Aim: Simple RP-HPLC method was developed and validated for the simultaneous estimation of Glimepiride, Glibenclamide and Moxifloxacin in pharmaceutical preparation. Materials and Methods: Mediterranean C18 column with dimensions of 150mm×4.6mm was used with HPLC Shimadzu LC-20 AT model, Version 1:62 is used for processing of chromatograms at room temperature (25± 2°C). 1 mL per minute was the flow rate and detector were set at 254nm with mobile Phase consisting of 85:10:5 v/v methanol: water: ac Moxifloxacin, Glimepiride, Glibenclamide, in vitro interaction studies https://www.ijper.org/the-attitude-knowledge-and-evaluation-of-herbal-medicinal-products-for-respirato 2026-04-17T09:38:24.427733+00:00 The Attitude, Knowledge, and Evaluation of Herbal Medicinal Products for Respiratory Diseases in Northern Cyprus among Pharmacists, Patients, and Pulmonologists 2023-01-01 10.5530/ijper.57.4.148 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1242.pdf Background: The utilization of Complementary and Alternative Medicine (CAM) has grown remarkably over the years as people seek alternative treatment methods to conventional medicine to manage various health conditions. Aim: The study aimed to assess the utilization of herbal remedies in treating respiratory disorders, enhance the safe and efficient use of herbal medicinal products, and raise awareness of the effectiveness of CAM in respiratory tract diseases in Northern Cyprus. Materials and Met Complementary and Alternative Medicine, Pharmacists, Herbal Medicinal Products, Respiratory Diseases https://www.ijper.org/development-evaluation-and-in-vitro-anti-acne-activity-of-tretinoin-nanocrystals 2026-04-17T09:38:36.85829+00:00 Development, Evaluation, and in vitro Anti-Acne Activity of Tretinoin Nanocrystals Gel 2023-01-01 10.5530/ijper.57.4.114 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1012.pdf Background: Tretinoin is generally used to treat acne vulgaris and photoaging. The study aimed to develop a gel composition containing tretinoin nanocrystals and characterize and compare in vitro anti-acne activity. Materials and Methods: The anti-solvent precipitation approach was used to prepare tretinoin nanocrystals. The drug nanocrystals were optimized for parameters such as particle size, drug content, and drug release. The optimized nanocrystals (TN9) were incorporated into the gel system Tretinoin, Nanocrystals, Gel, Drug release, Anti-acne activity, Propionibacterium acnes, Staphylococcus epidermidis https://www.ijper.org/binding-study-of-monohydroxy-cucurbit7uril-with-rhodamine-b 2026-04-28T05:56:08.003578+00:00 Binding Study of Monohydroxy Cucurbit[7]uril with Rhodamine B 2023-01-01 10.5530/ijper.57.3.100 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-822.pdf Background: Cucurbit[7]uril (CB[7]) is the most important host among the reported cucurbit[n]urils family members, because it exhibited unique molecular recognition with exceptional applications. The binding affinity of functionalized CBs, especially mono hydroxylated CB[7] is important, because it will help to understand the difference in binding profile of functionalized CB[7] in comparison to that of the parent CB[7]. Materials and Methods: We have utilized Rhodamine B (RhB) to get encapsulat Cucurbit[7]uril, Encapsulation, Host-guest chemistry, Rhodamine B, Binding constant, Monohydroxy-Cucurbit[7]uril https://www.ijper.org/article/57/3/728-735 2026-04-28T05:43:36.013308+00:00 Formulation of Candesartan Cilexetil Nanoparticles by Ionotropic Gelation Method Using Ultrasonication 2023-01-01 10.5530/ijper.57.3.88 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-728.pdf Aim: Candesartan Cilexetil (CC) is a common drug used by patients suffering from hypertension and heart diseases. However, CC has poor oral bioavailability as it belongs to Biopharmaceutical Classification System (BCS) class II and has low aqueous solubility. This research work is focused to enhance the Bioavailability of CC using nanotechnology. Therefore, CC nanoparticles were developed using the ionic gelation procedure and ultrasonication. Materials and Methods: This work is aimed to formula Candesartan cilexetil, Ionic gelation, Ultrasonication, Sodium alginate, Pluronic F-68 https://www.ijper.org/solid-state-characterization-and-miscibility-of-raltegravir-in-soluplus-using-so 2026-04-28T06:19:47.449469+00:00 Solid State Characterization and Miscibility of Raltegravir in Soluplus Using Solid Dispersion Technology 2023-01-01 10.5530/ijper.57.3s.63 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-548.pdf Background: Raltegravir Potassium (RTGP), a BCS class II drug used in the treatment of HIV, has minimal solubility in the aqueous medium, resulting in poor bioavailability; Further, RTGP poor dissolution and limited solubility are also major factors responsible for the significant inter- and intra-patient variability in absorption following oral administration. Objectives: To enhance the solubility of Raltegravir potassium and its free acid using Soluplus® by solid dispersion technology. Materia Raltegravir, Amorphous salt solid dispersion, Amorphous solid dispersion, Quench cooling, Solubility https://www.ijper.org/effect-of-a-herbal-formulation-on-infection-prevention-and-immune-regulation-in 2026-04-28T06:52:34.431843+00:00 Effect of a Herbal Formulation on Infection Prevention and Immune Regulation in Children with Frequent Relapse Nephrotic Syndrome 2023-01-01 10.5530/ijper.57.4.149 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1251.pdf Objectives: This study aims to investigate the effect of a herbal formulation "Guyuan Tang" on preventing the recurrence of children with frequent relapse nephrotic syndrome and its influence on immune function. Materials and Methods: In all, 30 children with frequent relapse nephrotic syndrome were randomly divided into the Traditional Chinese Medicine (TCM) group and the control group. The control group was treated with conventional western medicine, while the TCM group was treated with Guyuan Frequent relapse nephrotic syndrome, Infection, Traditional Chinese Medicine, Immune, Children https://www.ijper.org/applying-hands-on-inquiry-learning-in-physical-chemistry-teaching-practice-to-im 2026-04-28T06:48:02.60932+00:00 Applying Hands-on Inquiry Learning in Physical Chemistry Teaching Practice to Improve Teaching Quality 2023-01-01 10.5530/ijper.57.4.140 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1175.pdf Background: Physical chemistry is an important theoretical basic course that supports the development of medicine and pharmacies. Physical chemistry teaching is usually a process of traditional teaching and passive acceptance. The teaching method is singular, and students lack an interest and the ability of autonomous learning. Objectives: The purpose of the study is to explore the application of a hands-on inquiry learning strategy blending independent learning based on information resources fl Hands-on inquiry learning, Higher pharmacy education, Active learning, Teaching strategy, Problem-based learning https://www.ijper.org/multiparticulate-floating-beads-an-aid-to-enhance-therapeutic-efficacy-of-rabepr 2026-04-28T06:19:27.538449+00:00 Multiparticulate Floating Beads an Aid to Enhance Therapeutic Efficacy of Rabeprazole 2023-01-01 10.5530/ijper.57.3s.62 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-540.pdf Background: Rabeprazole sodium is a newer generation anti-ulcer drug with short half-life and low bioavailability. Present research work is an attempt to design novel floating beads of Rabeprazole sodium in multiparticulate dosage form to increase residence time and modulate its release behavior for stomach-specific delivery. Materials and Methods: In this present study, Rabeprazole sodium beads were formulated by ionotropic gelation method and effect of variation in sodium alginate and gellan g Floating beads, Rabeprazole, Buoyancy, In vivo Radiography, Mucoadhesion https://www.ijper.org/designing-of-trifluoromethyl-substituted-pyrimidine-pharmacophore-for-antiprosta 2026-04-28T05:56:50.205412+00:00 Designing of Trifluoromethyl Substituted Pyrimidine Pharmacophore for Antiprostate Activity through a Collective Computational Approach 2023-01-01 10.5530/ijper.57.3.101 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-827.pdf Background: Prostate cancer is one of the leading causes of death. Though many drugs are being used as effective anticancer agents resistance and side effects necessitates development of target selective and safe anticancer agents. Objectives: The objectives of our work were to identify the important pharmacophoric features and correlate structure of Trifluoro substituted pyrimidine and predict their anticancer activity using QSAR, pharmacophore modelling, and docking studies. Materials and Meth Prostate cancer, QSAR, Combilib, ADME, PASS, OSIRIS, Docking https://www.ijper.org/combination-of-n-acetyl-cysteine-and-thymoquinone-alleviates-hepatocellular-toxi 2026-04-17T09:38:26.656062+00:00 Combination of N-acetyl Cysteine and Thymoquinone Alleviates Hepatocellular Toxicities by Radiation and CCl4 Intoxication in SD Rats 2023-01-01 10.5530/ijper.57.3.98 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-802.pdf Radiation and chemicals were the major clinical toxicants known to cause cellular damage during prognostic interventions in vivo. Cellular and molecular damages in the liver were the major causes for the hepatocellular injury due to various toxicities. Though many antioxidants alleviate various types of hepatotoxicities, protection exerted by the combination of N-acetyl cysteine (NA) and Thymoquinone (TQ) in the combined toxicities of radiation and carbon tetrachloride (CCLR) in Sprague-Dawley ( N-acetyl cysteine, Thymoquinone, Carbon tetrachloride, Radiation toxicity, NfkB, MMP https://www.ijper.org/mentorship-in-pharmacy-schools-students-perspective 2026-04-17T09:38:26.829945+00:00 Mentorship in Pharmacy Schools: Students’ Perspective 2023-01-01 10.5530/ijper.57.3.81 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-669.pdf Introduction: Mentorship is seen as key to enhanced self-efficacy, and overall improvement in students' academic performance. However, information on how this affects academic performance in pharmacy schools in Nigeria is scarce. The study identified existing forms of mentorship, appraised the perceived contributions of mentorship to pharmacy students' academic performance, and assessed the benefits obtained by pharmacy students from student-mentor interactions in pharmacy schools in Southwest N Mentorship, Learning, Academic performance, Education, Study habits, Mentees https://www.ijper.org/article/57/3/864-872 2026-04-28T05:58:11.239225+00:00 LC-MS/MS and NMR Studies for Identification and Characterization of Forced Degradation Products of Acalabrutinib 2023-01-01 10.5530/ijper.57.3.104 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-864.pdf A new method named "Stability Indicating LC-MS/MS" was developed to make analysis on acalabrutinib and this method was stable for this anticancer drug. In acid, basic and oxidation the drug was shown instability on these stress conditions. Acalabrutinib was used to form four degradation products and the developed method was used to separate based on “Zorbax C18 column (150 mm x 4.6 mm, 5 µm)" and for this separation the technique isocratic elution was used with the flow rate of 1.0 mL/min. It wa Acalabrutinib, Isolation, Characterization, Forced Degradation Studies, LC-MS/MS, NMR https://www.ijper.org/luliconazole-loaded-niosomal-topical-gel-factorial-design-in-vitro-characterizat 2026-04-28T06:17:20.991973+00:00 Luliconazole Loaded Niosomal Topical Gel: Factorial Design, in vitro Characterization and Antifungal Study 2023-01-01 10.5530/ijper.57.3s.60 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-520.pdf Aim/Background: This research work intended to make use of prospective advantages of niosomes for the improvement in topical delivery of poorly soluble luliconazole. Materials and Methods: Luliconazole, an anti-fungal agent used in the treatment of fungal infection, was successfully formulated as niosomal topical gel by using a polymer carbopol 934. The 32 full factorial statistical design was employed as a means for the optimization of niosomal formulation to check the impact of two formulation Poorly soluble drug, Nanocarrier, Topical application, Antifungal study https://www.ijper.org/stability-indicating-reversed-phase-hplc-method-development-and-validation-for-e 2026-04-17T09:38:26.992288+00:00 Stability-Indicating Reversed Phase-HPLC Method Development and Validation for Estimation of Phenylephrine in Bulk and Tablet 2023-01-01 10.5530/ijper.57.3s.90 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-798.pdf Background: This study is aimed to develop a validated stability-indicating method of a nasal decongestant phenylephrine hydrochloride in bulk and tablet. Materials and Methods: A sensitive, accurate, and specific reversed-phase stability indicating HPLC method was developed and validated by following ICH guidelines, for the estimation of Phenylephrine Hydrochloride (PHE) in bulk and tablet. On Luna® 5µm C18 column (250 × 4.6mm), the isocratic separation was achieved using mobile phase of 5mM am Chromatogram, High performance liquid chromatography, Decongestant, Degradation, ICH guidelines https://www.ijper.org/brassinin-exhibits-anti-diabetic-activity-against-streptozotocin-induced-diabete 2026-04-28T06:30:19.456047+00:00 Brassinin Exhibits Anti-Diabetic Activity against Streptozotocin-induced Diabetes Mellitus in Experimental Rats 2023-01-01 10.5530/ijper.57.3s.79 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-701.pdf Background: Diabetes mellitus is among the most serious public health problems worldwide. Materials and Methods: 35mg/kg STZ was injected to rats for stimulating diabetes. Then rats were treated with 25mg/kg of brassinin. Results: Brassinin and Glibenclamide remarkably decreased glucose and HbA1c levels in diabetic rats, while insulin levels were elevated. They also increased antioxidant enzymes and decreased inflammatory markers. Conclusion: Brassinin is an antihyperglycemic, antioxidant, and a Brassinin, Glycosylated haemoglobin, Oxidative stress, Inflammation https://www.ijper.org/evaluation-of-the-aqueous-extract-of-musa-acuminata-corm-rhizome-for-its-anti-di 2026-04-17T09:38:27.154944+00:00 Evaluation of the Aqueous Extract of Musa acuminata Corm (Rhizome) for its Anti-diabetic Potential in Streptozotocin (STZ) Induced Diabetic Zebrafish (Danio rerio) Model 2023-01-01 10.5530/ijper.57.4.129 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1071.pdf Background Information: Diabetes Mellitus (DM) is spiking substantially in both emerging and developed countries and the use of a nutritional approach to diabetes control has recently attracted a lot of attention. The banana (Musa spp.) is ubiquitously favourite in the tropical areas of the world. The wild plant species Musa acuminata, also referred to as the Cavendish banana, is found in tropical and subtropical climates. The health advantages of M. acuminata have drawn a lot of attention in re Diabetes mellitus, Musa acuminata Corm Extract (MACE), Anti-diabetic, Zebra fish https://www.ijper.org/32-factorial-design-of-ow-nanoemulsions-of-cholecalciferol-using-boxbehnken-mode 2026-04-17T09:38:26.319538+00:00 32 Factorial Design of O/W Nanoemulsions of Cholecalciferol Using Box–Behnken Model for Plaque Psoriasis 2023-01-01 10.5530/ijper.57.3.82 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-678.pdf Aim: The aim of the study was to design O/W Nanoemulsion using Cholecalciferol in different ratios of surfactants with Box-Behnken design model using Design Expert version 12. Response surface methodology, Box-Behnken was most suited followed by 3 independent variables (A, B, C) and 9 different responses with 17 different batches. Various responses like pH, % drug content drug entrapment and % in vitro drug release at different time intervals comparable with independent variables with % predicte Optimization, Nanoemulsion, Box-Behnken design, Psoriasis, 32 factorial designs https://www.ijper.org/in-vitro-and-in-vivo-antidiabetic-activity-of-ag-nanoparticles-mediated-from-gym 2026-04-28T06:30:31.88054+00:00 In vitro and in vivo Antidiabetic Activity of Ag Nanoparticles Mediated from Gymnemic Acid I and II 2023-01-01 10.5530/ijper.57.3s.80 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-710.pdf Background: Gymnema sylvestre is traditionally used to treat diabetes in Asia. Materials and methods: GA-I and GA-II were docked to PTP 1B. Nanoparticles were produced using centrifugation green synthesis. Results: Blood glucose levels significantly decreased (p less than 0.001) at a dose of 200 mg/kg of GA-I mediated AgNPs. Conclusion: GA-I mediated AgNPs can be exploited as prospective nanomedicine for type-2 diabetes. Gymnemic Acid-I, Molecular docking, PTP 1B https://www.ijper.org/evaluation-of-cytotoxic-potential-of-classical-siddha-medicine-padikara-parpam-i 2026-04-17T09:38:21.934845+00:00 Evaluation of Cytotoxic Potential of Classical Siddha Medicine Padikara Parpam in Human Monocytic Leukemic Cell Lines (THP-1) 2023-01-01 10.5530/ijper.57.3s.72 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-639.pdf Introduction: Padikara Parpam (PP), is one among the highly regarded Siddha medicine that is been traditionally claimed for its anti-proliferating and anti-carcinogenic properties. Objectives: In the present work, we investigated the cytotoxic effects of PP in a cellular model of Human leukemia (Human monocytic cell lines (THP-1). Materials and Methods: Determination of cell viability was assessed by the 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyl-tetrazolium bromide (MTT) assay and by using Con Siddha medicine, Padikara Parpam, Human Monocytic cell lines, Cytotoxic effects, Confocal Laser Scanning Microscope, MTT assay, Intracellular ROS assay https://www.ijper.org/nanosizing-approaches-current-trends-in-the-solubility-enhancement-of-poorly-wat 2026-04-17T09:38:27.471318+00:00 Nanosizing Approaches: Current Trends in the Solubility Enhancement of Poorly Water-soluble Drugs 2023-01-01 10.5530/ijper.57.3.77 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-625.pdf Nanosuspension formulation and production techniques are currently undergoing remarkable growth in pharmaceutical industries to address poor aqueous solubility and low bioavailability of active pharmaceutical ingredients. It has some distinct character and benefits over other methodologies used to enhance aqueous solubility. The controlled process including formulation and processing variables provide the requisite shape and size of the drug particles in the form of nanosuspension. Generally, dr Nanoparticles, Nanosuspension, Nanosizing approaches, Saturation solubility, Pharmacokinetics https://www.ijper.org/formulation-and-evaluation-of-nanoemulsion-of-the-phenolic-content-of-foeniculum 2026-04-28T06:28:05.383837+00:00 Formulation and Evaluation of Nanoemulsion of the Phenolic Content of Foeniculum vulgare for Antidepressant and Antihypertensive Potentiality 2023-01-01 10.5530/ijper.57.3s.75 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-660.pdf Objectives: Foeniculum vulgare (common name: fennel; family: Umbelifereae) is a well-documented plant with various medicinal properties to manage different types of disease. Depression and hypertension are associated with each other. The study focuses mainly on the evaluation of the antidepressant and antihypertensive effect of the nanoemulsion formulations of the phenolic content of the arial part of Foeniculum vulgare. Materials and Methods: The nanoemulsion formulation (1% and 2% W/V) formula Nanoemulsion, Essential oil, Foeniculum vulgare, Monoamine, Dopamine, Serotonin https://www.ijper.org/research-on-the-problem-centred-theory-pedagogy-to-improve-the-clinical-thinking 2026-04-28T06:01:54.045877+00:00 Research on the "Problem-Centred Theory" Pedagogy to Improve the Clinical Thinking Ability of Medical Students 2023-01-01 10.5530/ijper.57.3.109 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-905.pdf With the advent of the era of a knowledge economy, the teaching model of the problem-centred theory is widely concerned. This paper applies this teaching mode, takes the typical "abdominal pain" case as the problem centre, carries out the scenario design and teaching analysis, and explores the mode and way to improve the clinical thinking ability of medical students. Based on discussing the principles of problem situation design (including inspiration, vitality, conflict and interest), five modu Problem-centred theory, Diagnosis, Clinical thinking, Medical education https://www.ijper.org/advances-in-in-vivo-non-invasive-delivery-of-gentamicin 2026-04-17T09:38:27.309302+00:00 Advances in in vivo Non-invasive Delivery of Gentamicin 2023-01-01 10.5530/ijper.57.3.79 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-648.pdf Introduction: Parenteral administration of gentamicin is a globally known therapeutic strategy for severe infections, including severe community acquired pneumonia, complex severe acute malnourishment, neonatal and pediatric sepsis. The drug is also prescribed as an ophthalmologic anti-infective. In most cases, the therapeutic course necessitates frequent bolus medication doses, lengthy hospitalization, and ongoing therapeutic monitoring; hence a qualified healthcare provider is required. Object Gentamicin, Non-invasive, Aminoglycoside, Bioavailability, Permeability https://www.ijper.org/fluorescence-detection-of-etoposide-encapsulated-mesoporous-silica-nanoparticles 2026-04-17T09:38:21.600925+00:00 Fluorescence Detection of Etoposide Encapsulated Mesoporous Silica Nanoparticles by Environmentally Benign Bioanalytical HPLC Method and its Application to Pharmacokinetic Study 2023-01-01 10.5530/ijper.57.3.103 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-854.pdf Introduction: Etoposide belongs to BCS Class IV suffering from solubility and permeability limitations. Thereby, hindering its bioavailability. Thereby, it is imperative to enhance its bioavailability by suitable formulation to achieve a desired therapeutic effect. Objectives: In present work, ETD was encapsulated into mesoporous silica nanoparticles (MSNs) with the aim of achieving bioavailability enhancement. Further, A simple, efficient, and environmentally benign HPLC method with highly sens Etoposide, Mesoporous silica nanoparticles, Green metrics assessment, Pharmacokinetic study, Bioavailability enhancement https://www.ijper.org/2d-qsar-molecular-docking-and-in-silico-pharmacokinetics-analysis-on-n-substitut 2026-04-17T09:38:27.785965+00:00 2D-QSAR, Molecular Docking, and in silico Pharmacokinetics Analysis on N-substituted Urea and Thiourea Derivatives as Tankyrase Inhibitors for Implication in Cancer 2023-01-01 10.5530/ijper.57.3.102 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-838.pdf Objectives: Cancer is among four major Non-Communicable Diseases (NCD). Based on the World Health Organization (WHO), it is the biggest cause of mortality globally, claiming about 10 million lives in recent years. Tankyrases is a poly polymerase (ADP-ribose) family enzyme, inhibiting its enzymatic processes plays a crucial part in cancer etiology. Materials and Methods: The Algorithm of Kennard-Stone was utilized to develop QSAR models of thirty-four cytotoxic compounds of N-naphthoyl thioureas Cancer, QSAR, Docking, Tankyrase inhibitors https://www.ijper.org/inhibition-of-phenylhydrazine-induced-hematotoxicity-by-bioconverted-ginsenoside 2026-04-17T09:38:28.768951+00:00 Inhibition of Phenylhydrazine-induced Hematotoxicity by Bioconverted Ginsenosides 2023-01-01 10.5530/ijper.57.4.136 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1132.pdf Aim: To identify the inhibition of Phenylhydrazine (PHZ)-induced hepatotoxicity and anemia by bioconverted ginsenosides. Materials and Methods: We examined the potential benefits of bioconverted ginsenosides on anemia in a phenylhydrazine-induced rat model and described the prolonging effect of erythrocyte life span by focusing on compound K that was confirmed through ex vivo experiments. Results: Hematological analysis demonstrated that all groups treated with bioconverted ginsenosides showed s Anemia, Erythrocyte, Ginsenosides, Hemolysis, Phenylhydrazine https://www.ijper.org/investigation-of-in-vitro-and-in-vivo-pursuits-of-laurus-nobilis-extract-on-acet 2026-04-17T09:38:32.449485+00:00 Investigation of in vitro and in vivo Pursuits of Laurus nobilis Extract on Acetic Acid-induced Ulcerative Colitis in Wistar Rats 2023-01-01 10.5530/ijper.57.3s.73 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-644.pdf Background: The ethanolic extract of Laurus nobilis possesses an anti-inflammatory effect, which will protect against acetic acid-induced Ulcerative colitis by inhibiting endogenous free radicals. Objectives: The work has been undertaken to explore the efficacy and safety of ethanolic leaf extract of Laurus nobilis in treating acetic acid-induced Ulcerative colitis by estimating the biochemical, physical parameters, and histopathological studies. Materials and Methods: The plant powder of L. nob Laurus nobilis, Ulcerative Colitis, Anti-oxidant, Histological Studies, Ethanolic Extract https://www.ijper.org/evaluation-of-cognition-enhancing-activities-of-telmisartan-nimodipine-and-their 2026-04-28T06:26:36.716691+00:00 Evaluation of Cognition Enhancing Activities of Telmisartan, Nimodipine and their Combination in REM Sleep Deprived Wistar Rats 2023-01-01 10.5530/ijper.57.3s.69 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-610.pdf Background: Sleep Deprivation (SD) may lead to the failure of advanced neural functions, including decision-making, learning and memory. Studies show that nimodipine plays a role in intracellular Ca^2+ to reduced influx of Ca^2+ into mitochondria. Thereby, nimodipine improves the spatial cognition and elevates hippocampal acetylcholine. Telmisartan, has been proven to improve cognitive function in scopolamine induced amnesic rats. Aims: To evaluate the cognition enhancing activities of telmisart Cognition, Nimodipine, Telmisartan, Sleep deprivation, BDNF https://www.ijper.org/study-on-the-synthesis-and-hypolipidemic-activities-of-coumarin-oxime-esters-der 2026-04-17T09:38:27.95096+00:00 Study on the Synthesis and Hypolipidemic Activities of Coumarin Oxime Esters Derivatives 2023-01-01 10.5530/ijper.57.4.138 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1159.pdf Aim: The major objective of this research was to synthesize and evaluate the hypolipidemic Activities of Coumarin Oxime esters and develop the possible target. Materials and Methods: Using salicylaldehyde and ethyl acetoacetate as raw materials, coumarin-3-carboxylic acid was synthesized by Knoevenagel reaction, and then reacted with hydroxylamine hydrochloride to form oxime, which was then dehydrated and condensed with niacin and acetylsalicylic acid respectively to obtain six coumarin oxime es Coumarin, Oxime esters, Synthesis, Hypolipidemic, Targets https://www.ijper.org/formulation-and-evaluation-of-pluronic-f-127-assisted-carboplatin-cubosomes 2026-04-17T09:38:25.099987+00:00 Formulation and Evaluation of Pluronic F-127 Assisted Carboplatin Cubosomes 2023-01-01 10.5530/ijper.57.4.150 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1258.pdf Objectives: The objective of this study was to prepare carboplatin loaded cubosomes using high sheer homogenization technique. Materials and Methods: The cubosomes were prepared using Glyceryl Monooleate (GMO) as a lipophilic carrier along with pluronic F-127 (PF-127) and tween 80 as additive of the formulation. All the ingredients were subjected to chemical compatibility studies by Fourier Transform Infra-Red (FTIR) spectroscopy, thermal analysis using Differential Scanning Calorimetry (DSC), w Anticancer, Cubosomes, in vitro drug release, in vitro permeation studies https://www.ijper.org/influence-of-extraction-techniques-on-betalain-yield-and-bioactive-phytochemical 2026-04-17T09:38:29.254654+00:00 Influence of Extraction Techniques on Betalain Yield and Bioactive Phytochemical Analysis of Nopal Fruit Peels 2023-01-01 10.5530/ijper.57.4.130 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1078.pdf Background: Nopal fruits (Opuntia ficus-indica) and their peels contain significant amount of natural colorants which can be used in food and pharmaceutical applications instead of using synthetic dyes. Materials and Methods: The present study focuses on the extraction of betalain from nopal fruit peel by conventional and Ultrasound-Assisted Extraction (UAE) and optimizing the UAE process variables using Box Box-Behnken surface design, as well as a preliminary screening of valuable phytochemical Natural colorant, Ultrasound-assisted extraction, Response surface methodology, Anti-inflammatory, Anti-bacterial https://www.ijper.org/article/57/3s/s652-s659 2026-04-13T07:19:23.867128+00:00 Haematinic Activity of Nagaphani (Opuntia elatior Mill.) Swarasa through its Betalain Content on Phenylhydrazine-induced Haemolytic Anaemia in Rats 2023-01-01 10.5530/ijper.57.3s.74 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-652.pdf Aim: Woody shrubs of Nagaphani (Opuntia elatior Mill.) (Family: Cactaceae), bearing a pear shaped fleshy fruits rich in betalain content, vitamins and has antioxidant activities. Its fruits showed a great demand for its daily consumption in anaemic condition and also for its health benefits in general debilities. The present study aimed to rationalise folklore claim on Nagaphani at classical dose of original dosage i.e. swarasa (fresh expressed juice) in albino rats. Materials and Methods: Nagap Betalain, Haemolytic anaemia, Haematinic, Nagaphani, Phenylhydrazine, Opuntia elatior https://www.ijper.org/quality-by-design-based-quercetin-hydrate-nanoemulsions-for-enhanced-solubility 2026-04-17T09:38:31.934074+00:00 Quality by Design based Quercetin Hydrate Nanoemulsions for Enhanced Solubility by Reducing Particle Size 2023-01-01 10.5530/ijper.57.4.118 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-965.pdf Aim/Background: The oral-based drug delivery system has a great pace in this era of novel discoveries. The globe is running toward new medical dosage forms, but from the primer days of drug discovery to now, a major issue faced by pharmaceutical scientists is solubility and bioavailability issues. The nanoemulsions are the best suitable formulations which can upsurge the bioavailability of the insoluble drugs. In the past three years, many research activities have been conducted due to the pande Quercetin hydrate, Bioavailability, Design expert, Globule size, Nanoemulsion https://www.ijper.org/anti-aging-effect-of-panax-notoginseng-saponins-via-protecting-endogenous-antiox 2026-04-28T05:53:07.780532+00:00 Anti-aging Effect of Panax notoginseng Saponins via Protecting Endogenous Antioxidant in Fruit Flies 2023-01-01 10.5530/ijper.57.3.97 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-797.pdf Introduction: Panax notoginseng saponins (PNS), the main active ingredients extracted from Panax notoginseng, are chemical mixtures, with the five main active components of ginsenosides Rg1, Rb1, Re, Rd and notoginsenoside R1. Objectives: The present study investigated the effect of PNS on anti-aging in fruit flies, which represented as a natural physical organism aging model. Materials and Methods: After lifelong supplement of PNS in the culture medium at the concentration of 50, 100 and 200 mg Panax notoginseng saponins, Aging, Lifespan, Reproduction, Antioxidant enzyme https://www.ijper.org/application-of-multi-element-integrated-teaching-in-the-human-anatomy-and-physio 2026-04-17T09:38:29.910368+00:00 Application of Multi-element Integrated Teaching in the Human Anatomy and Physiology Course in Pharmacy Majors 2023-01-01 10.5530/ijper.57.4.142 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1192.pdf Background: A professional foundational course in human anatomy and physiology is required of pharmacy students to establish their understanding of the field. Since it includes human anatomy and human physiology, two crucial theoretical courses for medical students, the teaching material for these subjects was employed to adhere to the standards of medical disciplines rather than those of pharmacy. Objectives: This study aimed to establish a multi-element integrated teaching method for human ana Human anatomy and physiology, Pharmacy characteristics, Integrated teaching, Pharmaceutical students growing https://www.ijper.org/enhancement-of-avermectin-water-solubility-by-addition-of-poloxamer-188-and-deep 2026-04-17T09:38:30.234741+00:00 Enhancement of Avermectin Water-solubility by Addition of Poloxamer 188 and Deep Eutectic Solvent into PEG 6000 Solid Dispersion System 2023-01-01 10.5530/ijper.57.3.89 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-736.pdf Background: It has been reported previously that AV water-solubility was enhanced great by solid dispersion in PEG6k carrier. Materials and Methods: In this study, AV water-solubility was improved primarily by addition of PLX188 into PEG6k carrier, and further by addition of a deep eutectic solvent of CBU (choline chloride, betaine and urea) in the combinatory carrier of PEG6k and PLX188. Results: The result showed that the water-solubility of AV-PEG6k-PLX188 solid dispersion was 10.8 times of A Solid dispersion, Avermectin, Water-solubility, Stability, Bioavailability https://www.ijper.org/phytochemical-screening-acute-toxicity-study-and-pharmacological-evaluation-of-n 2026-04-28T06:45:31.481617+00:00 Phytochemical Screening, Acute Toxicity Study, and Pharmacological Evaluation of Natsiatum herpeticum Buch.Ham. ex Arn. 2023-01-01 10.5530/ijper.57.4.132 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1098.pdf Background: Plants are an open treasure of diverse pharmacologically active scaffolds. Natsiatum herpeticum, a least exploited plant, is known to be consumed by various ethnic groups of Asian origin as edible or as part of traditional remedy. Materials and Methods: The Ethanolic Extract of N. herpeticum (EENH) was evaluated for acute oral toxicity using acute toxic class method (OECD 423). Here, we aimed to investigate the free radical scavenging (antioxidant) and in vitro anti-inflammatory prop Acute toxicity, Antioxidant, Anti-inflammatory, Natsiatum herpeticum https://www.ijper.org/evaluation-of-anti-depressant-activity-of-spirulina-a-blue-green-algae-on-chroni 2026-04-17T09:38:25.45164+00:00 Evaluation of Anti-Depressant Activity of spirulina, a blue-green algae on Chronic Unpredictable Stress Induced Depression in Rats 2023-01-01 10.5530/ijper.57.4.113 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-4-1150.pdf Background: Depression is a crippling and pervasive illness that can affect a person in many different ways. It can be identified by certain symptoms, such as modifications in behaviour, psychological functioning, and brain physiology. Materials and Methods: One of the animal models for depression has been the Chronic Unpredictable Mild Stress (CUMS) paradigm. In this study, spirulina algae, which contains tryptophan, was chosen and tested for its anti-depressant effectiveness in the CUS model u Antidepressant, Spirulina algae, Force swim test, Tail suspensstion test, Sucrose preference test, Chronic Unpredictable Stress https://www.ijper.org/preparation-and-evaluation-of-polymer-fused-metformin-hydrochloride-sustained-re 2026-04-28T05:42:29.536533+00:00 Preparation and Evaluation of Polymer Fused Metformin Hydrochloride Sustained Release Tablet 2023-01-01 10.5530/ijper.57.3.86 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-711.pdf Introduction: Diabetes Mellitus (DM) is one of the most prevalent and chronic illnesses associated with an abnormally high level of glucose in the body which is hazardous to the body organs. Metformin Hydrochloride (HCl), a biguanide derivative is used for Type 2 DM. It has a relatively short plasma half-life and its regular administration is required to maintain a normal blood glucose level in diabetic patients. Therefore, sustained-release medications are a suitable approach to increase patien Metformin HCl, Pectin, Sodium Alginate, Diabetes Mellitus https://www.ijper.org/nanoemulgel-a-smarter-topical-lipidic-emulsion-based-nanocarrier 2026-04-28T06:14:59.368222+00:00 Nanoemulgel: A Smarter Topical Lipidic Emulsion-based Nanocarrier 2023-01-01 10.5530/ijper.57.3s.56 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3s-481.pdf In the last few decades, researchers have put a lot of time and effort into making new pharmaceuticals. As a result, there are now a huge number of pharmacological chemicals that can be used to treat a wide range of diseases that are a problem for the healthcare system. More than 50% of these medications are classed as BCS (Biopharmaceutical Classification System) class II/IV, indicating that they have limited therapeutic value and are not further studied. In this way, it has been shown that lip Nanoemulgel, Bioavailability, BCS class II and IV, Nanotechnology https://www.ijper.org/development-characterization-and-evaluation-of-cubosomes-loaded-smart-gel-for-th 2026-04-28T05:39:54.328137+00:00 Development, Characterization and Evaluation of Cubosomes Loaded Smart Gel for the Treatment of Osteomyelitis using 32 Factorial Design 2023-01-01 10.5530/ijper.57.3.84 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-57-3-695.pdf Aim: The main aim of present study is to formulate cubosomes containing curcumin. Curcumin is a BCS class IV drug which has clinically proven good anti-bacterial property. Materials and Methods: Cubic nanoparticles were prepared by hydrotrope dilution method. Cubosomes were formulated with the glyceryl monooleate and pluronic F-127 as a lipid and surfactant respectively, the obtained formulations were characterized for particle size, entrapment efficiency and zeta potential. Design of Experiment Osteomyelitis, Cubosomes, Smart gels, Curcumin, Design of Experiment https://www.ijper.org/phyto-therapeutic-potential-of-aconitum-ferox-roots-in-cfa-induced-arthritis-in 2026-04-13T05:54:23.472381+00:00 Phyto-therapeutic Potential of Aconitum ferox Roots in CFA-induced Arthritis in Rat Model 2022-10-25 10.5530/ijper.56.4s.218 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4s-725.pdf Background: To investigate the anti-arthritic potential of ethanolic extract of Aconitum ferox root (EAF) and isolation of a compound from the active fraction. Materials and Methods: The EAF obtained from successive solvent extraction was evaluated for antirheumatic action by complete Freund’s adjuvant (CFA) induced arthritis in adult Lewis rats (150-200gm) at 10mg/kg dose for prophylactic and therapeutic effect after acute toxicity study. Paw volume, body weight changes, locomotor activity, hem Aconite, Anti-arthritic, Delphinine, Alkaloid, Vatsanabh, CFA https://www.ijper.org/article/56/4s/S713-S723 2026-04-13T05:54:23.472381+00:00 In vivo and in vitro Hyperglycaemic Screening of Adenocalymma alliaceum Miers, A Promising Herb 2022-10-25 10.5530/ijper.56.4s.217 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4s-713.pdf Background: Ajos sacha is a shrubby herb and has attracted scientists’ attention due to its antioxidative, antineoplastic, larvicidal, and antibacterial properties. Hence, Ajos sacha assessed in vitro and in vivo diabetes protective properties. Materials and Methods: The methodology started with the quantitative phytochemical estimation of ethanolic extract of Adenocalymma alliaceum (EEAA). Then, the extract was studied for cytotoxicity, glucose utilization, and GLUT-4 redistribution. In vivo st β-cell, Alloxan monohydrate, Adenocalymma alliaceum, Glucose utilization, GLUT-4 redistribution, Diabetes Mellitus https://www.ijper.org/saccharomyces-cerevisiae-catalyzed-synthesis-and-evaluation-of-pyrazoles 2026-04-13T05:54:23.472381+00:00 Saccharomyces cerevisiae Catalyzed Synthesis and Evaluation of Pyrazoles 2022-10-25 10.5530/ijper.56.4s.215 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4s-695.pdf Background: Biocatalysis in organic solvents has several benefits over aqueous solvents, including solubility of organic substrates, ease of workup, separation of the product, and, in certain cases, reusability of biocatalysts. Materials and Methods: A simple, effective, and environmentally friendly technique for synthesizing pyrazoles has been established, which involves the cyclo condensation of chalcones and isonicotinic acid hydrazide in organic solvents using a relatively inexpensive cataly Pyrazoles, Chalcones, Saccharomyces cerevisiae, In vitro Anti-inflammatory, Antioxidant, Anti-tubercular https://www.ijper.org/carbon-nanotubes-an-optimistic-nanomaterial-with-superfluity-characteristics-in 2026-04-13T05:54:23.472381+00:00 Carbon Nanotubes: An Optimistic Nanomaterial with Superfluity Characteristics in Drug Delivery for the Treatment of Arthritis 2022-10-25 10.5530/ijper.56.4s.210 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4s-627.pdf Arthritis is chronic disease that affects the joint system and induces pain and inflammation in human body. Nanotechnology based drug delivery has progressed to be viable and more attractive for the treatment of arthritis. A carbon nanotube is one of the foremost prominent nanomaterials with high surface area utilized to exhibit stable release of drugs. Nonetheless, researchers have done investigations using either single-walled carbon nanotubes (SWCNT) or multi-walled carbon nanotubes (MWCNT) t Arthritis, Drug delivery system, Single-walled carbon nanotube, Toxicity, Multi- walled carbon nanotube, Nanoparticles https://www.ijper.org/design-development-and-characterization-of-film-forming-spray-as-novel-antifunga 2026-04-13T05:54:23.472381+00:00 Design, Development, and Characterization of Film Forming Spray as Novel Antifungal Topical Formulation for Superficial Fungal Infections 2022-10-25 10.5530/ijper.56.4s.211 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4s-651.pdf Introduction: Miconazole Nitrate is prescribed as an antifungal agent in conventional dosage forms. To mask the disadvantages of sticky creams and their tendency to rub off, an intelligent dosage regimen needs to be designed. Objectives: The present study aimed to design, develop, and characterize Miconazole Nitrate (0.5% w/v) film-forming spray for the treatment of superficial fungal infections in nails, such as Tenia and Onychomycosis. Materials and Methods: Eutectic mixture of Menthol and Cam Fungal Infections, Film-forming Spray, Miconazole Nitrate, Antifungal, Eutectic Mixture https://www.ijper.org/students-as-partners-how-the-student-centred-active-learning-concept-may-help-in 2026-04-13T05:54:23.472381+00:00 Students as Partners: How the Student-centred Active Learning Concept May Help Indian Pharmacy Education 2022-10-25 10.5530/ijper.56.4s.209 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4s-620.pdf The growing healthcare industry and the demand for a skilled workforce in India lead many students to enroll in medical and healthcare professional programmes. Pharmacy programmes in India prepare the students to deal with emerging opportunities in healthcare. Being a country with a great diversity of approaches, and the expectations of students from Generation Z, pharmacy education in India has an opportunity for rejuvenation to engage students in active learning. Educationalists and policymake Student engagement, Partnership, Pharmacy education, Active learning, Adult learning, Teaching and learning https://www.ijper.org/prediabetes-education-the-underutilized-tool-of-diabetes-prevention-among-indian 2026-04-13T05:54:23.472381+00:00 Prediabetes Education: the Underutilized Tool of Diabetes Prevention among Indian Population 2022-10-25 10.5530/ijper.56.4s.208 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4s-613.pdf Aim: This review aims to discuss the major effective educational interventions carried out among prediabetes population in different countries during the year 2001 to 2020. Materials and Methods: A PubMed, Science direct and Google Scholar detailed search was done on prediabetes education interventions and the search was limited to full text English articles with exclusions on articles with insufficient details. Youth diabetes prevention clinic for prediabetes, prediabetes booklet, web based mem Educational Intervention, India, Lifestyle modification, Prediabetes, Empowerment, Prediabetes Counseling, Health promotion https://www.ijper.org/neuroprotective-efficacy-of-quercetin-with-lamotrigine-and-gabapentin-against-pe 2026-04-13T05:54:23.472381+00:00 Neuroprotective Efficacy of Quercetin with Lamotrigine and Gabapentin Against Pentylenetetrazole-induced Kindling and Associated Behavioral Comorbidities in Mice 2022-10-25 10.5530/ijper.56.4s.212 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4s-659.pdf Aim: Epileptic seizure is a widespread neurological condition with multifaceted physiology. Numerous scientific data advise a therapeutic efficacy of bioflavonoids or bioactive compounds in epilepsy against oxidative stress pathway. Thus, the main objective of this investigation has been undertaken to explore the potential neuroprotective efficacy of Quercetin (Que) bioflavonoid with selected anti-epileptic drugs (AEDs) against pentylenetetrazole (PTZ) induced kindled model of convulsions in mic Lamotrigine, Neuroprotective effect, Anticonvulsant activity, Kindling model, Quercetin, Histopathological study https://www.ijper.org/design-synthesis-and-antibacterial-activity-of-certain-novel-indole-glyoxylamide 2026-04-13T05:54:23.472381+00:00 Design, Synthesis and Antibacterial Activity of Certain Novel Indole-glyoxylamide Conjugates 2022-10-25 10.5530/ijper.56.4s.214 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4s-682.pdf Objectives: To synthesize 2-Aryl 3-substituted indole-glyoxylamides to evaluate their antibacterial activity on target protein (4DH6). Materials and Methods: Computational techniques: The fused heterocyclic compound indole linked with glyoxylamide was designed by using computational techniques and also energy minimized. The molecular property and biological activities is determined by mol inspiration tool. The antibacterial target receptor/protein (PDB ID: 4DH6) have been selected for the dockin Auto dock, Molinspiration FTIR, ESI-MASS, Antimicrobial activity https://www.ijper.org/article/56/4s/S703-S712 2026-04-13T05:54:23.472381+00:00 Chromatographic Characterization for Quantitative Measurement of Phytoconstituents in Polyherbal Suspension and Evaluation of its Nutritional Efficacy on Malnourished Rats 2022-10-25 10.5530/ijper.56.4s.216 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4s-703.pdf Background: The present study demonstrated HPLC method development for quantitative measurement of phytoconstituents present in food-grade polyherbal suspension (PHS) and evaluated its nutritional efficacy in the rat. Procedure: The PHS was prepared by mixing the dried extracts of Nelumbo nucifera (NN) seeds, seeds of Euryale ferox (EF) and fruits of Trapa natans (TN) with other excipients. The PHS was analyzed using the HPLC method for the development and validation of the phytoconstituents pre Malnutrition, Polyherbal, HPLC, Validation, Biomarkers https://www.ijper.org/novel-uv-spectroscopic-methods-for-simultaneous-assessment-of-empagliflozin-lina 2026-04-13T05:54:23.472381+00:00 Novel UV Spectroscopic Methods for Simultaneous Assessment of Empagliflozin, Linagliptin and Metformin in Ternary Mixture 2022-10-25 10.5530/ijper.56.4s.213 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4s-669.pdf Background and Aim: Trijardy XR® consisting of empagliflozin, linagliptin, and metformin hydrochloride, a fixed-dose combination (tablets) that improves glycemic control in individuals with diabetes mellitus (type 2). The present work presents four spectrophotometric methods that are quick, effortless, accurate and reproducible for the concurrent assessment of the ternary mixture. Materials and Methods: The 1st approach works on the principle of solving established equations (simultaneous) by me Empagliflozin, Linagliptin, Metformin, Simultaneous Equation Method, Ratio, Difference Spectroscopic method, Derivative Ratio Spectrum-Zero crossing approach, Double Divisor Ratio Spectra Derivative approach, Ternary mixture https://www.ijper.org/article/56/3s/S547-S558 2026-04-13T05:54:26.264751+00:00 Development and Validation of RP-HPLC Method for Quantification of Total, Free and Entrapped Ritonavir in Lipid Nanocarriers and Drug content of Film Coated Fixed Dose Formulation 2022-09-28 10.5530/ijper.56.3s.164 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-547.pdf Aim: The current study was aimed to develop and validate a simple isocratic, precise, sensitive, accurate and robust reverse phase HPLC analytical method for the quantification of total, free and entrapped ritonavir in lipid nanocarriers and drug content of the filmcoated fixed-dose formulation. Materials and Methods: The method was developed by using Inertsil ODS-3V C18 column as stationary phase, orthophosphoric acid (OPA) in water (pH 3.0) and acetonitrile as mobile phase. Further, the method HPLC method, Ritonavir, Validation, SPE, NLC, Bulk formulation https://www.ijper.org/preparation-and-characterization-of-azithromycin-loaded-solid-dispersion-a-new-a 2026-04-27T11:27:46.772467+00:00 Preparation and Characterization of Azithromycin Loaded Solid Dispersion: A New Approach to Enhance in vitro Antibacterial Activity 2022-09-28 10.5530/ijper.56.3s.151 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-432.pdf Aim: Azithromycin (AZ) possess high permeability but low solubility in gastrointestinal (GI) fluid and exhibited unpredictable dissolution profile resulting in poor oral bioavailability. Therefore, the study was aimed to enhance the dissolution rate of AZ and evaluation of its in-vitro antibacterial activity. Materials and Methods: Solid dispersions of AZ (ASDs) were prepared by solvent evaporation technique using Na-CMC alone or in combination with Carplex-80 as carrier in different ratios. Sub Solid dispersion, Azythromycin, Hydrophilic carrier, In-vitro dissolution, Physicochemical characterization, Antibacterial activity https://www.ijper.org/article/56/3s/S559-S569 2026-04-27T11:31:52.98563+00:00 Comprehensive Bibliometric Overview of Research Trends of Indian Journal of Pharmaceutical Education and Research 2022-09-28 10.5530/ijper.56.3s.165 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-559.pdf In this study, we have examined the research trends of the Indian Journal of Pharmaceutical Education and Research for the year 2008-2020. We have used bibliometric indicators in two ways on the 1261 documents published in the journal. First, we have presented the performance analysis of the journal, like year-wise distribution of documents, authorship pattern, prolific authors, institutions, and countries. Secondly, the science mapping like keyword analysis, country collaboration, etc., was don Bibliometric, Journal Analysis, Science Mapping, Performance Analysis https://www.ijper.org/article/56/3s/S581-S598 2026-04-27T11:34:20.457447+00:00 An Overview of Nanoparticle Drug Delivery for Ototoxin and Noise Mediated Hearing Loss Treatment 2022-09-28 10.5530/ijper.56.3s.167 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-581.pdf Efficient delivery of therapeutic material to target site of the inner ear is considered as the most challenging process due to their poor blood flow and inaccessibility sensitivity towards chemical stimuli, inability of drug to be delivered as well. Novel nanoparticlebased drug transport approaches have emerged for overcoming the restriction associated with inner ear therapeutic material delivery. The main focus of this article is to highlight the potential benefits, pre-clinical level otoprote Nanocarriers, Otoprotective agents, Sensorineural heating loss, Ototoxicity, Noise trauma, Ototoxin https://www.ijper.org/article/56/3s/S469-S478 2026-04-13T05:54:26.264751+00:00 Bioactive Compounds of Schefflera stellata (Geartn.) Baill. Leaf Methanolic Extract and their Cytotoxic Effect on Lung cancer Cell Line (A549) 2022-09-28 10.5530/ijper.56.3s.155 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-469.pdf Objectives: The present study was focused on the fractionation and isolation of biologically active plant secondary metabolites from methanol leaf extract of Schefflera stellata (Geartn.) Baill. and their cytotoxic effect were evaluated by performing an MTT assay over the Lung cancer cell line (A549). Materials and Methods: Bioactive molecules were fractioned and purified using Column and TLC. Purified constituents exhibit its antioxidant property by dot plot assay using DPPH method. The cytotox Schefflera stellata, GC-MS, Cytotoxic activity, Dot plot assay, DPPH, Lung, Cancer https://www.ijper.org/article/56/3s/S462-S468 2026-04-13T05:54:26.264751+00:00 Evaluation of Chronic Constriction Injury Induced Neuropathic Pain Using Chrysin in Rats 2022-09-28 10.5530/ijper.56.3s.154 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-462.pdf Introduction: The exhaustive literature review suggested the vast pharmacological profile of chrysin but this drug has not been scientifically reported in the healing of nerve pain till date. The nerve pain is linked with various diseases such as cancer, inflammation, diabetic and mental problems. Neuropathic pain has been viably prompted in rodents by chronic constriction injury (CCI) of sciatic nerve. Objectives: The natural phytoconstituent chrysin will be investigated for neuropathic pain us Biomarker, Chrysin, Flavonoid, Gabapentin, Neuropathy, Pain https://www.ijper.org/improved-impact-factor-for-ijper 2026-04-27T11:25:11.46944+00:00 Improved Impact Factor for IJPER 2022-09-28 10.5530/ijper.56.3s.144 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-374.pdf Dear Audience, The Impact Factor (IF) is a popular metric used by researchers to measure the impact of journal articles. IF is calculated as the number of citations received by a journal in the period between the date of publication and the end of the year, divided by the number of articles published in that journal during that period. The higher the IF, the more influential the journal is. Nowadays, most journals publish their results online as well, making it easier for researchers to get acc Editorial https://www.ijper.org/cefuroxime-axetil-loaded-dispersed-formulation-for-enhanced-drug-release-and-ant 2026-04-13T05:54:26.264751+00:00 Cefuroxime Axetil Loaded Dispersed Formulation for Enhanced Drug Release and Antibacterial Activity 2022-09-28 10.5530/ijper.56.3s.153 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-454.pdf Aim: Aqueous solubility of drugs is a determining factor for bioavailability in systemic circulation and confronts in the unbeaten formulation of therapeutic agents. Cefuroxime axetil (CA) is a broad-spectrum β-lactamase cephalosporin that pertains to class II drugs under Biopharmaceutical Classification System (BCS) with poor aqueous solubility and high absorption permeability after oral administration. The objective of this current work was to achieve the enhanced solubility in water and subse Cefroxime axetil, Coarse dispersion, Solubility, Dissolution, Antibacterial, activity https://www.ijper.org/biological-evaluation-of-mercurialis-annua-extracts-for-possible-antioxidant-ant 2026-04-13T05:54:26.264751+00:00 Biological Evaluation of Mercurialis annua Extracts for Possible Antioxidant, Antiproliferative and Cytotoxic Activity 2022-09-28 10.5530/ijper.56.3s.156 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-479.pdf Background: Mercurialis annua has been traditionally used by native people for its diuretic, laxative, antiemetic and antioxidant activity in addition to its usefulness in the treatment of warts, eye problems and microbial infections. Aim: The goal of this work is to study the different extracts of aerial parts of Mercurialis annua collected from the Jordan territories and test them for possible antioxidant, cytotoxic and antiangiogenic activities. Materials and Methods: One kilogram of the drie Mercurialis, Antiangiogenic, Quercetin, Antioxidant, Cytotoxic https://www.ijper.org/impact-of-artificial-intelligence-ai-on-drug-discovery-and-product-development 2026-04-13T05:54:26.264751+00:00 Impact of Artificial Intelligence (AI) on Drug Discovery and Product Development 2022-09-28 10.5530/ijper.56.3s.146 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-387.pdf Artificial Intelligence (AI) had transfigured different sectors in society, where the pharmaceutical sector is not an exceptional case. Pharmaceutical sectors have reached new heights with the emergence of these sophisticated technologies. The evolution of artificial intelligence in the pharmaceutical industry is in a growth phase opening the possibilities of discovering many new drugs. The diseases affecting humans are increasing tremendously whereas the drugs which are available to treat or cu Drug discovery, Drug delivery, Machine learning, Era of machines, Algorithm https://www.ijper.org/magnetite-fe3o4-nano-oxide-from-aqueous-leaf-extract-of-coccinia-grandis-l-voigt 2026-04-13T05:54:26.264751+00:00 Magnetite Fe3O4 Nano-oxide from Aqueous leaf Extract of Coccinia grandis (L.) Voigt: Synthesis, Characterization, Magnetic studies and Anti-cancer Evaluation 2022-09-28 10.5530/ijper.56.3s.160 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-508.pdf Aim: To synthesize and investigate the anticancer activities of the metal nanoparticles derived from the ethanolic solution of the Coccinia grandis (L.) Voigt leaves. Background: Coccinia grandis (Ivy gourd) belongs to the Cucurbitaceae family is known for its own significance especially in conventional medicines, including Indian Ayurveda. Materials and Methods: The title iron oxide nanoparticles from Coccinia grandis leaf extract has been synthesized as reported in the literature and character Magnetite, Anti-Cancer, Metal nanoparticle, VSM, Coccinia grandis https://www.ijper.org/hemidesmus-indicus-var-pubescens-root-ameliorates-dextran-sodium-sulfate-induced 2026-04-13T05:54:26.264751+00:00 Hemidesmus indicus var. pubescens Root Ameliorates Dextran Sodium Sulfate-induced Ethanol Augmented Ulcerative Colitis in Rats 2022-09-28 10.5530/ijper.56.3s.157 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-487.pdf Aim: Ulcerative colitis is a chronic, idiopathic, inflammatory condition of the colon. Studies have indicated that Hemidesmus indicus var. pubescens root extract possess antioxidant and antiulcerogenic activity. In this study, we aimed to evaluate the therapeutic effect of Hemidesmus indicus var. pubescens aqueous root extract in Dextran Sodium Sulfate induced, ethanol augmented ulcerative colitis in Wistar rats. Materials and Methods: The animals were administered with 2% Dextran Sodium Sulfate Dextran Sodium Sulphate – Ethanol, Hemidesmus indicus var. pubescens, Indian sarasaparilla, Ulcerative colitis, Inflammatory Bowel Disease https://www.ijper.org/formulation-and-evaluation-of-oral-trans-mucosal-delivery-system-of-eletriptan-h 2026-04-13T05:54:26.264751+00:00 Formulation and Evaluation of Oral Trans-mucosal Delivery System of Eletriptan Hydrobromide 2022-09-28 10.5530/ijper.56.3s.149 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-413.pdf Background: To formulate, develop and evaluate sublingual tablet of anti-migraine agent (Eletriptan Hydrobromide). Materials and Methods: The sublingual tablet was prepared by direct compression method and the tablets were formulated using Kyron T-314, Sodium Bicarbonate, Mannitol, Neusilin US2, Stevia, PVP K-30, Magnesium Stearate and Talc as excipients. The prepared tablets were evaluated for various parameters like hardness, thickness, friability, weight variation, wetting time, in vitro disi Anti-Migraine, Alkalizing agent, Permeation, Sublingual, Eletriptan, Hydrobromide https://www.ijper.org/functional-role-of-novel-anthranilic-acid-derivatives-as-anti-inflammatory-agent 2026-04-13T05:54:26.264751+00:00 Functional Role of Novel Anthranilic Acid Derivatives as Anti-inflammatory Agents 2022-09-28 10.5530/ijper.56.3s.162 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-522.pdf Background: The discovery of new cyclooxygenase (COX) inhibitors with high efficacy and safety would greatly aid in developing anti-inflammatory drugs. This study evaluated the anti-inflammatory activity and the expected side effect of two synthesized anthranilic acid derivatives (JS-3 and JS-4). Materials and Methods: The COX selectivity of compounds was assessed in a whole blood assay. The results were confirmed by molecular docking studies. In vivo anti-inflammatory activity was tested in com Cyclooxygenase inhibitors, Anthranilic acid derivatives, Mefenamic acid, Rheumatoid arthritis, Anti-inflammatory, Safety evaluation, Molecular docking https://www.ijper.org/article/56/3s/S605-S612 2026-04-13T05:54:26.264751+00:00 Development and Characterization of Cinnamon Oil- Salicylic Acid Blended Nanoemulsion (CSN) for topical Application 2022-09-28 10.5530/ijper.56.3s.169 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-605.pdf Background: This study aimed to develop and describe a Cinnamon Oil-Salicylic Acid Blended Nanoemulsion (CSN) for topical use. Different ratios of oil, surfactants, and water were used to create the base for the nanoemulsions. Methods: To determine the nanoemulsion (NE) base regions, pseudo ternary phase diagrams were created. In addition, nine formulations containing mixes of Tween 80 and ethanol were examined for their droplet size, zeta potential, viscosity, pH, microscopy and spectroscopic t Drug release, Permeation, Stability, Skin disorder https://www.ijper.org/article/56/3s/S444-S453 2026-04-13T05:54:26.264751+00:00 Drug Bioavailability, Stability and Anticancer Effect of Berberine-loaded Magnetic Nanoparticles on MDA-MB-231 Cells in Breast Cancer 2022-09-28 10.5530/ijper.56.3s.152 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-444.pdf Introduction: Breast cancer is the most causative factors of death in women. Treatment often consists of surgery, radiation therapy, and chemotherapy, have several side effects. Berberine is an alkaloid naturally-derived from Berberis aristata and a family Berberidaceae exhibits a broad spectrum of pharmacological benefits, including antiviral and anticancer properties etc. The recent development of nanomedicine is an art of delivering drugs to the target-site by improving their safety and effic Co-precipitation Method, FTIR, HRSEM, VSM, Loading efficiency, Stability, In-vitro release study, In-vitro anti-cancer study https://www.ijper.org/article/56/3s/S599-S604 2026-04-13T05:54:26.264751+00:00 LC-ESI-MS/MS Method for the Fosamprenavir Quantification Bioanalytical Method Development and Validation for the Quantification Fosamprenavir in Human Plasma by LC-ESI-MS/MS 2022-09-28 10.5530/ijper.56.3s.168 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-599.pdf Objectives: The main goal of the current research was to develop a bioanalytical technique for the quantification of fosamprenavir in plasma by LC-ESI-MS/MS. Materials and Methods: Chromatographic elution was attained thru a Zorbax (3.5 μm; 50×4.6 mm) analytical C18-column with isocratic system by methanol, 0.1%v/v formic acid and acetonitrile in the ratio of 60:10:30 V/V as mobile phase with flowrate of 0.70 ml/ min. Liquid-liquid extraction was executed for the drug separation with an ethyl ac Fosamprenavir, Protease inhibitor, LC-MS/MS, FDA guidelines, Acuuracy https://www.ijper.org/article/56/3s/S407-S412 2026-04-27T11:26:05.153352+00:00 Formulation and Characterization of Chrysin Loaded Phytosomes and its Cytotoxic Effect against Colorectal Cancer Cells 2022-09-28 10.5530/ijper.56.3s.148 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-407.pdf Background: Chrysin is a phytoconstituent which has anticancer activity. The study aims to formulate, characterize and evaluate the cytotoxic effect of chrysin loaded phytosomes against HT29 cells. Materials and Methods: Antisolvent precipitation technique was employed to prepare phytosomes. Particle size, polydispersity index, zeta potential, entrapment efficiency, scanning electron microscope and Fourier transform infrared spectroscopic analysis were carried out for the characterization of chr Chrysin, Phytoconstituent, Nanoformulation, Colorectal cancer, Cytotoxicity https://www.ijper.org/article/56/3s/S422-S431 2026-04-13T05:54:26.264751+00:00 Citric Acid Topical Lecithin Pluronic Organogel used as Anti-skin ageing: Development and Characterization 2022-09-28 10.5530/ijper.56.3s.150 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-422.pdf Background: Skin aging is one of the main issues related with skin as each part of body ages with the time, So, to avoid this problem a novel formulation was designed in which citric acid as exfoliating agent will entrapped in thermodynamically stable, lecithinbased pluronic organogels. Objectives: The basic purpose of the study is to formulate a non-irritating and biocompatible citric acid loaded lecithin pluronic organogel for the treatment of skin aging. Materials and Methods : All the eight Citric Acid, Pluronic Lecithin Organogel, Skin Aging, Topical Delivery, Primary, Irritation Index https://www.ijper.org/an-insight-into-cellular-and-molecular-changes-associated-with-cigarette-smoking 2026-04-13T05:54:26.264751+00:00 An Insight into Cellular and Molecular Changes Associated with Cigarette Smoking: A Review 2022-09-28 10.5530/ijper.56.3s.145 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-376.pdf Cigarette is a mixture of chemicals in which the major component is nicotine. Nicotine results in addiction and its effects are initiated by damaging lipids, activating oxidative sensitive pathways, DNA and other components of the cell. Long-term use of cigarettes causes both stimulatory and inhibitory responses of various cells involved in the secretion of chemokines and cytokines which are known inflammatory markers. In the smoke, particulate phases of cigarettes and smoke consumption causes o Cigarette smoking, Reactive Oxygen Species, Oxidative stress, Nitrosative, stress, free radicals, Heme oxygenase-1 https://www.ijper.org/article/56/3s/S398-S406 2026-04-13T05:54:26.264751+00:00 Exploring Machine Learning Models for Recurrence Prediction in Lung Cancer Patients 2022-09-28 10.5530/ijper.56.3s.147 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-398.pdf Background: A proper assessment for the probability of recurrence in lung cancer is mandatory for a clinician to make an effective treatment-decision. Materials and Methods: Here, we employed machine learning algorithms to predict the lung cancer recurrence rate using the Caribbean and few white ethnicities populations. A 100 metastatic record with 15 predictor variables and 1 dependent variable was considered for model development. These models were evaluated using seven performance metrics, in chine learning, Lung cancer, Recurrence, Statistical analysis, Correlation, matrix https://www.ijper.org/in-silico-studies-synthesis-and-antioxidant-studies-of-different-substituted-7-p 2026-04-13T05:54:26.264751+00:00 In-silico Studies, Synthesis and Antioxidant Studies of Different Substituted 7-Phenyl-5-(Thiophen-2-Yl)- 2-Thioxo-2,3-Dihydropyrido[2,3-D]Pyrimidine-4(1h)- Ones 2022-09-28 10.5530/ijper.56.3s.163 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-535.pdf Background: Free radicals and ROS which are formed in normal physiological conditions, damages the cells if it is not eliminated by endogenous system which causes oxidative stress. Pyridopyrimidines are important molecule in heterocyclic chemistry, gaining interest because of their biological and pharmacological activities, especially for their potential anti-tumor, antibacterial and tyrosine kinase inhibitors, among other pharmacological properties along with anti-oxidant properties. Materials Pyridopyrimidines, Thiophene, In-silico, Synthesis, Anti-oxidant https://www.ijper.org/article/56/3s/S503-S507 2026-04-13T05:54:26.264751+00:00 Antidepressant Activity of Different Fractions of Cassine albens in an Olfactory Bulbectomized Mouse Model 2022-09-28 10.5530/ijper.56.3s.159 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-503.pdf Background: Tribal peoples in north Maharashtra used Cassine albens for a range of illnesses, including some psychosomatic conditions. For treatment, these indigenous people employed a very raw form of this plant. The goal of this study is to test the traditional claims of antidepressant effect in an olfactory bulbectomized mice using a chloroform and ethyl acetate fraction of Methanolic extract of C. albens. Materials and Methods: For 28 days, olfactory bulbectomized mice were administered Ethy Olfactory bulbectomy, Splash test, Immobility period, Open Field, Forced swim test, number of line crossing https://www.ijper.org/cobalt-and-iron-based-heteroleptic-complexes-of-imidazole-synthesis-antibacteria 2026-04-13T05:54:26.264751+00:00 Cobalt and Iron-based Heteroleptic Complexes of Imidazole: Synthesis, Antibacterial and Hemolytic Potential 2022-09-28 10.5530/ijper.56.3s.161 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-515.pdf Transition metal complexes can deliver exciting properties in the development of metalbased drug system. The aim of current study is to synthesis of metal complexes and to evaluate their biological properties such as antibacterial and hemolytic activity to know their biological importance. Five cobalt and iron-based complexes (1-5), [CoII(imiH)(benz) (N3)] (1) [FeII(imiH)(piv)(N3)] (2), [FeII(imiH)(benz)(N3)] (3), [FeII(imiH)(N3)2] (4), [FeII(imiH) (piv)2] (5), (where imiH = imidazole, piv = piv Transition metal complexes, Carboxylates, Imidazole, Sodium azide, Biological, studies https://www.ijper.org/indian-pharmacists-contemplation-on-board-of-pharmacy-specialties-certification 2026-04-27T11:33:45.168081+00:00 Indian Pharmacists Contemplation on Board of Pharmacy Specialties Certification: A Multi-Centric Survey 2022-09-28 10.5530/ijper.56.3s.166 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-570.pdf Background: The Board of Pharmacy Specialties (BPS) ensures the pharmacist to be a skilled and trained healthcare professional that serves the advanced medical requirements. Our study identified the awareness and attitude of Indian pharmacist towards BPS board certification and explored their constraints and motivational elements in pursuing the credential. Materials and Methods: The cross-sectional observational study was performed with Indian pharmacists working in their homeland and those who Attitude, Awareness, Barriers, BPS, Certification, Pharmacist https://www.ijper.org/article/56/3s/S496-S502 2026-04-27T11:29:52.256389+00:00 Microflora in Rats Metagenomic Analysis of Intestinal Microflora in Rats Treated with Ellagic Acid and Sinapic Acid Using 16 S rDNA Gene Region 2022-09-28 10.5530/ijper.56.3s.158 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3s-496.pdf Background: The correct functioning of the intestinal mechanism is essential for human health. In particular, the micro ecosystem of the gut has a vital role in the development of the host and the continuity of metabolism. For this reason, many studies have been conducted on the intestinal microbiota. Today, the use of phenolic compounds in the production of complementary and alternative medicines is quite common. Purpose: In our study, changes in intestinal microflora at the species level were Gut microbiota, Metagenome, Ellagic acid, Sinapic acid, 16 S rDNA https://www.ijper.org/article/56/4/924-937 2026-04-13T05:54:24.624686+00:00 Recent Advances and Appropriate Use of Niosomes for the Treatment of Skin Cancer 2022-09-18 10.5530/ijper.56.4.170 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-924.pdf Both melanoma and non-melanoma are the most common types of skin cancers affecting various populations across the globe. Skin malignancy is more prevalent among Caucasian populations. Non-melanoma types of skin cancers are further classified as basal cell and squamous cell carcinomas, respectively. The incidence of non-melanoma type of cancers is relatively higher than melanoma type of skin cancers. Recently published data shows that melanoma of the skin stands as the seventeenth most common typ Niosomes, Drug carrier, Skin cancer, Penetration enhancer, Dosage form, Drug delivery, Drug therapy, Cancer treatment https://www.ijper.org/article/56/4/1031-1043 2026-04-13T05:54:24.624686+00:00 Essential Oils Enriched Self-nano-emulsifying Systems for Effective Oral Delivery of Zaleplon for Improvement of Insomnia Treatment 2022-09-18 10.5530/ijper.56.4.184 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1031.pdf Background: Insomnia is usually associated with mental and physical daytime impairment. Zaleplon (Zp) is indicated in insomnia management but its limited aqueous solubility led to its low bioavailability (BAV) ~30%. Self-nanoemulsifying drug delivery system (SNEDDS) was a recommended nano-delivery system for improvement poorly soluble drugs’ oral bioavailability. Consequently, this study aimed to prepare SNEDDS entrapped Zp using essential oils (EOs) have insomnia management effect. Materials an Nanoparticles, Zaleplon, Essential oils, Insomnia, SNEDDS https://www.ijper.org/discovery-of-potential-inhibitors-of-mycobacterium-tuberculosis-ethr-using-struc 2026-04-13T05:54:24.624686+00:00 Discovery of Potential Inhibitors of Mycobacterium tuberculosis EthR Using Structure and Ligand Based in silico Approaches 2022-09-18 10.5530/ijper.56.4.193 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1115.pdf Aim and Background: Mycobacterium tuberculosis (TB) remains the leading cause of human death posing one of the most serious threats to public health around the world. New strategies need to be developed to combat the growing danger by multidrug resistance. The present study aims to screen three different compounds inhibiting the binding pocket of Regulatory Repressor Protein EthR of Mycobacterium tuberculosis. In this study we performed pharmacophore modeling based virtual screening to identify Mycobacterium tuberculosis, Pharmacophore, Molecular Docking, Virtual, Screening, Molecular Dynamic Simulations, Inhibitors https://www.ijper.org/formulation-development-and-optimization-of-famotidine-mucoadhesive-tablets-by-c 2026-04-13T05:54:24.624686+00:00 Formulation Development and Optimization of Famotidine Mucoadhesive Tablets by Central Composite Design 2022-09-18 10.5530/ijper.56.4.185 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1044.pdf Objectives: The intention of present study is to formulate and optimize the famotidine mucoadhesive tablets y using Central Composite Design. Materials and Methods: The concentrations of Cordia dichotoma fruit mucilage powder (X1) and Polyvinyl pyrrolidone (X2) were demonstrated as independent variables. Whereas, the dependent variables were selected such as an in vitro Mucoadhesion Time and percentage Drug Release. The model was considered to be nonlinear and the curvature effect was significan Optimization, Central Composite Design, Drug Release, Famotidine, Muco, adhesive https://www.ijper.org/the-prevalence-of-anemia-and-hematological-findings-in-covid-19-patients-in-saud 2026-04-13T05:54:24.624686+00:00 The Prevalence of Anemia and Hematological Findings in COVID-19 Patients in Saudi Arabia 2022-09-18 10.5530/ijper.56.4.204 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1226.pdf Objectives: The aim of this study was to estimate the prevalence of anemia among COVID-19 patients in Saudi Arabia and evaluate their hematological parameters. Materials and Methods: A descriptive, cross-sectional, hospital-based study was conducted between February 2021 to March 2021, data collection covered the period between September 2020 to March 2021. All the patients were hospitalized for confirmed COVID-19. Results: A total of 6048 COVID-19 patients included in our study, 2358 (48.9%) we Anemia, Polycythemia, COVID-19, Hematological factors, CBC https://www.ijper.org/article/56/4/950-958 2026-04-13T05:54:24.624686+00:00 Indian Pharmaceutical Product Protection by Utilizing Intellectual Property Rights 2022-09-18 10.5530/ijper.56.4.175 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-950.pdf Background: Intellectual property rights (IPR) are described as concepts, creations, especially artistic endeavors around which the community is ready to confer the position of ownership. There are various sorts of intellectual property protection such as patents, copyright, trademarks, and so on. A patent is an acknowledgment of an innovation that meets the standards of worldwide uniqueness, non-obviousness, as well as commercial use. It is required for improved identifying, organizing, marketi Drug protection, Intellectual property, License, Patent, Pharmaceutical, protection, IPR https://www.ijper.org/article/56/4/1206-1218 2026-04-13T05:54:24.624686+00:00 Development and Validation of a Stability-indicating Method for Neostigmine Bromide: Separation, Identification and Characterization of Degradation Product using LC-MS and ESI-Q-TOF-MS/MS 2022-09-18 10.5530/ijper.56.4.202 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1206.pdf Objectives: Forced degradation study of the drug product and drug substance is very much important in drug development and drug discovery to establish the intrinsic stability and understand its behaviors towards different stress conditions. In the present work, stress testing of neostigmine bromide (NBr) was carried out as per ICH guidelines to identify and characterize the degradation product (DP) formed. Materials and Methods: According to ICH guidelines, drug substance was subjected to variou Neostigmine bromide, RP-UPLC, Stability-indicating, Stress study, Validation https://www.ijper.org/co-administration-of-coenzyme-q10-and-hmg-coa-reductase-inhibitor-attenuates-oxi 2026-04-13T05:54:24.624686+00:00 Co-administration of Coenzyme Q10 and HMG-CoA Reductase Inhibitor Attenuates Oxidative Stress, TGF-β, TNF-α, Nitrite Content and MPO Levels against Experimentally-induced Diabetic Nephropathy in Rats 2022-09-18 10.5530/ijper.56.4.190 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1091.pdf Objectives: Diabetes is a major disease that causes a tremendous economic burden internationally. To tackle this horrible condition, good therapeutic intervention with nutraceutical is required. These include diabetic nephropathy, which ranges from chronic kidney disease to end-stage renal failure. Thus, this study used nutraceutical such coenzyme Q10 and HMG-CoA reductase inhibitor (rosuvastatin) to see how beneficial they are in treating diabetic nephropathy. Materials and Methods: The animal Diabetic nephropathy, MPO activity, TNF-α, TGF-β, Coenzyme Q10 https://www.ijper.org/article/56/4/907-916 2026-04-13T05:54:24.624686+00:00 Professional Master of Pharmacy Education in China 2022-09-18 10.5530/ijper.56.4.172 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-907.pdf Background: The Professional Master of Pharmacy (M. Pharm.) education program in China has undergone 10 years of development and has rapidly achieved great progress. The aim of this study was to summarize and introduce the development of M. Pharm. education in China. Materials and Methods: The data related to M. Pharm. education in China was obtained from literature retrieval, the Ministry of Education of the People’s Republic of China (MOE), and related university websites. Some data was obtain Professional master of Pharmacy, Education Program, Cultivation Model, Present and Future, China https://www.ijper.org/amelioration-of-hepato-renal-impairment-by-natural-chelators-in-lead-induced-poi 2026-04-13T05:54:24.624686+00:00 Amelioration of Hepato-renal Impairment by Natural Chelators in Lead-induced Poisoning in Rats 2022-09-18 10.5530/ijper.56.4.194 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1123.pdf Background: Hepato-Renal impairment refers to renal dysfunction in a liver compromised state concerning lead metal exposure. Natural chelators (marine source) have potent chelating properties claiming to ameliorate hepato-renal dysfunction in heavy metal toxicity Material and Methods: A total of 42 male albino Wistar rats weighing between 200 to 250 g were categorised into seven groups (n=6). Except for the first group (control), which received sodium-acetate (1,000 mg/L in drinking water), all Lead Toxicity, Nephrotoxicity, Chitosan, Chitosamine, Chelation, Atherogenic, indices, Oxidative Stress https://www.ijper.org/design-and-development-of-dual-functional-colon-targeted-eudragitchitosan-nanopa 2026-04-13T05:54:24.624686+00:00 Design and Development of Dual Functional Colon Targeted Eudragit/Chitosan Nanoparticles: A QbD Approach 2022-09-18 10.5530/ijper.56.4.187 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1063.pdf Aim: The goal of this study was to develop colon-targeted nanoparticulate systems of the anti-inflammatory agent Quercetin (QU) and evaluate the formulation for various parameters that would allow the active ingredient to be released at a predetermined time and location with better pharmaceutical and therapeutic properties. Materials and Methods: Quercetin-loaded chitosan nanoparticles were formulated for this purpose using the ionic gelation method by employing Central Composite Design. To coat Anti-inflammatory agent, Ionic gelation method, Central composite design, Quercetin loaded chitosan nanoparticles, Eudragit S 100, Colon targeting https://www.ijper.org/evaluation-of-ph-dependent-solubility-and-examination-of-variation-in-pharmacoki 2026-04-13T05:54:24.624686+00:00 Evaluation of pH Dependent Solubility and Examination of Variation in Pharmacokinetic Properties of Alectinib: A Quantitative Study by Implementing Integrated Quality by Design Approach for RP-HPLC Method Development and Optimization 2022-09-18 10.5530/ijper.56.4.203 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1219.pdf Introduction: Alectinib, an anaplastic lymphoma kinase inhibitor of BCS class IV, is said to have pH-dependent solubility and is susceptible to interactions with co-prescribed acid-reducing agents. Objectives: A micro-dissolution study was performed to determine the effect of modulations in gastrointestinal pH using biorelevant media and a sensitive RP-HPLC technique was developed for quantification of alectinib in the same using quality by design approach. Materials and Methods: Analytical meth Alectinib, QbD, pH, ALK kinase, Micro dissolution https://www.ijper.org/evaluation-of-anti-cancer-activities-of-cranberries-juice-concentrate-in-osteosa 2026-04-27T11:43:11.311381+00:00 Evaluation of Anti-cancer Activities of Cranberries Juice Concentrate in Osteosarcoma Cell Lines (MG-63) 2022-09-18 10.5530/ijper.56.4.195 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1141.pdf Aim/Background: Osteosarcoma is one of the prevalent cancers occurring mostly in adolescents and has a high risk of malignancy. With complications involved in the current treatment strategies, alternates including the use of phytochemicals have gained fame. Cranberries are known for their exceptional health benefits and have been explored for their effective activities in various cancers. The current study aimed at evaluating the anti-cancer properties of cranberry juice concentrate (CJC) on MG- Apoptosis, Cranberry, MG-63, Osteosarcoma, Phytochemicals https://www.ijper.org/article/56/4/917-923 2026-04-27T11:36:16.031344+00:00 Human Follicular Fluid, Clinical Use of Proteomics Analysis in Identification of Infertility 2022-09-18 10.5530/ijper.56.4.173 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-917.pdf Introduction: In present situation infertility is one of the chief problem for reproductive couples due to multiple factors including lifestyle. Infertility is thought to be caused by both male and female factors in 27 percent of cases, with 15 percent of cases being idiopathic. Assisted reproductive technologies are used by these couples to overcome the problems related to infertility, but the success rate of ART is appreciated by WHO if it reaches to 30%. About 70% non-successful ART is due to Infertility, Assisted reproductive technologies, Proteomics, Therapeutic, Management https://www.ijper.org/article/56/4/984-993 2026-04-27T11:37:57.86126+00:00 Design, Optimization, in vitro and in vivo Evaluation of Flurbiprofen Loaded Solid Lipid Nanoparticles (SLNs) Topical Gel 2022-09-18 10.5530/ijper.56.4.179 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-984.pdf Background: The aim of present study was to carry out the formulation design and evaluation of Solid Lipid Nanoparticles (SLNs) loaded topical gel of Flurbiprofen. Materials and Methods: Flurbiprofen solid lipid nanoparticles (SLNs) were formulated using Glyceryl monostearate (GMS) as lipid matrix by solvent evaporation method followed by probe sonication. A 32 full factorial design was utilized to optimize the SLNs. Drug: lipid ratio and sonication time were chosen as independent variables. Par SLNs, DoE, Flurbiprofen, Particle size, Zeta Potential, In vitro drug release https://www.ijper.org/article/56/4/959-967 2026-04-27T11:37:10.906473+00:00 Effects of Online Teaching Model of “Super Star Learning System and QQ Group” on Learning Enthusiasm and Academic Performance 2022-09-18 10.5530/ijper.56.4.176 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-959.pdf Background: Online teaching based on multiple platforms has become an important and respected teaching method. Aim: We aimed to investigate effect of “Super Star Learning System and QQ Group” online teaching model on learning enthusiasm and academic performance. Materials and Methods: An evaluation system of learning enthusiasm was established and evaluated. Students’ academic performance in online teaching group and traditional teaching group were compared. Nine variables were selected, includi Online teaching model, Learning enthusiasm, Academic performance, Super, star learning system and QQ group, Satisfaction survey https://www.ijper.org/evaluation-of-health-related-quality-of-life-among-hypertensive-post-menopausal 2026-04-13T05:54:24.624686+00:00 Evaluation of Health-related Quality of Life among Hypertensive Post-menopausal Women Using EQ-5D in India During COVID-19 Pandemic 2022-09-18 10.5530/ijper.56.4.205 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1232.pdf Background: Hypertension and menopause are interrelated factors to determine the quality of life (QOL) in women. Covid-19 was related to massive public anxiety, it is critical to know the level of influence in such pandemics on QOL. So this present study was aimed to evaluate the variables related with poor HRQOL in hypertensive post-menopausal women during Covid-19 pandemic in India. Materials and Methods: Hypertensive postmenopausal women visiting the general medicine department were recruited COVID-19, Hypertension, Post-menopausal women, QOL, EQ-5D, Anxiety https://www.ijper.org/attributes-of-private-pharmacy-school-graduates-as-care-providers-a-cross-sectio 2026-04-13T05:54:24.624686+00:00 Attributes of Private Pharmacy School Graduates as Care Providers: A Cross-sectional Study from Saudi Arabia 2022-09-18 10.5530/ijper.56.4.206 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1240.pdf Objectives: This study aimed to measure the level of preparedness of recent pharmacy program graduates to deliver patient care. Materials and Methods: A cross-sectional study was conducted using a validated self-administered online survey. Intended outcome measures of the survey instrument include the perception of 46 graduates regarding 16 patient care attributes. Results: Most graduates believe that they acquired the attributes named in this study. Gender appeared to not influence graduates’ b Patient care, Pharmacist attitude, Pharmacy education, Pharmacy graduates, Care provider, Pharmacist attributes https://www.ijper.org/evaluation-of-methanolic-extract-of-polyherbal-cream-on-dncb-induced-atopic-derm 2026-04-13T05:54:24.624686+00:00 Evaluation of Methanolic Extract of Polyherbal Cream on DNCB-induced Atopic Dermatitis in Wistar Albino Rats 2022-09-18 10.5530/ijper.56.4.198 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1164.pdf Background: Atopic dermatitis, is a multifactorial chronic inflammatory and immunological disease affecting the skin, with the serious impact on psychological and life style of the patients. Unique polyherbal combination of Aloe vera, Erngium foetidum, Passiflora edulis, Syzygium samarangense, based on established profile of relevant to anti-inflammatory, immunomodulatory and anti-oxidant property and formulated as cream for effective therapy. Materials and Methods: Wistar albino rats were induc Atopic Dermatits, Methanolic Extract of Polyherbal Cream, Gas, Chromatography-Mass Spectrometry, 2, 4-dinitrochlorobenzene, Dinitrophenyl-bovine, serum albumin, Acetone-olive oil solution https://www.ijper.org/garlic-mediated-green-synthesis-of-silver-nanoparticles-as-antifungal-agents-aga 2026-04-13T05:54:24.624686+00:00 Garlic Mediated Green Synthesis of Silver Nanoparticles as Antifungal Agents against Magnaporthe oryzae 2022-09-18 10.5530/ijper.56.4.207 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1245.pdf Background: Plant elements such as carbohydrates, lipids, flavonoids, polyphenols, enzymes, terpenoids, and alkaloids are used as reducing substance in the green production of silver nanoparticles. The strategy proved to be highly straightforward, cost-effective, and practical. Materials and Methods: The synthesis of nanoparticles was validated using optical inspection, in which the yellow colour solution became brown. UV-visible spectroscopy, XRD, FTIR analysis, and SEM were used to further cha Allium sativum, Magnaporthe oryzae, Silver nanoparticles, Conidia germination, inhibition assay, Colony growth inhibition assay https://www.ijper.org/statistically-2-level-factorial-by-design-expert-in-vitro-design-and-formulation 2026-04-13T05:54:24.624686+00:00 Statistically 2 Level Factorial by Design Expert: In-vitro Design and Formulation of Levitiracetam Extended Release Tablets 2022-09-18 10.5530/ijper.56.4.180 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-994.pdf Background: Levitiracetam is an antiepileptic medication that falls into the BCS Class I drug classification. It is used to treat specific types of seizures in adults and children with epilepsy because of its high solubility and permeability. Aim: The objective of the present study is to evaluate the extended release tablets of levitiracetam by direct compression using HPMCK100, HPMCK15and Xanthan gum/Ethyl cellulose effect of the dissolution rate by 2 level factorial designs by Design expert so Extended release, Design expert software, Levitiracetam, Direct compression, Drug release 8hr https://www.ijper.org/detection-of-novel-candidate-mutations-as-a-cause-of-steroid-resistant-nephrotic 2026-04-27T11:42:53.717159+00:00 Detection of Novel Candidate Mutations as a Cause of Steroid-resistant Nephrotic Syndrome in Children Using Next-generation Sequencing Techniques 2022-09-18 10.5530/ijper.56.4.171 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1134.pdf Background and Objectives: Steroid-resistant nephrotic syndrome (SRNS) is a serious chronic ailment that affects children and causes blood coagulation issues as well as an increased vulnerability to infections. Only around 10% of inherited genetic nephrotic syndrome cases are responding to steroid therapy, and, accordingly, 90% of SRNS patients have multidrug resistance. This study was done to detect novel candidate mutations as a factor for causing SRNS in children using the sequencing techniqu Next-generation sequencing, Steroid-resistant nephrotic syndrome, Focal, segmental glomerulosclerosis, Gene mutation, Pediatric https://www.ijper.org/bio-analytical-method-development-and-validation-for-simultaneous-determination 2026-04-27T11:44:37.001+00:00 Bio-analytical Method Development and Validation for Simultaneous Determination of Bictegravir, Emtricitabine, and Tenofovir Alafenamide Fumarate in Human Plasma by LC-MS/MS 2022-09-18 10.5530/ijper.56.4.201 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1190.pdf Aim: The current method was developed as a novel and reliable quantitative liquid chromatography-mass (tandem) spectrometry (LC-MS/MS) method for the estimation of analytes like Bictegravir (BIC) Tenofovir Alafenamide Fumarate (TNF), and Emtricitabine (EMT) in plasma of human simultaneously. Materials: Naproxen (NPX) is used as the internal standard for the current study. The ‘Precipitation Extraction technique’ is used for the present study. The Zorbax XDB C18 analytical column (2.1 X 50 and pa Bictegravir, Emtricitabine, Tenofovir Alafenamide Fumarate, Liquid, Chromatography-Mass Spectrometry, Extraction, Stability https://www.ijper.org/article/56/4/1150-1155 2026-04-13T05:54:24.624686+00:00 Proteomic Approach Reveals the Activation of Apoptosis by Padina gymnospora in Oral Cancer Cell Line 2022-09-18 10.5530/ijper.56.4.196 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1150.pdf Aim/Background: Cancer is still known to be a devastating disease condition. Even after getting advancements in multimodality therapies, the success rate with respect to patient survival is very limited. Hence there is an emerging need to find alternative medication strategies for cancer treatment. Recently seaweeds are getting their significance due to its tremendous medicinal properties. Among different category of seaweeds, Padina gymnospora which is a brown seaweed is known to possess many i Padina gymnospora, SAS oral cancer cell line, Apoptosis, 2D electrophoresis, Mass spectrometry, MTT Assay, Seaweed https://www.ijper.org/development-of-carmustine-loaded-plga-peg-conjugates-for-nose-to-brain-targeting 2026-04-13T05:54:24.624686+00:00 Development of Carmustine Loaded PLGA-PEG Conjugates for Nose to Brain Targeting 2022-09-18 10.5530/ijper.56.4.188 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1076.pdf Intranasal drug delivery is a promising route for drug delivery directly to the brain for acute or chronic treatments. A direct route to the brain offers a rapid approach to delivering drugs to the central nervous system without using the parenteral route. Carmustine is a nitrosourea used to treat brain tumors, multiple myeloma, lymphoma, and Hodgkin’s disease but its use is limited by a very little half-life in the body fluids. The nanoparticles have shown great potential to overcome problems r Nose-to-Brain delivery, Nanoparticles, Carmustine, Emulsification Solvent, Evaporation Method https://www.ijper.org/development-and-characterization-of-paliperidone-loaded-nanostructured-lipid-car 2026-04-13T05:54:24.624686+00:00 Development and Characterization of Paliperidone Loaded Nanostructured Lipid Carrier 2022-09-18 10.5530/ijper.56.4.181 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1003.pdf Background: Paliperidone is indicated for the treatment of schizophrenia. It has an absolute oral bioavailability of about 28% as it is poorly soluble in water and also undergoes hepatic first-pass metabolism. Objectives: The purpose of the present study is to improve the solubility, in vitro bioavailability of paliperidone by formulating nanostructured lipid carrier (NLC). Materials and Methods: High shear homogenization followed by the ultrasonication technique was used for the preparation of High shear homogenization, Ultrasonication, Lyophilization, Bioavailability, Stability https://www.ijper.org/evaluation-of-the-thrombolytic-and-antioxidant-activity-of-leaf-extracts-of-plum 2026-04-13T05:54:24.624686+00:00 Evaluation of the Thrombolytic and Antioxidant Activity of Leaf Extracts of Plumbago zeylanica L. 2022-09-18 10.5530/ijper.56.4.200 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1181.pdf Background: Plumbago zeylanica L. is one of the extremely accessible conventionally used herbal plants with various biological activities. However, actions of P. zeylanica L on blood clotting and other complications of blood were indisposed therapeutically studied. Therefore, the scope of the current exploration is to screen the thrombolytic, antioxidant, and cytotoxic effects of leaf extracts. Materials and Methods: Thrombolytic activity (in vitro) was assessed with clot lysis and thrombin inhi Plumbago zeylanica L, Thrombolytic activity, Anti-oxidant activity, Cytotoxicity, Streptokinase, DPPH radical etc https://www.ijper.org/quality-by-design-optimization-of-letrozole-solid-lipid-nanoparticle-for-breast 2026-04-13T05:54:24.624686+00:00 Quality by Design: Optimization of Letrozole Solid Lipid Nanoparticle for Breast Cancer 2022-09-18 10.5530/ijper.56.4.182 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1013.pdf Aim: Hormone responsive breast cancer is the most prevalent cancer worldwide. Letrozole is a third-generation aromatase inhibitor widely used for the treatment of advanced breast cancer. The primary objective of the present work is to develop and optimize an injectable solid lipid nanoparticle incorporating letrozole to circumvent the side-effects of a marketed conventional formulation and thereby improve patient compliance. Materials and Methods: Emulsification solvent evaporation and melt disp Solid lipid nanoparticle, Letrozole, Ishikawa diagram, Plackett burman design, Central composite design, Mathematical modeling https://www.ijper.org/the-inhibition-effect-of-2-methoxy-14-naphthoquinone-on-human-hepatoma-cell-line 2026-04-13T05:54:24.624686+00:00 The Inhibition Effect of 2-Methoxy-1,4- naphthoquinone on Human Hepatoma Cell Lines: A in vitro and in vivo Studies 2022-09-18 10.5530/ijper.56.4.192 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1106.pdf Background and Aim: To study the antitumor activity of 2-Methoxy-1,4-naphthoquinone (MNQ) against hepatocellular carcinoma (HCC) cells, in an attempt to fill the knowledge gap of anti-liver cancer with MNQ. Materials and Methods: Cell viability in the presence of MNQ was assessed by MTT and effect of MNQ on HepG2 cell cycle by flow cytometry. To analyze apoptosis and its molecular mechanisms, we used a combination of Hoechst 33342 staining, annexin V binding, Rhodamine 123 staining, Real-time qu 2-Methoxy-1, 4-naphthoquinone, Hepatocellular carcinoma, Apoptosis, Cell, cycle, Hematoxylin and Eosin, Antitumor mechanisms https://www.ijper.org/inhibition-of-escherichia-coli-induced-bacterial-meningitis-by-ansamycin-loaded 2026-04-13T05:54:24.624686+00:00 Inhibition of Escherichia coli Induced Bacterial Meningitis by Ansamycin Loaded Polymeric Nanoparticles 2022-09-18 10.5530/ijper.56.4.178 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-976.pdf Background: Bacterial meningitis is a serious medical disorder that should be treated as soon as possible. Aim: The effect of ansamycin as a nanoformulation on Escherichia coliinduced meningitis was investigated. Materials and Methods: By injecting Escherichia coli directly into the brains of Swiss Albino mice, an experimental meningitis model was established. Results: As expected, TNF-α, IL-6, and IL-10 secretion was stimulated, following neutrophil infiltration. Additionally, the BBB’s vasoper Escherichia coli, Bacterial meningitis, Ansamycin, polymeric nanoparticles, Improved outcomes https://www.ijper.org/animal-models-alternatives-desideratum-during-covid-19-pandemic 2026-04-13T05:54:24.624686+00:00 Animal Models Alternatives: Desideratum during COVID-19 Pandemic 2022-09-18 10.5530/ijper.56.4.174 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-938.pdf Aim: The present work aimed at the utilization of alternative animal models in research. Background: Animal models from a long time played an important role in drug and vaccine development. However, due to the limitation like logistic, scientific and regulatory the need of alternative animal models became the need of the hour. Materials and Methods: Alternative animal models are strategies which basically substitute the live models. During the COVID-19 ongoing pandemic the fast, safe and effecti In-silico, Non-animal models, Clinical trials, Alternative models, Toxicological, studies https://www.ijper.org/adhatoda-vasica-possesses-anti-microbial-activity-and-effectively-ameliorates-is 2026-04-13T05:54:24.624686+00:00 Adhatoda vasica Possesses Anti-microbial Activity and Effectively Ameliorates Ischemia Reperfusion Injury Induced by Doxorubicin through Controlling Oxidative Stress 2022-09-18 10.5530/ijper.56.4.199 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1172.pdf Background and Objectives: Myocardial ischemia is one of the leading causes deaths among cardiac pathological conditions. Doxorubicin belongs to anthracycline class of drug which is effective against a wide variety of neoplasms. However, doxorubicininduced cardiotoxicity limits the clinical utility of the drug. One of the major causes of myocardial ischemia is oxidative stress. Adhatoda vasica have been shown to possess strong anti-inflammatory during ischemia reperfusion injury induced by doxor Doxorubicin, Cardiac ischemia, Antioxidant, MRSA, Adhatoda vasica https://www.ijper.org/article/56/4/1083-1090 2026-04-13T05:54:24.624686+00:00 Face Mask Embedded with Nanoemulsion for Reducing Facial Skin Adverse Effects Caused by Prolonged Wearing the Mask during COVID-19 Management 2022-09-18 10.5530/ijper.56.4.189 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1083.pdf Background: Wearing a facemask is one of the precautionary measures for preventing coronavirus disease spread, which causes many facial skin adverse effects. Vitamin-E (TPGS) and olive oil have an efficient effect on skin moistening. Therefore, in this study, face-masks embedded with NE; prepared using olive oil and TPGS, were developed to reduce the long-wearing face mask adverse effect. Methods: Box-Behnken design was used to develop NE formulations which were physically evaluated to select th Nanoemulsions, Face-mask, Coronavirus disease virus, Olive oil, Vitamin E https://www.ijper.org/article/56/4/1025-1030 2026-04-13T05:54:24.624686+00:00 Dual-pulse Release System of Atenolol: Preparation and in-vitro Characterization 2022-09-18 10.5530/ijper.56.4.183 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1025.pdf Aim: Hypertension exhibits a circadian rhythm and drugs need to be released at the time when the blood pressure is elevated most. This elevation is pronounced at 7 pm and at 4 am. Atenolol is an anti-hypertensive drug with an absorption window mainly in the upper section of the gastrointestinal tract. The present investigation was aimed at designing floating pulsatile capsules for dual release of atenolol in the stomach for effective management of hypertension. Materials and Methods: The floatin Hypertension, Pulsatile, Floating, Lag time, Capsule, Plug layer https://www.ijper.org/team-based-learning-experience-from-a-college-of-pharmaceutical-sciences-in-unit 2026-04-13T05:54:24.624686+00:00 Team Based Learning Experience from a College of Pharmaceutical Sciences in United Arab Emirates 2022-09-18 10.5530/ijper.56.4.177 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-968.pdf Introduction: Team-Based Learning (TBL) is an active-learning methodology that has been successfully employed in various health schools’ curricula. This study assessed the perception of pharmacy students studying in a College of Pharmaceutical Sciences towards TBL with an emphasis on their perception to online TBL. Materials and Methods: The study was a cross sectional survey including students of all the four years of Bachelor of Pharmacy program. Team-based learning student assessment instrume Team-Based Learning, Pharmacy, Online, Perception, United Arab Emirates https://www.ijper.org/anti-diabetic-effect-of-sprouted-trigonella-foenumgraecum-l-seed-solid-dosage-fo 2026-04-27T11:43:51.537844+00:00 Anti-diabetic Effect of Sprouted Trigonella foenumgraecum L. Seed Solid Dosage Form in Low-dose Streptozotocin Induced Diabetic Rats 2022-09-18 10.5530/ijper.56.4.197 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1156.pdf Background: Trigonella foenum-graecum L (Fenugreek) is an annual herb, mainly cultivated for its seed as well as for its sprouts. Pharmacological investigations reported anti-bacterial, anti-diabetic, anti-cancer, anti-diarrheal, anti-hypercholesteremic, and antiinflammatory activities of Trigonella foenum-graecum L. Aim: The purpose of this study was to accentuate on formulation of granules and investigate the effect of germinated Trigonella foenum-graecum L. (TFG) granules in Diabetes mellitus Trigonella foenum-graecum, Fenugreek, Anti-diabetic, Tablet, Diabetes, mellitus https://www.ijper.org/enhanced-solubility-of-meloxicam-with-sodium-benzoate-hydrotrope-ecofriendly-app 2026-04-27T11:40:27.258851+00:00 Enhanced Solubility of Meloxicam with Sodium Benzoate Hydrotrope: Ecofriendly Approach for Improved Topical Drug Delivery 2022-09-18 10.5530/ijper.56.4.186 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-4-1052.pdf Background: Hydrotropic solid dispersion has been reported as a potential process to improve the poor solubility of drugs using conventional hydrotropes. The presented investigation has described a water-soluble hydrotropic solid dispersion system for Meloxicam (MX) using sodium benzoate hydrotrope to enhance the poor solubility of Meloxicam and to improve topical delivery. Thus, solid dispersion was prepared, characterized, and converted into HSD-Meloxicam gel. The prepared gel was further char Hydrotropes, Hydrotropic solid dispersion, Solubility, Dissolution, Topical gel, Stability studies https://www.ijper.org/article/56/3/830-837 2026-04-27T11:20:47.014199+00:00 Identification of Antioxidant and Antidiabetic Compounds in Hedychium spicatum using TLC Bioautography Coupled with Mass Spectrometry and their in silico Molecular Docking Studies 2022-06-07 10.5530/ijper.56.3.135 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-830.pdf Background: Traditional system of medicine has been practised since a long time to cure various diseases. More than 60-80 percent people across the world use herbal medicine for their health care. In the present study, TLC-MS bioautography combined with DPPH, α-amylase and α-glucosidase bioassay were used to compare antidiabetic and antioxidant activities in hydro alcoholic extracts of H. spicatum and also explore in silico molecular docking studies. Materials and Methods: In this paper, hydro-a Hedychium spicatum, TLC-bioautography, Antioxidant, Antidiabetic, in silico https://www.ijper.org/article/56/3/681-688 2026-04-27T11:16:24.241045+00:00 Floating Microspheres of Lafutidine: Formulation, Optimization, Characterization, in-vitro and in-vivo Floatability Studies Using Eudragit Grades 2022-06-07 10.5530/ijper.56.3.116 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-681.pdf Aim/Background: The objective behind this study was to develop a Microspheres of Lafuditine using central composite design for gastroretentive drug delivery. Materials and Methods: Gastroretentive Microspheres were prepared by Emulsion Solvent Evaporation method. The present investigation will study the effect of formulation variables (polymer concentration etc) on the floating behaviour and drug release characteristics for developing mathematical relationship between them and optimize the formu Lafutidine, Eudragit, Central composite design, In-vitro drug release, Microparticulate system, Sodium bicarbonate https://www.ijper.org/article/56/3/667-672 2026-04-27T11:14:30.764594+00:00 Organizing and Conducting Small Group Interactive Learning Sessions 2022-06-07 10.5530/ijper.56.3.114 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-667.pdf Interactive teaching/learning is becoming more common in medical schools. Basic science teaching is often considered dry, uninteresting, and considered by students to be not ‘directly’ relevant to their future career as practicing doctors and healers. Interactive, small group learning requires basic knowledge of facilitation skills and group dynamics. Students work together in small groups to solve problems and study in a spirit of cooperation and teamwork. Students assume more responsibility fo Basic sciences, Group dynamics, Facilitation, Interactive learning, Small, group learning https://www.ijper.org/article/56/3/899-906 2026-04-27T11:23:27.822431+00:00 India’s Incipient Comparative Advantage and Trade Specialization in Pharmaceutical Sector in Comparison to ASEAN 2022-06-07 10.5530/ijper.56.3.143 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-899.pdf Introduction: Today the whole world is looking towards the rising role of Asian nations in the world trade. Amid 48 Asian nations, India’s pharmaceutical segment observed a crucial restructuring in mounting income and occupational opportunities. Aim/ Objectives: Therefore, the present study aims at measuring comparative advantage and trade specialization between India and selected ASEAN economies at harmonized standard 4-digit level of product categorization. Materials and Methods: Statistical i Pharmaceutical Sector, India, ASEAN, Trade Specialization, Comparative, Advantage https://www.ijper.org/strategies-for-the-suitability-of-self-assembled-supramolecular-polymersomes-in 2026-04-27T11:13:14.633395+00:00 Strategies for the Suitability of Self-assembled Supramolecular Polymersomes in Drug Delivery and Diagnostics 2022-06-07 10.5530/ijper.56.3.109 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-608.pdf Amphiphilic copolymers which can self-organize into distinct nano vesicles comprising of hydrophilic core and a hydrophobic bilayer membrane with innumerable morphologies have wide applications ranging from cell mimics to diagnostics. The flexibility to control the size, shape, morphology, functionality and surface properties makes polymersomes widely acceptable. The suitability of these systems for various biomedical applications exhilarated because of its robust responsiveness to both internal Polymersomes, PEG, Amphiphiles, Payload, Stimuli https://www.ijper.org/article/56/3/846-854 2026-04-13T05:54:26.944735+00:00 Exploring Natural Compounds of Sungihwajungtang for TRPV1 Antagonistic and Anti-inflammatory Effect using in silico Method 2022-06-07 10.5530/ijper.56.3.137 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-846.pdf Background: Temporomandibular joint disorder (TMD) is a neuromusculoskeletal disorder that mainly affects the temporomandibular joint. Due to the multifactorial disease etiology inflammation and chronic pain are considered as main targets for drug design and development. Surgery and pharmacologic interventions are used to treat TMD. However, these therapies have their advantages and disadvantages and require the discovery of safer and non-invasive therapies. Natural medicinal extracts remained a Temporomandibular joint disorder, Sungihwajungtang, Medicinal Plants, Virtual Screening, in silico Gene Expression, Pharmacokinetics https://www.ijper.org/article/56/3/822-829 2026-04-27T11:20:25.064797+00:00 Protective Effects of Ficus benghalensis in Streptozotocin (STZ) Induced Diabetic Zebrafish (Danio rerio) Model 2022-06-07 10.5530/ijper.56.3.134 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-822.pdf Background: Diabetes Mellitus (DM) is a chronic metabolic disorder that is characterized by hyperglycemia. Severe complications such as cardiovascular disease, neuropathy, nephropathy, and retinopathy are associated with DM. Objectives: To explore a safer treatment option with no/less adverse effects, we evaluated the potential of Ficus benghalensis to alleviate certain diabetic conditions. Materials and Methods: Administering streptozotocin to zebrafish intraperitoneally induced diabetes. After Diabetes mellitus, Ficus benghalensis, Alkaline phosphatase, Alanine, aminotransferase, Aspartate aminotransferase, Zebrafish https://www.ijper.org/article/56/3/723-731 2026-04-27T11:17:35.222058+00:00 Formulation, Characterization, and Evaluation of Doxorubicin-loaded Cubosome as a Cytotoxic Potentiator against HCT-116 Colorectal Cancer Cells 2022-06-07 10.5530/ijper.56.3.121 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-723.pdf Background: Colorectal cancer (CRC) has grown to be the world’s fourth-biggest cause of cancer-related mortality. It is critical to identify more effective treatment options for it. Objectives: Doxorubicin a potent antineoplastic agent is widely used but has severe adverse effects. Therefore, our objective is to use cubosome as an efficient drug delivery system to reduce the off-target effects and increase the cytotoxic effects in CRC cells. Materials and Methods: Pluronic F127-Based Cubosomes w Doxorubicin, HCT-116 cells, Pluronic F127, in vitro activity, Cubosomes, Entrapment efficiency https://www.ijper.org/article/56/3/740-747 2026-04-13T05:54:26.944735+00:00 Effects of Arbutin on Fatty Acid Levels of Erythrocyte and Serum in Wistar Albino Rats Treated with Potassium Bromate 2022-06-07 10.5530/ijper.56.3.123 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-740.pdf Background: In the presented study; the Effects of Arbutin (ARB) on the Rat Erythrocyte and serum fatty acid profile which is exposed to potassium bromate (KBrO3) were investigated. Materials and Methods: In this study, 32 Wistar albino rats weighing 250-300 g were used divided into 4 groups. Groups 1: control, group 2: KBrO3 (single dose 100 mg / kg gavage), group 3: ARB (50 mg / kg / day (ip) for 5 days), group 4: KBrO3 + ARB. At the end of the 5th day, alteration of fatty acid profile in eryt Arbutin (ARB), Potassium bromate (KBrO3), Fatty acid (FA), Polyunsaturated, fatty acids (PUFA), Monounsaturated fatty acids (MUFA), Wistar Albino Rat https://www.ijper.org/article/56/3/810-815 2026-04-13T05:54:26.944735+00:00 In vitro Acetylcholinesterase Inhibitory Activity of Different Capsicum Varieties by using Chicken Brain Extract Prepared by Employing a Home Mixer-jar as an Alternative to Expensive Tissue Homogenizer 2022-06-07 10.5530/ijper.56.3.132 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-810.pdf Objectives: The present study aimed to investigate acetylcholinesterase (AchE) inhibitory activity of methanolic extract of different capsicum varieties using isolated chicken’s brain homogenate as an alternative for rodent’s brain homogenate by Ellman’s in vitro assay. In this study, we used a home mixer-jar as a substitute for the expensive tissue homogenizer to mince the chicken brain along with conventional hand motorpestle homogenization technique. Materials and Methods: This in vitro AchE Chicken brain, Mortar and pestle, Mixer jar, Neostigmine, Capsicum extracts, Acetylcholinesterase, Ellman’s assay https://www.ijper.org/article/56/3/765-771 2026-04-27T11:18:34.876129+00:00 Anticancer Activity of Grewia obtusa Fruit on HCT- 116, MCF-7, and HeLa Tumour Cells Besides Antitubercular Activity 2022-06-07 10.5530/ijper.56.3.126 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-765.pdf Background and Objectives: Considering the unexplored therapeutic potential of a plant, Grewia obtusa (G. obtusa), and the study evaluated the biological potential of fruit extract for antitubercular and anticancer activities. Materials and Methods: G. obtusa fruit extracts were obtained by a process of cold maceration with the solvents, which includes methanol, ethyl acetate, and n-hexane. The phytochemical constituents were identified in the obtained three extracts by various qualitative tests Grewia obtusa fruit, Extraction, Anticancer activity, Antitubercular activity, HeLa, HCT 116, MCF-7 https://www.ijper.org/article/56/3/628-635 2026-04-13T05:54:26.944735+00:00 Therapeutic Approaches of Nanotechnology for Epileptic Seizures: A Comprehensive Review of Current Knowledge 2022-06-07 10.5530/ijper.56.3.111 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-628.pdf Epilepsy is a chronic neurological condition in which several neurotransmitters act like neuromodulators. The symptoms of epilepsy are caused by abnormal electrical discharges in a group of neurons in the hippocampus region of the brain. This can also affect electrical impulse generation, either in the focal area or in the hippocampus region of the brain. This review aimed to develop a better understanding of the transportation of nanoparticles across the blood-brain barrier and how to enhance t Epilepsy, Nanotechnology, Drug delivery, Movement of nanoparticle, Neurodegenerative disorder https://www.ijper.org/article/56/3/795-803 2026-04-13T05:54:26.944735+00:00 Amino Acids from Urine as Possible Biomarkers for Early Detection of Vancomycin Nephrotoxicity 2022-06-07 10.5530/ijper.56.3.130 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-795.pdf Drug-induced nephrotoxicity is an important therapeutic concern, as many endogenous compounds are filtered through the kidneys for excretion into urine. Vancomycin is a drug of last resort used to treat multiple drug-resistant infections, and is primarily used in paediatrics to treat infections caused by gram-positive organisms resistant to beta-lactam antibiotics. Vancomycin is primarily (80–90%) excreted through the kidney. To identify biochemical markers useful for the early diagnosis of neph Amino acid profiling, LC-MS, Method validation, Nephrotoxicity, Targeted, analysis, Vancomycin https://www.ijper.org/article/56/3/646-666 2026-04-13T05:54:26.944735+00:00 Thiazoles: A Retrospective Study on Synthesis, Structure-activity Relationship and Therapeutic Significance 2022-06-07 10.5530/ijper.56.3.113 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-646.pdf Thiazole or 1,3-thiazole is a distinct heterocyclic compound which incorporates sulphur and nitrogen atoms. It is a vital framework present in numerous pharmacologically active compounds, be it of natural origin or of synthetic nature. Many thiazoles having antitumor and antiviral activities, originate from microbes and marine organisms. A variety of synthetic drugs, having thiazole group, like antimicrobial sulfathiazole, antibiotic penicillin, antidepressant pramipexole, antineoplastic agent b Thiazoles, Synthesis, QSAR, Molecular Docking, Biological Activity https://www.ijper.org/article/56/3/673-680 2026-04-13T05:54:26.944735+00:00 Community Service and its Learning Values: Perceptions of Undergraduate Pharmacy Students 2022-06-07 10.5530/ijper.56.3.115 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-673.pdf Introduction: Service learning is commonly incorporated into the curricula of health professions programmes to provide a platform for students to acquire competencies outside the classroom. The objectives of this study were to explore the perceptions of pharmacy students about their experience in course-based community service activities and their educational impact, as well as the contributing factors for effective implementation. Materials and Methods: Twenty semi-structured interviews were co Pharmacy Students, Community Service, Service Learning, Health Professions, Education, Professional Development https://www.ijper.org/article/56/3/706-715 2026-04-13T05:54:26.944735+00:00 Solubility Enhancement of Lawsone by Complexation with Beta Cyclodextrin 2022-06-07 10.5530/ijper.56.3.119 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-706.pdf Introduction: Lawsone is a phyto-constituent obtained from the leaves of the Lawsonia inermis. It has antibacterial, antifungal, antiviral, wound healing, antiparasitic, tuberculostatic, anti-fertility, analgesic, anti-inflammatory, enzyme inhibitory, nematicidal, anticoagulant, and protein glycation inhibitory activities. It has poor water solubility (hydrophobic), poor bioavailability, and poor dissolution characteristics. Aim: The purpose of this research is to improve the aqueous solubility Lawsone, Beta-cyclodextrin, Inclusion complexes, Kneading method, Co-precipitation method https://www.ijper.org/IndJPhaEdRes-56-3-780 2026-04-13T05:54:26.944735+00:00 Hydroalcoholic Carthamus tinctorius L. Extract Attenuates TNBS-induced Ulcerative Colitis in Mice Via Downregulation of Inflammation and Oxidative Stress 2022-06-07 10.5530/ijper.56.3.128 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-780.pdf Background: Ulcerative colitis (UC) is distinct by severe inflammation of intestinal epithelial tissue and more than 2 million people worldwide are affected with ulcerative colitis. This disease is primarily driven by oxidative stress and inflammation. Objectives: To identify a safer remedy with less/no adverse effect, we investigated the beneficial ability of Carthamus tinctorius L. extracts to alleviate multi-factorial conditions like oxidative stress, lipid peroxidation, and inflammation in T Ulcerative colitis, TNBS, Carthamus tinctorius L, Oxidative stress, Inflammation https://www.ijper.org/article/56/3/816-821 2026-04-13T05:54:26.944735+00:00 Potential of Ocimum sanctum to Inhibit the Growth of Pseudomonas aeruginosa, a Disease-causing microorganism 2022-06-07 10.5530/ijper.56.3.133 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-816.pdf Aim and Objectives: Plants are a good source of secondary metabolites, which have huge potential to kill micro-organisms. The present study aimed to evaluate the antimicrobial activity of Ocimum sanctum ethanol extract against drug-resistant and drug-sensitive strains of Pseudomonas aeruginosa (P. aeruginosa). Materials and Methods: A total of 119 strains of P. aeruginosa, 92 multidrug-resistant (MDR) and 27 pan sensitive strains were included in the study, which were isolated from different hum Antimicrobial activity, Ocimum sanctum, Tulsi, Pseudomonas aeruginosa, Plant extract, Drug discovery https://www.ijper.org/article/56/3/789-794 2026-04-13T05:54:26.944735+00:00 Carthamus tinctorius L. Inhibits Proliferation of Lung Cancer A549 Cells and Tender’s Mitochondrial Protection 2022-06-07 10.5530/ijper.56.3.129 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-789.pdf Background: Plant-based products are well-known as long-lasting chemo preventive and chemotherapeutic medicines against cancer. Objectives: The purpose of this research is to identify out how safflower extract affects A549 cells. Materials and Methods: The antiproliferative activity was determined using the Trypan blue assay, while the cytotoxicity was determined using the MTT assay. The ethidium bromide/acridine orange (AO/EB) dual staining method was used to observe the apoptotic inducing effe Safflower, Oxidative stress, Cytotoxicity, Mitochondria, Apoptosis https://www.ijper.org/article/56/3/888-898 2026-04-13T05:54:26.944735+00:00 Development and Validation of Novel and Highly Sensitive Stability-Indicating Reverse Phase UPLC Method for Quantification of Dabrafenib and its ten Degradation Products 2022-06-07 10.5530/ijper.56.3.142 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-888.pdf Objectives: Dabrafenib is used as an active pharmaceutical ingredient acts as an inhibitor of the associated enzyme B-Raf, which plays a role in the regulation of cell growth. In the current study, we focused on developing a robust, highly sensitive and stabilityindicating RP-UPLC method for estimation of DBR and its degradation products for the very first time. A stress study has been performed to demonstrate the stability-indicating capability of the method. Materials and Methods: Chromatograp Dabrafenib, RP-UPLC, Validation, Stability-indicating, Forced degradation https://www.ijper.org/article/56/3/881-887 2026-04-13T05:54:26.944735+00:00 Development and Validation of UV-spectrophotometric Method for Estimation of Gallic Acid in Acalypha indica Leaf Extract and its Cellulose Nanoparticle Formulation 2022-06-07 10.5530/ijper.56.3.141 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-881.pdf Aim/Background: Quantification of Gallic acid in the hydro-alcoholic extract of Acalypha indica and extract loaded cellulose nanoparticles is a characteristic parameter to assess the entrapment efficiency of nanoparticles. Gallic acid is one of the major phenolic acids identified in leaf extract of Acalypha indica; hence, it was chosen to be estimated. Materials and Methods: A UV spectrophotometric method was developed using distilled water as a suitable solvent system to estimate Gallic acid. T Gallic acid, UV spectrophotometer, Acalypha indica, Cellulose nanoparticles, Method validation, Leaf extract https://www.ijper.org/article/56/3/748-755 2026-04-13T05:54:26.944735+00:00 The Neuroprotective Effects of Memantine, and Curcumin after Cerebral Ischemia-reperfusion Injury in Elderly Rats 2022-06-07 10.5530/ijper.56.3.124 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-748.pdf Background: Some researches reveal that pharmacologic and phytotherapeutic agents have benefits on neurological disorders associated with the effects of reactive oxygen species. Aim: The purpose of this research was to evaluate the protective effects of curcumin and memantine in a cerebral ischemia/reperfusion model in rats. Materials and Methods: This experimental study was conducted at the Bagcilar Training and Research Hospital, Istanbul, Turkey. Rats were separated into five experimental gro Brain ischemia, Curcumin, Memantine, Oxidative injury, Reperfusion https://www.ijper.org/article/56/3/732-738 2026-04-13T05:54:26.944735+00:00 Binary Solvent-assisted Graphene Synthesis by Direct Exfoliation of Graphite Powder and its Cytotoxicity on SiHa Cell Line 2022-06-07 10.5530/ijper.56.3.122 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-732.pdf A cost-effective mass production of pristine graphene nanosheet is still an important challenge to harness its maximum potential in medical sciences. Here, we have used a binary solvent mixture of low dielectric constant (1,2,4- trichlorobenzene,ε = 2.24 and benzylamine,ε = 4.6) to produce a high quantity (0.6 mg/ml) of graphene under ultrasonication without compromising its quality. Obtained sample were characterized through XRD, UV-Vis, Raman, FT-IR, TEM-SAED, and cytopotency was evaluated on Graphene, Nanosheet, Cytotoxicity, SiHa Cell line, Biomaterial https://www.ijper.org/article/56/3/855-864 2026-04-13T05:54:26.944735+00:00 Anti-cancerous and Antioxidant activity of Pergularia daemia Inspired Zinc Oxide Nanoparticles against Lung Cancer (A549) Cell Line 2022-06-07 10.5530/ijper.56.3.138 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-855.pdf Background and Objectives: In nanotechnology, biosynthesis of nanoparticles has gained considerable attention. Development and synthesis of plant based metallic nanoparticles with improved properties and less undesirable effects have many advantages over the conventional methods. In addition to performing their intended function, these phytoantioxidant functionalized nanoparticles can protect against oxidative damage. Pergularia daemia is a therapeutic plant that has been explored and identified Pergularia daemia, Zinc Oxide Nanoparticles, A549 cell line, Anti-cancer, activity, BAX gene, PARP gene https://www.ijper.org/article/56/3/772-779 2026-04-27T11:19:05.121587+00:00 Hepato- and Nephroprotective Effects of Ethanolic Extract of Seeds of Macrotyloma uniflorum on Paracetamol-induced Hepato- and Nephrotoxicity in Rats 2022-06-07 10.5530/ijper.56.3.127 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-772.pdf Objectives: The present study is planned to investigate the hepato- and nephroprotective effects of ethanolic extract of seeds of Macrotyloma uniflorum (EEMU) on paracetamol (PCM)-induced hepato- and nephrotoxicity in Sprague-Dawley rats. Materials and Methods: Hepato- and nephroprotective effects of EEMU were studied against PCMinduced hepatotoxicity and nephrotoxicity in rats. The rats were divided in to seven groups’ viz., control, EEMU 400 mg/kg, PCM, PCM + Vitamin C 200 mg/kg, PCM + EEMU 10 Medical herbs, Nutrition, Hepatic injury, Renal failure, Toxicity https://www.ijper.org/article/56/3/697-704 2026-04-13T05:54:26.944735+00:00 Novel Glibenclamide–Phospholipid Complex for Diabetic Treatment: Formulation, Physicochemical Characterization, and in-vivo Evaluation 2022-06-07 10.5530/ijper.56.3.118 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-697.pdf Introduction: Formulation of phospholipid complex is an ideal approach to improve the solubility of poorly soluble drugs. Objectives: This study has been aimed to prepare a novel glibenclamide-phospholipid complex by using the solvent evaporation technique. Materials and Methods: Because glibenclamide is a weakly soluble medication, complexing it with phospholipids is an excellent way to enhance its solubility. The phospholipid complex of Glibenclamide was produced using the solvent-evaporation Glibenclamide, Glibenclamide–phospholipid complex, Pharmacokinetic, Oral, bioavailability https://www.ijper.org/design-of-skill-enhancement-module-for-pharmacy-students-need-of-the-hour 2026-04-13T05:54:26.944735+00:00 Design of Skill Enhancement Module for Pharmacy Students - Need of the Hour 2022-06-07 10.5530/ijper.56.3.110 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-618.pdf Skill industries, such as manufacturing and services, are growing at a rapid rate. It is estimated that there is a huge demand for skilled employees in the future. But India’s skilled workforce is very low. The country is currently facing a dual dilemma of the extreme shortage of highly-trained, high-quality work yet as non-employment of large parts of educated people with very few or no job skills. The issue of skill development in India is so relevant to demand and supply levels. The pharmaceu Skill, Curriculum, Design, Learning, Pharmacy education https://www.ijper.org/article/56/3/838-845 2026-04-13T05:54:26.944735+00:00 Estimation of Antioxidant and Cytotoxicity Activities of Extracts Obtained from the Leaves of Folk Medicinal Plant Benkara malabarica (Lam) 2022-06-07 10.5530/ijper.56.3.136 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-838.pdf Objectives: Benkara malabarica (Lam). is pharmacologically unexploited medicinal plant, used in the folklore Paliyar in India. Medicinal plant systems to treat many ailments such as cold, phlegm, stomach and body pains. The present investigation carried out with objective of finding an alternative antioxidant and cytotoxicity medicines from traditionally used medicinal plant and to provide ethnopharmacological information for its traditional usage. Materials and Methods: Petroleum ether, chlorof Paliyar, Benkara malabarica, in vitro, Antioxidant activity, Cytotoxicity https://www.ijper.org/article/56/3/865-872 2026-04-27T11:21:33.300465+00:00 Development and Validation of Stability Indicating UV-Spectrophotometric Method for the Estimation of Hesperidin in Bulk Drugs, Plant Extract, Ayurveda Formulation and Nanoformulation 2022-06-07 10.5530/ijper.56.3.139 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-865.pdf Introduction: In present work attempt has been made to develop and validate a simple and sensitive UV spectrophotometric method for estimation of Hesperidin from bulk drugs, plant extract, Ayurveda formulation and novel nanoformulation. Hesperidin is a heteropolycyclic aromatic bioflavonoid found abundance in citrus plants that has been developed into a topical nanoformulation for the treatment of anti-inflammatory activity. It has numerous anti-inflammatory, anti-cancer, and anti-arthritis effe Hesperidin, Stability indicating, UV-Spectrophotometric, Ayurveda, formulation, Nanoformulation https://www.ijper.org/article/56/3/804-809 2026-04-13T05:54:26.944735+00:00 Study on the Effect of Phaseolus vulgaris Methanol Extract on Haloperidol and Tacrine Induced Parkinsonism 2022-06-07 10.5530/ijper.56.3.131 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-804.pdf Background: Parkinson’s disease is neurodegenerative disease with no cure till now, there are treatments that can be explored to ease the symptoms of this disease, and using plant extract we explore the possibility of neutralizing the adverse symptoms and providing better quality of life to patients. Purpose: To demonstrate Anti-parkinson’s activity of Phaseolus vulgaris methanol pod extract by using behavioural models in Wister Albino rats. Materials and Methods: Animals were given Phaseolus vu Phaseolus vulgaris, Haloperidol, Tacrine, Parkinson’s disease, Levodopa, Neuroprotective, Carbidopa, Oxidative stress https://www.ijper.org/article/56/3/689-696 2026-04-13T05:54:26.944735+00:00 Utility of Different Lipids and Effect of Soya Lecithin on Sustained Delivery of Zidovudine via Biodegradable Solid Lipid Microparticles: Formulation and in-vitro Characterization 2022-06-07 10.5530/ijper.56.3.117 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-689.pdf Background: Zidovudine (Azidothymidine, AZT) is widely used in the treatment of Acquired Immuno Deficiency Syndrome (AIDS) and related conditions, either alone or in combination with other antiviral agents to combat HIV. AZT is a Biopharmaceutical Classification System (BCS) class III drug and has various disadvantages. Thus, AZT is a potential candidate for delivery via lipid-based drug delivery system. Materials and Methods: In the present work, solid lipid microparticles (SLMs) of Zidovudine Zidovudine, Azidothymidine, AIDS, Solid lipid microparticles, Tripalmitin, Trimyristin https://www.ijper.org/article/56/3/716-722 2026-04-13T05:54:26.944735+00:00 Xylometazoline Loaded Chitosan Nanoparticles: Fabrication, Optimization and Evaluation for Nasal Congestion 2022-06-07 10.5530/ijper.56.3.120 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-716.pdf Aim: The present study aims at exploring the development of xylometazoline hydrochloride loaded chitosan nanoparticles (XYL-NP) cross linked with calcium chloride for the treatment of nasal congestion. Materials and Methods: XYL-NP were prepared using different polymer like chitosan, cross linking agent calcium chloride and glacial acetic acid as a solvent enhancer using ionotropic gelation method, which was further optimized and validated by Box-Behnken Design. Further, these particles were cha Xylometazoline hydrochloride, Nasal Congestion, Chitosan, Box-Behken, Design, Calcium Chloride, Ionic gelation, Peppas-korsemeyer https://www.ijper.org/interstitial-cystitis-critical-assessment-of-current-treatment-and-opportunities 2026-04-13T05:54:26.944735+00:00 Interstitial Cystitis-Critical Assessment of Current Treatment and Opportunities for Nanodelivery 2022-06-07 10.5530/ijper.56.3.112 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-636.pdf The characteristic feature of Interstitial cystitis (IC) or bladder pain syndrome is augmented, pressure, or inconvenience in the suprapubic or bladder region. The causative factors for IC are not completely understood however certain underlying disease condition may trigger the pain. The therapy is aimed to provide symptomatic relief, and therefore, the treatment protocols have been established based on experience. Intravesical delivery of drugs has been well explored and found to be most effec IC, Bladder pain syndrome, Bladder permeability barrier, Intravesical delivery, Nanotherapeutics https://www.ijper.org/article/56/3/873-880 2026-04-13T05:54:26.944735+00:00 Development and Validation of UV-spectrophotometric Method for Estimation of Berberine Hydrochloride in Marketed Formulation and Poly Lactic Co-glycolic Acid Nanoparticles 2022-06-07 10.5530/ijper.56.3.140 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-873.pdf Aim: The objective of present investigation is to develop and validate UV-Spectrophotometric method for estimation of Berberine hydrochloride in marketed formulation and Poly lactic co glycolic acid nanoparticles. Materials and Methods: Methanol was used for the development of UV-Spectrophotometric method. Berberine hydrochloride was detected using a 422nm wavelength. According to ICH requirements, the developed method was validated in terms of, selectivity, linear range, precision, robustness, Berberine HCl, Beer’s law, Methanol, Water, Validation, Poly lactic, co-glycolic acid nanoparticles https://www.ijper.org/article/56/3/756-764 2026-04-13T05:54:26.944735+00:00 Evaluation of the Cytotoxicity, Apoptosis and Autophagy Induction by Fucoidan in Human Hepatic Adenocarcinoma Cells 2022-06-07 10.5530/ijper.56.3.125 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-756.pdf Introduction: Seaweeds are the reservoir of bioactive constituents such as proteins, polysaccharides, alkaloids, steroids and terpenoids that possess antioxidant, antiinflammatory and anti-cancerous properties. Dictyota bartayresiana is a brown seaweed with high antioxidant activity, making this species very valuable for human health. Fucoidan is the sulphated polysaccharide obtained from brown algae. Objectives: The study aimed to extract, purify and characterize fucoidan from Dictyota bartayre Dictyota bartayresiana, Radical scavenging, Polysaccharide, Antioxidant, potential, Apoptosis https://www.ijper.org/article/56/3/600-607 2026-04-13T05:54:26.944735+00:00 Dose Conversion Between Animals and Humans: A Practical Solution 2022-06-07 10.5530/ijper.56.3.108 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-3-600.pdf Selecting the most appropriate first-in-human and pharmacologically active dose for any new drugs or biologicals is a crucial step before starting a clinical trial investigation in adult healthy human subjects. Extrapolation of dose between various rodent and non-rodent animal species is critical for biomedical researchers during initial drug development. The objective of this review is to provide practical guidance on how allometric scaling based on the body surface area normalization can be ef Starting dose, Body surface area, Dose translation, Human equivalent dose, Animal equivalent dose, Interspecies dose conversion, Allometric scaling https://www.ijper.org/central-composite-design-for-the-development-and-evaluation-of-liquisolid-compac 2026-04-13T05:54:28.272173+00:00 Central Composite Design for the Development and Evaluation of Liquisolid Compacts of Glyburide 2022-05-28 10.5530/ijper.56.2s.94 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-235.pdf Background: Glyburide is an oral antidiabetic agent with a shorter half-life and is practically insoluble in water. As a result, there is a need to enhance the drug solubility with a aim to improve drug absorption via the oral route. The goal of this study was to formulate, optimize and evaluate the liquisolid tablets of Glyburide using a suitable liquid vehicle in order to enhance the solubility, and bioavailability of the Glyburide. Materials and Methods: The liquisolid compacts of Glyburide w Liquisolid technique, Glyburide, Central composite design, Aerosil200, Transcutol HP, Avicel PH-102 https://www.ijper.org/formulation-and-evaluation-of-topical-preparations-containing-pyrolytic-oil-obta 2026-04-13T05:54:28.272173+00:00 Formulation and Evaluation of Topical Preparations Containing Pyrolytic Oil Obtained from Local Biomass 2022-05-28 10.5530/ijper.56.2s.87 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-163.pdf Objectives: Pyrolytic oil of coconut shell was obtained by the fast pyrolysis method. This research aimed to identify the use(s) of pyrolytic oil in topical pharmaceutical formulations. The study included extraction of bio-oil by pyrolysis, physicochemical characterization, screening the oil for microbial activity, preformulation studies, formulation into suitable topical preparations like ointment, gel and cream, evaluation studies of the formulation and stability studies. Materials and Methods Biomass, Pyrolytic oil, Characterization, Antimicrobial activity, Topical, preparations, Evaluation https://www.ijper.org/article/56/2s/S189-S199 2026-04-13T05:54:28.272173+00:00 Development Optimization and Cytotoxicity Evaluation of Glyburide Loaded Nanostructured Lipid Carriers 2022-05-28 10.5530/ijper.56.2s.90 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-189.pdf Aim/Background: In the present study Glyburide, a hypoglycaemic agent was loaded into nanostructured lipid carriers. The solid and liquid lipid concentrations within the formulation were optimized using central composite design with two centre points augmented with a cluster of axial and factorial points (star points). Materials and Methods: The responses particle size and drug entrapment were used to optimize the concentration ratio by central composite design. The nanostructured lipid carriers Glyburide, Central composite design, MTT assay, Cell viability study, BHK -21 cell-line, Histopathological study https://www.ijper.org/research-on-pharmaceutical-product-life-cycle-management-challenges-faced-by-gen 2026-04-13T05:54:28.272173+00:00 Research on Pharmaceutical Product Life Cycle Management Challenges Faced by Generic Manufacturers for US Approval 2022-05-28 10.5530/ijper.56.2s.105 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-347.pdf Introduction: Generic drug approval before patent expiration involves patent infringement petitions due to robust Life Cycle Management (LCM) strategies followed by Branded companies. They will extend the patent period of a product after expiration through Exclusivity rights, which act as a barrier for generic companies to launch the product immediately after patent expiration. This study focused on United States (US) generic market. Materials and Methods: The research was conducted on three maj Life Cycle Management (LCM), Patents, Exclusivity, Abbreviated New Drug, Approval (ANDA), New Drug Application (NDA) https://www.ijper.org/article/56/2s/S274-S280 2026-04-27T11:05:51.051753+00:00 Epimedii folium Polysaccharide Ameliorated Glucose Metabolic Disorder in Type 2 Diabetic Mice by Regulating the SIRT1/PPARγ Signaling Pathway 2022-05-28 10.5530/ijper.56.2s.98 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-274.pdf Background and Aim: Epimedii folium is a widely used herbal medicine with numerous medicinal effects. In this study, we aimed to investigate the effects of Epimedii folium polysaccharide (EFP) in db/db metabolic disorder mice model. Materials and Methods: Studies were carried out by the db/db mice with separately receiving EFP (100 mg/ kg, 400 mg/kg) and metformin (300 mg/kg/day) for 8 weeks. Results: In the present study, we show that EFP and metformin ameliorated metabolic disorders and decrea Type 2 diabetes, Epimedii folium polysaccharide, Hyperglycemia, Oxidative, stress, Lipid metabolism https://www.ijper.org/forced-degradation-study-of-sofosbuvir-identification-of-degradation-products-by 2026-04-13T05:54:28.272173+00:00 Forced Degradation Study of Sofosbuvir: Identification of Degradation Products by LC-ESI-MS 2022-05-28 10.5530/ijper.56.2s.89 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-181.pdf Introduction: In order to establish stability indicating techniques to comprehend the degradation behavior of drug under stress environments and to establish degradation pathway for drug substance, forced degradation is a potential tool employed more frequently in pharmaceutical developments. The sole need of present research was to establish stability and forced degradation pathway profiling of sofosbuvir. Methods: The stability of sofosbuvir has been validated by RP-HPLC method, where mixture Sofosbuvir, Degradation, HPLC, LC-ESI-MS, Pathway https://www.ijper.org/article/56/2s/S152-S162 2026-04-13T05:54:28.272173+00:00 Box-Behnken Design Assisted Optimization and Standardization of Chromatographic Methodology for Quality Assessment of Metformin: Analytical Quality by Design Avenue 2022-05-28 10.5530/ijper.56.2s.86 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-152.pdf Background: Metformin (MET) is an oral antidiabetic agent falls chemically under the category of biguanides and it is effectively utilized in the management of type 2 diabetes mellitus. It is marketed in the tablet dosage form and hence quality control and assessment of MET is very much essential and important. Objectives: The objectives of present research investigation are to implement the Box-Behnken Design (BBD) in the optimization and validation of Reverse Phase-High Performance Liquid Chro Analytical Quality by Design, Box–Behnken Design, Chromatography, Metformin, Standardization https://www.ijper.org/comparative-assessment-of-the-effect-of-lemongrass-cymbopogon-citratus-ethanolic 2026-04-13T05:54:28.272173+00:00 Comparative Assessment of the Effect of Lemongrass (Cymbopogon citratus) Ethanolic Extract, Aqueous Extract and Essential Oil in High Fat Diet and Fructose Induced Metabolic Syndrome in Rats 2022-05-28 10.5530/ijper.56.2s.99 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-281.pdf Background: Lemongrass (Cymbopogon citratus) is widely used as a folklore medication for treating obesity and diabetes. The present study evaluates the comparative effect of ethanolic and aqueous extract and essential oil of lemongrass on various conditions associated with the metabolic syndrome. Materials and Methods: High fat diet and fructose (20% w/v) were given for 60 days to induce the metabolic syndrome in Wistar rats. Body weight and BMI were assessed weekly and fasting blood sugar was e C-reactive protein, Hyperlipidaemia, Insulin resistance, Lemongrass, Metabolic, syndrome, Obesity https://www.ijper.org/article/56/2s/S303-S311 2026-04-13T05:54:28.272173+00:00 Investigation of Memory Enhancing Activity of Madhuca longifolia Leaf Extract against Colchicine: An Experimental Study and Biochemical Alterations in Mice 2022-05-28 10.5530/ijper.56.2s.101 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-303.pdf Objectives: The present study aimed at investigating the protective role of Madhuca longifolia ethanolic leaf extract flavonoid fraction against colchicine induced cognitive dysfunction and oxidative damage in swiss albino mice and to estimate the biochemical alterations in mice brain. HPTLC, total flavonoid and total phenols were also estimated in the study. Materials and Methods: The analysis was conducted on a colchicineinduced model for 28 days. Morris water maze and passive avoidance paradi Madhuca longifolia, Neuroprotective, Alzheimer’s disease, Colchicine, HPTLC, Cognition https://www.ijper.org/vaccine-safety-and-surveillance-for-adverse-events-following-immunization-aefi-f 2026-04-13T05:54:28.272173+00:00 Vaccine Safety and Surveillance for Adverse Events Following Immunization (AEFI) for COVID-19 Vaccine in a Tertiary Care Hospital-Kerala 2022-05-28 10.5530/ijper.56.2s.106 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-356.pdf Introduction: The meteoric spread of COVID-19 had facilitated the researchers to develop vaccines. One among the most recommended, Covishield requires further investigations for lighting up the society towards the immunization program. The study has determined the severity and frequency of adverse event following immunization concerning the first and booster dose of the Covishield vaccine. Also, we investigated the relationship between the participant’s demographic characteristics with the adver AEFI, COVID-19, Covishield, Surveillance, COWIN https://www.ijper.org/article/56/2s/S137-S145 2026-04-13T05:54:28.272173+00:00 The Benefits and Barriers of Patenting: How Academicians and Researchers Can use their IP to Improve Research Outcomes: An Indian Perspective 2022-05-28 10.5530/ijper.56.2s.84 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-137.pdf Patent protection is the exclusive rights to protect the invention which forbid the manufacture, use, distribution or trade of the invention by others unless they get permission from the patentee. Patent is granted to those inventions which are novel, inventive and have industrial or commercial applications. In India patenting is governed under the law “Indian patents act 1970”. Recently India has become one of the top pioneers in filing of patents compared to other countries. One of the main re Patent, Types, Intellectual Property Rights, Indian patent office, Patent Laws https://www.ijper.org/article/56/2s/S312-S325 2026-04-13T05:54:28.272173+00:00 Investigation of Biological, Scolicidal and Antimicrobial Activities of the Solvent Extracts Components of Cystoseria barbata Seen off Sinop Province 2022-05-28 10.5530/ijper.56.2s.102 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-312.pdf Aim/Background: Seaweeds are unicellular or multicellular vegetative organisms and have a wide distribution. Their antitumoral, antiviral, antifungal, insecticidal, cytotoxic, and phytotoxic and antiproliferative activities were determined. The aim of the study was to investigate the biological, antimicrobial and scolicidal activities of Cystoseria barbata (C. barbata). Materials and Methods: Cystoseria barbarata was collected in appropriate quantities. Some of them were extracted by water vapor Cystoseria barbarata, Scolicidal, Antimicrobial activity, Lethal dose, Probit, analysis https://www.ijper.org/artemether-and-lumefantrine-loaded-self-nanoemulsifying-drug-delivery-system-for 2026-04-13T05:54:28.272173+00:00 Artemether and Lumefantrine Loaded Self-nanoemulsifying drug Delivery System for Enhancement of Bioavailability 2022-05-28 10.5530/ijper.56.2s.88 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-171.pdf Introduction: This study involves development and evaluation of bioavailability of oral self-nanoemulsifying drug delivery system of BCS class II and IV drugs, Artemether and Lumefantrine (AL), respectively. This fixed combination is used for treatment of drug resistant malaria. Self nanoemulsifying drug delivery system (SNEDDS) was developed due to lipophilicity of both drugs. Pseudo ternary phase diagrams were derived based on solubility of drugs in oils and surfactants for identifying self-na Artemether, Lumefantrine, Low oral bioavailability, Self-nanoemulsifying, drug delivery system, In vitro dissolution https://www.ijper.org/IndJPhaEdRes-56-2s-s146 2026-04-13T05:54:28.272173+00:00 Team-Based Learning Approach for the Delivery of Over-the-counter Module in the Faculty of Pharmacy in Jordan 2022-05-28 10.5530/ijper.56.2s.85 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-146.pdf Team-based learning is an active learning strategy that focuses on student’s engagement, development of critical thinking, and transferable skills needed in the workplace. While many pharmacy faculties around the world have applied team-based learning into their curriculums, the implementation of team-based learning into the Middle East is still in the experimental phase and poses its own challenges. This reflective statement elaborates on our experience and feedback of implementing team-based l Team based learning, Active learning, Pharmacy, OTC, Flipped classroom, Medical education https://www.ijper.org/effect-of-solutol-hs-15-and-cremophor-rh-40-on-dissolution-and-bioavailability-o 2026-04-13T05:54:28.272173+00:00 Effect of Solutol HS 15 and Cremophor RH 40 on Dissolution and Bioavailability of Nateglinide through Solid Dispersions 2022-05-28 10.5530/ijper.56.2s.96 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-253.pdf Introduction: To improve the aqueous solubility and bioavailability of nateglinide, we have earlier used poloxamer 188 and 407. Since solutol HS 15 and cremophor RH 40 are compatible and scalable polymers for industrial applications. Materials and Methods: We developed solid dispersions using these polymers. All data including Fourier transform infrared spectroscopy, differential scanning calorimetry, thermogravimetry analysis, x-ray diffraction and scanning electron microscopy suggested loss of Amorphization, Bioavailability enhancement, In vitro-in vivo correlation, Solutol HS 15, Cremophor RH 40, Pharmacokinetic https://www.ijper.org/article/56/2s/S265-S273 2026-04-27T11:05:11.647796+00:00 Acute Dermal and Ocular Irritation Testing of Herbal Shampoos in New Zealand White Rabbits 2022-05-28 10.5530/ijper.56.2s.97 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-265.pdf Aim: The objective of the presented study is to evaluate the acute dermal and ocular irritation of herbal shampoos consisting of a mixture of plant extracts. Materials and Methods: Both studies performed using New Zealand white rabbits in accordance with HICS and OECD guidelines respectively. In the cutaneous skin irritation test, erythema, eschar or edema evaluated. In the ocular irritation study, corneal opacity, area of opacity, iris, chemosis and conjunctival redness were evaluated. Results: Herbal shampoo, Ocular irritation, Acute dermal, New Zealand white rabbits, Erythema https://www.ijper.org/development-and-in-vitro-evaluation-of-atazanavir-microcrystals-for-intranasal-d 2026-04-13T05:54:28.272173+00:00 Development and in vitro Evaluation of Atazanavir Microcrystals for Intranasal Delivery 2022-05-28 10.5530/ijper.56.2s.92 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-216.pdf Background: Nasal route of drug administration has gained popularity nowadays specially for drugs acting on nasopulmonary area. Atazanavir is an antiviral drug which has proved efficacy in different viral infection including COVID-19. Therefore the hypothesis is, if given through intra nasal route this formulation will be able to prevent the viral infection like COVID-19 by directly acting on the virus at its entry point. Objectives: This study aims to prepare a stable mucoadhesive microcrystal COVID-19, Atazanavir, Protease inhibitor, Naso-pulmonary, Intranasal, Antiviral https://www.ijper.org/drug-repurposing-a-potentially-emerging-discipline 2026-04-13T05:54:28.272173+00:00 Drug Repurposing: A Potentially Emerging Discipline 2022-05-28 10.5530/ijper.56.2s.83 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-121.pdf Drug repurposing is the remodeling of already existing drugs to reduce the time frame, costs, and efforts in developing a new novel drug. This strategy has secured significant momentum in the previous decade. It overcomes the snags and pitfalls in the traditional means of drug discovery. This core research strategy has now become the sole approach to containing many deadly diseases that have no cure in the present. In astound, for pandemics like COVID-19 that is spreading like a wildfire worldwi Drug repositioning, Drug development, Antibacterial, Antiviral, Anticancer, SARs-Cov-2 https://www.ijper.org/article/56/2s/S200-S215 2026-04-27T10:58:46.34654+00:00 Formulation Development and Optimization of Bioenhanced Sublingual Tablets of Rizatriptan Benzoate to Combat Migraine 2022-05-28 10.5530/ijper.56.2s.91 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-200.pdf Introduction: The drugs belonging to BCS class III, create various challenges for the development of sublingual dosage form due to poor absorption through sublingual mucosa. The sublingual drug delivery is suitable for potent drugs only and prevents the firstpass metabolism of drugs, leading to its direct absorption into the systemic circulation. Objectives: The purpose of the present research was to formulate a fast-dissolving sublingual tablet and enhance the permeability of rizatriptan benzoa Sublingual tablets, Rizatriptan benzoate, Migraine, Wet granulation, polyplasdone XL, Sepitrap 80, Ex vivo permeability https://www.ijper.org/a-32-factorial-design-approach-for-formulation-and-optimization-of-azilsartan-me 2026-04-13T05:54:28.272173+00:00 A 32 Factorial Design Approach for Formulation and Optimization of Azilsartan Medoxomil Nanosuspension for Solubility Enhancement 2022-05-28 10.5530/ijper.56.2s.107 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-365.pdf Background: Azilsartan medoxomil (AZL) is an orally active nonpeptide angiotensin II receptor antagonist with less water solubility and oral bioavailability. Objectives: Increase the solubility and dissolving rate of AZL. Materials and Methods: For formulation we used a probe sonication approach to create nanocrystals. The impacts of independent factors such as % polymer concentration (X1) and sonication duration (X2 min) on dependent variables such as particle size (Y1 nm) and % drug release (D Azilsartan medoxomil (AZL), Nanocrystal, Sonication, Solubility, Drug release https://www.ijper.org/article/56/2s/S245-S252 2026-04-13T05:54:28.272173+00:00 Novel Formulation for Facial Acne using Liposomal Gel Containing Lipid Soluble Naphthoic Acid Derivative 2022-05-28 10.5530/ijper.56.2s.95 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-245.pdf The first line therapies in many acne diagnoses include application of retinoic acid derivatives for improvement in acne severity. Though, it has been observed that, current available formulations are sensitive to skin and requires to be applied after repeated time to prolong the action of the medicament at the local layers. To overcome this major downside, in the present investigation the Adapalene (AD) being entrapped into the lipid layers of the liposomes (LUVs) to provide the sustain release Liposomal gel, Adapalene, Ex-vivo skin retention study, % entrapment, efficiency, in-vitro drug release study https://www.ijper.org/article/56/2s/S326-S338 2026-04-13T05:54:28.272173+00:00 Murraya koenigii Extract Loaded Phytosomes Prepared using Antisolvent Precipitation Technique for Improved Antidiabetic and Hypolidemic Activity 2022-05-28 10.5530/ijper.56.2s.103 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-326.pdf Background: Phytosome is a novel technique introduced by Indena that combines standardised herbal extract and phospholipid in preferably equal ratio to provide better absorption enhancing bioavailability. Purpose: The objective of proposed study is to prepare, optimise and characterize phytosomes of Murraya koenigii (Linn.) Spreng extract to improve its antidiabetic properties. Materials and Methods: Antisolvent precipitation technique was used to prepare phytosomes. Design expert software was u Murraya koenigii, Phytosomes, Antidiabetics, Herbal formulation, Herbal, extract https://www.ijper.org/article/56/2s/S294-S302 2026-04-13T05:54:28.272173+00:00 Phytochemical Characterization of Argemone mexicana Leaf Extracts: An Evidence for its Antiandrogenic and Antioxidant Activities 2022-05-28 10.5530/ijper.56.2s.100 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-294.pdf Introduction: The naturally available herbs are used for medicinal purpose to promote health. The leaves of Argemone mexicana is one such herb used against different ailments. However, studies involving the characterization of different solvent extracts of the leaves and its antioxidant as well as antiandrogenic properties were limited. Aim: The present study aimed to characterize A. mexicana leaf extracts and determine its biological activities. Materials and Methods: The leaves were washed, sh Antioxidant, Polycystic ovary syndrome, Antiandrogenic, Phytochemistry, Polyphenols, Antisteroidogenic https://www.ijper.org/validated-high-performance-liquid-chromatography-method-for-the-quantification-o 2026-04-13T05:54:28.272173+00:00 Validated High Performance Liquid Chromatography Method for the Quantification of Loteprednol Etabonate in Self Micro Emulsifying Drug Delivery Systems 2022-05-28 10.5530/ijper.56.2s.104 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-339.pdf Background: The objective of this work is to develop and validate a reverse-phase HPLC method for determining Loteprednol Etabonate in self micro emulsifying drug delivery systems at nanogram level. Methods: A systematic approach has been implemented for the optimization of chromatographic conditions. The developed reverse-phase HPLC method was validated for linearity, accuracy, precision, limit of detection and quantification, extraction recovery, specificity (matrix effect and forced degradati Loteprednol etabonate, HPLC, stability indicating, analytical method, Self, micro emulsifying systems https://www.ijper.org/formulation-optimization-and-evaluation-of-ticagrelor-loaded-self-microemulsifyi 2026-04-13T05:54:28.272173+00:00 Formulation, Optimization and Evaluation of Ticagrelor Loaded Self Microemulsifying Chewable Tablets 2022-05-28 10.5530/ijper.56.2s.93 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2s-225.pdf Ticagrelor is a new generation Adenosine diphosphate receptor inhibitor drug which is highly lipohilic having poor aqueous solubility used in the treatment of Acute Coronary Syndrome and prevention of Thrombotic events like Stroke and Heart Attack. An approach has been made to develop Chewable tablets of drug loaded on Self-microemulsifying drug delivery systems (SMEDDS), screen suitable adsorbent for solidification of formulated SMEDDS and to study the effect of superdisintegrants in chewable t Ticagrelor, SMEDDS, Adsorbents, Chewable tablets, Acute coronary, syndrome https://www.ijper.org/determination-of-nitazoxanide-in-biological-matrices-by-lc-msms-technique-method 2026-04-13T05:54:29.78521+00:00 Determination of Nitazoxanide in Biological Matrices by LC-MS/MS Technique: Method Development and Validation 2022-03-18 10.5530/ijper.56.2.76 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-539.pdf Background: Determination of pharmaceuticals in the biological matrices is essential for toxicologic and pharmacokinetic applications. The main objective of the current work was to develop a bioanalytical method for quantifying nitazoxanide in biological samples by LC-MS/MS. Materials and Methods: Chromatographic elution of nitazoxanide and linagliptin were achieved on C18-hypersil (5 μ, 50x4.6mm) stationary phase with mobile phase consisting of acetonitrile and 0.1% HCOOH (75:15, v/v) processed Nitazoxanide, Antiviral, LC-MS/MS, Validation, Accuracy https://www.ijper.org/article/56/2/329-346 2026-04-13T05:54:29.78521+00:00 Perspectives of Presynaptic Autoreceptors and Presynaptic Heteroreceptors in the Mechanism of Neurotransmission 2022-03-18 10.5530/ijper.56.2.53 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-329.pdf The presynaptic autoreceptors and / or presynaptic heteroreceptors of the principal neurotransmitters involved in the release mechanism of neurotransmission have been identified employing various experimental models, based on receptor types / receptor subtypes and it’s stimulatory or inhibitory functions. The pharmacological, neurophysiological, neurobiochemical in vivo or in vitro insect, animal or human prototype experimental models were selected from the exhaustive search of literature publis Presynaptic, Autoreceptors, Heteroreceptors, Neurotransmitter, Tissue models, Neuronal functions https://www.ijper.org/development-of-fast-precise-and-selective-rp-hplc-methods-for-identification-of 2026-04-13T05:54:29.78521+00:00 Development of Fast, Precise and Selective RP-HPLC Methods for Identification of Possible Degradation Products of Ivermectin in Isolated Rat Hepatocytes and in Different pH Media 2022-03-18 10.5530/ijper.56.2.77 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-546.pdf Aim: A new stability indicating RP-HPLC based methods were developed to identify the possible degradation products of Ivermectin in isolated rat hepatocytes and in different pH media using a C18 RP column. Complete validation, including linearity, accuracy, recovery, precision, robustness, stability, and peak purity, was performed. Materials and Methods: HPLC system of UltiMateDionex 3000 DAD with LiChrosorb C18 Column were used in this study. During the investigation, for the removal of interfe Ivermectin, in vitro, Metabolism, Chemical stability, RP-HPLC https://www.ijper.org/article/56/2/438-447 2026-04-27T10:49:06.014208+00:00 Comprehensive Analytical Characterization of the Proposed Biosimilar Trastuzumab 2022-03-18 10.5530/ijper.56.2.64 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-438.pdf Background: Biosimilars to monoclonal antibodies were developed to increase the accessibility of this drug and reduce the costs of this therapy without compromising on its quality, safety, and efficacy. The objective of this research is to describe the orthogonal analytical methods used for the physicochemical and biological characterization of the biosimilar proposed to trastuzumab, which is the basis of the biosimilar development program. Methods: The orthogonal analytical methods for characte Therapeutic Monoclonal Antibody, Biosimilar, Critical Quality Attributes, Charge Variants, Aggregates, Fragments, Post-translational modifications, N-Linked, Glycan and Antibody dependent cellular cytotoxicity https://www.ijper.org/evaluation-of-the-effect-of-methotrexate-on-psoriasis-based-on-specialized-pharm 2026-04-13T05:54:29.78521+00:00 Evaluation of the Effect of Methotrexate on Psoriasis Based on Specialized Pharmaceutical Education 2022-03-18 10.5530/ijper.56.2.56 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-364.pdf Background: Methotrexate (MTX) is still the gold standard therapy for moderate to severe psoriasis. There is a marked interpersonal variation in the therapeutic response and toxicity profile of MTX which brings difficulty for clinical application. Objectives: To establish the specialized pharmaceutical education (SPE) mode for psoriasis administrated with MTX and assess the therapeutic effect between cases received SPE and usual health care in the real-world. Materials and Methods: In this retro Methotrexate, Psoriasis vulgaris, Pharmaceutical education, Effect evaluation, Real world implementation https://www.ijper.org/IndJPhaEdRes-56-2-311 2026-04-13T05:54:29.78521+00:00 Aromatase Inhibitors: Development and Current Perspectives 2022-03-18 10.5530/ijper.56.2.51 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-311.pdf Aim: Breast cancer is one of the most common cancers among women, consistently elevated estrogen level in the blood associated with persistently in breast cancer found in many studies. The mechanisms of carcinogenesis whereby cancer is associated involved in the conversion of androgen to estrogen in the presence of enzyme aromatase. Materials and Methods: Aromatase is a (CYP19), a cytochrome P450, which is the enzyme that synthesizes estrogen. Aromatase which is expressed in higher concentration Non-Steroidal aromatase inhibitor, Aromatase, Cancer, Aromatase Inhibitors https://www.ijper.org/investigating-the-role-and-mechanism-of-octreotide-in-long-standing-diabetes-ind 2026-04-13T05:54:29.78521+00:00 Investigating the Role and Mechanism of Octreotide in Long Standing Diabetes-induced Cognitive Impairment in Rats 2022-03-18 10.5530/ijper.56.2.65 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-448.pdf Background: Octreotide is a somatostatin analogue and it produces beneficial effects in diabetic-neuropathy. Studies have also shown its beneficial role in Alzheimer disease. However, the role of octreotide in diabetes-induced cognitive impairment is not explored yet. Aim: The present study was designed to explore the role and mechanism of octreotide in long standing diabetes-induced cognitive impairment in an experimental model. Materials and Methods: Streptozotocin (60 mg/kg)-injected rats wer Oxidative stress, Diabetes, Memory, Octreotide, Neuroinflammation, Learning https://www.ijper.org/anti-inflammatory-and-anti-hyperuricemic-effect-of-ficus-benghalensis-bark-extra 2026-04-27T10:52:15.22555+00:00 Anti-inflammatory and Anti-hyperuricemic Effect of Ficus benghalensis Bark Extract in Raw 246.7 Cell Line 2022-03-18 10.5530/ijper.56.2.74 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-520.pdf Background: Hyperuricemia and inflammation are associated with the etiology and pathogenesis of several metabolic diseases. Controlling the elevated levels of uric acid and inflammation can be a potential therapeutic option for several metabolic diseases. Aim: The current study examined the anti-inflammatory and anti-hyperuricemic properties of Ficus benghalensis bark extract in vitro using murine macrophage RAW 246.7 cells. Materials and Methods: Hydroalcoholic extracts of Ficus benghalensis ba Anti-hyperuricemic, RAW 246.7 cells, Ficus benghalensis bark extract, Antiinflammatory, TNF-α, IL- 10, Lipopolysaccharide https://www.ijper.org/water-in-silicone-emulsion-the-approach-to-an-ideal-bb-cream 2026-04-13T05:54:29.78521+00:00 Water-in-Silicone Emulsion – The Approach to an Ideal BB Cream 2022-03-18 10.5530/ijper.56.2.57 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-372.pdf Silicone is a widely-used cosmetic ingredient, whose advantages are perceived as detackification, soft and non-greasy feeling, and excellent spreading quality. Therefore, in this work, we aim to formulate BB cream based on W/Si emulsion to make the most out of these benefits. Two different emulsifiers namely PEG/PPG-18/18 Dimethicone – a common silicone emulsifier and Lauryl PEG-10 Tris(Trimethylsiloxy)silylethyl Dimethicone – a new silicone emulsifier, were tested. Upon completion, the properti Silicone, BB Cream, W/Si emulsion, Dimethiconol, Lauryl PEG-10, Tris(Trimethylsiloxy)silylethyl Dimethicone https://www.ijper.org/evaluation-of-anticancer-potential-of-mimosa-diplotricha-ethanolic-leaf-extract 2026-04-13T05:54:29.78521+00:00 Evaluation of Anticancer Potential of Mimosa diplotricha Ethanolic Leaf Extract on N-Methyl-NNitroso Urea Induced Colorectal Carcinogenesis in Wistar Albino Rats 2022-03-18 10.5530/ijper.56.2.69 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-479.pdf Background: Colorectal Cancer, (CRC) ranks third among global cancer incidence statistics and occupies fourth position as far as cancer related death is concerned and the aim of the study is to evaluate the therapeutic potential of Mimosa diplotricha ethanolic leaf extract in chemically induced colorectal carcinogenesis in Wistar albino rats. Materials and Methods: CRC was induced by intrarectal instillation of N-Methyl-N-Nitrosourea (MNU), 2mg per rat in 0.5ml of distilled water three times a w CRC, Wistar rats, MNU, Mimosa diplotricha, Serum markers, Bcl-2 https://www.ijper.org/article/56/2/503-510 2026-04-13T05:54:29.78521+00:00 Modulation of Oxidative Stress Induced Cerebral Ischemia in Wistar Rats by Hydroalcoholic Extract of Talinum triangulare 2022-03-18 10.5530/ijper.56.2.72 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-503.pdf Background: Neuroprotection is one of considerable interest in search of novel therapies to improve ischemic brain damage in the present scenario. The objective of the present investigation is to study the actions of Talinum triangulare in cerebral ischemia/reperfusion induced oxidative stress in Wistar rats and in-vitro antioxidant actions. Methods: Four different groups of adult Wistar rats are selected for study where group III and group IV are treated for 15 days with TTE (200mg/kg, 400mg/kg Talinum triangulare, Cerebral ischemia reperfusion, Oxidative stress, Cerebroprotection, Antioxidant acivity https://www.ijper.org/in-vivo-wound-healing-potential-of-raloxifene-nanoemulsion-gel-for-the-managemen 2026-04-13T05:54:29.78521+00:00 In vivo Wound Healing Potential of Raloxifene Nanoemulsion Gel for the Management of Postmenopausal Cutaneous Wounds 2022-03-18 10.5530/ijper.56.2.82 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-589.pdf Background: Depletion in estrogen level(s) especially in postmenopausal women is reported to have delayed wound healing effects; hence we have evaluated the wound healing potential of raloxifene in rat model. Objectives: Investigating the wound healing effects of raloxifene nanoemulsion for the management of postmenopausal cutaneous wounds. Materials and Methods: The optimized nanoemulsion gel contains 0.072% raloxifene hydrochloride. Female Wistar rats were used to investigate its wound healing Raloxifene, Nanoemulsion gel, Ovariectomized, Postmenopausal, Breaking, strength, Wound contraction, Hydroxyproline, Histopathology https://www.ijper.org/synthesis-of-transition-metal-complexes-of-isoniazid-derivatives-and-urease-inhi 2026-04-13T05:54:29.78521+00:00 Synthesis of Transition Metal Complexes of Isoniazid Derivatives and Urease Inhibition Activity Detection 2022-03-18 10.5530/ijper.56.2.80 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-573.pdf It have been reported that the transition metal complex of Schiff base ligands have the ability to inhibit urease. Herein, in this manuscript, two novel transition metal complexes [Cd2(L)2·(H2O)] (1), [Pb(L)·, [Pbe2) were synthesized based on chelating hydrazone ligand N‘-(pyridin-2-ylmethylene)isonicotinohydrazide (L). These compounds were tested by single crystal X-ray diffraction and determined by structure and tested for urease resistance in vitro. The complex 2 exhibited better the activiti Cadmium(II) complexes, Plumbum(II) complexes, Crystal structure, Schiff, base, Urease inhibitor https://www.ijper.org/temporal-unpredictability-and-probabilistic-uncertainty-induced-anxiety-in-the-t 2026-04-13T05:54:29.78521+00:00 Temporal Unpredictability and Probabilistic Uncertainty Induced Anxiety in the Times of COVID-19 Pandemic 2022-03-18 10.5530/ijper.56.2.52 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-321.pdf Human beings prefer a predictable and certain environment over an unpredictable and uncertain environment. No one predicted the coronavirus pandemic and it is not certain when the pandemic will come to an end. Pandemics not only affect the physical health but also the mental health of the public. An increase in anxiety and suicide rates has been reported during the previous pandemics and the same trend is also being observed in this current pandemic as well. Pandemics inevitably result in unpred Coronavirus, Pandemic, Unpredictability, Uncertainty, Stress, Anxiety, Suicide https://www.ijper.org/pazopanib-colon-targeted-liposomal-drug-delivery-for-colorectal-cancer-high-pres 2026-04-13T05:54:29.78521+00:00 Pazopanib Colon Targeted Liposomal Drug Delivery for Colorectal Cancer: High-pressure Homogenization Process Optimization and in-vivo Evaluation 2022-03-18 10.5530/ijper.56.2.58 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-387.pdf Background: Pazopanib is second-generation tyrosinekinase inhibitor used in Colorectal cancer (CRC) which is effective orally. Targeted liposomal drug delivery will reduce the unwanted side effects of the drug. The application of High-pressure homogenizers for the preparation of systems like liposomes and lipid dispersions is rising because of its ability of vesicle disruption. Aim: Major objective of present research work was to optimize high pressure homogenization process for formulation of c Liposome, Pazopanib, High-pressure homogenizer, Colon targeted, Colorectal https://www.ijper.org/bioguided-isolation-of-alternariol-derivatives-from-ficus-derived-endophyte-alte 2026-04-13T05:54:29.78521+00:00 Bioguided Isolation of Alternariol Derivatives from Ficus-derived Endophyte Alternaria alternata 2022-03-18 10.5530/ijper.56.2.71 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-497.pdf Background: Endophytes are a rich source of bioactive natural products and suggested to contribute to the biological or defense activities of their host plants. Following our research on the discovery of bioactive metabolites from endophytes, Alternaria alternata was isolated from the leaves of Ficus carica L. fam Moraceae. Materials and Methods: Large scale cultivation of the endophytic strain was carried out and the obtained extract was subjected to preliminary screening of antifungal and cyto Endophyte, Alternariol, Alternaria alternata, Anticancer, Ficus carica https://www.ijper.org/investigation-on-in-vitro-dissolution-and-tableting-properties-enhancement-of-et 2026-04-13T05:54:29.78521+00:00 Investigation on in-vitro Dissolution and Tableting Properties Enhancement of Etodolac using Stearoyl polyoxyl-32-glycerides as Novel Solid Melt Carrier 2022-03-18 10.5530/ijper.56.2.62 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-420.pdf Objectives: The objective of present study was to improve dissolution rate with tableting properties of BCS class II drug Etodolac, by melt granulation and sublimation techniques. Materials and Methods: The granules of etodolac were formulated using Gelucire 50/13. The surface adsorbent Aerosil 200 was utilized. Both melt granulation and surface adsorption method in conjunction with sublimating agent were used to formulate tablets of Etodolac. Etodolac: Gelucire 50/13: Aerosil200 was used in dif Etodolac, Gelucire50/13, Melt granulation, Sublimating agent, Surface, adsorption, Dissolution improvement https://www.ijper.org/antioxidant-and-cytotoxic-activity-of-steroidal-alkaloids-isolated-from-sarcococ 2026-04-13T05:54:29.78521+00:00 Antioxidant and Cytotoxic activity of Steroidal Alkaloids Isolated from Sarcococca saligna against DPPH and HeLa Cell Lines 2022-03-18 10.5530/ijper.56.2.70 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-489.pdf Background and Objectives: Cancer is believed to be one of the main challenges to health care profession and compounds isolated from natural products play significant role in treatment of cancer. Sarcococca saligna (Buxaceae) contains variety of steroidal alkaloids having numerous pharmacological and biological potentials. Hence, current research work was designed to isolate steroidal alkaloids from Sarcococca saligna and to evaluate it for antioxidant and cytotoxic activity. Materials and Metho Sarcococca saligna, Alkaloid-C, Dictyophlebine, Sarcovagine-D, Holaphylline, Doxorubicin, IC50 https://www.ijper.org/design-of-experiment-mediated-development-of-stability-indicating-high-performan 2026-04-13T05:54:29.78521+00:00 Design of Experiment Mediated Development of Stability Indicating High Performance Thin Layer Chromatography Method Invoking Failure Mode Effect Analysis Based Risk Assessment in Estimation of Edoxaban Tosylate Monohydrate 2022-03-18 10.5530/ijper.56.2.78 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-553.pdf Aim: Development of stability indicating high performance thin layer chromatographic method for quantification of edoxaban tosylate monohydrate in its pharmaceutical dosage form using quality by design approach. Methods: Degradation was performed in acidic, alkaline, neutral, oxidative and photolytic conditions. Analytical target profile was identified, based on which failure modes were identified by brainstorming session and preliminary trials. Each failure mode was assigned a risk priority num Edoxaban tosylate monohydrate, Stability indicating High Performance Thin, Layer Chromatography, Failure mode effect analysis, 32 full factorial design, Design of, experiment https://www.ijper.org/formulation-of-silk-fibroin-based-single-polymeric-floating-microspheres-for-sus 2026-04-27T10:46:23.338169+00:00 Formulation of Silk Fibroin-based Single Polymeric Floating Microspheres for Sustained Release of Lafutidine 2022-03-18 10.5530/ijper.56.2.59 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-396.pdf Purpose: The present study was aimed at the formulation of lafutidine-loaded silk fibroinbased floating microspheres (LAFU-SF-Microspheres) for the site-specific sustained release of the drug. Materials and Methods: Briefly, the single polymeric system comprising SF was selected to prepare LAFU-SF-Microspheres by employing the emulsion solvent evaporation method. Subsequently, the obtained LAFU-SF-Microspheres were assessed for particle size, zeta potential, percent entrapment efficiency (%EE), Lafutidine, Silk fibroin, Microsphere, Floating drug delivery, Sustained release https://www.ijper.org/protective-effect-of-the-aqueous-extract-of-cyamopsis-tetragonoloba-seed-against 2026-04-13T05:54:29.78521+00:00 Protective Effect of the Aqueous Extract of Cyamopsis tetragonoloba Seed against the Paracetamol-induced Toxicity in Female Wistar Albino Rats 2022-03-18 10.5530/ijper.56.2.81 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-580.pdf Background: Paracetamol is also known as acetaminophen which is the most widely and commonly used painkiller drug among the overall human population. On excess usage and high dosage, paracetamol can cause liver injury, gastrointestinal damage and kidney damage. Cyamopsis tetragonoloba is the most commonly available plant in India which has weight loss properties as well as used to treat cancer and diabetes. Aim: This study is to estimate the potential effect of C. tetragonoloba against paracetam Cyamopsis tetragonoloba, Pharmaceutical drug-induced toxicity, Plant, extract, Paracetamol, Wistar albino rats https://www.ijper.org/antimicrobial-antioxidant-and-cytotoxic-activities-of-different-fractions-obtain 2026-04-13T05:54:29.78521+00:00 Antimicrobial, Antioxidant and Cytotoxic Activities of Different Fractions Obtained from Endophytic Fusarium solani F01 Isolated in Catharanthus roseus Collected in Vietnam 2022-03-18 10.5530/ijper.56.2.67 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-461.pdf Aim: Finding out the biological sources is essential for pharmaceutical field. Materials and Methods: Endophytic fungus was isolated from Catharanthus roseus originated in Vietnam and then identified by comparing, phylogeny analyzing its 18S sRNA sequence using Blast search and GenomeNet. The supernatant and sonicated mycelia were fractionated with methanol, ethyl acetate, hexane. All the fractions were used to test antimicrobial, antioxidant, cytotoxicity activities. Antimicrobial activities on Catharanthus roseus, Identification, Molecular analysis, Biological activities, Extraction, Purification https://www.ijper.org/rapid-simultaneous-quantitative-analysis-of-hypoglycemic-agents-by-rp-hplc-devel 2026-04-13T05:54:29.78521+00:00 Rapid Simultaneous Quantitative Analysis of Hypoglycemic agents by RP HPLC: Development, Validation and Application to Medicine 2022-03-18 10.5530/ijper.56.2.79 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-564.pdf Background: For the treatment of diabetes mellitus type 2, a new formulation containing vildagliptin and remogliflozin was developed. A simple and rapid RP-HPLC method employing linagliptin as an internal standard was developed for quality control of this medicine. Methodology: Formulation analytes, including IS, were separated on a Zorbax C18 column with isocratic elution of acetonitrile and phosphate buffer (pH 5) 55:45 v/v at a flow rate of 1.2 mL/min. The experiment was carried out at room t Vildagliptin, remogliflozin, HPLC method, Validation, Formulation, Robustness, Multivariate https://www.ijper.org/synthesis-characterization-and-comparison-of-novel-poly-sebacic-anhydride-biopol 2026-04-13T05:54:29.78521+00:00 Synthesis, Characterization and Comparison of Novel Poly (sebacic anhydride) Biopolymeric Implants and Microspheres for the Controlled Release of an Anticancer Drug 2022-03-18 10.5530/ijper.56.2.63 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-429.pdf Aim: The purpose of this study was to investigate the comparative drug release kinetics of implants and microspheres of an anticancer drug loaded onto a bio-degradable polymer. Methods: Poly (sebacic anhydride) was synthesized using a melt-polycondensation reaction, and its physicochemical properties were determined using gel permeation chromatography, nuclear magnetic resonance, differential scanning calorimetry, and Fourier transform infrared techniques. The polymer was used to encapsulate dru Implants, Microspheres, Drug delivery, Sustained release, Biodegradation https://www.ijper.org/article/56/2/470-478 2026-04-13T05:54:29.78521+00:00 Antidiabetic Potential of Ficus glomerata Roots with a Special Emphasis on Estimation of Bioactive Compounds by a Novel Validated HPTLC Technique 2022-03-18 10.5530/ijper.56.2.68 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-470.pdf Background: The data presented in this article for Ficus glomerata Linn. belonging to family Moraceace which is commonly found all over India. This study aimed towards the development and validation of high-performance thin-layer chromatography (HPTLC) method for simultaneous estimation of lupeol and quercetin from Ficus glomerata and correlate with its antidiabetic potential. Methods: The various fractions of ethanolic extract of Ficus glomerata root were prepared. The HPTLC analysis of quercet Ficus glomerata, HPTLC, Lupeol, Quercetin, Alloxan, Antidiabetic activity https://www.ijper.org/article/56/2/405-413 2026-04-13T05:54:29.78521+00:00 Application of Central Composite Design for Development of Celecoxib Loaded Lipospheres: Formulation and in-vitro Characterization 2022-03-18 10.5530/ijper.56.2.60 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-405.pdf Background: This study was initiated to develop celecoxib lipospheres to provide controlled release. It demonstrates the use of central composite design for optimization of liposphere formulation with less number of experiments. The development of formulation is primarily based on poor water solubility, low bioavailability and side effects associated with prolonged administration of celecoxib. Methods: Lipospheres were developed by melt dispersion technique and the effect of amount of ethyl olea Celecoxib, Phospholipon 80H, Lipospheres, Central composite design, Melt, dispersion https://www.ijper.org/article/56/2/356-363 2026-04-13T05:54:29.78521+00:00 Is it Time to Introduce the “Precision Tutorial System” for Undergraduate? 2022-03-18 10.5530/ijper.56.2.55 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-356.pdf Objectives: The aim of this study was to investigate the current situation with the undergraduate tutorial system in China from the students’ perspective and to further improve that system for greater developmental benefits. Materials and Methods: We designed a 21-item questionnaire to analyze the current situation with the undergraduate tutorial system. It was administered to freshman, sophomore and junior students taking a pharmacy undergraduate degree. In all, 415 pharmacy students completed Precision tutorial system, Undergraduate, Questionnaire, Pharmacy students, Individual https://www.ijper.org/chemical-constituents-of-phyllanthus-acidus-l-skeels 2026-04-13T05:54:29.78521+00:00 Chemical Constituents of Phyllanthus acidus (L.) Skeels 2022-03-18 10.5530/ijper.56.2.66 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-455.pdf Background: This study describes the isolation of chemical constituents from the leaves and bark of Phyllanthus acidus, a medicinal plant widely used for the treatment of several ailments. Materials and Methods: The crude extract of P. acidus was chromatographed on a gravity column dry packed with silica gel and was fractionated by increasing proportions of acetone in CH2Cl2. The purified isolates were subjected to NMR for structure elucidation. Their structures were identified mainly by using 1 Phyllanthus acidus, Karamay, Phyllanthol, Lupeol, Amyrin, Sitosterol, Stigmasterol https://www.ijper.org/simultaneous-quantification-of-syringic-acid-and-kaempferol-in-methanolic-extrac 2026-04-27T10:52:34.982939+00:00 Simultaneous Quantification of Syringic Acid and Kaempferol in Methanolic Extract of Cleome viscosa Linn. by Using Validated HPTLC-Densitometric Method 2022-03-18 10.5530/ijper.56.2.75 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-529.pdf Cleome viscosa Linn. (Capparaceae) commonly known as “Hurhur”, is a traditional medicinal plant used in the treatment of various ailments such as fever, inflammation, liver disorder, ulcer stomachache etc. In the present study, pharmacognostical and pharmacological evaluation of Cleome viscosa were done, on the basis of traditional claim. A validated HPTLC method was also developed for the simultaneous quantification of bioactive compounds i.e. syringic acid and kaempferol in C. viscosa. The chr Cleome viscosa, HPTLC, Syringic acid, Kaempferol, in-vitro https://www.ijper.org/antitumor-and-cytotoxic-protein-component-from-aporrectodea-longa-purification-a 2026-04-13T05:54:29.78521+00:00 Antitumor and Cytotoxic Protein Component from Aporrectodea longa: Purification, and Characterization Studies 2022-03-18 10.5530/ijper.56.2.73 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-511.pdf Background: Cancer, a metabolic disorder with multifactorial input, is the most complex human disease to study and find a cure. Over several decades, massive research effort leads to a better understanding molecular biology of cancer and its progression. Plants and animals both were explored for novel anti-tumor agents, and enzyme-based drugs have shown significant results. These animals evolved with an enzyme with promiscuous nature capable of catalyzing multiple biochemical reactions. Enzymes Antineoplastic agents, Cytotoxic activity, MTT assay, Chromatography, Cell, lines, Protein/enzyme https://www.ijper.org/article/56/2/347-355 2026-04-13T05:54:29.78521+00:00 A Brief Review on Solubility Enhancement Technique: Hydrotropy 2022-03-18 10.5530/ijper.56.2.54 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-347.pdf In this review we have elaborated about number of hypothesis postulated to understand the mechanism of hydrotropic agents, although majority of the postulated hypothesis haven’t justified the solubility enhancement mechanism. Further to it the articles focuses upon the parameters affecting enhancement of solubilizing ability. Hydrotropes are extensively used in drug solubilization, extraction agents for various phytoconstituents, separation agent used for pharmaceutical analysis, as well as for Mixed Hydrotropy, Solubilizing agent, Mechanisms of hydrotropes, Application, of Hydrotropes, Solubility, Bioavailability enhancement https://www.ijper.org/formulation-and-evaluation-of-bendamustine-loaded-polymeric-nanoparticle 2026-04-13T05:54:29.78521+00:00 Formulation and Evaluation of Bendamustine Loaded Polymeric Nanoparticle 2022-03-18 10.5530/ijper.56.2.61 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-2-414.pdf Background: Bendamustine-loaded albumin nanoparticles were prepared using different concentrations of Bovine Serum Albumin (BSA) with the goal of delivering the medication to particular cancer cells. Materials and Procedures: The nanoparticles were prepared using simple coacervation technique with increasing concentrations of BSA. The nanoparticles were characterized for process yield, particle size, surface morphology, drug loading capacity (%), particle size distribution (Polydispersity index) Nanoparticles, Bendamustine, Cancer, Bovine serum albumin, Bendamustine, albumin, Release kinetics, Surface morphology https://www.ijper.org/in-vitro-evaluation-of-anti-microbial-and-cytotoxic-activity-of-artemisia-judaic 2026-04-13T05:54:30.538377+00:00 In-vitro Evaluation of Anti-microbial and Cytotoxic Activity of Artemisia judaica Leaves and Stem Extracts via Induction of Caspase Dependent Apoptosis 2022-01-12 10.5530/ijper.56.1s.42 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1s-52.pdf Medicinal plants and herbs are commonly used in the world to treat various human disorders. Artemisia judaica is one of these herbal species that is commonly used in medicine due to its contents of many bioactive compounds such as; flavonoids, lactones, essential oil and sesqui-terpenoids. It was used in many traditional medicines as an anthelmintic, antispasmodic, anti-rheumatic, and antibacterial agent. In recent years, anti-bacterial and anti-cancer activity of medicinal herbs are highly inve Artemisia judaica, Antimicrobial, Anticancer, Apoptosis, Mechanism https://www.ijper.org/article/56/1s/S58-S66 2026-04-13T05:54:30.538377+00:00 Identification and Characterization of in vitro Metabolites of Belinostat by Rat Liver Microsomes using Ultra Performance Liquid Chromatography Coupled with Tandem Mass Spectrometry 2022-01-12 10.5530/ijper.56.1s.43 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1s-58.pdf Objectives: The objective of the present study is to study the in-vitro metabolites of FDA approved anticancer drug, belinostat which is a histone deacetylase inhibitor. Methods: The metabolites were formed by incubating the drug, belinostat with rat liver microsomes, at 37°C for 24 hr. The newly formed metabolites were identified and characterized with the help of ultra-high performance liquid chromatography which is interlinked with tandem quadrupole time-of-flight mass spectrometry. Results: Belinostat; Rat Liver Microsomes; Characterization; in-vitro Metabolites;, Enzyme Kinetics; LC-MS/MS https://www.ijper.org/public-perceptions-concerning-community-pharmacy-services-in-jouf-region-kingdom 2026-04-13T05:54:30.538377+00:00 Public Perceptions Concerning Community Pharmacy Services in Jouf Region, Kingdom of Saudi Arabia in Reference to COVID-19 Pandemic 2022-01-12 10.5530/ijper.56.1s.50 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1s-115.pdf Aim/Background: The present study was aimed at investigating the public perceptions about extended services by community pharmacists in Jouf region of Saudi Arabia during COVID-19 pandemic. Design: Institutional based cross sectional prospective survey. The sample size was calculated by an online sample size calculator named Raosoft®️. The calculated sample for this study was 945 with a 5% error margin, confidence interval of 95%, the population size fixed at 200000. Study instrument: A 34-item Community pharmacists, Jouf city, Perceptions, COVID-19, Public, Services https://www.ijper.org/implementation-of-project-based-learning-innovation-to-develop-students-critical 2026-04-13T05:54:30.538377+00:00 Implementation of Project-based Learning Innovation to Develop Students’ Critical Thinking Skills as a Strategy to Achieve Analytical Chemistry Competencies 2022-01-12 10.5530/ijper.56.1s.41 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1s-41.pdf Background: The ability to think critically is one of the life skill targets that pharmacists and scientists want to achieve in learning, therefore it is necessary to do project-based learning innovations to guide students to learn actively and independently in developing critical thinking skills. Objectives: This study aims to implement project-based learning to facilitate active and independent learning through project implementation to build students’ critical thinking skills and at the same Project-based learning, Learning innovation, Critical thinking skills, Students, competence, Learning outcomes https://www.ijper.org/perceived-stress-and-its-triggers-among-pharmacy-university-students-in-comparis 2026-04-13T05:54:30.538377+00:00 Perceived Stress and its Triggers among Pharmacy University Students in Comparison to Student of Other Faculties: A Cross Sectional Study 2022-01-12 10.5530/ijper.56.1s.48 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1s-98.pdf Background and Objectives: The role of stress in causing mental and physical damage is well known. The deleterious effect of stress is more dominant in young university students as they encounter repeated examinations amidst high expectation from the society. This study is an attempt to uncover the impact of stress on the university students and compare the level of stress among students of different health science programs. Materials and Methods: This cross-sectional comparative study was carri Stress, University students, Stress relievers, Medicine, Pharmacy, Applied, Science, Stress management https://www.ijper.org/article/56/1s/S75-S80 2026-04-13T05:54:30.538377+00:00 Ocular Delivery of Atenolol Loaded Microsponge in-situ Gel: Development, Characterization and in-vitro Evaluation 2022-01-12 10.5530/ijper.56.1s.45 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1s-75.pdf Aim/Background: The purpose of the study was to fabricate and evaluate atenolol loaded micro-sponge in-situ gel. Materials and Methods: Oil in Oil Emulsion Solvent Diffusion Technique was used for formulation of microsponges by using different levels of polymers such as Eudragit RS-100 and Ethyl Cellulose. The prepared micro-sponges were evaluated for optical microscopy, percentage yield, drug content, entrapment efficiency and surface morphology studies. The micro sponges were loaded into in-si Microsponge, Atenolol, Ethyl Cellulose, Eudragit RS-100, in situ gel https://www.ijper.org/an-expeditious-approach-to-the-synthesis-of-novel-quinolino-and-diazacino-conden 2026-04-13T05:54:30.538377+00:00 An Expeditious Approach to the Synthesis of Novel Quinolino and Diazacino Condensed Analogues of Azepino [3, 2-b] Carbazole-2-one of Medicinal Interest 2022-01-12 10.5530/ijper.56.1s.47 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1s-89.pdf Background: Quinolino and diazacino are important heterocyclics moiety, which have been reported to possess various activities such as antiallergenic, antifungal, hypocholesterolemic, antibacterial and antiviral activities. The activities of these compounds were related to inhibition of bacterial dehydrogenase enzyme which is one of the important targets studied for designing of antimicrobial drugs. Further, molecular docking approached is used in the present study for confirming potent molecule Antimicrobial, Azepino [3, 2-b] carbazole-2-one, Pfitzinger reaction, Beckmann, rearrangement, Organocatalyst https://www.ijper.org/article/56/1s/S81-S88 2026-04-13T05:54:30.538377+00:00 Protective Effects of Silymarin and/or Omega-3 Fatty Acids against Paracetamol-initiated Liver Toxicity in Rats 2022-01-12 10.5530/ijper.56.1s.46 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1s-81.pdf Background and Aim: The proposed experiment was planned to evaluate the potential protective function of aqueous extract of Silymarin (SL) concentrate and/or Omega-3 fatty acids (O3FAs) against PCM-initiated liver toxicity in rats. Materials and Methods: Thirty Wistar-albino rats (either of sex) were distributed among five equivalent groups as follows: Normal control group, PCM control group, PCM + SL group (25 mg/kg, p.o.), PCM + O3FAs group (300 mg/kg, p.o.), PCM + SL + O3FAs group. All the tr Silymarin, Omega-3 fatty acids, TNF-α, IL-6, VEGF, CRP https://www.ijper.org/development-and-characterization-of-cephradine-proniosomes-for-oral-controlled-d 2026-04-13T05:54:30.538377+00:00 Development and Characterization of Cephradine Proniosomes for Oral Controlled Drug Delivery 2022-01-12 10.5530/ijper.56.1s.44 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1s-67.pdf The role of Proniosomes in oral controlled drug delivery system is well accepted. Presently, an attempt was made to develop cephradine (CP) Proniosomes to prolong its duration of action with better efficacy. Overall, eighteen formulation trials were developed using variable quantities of sorbitol (F0S-F8S) and maltodextrin (F0M-F8M) carriers along with span60 and cholesterol. Trials were evaluated for powder flowability, drug entrapment efficiency and in vitro drug release. Based on the mentione Proniosomes, Cephradine, Nano-carriers, Niosomes, Bactericidal activity, Controlled drug delivery https://www.ijper.org/chemical-composition-antioxidant-and-antimicrobial-properties-of-vangueria-madag 2026-04-13T05:54:30.538377+00:00 Chemical Composition, Antioxidant and Antimicrobial Properties of Vangueria madagascariensis J.F.Gmelin (Kirkir) Fruit 2022-01-12 10.5530/ijper.56.1s.40 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1s-32.pdf Background: Vangueria madagascariensis fruits (Kirkir) produces compounds own various nutritional and medicinal properties. Objectives: The study purpose was to investigate the chemical composition and antioxidant properties of kirkir fruits (Vangueria madagascariensis). Materials and Methods: Proximate chemical composition, minerals and antioxidant properties of kirkir fruits were consucted via determination of total flavonoids, Ferric reducing antioxidant power (FRAP) and DPPH free radicals sc Vangueria madagascariensis, Minerals, Polyphenols, Ascorbic acid, Radical, scavenging effect, Methanolic extract https://www.ijper.org/micellar-enhanced-spectrofluorimetric-quantification-of-gemifloxacin-mesylate-in 2026-04-13T05:54:30.538377+00:00 Micellar Enhanced Spectrofluorimetric Quantification of Gemifloxacin Mesylate in Pharmaceuticals and Bio-fluids 2022-01-12 10.5530/ijper.56.1s.37 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1s-1.pdf Introduction: Gemifloxacin mesylate (GFX) is one of the most potential anti-infective agents with broad spectrum and influential activity. Objectives: The current study described a fast and precise spectrofluorometric probe for GFX quantification in authentic drug, commercial tablets and bio-samples. Materials and Methods: The suggested technique was conducted by complexing GFX with Al ions in the presence of alkaline buffer of pH 8. Results: The FI was enhanced by adding sodium dodecyl sulfate Complexation, Gemifloxacin mesylate, Spectrofluorimetry, Pharmaceutical, formulations, Bio-samples https://www.ijper.org/development-and-in-vitro-characterization-of-gastroretentive-formulations-as-cal 2026-04-13T05:54:30.538377+00:00 Development and in vitro Characterization of Gastroretentive Formulations as Calcium Pectinate Hydrogel Pellets of Pregabalin by Ionotropic Gelation Method 2022-01-12 10.5530/ijper.56.1s.38 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1s-9.pdf Introduction: Pregabalin (PG) is primarily prescribed for epilepsy, painful diabetic neuropathy, post-herpetic neuralgia, and fibromyalgia. Also, it is used in clinical practice to treat general anxiety disorder due to its anxiolytic properties. Pectin is a watersoluble ionic polysaccharide. As a result of the interaction of pectin with calcium ions, a hydrophilically coated insoluble carrier system is formed by complexing between surfaces, which provides a sustained release. In this direction, Gastroretentive drug delivery, Pregabalin, Pectin, HPLC, FT-IR, BET, XRD https://www.ijper.org/article/56/1s/S105-S114 2026-04-13T05:54:30.538377+00:00 In silico Evaluation of Selected Compounds from Bergenia ciliata (Haw.) Sternb against Molecular Targets of Breast Cancer 2022-01-12 10.5530/ijper.56.1s.49 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1s-105.pdf Background: A daunting public health issue that mainly affects women is breast cancer. Resistance to drugs applied in the treatment of this cancer as well as their side effects have made it necessary to look for new therapeutic agents. Objectives: The study is aimed at identification of multi-targeted inhibitors of molecular targets associated with breast cancer. Methods: We investigated fifteen compounds from Bergenia ciliata (haw.) Sternb against four major molecular targets of breast cancer v Bergenia ciliata, Breast cancer, In silico, Molecular docking, ADME https://www.ijper.org/identifying-natural-therapeutics-against-diabetes-via-inhibition-of-dipeptidyl-p 2026-04-13T05:54:30.538377+00:00 Identifying Natural Therapeutics against Diabetes via Inhibition of Dipeptidyl Peptidase 4: Molecular Docking and MD Simulation Study 2022-01-12 10.5530/ijper.56.1s.39 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1s-21.pdf Background: As per the International Diabetes Federation statistics 2019, about 463 million people aged between 20-79 years have diabetes, in which mortality of 1.6 million individuals have been recorded each year, especially in developing and economically impoverished countries. Despite the people’s equal access to basic facilities of appropriate healthcare systems and lifesaving drugs, it is desirable to accelerate the identification and development of natural drug candidates, prophylactically Diabetes, Dipeptidyl peptidase 4, Natural therapeutics, Molecular docking, MD simulation, Sustainable development goals https://www.ijper.org/knowledge-and-attitude-of-taif-university-students-on-stem-cell-banking 2026-04-13T05:54:32.055025+00:00 Knowledge and Attitude of Taif University Students on Stem Cell Banking 2022-01-01 10.5530/ijper.56.1.35 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-296.pdf Background and Objectives: The awareness of university students is pivotal to the adaptation of new therapeutic technologies in combating illness and disorders. Stem cells are unique and effective in treating several pathological conditions. This study was an effort to determine the knowledge and attitude of Taif University students toward the banking of stem cells through the donation of umbilical cord blood (UCB). Materials and Methods: The study used a self-administered questionnaire that con Knowledge, Attitude, Taif University, Awareness campaigns, Umbilical Cord, blood https://www.ijper.org/optimization-of-a-validated-uv-spectrophotometric-methodology-for-assessment-of 2026-04-13T05:54:32.055025+00:00 Optimization of a Validated UV-Spectrophotometric Methodology for Assessment of Apigenin in Bulk Powder 2022-01-01 10.5530/ijper.56.1.33 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-281.pdf Introduction: Apigenin (4,5,7 Trihydroxyflavone) is a natural compound of flavonoids class, which is found in various plant constituents. Since primitive years, Apigenin has been used as a traditional medicine, because it possesses biological functions. Common ayurvedic formulations comprising apigenin are in market. Hence quality control of preparation covering apigenin is desirable. Objectives: In present study, pointed to enhance and validate UV Spectrophotometric method to evaluation of apig Apigenin, Absorbance, ICH guidelines, Ruggedness, Spectrophotometric, Ayurvedic Formulations https://www.ijper.org/solid-dispersion-of-artemether-in-fast-disintegrating-tablet-to-enhance-dissolut 2026-04-13T05:54:32.055025+00:00 Solid Dispersion of Artemether in Fast Disintegrating Tablet to Enhance Dissolution Rate and Oral Bioavailability 2022-01-01 10.5530/ijper.56.1.18 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-153.pdf Objectives: Artemether (ART), an antimalarial drug, have poor solubility and low bioavailability. Therefore, solid dispersion of the drug was formulated using Soluplus (SOL) and was incorporated in the fast disintegrating tablet. Materials and Methods: The solid dispersion (SD) was prepared using the solvent evaporation method using a rotary evaporator. The optimized SD was evaluated and then incorporated into the tablet. Results: Solubility studies revealed that ART SD A3 of ratio 1:3 (ART: SOP Artemether, Solid dispersion, Fast disintegrating tablet, Malaria, in-vivo, study https://www.ijper.org/article/56/1/215-223 2026-04-13T05:54:32.055025+00:00 Hydroxychloroquine Metabolites – An Exploratory Computational Study 2022-01-01 10.5530/ijper.56.1.25 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-215.pdf Background: HCQ has been found to provide the immunomodulation that helps to abate the possible cytokine storm response caused by the SARS COVID-19 virus and subsequent failures of major organs. It is also being used historically in treating Malaria and Rheumatoid arthritis and is known to be useful in cancer treatment. However, it shows a half-life of up to 70 days and has severe adverse effects including gastric disorders and retinopathy. Hypothesis: Therefore, we propose to explore some of it Hydroxychloroquine metabolites, COVID-19 drugs, Computational, ADME, studies, Rheumatoid arthritis, Immunomodulation https://www.ijper.org/article/56/1/207-214 2026-04-27T10:28:51.042971+00:00 Antioxidant and Antidiabetic Activity of Berberis lycium : The Possibilities of TLC-MS Bioautography and in silico Study 2022-01-01 10.5530/ijper.56.1.24 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-207.pdf Background: Since ancient times, the traditional system of medicine has been practiced and developed an array of defense strategies to manage various ailments. About 60-80 percentof people from different parts of the world rely on herbal medicine for their health care. In the present study, a combined method using TLC mass spectrometry bioautography (TLC-MS bioautography) combined with DPPH and α-amylase activities was utilized to compare antioxidant and antidiabetic activities in an aqueous ext Berberis lycium, TLC-bioautography, Antioxidant, Antidiabetic, in silico https://www.ijper.org/fabrication-and-evaluation-of-gemcitabine-loaded-alginate-microspheres-a-potenti 2026-04-13T05:54:32.055025+00:00 Fabrication and Evaluation of Gemcitabine-loaded Alginate Microspheres: A Potential Approach for Treatment of Various Carcinomas 2022-01-01 10.5530/ijper.56.1.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-086.pdf Aim/background: Microspheres are spherical particles, having a core, having a particle size of 1μm to 1000μm. They are advantageous as compared to conventional dosage forms of drugs, in parameters like sustainability and control of drug release, drug protection, biodegradability, targeting ability and many more. Gemcitabine is a prodrug and is used in various carcinomas. Sodium Alginate and Ethyl Cellulose are used as polymers. The fabrication aims to sustain the drug release which can treat pan Gelation, Targeting, Sustainability, Microspheres, Entrapment Efficiency https://www.ijper.org/in-vivo-wound-healing-activity-of-ointment-based-formulation-for-prunus-amygdalu 2026-04-13T05:54:32.055025+00:00 In vivo wound Healing Activity of Ointment based Formulation for Prunus amygdalus (Batsch.) on Rats 2022-01-01 10.5530/ijper.56.1.21 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-184.pdf Objectives: The present study is to investigate the wound healing activity of F1-PAO and F2-PAE ointment formulations based on Prunus amygdalus oil and extract respectively. Materials and Methods: The ethanolic and n- hexane extract of Prunus amygdalus (Batsch.) Seed (Nut) was done and incorporate to make F1-PAO and F2-PAE ointments formulations. Above formulations were investigated for their wound repairing potential by excision and incision model in Albino wistar Rats. Animals were divided in Prunus amygdalus (Batsch.), Almond, Wound healing, Excision, Incision https://www.ijper.org/preparation-and-characterization-of-transdermal-therapeutic-system-containing-si 2026-04-13T05:54:32.055025+00:00 Preparation and Characterization of Transdermal Therapeutic System Containing Simvastatin: A Statistical Study 2022-01-01 10.5530/ijper.56.1.14 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-112.pdf Introduction: The purpose of the present study was to design, develop, and characterize the transdermal patches containing Simvastatin for the management of blood lipid levels. Materials and Methods: Transdermal patches of Simvastatin were prepared by the solvent casting method. The prepared patches were evaluated for physicochemical characteristics such as thickness, weight variation, folding endurance, percentage moisture uptake, percentage moisture content, percentage drug content, and ex-viv Transdermal patches, Simvastatin, Factorial designs, Matrix, Eudragit https://www.ijper.org/solid-dispersion-of-lumefantrine-using-soluplus-by-solvent-evaporation-method-fo 2026-04-13T05:54:32.055025+00:00 Solid Dispersion of Lumefantrine Using Soluplus® by Solvent Evaporation Method: Formulation, Characterization and in-vitro Antimalarial Screening 2022-01-01 10.5530/ijper.56.1.15 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-121.pdf Objectives: Lumefantrine (LUM) is an antimalarial drug having poor aqueous solubility. The objective was to formulate the solid dispersion of LUM and improve the solubility and dissolution rate. Materials and Methods: Solvent evaporation technique was used to prepare solid dispersions (SDs) with Soluplus® (SOL) using a rotary evaporator. The feasibility of the formation of SD for LUM and SOL was assessed by the Hansen solubility parameter. The drug solubility was analyzed by the HPLC method and Lumefantrine, Soluplus, Solubility enhancement, Dissolution rate, Antimalarial, screening https://www.ijper.org/article/56/1/43-49 2026-04-13T05:54:32.055025+00:00 Formulation and Evaluation of Film Forming Solution of Diphenhydramine Hydrochloride for Transdermal Delivery 2022-01-01 10.5530/ijper.56.1.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-043.pdf Aim: The present work intends to formulate and evaluate film forming solution of diphenhydramine. Materials and Methods: Film forming solutions (FFS) for transdermal delivery of Diphenhydramine HCl were prepared using different polymers (hydroxypropyl cellulose, Eudragit L 100, polyvinylpyrollidone K30 and polyvinylpyrollidone K90), PEG 400 as plasticizer and ethyl alcohol as solvent. Results: The film forming solutions were found to display an acceptable drying time ranging from 2 to 5 min. In- Film forming solution, Diphenhydramine HCl, Antihistamine, Transdermal, delivery, Shed snake skin https://www.ijper.org/article/56/1/1-8 2026-04-13T05:54:32.055025+00:00 Development of Magnetic Nanoparticles and Encapsulation Methods – An Overview 2022-01-01 10.5530/ijper.56.1.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-001.pdf Nanotechnology is a versatile evolving field today. The importance of nanoparticles reaches high in diagnostics, medicine, or pharmaceuticals for drug delivery. Among all the different nanoparticles, Magnetic nanoparticles are novel, easily prepared, and have many biomedical applications. The specific character of Magnetic nanoparticles shows various applications like a diagnosis of diseases, targeted drug delivery, and cancer therapy. An overview of this topic includes all about the history, ad Applications, Characterization, Magnetic nanoparticles, Nanoparticles, Preparation methods https://www.ijper.org/telepharmacy-knowledge-perceptions-and-readiness-among-future-malaysian-pharmaci 2026-04-13T05:54:32.055025+00:00 Telepharmacy Knowledge, Perceptions, and Readiness among Future Malaysian Pharmacists Amid the COVID-19 Pandemic 2022-01-01 10.5530/ijper.56.1.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-009.pdf Background: Telepharmacy is a relatively recent advancement in healthcare services that enables providing high-quality pharmacy services to rural and remote areas. It gained increased attention during the COVID19 pandemic. Objectives: To assess the knowledge, perceptions, and readiness towards telepharmacy services among senior pharmacy students in a Malaysian public pharmacy school. Materials and Methods: A cross-sectional study was conducted using a self-developed, pre-tested, and validated 35 Malaysia, Pharmacists, Readiness, Students, Telepharmacy https://www.ijper.org/article/56/1/17-23 2026-04-13T05:54:32.055025+00:00 Perspectives of Pharmacy University Students on Scientific Research in Comparison to Students from Other Health Science Disciplines 2022-01-01 10.5530/ijper.56.1.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-017.pdf Background: The value of scientific research should be instilled in students from the very beginning of their university education, to foster a creative attitude in the next generation. It is critical to promote a research culture using various technologies and strategies. Purpose: The purpose of this study was to assess students’ perspectives towards scientific research and to learn more about the obstacles they confront in this area. Methods: Students at the Colleges of Medicine (COM), Pharmac AlMaarefa University, Obstacles, Practices, Perception, Scientific Research, University students https://www.ijper.org/formulation-and-evaluation-of-natamycin-solid-dispersion-incorporated-ophthalmic 2026-04-13T05:54:32.055025+00:00 Formulation and Evaluation of Natamycin Solid Dispersion Incorporated Ophthalmic Films 2022-01-01 10.5530/ijper.56.1.13 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-103.pdf Background: The aim of this study was to enhance the solubility of Natamycin, an antifungal agent used in fungal keratitis, through solid dispersion incorporated ophthalmic films with the purpose to avoid frequent dosing, enhance the period of retention, and sustaining release for better patient compliance. Materials and Methods: Firstly, solid dispersions were prepared by the solvent evaporation method and then, the best solid dispersion formulation was incorporated into films which were prepar Ophthalmic films, Natamycin, Ethyl cellulose, PVA, Chitosan https://www.ijper.org/preparation-and-in-vitro-in-vivo-characterization-of-transdermal-amphiphilogel-l 2026-04-13T05:54:32.055025+00:00 Preparation and in-vitro / in-vivo Characterization of Transdermal Amphiphilogel Loaded with Biodegradable Polymeric Submicron Carriers of Meloxicam for Treatment of Inflammation 2022-01-01 10.5530/ijper.56.1.16 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-133.pdf Aim: The main purpose for this study was to develop and evaluate amphiphilogels loaded with meloxicam-submicron particles considering the benefits of the transdermal route of administration of anti-inflammatory drugs (nonsteroidal). Materials and Methods: Glyceryl monostearate (7%, 9% and 11% w/w) and sorbiton monostearate (span 60; 21%, 23% and 25% w/w) amphiphilogels containing meloxicam-submicron particles equivalent to 0.5% w/w drug were formulated. Then these were evaluated through rheologi Transdermal, Submicron carriers, Ampiphilogel, Bioavailability, Antiinflammatory https://www.ijper.org/in-silico-and-molecular-docking-studies-of-black-pepper-phyto-constituents-again 2026-04-27T10:28:15.858724+00:00 In silico and Molecular Docking Studies of Black Pepper Phyto-constituents against EmrD Efflux Pump of E. coli 2022-01-01 10.5530/ijper.56.1.23 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-199.pdf Multidrug resistance (MDR) bacterial infection is the next pandemic waiting behind the COVID-19 with annual mortality rate 700000 worldwide. Among the MDR bacteria, Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterococcus faecium and Enterococcus faecalis are showing average resistance of 50 to 80% to ampicillin, amoxicillin, third-generation cephalosporin’s and fluoroquinolone and even to combinations antibiotics such as amoxi Multidrug resistance (MDR), Piperine, In silico molecular docking, Efflux, pump, E. coli, Black pepper, Amoxicillin https://www.ijper.org/evaluation-of-hepatoprotective-potential-of-stem-bark-of-neolamarckia-cadamba-ag 2026-04-27T10:27:44.85426+00:00 Evaluation of Hepatoprotective Potential of Stem Bark of Neolamarckia cadamba against Chloroform and Over dose of Iron Dextran Induced Hepatotoxicity in Experimental Swiss Albino Mice 2022-01-01 10.5530/ijper.56.1.22 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-191.pdf Background: In general, use of herbal medicines are considered as the backbone in traditional system of medicines as it has been used for food, flavoring agents and in the form of medicines. Keeping in knowledge the increasing demand of herbal drugs over their synthetic counter parts and to restrain the worldwide problem of multidrug resistance (MDR) in hepatoprotective activity. Neolamarckia cadamba that is commonly called Cadamb is a standout amongst the most significant therapeutic plants hav Hepatoprotective, Neolamarckia cadamba, Chloroform, Iron dextran, Hepatotoxicity https://www.ijper.org/article/56/1/240-246 2026-04-13T05:54:32.055025+00:00 HPLC Method Development and Validation for the Quantification of Related Impurities in Testosterone Cypionate Active Pharmaceutical Ingredient 2022-01-01 10.5530/ijper.56.1.28 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-240.pdf Aim: The purpose of this research study, is to develop and validate a reverse phase HPLC test method for detecting relevant impurities in Testosterone cypionate (TCY). Materials and Methods: The chromatographic system for separation of related impurities were achieved in Zorbax XDB-C8 (15 cm x 4.6 mm), 5 micron HPLC column utilising gradient elution technique. Water was selected as solvent-A and Acetonitrile was preferred as solvent-B for mobile phase. The method is gradient technique. Column he Testosterone cypionate, Testosterone replacement therapy, Male, hypogonadism, HPLC, Impurity profiling https://www.ijper.org/chemometric-assisted-spectrophotometric-method-development-for-evaluation-of-tor 2026-04-13T05:54:32.055025+00:00 Chemometric Assisted Spectrophotometric Method Development for Evaluation of Torsemide and Eplerenone in their Combined Tablet Dosage Forms 2022-01-01 10.5530/ijper.56.1.30 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-255.pdf Aim: In a present work two drugs Torsemide and Eplerenone were estimated from their combined tablet dosage forms by applying chemometric assisted spectrophotometric method. Methods: The methods are based on chemometrics a (multivariate) method which includes classical least square (CLS) and inverse least square (ILS). These methods were employed for simultaneous determination of Torsemide and Eplerenone in tablet dosage forms without any prior separation of components. For these methods the over Spectrophotometry, Chemometrics, Torsemide, Eplerenone, Classical least, square method, Inverse least square method, Root mean square error of prediction https://www.ijper.org/evaluation-of-cell-death-potential-of-lepidium-sativum-seed-extracts-in-mcf-7-ce 2026-04-13T05:54:32.055025+00:00 Evaluation of Cell Death Potential of Lepidium sativum Seed Extracts in MCF-7 Cells and Molecular Docking-based Correlation of Identified Bioactive Components with Human Caspase-6 Protein 2022-01-01 10.5530/ijper.56.1.19 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-166.pdf Aim and Background: The methanolic extract of Lepidium sativum L. was known for its free radical scavenging potential and anticancer properties. The aim was to perform a comparative investigation of the cytotoxic and cell death potential of the Soxhlet (SOX) and crude methanolic extract (CRU). `Materials and Methods: MTT as well as the PI-based assays in caspase-3-deficient, MCF-7 human breast cancer cells, for its cytotoxic potential and synergistic effect. LC-QTOF-MS/MS was used for characteri Lepidium sativum L, Crude extract, LC-QTOF-MS/MS, Cell-based toxicity, Cell death potential, In-silico analysis https://www.ijper.org/article/56/1/247-254 2026-04-13T05:54:32.055025+00:00 Development and Validation of RP-HPLC Method for Simultaneous Qualitative and Quantitative Estimation of Curcumin and Quercetin in Bulk Mixture 2022-01-01 10.5530/ijper.56.1.29 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-247.pdf Objectives: To design a definite, new and explicit reverse phase high performance liquid chromatographic (RP-HPLC) method for simultaneous estimation of quantitative and qualitative curcumin and quercetin in bulk mixture. As per guidelines of International conference on harmonization (ICH) method was validated. Materials and Methods: In this study, reverse phase analysis was used to do the analysis Younglin- ACME 9000, C18 (250 x 4.6mm i.d) solvent system methanol and 0.05% orthophosphoric acid RP-HPLC, Curcumin, Quercetin, Validation, Qualitative, Quantitative https://www.ijper.org/effect-of-ocimum-sanctum-in-sodium-fluoride-naf-induced-fluorosis-in-rats-a-stud 2026-04-13T05:54:32.055025+00:00 Effect of Ocimum sanctum in Sodium fluoride (NaF) induced Fluorosis in Rats: A Study with Respect to Antioxidant Enzymes and Fluorosis Markers 2022-01-01 10.5530/ijper.56.1.20 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-175.pdf Introduction: Fluoride contamination was observed in groundwater’s of India, Pakistan, China, Indonesia and several other countries. In India the states like Andhra Pradesh, Telangana, Rajasthan, Haryana etc are contaminated with fluoride. Approximately 68 million people are suffering from fluorosis in India. The current study was done to know the antioxidant effect, anti-fluorosis and free radical scavenging property of Ocimum sanctum (OS). Methods: Superoxide dismutase (SOD), glutathione perox Ocimum sanctum, Antioxidant Enzymes, Fluorosis markers, Liver markers, GC-MS analysis, Rats https://www.ijper.org/development-of-validated-stability-indicating-method-for-estimation-of-vandetani 2026-04-13T05:54:32.055025+00:00 Development of Validated Stability Indicating Method for Estimation of Vandetanib and Characterization of its Degradants by LC-ESI-MS 2022-01-01 10.5530/ijper.56.1.27 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-232.pdf Aim: In the current study, stability indicating high performance liquid chromatography method (RP-HPLC) was developed and validated for the determination of Vandetanib, also its major degradants were identified and characterized by Liquid Chromatography- Tandem Mass spectrophotometric method (LC-ESI-MS). Methods and Materials: This method was developed on Nucleosil 100-5, C18 (250×4.6 mm, 5μm) column by using Methanol: Ammonium acetate buffer as Mobile phase in the ratio, 90:10 v/v, having flow Mass Spectroscopy (MS), Vandetanib, High-Performance Liquid, Chromatography (HPLC), Validation, Stress degradation https://www.ijper.org/article/56/1/272-280 2026-04-13T05:54:32.055025+00:00 Spectroscopic Substantiation for the Identification of Degradants by Q-TOF Micromass (ESI-MS) in Bisoprolol Fumarate with an Inventive Validation Approach for Stability Indicating HPLC Method 2022-01-01 10.5530/ijper.56.1.32 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-272.pdf Background: Stability studies, stress testing of drug substances and finished drug product is obligatory due to the guidelines by the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) and other Regulatory Authorities. Materials and Methods: In the present work the selective Beta-1 receptor blocker, Bisoprolol fumarate was subjected to the forced degradation studies which includes hydrolysis (acidic, basic and neutral), oxidative, photolytic Bisoprolol fumarate, Forced degradation study, Impurity profiling, International, council for Harmonization Q3B https://www.ijper.org/establishment-of-a-rapid-and-highly-sensitive-reverse-phase-high-performance-liq 2026-04-27T10:32:14.43979+00:00 Establishment of a Rapid and Highly Sensitive Reverse-phase High-performance Liquid Chromatography Based Analytical Assay Method for Duvelisib 2022-01-01 10.5530/ijper.56.1.34 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-287.pdf Background: Duvelisib is an antineoplastic agent that received global approval from the United States Food and Drug Administration in 2018. An extensive literature search revealed that analytical method for the quantification of duvelisib at nanogram level is not available till date. A highly sensitive analytical method is necessary to analyze diversified samples containing trace levels of the analyte such as dissolution samples of sustained release formulation, cross-contamination study samples Duvelisib, HPLC, Analytical assay method, Development, Validation https://www.ijper.org/formulation-of-mupirocin-adsorbed-silver-nanoparticle-with-antibiofilm-agents-fo 2026-04-13T05:54:32.055025+00:00 Formulation of Mupirocin Adsorbed Silver Nanoparticle with Antibiofilm Agents for Enhancing Antibacterial Activity 2022-01-01 10.5530/ijper.56.1.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-050.pdf Introduction: Biofilm is a complex structure of microbiome having different bacterial colonies or single type of cells in a group, adhere to the surface to produce infections. Nanoparticles (NPs) are widely used in different technological fields especially medicine because of their antibacterial properties. Silver nanoparticles (AgNPs) possess antimicrobial and antibiofilm property against various microbial infections. Objectives: The main objective of this study was to develop new formulations Staphylococcus aureus, Silver nanoparticles, Mupirocin, Surface adsorption, Antibiofilm https://www.ijper.org/article/56/1/65-76 2026-04-13T05:54:32.055025+00:00 Development of Tapentadol Hydrochloride Loaded Proniosomal Gel using Main Effects Screening Design and in silico Verification using Parameter Sensitivity Analysis 2022-01-01 10.5530/ijper.56.1.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-065.pdf Aim: Tapentadol Hydrochloride is a centrally acting opioid analgesic of biopharmaceutical classification system class I drug. Oral administration of tapentadol hydrochloride undergoes extensive first-pass metabolism leads to poor bioavailability. The present study was aimed to screen the critical material attributes to deliver the tapentadol hydrochloride through the transdermal route using a carrier proniosomal gel. Methodology: Main effect screening design has been constructed to screen the ch Tapentadol, Main effect screening design, Parameter sensitivity analysis, Proniosomal gel, Kolliphore RH 40 https://www.ijper.org/new-approach-of-dipterocarpus-alatus-oil-as-a-permeation-enhancer-in-ibuprofen-g 2026-04-13T05:54:32.055025+00:00 New Approach of Dipterocarpus alatus Oil as a Permeation Enhancer in Ibuprofen Gel 2022-01-01 10.5530/ijper.56.1.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-024.pdf Background: Yang-na tree has a scientific name as Dipterocapus alatus Roxb. Ex G.Don in family Dipterocarpaceae. Many parts of this tree can be used especially for D. alatus oil. Objectives: To develop basic formula of ibuprofen gel composed of D. alatus oil as a permeation enhancement agent from natural source. Materials and Methods: This study composed of formulation development, physico-chemical property testing, permeation study and stability study. Results: The suitable ibuprofen gel formul Dipterocapus alatus, Ibuprofen, Permeation enhancer, Carbopol, Carboxymethylcellulose, Gel https://www.ijper.org/nanostructured-lipid-carrier-a-potential-system-for-enhanced-oral-bioavailabilit 2026-04-13T05:54:32.055025+00:00 Nanostructured Lipid Carrier: A Potential System for Enhanced Oral Bioavailability of Felodipine 2022-01-01 10.5530/ijper.56.1.10 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-077.pdf Background: Felodipine is BCS class II drug with poor and variable bioavailability due to its insolubility in water (19mg/L) and extensive metabolism in liver and gut. Thus, in the study Nanostructured lipid carriers (NLCs) of Felodipine were formulated to improve its solubility and bioavailability. Methods: NLCs loaded with Felodipine were prepared by high shear homogenization with ultrasonication. The NLCs were characterized for particle size, polydispersity index, entrapment efficiency, conte Felodipine, Oleic acid, Compritol ATO 888, High shear homogenizer, Oral, bioavailability https://www.ijper.org/development-and-evaluation-of-nanosuspension-incorporated-in-situ-gel-of-brimoni 2026-04-13T05:54:32.055025+00:00 Development and Evaluation of Nanosuspension Incorporated in situ gel of Brimonidine Tartarate for Ocular Drug Delivery 2022-01-01 10.5530/ijper.56.1.12 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-094.pdf Objectives: The goal of the study was to develop, optimize and in vitro-ex vivo investigation of Brimonidine tartrate nanosuspension incorporated in situ gel formulation to differentiate with marketed (formulation) eye drops for the efficient treatment of glaucoma. Materials and Methods: Nanosuspensions were formulated by solvent evaporation method using probe sonication technique. The effect of the independent variables Tween 80 and Pluronic F68 concentration on Nanosuspension properties were i Brimonidine Tartrate, Ocular bioavailability, Nanosuspension, In-situ gel, Increased residence time https://www.ijper.org/article/56/1/144-152 2026-04-13T05:54:32.055025+00:00 Topical Delivery of Methocarbamol Loaded Nanoemulgel - in vitro Characterization 2022-01-01 10.5530/ijper.56.1.17 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-144.pdf Background: Methocarbamol is used as skeletal muscle relaxant. Nanoemulgel is currently being developed as a transdermal drug delivery technology because to its nanosized droplets, which provide superior effectiveness with reduced toxicity. Aim: The aim of the study is to prepare and characterize the Methocarbamol loaded nanoemulgel. Materials and Methods: The required quantity of Methocarbamol dissolved in Acconon oil, surfactant and co-surfactant used to prepare nanoemulsion with various ratio Methocarbamol, Nanoemulsion, Nanoemulgel, Topical Delivery, In-vitro, characterization https://www.ijper.org/development-and-validation-of-a-precise-rp-hplc-method-to-determine-gentiopicros 2026-04-13T05:54:32.055025+00:00 Development and Validation of a Precise RP- HPLC Method to Determine Gentiopicroside Content in Cultures of Gentiana kurroo Royle 2022-01-01 10.5530/ijper.56.1.31 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-264.pdf Background: Gentipicroside (GPD) is a major bioactive seco-iridoid glycoside in the methanolic extracts of roots and rhizomes of Gentiana kurroo Royle. GPD has antiinflammatory, antidiabetic, analgesic, antinociceptive, antibacterial and free radical scavenging activities. Although this compound was analyzed by various methods in different Gentiana species previously, no valid method was documented describing the accuracy and precision for the detection and quantification of GPD from in vitro sa Gentiopicroside, RP-HPLC method development, Validation, In vitro cultures, Gentiana kurroo https://www.ijper.org/sun-protection-factor-activity-of-black-glutinous-rice-emulgel-extract-oryza-sat 2026-04-13T05:54:32.055025+00:00 Sun Protection Factor Activity of Black Glutinous Rice Emulgel Extract (Oryza sativa var glutinosa) 2022-01-01 10.5530/ijper.56.1.36 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-302.pdf Background: Recently, emulgel has emerged as a potential hydrophobic drug delivery method. Therefore, this study aims to evaluate the phytochemical content of Oryza sativa extract and develop an emulgel formulation using Carbapol 940 as a gelling agent. Materials and Methods: The emulsion was placed in a gel basis after preparation and the formulations were evaluated for their rheology, pH, spreading coefficient, stability, and sun protection factor. Then, phytochemical analysis of O. sativa ext Oryza sativa, Emulgel, Sun Protection Factor, Ultraviolet, Phytochemical, compounds https://www.ijper.org/forced-degradation-of-flibanserin-bulk-drug-development-and-validation-of-stabil 2026-04-13T05:54:32.055025+00:00 Forced Degradation of Flibanserin Bulk Drug: Development and Validation of Stability Indicating RP-HPLC Method 2022-01-01 10.5530/ijper.56.1.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-032.pdf Background: Flibanserin had been approved as the first drug by United State Food and Drug Administration (USFDA) for the treatment of female sexual interest/arousal disorder of any severity. However, the stability of this drug has yet to be studied extensively. Objectives: The objectives of this study were to optimize the stability indicating method and evaluate the stability of flibanserin under various forced degradation conditions, determine the order of the degradation kinetics, half-life an Forced degradation, Flibanserin, Degradation, Active pharmaceutical, ingredients, HPLC, Impurities, oxidation, Degradation kinetics, Stability indicating method https://www.ijper.org/smart-spectrophotometric-method-development-for-simultaneous-estimation-of-antid 2026-04-13T05:54:32.055025+00:00 Smart Spectrophotometric Method Development for Simultaneous Estimation of Antidiabetic Drugs in Formulations 2022-01-01 10.5530/ijper.56.1.26 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-224.pdf Background: An anti-diabetic formulation consisting of vildagliptin and remogliflozin was prescribed for better glycemic control. In the present study a simple, rapid derivative spectrophotometric methods were evolved to analyze these two analytes from the formulations. Methods: Two processed UV spectrophotometric methods were established by measuring the peak amplitude at zero-crossing of second derivative spectra of analytes. The second procedure comprehends the generation of zero - order spec Antidiabetics, Vildagliptin, Remogliflozin, Derivative spectrophotometry, Formulation, Validation https://www.ijper.org/effect-of-formulation-variables-on-fabrication-of-risperidone-loaded-nanoparticl 2026-04-13T05:54:32.055025+00:00 Effect of Formulation Variables on Fabrication of Risperidone Loaded Nanoparticles for Sustained Drug Delivery 2022-01-01 10.5530/ijper.56.1.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-56-1-058.pdf Aim/ Background: Risperidone, an atypical antipsychotic agent, is used in the treatment of psychotic disorders due to its lower Extra Pyramidal side Effects (EPS) than conventional antipsychotics. Materials and Methods: The objective of the present investigation is to study the effect of formulation variables using 32 factorial design; on preparation of nanoparticles to provide sustained drug release for a prolonged period of time; enhancing therapeutic efficacy by reducing dose dependent side e Schizophrenia, Risperidone, Nanoparticles, 32 factorial design, Catalepsy https://www.ijper.org/article/55/3s/S751-S764 2026-04-13T05:54:34.036821+00:00 An Experimental Model to Induce Homogeneous and Progressive Pulmonary Fibrosis in Rats 2021-11-28 10.5530/ijper.55.3s.182 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-751.pdf Background: This study aims to develop a new experimental model of pulmonary fibrosis (PF) as an alternative to conventional bleomycin model to overcome its limitations and effectively screened the therapeutic agents. Similarity of new experimental model to human lung fibrosis particularly as uniform and continuous progression has encouraged us to evaluate the usefulness of this system by assessment of anti-fibrotic drug pirfenidone parallel with bleomycin induced PF. Materials and Methods: In n Asthma, Cigarette smoke, Experimental model, Formaldehyde, Pulmonary fibrosis https://www.ijper.org/article/55/3s/S765-S773 2026-04-27T09:56:37.684129+00:00 The Effect of Taxifolin on Acrylamide-induced Oxidative and Proinflammatory Brain Injury in Rats: A Biochemical and Histopathological Study 2021-11-28 10.5530/ijper.55.3s.183 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-765.pdf Purpose: Acrylamide is a well-known environmental toxic compound. Taxifolin belongs to the group of flavonoids that have antioxidant, antimicrobial, anti-inflammatory and anti-carcinogenic properties. In this study, we investigated the effect of taxifolin on acrylamide-related oxidative and proinflammatory brain damage. Methods: The experimental animals were divided into three groups: (1) those treated with acrylamide 20 mg/kg p.o., (2) those treated with taxifolin 50 mg/kg p.o. and acrylamide a Acrylamide, Brain damage, Inflammation, Neurotoxicity, Oxidative stress, Taxifolin https://www.ijper.org/article/55/3s/S807-S813 2026-04-27T09:59:05.838003+00:00 Synthesis, Cytotoxic and Antihyperlipidemic Activities of Some New coumarinyl 4-Thiazolidinone Derivatives 2021-11-28 10.5530/ijper.55.3s.188 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-807.pdf Background: Despite tremendous advancements both in early diagnosis and approaches to treatment, cancer still remains an unconquered problem. The development of new chemotherapeutic agents for the treatment of cancer with fewer side effects is an important goal for medicinal chemists. Hyperlipidemia is a worth-mentioning risk factor in quickly expanding cardiovascular diseases, including myocardial infarction and, furthermore, in stroke. Hence, there is a need to develop new cytotoxic and antihy Coumarins, Schiff bases, 4-Thiazolidinones, Cytotoxic activity, Antihyperlipidemic activity https://www.ijper.org/article/55/3s/S709-S721 2026-04-27T09:54:21.657847+00:00 In-vivo Pharmacokinetic Study, in-vitro Cytotoxic, Cell Cycle Arresting and Proapoptotic Characteristics of Multiple Emulsions for the Co-delivery of Simvastatin and Alendronate Sodium 2021-11-28 10.5530/ijper.55.3s.178 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-709.pdf Purpose: Development of nanocarriers that can provide efficient co-delivery of immiscible hydrophilic/ hydrophobic drugs with established technology for industrial production is crucial. Due to this reason, multiple emulsions (MEs) were selected as the desired carriers to achieve the co-delivery ability of many drugs and the improvement of cancer therapeutic effect. MEs could entrap the drug in the inner oil phase and hence avoid the drug leaking and co-deliver the drugs into the tumor sites. Th Simvastatin, Alendronate Sodium, In-vivo Pharmacokinetic Study, Cytotoxicity Study, Cell cycle arresting, Apoptosis Study https://www.ijper.org/article/55/3s/S681-S692 2026-04-27T09:53:12.973884+00:00 HPMC Polymers and Xanthan Gum Assisted Development and Characterization of Stavudine Extended Release Floating Tablets 2021-11-28 10.5530/ijper.55.3s.175 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-681.pdf Objectives: Stavudine has a low half-life of 0.8-1.5 hr and therefore needs recurrent administration to sustain stable beneficial drug plasma levels. In order to enhance and preserve the stable drug level of stavudine for round the clock, gastroretentive systems (floating low-density formulations that cause buoyancy on the gastric fluid in the stomach) may prove to be advantageous for releasing the drug content from the matrix tablet reservoirs for several hours. Materials and Methods: The curre Original Article https://www.ijper.org/article/55/3s/S664-S671 2026-04-27T09:50:18.167528+00:00 Interactive Teaching in Higher Education for Effective Knowledge Dissemination and Improved Student Participation 2021-11-28 10.5530/ijper.55.3s.173 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-664.pdf The present generation of students has information at their hands with the advances in technology. The conventional teaching in monologue manner, just delivering bookish information and dictation are ineffective to inculcate knowledge and confidence in them. Attendance is another major challenge for the current educational system. Assessment patterns have improved from ‘marking’ to ‘continuous grading’ systems. However, the questions in examinations merely evaluate the memorizing and writing ski Interactive, Teaching, Learning, Thinking, Examination https://www.ijper.org/article/55/3s/s652-s663 2026-04-27T09:49:50.510629+00:00 Pharmacy Educationists on Post-COVID-19: A Lockdown Exit Preparedness Survey 2021-11-28 10.5530/ijper.55.3s.172 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-652.pdf Purpose: Most of the educational institutions are now closed in many parts of the world due to the pandemic outbreak of COVID-19. Rebooting the institutions, at the times when an effective therapy or vaccine is still awaited, is very risky. The aim of the study was to assess the post-COVID-19 lockdown exit preparedness of Indian pharmacy educationists. Basic procedures: Pharmacy academicians were included in the study to assess their preparedness for the post-COVID-19 lockdown exit using a cross SARS-CoV-2, COVID-19, Pandemic preparedness, Educational institution, Social distancing, Education https://www.ijper.org/article/55/3s/s623-s629 2026-04-27T09:47:21.773957+00:00 Formulation of Resveratrol Nanoemulsion by Phase Inversion Technique and Evaluation of Anti-Cancer Activity on Human Colon Cancer Cell Lines 2021-11-28 10.5530/ijper.55.3s.168 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-623.pdf Colorectal cancer is in third place among the most usually detected cancer worldwide. Many natural compounds have been proved for its efficacy in the treatment of different types of carcinomas. Resveratrol a polyphenolic phytoalexin found in several sources including grapes, berries, etc. Like most of the polyphenols resveratrol also exhibits poor aqueous solubility and hence bioavailability. In this study nanoemulsion of resveratrol has been formulated using a low energy technique (phase invers Resveratrol, Lung cancer, HCT-166 cells, Nanoemulsion, Phytochemicals https://www.ijper.org/article/55/3s/S733-S741 2026-04-13T05:54:34.036821+00:00 Mucoadhesive Microspheres of Atorvastatin Calcium: Rational Design, Evaluation and Enhancement of Bioavailability 2021-11-28 10.5530/ijper.55.3s.180 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-733.pdf Background: Atorvastatin Calcium (ATC) used for lowering the cholesterol levels in body. It is competitive inhibitor of hydroxyl methylglutaryl-coenzyme A (HMG-CoA) reductase, followed mevalonate pathway, which have low bioavailability and poor solubility. Present work focus on development of mucoadhesive microspheres of atorvastatin calcium, for improve the delayed transit, continuous longer period release and preclinical pharmacokinetic estimation in rabbit. Materials and Methods: Microsphere Atorvastatin calcium, Mucoadhesive, Microspheres, Colon targeting, Bioavailability https://www.ijper.org/article/55/3s/S825-S836 2026-04-13T05:54:34.036821+00:00 Development and Validation of a Rapid and Sensitive Stability-indicating RP-HPLC Method for Resveratrol Quantification in Pharmaceutical Formulation 2021-11-28 10.5530/ijper.55.3s.190 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-825.pdf Background: Trans-resveratrol (RVT) is a phytoconstituent belonging to the family of polyphenols, extensively studied for its numerous health benefits. However, its susceptibility for photolytic, oxidative, and hydrolytic degradation, hinders the quantification of RVT present in different formulations. In the present study, a novel, precise, simple, reproducible, accurate, and stability indicating reversed-phase high performance liquid chromatography (RP-HPLC) method was developed and validated Trans-resveratrol, RP-HPLC, Method validation, Force degradation, Specificity https://www.ijper.org/article/55/3s/S837-S843 2026-04-27T10:00:10.081856+00:00 Simultaneous Estimation of Pregabalin and Etoricoxib using Novel HPLC Method: An Application in Quantitative Analysis of Pharmaceutical Dosage Forms 2021-11-28 10.5530/ijper.55.3s.191 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-837.pdf Introduction: A new optimised method was developed for simultaneous estimation of new FDA approved drugs using RP-HPLC method that would emphasize the use of these drugs in various industries for quality measurements. Objectives: The objective of the present study to develop and validate a new simple, novel, precise, rapid, reliable, accurate and reproducible reverse-phase high-performance liquid chromatography (RP-HPLC) technique for simultaneous estimation of Pregabalin (PREG) and Etoricoxib ( Pregabalin, Etoricoxib, Method Validation, Simultaneous, ICH https://www.ijper.org/article/55/3s/S742-S750 2026-04-27T09:55:48.211998+00:00 Anti-metastatic and Anticancer Potentials of Synthesized Chalcones in B16-F10 Melanoma Cells Induced Metastatic Lung Cancer in C57BL/6 Mice 2021-11-28 10.5530/ijper.55.3s.181 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-742.pdf Aim/Background: Metastasis is the main reason of death in cancer with a key challenge to target it precisely by the available treatments. The current study was designed to assess the anti-metastatic potentials of the synthesized chalcones, Ch-1 and Ch-2. Materials and Methods: In vitro study included cytotoxicity, scratch wound assay and cell cycle analysis of Ch-1 and Ch-2. In vivo study was performed in C57BL/6 mice in a B16-F10 induced metastatic lung cancer model. Results: Ch-1 was found to Chalcones, Anticancer, B16-F10 melanoma cells, Metastatic lung cancer, Cell Cycle https://www.ijper.org/article/55/3s/S814-S824 2026-04-13T05:54:34.036821+00:00 Bio-Analytical Method Development for Estimation of Levofloxacin: Application in Estimation of Drug in Nano-formulations and Pharmacokinetic Studies 2021-11-28 10.5530/ijper.55.3s.189 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-814.pdf Aim/Background: Levofloxacin is a safe antibiotic for various inflammatory disorders and a rapid analytical method for various samples reduces the estimation time as well as injects efficiency in the system. The developed method uses minimal solvents with least preparation time also helps in reducing the errors generated by the analyst during processing. Materials and methods: RP-HPLC method was developed for estimation of levofloxacin using Box Behnken Design. The PDA detector was set at 295nm Bioanalytical method, Robustness, Specificity, Stability, ICHQ2R1 https://www.ijper.org/article/55/3s/s637-s645 2026-04-13T05:54:34.036821+00:00 Self-reported Anxiety and Coping: A Cross-Sectional Study among Saudi Nursing Students during COVID-19 Pandemic using GAD-7 and Briefcope 2021-11-28 10.5530/ijper.55.3s.170 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-637.pdf Background: Anxiety is seen among students even during normal times. The COVID 19pandemic is believed to have increased anxiety and depression among the students. Purpose: An investigation was done to assess the anxiety levels and coping strategies of nursing students in Saudi Arabia. The influence of demographics on the anxiety levels and coping strategies were also determined. Methods: A cross-sectional study was conducted using a questionnaire through Google forms. The questionnaire had items Anxiety, Coping strategy, Factorial analysis, linear regression, Variance, nursing students https://www.ijper.org/article/55/3s/S784-S789 2026-04-13T05:54:34.036821+00:00 Preparation and Standardization of Vaginal Suppository from Punica granatum Flower Extract Known as “Golnar” in Persian Medicine 2021-11-28 10.5530/ijper.55.3s.185 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-784.pdf Background: Punica granatum L. flower, known as “Persian Golnar”, is used in Persian medicine to treat excessive menstrual bleeding. Most therapeutic activities of pomegranate are due to the presence of phenolic compounds such as ellagitannins and gallotannins. Aim: This study served the purpose of developing and standardizing P. granatum vaginal suppository. Materials and Methods: Total phenolic and tannin content were assessed for both the extract and the final formula. Moreover, physicochemic Menorrhagia, Punica granatum Flower, Vaginal Suppository, Total Phenolic Compounds, Total Tannins https://www.ijper.org/article/55/3s/S700-S708 2026-04-13T05:54:34.036821+00:00 Forced Degradation Studies of Drospirenone: Isolation and Characterization of Degradation Products 2021-11-28 10.5530/ijper.55.3s.177 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-700.pdf Aim and Objectives: To remain safe for further processing or human consumption, study of stressed degradation for the identification of feasible degradants is required. The stability indicating high performance thin layer chromatographic method was developed with Camag HPTLC system. Materials and Methods: Silica C60F254 precoated TLC plates were used as stationary phase for separation of degradation products. The optimized mobile phase system consist of toluene: methanol: diethylamine (7:3:0.1) Drospirenone, Characterization, Forced degradation studies, in silico toxicity study, Degradation products of drospirenone https://www.ijper.org/article/55/3s/s646-s651 2026-04-27T09:49:34.251451+00:00 Titration of Antibodies and Application of the KAP Strategy for Hepatitis B in Students and Teachers 2021-11-28 10.5530/ijper.55.3s.171 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-646.pdf Aim: Hepatitis B can be prevented through a complete vaccination scheme. In clinical practice, dentistry personnel is 6 times more likely to get this disease than people who perform other activities. To determine the level of protection and establish the degree of knowledge, attitudes, and practices (KAP) against Hepatitis B in the students and clinical lecturers in a dental clinic. Methods: Descriptive cross-sectional study. For the KAP strategy, a structured survey was applied with 15 question Hepatitis B, Antigen, Antibody, ELISA, Hemodialysis https://www.ijper.org/article/55/3s/S722-S732 2026-04-13T05:54:34.036821+00:00 Detailed Research on a Comparative Evaluation of Diclofenac Sodium Tablets Manufactured by Using DC Grade Excipients and Wet Granulation Methods 2021-11-28 10.5530/ijper.55.3s.179 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-722.pdf Aim: The foremost aim of the present study was to formulate a Diclofenac Sodium tablet of 50mg using the direct compression method with directly compressible (DC) grade excipient and the wet granulation method. Materials and Methods: Comparative study of evaluation parameters like micromeritic properties of directly compressible powder blends and granules obtained by wet granulation was carried out to analyze the suitable method for tabletting. Evaluation parameters such as tablet description, h Direct compression, Directly compressible (DC) grade excipients, Wet granulation, Scanning Electron Microscopy (SEM), Surface morphology, Hold time stability study https://www.ijper.org/article/55/3s/s630-s636 2026-04-13T05:54:34.036821+00:00 Knowledge and Attitude toward the Therapeutic Potential of Human Amnion Stem Cells among Students of Taif University, Saudi Arabia 2021-11-28 10.5530/ijper.55.3s.169 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-630.pdf Background: Among the various types of stem cells which have been suggested for therapeutic purposes, human amnion epithelial cells (hAEC) are highly promising. Purpose: This study aims to assess the knowledge and attitudes of the Taif University population toward the therapeutic potential of hAEC. Methods: This was a cross-sectional study carried out among the students of Taif University. A self-administrated questionnaire was used in this descriptive study. The questionnaire consisted of demog Human amniotic epithelial cells, Knowledge, Attitude, Taif University, Awareness campaigns https://www.ijper.org/article/55/3s/S672-S680 2026-04-13T05:54:34.036821+00:00 Enhancement of Solubility and Dissolution Rate of Atazanavir Sulfate by Nanocrystallization 2021-11-28 10.5530/ijper.55.3s.174 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-672.pdf Objectives: The current objective of the present study was to enhance the solubility and dissolution rate of the antiviral drug atazanavir sulphate by employing nanocrystallization technique. Materials and Methods: The method employed for increment of solubility was nanocrystallization which is based on the reduction of particle size of the drug thereby increasing its solubility and also its dissolution property. Various polymers in different ratios were used like HPMC K15M, PVP K30 and PEG 6000 Atazanavir Sulphate, Nanocrystallization, Solubility Enhancement, Dissolution Enhancement, Antiviral https://www.ijper.org/article/55/3s/S693-S699 2026-04-13T05:54:34.036821+00:00 Thermodynamic Study on Hydrotropic Aggregation Behavior of Theophylline 2021-11-28 10.5530/ijper.55.3s.176 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-693.pdf Objectives: A systematic study is required to enhance the solubility of insoluble fluid drugs that are only sparingly soluble. Hydrotropy may be a distinctive development to reinforce the liquid solubility of poorly water-soluble drugs. Materials and Methods: The term hydrotropic has been wont to designate the rise in the solubility of assorted substances in water because of the presence of enormous amounts of additives. Sodium salicylate, sodium benzoate, and resorcinol are utilized to reinforc Hydrotropy, Theophylline, Solubility, Enhancement Factor, Aggregation Properties https://www.ijper.org/article/55/3s/S798-S806 2026-04-13T05:54:34.036821+00:00 Neuroprotective Effect of Bauhinia variegata Leaf Extract against Colchicine: An Experimental Study on Cognitive Dysfunction and Biochemical Alterations in Mice 2021-11-28 10.5530/ijper.55.3s.187 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-798.pdf Objectives: To study the protective role of Bauhinia variegata ethanolic leaf extract induced by colchicine cognitive dysfunction and the damage of oxidative in Swiss albino mice; to examine the neuroprotective consequence of Bauhinia variegata by conducting behavioral memory tests and to estimate the biochemical parameters by using brain homogenate. Methods: The research was conducted on colchicine induced model for a period of 28 days (4 weeks). Behavioral research was conducted using Elevated Bauhinia variegata, Neuroprotective, Alzheimer’s disease, Colchicine https://www.ijper.org/article/55/3s/S774-S783 2026-04-27T09:57:12.790429+00:00 Evaluation of the Antidote Activity of Nimbu swarasa (Citrus limon Linn.) on Jayapala Seed (Croton tiglium Linn.) Induced Toxicity in Wistar Albino Rats 2021-11-28 10.5530/ijper.55.3s.184 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-774.pdf Background: Seeds of Jayapala (Croton tiglium Linn.) is a toxic compound which is commonly used in several Ayurvedic formulations following proper detoxification methods as mentioned in the Ayurvedic classics. Adarsha nigantu, one of the treatises of Ayurveda explains Nimbu swarasa (Lemon juice) as an antidote for Jayapala. The present study was aimed to determine the antidote activity of Nimbu swarasa (Citrus limon linn.) on Jayapala (Croton tiglium Linn.) seed induced toxicity on Wistar albino Antidote, Jayapala seeds, Nimbu swarasa, Haematological parameters, Histopathological examination, Toxicity https://www.ijper.org/article/55/3s/S790-S797 2026-04-13T05:54:34.036821+00:00 Extraction and Evaluation of Lipid Entrapment Ability of Ocimum basilicum L. Seed Mucilage 2021-11-28 10.5530/ijper.55.3s.186 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3s-790.pdf Background: Overweight, obesity is a serious health problem worldwide and has been becoming an epidemic recently due to the rapid growth of its prevalence. The consequences of obesity are not only its related diseases such as diabetes and cardio vascular disease, but also the effects on global socioeconomic. Aim: In this study, we obtained and evaluated characteristics of Ocimum basilicum L. (OB) seed mucilage which fit for developing a weight control product through several characteristics such High swelling index, Lipid adsorption/absorption, Mucilage characteristics, Ocimum basilicum L., Obesity https://www.ijper.org/article/55/4/1028-1036 2026-04-13T05:54:32.888713+00:00 Identification of Possible Inhibitor Molecule against NS5 MTase and RdRp Protein of Dengue Virus in Saudi Arabia 2021-11-21 10.5530/ijper.55.4.203 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-1028.pdf Background: Non-structural protein 5 (NS5) is considered as an important protein in Dengue viruses (DENVs). It contains N-terminal methyltransferase (MTase) and C-terminal RNA-dependent RNA polymerase (RdRp) domains. NS5 plays a crucial role in the replication of Dengue viruses. Therefore it is considered as an attractive candidate for the development of therapeutics in anti-viral infections and diseases. Aim: The aim of proposed in-silico study was to to screen and identify potential lead molec Dengue virus, Molecular docking, Molecular structure, MTase, NS5, Non-structural viral proteins, RdRp https://www.ijper.org/article/55/4/996-1007 2026-04-13T05:54:32.888713+00:00 Formulation Development and Characterization of Nanoemulsion-based Gel for Topical Application of Raloxifene Hydrochloride 2021-11-21 10.5530/ijper.55.4.200 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-0996.pdf Background: Nanoemulsion-gels are nanosized droplets, and thermodynamically stable oil-in-water dispersion. Raloxifene hydrochloride a selective estrogen receptor modulator currently its more research is being laid on in treatment of diseases in estrogen deficient postmenopausal women. Objectives: The objective of this research was to formulate nanoemulsion-gel of raloxifene for topical delivery. Materials and Methods: The oil, surfactant and cosurfactant were selected on the basis of maximal so Raloxifene hydrochloride, Nanoemulsion gel, Ternary phase diagram, Zeta potential, Permeation https://www.ijper.org/article/55/4/947-956 2026-04-27T10:04:11.4955+00:00 The Measurement Model of the Pharmacy Education Service Quality: An Empirical Quest Based on Two Approaches 2021-11-21 10.5530/ijper.55.4.195 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-0947.pdf Objectives: The objective of this study to build a comprehensive model to measure the service quality of the pharmaceutical institutes in India. At the same time, the author also validates the model with two different approaches of service quality measurement that belongs to gap score and perception-only measure. Materials and Methods: The eight pharmacy institutes are selected randomly from eastern India and then 370 respondents take part in this survey process. The model has been developed wit Pharmacy education, Service Quality, SERVIQUAL, SERVIPERF, Indian Pharmacy Institutes https://www.ijper.org/article/55/4/1164-1172 2026-04-13T05:54:32.888713+00:00 Application of Augmented Simplex Centroid Design for Optimization of HPLC Mobile Phase for Estimation of Curcumin and Piperine 2021-11-21 10.5530/ijper.55.4.216 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-1164.pdf Background: Optimization of mobile phase for high performance liquid chromatography (HPLC) is an exigent task where one factor at a time (OFAT) approach is not preferable as it is time consuming specially for multifaceted samples. The paper describes Augmented Simplex Centroid Design (ASCD) for optimization of ternary mobile phase system for reversed phase HPLC method. The proposed design was utilized for development of mobile phase composition for simultaneous estimation of curcumin and piperin Augmented simplex centroid design, Curcumin, HPLC, Piperine https://www.ijper.org/article/55/4/1145-1150 2026-04-13T05:54:32.888713+00:00 Synthesis, Characterization and Antidiabetic Evaluation of Sulfonamide in Corporated with 1,3,4-Oxadiazole Derivatives 2021-11-21 10.5530/ijper.55.4.214 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-1145.pdf Aim/Background: There is an increasing prevalence of diabetes mellitus throughout the world, and new compounds are necessary to combat this. While the current available antidiabetic therapies are long-term complicated and side effects-prone, this has led to a demand for more affordable, more effective methods of tackling diabetes. Research is focused on finding alternative medicinal remedies with significant antidiabetic efficacy as well as low adverse effects. This study synthesized, characteri In vivo study, 1,3,4-Oxadiazole, Sulfonamide derivative, anti-diabetic agents https://www.ijper.org/article/55/4/1197-1206 2026-04-27T10:15:26.791602+00:00 Evaluation of iceA1 Gene Expression of Helicobacter pylori Risk Factor of Gastric Cancer in Transgenic Brinjal 2021-11-21 10.5530/ijper.55.4.219 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-1197.pdf Background: The advancement of plant biotechnology improved crop production by revolutionizing plant science. Humans were commonly infected by Helicobacter pylori, and it was closely linked to stomach ulcers and cancer. In addition to traditional vaccines for H. pylori, transgenic plants have also been produced to produce its antigens as well as edible and non-edible parts that can produce an immune response after consumption. The protein present in H. pylori associated with virulence (iceA1) is Helicobacter pylori, Transgenic brinjal, iceA1, Agrobacterium, Callus induction, Real-time PCR https://www.ijper.org/article/55/4/957-965 2026-04-27T10:05:06.717715+00:00 Quality of Pharmacotherapy Lectures and Instructor Teaching Skills of the Pharm D Program in India: A Nationwide Survey 2021-11-21 10.5530/ijper.55.4.196 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-0957.pdf Objectives: The present study aimed to evaluate the quality of pharmacotherapy (PT) lectures provided to PharmD students and to assess the teaching skills of the instructors. Materials and Methods: A cross-sectional study was conducted using a self-administered Instructional Skills Questionnaire (ISQ) instrument containing 39 items which was distributed to 1000 PharmD students who completed the PT courses during their third and fourth years of the PharmD program in India during the 2017/2018 aca Clinical pharmacy, Pharmacotherapy, Evaluation, Education, Teaching, India https://www.ijper.org/article/55/4/1037-1047 2026-04-13T05:54:32.888713+00:00 Ameliorative Effects of 3-methyladenine and Chloroquine in 3-nitropropionic-induced Huntington’s Disease like Symptoms in Mice 2021-11-21 10.5530/ijper.55.4.204 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-1037.pdf Aim: To study the effect of 3-methyladenine and chloroquine phosphate on 3-nitropropionic acid induced Huntington’s disease-like symptoms in mice. Materials and Methods: 3-Nitropropionic acid was administered at the dose of 50 mg/kg, i.p. twice daily for 5 days for inducing Huntington’s disease like symptoms. 3-Methyladenine (15 and 30 mg/kg, i.p.) and chloroquine phosphate (25 and 50 mg/kg, i.p.) were administered 30 min before each 3-nitropropionic acid administration. The motor tests includin Huntington’s disease, 3-nitropropionic acid, Autophagy, Chloroquine phosphate, 3-methyladenine https://www.ijper.org/article/55/4/1173-1182 2026-04-13T05:54:32.888713+00:00 Development and Validation of Analytical Method for Quantitative Estimation of Multiple Metal Impurities in Dobutamine Hydrochloride using ICPMS Spectroscopy 2021-11-21 10.5530/ijper.55.4.217 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-1173.pdf Objectives: Primary objective of the present study is to develop and validate an accurate and linear analytical method for precise estimation of Vanadium, Cobalt, Nickel, Arsenic, Cadmium, Mercury, Thallium and Lead elemental impurities present in the Dobutamine Hydrochloride active pharmaceutical ingredient using inductively coupled plasma mass spectrometry. Materials and Methods: Argon gas is used as carrier gas and helium gas as collision gas, 5% nitric acid is used as diluent, plasma gas flo Inductively Coupled Plasma Mass Spectrometer, Elemental Impurities, Method validation, Dobutamine Hydrochloride, International Conference on Harmonization https://www.ijper.org/article/55/4/966-978 2026-04-27T10:05:32.637494+00:00 Application of Experiential Design for Framing Gastroretentive Microsponges of Glipizide: Screening of Critical Variables by Plackett-Burman Design and Optimization by Box-Behnken Design 2021-11-21 10.5530/ijper.55.4.197 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-0966.pdf Introduction: Microsponges provides a proficient drug delivery system for specific delivery in the upper gastrointestinal tract with high drug loading capability. But the formulation is affected by numerous process and design related factors. The intention of the current research work was to formulate and optimize the floating gastroretentive microsponges of glipizide, an antidiabetic drug, with minimum number of experiments, by applying an appropriate experimental design. Methods: The decisive Glipizide, Microsponges, Plackett-Burman design, Box-Behnken design, Antidiabetic https://www.ijper.org/article/55/4/979-988 2026-04-27T10:06:16.467604+00:00 Development of Green Coffee Beans Extract Loaded Anti-aging Liposomal Gel 2021-11-21 10.5530/ijper.55.4.198 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-0979.pdf Background: Green beans of Coffee arabica L. Family: Rubiacea are rich source of polyphenols that prevents the oxidative damage to the skin. In this study, Liposomes were formulated as drug carrier to enhance the skin permeability of polyphenols for topical administration. Materials and Methods: Extracts of green coffee beans were prepared by varying the ratios of methanol and water. Phytochemical analysis and in vitro antioxidant evaluation was conducted on all the extracts to choose the best e Green coffee beans (GCB), Chlorogenic acid, Extract, Liposomes, Antioxidant, Antiaging https://www.ijper.org/article/55/4/939-946 2026-04-13T05:54:32.888713+00:00 Research on the Constructing the Holistic Thinking Mode and Teaching Effect of Pharmacology 2021-11-21 10.5530/ijper.55.4.194 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-0939.pdf Context: As a bridge course between basic medicine and clinical medicine, pharmacology is a compulsory course for students majoring in clinical medicine. Aim: The purpose this teaching is to establish a holistic thinking mode, build student-centered curriculum system by optimizing the teaching design based on the network platform. Design: Construct receptor-based teaching mode. They are based on the network platform, helping students establishing the holistic thinking of medicine. The study incl Pharmacology, Holistic thinking, Receptor-based, Network platform, Teaching effect https://www.ijper.org/article/55/4/1060-1065 2026-04-13T05:54:32.888713+00:00 Influence of Telmisartan on Pharmacodynamic and Pharmacokinetic Properties of Glimepiride-metformin Combination Using Rodent and Non-Rodent Models 2021-11-21 10.5530/ijper.55.4.206 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-1060.pdf Aim: The present study was planned to evaluate the pharmacodynamic and pharmacokinetic interactions between telmisartan and glimepiride + metformin in single and multiple dose studies using rats and rabbits. Materials and Methods: The blood samples were collected from the rats/ rabbits from retro orbital/ marginal ear vein respectively. The serum glucose, plasma insulin and serum glimepiride were estimated at respective time intervals in all treatment groups. Results: The single and multiple dos Telmisartan, Glimepiride, Metformin, Pharmacokinetics, Pharmacodynamics https://www.ijper.org/article/55/4/1207-1223 2026-04-27T10:16:09.319884+00:00 Implementation of Quality by Design (QbD) Approach in Development of QCT-SMEDDS with Combination of AgNPs for Diabetic Foot Ulcer Management 2021-11-21 10.5530/ijper.55.4.220 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-1207.pdf Introduction: Quercetin (QCT) is a flavonoid with antioxidant, potential free radical scavenger, and strong anti-inflammatory activities. These properties of QCT promote wound healing process. Objectives: The present work to investigate the diabetic wound healing efficacy of QCT- loaded self-micro emulsifying drug delivery system (QCT-SMEDDS) and Silver nanoparticles (AgNPs) in combination. Materials and Methods: The QCT-SMEDDS were develop and optimized using D-Optimal design mixture by observi Diabetic foot ulcer, QCT-SMEDDS, Silver nanoparticles, Strat-M, Wound contraction, Histopathology https://www.ijper.org/article/55/4/930-938 2026-04-27T10:03:09.341033+00:00 Computational Fluid Dynamics-The Futuristic Innovation in Pharmaceutical Industry 2021-11-21 10.5530/ijper.55.4.193 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-0930.pdf The review provides an insight into the application of Computational Fluid Dynamics (CFD), a versatile tool for analysis of complex dynamics of air and fluid flow in pharmaceutical operations. The principle of Navier Stokes equation on the explanation of the mathematics on flow of material is outlined in the review. Using the mathematical equations generation of a computer simulated model helps to develop a process, design a device and an operation by fusion of their theoretical background and e Computational fluid dynamics, Navier Stokes equation, Inhaler device, Drying process, Dissolution https://www.ijper.org/article/55/4/1096-1106 2026-04-27T10:10:39.754354+00:00 An Experimental Study Using the Statistical Tool D-optimal Design for the Process Optimization to Enhance the Yield of β-galactosidase from Lactobacillus plantarum 2021-11-21 10.5530/ijper.55.4.210 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-1096.pdf Context: The Novelty of the research is to formulate the probiotic product with low cost submerged fermentation for the mitigation of lactose intolerance. The utilization of substrate enhances the production of β-galactosidase from the potent strain Lactobacillus plantarum by optimizing the media using the response surface methodology tool. This research is expected to result in innovative scientific outcomes leading to the development of lactose-free products cheaply. Aim: The current research β-galactosidase, D-Optimal, SDS-PAGE, Sodium alginate, Lactose hydrolysis https://www.ijper.org/article/55/4/1151-1163 2026-04-27T10:14:03.675053+00:00 1,3,4-thiadiazole Attached 2, 3- disubstituted Thiazolidinones Derivatives: Synthesis and Biological Evaluation 2021-11-21 10.5530/ijper.55.4.215 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-1151.pdf Background: Thiazolidinone derivatives are the subject of prominent importance since they have been seen as valuable intermediates for the formulating/synthesize of different heterocyclic derivatives and it gives various subsidiaries with every extraordinary kind of exercise. What’re more, researches show that derivatives having 1,3,4-Thiadiazole core/nucleus have a wide scope of pharmacological potential that incorporates antifungal, antibacterial, antiviral, anticancer, antitubercular, anticon Schiff base, Thiazolidinone, 1,3,4-Thiadiazole, Molecular docking, Anti-inflammatory, Antimicrobial, Anti-cancer https://www.ijper.org/article/55/4/1084-1095 2026-04-13T05:54:32.888713+00:00 Phytochemical and Pharmacological Exploration of Cyperus articulatus as a Potential Source of Nutraceuticals and Drug Ingredients 2021-11-21 10.5530/ijper.55.4.209 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-1084.pdf Introduction: Cyperus articulatus rhizome has been used in folk medicine by different inhabitants belonging to tropical and subtropical regions. But its metabolite profile and potential pharmacological and food applications were hardly explored. Evaluation of biological activities of Cyperus articulatus metabolites was the objective of the present study. Materials and Methods: In vitro biological studies concerning radical scavenging, reducing activity, food (meat and β-carotene) protection, bio Secondary metabolites, Food model, DNA protection, Enzyme inhibition, Dihydroquercetin https://www.ijper.org/article/55/4/1125-1144 2026-04-27T10:13:29.027234+00:00 In silico Investigation and Molecular Docking Study of Triazolo-thiadiazole Derivatives for Antimicrobial, Anti-inflammatory and Anti-diabetic Activity 2021-11-21 10.5530/ijper.55.4.213 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-1125.pdf Triazolo-thiadiazole and connected fused ring in heterocyclic compounds are of highly interest in potential bioactive molecules. Triazolo-thiadiazole derivatives have lead of organic chemists due to their good biological and chemotherapeutic significance. Research in the field of anti-mycobacterium, anti-inflammatory, anti-diabetic and anti-microbial therapies are ongoing and studies are seeking. Therefore, the discovery of new effective anti-mycobacterium, anti-inflammatory, anti-diabetic and a Triazolo-thiodizole, Antibacterial, Anti-diabetic, Antitubercular, Anti-inflammatory https://www.ijper.org/article/55/4/989-995 2026-04-27T10:06:36.809787+00:00 BioFibGel: A Green Nanotechnology Based Wound Dressing 2021-11-21 10.5530/ijper.55.4.199 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-0989.pdf Aim: Wound is a fragile and complex injury which can be as simple as a minor cut to the deep lesions and traumatic gash. Depending on the patient’s internal and external conditions, wounds can progress backward or forward. Acute hemorrhage and wound infections are the main cause of loss of life in critical conditions of war field or in traumatic accidents. Innovation: BioFibGel bandage/dressing is a green nanotechnology based wound care product which is intended to be used in trauma, combat inju Wound, Haemorrhage, Green nanotechnology, Silver nanoparticles, Wound dressing, Carbon dots https://www.ijper.org/article/55/4/1066-1073 2026-04-13T05:54:32.888713+00:00 Protection of Hesperidin against Methotrexate-Induced Nephrotoxicity may be Mediated by Nrf2/HO-1 Pathway 2021-11-21 10.5530/ijper.55.4.207 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-1066.pdf Background: Methotrexate (MTX), a successfully used chemotherapeutic in the treatment of various malignancies and autoimmune diseases, might cause severe nephrotoxicity. Here, we aimed at investigating possible nephroprotective effects of hesperidin (HES), a flavanone present in citrus fruits, against MTX-induced toxicity. Methods: Rats were divided into control, HES, MTX, and MTX/HES groups, where HES was administered in a dose of 100 mg/kg/day orally for 8 days and MTX in a single i.p. dose of Methotrexate, Hesperidin, Nrf2, HO-1, TNF-α, Caspase 3, BCRP https://www.ijper.org/article/55/4/1183-1196 2026-04-27T10:14:54.175897+00:00 Molecular Characterization of Genetic Diversity of Plasmodium falciparum Associated with Imported Cases of Malaria in Southeastern Region of Saudi Arabia 2021-11-21 10.5530/ijper.55.4.218 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-1183.pdf Growing global international travel has reflected significantly on the number of imported cases of malaria into non endemic regions of the world inclusive of Saudi Arabia were transmission of the disease is significantly controlled. This success in control could be challenged by the influx of imported cases of the disease. This research looks at the genetic diversity in merozoite proteins 1 and 2 (msp 1 and msp 2) of Plasmodium falciparum gene in imported malaria cases. Blood samples collected b Malaria, Imported, Plasmodium falciparum, Merozoite proteins, msp 1, msp 2, Genetic, Diversity https://www.ijper.org/article/55/4/1048-1059 2026-04-13T05:54:32.888713+00:00 Attenuation of Cardiomyopathy Induced in Sub-Chronic Exposure of Acrolein by Sulforaphane via Indirect PPARy Expression Promoter 2021-11-21 10.5530/ijper.55.4.205 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-1048.pdf Sulforaphane (SPN) is reported to activate the Nrf2/Keap1 complex responsible for protein and gene expression promotion of various antioxidant enzymes. The present study examined the role of Nrf2 in modulating other signaling pathways involved in SPN’s attenuation of acrolein (ACL)-induced cardiomyopathy in rats. Forty-two rat was categorized into seven 4-week treatment groups: control, SPN, losartan (LTN), ACL, ACL+SPN, ACL+LTN, and ACL+SPN+LTN. Heart samples were harvested for analysis; cardia Sulforaphane, Losartan, Acrolein, Cardiomyopathy, Oxidative Stress, PPARγ, Nrf2 https://www.ijper.org/article/55/4/1107-1114 2026-04-13T05:54:32.888713+00:00 Protective Effect of Celastrus paniculatus Seed Extract against Lead Acetate Induced Nephrotoxicity in Wistar Rats 2021-11-21 10.5530/ijper.55.4.211 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-1107.pdf Objectives: The plant Celastrus paniculatus is used in the traditional medical practices of India to treat a plethora of diseases. Earlier research on the plant revealed several biological properties and interesting bioactive compounds with significant medicinal uses. Materials and Methods: In this study, the ethanolic extract of the seeds of the plant (EECP) has been investigated against lead acetate (LA) induced nephrotoxicity in Wistar rats. Thirty rats were divided into five groups (n=6) whe Celastrus paniculatus seeds, Free radical scavenging activity, KIM 1, Lead Acetate, Nephro-toxicity, Wistar rats https://www.ijper.org/article/55/4/1017-1027 2026-04-13T05:54:32.888713+00:00 Deciphering the Synergistic Mechanism of Cortistatin towards Cancer Targets Using Network Pharmacology Approach 2021-11-21 10.5530/ijper.55.4.202 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-1017.pdf Steroidal alkaloid cortistatin is a promising marine natural compound isolated from marine sponges Corticium simplex. Experimental studies and clinical evidence have shown that cortistatin and its derivatives have a curative effect in patients with autoimmune disorders, HIV infection and several types of cancer. The objective of our study was to examine the potential cancer-related therapeutic objectives of Cortistatin using a network pharmacology method, which is a computational approach, inclu Cortistatin, Marine natural product, Molecular docking, Network pharmacology, Cancer targets, Pharmacokinetics https://www.ijper.org/article/55/4/1115-1124 2026-04-27T10:11:31.944516+00:00 Screening of Anti-Hyperglycaemic and Anti-Hyperlipidemic Activities of Leaves Extracts of Cassia glauca Lam. on Streptozotocin-Nicotinamide Induced NIDDM Rats 2021-11-21 10.5530/ijper.55.4.212 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-1115.pdf Aim: The objective of the present study was to screen the anti-hyperglycaemic and anti-hyperlipidemic activities of leaf extracts (Pet-ether, Chloroform, Acetone, and Methanol) of Cassia glauca Lam. on streptozotocin-nicotinamide induced NIDDM rats. Methods: Acute oral toxicity of all extracts was carried out with a single dose of 2000 mg/kg in female non-pregnant albino Wistar rats. An oral glucose tolerance test was performed for all extracts in overnight fasted rats. The anti-hyperglycaemic a Cassia glauca, Streptozotocin, Nicotinamide, Glibenclamide, Serum Glucose Level https://www.ijper.org/article/55/4/1074-1083 2026-04-27T10:09:33.928896+00:00 Formulation and Evaluation of the Antidiabetic, Hypolipidemic and Antioxidant Potential of the Tablets of Arbortristoside-A from the Seeds of Nyctanthes arbortristis Linn. 2021-11-21 10.5530/ijper.55.4.208 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-1074.pdf Aim: Literature shows the traditional as well as scientific proven medicinal importance of Nyctanthes arbortristis Linn. In the it was aimed at to formulate and screen the antidiabetic, hypolipidemic and antioxidant properties of the tablets of arbortristoside-A obtained from N. arbortristis seeds. Materials and Methods: Arbortristoside-A was chemically isolated from the seeds’ ethanolic extract of N. arbortristis. The antioxidant property of arbortristoside-A was screened in-vitro by the help o Antioxidant, antidiabetic, tablet, arbostristoside-A, DPPH, streptozotocin, histopathology https://www.ijper.org/article/55/4/1008-1016 2026-04-27T10:07:44.406298+00:00 Sodium-glucose Cotransporter-2 Inhibitors as Modulator of Dipeptidyl Peptidase-4 in Diabetes 2021-11-21 10.5530/ijper.55.4.201 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-4-1008.pdf Background: Genetic disorders such as diabetes have severe implications on human health. Mutation or aberrant activity of different proteins are associated with diabetes. The hyperactivation of the peptidase function of dipeptidyl peptidase-4 (DPP4) strongly correlates with the elevated level of blood glucose in diabetic patients. Aim: Preventing the activity of DPP4 by small molecule modulators is an excellent approach that proposes to curb the aggressiveness of diabetes. Blocking the DPP4 func SGLT2, DPP4, Docking, Diabetes, Ubenimex https://www.ijper.org/article/55/3/924-929 2026-04-13T05:54:35.307177+00:00 Non-Alcoholic Fatty Liver Disease: Taif Populations’ Perspective Based on Knowledge and Attitude Determinants 2021-08-18 10.5530/ijper.55.3.167 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-924.pdf Background: In developed countries, non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver condition. The disease raises the risk of liver-related morbidity and mortality, as well as associated comorbidities. The general public’s knowledge and attitude are critical in developing countermeasures to prevent the spread of the disease. Purpose: This study was done to determine the knowledge and attitude of the general public of Taif city, Saudi Arabia. Materials and Methods: A va Knowledge, Attitude, Taif, NAFLD, Saudi Arabia https://www.ijper.org/article/55/3/872-879 2026-04-13T05:54:35.307177+00:00 Cytotoxicity of Endophytes of Calotropis procera, Solanum nigrum and Forsskaolea tenacissima 2021-08-18 10.5530/ijper.55.3.161 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-872.pdf Aim: Due to the urgent need for anticancer agents, investigation of endophytes of medicinal plants growing in special environments is considered a promising approach for the search of bioactive natural products. Materials and Methods: The ethyl acetate extracts of the cultures of twelve endophytic fungi were isolated from the medicinal plants Calotropis procera fam Apocynaceae, Solanum nigrum fam Solanaceae and Forsskaolea tenacissima fam Urticaceae growing in one of the richest areas of plant b Endophytes, Cytotoxic activity, Medicinal plants, Calotropis procera, Solanum nigrum, Forsskaolea tenacissima https://www.ijper.org/article/55/3/664-676 2026-04-13T05:54:35.307177+00:00 Self-nanoemulsifying Drug Delivery System of Cilnidipine 2021-08-18 10.5530/ijper.55.3.138 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-664.pdf Aim: Self-nanoemulsifying Drug Delivery Systems (SNEDDS) are physically stable, isotropic mixtures of oil, surfactant and co-surfactant. The turbulence generated by peristaltic movements of the GIT causes formation of oil-in-water (o/w) nano-emulsions upon dilution. The objective of this study was to improve solubility and oral bioavailability of Cilnidipine by formulating liquid-SNEDDS. Materials and methods: Capmul PG8 NF, Cremophor RH40, and Transcutol HP were selected as oil, surfactant, and Cilnidipine, 32 factorial designs, Nanosponges, solid SNEDDS, Oral bioavailability https://www.ijper.org/article/55/3/857-862 2026-04-13T05:54:35.307177+00:00 Bacterial Endophyte Inhabiting Durio zibethinus and its Radical Scavenging and Antidiabetic Potential 2021-08-18 10.5530/ijper.55.3.159 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-857.pdf Background: Endophytes, markedly receiving interest and has been detected to be remarkable sources of bioactive metabolites. Endophytes, which are also called as endosymbionts have pulled into consideration in the discovery for novel bioactive compounds that can be utilized as new medications. In the current study, endophyte has been isolated from Durio zibethinus leaves. 16s rRNA partial genome sequencing was used to identify selected endophyte and the obtained bacterial endophytic crude extrac Cronobacter sakazakii, Durio zibethinus, Endophytes, α-amylase, α-glucosidase https://www.ijper.org/article/55/3/846-856 2026-04-13T05:54:35.307177+00:00 Bioassay-Guided Isolation and Structure Elucidation of Bioactive Phytoconstituents with Inhibitory Activity against Carbohydrate-Hydrolyzing Enzymes from the Aerial Parts of Premna odorata Blanco 2021-08-18 10.5530/ijper.55.3.158 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-846.pdf Background: This study aimed to isolate the bioactive components from the aerial parts of Premna odorata Blanco and to evaluate the hypoglycemic potentials of the crude extracts, sub-fractions and final isolate. Materials and Methods: The plant material underwent a series of enzyme assay-guided isolation and purification having the fractions assayed for inhibitory activity against α-amylase using 3,5-dinitrosalicylic acid (DNS) colorimetric method for each stage. H.1 isolate was tested for α-amy Premna odorata, α-amylase, α-glucosidase, Bioassay, Hyperglycemia, Inhibition https://www.ijper.org/article/55/3/823-828 2026-04-13T05:54:35.307177+00:00 Evaluation of Gastroprotective Activity of Qarahine: A Polyherbal Formulation 2021-08-18 10.5530/ijper.55.3.155 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-823.pdf Background and Aim: Qarahine, a polyherbal formulation consisting of natural active ingredients, is used to treat peptic ulcer. The aim of the present study was to investigate the protective effect of qarahine against aspirin (200 mg/kg) and ethanol (5 ml/kg) induced gastric ulcer rat models. Methodology: The pH of stomach contents, numbers of lesions in gastric mucosa, severity score, ulcer index and percentage protection were determined. The stomachs mucosa was also evaluated for morphological Qarahine, Gastroprotective, Aspirin, Ethanol, Ulcer index https://www.ijper.org/article/55/3/894-903 2026-04-27T09:44:39.210664+00:00 Synthesis and Anti-hyperglycaemic Study of Aryl Sulfonate Ester Conjugated 5-arylidene-thiazolidine-2,4-diones 2021-08-18 10.5530/ijper.55.3.164 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-894.pdf Background: Diabetes mellitus, a lifestyle related global health crisis has rapidly engulfed the entire world. In the past, various thiazolidinedione derivatives have been successfully developed for management of diabetes. Materials and Methods: Herein, we report synthesis, characterization (1H-NMR, 13C-NMR and mass spectroscopy methods) of novel aryl sulfonyloxy-5-arylidene thiazolidine-2,4-dione analogues. Anti-hyperglycaemic action (Alloxan-induced method) was performed for evaluating the ant ADME, Anti-hyperglycaemic, Aryl sulfonyloxy-5-arylidenethiazolidine-2,4-dione, Docking, Spectral characterization https://www.ijper.org/article/55/3/709-714 2026-04-13T05:54:35.307177+00:00 Oral Delivery of Purple Sweet Potato (Ipomoea batatas L.) Extract-Loaded Carboxymethyl Chitosan and Alginate Nanocapsule in Streptozotocin-induced Diabetic Mice 2021-08-18 10.5530/ijper.55.3.143 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-709.pdf Background: Insulin therapy is an essential part in diabetes mellitus type 2 treatment, but it has several side effects such as allergy and hypoglycemia. Therefore, alternative treatments are needed, one of which is by using nanocapsules to increase the performance of the drug delivery system. Purple sweet potato contain high anthocyanin levels which has antidiabetic properties. The idea of this research were to determine the potential use of purple sweet potato extract-loaded CMC-Alginate nanoc Alginate, Carboxymethyl Chitosan, Diabetes Mellitus, Nanocapsules, Purple Sweet Potato https://www.ijper.org/article/55/3/756-764 2026-04-27T09:36:22.277702+00:00 Exploring the Neuroprotective Effects of Mechanosensitive Channel Blocker, GsMTX4 in Intracerebral Hemorrhage Model in Rats 2021-08-18 10.5530/ijper.55.3.148 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-756.pdf Aim: The current study explored the usefulness of a mechanosensitive channel blocker, GsMTX4 in intracerebral hemorrhage (ICH)-associated deleterious effects along with the possible mechanisms. Materials and Methods: Type VII collagenase was administered in the right basal ganglia using stereotactic apparatus to induce ICH in rats. The ICH-associated injury was assessed using corner turn and forelimb placement tests (behavioral test); Evans blue extravasation test (blood-brain barrier damage), b Neuroinflammation, Oxidative stress, Intracerebral hemorrhage, Mechanosensitive channels, BDNF https://www.ijper.org/article/55/3/715-727 2026-04-13T05:54:35.307177+00:00 QBD Approach to Predict the in-vivo Performance Based on in-vitro Results using Mucuna pruriens Seed Mucilage as a Novel Tablet Dosage Form Excipient and Dicofenac Sodium as Model drug Candidate 2021-08-18 10.5530/ijper.55.3.144 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-715.pdf Background: Aim of the present study was to put forth certain modifications in Quality by design approach to predict the in-auto performance of dosage form based on in-vivo performance parameter simulation using in-vitro experimentations. Materials and Methods: One factor design was used with prime focus on impact of Mucuna pruriens seed mucilage as excipient on dosage form functionality and applicability. During product development stage, apart from manufacturing variables other impacting param Mucuna pruriens, Seed polymer, Excipient, QbD perspective, Process capability study, Ishikawa diagram, QTPP, CQA https://www.ijper.org/article/55/3/655-663 2026-04-13T05:54:35.307177+00:00 Blended Teaching Practices for Active Learning in Higher Pharmacy Education 2021-08-18 10.5530/ijper.55.3.137 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-655.pdf Background: Blended adoption of active learning practices improves student achievement on average in college. Nevertheless, there have been few studies to date on the effects of detailed factors on learning outcomes. Objectives: The aim of this study was to develop a blended teaching strategy by incorporating methods of team-based learning (TBL) and e-learning into a Pharmaceutical Analysis course for student active learning, and to explore how the practice impacts student learning outcomes. Mat Higher pharmacy education, Blended teaching, Active learning, E-learning, Team-based learning https://www.ijper.org/article/55/3/916-923 2026-04-13T05:54:35.307177+00:00 Perceptions of Pharmacy and Other Health Professional Students toward Interprofessional Education 2021-08-18 10.5530/ijper.55.3.166 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-916.pdf Background: Interprofessional Education (IPE) equips students with a background for multidisciplinary collaboration in health care provision and its success could be influenced by students’ attitudes. Objectives: To assess the readiness and perceptions of pharmacy and other health professional students toward IPE. Methods: A survey was conducted on students of Pharmacy, Medicine, Nursing, Dentistry and Health and Rehabilitation Sciences (HRS) utilizing the 19-item instrument for assessing the Re Interprofessional education, Health professions, Pharmacy students, Middle East, Perceptions, Readiness https://www.ijper.org/article/55/3/782-792 2026-04-13T05:54:35.307177+00:00 Protective Effects of Small Peptides from Periplaneta americana on Cyclophosphamide-induced Oxidative Stress in Rat Ovaries 2021-08-18 10.5530/ijper.55.3.151 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-782.pdf Introduction: Periplaneta americana (P. americana), commonly known as the American cockroach, has shown multiple clinical benefits. Small Peptides from P. americana (SPPA) was found to have promising antioxidative effects in vitro. However, the pharmacological benefits of SPPA demand further in-depth investigation as the underlying mechanism for its antioxidative effect remain unexplored. Objectives: To evaluate the effects of SPPA on ovarian follicles and antioxidant capacity in rats. Materials Small Peptides from Periplaneta americana, Oxidative stress, Gene expression, Ovarian follicle, Cyclophosphamide, Rats https://www.ijper.org/article/55/3/692-700 2026-04-13T05:54:35.307177+00:00 Formulation of Tablets Containing Mesoporous Silica Nanoparticles Loaded with Pramipexole 2021-08-18 10.5530/ijper.55.3.141 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-692.pdf Background: In order to develop final pharmaceutical product, the mesoporous silica particles loaded with pramipexole should be further formulated in the applicable solid dosage forms - tablets. The aim of the study was preparation of tablets containing MCM-41 particles loaded with pramipexole. Materials and Methods: Mesoporous silica particles empty and loaded were subjected to dynamic light scattering analysis (DLS), transmission electron microscopy analysis (TEM) and infrared spectroscopy (IR MCM-41, Pramipexole, Chitosan, Sodium alginate, Modified release https://www.ijper.org/article/55/3/863-871 2026-04-13T05:54:35.307177+00:00 Determination of the Chemical Constituent Contents and Antioxidation Properties of Asystasia Gangetica 2021-08-18 10.5530/ijper.55.3.160 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-863.pdf Background: Asystasia gangetica, also referred to as Chinese Violet is an invasive weed that has been revealed to contain biologically active components and manifest pharmacological effects. Phytochemical analysis on different extracts of A. gangetica reported that the plant contains steroids, sugars, phenolics, flavonoids, saponins, tannins and amino acids, alkaloids, terpenoids, quinines and carbohydrates and bioassay techniques performed using the plant material manifested its antioxidant, an Antioxidation activity, Asystasia gangetica, Condensed tannin, Flavonoids, Polyphenol https://www.ijper.org/article/55/3/888-893 2026-04-27T09:43:53.724469+00:00 Synthesis of Some Glycine Nicotinates and in-vivo Evaluation of Anti-Convulsant Activity for their Brain specific Slow Release Action 2021-08-18 10.5530/ijper.55.3.163 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-888.pdf Aim: Purpose of the present work is to synthesize the pro-pro-drugs of Glycine and evaluate for their anticonvulsant activity in albino rats with brain specific sustained release action in various biological fluids. Materials and Methods: Prepared and synthesized pro pro-drugs of Glycine nicotinate by esterification with different alcohols and admiration with nicotinic acid. In present work pro-prodrug of Glycine nicotinate were synthesized by taking the Dihydropyridine as carrier molecules. The Dihydropyridine, Pro-pro-drug, Nicotinylglycine, Glycine nicotinate, Antiepileptic https://www.ijper.org/article/55/3/s765-s773 2026-04-27T09:37:51.630224+00:00 Network Pharmacology-based on the Active Components and Molecular Mechanisms of Andrographis paniculata (Burm. f.) Wall. ex Nees in Treating Inflammation 2021-08-18 10.5530/ijper.55.3.149 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-765.pdf Background: Andrographis paniculata (Burm. f.) Wall. ex Nees (AP) is a medicinal plant traditionally used as anti-inflammation and anti-bacteria. The role of AP in inflammation has been evaluated in several studies. But, the exact mechanism is unclear. In the present study, network pharmacology was used to explore the anti-inflammation constituents of AP and its anti-inflammation mechanism. Materials and Methods: The chemical components of AP. were screened by TCMSP database, in combination with Andrographis paniculata (Burm.f.) Wall. ex Nees, Network pharmacology, Inflammation, Docking https://www.ijper.org/article/55/3/649-654 2026-04-13T05:54:35.307177+00:00 Model-based Instruction as an Activity in Teaching a Pharmaceutics Course 2021-08-18 10.5530/ijper.55.3.136 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-649.pdf Objectives: Pharmaceutics is the core component of pharmacy education; the course helps pharmacy students to understand the influence of drugs' physicochemical characteristics and manufacturing parameters on therapeutic performance. Although they are important, pharmaceutics concepts can be "dry," especially since many pharmacy schools teach pharmaceutics using the traditional lecture-only format. Therefore, activities through which students can perceive the relevance of the subject to clinical Simulation and education, Modelling and education, Physical models and teaching, Small-group activities, PharmD, Pharmacy education https://www.ijper.org/article/55/3/638-648 2026-04-27T09:25:38.010866+00:00 Gel-forming Mucins in Oviductus Ranae Contribute to Swelling Capacity by iTRAQ Proteomics Analysis 2021-08-18 10.5530/ijper.55.3.135 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-638.pdf Introduction: Oviductus Ranae (OR) is the dried oviduct of female Rana temporaria chensinensis David, which is one of the best-known and highly valued oriental foods and medicines in China. OR has a unique physiological phenomenon that is high swelling capacity. Objectives: We aimed to study which components are associated with high swelling capacity in OR. Materials and Methods: isobaric tags for relative and absolute quantification (iTRAQ) proteomic methods were used to identify differentially Oviductus Ranae, Swelling capacity, Gel-forming mucins, Counterfeit oviducts, Differentially expressed proteins https://www.ijper.org/article/55/3/s793-s800 2026-04-27T09:39:22.271717+00:00 Assessment of Antioxidant Activity of Crude and Purified Bio-active Compound, Embelin in Aegiceras corniculatum (L.) Blanco: A Less-explored Mangrove Plant 2021-08-18 10.5530/ijper.55.3.152 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-793.pdf Context: Most of the Mangrove species are vital basically in terms of economic, environmental and medicinal point of view as several Mangrove species are used for preparation of many drug formulations. In this aspect, Aegiceras corniculatum is a unique black Mangrove plant. Aim: In this study antioxidant potency of different parts of A. corniculatum was evaluated through measuring the antioxidant parameters along with a comparative assessment between the crude extracts and the purified embelin i Aegiceras corniculatum, Antioxidant, DPPH, FRAP, Reducing Power https://www.ijper.org/article/55/3/677-684 2026-04-27T09:27:46.157878+00:00 Enteric Dissolution Enhancement of Engineered Gastro Resistant Omeprazole Tablets using Hydroxypropyl Methylcellulose Acetate Succinate 2021-08-18 10.5530/ijper.55.3.139 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-677.pdf Purpose: Oral drug delivery system has always been a preferred choice for the treatment of peptic ulcer and gastroesophageal reflux diseases. Being a proton pump inhibitor omeprazole restricts gastric acid secretion but the foremost downside is its degradation in acidic environments. The systemic absorption of gastro-unstable drugs can be improved by the enteric coating. Materials and Methods: This study was aimed at developing an effective enteric coating for omeprazole tablets using HPMC E5-LV Proton pump inhibitor, Enteric coating, HPMC, Omeprazole, Dissolution enhancement https://www.ijper.org/article/55/3/685-691 2026-04-13T05:54:35.307177+00:00 Development of a Novel Ionic Liquid Based Microemulsion System for Gemcitabine Hydrochloride and in vitro Evaluation in Human Cervical Cancer HeLa Cells 2021-08-18 10.5530/ijper.55.3.140 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-685.pdf Aim: The aim of this study was to develop novel ionic liquid based microemulsion systems and assessing the in vitro activity against HeLa cancer cell line. Materials and Methods: Four imidazaolium cation based ionic liquids were synthesized and used in the studies. The microemulsions were developed and optimized after studying the phase diagrams comprising isopropyl myristate and different surfactant combinations. The physical characteristics of the prepared formulations were determined by study Gemcitabine, Microemulsion, Ionic liquid, Cervical cancer, Drug delivery https://www.ijper.org/article/55/3/812-822 2026-04-13T05:54:35.307177+00:00 Phytochemical Profiling and in vitro Screening for Neuritogenic and Antioxidant Activities of Spirulina platensis 2021-08-18 10.5530/ijper.55.3.154 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-812.pdf Background: In neurological diseases, neuronal loss is frequently associated with overproduction of free radicals and reduced level of endogenous neurotrophic factors. The blue-green microalga, Spirulina platensis is a well-known superfood with a high content of diverse nutrients and possesses several therapeutic properties. Here, we aimed to study the neuritogenic and antioxidant activities of Spirulina platensis UMACC 159. Materials and Methods: PC-12Adh (rat pheochromocytoma) cell was used to Spirulina platensis, Antioxidants, Cytotoxicity, Neuronal outgrowth, Phytochemicals https://www.ijper.org/article/55/3/728-737 2026-04-27T09:29:47.526491+00:00 Formulation and Evaluation of Sodium Alginate and Guar Gum Based Glycyrrhizin Loaded Mucoadhesive Microspheres for Management of Peptic Ulcer 2021-08-18 10.5530/ijper.55.3.145 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-728.pdf Background: Glycyrrhizin (GZ) is a bioactive ingredient of Glycyrrhiza glabra, reported for various therapeutic effects including gastro-protection. It has been associated with low absorption, early elimination, short half-life and poor bioavailability. Objectives: Aim of the current study was to formulate GZ loaded mucoadhesive microspheres by using mucopolymers like sodium alginate and guar gum for the management of peptic ulcer. Methods: Various GZ loaded microspheres (GZ-MS1-3) were prepared Mucoadhesive microspheres, Glycyrrhizin, Mucopolymers, Sodium alginate, Guar gum, Sustained release, Peptic ulcer https://www.ijper.org/article/55/3/829-836 2026-04-27T09:41:21.203498+00:00 Isolation and Bioactivity Screening of Endophytic Fungi from Commelina diffusa 2021-08-18 10.5530/ijper.55.3.156 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-829.pdf Background: Endophytic fungi are able to produce many secondary metabolites and thus their availability and biological activity created new horizons for different pharmaceutical and agricultural approaches. Objective: For the ethnobotanical antiquity of Commelina diffusa in Bangladesh, this study is aimed at evaluating the endophytic fungal collection of Commelina diffusa and their bioactive potential. Methods: Endophytic fungi were isolated by the surface sterilization technique and identified Endophytic fungi, Fusarium sp., Alternaria sp., Antibacterial, Antioxidant, Cytotoxic activity https://www.ijper.org/article/55/3/738-747 2026-04-13T05:54:35.307177+00:00 Coordinated Androgen and Estrogen-receptor microRNA 26 Directive in Breast and Prostate Tumour 2021-08-18 10.5530/ijper.55.3.146 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-738.pdf MiR-26 is a miRNA tumour suppressor that is frequently dysregulated in many tumour tissues and lines of tumour cells. Androgen and Estrogen receptor (AR & ER) were evolving as a target to examine among hormone proteins since it appears to show a part at numerous phases of growth of breast and prostate cancers. For that kind of reason, AR and ER are becoming very relevant in recent times. Although its position remains problematic in medical care, the various finding had demonstrated a link among Breast cancer, Prostate cancer, microRNA 26, Androgen receptor (AR), Estrogen receptor (ER) https://www.ijper.org/article/55/3/701-708 2026-04-13T05:54:35.307177+00:00 Design of Experiments for Critical Material Attributes Assessment of Linagliptin and Metformin Fixed-dose Combination Tablets 2021-08-18 10.5530/ijper.55.3.142 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-701.pdf Aim of work: This study aimed to determine the amount of excipients in the critical material attributes of linagliptin and metformin sustained release (SR) fixed-dose combination (FDC) tablets using design of experiments (DoE). Methods: A 23 full factorial design with three center points was performed. For the screening of excipients, 3-factor responses (mannitol, sodium starch glycolate and pregelatinized starch for linagliptin; hydroxypropyl methylcellulose, sodium carboxymethyl cellulose (CMC Critical material attributes, Design of experiments, Linagliptin, Metformin, Quality by design https://www.ijper.org/article/55/3/774-781 2026-04-27T09:38:49.866259+00:00 Evaluation of in-vitro Immunomodulatory Activity and Thrombolytic Potential of Kabasura Kudineer (KSK): An Official Siddha Polyherbal Formulation 2021-08-18 10.5530/ijper.55.3.150 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-774.pdf Aim: Coronavirus disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), attacking mainly on the immune system of a body. This has spread mortality and morbidity all over the world. During this dreadful situation there is an urgent need for the development and rapid dissemination of COVID-19 treatment. Siddha’s traditional medicine system can be used as preventive care to boost the immune system. Materials and Methods: The immense treasure of knowledge Kabasura Kudineer (KSK), Immunomodulatory, Thrombolytic, COVID-19, Siddha formulation https://www.ijper.org/article/55/3/801-811 2026-04-13T05:54:35.307177+00:00 Biosynthesized Silver Nanoparticles (AgNPs) from Trapa natans Peel Extract Exhibits Anti-Metastasis and Anti-Biofilm Potentials 2021-08-18 10.5530/ijper.55.3.153 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-801.pdf Background: This study deals with the anti-metastasis and anti-biofilm activities using silver nanoparticles (AgNPs) against human breast cancer cells (MCF-7) via in vitro methods. Different studies have been reported that biofilms formed by Klebsiella pneumoniae, Escherichia coli and Staphylococcus aureus are resistance to most of the recently used antibiotics due to MDR effect. Materials and methods: The characterization of biosynthesized particles was done by UV-vis spectroscopy, FTIR, SEM an Trapa natans, Silver Nanoparticles (AgNPs), Human Breast Cancer Cells (MCF-7), Anti-biofilm, Anti-metastasis, Cytotoxicity https://www.ijper.org/article/55/3/904-915 2026-04-27T09:45:11.798406+00:00 Chemometric Assisted Development and Validation of a Stability-indicating LC Method for Determination of Related Substances in Haloperidol Decanoate Injection 2021-08-18 10.5530/ijper.55.3.165 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-904.pdf Aim: Haloperidol decanoate injection is a phenyl butyl piperadine derivative with antipsychotic, neuroleptic, antiemetic effects and has multiple related substances as process and degradant impurities. Objectives: This study focuses on chemometric assisted liquid chromatographic approach to develop a stability indicating impurity profile of Haloperidol decanoate injection. Methodology: Dual experimental designs (combined mixture I-optimal design and response surface historical data design) were Design of Experiments, Haloperidol decanoate Injection, Stability indicating method, DoE aided chromatographic method development, Artifact optimization https://www.ijper.org/article/55/3/880-887 2026-04-13T05:54:35.307177+00:00 Extraction and Evaluation of Lipid Entrapment Ability of Ocimum basilicum L. Seed Mucilage 2021-08-18 10.5530/ijper.55.3.162 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-880.pdf Background: Overweight, obesity is a serious health problem worldwide and has been becoming an epidemic recently due to the rapid growth of its prevalence. The consequences of obesity are not only its related diseases such as diabetes and cardio vascular disease, but also the effects on global socio-economic. Aim: In this study, we obtained and evaluated characteristics of Ocimum basilicum L. (OB) seed mucilage which fit for developing a weight control product through several characteristics suc High swelling index, Lipid adsorption/absorption, Mucilage characteristics, Ocimum basilicum L., Obesity https://www.ijper.org/article/55/3/748-755 2026-04-13T05:54:35.307177+00:00 Stimulation of Cell Mediated Immune Response by Protein Hydrolysate from Porphyra yezoensis 2021-08-18 10.5530/ijper.55.3.147 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-748.pdf Aim: To investigate the immunomodulatory effects of the protein hydrolysate from Porphyra yezoensis. Objectives: In this study, the in vitro immunomodulatory effects of protein hydrolysate of Porphyra yezoensis was studied by assay of phagocytosis and Nitric oxide production in RAW 264.7 macrophages and DTH (Delayed type hypersensitivity), NBT (Nitroblue tetrazolium) and Neutrophil adhesion assay in mice. Results: Hydrolysate treatment was found to be non-toxic in both in vitro and in vivo model Porphyra yezoensis, Enzymatic hydrolysate, Immunomodulation, Macrophages, Nitrobluetetrazolium, Delayed-type hypersensitivity, Phagocytic index https://www.ijper.org/article/55/3/837-845 2026-04-27T09:41:54.73629+00:00 Antithrombotic Potential of Red Allium cepa and Angelica gigas Nakai 2021-08-18 10.5530/ijper.55.3.157 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-3-837.pdf Introduction: Red Allium cepa and Angelica gigas Nakai is widely used in oriental medicine and also has various physiological activities. The main components of two substances will have potential benefits to blood flow improvement. Objectives: This study evaluated the cell viability and antioxidant effects of Red Allium cepa extract, Angelica gigas Nakai extract and their mixture and observed anticoagulation activity and antiplatelet aggregation activity. Methods: Red Allium cepa was bioconverte Red Allium cepa, Angelica gigas Nakai, Bacillus subtilis KJ-3, Bioconversion, Anti-coagulation https://www.ijper.org/article/55/2s/s595-s604 2026-04-27T09:21:28.539812+00:00 Synthesis and Anticonvulsant Evaluation of 3-(5-(4-substitutedphenyl)-4,5-dihydro-1H-pyrazol-3-ylamino)-2-(2-methylphenyl)quinazolin-4(3H)-one Derivatives 2021-06-20 10.5530/ijper.55.2s.132 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-595.pdf ABSTRACT: Epilepsy arise due to discharge of electric current in CNS and it is Characterized by repeated seizure because of different factors like social, neurological and environmental or it may be due to genetic or non-genetic. A large number of AED’s used to treat epilepsy but all these shows drug resistance and side effects, so research interest continue to find out novel antiepileptic drugs with higher efficiency and less toxicity. A novel series of 3-(5-(4-substitutedphenyl)-4,5-dihydro-1H AED’s, Qinazolin-4-(3H)-one, Anticonvulsant, MES, scPTZ, Neurotoxicity https://www.ijper.org/article/55/2s/s518-s527 2026-04-13T05:54:36.961404+00:00 The Anti-inflammatory Effect of Ethanol Extract Gel of Fig Leaves (Ficus carica Linn.) and Sidr Leaves (Ziziphus mauritiana Linn.) 2021-06-20 10.5530/ijper.55.2s.123 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-518.pdf Inflammation is a form of the body's response to tissue damage with a sign of epidermal thickness, an increase in the number of inflammatory cells and the expression of the COX-2 enzyme. The fig leaves and sidr dry leaves are among the natural ingredients that are used to intervene in inflammation. This study aims to identify the anti-inflammatory effects of ethanol extract of the two natural ingredients formulated in the form of a gel. This study probed 15 groups of research subjects of BALB/c Anti-inflammatory activity, COX-2 enzyme, Inflammatory cells, Fig leaves, Sidr leaves, Gel https://www.ijper.org/article/55/2s/s605-s615 2026-04-13T05:54:36.961404+00:00 Assessment of Toxicity and Drug-Drug Interaction of Combination Therapy Prescribed by Physicians/ Clinicians for Treatment of Diabetes using Experimental Animals 2021-06-20 10.5530/ijper.55.2s.133 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-605.pdf Purpose: The management of diabetes associated with hyperlipidemia is a challenge not only to the physician but also to medical fraternity. Hence most of the physicians prefer to prescribe antihyperglycemic drug along with some lipid lowering agent. The present study is aimed to find out toxicity and drug interaction of combination therapy of hypoglycemic agents (Glimepride, Metformin) withhypolipidemic drugs (Atovastatin + Fenofibrate). Materials and Methods: Young healthy adult Albino Wister r Drug interaction, Diabetes, Toxicity, Combination therapy, Metformin, Atorvastatin https://www.ijper.org/article/55/2s/s353-s363 2026-04-27T09:12:17.097543+00:00 Comparison and Compilation of the Vaccine Approval Process of the United States of America and the European Union: A Road Map for the Emerging and Developing Countries in COVID-19 Crisis 2021-06-20 10.5530/ijper.55.2s.106 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-353.pdf Background: Vaccines are the-omit complex biological preparations that are meant to be used as a treatment or preventive measures against any specific disease condition. Vaccine research and development is a tedious, time and cost consuming process because of stringent quality assessment procedures. Every year approximately 80-85 % of the world’s children receive vaccines; however, regardless of this success rate each year, approximately more than 3 million die from vaccine-preventable diseases Vaccines, Marketing authorization application, USA, EU, COVID-19 https://www.ijper.org/article/55/2s/s385-s395 2026-04-13T05:54:36.961404+00:00 Preparation and Characterization of Chitosan Silicate Conjugate: It’s Role as a Super Disintegrant in Orally Fast Dissolving Films 2021-06-20 10.5530/ijper.55.2s.110 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-385.pdf Aim: The aims of the present research work was to prepare and characterize the chitosan silicate conjugate, conjugate was included in orally fast dissolving films of levo cetirizine di hydrochloride as a super disintegrant and to compare disintegration efficiency with commercial super disintegrant. Materials and Methods: Conjugate was prepared by reacting chitosan with colloidal silicon dioxide. Characterized primarily by determining the charring point, viscosity and wicking property confirmed b Orally fast dissolving films, Chitosan silicate conjugate, Super disintegrant, Disintegration time, in vitro dissolution, in vitro permeation, Reversed phase-high, performance Liquid chromatography https://www.ijper.org/article/55/2s/s448-s456 2026-04-27T09:17:03.232513+00:00 Proof-of-concept for Site-specific Delivery of Mesalamine Nanoparticles for Effective Therapy in Colitis 2021-06-20 10.5530/ijper.55.2s.116 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-448.pdf Background: Mesalamine loaded polymeric nanoparticles were prepared using three different polymers namely, Eudragit RS100, PLGA (50:50), or Eudragit RLPO, with an aim of targeted delivery to the inflamed colon. Materials and Methods: Nanoparticles were prepared by modified emulsification solvent evaporation and characterized for various physicochemical characteristics viz., size, size distribution, mesalamine entrapment, and in-vitro release. Results: Amongst the various formulations prepared, f Nanoparticles, Mesalamine, Inflammatory Bowel Disease, Eudragit RS100, PLGA, Eudragit RLPO https://www.ijper.org/article/55/2s/s563-s571 2026-04-13T05:54:36.961404+00:00 Protective Effect of Boerhavia diffusa in Attenuating Pro-inflammatory Cytokines and Inhibition of Activated NF-κB-TNF-α-Nrf2 in Freund’s Adjuvant-induced Rheumatoid Arthritis 2021-06-20 10.5530/ijper.55.2s.128 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-563.pdf Background: Boerhavia diffusa is widely used in Asian and African countries in the treatment of inflammatory disorders in adjunct with other herbal formulations. The current research work was devised with an aim to examine the protective effect of hydroalcoholic root extract of Boerhavia diffusa in rheumatoid arthritis. Materials and Methods: Hydroalcoholic extract of plant at varying doses and reference drug (indomethacin 3mg/kg), were administered daily for 21 days. The parameters such as join Boerhavia diffusa, Rheumatoid Arthritis, NF-κB pathway, Angiogenesis, Inflamation https://www.ijper.org/article/55/2s/s428-s440 2026-04-13T05:54:36.961404+00:00 Curcumin Loaded Eudragit S100/PLGA Nanoparticles in Treatment of Colon Cancer: Formulation, Optimization, and in-vitro Cytotoxicity Study 2021-06-20 10.5530/ijper.55.2s.114 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-428.pdf Introduction: Polymeric nanoparticles provide a promising strategy for site-specific delivery of dietary phytochemicals in the treatment of colon cancer. Curcumin (CU) is a dietary phytochemical with well-proven anti-cancer activity in colon cancer. However, its clinical application is confined because of its hydrophobicity, lack of selectivity towards tumor tissues, and poor bioavailability. Objectives: The main objective of the study was to enhance the selectivity and cytotoxicity of poorly wa Colon cancer, Curcumin, Nanoparticles, Cytotoxicity, Nanoprecipitation, Box-Behnken https://www.ijper.org/article/55/2s/s468-s478 2026-04-13T05:54:36.961404+00:00 Embelin and Levodopa Combination Therapy Mitigates Parkinson's Disease Complications in Mice 2021-06-20 10.5530/ijper.55.2s.118 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-468.pdf Purpose: The present work evaluated the neuroprotective potential of embelin either alone and in combination with Levodopa in rotenone induced PD (Parkinson’s disease) model mice. Methods: Swiss albino male adult mice were randomly divided into 7 groups. Group-1 (Control) received 2mL/kg olive oil by oral route (p.o.), Groups from 2 to 7 were induced with 2.5mg/kg rotenone by intraperitoneal route (i.p.), levodopa was administered to Group-3. Group-4 and Group-5 were given 20mg/kg and 40mg/kg em Parkinson’s disease, Swiss albino mice, Rotenone, Embelin, Levodopa https://www.ijper.org/article/55/2s/414-s427 2026-04-13T05:54:36.961404+00:00 Development of Colon Targeting Tablet of a JAK Inhibitor to Combat Chronic Ulcerative Colitis: A Novel Approach for Local Drug Delivery 2021-06-20 10.5530/ijper.55.2s.113 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-414.pdf Background: Tofacitinib, a pan-Janus kinase (JAK) inhibitor, initially used for the treatment of rheumatoid arthritis, was later found to have robust efficacy in Phase 2 and Phase 3 ulcerative colitis clinical trials. It had been approved by FDA for its use in the treatment of moderate to severe ulcerative colitis, in 2018. Objectives: The main objective of the present work was to develop a new colonic drug delivery system for tofacitinib using combined approaches of formulating an extended rele Colon targeted matrix tablet, Controlled release, Lag period, Ulcerative colitis, Tofacitinib, JAK inhibitor, Immunosuppressant https://www.ijper.org/article/55/2s/s528-s534 2026-04-13T05:54:36.961404+00:00 Neuroprotective Effect of Petroleum Ether, Methanolic and Aqueous Extracts of Fruits of Benincasa hispida on Lipofuscinogenesis and Fluorescence Product in Brain of D-galactose Induced Aging Accelerated Mice 2021-06-20 10.5530/ijper.55.2s.124 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-528.pdf Background: Aging is one of the major factors of development of neurodegenerative disorder and also involved in gradual learning and memory loss. In recent years discovery of antiaging drugs is one of the important topic of research. Many plant drugs proved to be reliable treatment for aging associated changes. Aim: The present investigation was aimed at determining the neuroprotective effect of petroleum ether (BHP), Methanolic (BHM) and aqueous extract (BHA) obtained from Benincasa hispida by Neuroprotection, Aging accelerattion, Fluorescence product, Lipid peroxidation, Lipofuscin granules, Benincasa hispida https://www.ijper.org/article/55/2s/s345-s352 2026-04-13T05:54:36.961404+00:00 Medicinal and Nutritional Wonders of Miracle Moringa oleifera Lam.: Another Look 2021-06-20 10.5530/ijper.55.2s.105 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-345.pdf Background: Frequently described by Bogar and other greatest sithars, Moringa oleifera Lam (Moringa was derived from the Tamil word murungai)), is popular for its medicinal and nutritional values and benefits. Rich with many nutrients, it is useful to prevent and/ or cure diverse kinds of ailments. Methods: Available literature in Google, and other search engines, and gene interaction details from Gencards.org, etc. were used. Results: The various diverse biological and pharmacological activitie Moringa oleifera, Phytocompounds, Proteomic studies, Heat shock proteins, Phytochemicals, Bioactive compounds https://www.ijper.org/article/55/2s/s373-s378 2026-04-27T09:14:49.595487+00:00 Transformation of Teachers to Mentors: Prerequisite of Time is to Excel Innovative Practices in Academics 2021-06-20 10.5530/ijper.55.2s.108 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-373.pdf The perception of Mentoring is definitely not new; indeed, it comes from a character named “Mentor” in Homer’s Odyssey. He was a trusted mentor to Odysseus’ son. The recent studies and Figures have given rise to prosperous mentoring. Mentoring focuses on the individual’s needs, his role is to inculcate and instill skills needed for future roles. Mentors have often had a successful career path, beginning in a similar place as the mentee. They offer assistance through sharing their own experiences Mentor, Teacher, Skills, Teaching pedagogy, Innovation, Knowledge https://www.ijper.org/article/55/2s/s510-s517 2026-04-27T09:18:43.80553+00:00 Green-synthesis of Silver Nanoparticles by Hygrophila auriculata Extract: Innovative Technique and Comprehensive Evaluation 2021-06-20 10.5530/ijper.55.2s.122 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-510.pdf Background: Metal nanoparticles are of great scientific interest as they bridge the gap between the bulk and atomic structures. A number of methods of synthesizing nanoparticles have been developed and can be grouped into top-down (physical), bottom-up (chemical) and biological methods. Physical methods are expensive due to continuous consumption of energy to maintain the high pressure and temperature employed in nanoparticle synthesis and requires highly sophisticated equipment. In the chemical Green synthesis, Silver nanoparticles, Hygrophila auriculata, Characterization, Surface Plasmon resonance https://www.ijper.org/article/55/2s/s552-s562 2026-04-13T05:54:36.961404+00:00 Methanolic Extract of Angelica glauca Edgew Root and Stem: A Possible Component of Herbal Medicines against Respiratory Infections 2021-06-20 10.5530/ijper.55.2s.127 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-552.pdf Plants are identified to produce a variety of compounds to protect themselves against a diversity of pathogens. This study assessed the antibacterial, antioxidant potential and phytochemical screening of medicinal plant Angelica glauca (Choru) root and stem extracts against respiratory tract pathogens i.e., Staphylococcus aureus MTCC 1144, Streptococcus pneumoniae MTCC 655, Streptococcus pyogenes MTCC 442, Pseudomonas aeruginosa MTCC 2474 and Klebsiella pneumoniae MTCC 4030. The plant material w Angelica glauca, Antibacterial, Two-fold serial dilution, Natural antioxidant, Phytomedicine, Respiratory tract pathogens, DPPH, COVID-19 https://www.ijper.org/article/55/2s/s340-s344 2026-04-27T09:10:32.847584+00:00 Prescription: A Situation Analysis in Indian Health Care System 2021-06-20 10.5530/ijper.55.2s.104 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-340.pdf A prescription is the vital written communication from physician to patient, which consist of instruction to pharmacist on dispensing of drug regimen. Prescription writing is a critical task that suggests prescriber’s responsibility towards the safe prescribing and monitoring to provide clinical care to the patient thus carries legal implications. Physicians oftentimes scribble down and take shortcuts in writing down drug orders that are not legible. Illegible writing leads to medication errors. Prescription writing, Medication errors, Record linkage, Computerised, prescription, Personal identification number https://www.ijper.org/article/55/2s/s572-s579 2026-04-13T05:54:36.961404+00:00 Development and Validation of Ultraviolet Spectroscopic Method for Estimation of Methoxsalen in Bulk Using Methanol and Phosphate Buffer (pH 7.4) 2021-06-20 10.5530/ijper.55.2s.129 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-572.pdf Background: Psoriasis is an inflammatory condition of a body wherein erythematous, sharply demarcated papules and round-shaped plaques appear onto skin due to the hyperproliferation of epidermis. Psoralens are the class of furanocoumarins that are effectively used in the treatment of psoriasis and vitiligo in conjunction with exposure to a dose of ultraviolet radiation. It is crucial to develop and validate the suitable analytical method for its quantitative estimation. The present work aims to Methoxsalen, UV- Visible Spectroscopy, Methanol, Phosphate Buffer Saline (pH 7.4), Validation https://www.ijper.org/article/55/2s/s364-s372 2026-04-13T05:54:36.961404+00:00 Impact of International Accreditation in Pharmacy Education: Pharmacy School Students’ Perspective 2021-06-20 10.5530/ijper.55.2s.107 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-364.pdf Background: The accreditation of undergraduate Pharmacy Schools is an important quality assurance process. In spite of the widespread adoption of international accreditation processes and an increasing attention on accreditation as a mechanism to ensure minimum standards are met, there is little evidence to support their effectiveness. Objectives: To assess the School of Pharmacy students’ and new graduates’ views on the impact of international certification on their education and career and whe Accreditation, International certification, Pharmaceutical education, Students, Pharmacy, Learning environment https://www.ijper.org/article/55/2s/s379-s384 2026-04-13T05:54:36.961404+00:00 Role of Learning Approach in Determining Learning Outcome During Active and Passive Learning Sessions in Pharmacology 2021-06-20 10.5530/ijper.55.2s.109 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-379.pdf Objectives: The objective of the study is to estimate the difference in knowledge gain between the students of varied learning approaches during didactic lectures and concept mapping lectures. Materials and Methods: The study participants included 118 secondyear medical undergraduate students. The learning approaches of the participants were assessed using the ASSIST questionnaire on a 5-point Likert-type scale. Two lectures in pharmacology subject were taken using the concept mapping technique Learning approach, Deep learners, Surface learners, Strategic learners, Learning outcome https://www.ijper.org/article/55/2s/s501-s509 2026-04-13T05:54:36.961404+00:00 Evaluation of Antioxidant, Immunomodulatory and Anticancer Properties of Methanolic Extract of Neolamarckia cadamba Linn. Fruits 2021-06-20 10.5530/ijper.55.2s.121 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-501.pdf Background: The immune system plays an important role in various diseased conditions. Patients with compromised immune function are at increased risk of exposure. Thus, the evaluation of immunomodulatory activity of plant extracts may be helpful for prophylactic treatment approach. Objectives: The aim of present study is to evaluate the effect of methanolic extract of Neolamarckia cadamba Linn. fruits for antioxidant, immunomodulatory and anticancer properties using in-vitro and in-vitro models. Neolamarckia cadamba, Immunomodulatory, Antioxidative, Anticancer, Cytokines, Neutrophil adhesion https://www.ijper.org/article/55/2s/s396-s404 2026-04-13T05:54:36.961404+00:00 Datura stramonium Leaves Mucilage Aided Buccoadhesive Films of Aceclofenac using 32 Factorial Design with Design-Expert Software 2021-06-20 10.5530/ijper.55.2s.111 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-396.pdf Aim and Objectives: The main motto of this work was to search the additive effect of Datura stramonium leaves mucilage in the making of buccoadhesive film by taking Aceclofenac as a model drug. Materials and Methods: Nine formulations of buccal films were made using Carbopol 934 P and varying proportions of Ethyl Cellulose and D. stramonium leaves mucilage. The films were judged for compatibility studies and physical constraints including Aceclofenac content and discharge. Results: Among the fil Aceclofenac, Mucilage, Factorial design, Buccal Film, Bio adhesive strength https://www.ijper.org/article/55/2s/s580-s588 2026-04-27T09:20:44.113309+00:00 Synchronized Quantitative Assessment of Corticosteroid and Bronchodilator in Rotacaps by HPTLC using Fractional Factorial Design 2021-06-20 10.5530/ijper.55.2s.130 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-580.pdf Background: A validated high performance planar chromatographic analysis for a combination medication of corticosteroids mometasone furoate and bronchodilators formoterol fumarate available as Evocort®: inhaler in market was developed. It is used for treating asthma, a reversible obstructive airways disease. Materials and Methods: The HPTLC chromatographic condition was optimised using aluminium sheets formerly coated with silica gel 60F254 as stationary phase and toluene: methyl alcohol: methan Analytical method development, Validation, HPTLC, Mometasone furoate, Formoterol fumarate, DoE https://www.ijper.org/article/55/2s/s616-s622 2026-04-13T05:54:36.961404+00:00 A Recent Regulatory Update on Consequences of Data Integrity Issues and its Management in Pharmaceutical Scenario 2021-06-20 10.5530/ijper.55.2s.134 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-616.pdf Purpose: Pharmaceutical industry ensures that data entered for various steps of drug development is accurate, which gives us confidence that the drugs produced by the industry are within specified parameters. Data integrity indicates sustaining and assuring the accuracy and reliability of data throughout the life cycle of the product.Over the years, numerous leading regulatory authorities have communicated their expectations in the form of regulations and guidance documents from the US FDA, MHRA Data integrity, Warning letters, Audit, Inspection, Quality system, Regulatory https://www.ijper.org/article/55/2s/s441-s447 2026-04-13T05:54:36.961404+00:00 Polyacrylamide Grafted Gum Acacia (GA-g-PAM) Graft Copolymer as Efficient Polymeric Scaffold 2021-06-20 10.5530/ijper.55.2s.115 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-441.pdf Background: Natural polysaccharides are mostly not stable in their original form but their biodegradable properties can be beneficial for use as polymeric scaffolds for tissue engineering. Microwave irradiation assisted grafting synthesis being an easy and quick method enhances stability of these natural polysaccharides. Materials and Methods: Initially the optimization of the redox initiator ammonium per sulfate (APS) along with the monomer concentration acrylamide (AM) was done by % grafting e Graft copolymer, Microwave assisted synthesis, Tissue engineered scaffold, Gum acacia, Acrylamide https://www.ijper.org/article/55/2s/s479-s491 2026-04-13T05:54:36.961404+00:00 Effect of β-sitosterol on Insulin Receptor, Glucose Transporter 4 Protein Expression and Glucose Oxidation in the Gastrocnemius Muscle of High Fat Diet Induced Type -2 Diabetic Experimental Rats 2021-06-20 10.5530/ijper.55.2s.119 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-479.pdf Background: The newly available medications are ineffective because of their unintended side effects in the treatment of type 2 diabetes. Hence, search drugs, from plant sources. β-sitosterol is plant sterols with structurally almost like that of cholesterol. It is widely present in various medicinal plants. Although the sterol it was shown to possess antihyperglycemic activity, the mechanism of action of the plant sterol on a high-fat diet (HFD)-induced insulin resistance in gastrocnemius muscl β-sitosterol, IR, GLUT4, Glucose uptake and oxidation, Gastrocnemius muscle, High fat diet and sucrose, Type-2 diabetes, Insulin Signaling, Insulin resistance https://www.ijper.org/article/55/2s/s535-s543 2026-04-13T05:54:36.961404+00:00 Scientific Evaluation of Anti-obesity Potential of Methanolic Leaves extract of Ocimum sanctum (Linn.) in Monosodium Glutamate - High Fat Diet Induced Obese Mice 2021-06-20 10.5530/ijper.55.2s.125 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-535.pdf Background: obesity is the deposition of body fat mass from the imbalance between calorie intake and vitality consumption. The metabolic syndrome brings the risk of health hazards like type-2diabetes, stroke and cardiovascular disease. Objectives: To evaluate the anti-obesity activity of methanolic extract of Ocimum sanctum leaves in monosodium glutamate (MSG) and high-fat diet (HFD) induced mice. Materials and Methods: To study the anti-obesity activity, free radical scavenging activity by DPPH Ocimum sanctum, Anti-obesity, MSG- HFD mice model, Methanolic extract, Body weight https://www.ijper.org/article/55/2s/s544-s551 2026-04-27T09:19:36.890642+00:00 Endophytic Fungi, Drechslera spicifera, Mediated Synthesis of Biogenic Silver Nanoparticles 2021-06-20 10.5530/ijper.55.2s.126 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-544.pdf Aim: In present communication, endophytic fungi Drechslera spicifera is isolated from leaves of Cardiospermum halicacabum and used as a reducing agent for silver nanoparticles (AgNPs) synthesis. Materials and Methods: Synthesized AgNPs were characterised using UV-vis spectroscopy, FTIR, scanning-electron microscopy (SEM) and particle size analysis. Total phenolic, flavonoid content and antioxidant potential of endophytic fungi (culture and aqueous extract), host plant Cardiospermum halicacabum ( Cardiospermum halicacabum, Drechslera spicifera, Endophytic fungi, Silver nanoparticle, Antioxidant https://www.ijper.org/article/55/2s/s457-s467 2026-04-13T05:54:36.961404+00:00 Protective Role of Caffeic Acid in Cognitive Dysfunction and Oxidative Stress Induced by Colchicine in Rats 2021-06-20 10.5530/ijper.55.2s.117 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-457.pdf Purpose: Alzheimer’s is a disease affecting mostly the Older population leading to the deterioration of cognitive capabilities. The protective effect of Caffeic acid in Colchicine-induced dementia was evaluated in the current study. Materials and Methods: Colchicine was administered intracerebroventricularly (ICV) to the lateral ventricle of the brain (at the coordinates 0.8 mm posterior to bregma, 1.8 mm lateral to the sagittal suture, 3.6 mm below the cortical surface) using robotic stereotaxi Colchicine, Caffeic acid, Alzheimer’s disease, Antioxidant, Neuroprotection, Cholinesterase https://www.ijper.org/article/55/2s/s405-s413 2026-04-13T05:54:36.961404+00:00 Solubility Enhancement of Embelin by Complexation with Beta Cyclodextrin 2021-06-20 10.5530/ijper.55.2s.112 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-405.pdf Introduction: Embelin, a phytoconstituent obtained from Embelia ribes of the Myrsinaceae family, has anti-cancer, anti-inflammatory, anti-bacterial, anti-fertility, analgesic, antidiabetic, anti-depressant and wound healing activities. It is hydrophobic in nature leading to low bioavailability. Aim: The present study aims to improve the water solubility and rate of dissolution of Embelin by complexation with β-cyclodextrin. Methods: Inclusion complexes were prepared by physical mixture, kneading Embelin, β-cyclodextrin, Inclusion complexes, Solubility, Co-precipitation, method https://www.ijper.org/article/55/2s/s327-s339 2026-04-13T05:54:36.961404+00:00 Solid Dispersion as a Technical Solution to Boost the Dissolution Rate and Bioavailability of Poorly Water-Soluble Drugs 2021-06-20 10.5530/ijper.55.2s.103 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-327.pdf Solid dispersion (SD) is one of the oldest and widely utilized techniques to improve the solubility of slowly dissolving drugs. A variety of pharmaceutically compatible additives using different emerging technology is used for preparing SDs. Multiple approaches were designed to prepare SDs by such as kneading, co-milling, fusion, solvent evaporation and various solvent-associated methods. The selection of appropriate preparation method and carrier is vital for producing a homogenous product affe Solid dispersion, Solvent evaporation, Fusion, Co-milling, Kneading, Electrospinning, KinetiSol® https://www.ijper.org/article/55/2s/s589-s594 2026-04-13T05:54:36.961404+00:00 Novel Analytical Method Development, Validation and Stability Study of Anticancer Drug Erlotinib in Tablet Dosage Form by RP-UFLC 2021-06-20 10.5530/ijper.55.2s.131 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-589.pdf Present work is aimed to develop a novel, simple and accurate reverse phase-ultrafast liquid chromatographic (RP-UFLC) method for erlotinib (ELB) in tablet dosage form. The chromatogram was achieved by using Eclipse plus C18 column with methanol and water along with triethylamine (TEA 0.1%) as mobile phase (50:50 v/v) at a flow rate of 1 ml/min. The tablet dosage form was assayed, validated and subjected to degradation studies. The standard ELB possessed a retention time of 5.51 min and the deve Erlotinib, Accuracy, Precision, Robustness, Degradation study https://www.ijper.org/article/55/2s/s492-s500 2026-04-27T09:18:16.798346+00:00 An Agro-ecological Zoning Model Highlighting Potential Growing Areas for Medicinal Plants in Punjab 2021-06-20 10.5530/ijper.55.2s.120 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2s-492.pdf Background: The Ministry of AYUSH, Government of India has decided to emerge cultivation of medicinal plants as an attractive farming option due to a sharp increase in demand for medicinal plants. Punjab produces approximately twenty and nine percent of India’s wheat and rice, respectively. At present, less than 1% of the state’s land is under Medicinal and Aromatic Plant (MAP) cultivation. Agro-ecological zoning for potential medicinal plants is one of the major constraints faced by the farmers Agro-climatic zoning, Asparagus racemosus Willd., Geographical Information System, Rauvolfia serpentina (L.) Benth. ex Kurz. https://www.ijper.org/article/55/2/354-362 2026-04-13T05:54:38.118918+00:00 Formulation and Characterization of Chitosan Microparticulate System Using Central Composite Design for the Drug: Lafutidine 2021-05-15 10.5530/ijper.55.2.73 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-354.pdf Aim: To formulate a Micro particulate system using central composite design to remain in the stomach for prolonged time and used for Gastroretentive drug delivery. Materials and Methods: Gastroretentive Microspheres were prepared by Emulsion Solvent Evaporation. Micro particulate system were evaluated for micro meritic study, percentage yield, drug entrapment efficiency, in-vitro buoyancy, surface morphology, in-vitro drug release, in-vivo floating study and stability studies. Results: The micro Lafutidine, Chitosan, Central composite design, In vitro drug release, Microparticulate system https://www.ijper.org/article/55/2/455-462 2026-04-13T05:54:38.118918+00:00 Exploring the Rational Designing of Protein Ligand Binding for Mouth Ulcer from Methanolic Extract of Olax psittacorum 2021-05-15 10.5530/ijper.55.2.83 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-455.pdf Background: Olax psittacorum, a flowering plant grown in open forests, is consumed by the locals as dietary sources. Aim: This study was designed to check the phytochemical screening, antioxidant activity, antimicrobial studies and Chorioallantoic Membrane (CAM) study in the methanolic extract of Olax psittacorum. Further, in silico docking study was performed on the basis of GC-MS report of the methanolic extract. Methods: Antimicrobial activity was tested against five bacterial strains Escheri Protein-ligand binding, Toxicity, Antioxidant study, Activity study, Methanolic, extract https://www.ijper.org/article/55/2/428-435 2026-04-13T05:54:38.118918+00:00 Encapsulation of Freeze-dried Propolis Powder: Study of in vitro Disintegration and Dissolution 2021-05-15 10.5530/ijper.55.2.80 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-428.pdf Propolis is a resinous material collected by bees from various plant sources. Propolis has been used since ancient times for medicinal purposes. In this study, the propolis extracts were dried using a freeze-drying technique to preserve its medicinal properties. The effect of different freezing temperatures on the yield and propolis powder flow ability characteristics was evaluated. The potential of propolis powder to be encapsulated in hard gelatin capsules and hard hydroxypropyl methylcellulos Propolis, Trigona thoracica, Freeze-drying, Capsule, Disintegration, Dissolution https://www.ijper.org/article/55/2/621-628 2026-04-13T05:54:38.118918+00:00 Results of Development and Application of an Objective Structured Clinical Examination: A Pioneering Experience in Pharmaceutical Care 2021-05-15 10.5530/ijper.55.2.102 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-621.pdf Objectives: Objective Structured Clinical Examination (OSCE) is a tool to assess skills and competencies and it can be relevant in Pharmacy studies and more specifically in Pharmaceutical Care (PC) to develop more practical and useful skills in the working life of a healthcare professional. Design and Methods: A prospective study was performed by students of the subject of PC in the Bachelor of Pharmacy and by students from the Master in PC, at the end of their classes. Five stations with standa Competencies, Education, Objective Structured Clinical Evaluation, Pharmaceutical care, Pharmacy services https://www.ijper.org/article/55/2/556-565 2026-04-13T05:54:38.118918+00:00 Lyophilized Fruit Juice of Citrus sinensis Triggers Mitochondria-mediated Apoptosis via Downregulation of PI3K/AKT in MCF-7 Cell Line 2021-05-15 10.5530/ijper.55.2.94 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-556.pdf Background: Breast cancer is prevalent cancer among women and a major cause of death worldwide due to various genetic and environmental factors. Citrus sinensis is widely taken fruit juice in most countries that are believed to reduce breast cancer risk. However, the mechanism through which it acts remains unclear. Our objective was to explore the mechanism through which Citrus sinensis acts as a cytotoxic agent. Materials and Methods: FT-IR and GC-MS analyses of lyophilzed orange juice (LOJ) we Lyophilized orange juice, Molecular docking, Apoptosis, MCF-7 cell line, PI3K/AKT/mTOR https://www.ijper.org/article/55/2/517-526 2026-04-13T05:54:38.118918+00:00 Therapeutic Phytochemical Actives for Potential Control of SARS-CoV-2 2021-05-15 10.5530/ijper.55.2.90 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-517.pdf Background: Drug development strategies for treating COVID-19 focus on actives that either physically block angiotensin-converting enzyme-2 (ACE-2) receptors (viral entry point), or those, which inactivate viral proteases like 3CLpro or RdRp, inside the infected host cells. Objectives: The objective of the present study is to virtually screen phytochemicals for both these purposes. Methods: Molecular docking, molecular dynamic simulation (MDS) and multiple sequence alignment were employed. Resul COVID-19, SARS-CoV-2, Angiotensin Converting Enzyme-2, 3CLpro, RdRp https://www.ijper.org/article/55/2/304-318 2026-04-13T05:54:38.118918+00:00 Artificial Intelligence in Pharmacy 2021-05-15 10.5530/ijper.55.2.68 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-304.pdf Artificial Intelligence (AI) focuses in producing intelligent modelling, which helps in imagining knowledge, cracking problems and decision making. Recently, AI plays an important role in various fields of pharmacy like drug discovery, drug delivery formulation development, polypharmacology, hospital pharmacy, etc. In drug discovery and drug delivery formulation development, various Artificial Neural Networks (ANNs) like Deep Neural Networks (DNNs) or Recurrent Neural Networks (RNNs) are being e Artificial intelligence, Artificial neural network, Drug discovery, Drug delivery, research, Hospital pharmacy https://www.ijper.org/article/55/2/407-417 2026-04-13T05:54:38.118918+00:00 Design and in-vitro Evaluation of Float-adhesive Famotidine Microspheres by using Natural Polymers for Gastroretentive Properties 2021-05-15 10.5530/ijper.55.2.78 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-407.pdf Objectives: In the present investigation a novel oral drug delivery system was developed by combining two different techniques floating and mucoadhesive system so called floatadhesive, in order to obtain a controlled system that could remain in the stomach for prolonged period and release the drug in a controlled manner. Materials and Methods: Microspheres containing Famotidine were prepared by ionic gelation method using Mimosa pudica seed mucilage as a natural mucoadhesive polymer. Sodium algi Natural polymers, Mimosa pudica mucilage, Chitosan, Floating, Mucoadhesive, Float-adhesive, Ionic gelation https://www.ijper.org/article/55/2/527-543 2026-04-13T05:54:38.118918+00:00 Adjunction of the Lipase Inhibitor Orlistat Improves Grape Seed Extract Neuroprotection against Brain Ischemia/Reperfusion Injury in Rats 2021-05-15 10.5530/ijper.55.2.91 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-527.pdf Aim: Stroke is a public health concern for which there is currently no prophylaxis. In this study, we assessed the protective effect of Grape Seed Extract (GSE) and Orlistat (ORL) against brain ischemia/reperfusion (I/R) injury. Methods: Adult male Wistar rats were treated either with GSE (2.5 g/kg), ORL (4 mg/kg) or both drugs for one week and ischemia performed during 30 min by a bilateral common carotid artery occlusion (BCCAO), followed by 60 min reperfusion. Rats were then sacrificed, their Brain I/R, GSE, Orlistat, Neuroprotection, Energy failure https://www.ijper.org/article/55/2/346-353 2026-04-13T05:54:38.118918+00:00 Targeted Drug Delivery System: Advantages, Carriers and Strategies 2021-05-15 10.5530/ijper.55.2.72 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-346.pdf Drug targeting is a new drug delivery system that aims to deliver the drug to the target site of action or site of absorption without releasing the drug at any other non-target site. The delivery system is designed to retain the intact drug without any modification until reaching and releasing at the target site. The targeted drug delivery systems have several advantages over conventional ones as improvement of pharmaceutical activity, low side effects and reduction of the administered dose. The Drug targeting, Drug delivery system, Pharmacological action, Chemotherapeutic agents, Gold nanoparticles https://www.ijper.org/article/55/2/581-589 2026-04-13T05:54:38.118918+00:00 Designing of Thiazolidin-4-one Pharmacophore using QSAR Studies for Anti-HIV Activity 2021-05-15 10.5530/ijper.55.2.97 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-581.pdf Background and Aim: In an effort of drug development in the area of HIV, present work deals with development of 2D and 3D QSAR of thiazolidinone derivatives against HIV-RT activity as a powerful method for elucidation the relationships between structure and activity. Materials and Methods: 2D QSAR and 3D QSAR were performed using MLR and SA kNN method respectively. Models which had higher predictability were generated as indicated from their statistical parameters. Results and Discussion: Best m Non-nucleoside Reverse Transcriptase, Human Immunodeficiency Virus-1, QSAR, Thiazolidin-4-one, Combilib https://www.ijper.org/article/55/2/363-373 2026-04-13T05:54:38.118918+00:00 Synthesis, Characterization and Pharmacological Evaluation of Biphenyl Based 4-Thiazolidinones 2021-05-15 10.5530/ijper.55.2.74 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-363.pdf Background: Biphenyl based 4-thiazolidinones are found to possess a wide range of activities resulting in their synthesis. Methods: Eight molecules (VIIa-VIIh) were profoundly synthesized using four step procedures. These 4-thiazolidinone derivatives were characterized by elemental analysis (CHN) and spectral (IR and 1H NMR) analysis. All the compounds were evaluated for their in vitro antimicrobial activity against one Gram negative strain (Escherichia coli) and two Gram positive strains (Bacil Biphenyl based 4-thiazolidinone, Antimicrobial, Antibacterial, Antifungal, Schiff's bases https://www.ijper.org/article/55/2/607-613 2026-04-13T05:54:38.118918+00:00 Stability Indicating Assay Method Development and Validation for Simultaneous Estimation of Ofloxacin and Ornidazole by RP-HPLC in Bulk: An Application to Tablet Formulation and Dissolution Studies 2021-05-15 10.5530/ijper.55.2.100 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-607.pdf Aim: The present article focuses on development of sensitive, simple, precise, accurate and inexpensive stability indicating assay method for the simultaneous estimation of Ofloxacin and Ornidazole in bulk was established using RP-HPLC. Materials and Methods: The separation was done with C18 Phenomenex Hyperclone BDS column (250×4.6mm, 5μ) at a temperature of 25°C using a mobile phase of acetonitrile: pH 5.8 ammonium acetate buffer of ratio 25:75 with a flow rate of 1ml/min. The detection was do Ofloxacin, Ornidazole, Stability indicating method, HPLC, Dissolution https://www.ijper.org/article/55/2/544-549 2026-04-13T05:54:38.118918+00:00 Investigation of the Effects of Calcium Fructoborate on Testicular Structure in Rats within the Framework of Biochemical Parameters, Testosterone Hormone and DNA Damage in Cadmium Chloride Induced Toxicity 2021-05-15 10.5530/ijper.55.2.92 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-544.pdf Background: The present study aims to investigate the effects of calcium fructoborate on testicular DNA damage and testicular tissue biochemical markers and serum testosterone levels after cadmium chloride administration. Materials and Methods: 28 Wistar albino rats (200-220 g) in the study were divided into 4 groups with an equal number. These groups are; Control group (No chemicals applied), calcium fructoborate (100 mg) group, Cadmium chloride (200 mg/L) + calcium fructoborate (100 mg), Cadmi Cadmium chloride, Calcium fructoborate, Rat, 8-OHdG, Testosterone https://www.ijper.org/article/55/2/566-573 2026-04-13T05:54:38.118918+00:00 Antiproliferative and Apoptotic Induction of Allicin in Human Lung Cancer Cell Lines 2021-05-15 10.5530/ijper.55.2.95 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-566.pdf Background: The study relied on exploring the anticancer effects of allicin and the experimental parameters to scientifically prove its potential as a natural anticancer agent, condiment and dietary supplement present in several Allium plant varieties. Materials and Methods: In the current investigation, the efficiency of allicin was checked for its antiproliferative and apoptosis-prompting potential in the human lung cancer cell lines A549. Results: The inhibitory concentration (IC50) of allici Allicin, Cytotoxicity, Lung cancer, Apoptosis, Protein expression https://www.ijper.org/article/55/2/319-329 2026-04-13T05:54:38.118918+00:00 Possible Insights into the Use of Silver Nanoparticles in Targeting SARS-CoV-2 (COVID-19) 2021-05-15 10.5530/ijper.55.2.69 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-319.pdf Aim: The aims of this review are to assess the anti-viral and targeting strategies using nano materials and the possibility of using Silver nanoparticles for combating the SARS-CoV-2. Background: The novel Coronavirus (SARS-CoV-2) has become a global pandemic and has spread rapidly worldwide. Researchers have successfully identified the molecular structure of the novel coronavirus however significant success has not yet been observed with the therapies currently in clinical trials and exhaustive SARS-CoV-2, Pandemic, Immunomodulation, Silver nanoparticles, In-vitro https://www.ijper.org/article/55/2/418-427 2026-04-13T05:54:38.118918+00:00 Statistical Optimization Amalgamated Approach on Formulation Development of Nano Lipid Carrier Loaded Hydrophilic Gel of Fluticasone Propionate 2021-05-15 10.5530/ijper.55.2.79 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-418.pdf Introduction: Formulation of a nano lipid carrier loaded hydrophilic gel of a corticosteroid, fluticasone propionate (FP) was investigated systemically with response surface model (RSM) for promising dermal delivery of the drug. Objectives: To achieve a better penetration of the drug and to overcome the generally associated adverse reactions of corticosteroids, the present study, explored the formulation and evaluation of nano lipid carriers (NLCs) of FP in a hydrophilic gel base. Methods: A cen Fluticasone propionate, Niosome, Central composite design, Gel, Ex-vivo, permeation https://www.ijper.org/article/55/2/629-637 2026-04-13T05:54:38.118918+00:00 Pharmaceutical Camel Products; Marketing Strategies for Successful International Penetration 2021-05-15 10.5530/ijper.55.2.67 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-629.pdf Background: This research aimed at how Saudi Arabia can be the global giant producer of pharmaceutical camel products using strategies for successful international penetration. In certain areas of Asia and Africa camel milk, urine, skin, and intestines are used as medicine from ancient days. Camel milk is the source of Vitamin C, B1, and B2. Heparin and gelatin are also extracted from the intestine and skin of the camel, respectively. While it is widely acknowledged that pharmaceutical companies Pharmaceutical companies, Camel Products, International strategies, Globalization, Public awareness, General text https://www.ijper.org/article/55/2/436-444 2026-04-13T05:54:38.118918+00:00 Determination of Haematological Effects of Extracts of Reseda sphenocleoides Leaves in Albino Rats Infected with Entamoeba histolytica 2021-05-15 10.5530/ijper.55.2.81 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-436.pdf Objectives: This research was designed to examine improvements in some heamatological parameters of Entamoeba histolytica-infected rats treated with extracts of Reseda sphenocleoides leaves. Methods: Twenty rats weighing between 200-220 g were divided into 4 groups (Each per group containing 5 rats). Fifteen rats were infected by oral administration (17×103 cell/ml) of E. histolytica obtained from the stool. Infected rats were classified in differentiated three groups A, B, C. In addition, the n Reseda sphenocleoides, Extract, Entamoeba histolytica, Haematological, Albino rats https://www.ijper.org/article/55/2/574-580 2026-04-27T09:02:51.316784+00:00 Synthesis, Antidiabetic Evaluation and Bioisosteric Modification of Quinoline Incorporated 2-pyrazoline Derivatives 2021-05-15 10.5530/ijper.55.2.96 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-574.pdf Background: Diabetes mellitus is a pervasive illness worldwide with many progressively increasing complications day by day. The quinoline nucleus is important heterocyclic moiety with different biological activities. Due to their pivotal role in different biological processes they are well explored as therapeutic agents and some of them have exhibited antihyperglycemic activity. Different substituted pyrazoles have been accounted for their in vivo antidiabetic activity, but we concentrated to su Quinoline, Oxo linked, Amino linked, Chalcones, Pyrazoline, Antidiabetic, activity https://www.ijper.org/article/55/2/330-335 2026-04-13T05:54:38.118918+00:00 An Overview of Dual Targeting Nanostructured Lipid Carriers for the Treatment of Ovarian Cancer 2021-05-15 10.5530/ijper.55.2.70 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-330.pdf Purpose: To summarize main findings from research on oral delivery of Nanostructured lipid carriers targeting ovarian cancer. Methods: A narrative review of all the relevant papers known to author was conducted. Results: Ovarian cancer is one of the most common gynaecologic cancer, the frontline treatments for which are surgical approach followed by radiotherapy or chemotherapy. Chemotherapy has its own limitations; consequently, there is a need to develop a targeted drug delivery system with hi Ovarian cancer, Nanostructured lipid carriers, Dual targeting, Chemotherapy, Oral delivery https://www.ijper.org/article/55/2/491-497 2026-04-13T05:54:38.118918+00:00 The Effects of Asphodel (Asphodelus aestivus Brot.) Rhizome Extract Administration in the Treatment of Thermally Induced Wound in Rats 2021-05-15 10.5530/ijper.55.2.87 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-491.pdf Background: Burn wound is an important health problem worldwide. Serious outcomes related with burn occur and treatments focus on healing of the wounded area with dermal preparations containing chemicals avoiding growth of pathogenic organisms. Plants are important sources for both modern pharmacy to find new molecules used in modern medication as well as in traditional medicinal practices. Many plants are used for treatment of burn wounds. Asphodel (Asphodelus aestivus Brot.) is a naturally fou Burn, Asphodel, Asphodelus, Rat, Skin, Ethnopharmacology https://www.ijper.org/article/55/2/395-406 2026-04-27T08:51:40.142963+00:00 Central Composite Design Aided Formulation Development and Optimization of Clarythromycin Extended-Release Tablets 2021-05-15 10.5530/ijper.55.2.77 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-395.pdf Objectives: The present work was designed to formulate extended-release tablets of clarithromycin by means of central composite design. To assess the systematic considerate of input and output variables and to construct design space, the central composited design was used. Methods: The concentrations of tamarind kernel powder (X1), ethyl cellulose (X2) and polyvinyl pyrrolidone (X3) remained as independent variables and responses were drug release in 2 h, 8 h and t50%. Polynomial equations were Tamarind kernel powder, Ethyl cellulose, Polyvinyl pyrrolidone, Clarithromycin, Central composite design, Extended release https://www.ijper.org/article/55/2/590-597 2026-04-27T09:05:45.379185+00:00 Development and Validation of Stability Indicating UV-Spectrophotometric Method for the Simultaneous Estimation of Telmisartan and Metformin Hydrochloride in Bulk Drugs 2021-05-15 10.5530/ijper.55.2.98 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-590.pdf Background: In present work attempt has been made to develop and validate a simple and sensitive UV spectrophotometric method for simultaneous estimation of Telmisartan and Metformin Hydrochloride. Objectives: To develop simple, precise, robust, sensitive and accurate UV-Spectrophotometric method for the simultaneous estimation of Telmisartan and Metformin HCl and to formulate the combined tablet dosage formulation of Telmisartan and Metformin HCl respectively. Methods: The optimum condition for Telmisartan, Metformin HCl, Method validation, ICH guidelines, Stability, indicating, UV-Spectrophotometric https://www.ijper.org/article/55/2/483-490 2026-04-13T05:54:38.118918+00:00 In silico Study, Protein Kinase Inhibition and Antiproliferative Potential of Flavonoids Isolated from Bassia eriophora (Schrad.) Growing in KSA 2021-05-15 10.5530/ijper.55.2.86 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-483.pdf Introduction: Kinase enzymes play an important role in cellular proliferation, the main target in cancer treatment is to inhibit their functions. Protein kinase inhibitors as flavonoids can be applied for prevention or treatment of cancers through inhibition of cell proliferation. Objectives: To isolate cytotoxic metabolites from B. eriophora, evaluate their antiproliferative and protein kinase inhibitory effects, as well as the in silico study for active compounds. Materials and Methods: Prepar Bassia eriophora, Antiproliferation, in silico study, Flavonoids, Protein kinase https://www.ijper.org/article/55/2/374-382 2026-04-27T08:46:07.533034+00:00 Design and Characterization of Sustained Release in situ Gastric Floating Gel of Ropinirole Hydrochloride 2021-05-15 10.5530/ijper.55.2.75 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-374.pdf Background: This in situ solution which on gelation floats in the gastric region is suitable for sustaining the release of the drug. In the present research work, Ropinirole Hydrochloride which is an Anti-parkinson agent, used to formulate an in situ gel for prolonged action. Materials and Methods: Sodium alginate is a natural polymer used to form the gel matrix, calcium carbonate plays a dual role i.e. the source of CO2 entrapped in the matrix for floatation of gel and source of Ca2+ ion for so In situ gel, pH induced ion gelation, Sodium Alginate, CaCO3, Gastro, Retentive, Ropinirole Hydrochloride https://www.ijper.org/article/55/2/383-394 2026-04-13T05:54:38.118918+00:00 Design and Investigation of Alginate Coated Solid Lipid Nanoparticles for Oral Insulin Delivery 2021-05-15 10.5530/ijper.55.2.76 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-383.pdf Introduction: The conventional subcutaneous administration of insulin has been associated with several limitations leading to poor patient compliance. The poor oral bioavailability of insulin due to degradation by gastrointestinal enzymes and secretions can be countered by the use of protective carriers such as solid lipid nanoparticles that are capable of being taken up by the Peyer’s patches. The aim of the investigation was to design and investigate alginate coated solid lipid nanoparticles ( Solid lipid nanoparticle, Insulin, Oral delivery, Sodium alginate, Glycerol, monostearate, Hypoglycemia https://www.ijper.org/article/55/2/598-606 2026-04-13T05:54:38.118918+00:00 RP-HPLC Accelerated Degradation Method Development and Validation for Determination of Amlodipine and Atorvastatin in Combination Dosage Form of Tablet 2021-05-15 10.5530/ijper.55.2.99 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-598.pdf Aim: The Cost effective, Accurate, Precise Accelerated degradation method has been developed for determination of Atorvastatin and Amlodipine in combination dosage form of tablet and validated as directed by ICH guidelines. Objectives: To develop and validate analytical method which can be easily adoptable in frequent analysis of Amlodipine and Atorvastatin combinations in the laboratories. Materials and Methods: The 0.02 M potassium dihydrogen phosphate: acetonitrile: methanol (30:10:60 v/v/v) Amlodipine, Atorvastatin, RP-HPLC, ICH Guidelines, PDA Detector, Validation https://www.ijper.org/article/55/2/550-555 2026-04-27T09:00:43.398908+00:00 Punicalagin Suppresses LPS-induced Inflammatory Responses in Murine Macrophages via JAK/STAT Signaling Pathway and Zymosan-induced Mice Paw Edema 2021-05-15 10.5530/ijper.55.2.93 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-550.pdf Aim: To investigate the anti-inflammatory activity of punicalagin (PUN) on mouse macrophages and the underlying mechanisms. Materials and Methods: Mouse primary peritoneal macrophages (PMs) were treated with lipopolysaccharide (LPS; 10μg/ml) and/ or PUN (50μM) for 4, 8 and 12 hr. The expression levels of inducible nitric oxide synthase (iNOS), interleukin (IL)-1β, IL-6, IL-12P40 and CCL-2 mRNAs were analyzed by qRT-PCR. Total iNOS, MAPK and JAK/STAT protein levels were measured by Western blotti Punicalagin, LPS-induced Inflammatory Responses, Macrophages, JAK/STAT, Paw edema https://www.ijper.org/article/55/2/463-473 2026-04-13T05:54:38.118918+00:00 Anti-Alzheimer’s Activity of Compounds from the Methanolic Extract of Lawsonia inermis Seeds: In vivo and in silico Molecular Docking Studies 2021-05-15 10.5530/ijper.55.2.84 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-463.pdf Background: Alzheimer's disease (AD) hallmark feature is neurodegeneration due to the accumulation of β-amyloid plaques and the formation of neurofibrillary tangles in the aged brain. The prevalence of AD in humans is doubled for every two decades and is expected to reach 74.7 million worldwide by 2030. Numerous treatment approaches for AD are currently available but success rate is very limited, therefore novel medicines that minimize AD progression are urgently needed. Methods: In this study, Alzheimer’s Disease, AChE, ACh, Cholinergic systems, Docking studies and, Lawsonia inermis https://www.ijper.org/article/55/2/474-482 2026-04-27T08:57:00.944842+00:00 Formulation of Alkaloid Loaded Phytosomes from Tinospora cordifolia and ex-vivo Intestinal Permeability Study 2021-05-15 10.5530/ijper.55.2.85 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-474.pdf Background: Phytosomes are newly introduced novel dosage form for improving the bioavailability and therapeutic effect of the herbal drug. The present study aimed to prepare and evaluate the alkaloid loaded phytosome from Tinospora cordifolia. Materials and Methods: Extracts were screened for total content of phenols, flavonoids and alkaloids. The prepared extract was further used for fractionation and dichloromethane fraction (F3) was used to prepare phytosomes. Phytosome was prepared by using Phytosomes, Tinospora cordifolia, Permeability, Soya lecithin, Cholesterol https://www.ijper.org/article/55/2/336-345 2026-04-13T05:54:38.118918+00:00 Overview of FBO Licensing in the India and New Dietary Ingredient Notification in the US 2021-05-15 10.5530/ijper.55.2.71 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-336.pdf The nutraceuticals in India are termed as "Foods for Special Dietary Uses" Food Safety and Standards Authority describes "Nutraceuticals provide a physiological benefit and help to maintain good health." FSSAI was recognized in India under the 2006 Food Safety and Standards Act, combines several acts and guidelines that existed in various ministries and departments to deal with food related substances. In US regulation, dietary supplements define “dietary supplement in part as product taken by m FSSAI, Nutraceuticals, Dietary Supplements, Food Business Operator, DSHEA https://www.ijper.org/article/55/2/614-620 2026-04-27T09:07:06.733665+00:00 Rapid Purification of Drug Enantiomers using Supercritical Fluid Chromatographic Method: Ibuprofen as a Model Compound 2021-05-15 10.5530/ijper.55.2.101 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-614.pdf Background: The purification of drug enantiomers is an essential technique because pharmacological activity differs depending on individual enantiomers. Nowadays, supercritical fluid technology is utilized for various purposes in the pharmaceutical field. Methodology: In this study, an efficient and streamlined method development strategy for finding an effective analytical method in supercritical fluid chromatography (SFC) is presented in detail for scaling up to preparative scale and achieving Ibuprofen, Analytical supercritical fluid chromatography (Analytic-SFC), Preparative supercritical fluid chromatography (Prep-SFC), Drug, Enantiomer, Purification https://www.ijper.org/article/55/2/507-516 2026-04-13T05:54:38.118918+00:00 Anti-inflammatory and Anti-arthritic Activity of Rosmarinic acid Isolated from Rosmarinus officinalis in an Experimental Model of Arthritis 2021-05-15 10.5530/ijper.55.2.89 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-507.pdf Background: Rosmarinus officinalis L. (family Lamiaceae is a perennial herb or small woody evergreen tree, commonly known as rosemary, which is native to the Mediterranean and Asia and reasonably hardy in cool climates. It has been used as a decoction in traditional Unani and Swedish medicine for the treatment of inflammatory diseases. Aim: To isolate rosmarinic acid (RA) from R. officinalis. leaf extract and to evaluate its protective effects against Freund’s adjuvant-induced arthritis in rats. Freund’s adjuvant-induced arthritis, Rosmarinic acid, Rosmarinus officinalis L, Histopathology, Inflammation https://www.ijper.org/article/55/2/445-454 2026-04-27T08:55:10.560436+00:00 Kalanchoe daigremontiana: Functional Properties and Histopathological Effects on Wistar Rats under Hyperglycemia-inducing Diet 2021-05-15 10.5530/ijper.55.2.82 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-445.pdf Introduction: Diabetes is a worldwide pandemic disease with an expensive way of control. Locals around the world have been used botanical extracts to reduce the effects of this deadly disease to improve the quality of life of the patients. Objectives: To evaluate the effects of crude extracts of the ethnobotanical species K. daigremontiana on a hyperglycemia rat model to support its antidiabetic use in traditional medicine. Materials and Methods: Crude leaves extract were daily administered per Traditional medicine, Anti-hyperglycemic, Diabetes Sucrose-rich diet, Kalanchoe daigremontiana, Phytotherapy https://www.ijper.org/article/55/2/498-506 2026-04-27T08:58:04.389744+00:00 Phytochemical Screening, HPTLC Finger Print and in vitro Antioxidant Activity of Bark Extracts of Lannea coromandelica (Houtt.) Merr. 2021-05-15 10.5530/ijper.55.2.88 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-2-498.pdf Background: Lannea coromandelica Merr (Houtt.) is used as a common medicinal plant among the tribal communities of Bangladesh has long been used in indigenous medicine for curing certain health disorders. Phytochemicals present in the bark are associated with their therapeutic capabilities. Objectives: The study was aimed to evaluate the HPTLC finger printing and in vitro antioxidant activity of methanol extract (MELC) and aqueous extract (AELC) of L. coromandelica bark extracts. Materials and M Lannea coromandelica houtt, Phytochemistry, in vitro antioxidant activity, Physicochemical parameters, HPTLC https://www.ijper.org/article/55/1s/S293-S302 2026-04-27T07:56:03.775099+00:00 Smart UV Derivative Spectrophotometric Methods for Simultaneous Determination of Metformin and Remogliflozin: Development, Validation and Application to the Formulation 2021-03-23 10.5530/ijper.55.1s.62 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-293.pdf Background: The result of pharmaceutical industry research for the new class and the new combination of drugs for the treatments of diabetes is the newly approved combination of metformin (MET) and remogliflozin (REM). For the quality control of this formulation, three smart, reproducible and non-sophisticated spectroscopic techniques were developed by modification of UV spectra. Materials and Methods: The first two methods were based on the measurements of the peak height of the third derivativ Metformin, Remogliflozin, UV, Derivative spectroscopy, Validation, Formulation https://www.ijper.org/article/55/1s/S122-S134 2026-04-13T05:54:51.605983+00:00 Acyclovir Loaded Solid Lipid Nanoparticulate Gel for Ocular Delivery: Optimization by using Factorial Design 2021-03-23 10.5530/ijper.55.1s.43 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-122.pdf Background: Acyclovir is a potent antiviral agent primarily used to treat viral infection in the eye, signified as Herpes Simplex Keratitis caused by Herpes Simplex Virus-1. But its applications are limited because of its poor oral bioavailability and permeability caused by significant first-pass metabolism. Objectives: The study is to design the formulation, optimization, in-vitro, ex-vivo and in-vivo characterization of solid lipid nanoparticulate gel (SLNG) of acyclovir and inspect their poss Acyclovir, Hot homogenization, Factorial design, Drug entrapment efficiency, Transcorneal study, Pharmacokinetic study https://www.ijper.org/article/55/1s/S11-S28 2026-04-27T07:36:15.170034+00:00 Niosome as a Novel Pharmaceutical Drug Delivery: A Brief Review Highlighting Formulation, Types, Composition and Application 2021-03-23 10.5530/ijper.55.1s.34 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-11.pdf Aim: Formation of niosome by using non-ionic surfactant. The particle size of niosome must be required in the range in between 10 nm -100 nm. This is just due to avoid the aggregation of niosome and show proper result. Materials and Methods: There are many types of niosome, their types and size depend on which method used for preparation. In this article we covered method of preparation of pro-niosome and niosome. Many factors are affecting formation of niosome such as drugs, its chemical and ph Niosome, Pro-niosome, Non-ionic surfactant, Preparation, Application https://www.ijper.org/article/55/1s/S285-S292 2026-04-27T07:51:56.337006+00:00 Development and Validation of UV Spectrophotometric Method for Estimation of Tea Tree Oil in Bulk and Cosmeceutical Creams 2021-03-23 10.5530/ijper.55.1s.61 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-285.pdf Background: Tea tree oil, also known as Melaleuca alternifolia essential oil is widely used in skin care cosmeceuticals for its antibacterial, antifungal, analgesic and anti-inflammatory effect. The complex and variable composition of the oil poses many challenges to the analytical chemist and a recent survey of analytical methods indicated only a few simple and validated methods for estimation of the oil. Aim: A quality by design approach has therefore been adopted to develop a simple and novel Tea tree oil, UV spectrophotometry, Box Behnken design, Optimization, Routine determination, Cosmeceutical cream https://www.ijper.org/article/55/1s/S259-S264 2026-04-27T07:51:00.239649+00:00 Translational Allergy and Omalizumab: The Pioneer 2021-03-23 10.5530/ijper.55.1s.58 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-259.pdf Backgound: The introduction of monoclonal antibodies into therapy has brought great progress in every field of medicine. Omalizumab is the first monoclonal antibody successfully used in allergology. We wanted to evaluate the impact in the medical literature of this molecule. Materials and Methods: We have identified omalizumab as the reference molecule in clinical allergology to evaluate the impact of the translational approach in this field throw the amount of data present in the literature on Allergy, IgE, Atopy, Omalizumab, Asthma, Atopic dermatitis, Translational, allergy, Translational medicine https://www.ijper.org/article/55/1s/S202-S208 2026-04-27T07:49:03.676712+00:00 Biogenic Synthesis of Silver Nanoparticles (AgNPs) using Solanum indicum Linn. 2021-03-23 10.5530/ijper.55.1s.51 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-202.pdf Background: Synthesis of silver nanoparticles (AgNPs) using green plants is important for biocompatibility, reduced hazards, green policy and eco-friendliness. Materials and Methods: In this study, a leaf extract of Solanum indicum and associated AgNPs were used to examine larvicidal properties and other biological activities. AgNP forms were characterized with scanning electron- microscopy (SEM), Fourier Transform Infrared Radiation spectroscopy (FTIR) and UV-vis spectra. Larvicidal activity wa Cytotoxic effect, Culex pipiens, Silver Nanoparticles, Antibacterial, Larvicidal, Solanum indicum https://www.ijper.org/article/55/1s/S225-S232 2026-04-13T05:54:51.605983+00:00 In-vitro and in-vivo Immunomodulatory Effect of Polyherbal Suspension on Cyclophosphamide Induced Experimental Animal 2021-03-23 10.5530/ijper.55.1s.54 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-225.pdf Aim: The aim of present investigation was to determine the efficacy of a polyherbal formulation. [Composed of Nelumbo nucifera (NN), Euryale ferox (EF) and Trapa natans (TN)]. Materials and Methods: The seeds of NN and EF and fruits of TN were extracted using hydroethanol (1:1) solvent. The dried extract of each plant was used for phytochemical investigation and DPPH radical scavenging activity to determine antioxidant activity. Polyherbal suspension (PHS) was prepared using dried extracts with Neutrophil adhesion, Phytochemistry, Nelumabo nucifera, Euryale ferox, Trapa natans https://www.ijper.org/article/55/1s/S209-S219 2026-04-13T05:54:51.605983+00:00 Exploration of Elephant Foot Yam (Amorphophallus paeoniifolius) Starch: An Alternative Natural Disintegrant for Pharmaceutical Application 2021-03-23 10.5530/ijper.55.1s.52 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-209.pdf Aim and Objectives: The aim of the current study is to isolate the starch from elephant foot yam (Amorphophallus paeonifolius) and investigate its potential as a disintegrant in tablet formulation as compare to standard corn starch. The objective of the study is to explore the applications of natural resources and develop an alternative to commercially available starches. Materials and Methods: Starch was isolated by a simple method, evaluated for phytochemical and physico-chemical properties. T Elephant foot yam, Corn starch, Disintegrant, Fast Disintegrating tablet, Disintegration time, Wetting time https://www.ijper.org/article/55/1s/S251-S258 2026-04-13T05:54:51.605983+00:00 Therapeutic Interventions using Monotherapy versus Combination Therapy of Aloe vera and Omega-3 Fatty Acids on Gentamicin-initiated Renal Toxicity via Attenuation of Renal Biomarkers 2021-03-23 10.5530/ijper.55.1s.57 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-251.pdf Background and Aim: The proposed work was planned to evaluate the potential protective role of aqueous Aloe vera (AV) concentrate and/or Omega-3 fatty acids (O3FAs) against GM -initiated renal toxicity in rats. Materials and Methods: Thirty female Wistar-albino rats were distributed into five equivalent groups as follows: Normal control group, GM control group, GM + AV group (200 mg/kg, p.o.), GM + O3FAs group (100 mg/kg, p.o.), GM + AV + O3FAs group. All the treatments were administered for 10 Aloe vera, Gentamicin, Omega-3 fatty acid, TGF-β1, Fibronectin, NGAL https://www.ijper.org/article/55/1s/S157-S163 2026-04-13T05:54:51.605983+00:00 Evaluation of Controlled Release Patterns of Ornidazole using Bio-degradable Polymers and Determination of its Antibacterial Activity 2021-03-23 10.5530/ijper.55.1s.46 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-157.pdf Aim: Controlled release (CR) local drug delivery (LDD) devices are useful in periodontitis management since they facilitate prolonged maintenance of high antimicrobial concentrations in the periodontal pockets. The study aimed, to formulate and evaluate the in-vitro release pattern of Ornidazole (OZ) from three different biodegradable polymer films and to determine the antibacterial activity of released OZ on periodontal pathogens. Materials and Methods: Four samples of 3 LDD systems were formul Chitosan, Local drug delivery, Hydroxypropylcellulose, Ornidazole, Periodontitis https://www.ijper.org/article/55/1s/S233-S241 2026-04-13T05:54:51.605983+00:00 Synthesis, Identification and in-silico Approach for wound Healing Potential in Gnaphalium polycaulon Extracts 2021-03-23 10.5530/ijper.55.1s.55 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-233.pdf Aim/Background: The secondary metabolites can be identified from G. polycaulon and used as effective compounds for wound healing potential. The aims of the present study to identify the metabolites from G. polycaulon extracts by in silico study. Methods: The extraction of aqueous and methanolic G. polycaulon leaf extracts was subjected to characterization for silver nanoparticles. The phytoconstituents of the plant was analyzed by standard quantitative and quantitative methods. Then, the silver G. polycaulon, Silver nanoparticles, Wound healing, GCMS, Protein ligands, In silico analysis https://www.ijper.org/article/55/1s/S75-S86 2026-04-13T05:54:51.605983+00:00 Preparation, Characterization and Optimization of Repurposed Valproic Acid Loaded Carboxymethyl Chitosan Nanoparticles by Box–Behnken Design for Alzheimer Management 2021-03-23 10.5530/ijper.55.1s.39 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-75.pdf Aim/Background: Alzheimer’s disease (AD) is one of the most ominous diseases, leads dementia but highest unmet till today. The new strategy needed via repositioning due to the limitation of existing therapies. Valproic acid is one of the first line drugs for epilepsy and bipolar disorder showed neuroprotective potential by decreased Aβ production in AD. Methods: The objective of this research was to prepare the repurposed VPA loaded polymeric nanoparticles using carboxymethyl chitosan for manage Repositioning, Valproic acid, Design of Experiment, In vitro cell line study, Ex vivo study https://www.ijper.org/article/55/1s/S184-S192 2026-04-13T05:54:51.605983+00:00 Protective Effect of Plumeria obtusa Leaves Extracts on Dexamethasone-induced Insulin-resistance Diabetes Mellitus in Rats 2021-03-23 10.5530/ijper.55.1s.49 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-184.pdf Background: Plumeria obtusa L., a potential medicinal plant, is still unexplored for its anti-diabetic effect. The objective of this study was to examine the protective effect of Plumeria obtusa leaves extracts on insulin-resistance diabetic rat model. Materials and Methods: Male Wistar rats were distributed into twelve groups. Dexamethasone was used to induce insulin-resistance diabetes mellitus. Three different doses of each extract (petroleum ether, ethanol and aqueous) were orally administer Plumeria obtusa, Insulin-resistance diabetes mellitus, Lipid profile, Insulin, Scanning electron microscopy https://www.ijper.org/article/55/1s/S149-S156 2026-04-13T05:54:51.605983+00:00 Investigation of Solubility of Mebendazole Drug using Linear Prediction and Multilayer Feed Forward Neural Network 2021-03-23 10.5530/ijper.55.1s.45 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-149.pdf Objectives: A systematic in-vitro study has been achieved to decide the stability of a selection of three presidential hydrotropes to decorate the obvious aqueous solubility of the sparingly water- soluble drug, mebendazole drug. This study is that the ANN model to be prediction the solubility of the mebendazole drug among the chemical substances. Methodology: These experimental data, together with a selection of recounted and estimate physico-chemical consequences of the hydrotropes are after t Mebendazole Drug, Solubility, Hydrotropes, Mathematical Model, Artificial, Neural Networks https://www.ijper.org/article/55/1s/S87-S99 2026-04-13T05:54:51.605983+00:00 Studies on Formulation and Evaluation of Eudragit RS PO Based Nanoparticulate System of Aceclofenac for Ocular Delivery 2021-03-23 10.5530/ijper.55.1s.40 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-87.pdf Aim: Ocular drug delivery is the most challenging and interesting goal in front of the pharmaceutical scientist. Ocular inflammation is the most commonly affecting disease of the eye. The objectives of present investigation were to formulate and evaluate eudragit RS PO (ERS PO) based Aceclofenac (ACF) Nano suspension for ophthalmic application. Materials and Methods: The ACF Nano suspensions were prepared by Nano precipitation method and the optimized formulation was lyophilized and further char Aceclofenac, Nanosuspension, Occular, Eudragit, Permeation https://www.ijper.org/article/55/1s/S318-S324 2026-04-13T05:54:51.605983+00:00 Clinical Pharmacist Approach towards Effectiveness of Pulmonary Rehabilitation of the Patient with COPD: A Randomized Controlled Study 2021-03-23 10.5530/ijper.55.1s.65 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-318.pdf Background: COPD is characterized by chronic obstruction of lung airflow that interferes with normal breathing and is not fully reversible. Pulmonary rehabilitation is widely accepted as a best result outcome treatment for COPD patients. Clinical pharmacist play a very important role in patient prescription analysis, promoting the Quality of life, patient education, in developing the drug regimen, sensitivity and allergic condition of the patient to the drugs, finding out any ADRs. Objectives: T COPD, Pulmonary rehabilitation, Collaborative approach, Pharmacist’s, intervention, Pharmaceutical care, Quality of life https://www.ijper.org/article/55/1s/S220-S224 2026-04-13T05:54:51.605983+00:00 Silver Nanoparticles Biosynthesized from Vaccinium myrtillus L. against Multiple Antibiotic Resistance and Biofilm Forming Escherichia coli and Pseudomonas aeruginosa 2021-03-23 10.5530/ijper.55.1s.53 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-220.pdf Background: Despite new innovations and process improvements, biofilm forming bacterial infections still pose a serious threat to patients. Silver nanoparticles (AgNPs) have been shown to have antibacterial properties and have been applied for surface manufacturing of many permanent medical devices at the same time. Therefore, we attempted to compare the performance of green synthesis of AgNPs and Vaccinium myrtillus L. plant extracts in terms of antibacterial and antibiofilm potential against m E. coli, P. aeruginosa, Biofilm, Vaccinium myritillus, Nanoparticle https://www.ijper.org/article/55/1s/S312-S317 2026-04-13T05:54:51.605983+00:00 Investigation of the Effects of Polypharmacy on Cognitive Functions: Cohort Study 2021-03-23 10.5530/ijper.55.1s.64 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-312.pdf Background: Alzheimer’s Disease (AD) is a major concern in growing chronic diseases in the geriatric society and its connection with polypharmacy has not been sufficiently understood. Aim: This Study investigate the association between Alzheimer’s disease and polypharmacy. Methods: A prospective cohort study. Patients with diagnosis of the AD and being older than 55 included in study between March 2017 and September 2017 who applied at the Bezmialem Vakif University Hospital, Istanbul. According Alzheimer’s disease, Dementia, Polypharmacy, Elderly, KATZ-ADL, MMSE https://www.ijper.org/article/55/1s/S164-S174 2026-04-13T05:54:51.605983+00:00 Development of Budesonide Oral Colon Specific Drug Delivery System using Interpolymer Complexation Method 2021-03-23 10.5530/ijper.55.1s.47 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-164.pdf Background: Oral bioavailability of Budesonide is 10% due to its extensive first pass metabolism, its high volume of distribution and 85-90% of protein binding. Protection of drug release in stomach and targeting drug to colon which is an absorption site of drug is an attempt to improve therapeutic efficacy. The objective of this study was to develop interpolymer complex microspheres of Budesonide for oral colon specific drug delivery. Methods: Emulsion solvent evaporation method was used in the Budesonide, Colon Specific Delivery, Interpolymer Complexation, Microspheres, Cellulose Acetate phthalate https://www.ijper.org/article/55/1s/S1-S10 2026-04-13T05:54:51.605983+00:00 Nano-transethosomes: A Novel Tool for Drug Delivery through Skin 2021-03-23 10.5530/ijper.55.1s.33 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-1.pdf Transdermal drug delivery has become a popular tool from last few years. It overcomes drawbacks which are encountered with the oral route. Though very few routes are as attractive as transdermal route, transport of drug through the skin is challenging. In order to overcome the challenges, researchers have found a system in which the drug is encapsulated into the vesicle and these vesicles can penetrate deeper into the skin to hit the target site. Hence, better skin penetration of bioactive agent Transdermal delivery system, Transethosomes, Vesicles, Skin permeation, Non-invasive, Entrapment efficiency https://www.ijper.org/article/55/1s/S56-S65 2026-04-13T05:54:51.605983+00:00 Solubility Enhancement of Oxcarbazepine by Melt Sonocrystallization Technique to Increase the Bioavailability 2021-03-23 10.5530/ijper.55.1s.37 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-56.pdf Objectives: The present study aimed to enhance the solubility of Oxcarbazepine by melt sono crystallization technique as well as increase its bioavailability. Materials and Methods: Tablets of Melt Sonocrystallized Oxcarbazepine were prepared by the direct compression method. Compression was performed on a Remik mini-press tablet compression machine using an 8mm punch. The analytical method development was carried out in 20x10 and 10x10 twin trough chambers. The sample was spotted with a 100μl c Melt sonocrystallized, Oxcarbazepine, Method development, HPTLC, Validation, Solubility Enhancement https://www.ijper.org/article/55/1s/S100-S111 2026-04-13T05:54:51.605983+00:00 Gastroretentive Floating Tablets Enclosing Nanosponge Loaded with Lafutidine for Gastric Ulcer: Formulation and Evaluation 2021-03-23 10.5530/ijper.55.1s.41 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-100.pdf Aim and Objectives: The present study aimed to formulate and evaluate gastroretentive nanosponge loaded with lafutidine for a gastric ulcer to overcome the drawbacks of oral conventional dosage forms such as the inability to confine and locate within the desired region of the gastrointestinal tract due to variable gastric emptying and motility. The floating tablets of nanosponge were formulated to increase the bioavailability of lafutidine by prolonging retention time in the upper gastric region Nanosponge, Lafutidine, Design of experiment (DoE), Gastroretentive, Floating tablet https://www.ijper.org/article/55/1s/S193-S201 2026-04-13T05:54:51.605983+00:00 Response Surface Optimization of Flavonoids Extraction, Beta Carotene Bleaching and Lipid-reducing Capacity of Nelumbo nucifera Seed Kernel Extracts 2021-03-23 10.5530/ijper.55.1s.50 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-193.pdf Aim/Background: The safe and complete extraction of flavonoids from plant material influenced by various factors has been ever challenging for the researchers. The study was planned to optimize the extraction of flavonoids from nucifera seeds and their antioxidant activity. Materials and Methods: The flavonoids were extracted at various combination of four extraction factors including particle size of the flour in terms of sieve number (SN), microwave treatment time (MTT), concentration of metha Linoleic acid reduction capacity, Lotus seed kernel, Microwave-assisted, extraction, Nelumbo nucifera seed, Response surface methodology, Total flavonoids, content https://www.ijper.org/article/55/1s/S29-S47 2026-04-13T05:54:51.605983+00:00 Natural Chimeras of Existing Drugs for Alzheimer’s Disease: Expanding the Target Landscape 2021-03-23 10.5530/ijper.55.1s.35 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-29.pdf Alzheimer’s disease (AD) has emerged as a complex, multi-faceted, neurodegenerative disorder. Multiple mechanisms seem to play a part in its pathogenesis, including amyloid beta aggregation, cholinergic deficit, oxidative stress and neuroinflammation. The current FDA-approved anticholinesterase drugs addressing a single mechanism have turned out to be palliative rather than curative. A number of natural medicinal bioactive are known, which have the potential to overcome many of the unaddressed c Alzheimer disease, Natural bioactives, Cholinesterase inhibitors, Antioxidants, Chimeric compounds, Hepatotoxic https://www.ijper.org/article/55/1s/S242-S250 2026-04-13T05:54:51.605983+00:00 Biopreservative Action of Bacteriocin from Pediococcus pentosaceus on the Microbial Load of Apple Juice 2021-03-23 10.5530/ijper.55.1s.56 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-242.pdf Aim: The aim of the study is to explore the bio preservative role of Pediococcus pentosaceus. Background: Bacteriocins are proteinaceous or peptidic in nature produced by lactic acid bacteria and generally recognized as safe (GRAS). It ranges from 2 to 200kDa in molecular weight. It inhibits the growth of similar or closely related bacterial strains. Materials and Methods: In this experiment, “Appam batter” has been taken as our sample, collected from Vellore city. The sample was fermented for s Appam batter, Lactic Acid Bacteria, Purification, Bacteriocin, Apple juice, Preservative https://www.ijper.org/article/55/1s/S275-S284 2026-04-13T05:54:51.605983+00:00 Docking Studies and Evaluation of Antimicrobial Activity of Chroman Carboxamide Derivatives 2021-03-23 10.5530/ijper.55.1s.60 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-275.pdf Aim: Based on our previous work, a series of chroman derivatives, which were first used as antiepileptic agents, are evaluated for their antimicrobial potency. Materials and Methods: The present study involves docking studies, synthesis and evaluation of in vitro antimicrobial activity against seven bacterial strains and two fungal strains.The activity was tested by agar well dilution and serial tube dilution methods. Results: The majority of the compounds displayed good to excellent antimicrobi Antimicrobial agents, Chroman derivatives, Turbidity, Zone of Inhibition, MIC https://www.ijper.org/article/55/1s/S176-S183 2026-04-13T05:54:51.605983+00:00 Evaluation of Some Phenolic Acids in Diabetic Neuropathy 2021-03-23 10.5530/ijper.55.1s.48 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-176.pdf Background: Streptozotocin (STZ) induced neuropathy is widely used preclinical model for diabetic neuropathy (DN). DN is majorly resulted due to nitrosative and oxidative stress induced by hyperglycemia. Phenolic acids are polyphenols with free radical scavenging anti-inflammatory and neuroprotectiveaction. Methods: In this study STZ (55mg/kg, i.p) was administered in male Wistar rats and animals with hyperglycemia (fasting blood glucose ≥ 200mg/dl) were used for further study. Behavioural chang Key words: Phenolic acids, Neuropathy, Hyperalgesia, Allodynia, Nerve conduction, velocity, Antioxidants, Cytokines https://www.ijper.org/article/55/1s/S265-S274 2026-04-13T05:54:51.605983+00:00 Ethanolic Extract of Capparis decidua Fruit Ameliorates Methotrexate-Induced Hepatotoxicity by Activating Nrf2/HO-1 and PPARγ Mediated Pathways 2021-03-23 10.5530/ijper.55.1s.59 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-265.pdf Introduction: Methotrexate, a folate antimetabolite, immunosuppressant and cytotoxic chemotherapeutic agents employed for malignant conditions. Continuous exposure of methotrexate produces adverse side effects especially liver toxicity. Recently, medicinal plants are gaining an importance owing to their phytoconstituents which are responsible for their medicinal value. Capparis decidua is one such medicinal plant widely used in the traditional system of medicine. No study has focused the mechani Antioxidant, Capparis decidua, Hepatotoxicity, Methotrxate, Nrf2, PPARү https://www.ijper.org/article/55/1s/S112-121 2026-04-13T05:54:51.605983+00:00 Formulation and Evaluation of Orodispersible Tablets of Apremilast by Inclusion Complexation using β-Cyclodextrin 2021-03-23 10.5530/ijper.55.1s.42 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-112.pdf Introduction: The present study was carried out to formulate and evaluate orodispersible tablets of Apremilast with a purpose of providing better patient compliance to geriatric, pediatric, impaired, travelling and non-cooperative patients suffering from psoriasis. Such patients are in need of fast and easy swallowing drug delivery system. Materials and Methods: The Apremilast-β-cyclodextrin inclusion complex was prepared by physical blending method with a principle of increasing the solubility Psoriasis, Orodispersible Tablet, Inclusion Complexation, Apremilast-β, cyclodextrin, Croscarmellose sodium https://www.ijper.org/article/55/1s/S48-S55 2026-04-13T05:54:51.605983+00:00 Bioactive Compound Bisacurone in the Turmeric Extract (Turcuron) Prevents Non-alcoholic Fatty Liver Disease by Reduction of Lipogenesis 2021-03-23 10.5530/ijper.55.1s.36 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-48.pdf Objectives: The current study was carried out to demonstrate potential role of Turcuron, a standardized turmeric extract containing 8% Bisacurone to protect against non-alcoholic fatty liver disease (NAFLD). Methods: HepG2 cell lines exposed to oleic acid (OA) and high-fat diet-induced hepatic steatosis in mice were used as experimental models to explore the hepatoprotective effects of Turcuron. The cytotoxicity was quantitatively assessed by MTT assay. Lipid accumulation and intracellular trigl NAFLD, Bisacurone, SREBP-1, Oil- O red, HFD https://www.ijper.org/article/55/1s/S66-S74 2026-04-13T05:54:51.605983+00:00 Transdermal Delivery of Fluconazole ß-cyclodextrin Complex Incorporated in Aloe vera Gel for Fungal Therapy: Development, Characterization and in vitro Evaluation 2021-03-23 10.5530/ijper.55.1s.38 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-66.pdf Aim: The aim of the present investigation was to increase the dissolution rate of Fluconazole by solid dispersion technique and then it was incorporated into the gel for better diffusion profile. Fluconazole, an imidazole derivative, is used for the treatment of various local and systemic fungal infections. Materials and Methods: FTIR reports suggested the compatibility between the drug and the excipients. Among all the twelve solid dispersions formulations (F1-F12) prepared by two different met Fluconazole, β-cyclodextrin solid dispersion, Solvent evaporation, Aloe vera, PVP, Solubility enhancement, Transdermal delivery https://www.ijper.org/article/55/1s/S135-S148 2026-04-13T05:54:51.605983+00:00 Development of Raloxifene Hydrochloride Loaded mPEG-PLA Nanoparticles for Oral Delivery 2021-03-23 10.5530/ijper.55.1s.44 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-135.pdf Objectives: Raloxifene hydrochloride is used in the treatment of breast cancer which suffers from poor bioavailability problem i.e., only 2% due to excessive first pass metabolism. Development of a delivery system to overcome its bioavailability problem can be done by using mPEG-PLA polymeric nanoparticles which has many scientific applications. Methods: mPEG-PLA polymer has been prepared and evaluated using NMR, FTIR and GPC. Nanoparticles were prepared using emulsion-diffusion-evaporation tech First pass metabolism, mPEG-PLA, Nanoparticles, Emulsion diffusion, evaporation method, Bioavailability and Higuchi diffusion https://www.ijper.org/article/55/1s/S303-S311 2026-04-13T05:54:51.605983+00:00 Quantification of Fluoxetine in Human Plasma by the Development of Liquid Chromatography-tandem Mass Spectrometry Method 2021-03-23 10.5530/ijper.55.1s.63 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1s-303.pdf Aim: The aim of this research paper is the development and validation of an easy, selective and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of fluoxetine in human K3EDTA plasma and application of this method on bioequivalence studies of fluoxetine. Methods: As Amitriptyline belongs to same category drug so, it was selected as an internal standard for the quantification of fluoxetine. The protein precipitation (PPT) method was used to extract Fluoxetine, LC-MS/MS, Amitriptyline, Human plasma, Protein Precipitation, Pharmacokinetic https://www.ijper.org/article/55/1/205-214 2026-04-13T05:23:58.627931+00:00 Antiproliferative Potential of Ethyl acetate Extract of Clerodendrum thomsoniae Balf.f. on DMBA-induced Breast Cancer in Female Sprague-dawley Rats 2021-02-15 10.5530/ijper.55.1.23 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-205.pdf Background: Clerodendrum is a genus of around 500 species that has a place with the family Lamiaceae. Numerous types of this class have been demonstrated for the treatment of different maladies including cancer. This study aimed to investigate the anti-cancer activity of ethyl acetate fractions of Clerodendrum thomsoniae Balf.f. (EACT) in female Sprague-Dawley rats. Methods: 7, 12-dimethylbenz (a) anthracene (DMBA) was used to induce breast cancer. Two doses of (25 and 50 mg/kg) EACT were used f Clerodendrum thomsoniae Balf.f, 2, 4-bis(1-phenylethyl)-phenol, Breast, cancer, EACT, Antiproliferative potential https://www.ijper.org/article/55/1/240-248 2026-04-13T05:23:58.627931+00:00 Tribulus terrestris Saponins Improve Ovarian Ischemia-reperfusion Injury in Female Rats: Modulation of Vascular Endothelial Growth Factor-A and Hemeoxygenase-1 2021-02-15 10.5530/ijper.55.1.27 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-240.pdf Aim/Background: Ovarian I/R is a popular gynecological emergency, complicating ovarian torsion. TTS, reported to have many therapeutic effects along with being an antioxidant, anti- inflammatory and anti-apoptotic agent. The aim of this study was to estimate the probable protective role of Tribulus terrestris Saponin (TTS) in recovering the damaging effects of ischemia-reperfusion (I/R) in the female rats' ovarian tissue. Materials and Methods: TTS was treated to female rats in presence or absen Apoptosis, Angiogenesis, Immunohistochemical study, Ovarian ischemia/, reperfusion, Tribulus terrestris saponin https://www.ijper.org/article/55/1/95-106 2026-04-13T05:23:58.627931+00:00 Preformulation Considerations Development and Evaluation of Mesalamine Loaded Polysaccharide-Based Complex Mucoadhesive Beads for Colon Targeting 2021-02-15 10.5530/ijper.55.1.13 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-95.pdf Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of large intestine consisting of ulcerative colitis and Crohn’s disease. Mesalamine is a first line drug use for the treatment but it has drawback of low water solubility and low permeability. In addition, oral drug delivery to colon faces the problem of gastric degradation and thus increases dose size and frequency. Objectives: The present study was aimed to assay mesalamine and develop an enteric coated mesalamine l Inflammatory bowel disease, Colon, Mesalamine, Mucoadhesion, Beads https://www.ijper.org/article/55/1/1-10 2026-04-13T05:23:58.627931+00:00 Cucurbita pepo and Cucurbitacin in the Management of Anti-proliferation by JAK/STAT Pathway 2021-02-15 10.5530/ijper.55.1.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-1.pdf Pumpkin (Cucurbita pepo) is capaciously recycled similar to food and in folk medicine throughout the world. It accords to genus Cucurbita (CCT) under family Cucurbitaceae. There are a plenty of important medicinal phyto-constituents belonging to cucurbitoside like triterpenoids, CAR T and CCT glycosides. A survey of the literature demonstrates that C. pepo, has the capacity to improve prostatic hyperplasia, urinary dysfunction and cytotoxic properties. Many pharmacological revisions have establi Anticancer activity, Cucurbita pepo, Cucurbitaceae family, JAK/STAT, pathway, Cucurbitacin, Cyclooxygenase-2 https://www.ijper.org/article/55/1/288-303 2026-04-13T05:23:58.627931+00:00 Re-Appraisal of the Effectiveness and Adverse Reaction between Cefazolin and Anti-Staphylococcal Penicillins for Treating Patients with Methicillin- Sensitive Staphylococcus aureus Bacteremia: Comprehensive Meta-analysis and Trial Sequential Analysis 2021-02-15 10.5530/ijper.55.1.32 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-288.pdf Objectives: Patients with methicillin susceptible Staphylococcus aureus bacteremia (MsSaB) are treated by cefazolin (Cfz) or anti-staphylococcal penicillin’s (ASPs) as the preference drug, although they may be not equally effective in some clinical scenarios. We performed a comprehensive meta-analysis and trial sequential analysis to assess the updated evidence comparing Cfz with ASPs in patients with MsSaB. Methods: We searched the databases including PubMed, Cochrane Central Register of Contro Meta-analysis, Anti-staphylococcal penicillin, Cefazolin, Staphylococcus, aureus, Bacteremia https://www.ijper.org/article/55/1/117-125 2026-04-13T05:23:58.627931+00:00 Doxorubicin Hydrochloride Loaded Polyanhydride Nanoformulations and Cytotoxicity 2021-02-15 10.5530/ijper.55.1.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-117.pdf This study aimed to evaluate DOX∙HCl loaded P(DLLA-CO:60:40) nanoformulations with a copolymer of F127 as a potential drug delivery system for cancer. DOX ∙ HCl was encapsulated in nanoformulations of Poly DL-lactic acid co castor oil 60:40, P(DLLACO: 60:40) polymer with the copolymer/stabilizer Pluronic® F127. The mean diameter of the cylindrical rod shape of the nanoformulation particles was 248±2.4-260±3.2 nm with an acceptable poly dispersibility of 0.29- 0.33 and a smooth surface as visuali Doxorubicin hydrochloride, MCF-7 breast cancer cell lines, Nanoformulations, Drug delivery https://www.ijper.org/article/55/1/190-197 2026-04-13T05:23:58.627931+00:00 Inhibitory Potential of Dietary Phytocompounds of Nigella sativa against Key Targets of Novel Coronavirus (COVID-19) 2021-02-15 10.5530/ijper.55.1.21 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-190.pdf Aim/Background: Dietary factors have shown important role in the rapid management of several human ailments including viral infections. Since ancient times, constituents of Nigella sativa seeds have been utilized as food preservatives with significant medicinal benefits in Unani and Ayurveda practices. Nigella sativa (Black seed) has presented significant therapeutic potential against several disorders and known to have numerous biological activities (such as antibacterial, antiviral and anti-in COVID-19, Nigella sativa, Molecular Docking, Dietary Phytocompounds, AutoDock https://www.ijper.org/article/55/1/164-173 2026-04-13T05:23:58.627931+00:00 Pharmacological Evaluation of Caesalpinia pulcherrima Leaf Extract for Anticancer Activity against Ehrlich Ascites Carcinoma Bearing Mice 2021-02-15 10.5530/ijper.55.1.18 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-164.pdf Objectives: The aim of the study is to assess the anticancer activity of Caesalpinia pulcherrima leaf extract against Erlich Ascites Carcinoma (EAC) in mice. Materials and Methods: BALB/c mice with Erlich Ascites Carcinoma were used for the present study. Ethanolic extract of C. pulcherrima (EECP) was administered p.o. in three different doses i.e. 200, 400 and 800 mg/kg body weight, after 24 hr of tumor inoculation in mice for 14 days. Effect of EECP on haematological parameters, liver enzymes Anticancer, Antioxidant, Caesalpinia pulcherrima, EAC, Malignancy https://www.ijper.org/article/55/1/276-287 2026-04-13T05:23:58.627931+00:00 Research on the Attitudes of the Elderly towards Interprofessional Cooperation and Collaborative Pharmacy Practices: Cross-sectional Study in Serbia 2021-02-15 10.5530/ijper.55.1.31 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-276.pdf Background: Population aging is taking place at the highest historical rates, while growing needs for healthcare by the elderly put added and immense pressure predominantly on the primary care. Higher level of interprofessional collaboration is expected to improve healthcare system performance and to provide adequate delivery of healthcare for the elderly. This was the main driver for implementing the interprofessional collaborative models by many countries. However, these models need to be pati Cross-sectional survey, Collaborative practice, Healthcare, Attitudes, Elderly https://www.ijper.org/article/55/1/153-163 2026-04-13T05:23:58.627931+00:00 Alpha7 Nicotinic Acetylcholine Receptor Down Regulation Impairs Mitochondrial Function in Streptozotocin-induced Sporadic Alzheimer's Disease Model in Rats 2021-02-15 10.5530/ijper.55.1.17 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-153.pdf Background/Aim: Alzheimer’s disease (AD), a type of neurodegenerative disorder, possesses significant memory loss as one of the cardinal manifestations. The pathophysiology of AD includes increased accumulation of Aβ, degeneration of cholinergic activity and mitochondrial dysfunction. Nicotinic acetylcholine receptors (nAChRs) especially alpha7 nicotinic acetylcholine receptors (α7 nAChRs) are widely distributed in brain and associated with memory function. Further, we explored the correlation b Alzheimer’s disease, Streptozotocin, α7 nAChR, Mitochondria, Acetylcholine, Hippocampus https://www.ijper.org/article/55/1/215-223 2026-04-27T07:32:23.778903+00:00 Ameliorative Effect of Multi Herbal Formulation on Lipid Peroxidation and Redox Dysfunction in Ethanol Induced Hepatic Imbalance 2021-02-15 10.5530/ijper.55.1.24 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-215.pdf Objectives: Traditional medicine is a potent antioxidant. In the present study, we developed a multi herbal formulation and examined its anti-oxidative activities and possible protective effect of it on serum and liver lipid peroxidation and glutathione in ethanol-induced hepatic dysfunction. Materials and Methods: In this experimental study 40 Swiss albino mice were divided into 4 groups randomly; group I as control, group II as sham treated with multi herbal formulation (MHF) (300mg/kg orally, Alcohol, Liver disease, Lipid Peroxidation, Mice, Herbal Formulation, Antioxidant enzymes https://www.ijper.org/article/55/1/146-152 2026-04-13T05:23:58.627931+00:00 Disposal of Uranium and Thorium Entering the Human Digestive System before Reaching the Blood by Adsorption on Simethicone and Forming a Non-absorbable Compound: A Full in vitro Analysis 2021-02-15 10.5530/ijper.55.1.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-146.pdf Introduction: This method was applied to form a non-absorbable complex with uranium and thorium swallowed with contaminated dust or other sources to get rid of them before absorption into the blood and discarded outside the body. A non-GIT absorbable simethicone was used in this method for the adsorption of uranium (VI) and thorium (IV) from a solution similar to the gastrointestinal tract pH medium. Materials and Methods: Accurately measured 9 mg of pure standard uranyl nitrate and simethicone Simethicone, Uranium, Thorium, Protection, Non-absorbable complex https://www.ijper.org/article/55/1/256-265 2026-04-13T05:23:58.627931+00:00 Docking Studies, Synthesis and Evaluation of Anticancer Activity of 4H-Chromene Derivatives 2021-02-15 10.5530/ijper.55.1.29 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-256.pdf Aim: The present study involves to design, synthesis and evaluate the anticancer activity of 4H-chromene derivatives (PKB 1-10) on human breast cancer MCF-7 cell line. Materials and Methods: 4H-chromene derivatives (PKB 1-10) were designed by docking, in silico ADME and predicted toxicity studies. These designed compounds were then synthesized by acid catalyzed Michael Addition of phenols to benzylidene oxobutanoates. These compounds were characterized by 1H NMR, 13C NMR, FTIR and melting point. Anticancer, 4H-chromenes, Docking, MCF-7 cell line, Toxicity https://www.ijper.org/article/55/1/56-62 2026-04-27T07:25:25.79948+00:00 Problem-based Learning Teaching Method Applied to Pharmaceutical Engineering Experiment Teaching Based on the Outcome-based Education Theory 2021-02-15 10.5530/ijper.55.1.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-56.pdf Objectives: Pharmaceutical engineering experiments are among the most important links in teaching of the pharmaceutical engineering specialty. This study aimed to reform the content of the experiment course for the pharmaceutical engineering specialty under the guidance of the outcome-based education (OBE) theory. Materials and Methods: We reformed the teaching content and methods of the pharmaceutical engineering experiment course at Zhejiang University of Science and Technology by using proble Outcome-based education, Problem-based learning, Pharmaceutical, engineering experiment, Evaluation system https://www.ijper.org/article/55/1/77-85 2026-04-13T05:23:58.627931+00:00 Formulation and Optimization of Atovaquone Micronized Suspension by Top-down Method 2021-02-15 10.5530/ijper.55.1.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-77.pdf Aim: The present work aimed to tackle the solubility issue of a Biopharmaceutics Classification System (BCS) II drug, Atovaquone. Methods: Formulation of micronized suspension of atovaquone was optimized by employing a 32 full factorial design keeping poloxamer 188 (wetting agent) and phospholipon 90H (stabilizer) as the influential variables affecting the dependent variables viz. particle size and polydispersity index (PdI). Selected formulations from the optimized design space were further eva Atovaquone, Micronized suspension, Microfluidization, Full factorial design, Solubility enhancement https://www.ijper.org/article/55/1/266-275 2026-04-13T05:23:58.627931+00:00 Design, Synthesis, Hypoglycemic Activity and Molecular Docking Studies of 3-substituted-5- [(furan-2-yl)-methylene]-thiazolidine-2,4-dione Derivatives 2021-02-15 10.5530/ijper.55.1.30 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-266.pdf Background: From the wide range of previous literature studies indicated that thiazolidinedione’s reacts with substituted benzaldehydes undergoes knoevenagel condensation gives respective arylidene derivatives. In our attempt all the titled compounds were designed and developed by replacement of substituted benzaldehydes with furan- 2-aldehyde, so that furan moiety was introduced in the molecule. Materials and Methods: 5-[(furan-2-yl)-methylene]-thiazolidine-2,4-dione was prepared via knoevenage Thiazolidinedione derivatives, Synthesis, Hypoglycemic Activity, Molecular, Docking, PDB ID-2PRG https://www.ijper.org/article/55/1/63-69 2026-04-13T05:23:58.627931+00:00 Students’ Perception and Expectation towards Pharmacy Education: A Qualitative Study of Pharmacy Students in a Developing Country 2021-02-15 10.5530/ijper.55.1.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-63.pdf Background: Pharmacy education is a vital element sustaining the supply of pharmacists to meet the needs in the social and health care sectors. Understanding the perception and expectation of pharmacy students towards their study is pivotal to the maintenance of public health services in a country. Objectives: This study uses China as a sample of developing countries and seeks implications for the future development of pharmacy education. Methods: A total of 20 undergraduate students majoring in Pharmacy, Education, Student engagement, Expectation, Motivation https://www.ijper.org/article/55/1/36-55 2026-04-13T05:23:58.627931+00:00 Pharmacological Actions of Contents of Kabasura Kudineer- A Siddha Formulation for Fever with Respiratory Illness 2021-02-15 10.5530/ijper.55.1.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-36.pdf Siddha system of medicine is a distinct therapeutic science with many single drugs and compound formulations used for treating a broad spectrum of ailments. Siddha categorizes the fever manifested by viral infestation into 64 types and it has developed medicines for each type. Kapacurak / Kabasurak Kutinir (KK) described in the Citta Vaittiyattirattu is the best promising polyherbal formulation of plant origin for curing viral infections especially with flu-like symptoms. As per Siddha system of AYUSH, Citta Vaittiyattirattu, COVID-19, Flu-like symptoms, Respiratory, illness, SARS, Traditional medicine https://www.ijper.org/article/55/1/136-145 2026-04-13T05:23:58.627931+00:00 Paralleling the Quality and Economy of Levofloxacin Hemihydrate and Cefuroxime Axetil Tablets 2021-02-15 10.5530/ijper.55.1.16 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-136.pdf Aim/Background: The Government of India has initiated different regulations and provisions to provide low cost medicines at affordable rates than the high cost medicines. The government has initiated Jan Aushadhi stores in every city and village of India with the motto of promoting quality medicines for all at economic price. Improving the public perception and addressing their doubts regarding the quality and efficacy of low-cost medicines is a big challenge in this endeavour. Materials and Met Levofloxacin hemihydrate, Cefuroxime axetil, Generic, Microbial assay, Pharmacopoeial evaluation https://www.ijper.org/article/55/1/107-116 2026-04-13T05:23:58.627931+00:00 Development and Characterization of Leuprolide Acetate Encapsulated PLGA Microspheres for Parenteral Controlled Release Depot Injection 2021-02-15 10.5530/ijper.55.1.14 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-107.pdf Objectives: Polylactic acid (PLA) and copolymer polylactic-co-glycolic acid (PLGA) are the most versatile drug carriers for long acting release injectable (LAI) formulations for small molecules, peptides and macromolecules such as proteins and nucleic acids. The present research work consists of a PLGA based one-month release microsphere formulation of GnRH agonist leuprolide acetate, using double emulsion (W1/O/W2) technique. Materials and Methods: Microparticles were prepared by double emulsio Leuprolide, PLGA Microspheres, Double-emulsion technique, Prostate cancer, Controlled release depot Injection https://www.ijper.org/article/55/1/26-35 2026-04-13T05:23:58.627931+00:00 A Brief Introduction of Clinical Chinese Pharmacy Education, Training and Practice in China 2021-02-15 10.5530/ijper.55.1.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-26.pdf In China, there are two types of pharmacists who work on either Western Medicine (WM) or Traditional Chinese Medicine (TCM). Both are responsible for the provision of pharmaceutical care with safe, effective, efficient and accountable medications for patients. Although Traditional Chinese Pharmacy is not a new subject, it faces a new medical environment and requires a transition. In recent years, Traditional Chinese Pharmacy is emerging as an independent discipline, largely due to global accepta Clinical Chinese Pharmacy, Pharmacist Education and Training, Curricular, Framework, Pharmaceutical Care, Traditional Chinese Medicine https://www.ijper.org/article/55/1/249-255 2026-04-13T05:23:58.627931+00:00 Appliance of the ICH Guidelines: Forced Degradation Studies on Abafungin and Development of Validated Stability Indicating Method by 1st Order Derivative Spectroscopy 2021-02-15 10.5530/ijper.55.1.28 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-249.pdf Background: The presented study is a stability indicating simple, precise and accurate 1st order UV derivative spectroscopic method that is being studied under the different stated International Council for Harmonization (ICH) Guidelines for the forced degradation and establishes a validated method for Abafungin and its main degradants in the active pharmaceutical ingredients (API) and the marketed formulations. Materials and Methods: Adhering to the ICH guidelines the analytical parameters viz. Abafungin, Forced degradation studies, 1st order derivative UV, spectroscopy, Method development and validation, Stress testing https://www.ijper.org/article/55/1/224-231 2026-04-13T05:23:58.627931+00:00 Bioactivity of Dodecanoic Acid Extracted from Geitlerinema sp. TRV57 2021-02-15 10.5530/ijper.55.1.25 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-224.pdf Aim/Background: Imbalance in oxidant and antioxidant leads to oxidant stress. Increased consumption of exogenous antioxidants helps in neutralizing the oxidant stress and thus protects the cells from oxidant stress. The study focused on the isolation of nutraceutical compound, dodecanoic acid from the marine cyanobacteria Geitlerinema sp. TRV57. Materials and Methods: Various solvents were used to extract the dodecanoic acid. The ability of the dodecanoic acid to neutralize the oxidant was studi Fatty acid, Cyanobacteria, Geitlerinema, Dodecanoic acid, Bioactivities https://www.ijper.org/article/55/1/21-25 2026-04-13T05:23:58.627931+00:00 An Overview on Pharmaceutical Tendering Process 2021-02-15 10.5530/ijper.55.1.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-21.pdf Objectives: World Health Organization (WHO) has implemented the Pharmaceutical tendering process for procuring the high-quality medicines from different firms to meet the needs of the countries which are having drug shortages. Materials and Methods: The main aim of the WHO is to get the quality products at low price which can be affordable by the patient. WHO constantly giving chance to different firms based on their qualification for tendering process. The pharmaceutical companies are inspected Tendering process, Procurement, GMP, Pre-qualification, Bidding https://www.ijper.org/article/55/1/126-135 2026-04-13T05:23:58.627931+00:00 Protective Effect of Natrium Diethyldithiocarbamate Trihydrate (NDDCT) on Lead Induced Neurodegeneration in Rats 2021-02-15 10.5530/ijper.55.1.15 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-126.pdf Aim: Lead is a powerful metal which induced neurotoxicity through the degradation of neurons in the body. Various neuronal changes have shown correlation with the generation of free radicals and oxidative stress. The present study was carried out to evaluate the neuroprotective activity of Natrium diethyl dithiocarbamate trihydrate (NDDCT) on lead induced neurodegeneration in rat’s model. Methods: We have evaluated the neuroprotective activity of NDDCT using Morris Water maze, Elevated plus maze Natrium diethyldithiocarbamate trihydrate (NDDCT), Neuroprotective, Biomarkers, Physical activity, Neurodegeneration, Cholinergic dysfunction https://www.ijper.org/article/55/1/198-204 2026-04-13T05:23:58.627931+00:00 Safety Evaluation of Syzygium jambolanum on the Development of Zebrafish Embryos 2021-02-15 10.5530/ijper.55.1.22 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-198.pdf Background: Gestational diabetes mellitus, a hyperglycaemic condition that develops at the time of pregnancy, causes approximately 7% of complications during pregnancies world wide. Syzygium jambolanum has been proved clinically for the management of diabetes mellitus and is being prescribed for the management of diabetes in pregnant women. Objectives: This study has been designed to evaluate the safety of Syzygium jambolanum mother tincture on the development of zebrafish embryos. Materials and Danio rerio, Development toxicity, Embryo toxicity, Syzygium jambolanum, Zebrafish https://www.ijper.org/article/55/1/174-183 2026-04-13T05:23:58.627931+00:00 Revisiting Therapeutic Potentials of Ethanolic Extract of Curcuma longa L. rhizomes to Evaluate wound Healing Progression upon Topical Application of its Ointment 2021-02-15 10.5530/ijper.55.1.19 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-174.pdf Background and Aim: The goodness of turmeric is claimed traditionally but providing proper scientific data will not only support the statements making it more evident but will also search for possible ways to enhance its potential. The present study aims to extract the bioactive components from turmeric rhizomes to appraise its ability as a therapeutic agent. Methodology: Ethanolic extract and its doses were prepared for antioxidant and cytotoxicity assay. In-vivo study of wound healing activity Cytotoxicity, Antioxidant, Wound healing, Collagen, Biomarkers, Histopathology https://www.ijper.org/article/55/1/184-189 2026-04-13T05:23:58.627931+00:00 Electroencephalogram Correlates the Role of Ashwagandha in Sleep and Memory Promoting Effect 2021-02-15 10.5530/ijper.55.1.20 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-184.pdf Background: Ashwagandha (Withania somnifera), a known traditional medicine used in Ayurveda system of medicine, native to the India. Poor quality sleep always looked as serious complaint as it disrupts sleep. The natural phytoconstituents present in the ashwagandha believed to be adaptogen that helps the body to adapt stress by normalizing or correcting through balancing immune and neuroendocrine system. The mechanism that enhances sleep quality in the presence of ashwagandha is still unknown. B Ashwagandha, Data acquisition, Delta, Memory, Sleep, Frequency https://www.ijper.org/article/55/1/70-76 2026-04-13T05:23:58.627931+00:00 Association between Personality Traits and Metacognition among Pharmacy Students: Implication for Pharmaceutical Education 2021-02-15 10.5530/ijper.55.1.10 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-70.pdf Background: The importance of pharmacy practitioners’ personality traits in their professional development and future patient-centered pharmaceutical care practice has been widely recognized. Metacognitive skills in critical thinking, self-directed learning as a critical part of pharmacy training has been emphasized in the new pharmacy education accreditation standard. Correlation between metacognition and personality has been demonstrated in patients with personality pathology. Objectives: This Personality, Metacognition, Association, Pharmacy students, Pharmaceutical, education https://www.ijper.org/article/55/1/232-239 2026-04-13T05:23:58.627931+00:00 Evaluation of Anti-urolithiatic Potential of Leaves of Alstonia scholaris and its Isolated Pentacyclic Triterpenoids in Ethylene Glycol-induced Renal Calculi Rat Model 2021-02-15 10.5530/ijper.55.1.26 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-232.pdf Introduction: Urolithiasis has afflicted human race since the days of yore. Conventional treatment acts only on associated ailments whereas pharmacologically active phytoconstituents derived from plants are reported to possess lithotriptic as well as anti-urolithiatic effect, thus herbal sources need to be scientifically explored. Present study was aimed to evaluate anti-urolithiatic potential of leaves of Alstonia scholaris and its isolated pentacyclic triterpenoids: lupeol and ursolic acid in Alstonia scholaris, Anti-inflammatory, Lupeol, Oxidative stress, Ursolic acid, Urolithiasis https://www.ijper.org/article/55/1/11-20 2026-04-27T07:23:47.725798+00:00 World Wide Uncharted Trajectory Outbreak Initiator: Coronavirus [COVID-19] Pathogenesis 2021-02-15 10.5530/ijper.55.1.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-11.pdf The Coronavirus (CoV) belongs to family of Coronaviridae, suborder Coronavirinae and Nidovirales order. CoV causes diseases in human with a just cold, cough and high fever symptoms simultaneously develops in to severe respiratory syndrome and ceases fatal. The source of virus is believed to be “Wet Market” in Wuhan, China. The source of the latest pandemic has not yet been identified exactly but the original host is expected to be bats and mammals, which are host of wide range of Zoonotic viruse WHO, Zoonosis, RNA, Receptor, Vaccine https://www.ijper.org/article/55/1/86-94 2026-04-27T07:27:22.063195+00:00 Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole 2021-02-15 10.5530/ijper.55.1.12 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-55-1-86.pdf Purpose: The main objective of present study is to evaluate the effect of various factors which have direct influence on the characteristic parameters of emulsomes formulation, so that optimized combination of factors can be find out which meet the high level of set desirability criteria. The present work is focused on the optimization of emulsomes formulation by applying Box-Behnken design (BBD) of experiment. Emulsomes are the modified form of emulsomes which consists of solid lipid core surro Box-Behnken Design (BBD), Emulsomes, Bifonazole, Phospholipid, Stearylamine, Tristearin https://www.ijper.org/article/54/1/31-45 2026-04-20T11:14:58.11953+00:00 Formulation and Evaluation of Solid Lipid Nanoparticle Containing Silver Sulfadiazine for Second and Third Degree Burn Wounds and its Suitable Analytical Method Development and Validation 2020-12-19 10.5530/ijper.54.1.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-31.pdf Aim: The main aim of this research work was to formulate, characterize and evaluate solid lipid nanoparticles containing Silver sulfadiazine. Materials and Methods: Solid lipid nanoparticles were prepared by hot homogenisation technique using Glycerol distearate, Tween 80 and Millipore water. These nanoparticles were then incorporated into a gel using Carbopol and trietnanolamine Optimised formulation was chosen according to its particle size, as it was for topical use. Various different evaluat Analytical method, Burn wounds, HPTLC, Silver sulfadiazine, Solid Lipid, Nanoparticles https://www.ijper.org/article/54/1/125-134 2026-04-20T11:14:13.470807+00:00 Bilateral Ovariectomy Decreases the Levels of Cyclic Nucleotides and Nuclear Phosphorylated Estrogen Receptor-Alpha in Memory-Sensitive Rat Brain Regions 2020-12-19 10.5530/ijper.54.1.15 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-125.pdf Aim/Background: The level of phosphorylated Estrogen Receptor alpha (ERα) in the nucleus was investigated in different memory-sensitive brain regions of estrogendeficient female rats. Further, the levels of cyclic nucleotides were estimated in those brain regions to draw a possible correlation with phosphorylated ERα signaling. Materials and Methods: Bilateral ovariectomy was performed on the first day of the experimental schedule of 60 days. Behavioural analysis was performed and various bioche Bilateral ovariectomy, Estrogen receptor alpha (ERα), Cyclic nucleotides, Ligand-independent mechanism, Cholinergic activity, Memory https://www.ijper.org/article/54/1/85-94 2026-04-20T11:14:32.812084+00:00 Antiproliferative Effect of Crude Venom from Conus virgo on Human Lung Cancer Cell Line and Toxicity Assessment on Adult Zebra Fish (Danio rerio) 2020-12-19 10.5530/ijper.54.1.10 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-85.pdf Background: For the past two decades, few conotoxins entered in clinical trial and some are available for pain relieving as well as for treatment of neurological disorders. Aim: The present investigation was made to elucidate the antiproliferative effect of crude venom from Conus virgo against human lung adenocarcinoma cells. Acute toxicity was determined on adult Zebra fish. Methods: Cytotoxicity was assessed by MTT assay where the DNA damage was carried out by DNA fragmentation method and the A549, Conus virgo, Cone snail, Zebra fish, Acute toxicity https://www.ijper.org/article/54/1/135-142 2026-04-20T11:14:06.961434+00:00 Preliminary Assessment of Acute and 28-Day Repeated Dose Oral Toxicity of a Newly Developed Herbal Mixture on Experimental Animal 2020-12-19 10.5530/ijper.54.1.16 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-135.pdf Objectives: Toxicity is an expression of being poisonous, indicating the state of adverse effects led by the interaction between toxicants and cells. The present study was designed to evaluate the acute oral toxicity study and 28 days repeated toxicity study of Herbal Mixture (HM) according to OECD guidelines. Materials and Methods: In acute oral toxicity study, Herbal mixture was administered at 2000mg/kg orally and animals were observed for toxic signs at 30 min, 1, 2 and 4 hr and thereafter o Acute oral toxicity, Sub acute toxicity, Herbal mixture, Haematology, Liver, function test, Histology https://www.ijper.org/article/54/1/55-67 2026-04-20T11:14:45.945197+00:00 Formulation and Evaluation of Cefixime Nanosuspension for the Enhancement of Oral Bioavailability by Solvent-Antisolvent Method and its Suitable Method Development 2020-12-19 10.5530/ijper.54.1.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-55.pdf Aim: The objective of the present study was to develop and evaluate cefixime nanosuspension to enhance its oral bioavailability. Materials and Methods: The method used was solvent/ antisolvent method in which methanol and Millipore water was used as solvent and antisolvent respectively. The surfactants used for the preparation were PVP K30 and HPMC K100 which was found to be compatible in the formulation. Compatibility of the drug and drug with its excipients was found out by FTIR studies. Chara Cefixime nanosuspension, Method development, HPTLC, Solvent/ Antisolvent, method, Validation https://www.ijper.org/article/54/1/8-16 2026-04-20T11:15:10.786458+00:00 Treatment of Osteoporosis: Current Scenario from a Research Perspective 2020-12-19 10.5530/ijper.54.1.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-8.pdf Osteoporosis is a condition of compromised bone quality and bone density increasing the chances of fracture. In osteoporotic bone, there is a mismatch between bone formation and resorption. The high probability in both women (33.33%) and males (20%) over the age of 50 worldwide to suffer a fracture draws attention to the importance of treatment of osteoporosis. The benefits of using bisphosphonates, the first line of therapy in osteoporosis lasts for 5 years. The other drugs are recommended for Abaloparatide, Romosozumab, Cathepsin K, Chloride channel 7, ɑvβ3 integrin https://www.ijper.org/article/54/1/22-30 2026-04-20T11:15:01.955469+00:00 Preconception of Pharmacy Students for the Inclusion of Entrepreneurship Curriculum in the PharmD Program 2020-12-19 10.5530/ijper.54.1.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-22.pdf Objectives: Pharmacy program offers many entrepreneurial opportunities in hospital, community and industrial sectors. Entrepreneurship is recognized, implemented and encouraged in many Universities around the world as a separate program to ease out the problems of unemployment. However, not all pharmacy students can afford to study dual programs to become an entrepreneur; hence, it would be worthwhile if it included in the PharmD curriculum. Methods: To assess the preconception of pharmacy stude PharmD, Entrepreneurship, Personality, Knowledge, Attitude, Self-employment https://www.ijper.org/article/54/1/46-54 2026-04-20T11:14:50.128179+00:00 Spray Dried Amorphous Form of Simvastatin: Preparation and Evaluation of the Buccal Tablet 2020-12-19 10.5530/ijper.54.1.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-46.pdf Background: The success of a drug primarily depends on its bioavailability. By enhancing the solubility and dissolution properties of drugs that are scarcely water soluble, significantly improves their bioavailability. Methods: This study was aimed to prepare a solid dispersion of the drug simvastatin that is a poorly water-soluble drug, through the spray drying technique. Solid dispersion carrier PVP, adsorbent Aerosil 200 and solvent dichloromethane were used to prepare solid dispersion. The p Spray drying, Crystalline, Simvastatin, Buccal tablet, Hydroxy propyl methyl, cellulose https://www.ijper.org/article/54/1/187-193 2026-04-20T11:13:31.763533+00:00 Development and Validation of Reverse-Phase High-Performance Liquid Chromatographic Method for Determination of Resveratrol in Human and Rat Plasma for Preclinical and Clinical Studies 2020-12-19 10.5530/ijper.54.1.22 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-187.pdf Aim: The aim of the study was to develop and validate a simple and precise reverse-phase High Performance Liquid Chromatography (RP-HPLC) method for quantitative analysis of trans-resveratrol in human and rat plasma. Methods: HPLC method was developed by using Phenomenex Luna C18 column (150 x 4.6 mm, 5 μm) and the optimized mobile phase comprised of acetonitrile/water in isocratic mode (30:70, v/v) with the flow rate of 1.0 mL/min. Trans-resveratrol was detected at a UV wavelength of 306 nm. De RP-HPLC, Trans resveratrol, Human plasma, Rat plasma, Storage stability, studies https://www.ijper.org/article/54/1/150-154 2026-04-20T11:13:57.528104+00:00 Method Development and Validation for Detection of Procaterol in Human Urine using Gas Chromatography-Tandem Mass Spectrometry 2020-12-19 10.5530/ijper.54.1.18 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-150.pdf Background: A simple, sensitive and accurate method for the determination of procaterol in human urine was developed and validated using Gas Chromatography coupled to tandem mass spectrometry (GC-MS/MS) as per the requirements of World Anti-Doping Agency (WADA) and ICH guidelines. Methodology: The sample processing includes deconjugation with enzymatic hydrolysis, Solid Phase Extraction (SPE) procedure using XAD2 column and Liquid-liquid Extraction (LLE) followed by the derivatisation using N-me Procaterol, Validation, ICH Guideline, GC-MS/MS, Doping control, WADA https://www.ijper.org/article/54/1/213-222 2026-04-20T11:13:14.69246+00:00 Natural and Synthetic Polymers Assisted Development of Lurasidone Hydrochloride Intranasal Mucoadhesive Microspheres 2020-12-19 10.5530/ijper.54.1.25 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-213.pdf Objectives: To avoid the first-pass metabolism of the drug (lurasidone HCl) and further improving its contact time with the nasal mucosa, intranasal mucoadhesive microspheres were developed by using natural (chitosan) and synthetic (Eudragit L 100) polymers by spray-drying method. The study aims to enhance the systemic drug absorption via the nasal membrane and to further evaluate the effect of polymers on the drug release profile. Methodology: The microspheres of each polymer were prepared in t Lurasidone, Intranasal, Mucoadhesive, Microsphere, Drug absorption https://www.ijper.org/article/54/1/206-212 2026-04-20T11:13:21.854548+00:00 Formulation and Evaluation of Antibacterial Topical Gel of Doxycycline Hyclate, Neem Oil and Tea Tree Oil 2020-12-19 10.5530/ijper.54.1.24 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-206.pdf Purpose: To formulate novel topical antibacterial gel containing Doxycycline Hyclate, Tea tree oil and Neem oil to evaluate their antibacterial activity. Methods: Formulation excipients were selected using Drug-excipients compatibility study. Prepared gel was subjected to various evaluation parameters like pH, viscosity, spreadability, homogeneity, drug content uniformity, in-vitro drug diffusion and antibacterial activity. Results: Prepared topical gel of doxycycline Hyclate was shown pH range Doxycycline Hyclate, Neem oil, Tea tree oil, Drug diffusion study, Antibacterial, activity https://www.ijper.org/article/54/1/1-7 2026-04-20T11:15:16.141371+00:00 Emerging Non-Pharmacological Therapies for Post-stroke Depression and its Future Aspects: A Review 2020-12-19 10.5530/ijper.54.1.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-1.pdf Post-Stroke Depression (PSD) is a psychiatric disorder associated with stroke which has an adverse effect on the cognitive function and survival. It usually develops in 40% of the stroke survivors within 3 months. We performed a thorough literature review using PsychInfo, PubMed, Science Direct and PLOS databases for the non-pharmacological treatment of PSD. Early rehabilitation and psychological therapies are effective in treating depression in PSD while physiotherapy and music therapy improves Caregiver, Cognitive Impairment, Non-Pharmacological Treatment, Post-, Stroke Depression, Quality of Life, Rehabilitation https://www.ijper.org/article/54/1/73-84 2026-04-20T11:14:36.484347+00:00 Direct Brain Targeted Nanostructured Lipid Carriers for Sustained Release of Schizophrenic Drug: Formulation, Characterization and Pharmacokinetic Studies 2020-12-19 10.5530/ijper.54.1.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-73.pdf Background: Systemic drug delivery in schizophrenia is a major challenge, owing to the Blood-brain Barrier (BBB) and P-glycoprotein related effects. Consequently, herein an attempt is made to systemically deliver the most desirable schizophrenia drug, Quetiapine Fumarate (QF) via non-invasive intranasal route using Nanostructured Lipid Carrier (NLC) approach. Materials and Methods: The desired QF loaded NLCs were developed using central composite statistical design and the developed formulations Nanostructured lipid carriers, Quetiapine fumarate, Schizophrenia, Brain, Targeting, Intranasal route https://www.ijper.org/article/54/1/166-174 2026-04-20T11:13:40.579464+00:00 Eco-friendly Derivative UV Spectrophotometric Methods for Simultaneous Determination of Diclofenac Sodium and Moxifloxacin in Laboratory Mixed Ophthalmic Preparation 2020-12-19 10.5530/ijper.54.1.20 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-166.pdf Background: Diclofenac Sodium (DCL) and Moxifloxacin HCl (MOX) were simultaneously used after cataract surgery to reduce the post-operative inflammation and to control infection respectively. Objectives: Three simple, accurate, eco-friendly and reproducible UV spectroscopic methods were established for concurrent determination of diclofenac sodium and moxifloxacin in ophthalmic preparation without prior separation. Methods: The first technique was established on the measurement of a peak amplitu Diclofenac sodium, Moxifloxacin, Ophthalmic preparation, Ratio derivative, spectroscopy, Validation https://www.ijper.org/article/54/1/114-124 2026-04-20T11:14:17.635214+00:00 Design of ALK Inhibitors for Non-Small Cell Lung Cancer – A Fragment Based Approach 2020-12-19 10.5530/ijper.54.1.14 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-114.pdf Background: The increasing cases of non-small cell lung cancer pose a relentless threat to human health. Therefore, using fragment-based drug discovery as the modus operandi, the present study aimed to design small molecule inhibitors for Anaplastic Lymphoma Kinase (ALK) positive Non-Small Cell Lung Cancer (NSCLC) and for its secondary mutation (F1174L). Materials and methods: A total of 12 ALK inhibitors (both FDA and clinical) reported in the literature was utilised in the present study to des ALK, SDM, I-Mutant, RIN, GLIDE, ADMET https://www.ijper.org/article/54/1/155-165 2026-04-20T11:13:45.0602+00:00 Development and Validation of HPTLC Method along with Forced Degradation Study for the Simultaneous Estimation of Azelastine Hydrochloride and Fluticasone Propionate in Nasal Spray Formulation using Design of Experiment Approach 2020-12-19 10.5530/ijper.54.1.19 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-155.pdf Objectives: The present research study focuses on the development of the highperformance thin layer chromatographic method using design of experiment approach for the simultaneous estimation of Azelastine hydrochloride and Fluticasone propionate along with forced degradation study. Methods: High performance thin layer chromatographic separation was performed on aluminium plates precoated with silica gel 60 F254 using toluene: chloroform: methanol (5: 4: 2, v/v/v) as optimized mobile phase. Azela Azelastine Hydrochloride, Fluticasone Propionate, HPTLC, Degradation, DoE, (Design of experiment), Validation https://www.ijper.org/article/54/1/194-205 2026-04-20T11:13:26.524721+00:00 Community Pharmacists’ Attitudes and Professional Practice in Relation to the Patient Safety Incidents 2020-12-19 10.5530/ijper.54.1.23 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-194.pdf Background: Medicines dispensing is an error-prone activity, therefore potentially jeopardizing patient safety. This study aimed to assess the community pharmacists’ attitudes towards the causes of dispensing errors and preventive measures, as well as their practice in incidents reporting. Materials and Methods: A cross-sectional survey was performed by distributing an adopted and validated questionnaire to a nationwide sample of community pharmacists in Serbia. The questionnaire included sectio Dispensing errors, Community pharmacy, Patient safety, Pharmacists’, attitudes, Risk management, Systems approach https://www.ijper.org/article/54/1/95-100 2026-04-20T11:14:28.937557+00:00 Protective Effect of Capsaicin against Doxorubicin Induced Cardiotoxicity in Experimental Rats 2020-12-19 10.5530/ijper.54.1.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-95.pdf Aim: The aim of the present study was to evaluate the Cardioprotective effect of Capsaicin (CAP) against Doxorubicin (DOX) induced cardiotoxicity in experimental rats. Methods: The 24 wistar rats were randomly divided into four groups (with equal numbers): Normal- 1% Dimethyl Sulfoxide (DMSO), DOX (15 mg/kg, i.p), CAP (10 mg/kg, p.o, alone) and CAP 10 mg/kg (in combination with DOX). Cardiotoxicity was induced in wistar rats by administering DOX with a cumulative dose of 15 mg/kg (i.p) for 2 wee Cardiotoxicity, Capsaicin, Doxorubicin, Electrocardiogram, LDH, GSH https://www.ijper.org/article/54/1/17-21 2026-04-20T11:15:05.874371+00:00 Calculating and Evaluating of the Achievements of Pharmaceutical Separation Engineering Course for Pharmaceutical Engineering Major Based on Engineering Education Certification 2020-12-19 10.5530/ijper.54.1.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-17.pdf Aim: This study aims to evaluate the efficiency of the achievement degree for engineering education certification, example as pharmaceutical separation engineering course. The calculating method of achievement degree about graduation requirement in engineering education certification in colleges and universities was introduced in this paper. Materials and Methods: A total 53 students were selected from the exam of pharmaceutical separation engineering course and the total score of the exam is 10 Professional certification, Graduation requirements, Achievement Degree, Excel https://www.ijper.org/article/54/1/68-72 2026-04-20T11:14:40.86067+00:00 Quantitative Estimation of Tabletability of Aceclofenac after Incorporation of Titanium Dioxide using Area under the Curve 2020-12-19 10.5530/ijper.54.1.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-68.pdf Background: Tablet manufacturing with direct compression is one of the leading industrial technique that consumes less time, labour and economic also. But the choice of excipients are critical in this case which will allow the drug to get compressed without granulation techniques. Purpose: Aceclofenac is a BCS class II non-steroidal anti-inflammatory drug, which exerts a low oral bioavailability because of low solubility in aqueous medium. The drug also suffers from compressibility and also show Aceclofenac, Tabletability, Titanium dioxide, Direct compression, Area under, the curve https://www.ijper.org/article/54/1/108-113 2026-04-20T11:14:21.523952+00:00 Effect of Vanillic Acid on Nerve Conduction Velocity in Chronic Constriction Injury Model of Neuropathy 2020-12-19 10.5530/ijper.54.1.13 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-108.pdf Background: Neuropathic Pain (NP) is less or symptomatically managed by presently available therapeutics. Therefore developing more effective drugs with minimum adverse effects is essential. Vanillic acid is phenolic secondary plant metabolite. Extensive research regarding phenolic acids with antioxidant, free radical scavenging and neuroprotective roles have been published. Objectives: The aim of this undertaken study was to evaluate the efficacy of vanillic acid (V.A.) to improve nerve conduct CCI, MNCV, Neuropathy, Gabapentin, Vanillic acid https://www.ijper.org/article/54/1/143-149 2026-04-20T11:14:01.673802+00:00 Ameliorative Potential of Allium cepa Lam. Leaves on Diabetes Induced and Chronic Constriction Injury Induced Neuropathic Pain in Experimental Rats 2020-12-19 10.5530/ijper.54.1.17 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-143.pdf Background: Neuropathy can be induced in rats by peripheral injuries, depending on compression of complete or a section of sciatic nerve and chemically by Streptozotocin (STZ). Materials and Methods: In the present study neuropathic pain were induced in rats by two methods, chronic constriction injury (surgical model) and STZ (40mg/kg/i.p.) induced diabetes (drug induced model). In both the models, behavioural as well as markers of oxidative stress were studied. Behavioural parameters were teste Allium cepa, Neuropathy, CCI, Oxidative stress, Sciatic nerve https://www.ijper.org/article/54/1/101-107 2026-04-20T11:14:25.13079+00:00 Immunomodulatory Potential of Leptadenia arborea in Immune-Challenged Rats 2020-12-19 10.5530/ijper.54.1.12 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-101.pdf Background: Plant-based remedies play a crucial role as powerful health aid worldwide. In recent years, the usage of complementary and alternative medicines has grown rapidly. The objective of the present study was to evaluate the immunomodulatory effects of methanolic extract of Leptadenia arborea leaves in BCG-immunized rats. Materials and Methods: L. arborea extract suspended in 1% carboxymethyl cellulose (CMC) was administered in three doses viz 50, 100 and 200 mg/kg, p.o. All animals were c Leptadenia arborea, Cell-mediated immunity, TH1 cytokines, TH2 cytokines, Immunomodulator https://www.ijper.org/article/54/1/175-186 2026-04-20T11:13:35.806401+00:00 Modelling Customers’ Buying Behaviour of Jan Aushadhi (Generic Medicines) 2020-12-19 10.5530/ijper.54.1.21 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-1-175.pdf Background: Jan Aushadhi, a scheme to make affordable generic drugs available to large sections of population was launched by the Government of India across the country in the year 2008. This exploratory research was conducted to study the attitude of customers (Bengaluru, India) towards acceptance of Jan Aushadhi and an attempt was made to model buying behavior in order to suggest mechanisms to speed up the acceptance. Materials and Methods: Data was collected using structured questionnaire. Z- Jan Aushadhi, Model, Customers’ attitude, Generic medicine, Segment, Exploratory Factor Analysis, Discriminant Analysis, Spearman’s Correlation, Z - test, Bengaluru, India https://www.ijper.org/article/54/4/954-962 2026-04-13T05:54:53.924935+00:00 Development and Evaluation of Flurbiprofen Loaded Transethosomes to Improve Transdermal Delivery 2020-12-15 10.5530/ijper.54.4.189 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-954.pdf Background: Flurbiprofen is prescribed for the symptomatic management of arthritis. Its oral administration leads to gastrointestinal damage and it has a short elimination halflife requiring multiple dosing. Transdermal drug delivery of flurbiprofen is an alternative route to bypass the stratum corneum layer of the skin. Nano-vesicular carriers can be used to overcome this problem as it increases the permeability and skin deposition of the drug and reduces dosing frequency. Materials and Methods Flurbiprofen, Transethosomes, Thin film hydration method, Edge activator, Soyaphosphotidylcholine https://www.ijper.org/article/54/4/1193-1206 2026-04-13T05:54:53.924935+00:00 Impacts of Digital Marketing on the Pharmacies Community in Saudi Arabia and Determining the Future Model of the Industry: A Cross-Sectional Questionnaire-based Study 2020-12-15 10.5530/ijper.54.4.174 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1193.pdf Background: Pharmaceutical and telemedicine industries are now finding ways in the Kingdom of Saudi Arabia by adopting innovative and successful business models along with groundbreaking strategies using digital online platforms particularly after the COVID-19 pandemic. Methods: The present study analyzes the impacts and frequencies of digital marketing technology usage among pharmacies and customers. A crosssection study was carried out using a non-repeated random sampling technique and a stand Digital Marketing, Pharmacy, Pandemic, Digitalization, Social Media https://www.ijper.org/article/54/4/983-990 2026-04-13T05:54:53.924935+00:00 Preparation and Characterization of Directly Compressible Spherical Agglomerates of Etoricoxib 2020-12-15 10.5530/ijper.54.4.192 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-983.pdf Aim: The current work contemplates formulation of spherical agglomerates of Etoricoxib, with a view to improve the flow properties, solubility and dissolution rate. Materials and Methods: Spherical agglomerates of etoricoxib were produced employing quasi emulsion solvent diffusion method using hydrophilic polymers like PVP K30 and PEG 6000. IR spectroscopy and Scanning Electron Microscopy along with physicochemical evaluations were used to characterize the agglomerates. Results: The optical micr Etoricoxib, Spherical, Agglomerates, Directly compressible, Flow properties, Rate of dissolution https://www.ijper.org/article/54/4/1174-1179 2026-04-13T05:54:53.924935+00:00 Development and Validation of Novel UV Spectrophotometric Method for the Determination of Evogliptin Tartarate in Pharmaceutical Dosage Form 2020-12-15 10.5530/ijper.54.4.214 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1174.pdf Aim: Development of a novel precise, selective and sensitive UV spectrophotometric method for the estimation of Evogliptin tartarate in bulk and tablet dosage forms. Materials and Methods: The estimation was carried out using deionized water as solvent and Quantitation was achieved using double beam UV spectrophotometer at 267 nm. Results: The Calibration curves of Evogliptin tartarate shows good linearity over the concentration range from 10-100 μg/mL with excellent correlation coefficient (R2= Evogliptin tartarate, UV-Spectrophotometry, Pharmaceutical formulations, Analytical Method Development, Validation https://www.ijper.org/article/54/4/1144-1152 2026-04-27T07:13:33.030065+00:00 Novel Stability Indicating RP-HPLC Method Development and Validation for Simultaneous Estimation of Alfuzosin and Dutasteride in Pharmaceutical Dosage Form 2020-12-15 10.5530/ijper.54.4.210 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1144.pdf Aim: The present study was to develop a simple, accurate and stable reverse phase liquid chromatographic method and validate in bulk drug and pharmaceutical dosage form for the simultaneous determination of Alfuzosin Hydrochloride (ALF) and Dutasteride (DUT). Materials and Methods: Chromatographic separation has been accomplished using an XTerra C18 Column (150×4.6mm, 5μm particle size) as the stationary phase, with an isocratic system of mobile phase Ammonium dihydrogen phosphate buffer (pH 6.5 Alfuzosin Hydrochloride, Dutasteride, RP-HPLC, Method development, Validation, Degradation https://www.ijper.org/article/54/4/946-953 2026-04-27T06:59:35.687142+00:00 Preparation of Ketoconazole Liposomes with an Ultrasonic and an Injection Method Using Vegetable Oils 2020-12-15 10.5530/ijper.54.4.188 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-946.pdf Introduction: Ketoconazole as antimycotic drug have a great impact in the treatment of many skin diseases. The toxicity of available ketoconazole in form of tablets, cream and shampoo is overcome by encapsulation in liposome structures which show potential benefits in aspect of biodegradability, increased stability and prolonged drug releasing. Objectives: The main objective of this study was to develop new formulations of ketoconazole liposomes characterized with satisfactory encapsulation effi Ketoconazole liposomes, Vegetable oil, SUV, LUV, MLV https://www.ijper.org/article/54/4/1098-1103 2026-04-13T05:54:53.924935+00:00 HPTLC Fingerprinting: A Tool for Simplified Analysis of Phenolics in Medicinal Plants 2020-12-15 10.5530/ijper.54.4.205 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1098.pdf Background: Phenolic compounds especially the flavonoids and tannins comprise one of the most significant classes of plant secondary metabolites. Aim: HPTLC is widely accepted by WHO and pharmacopoeia across the globe as an effective analytical method for the investigation of phenolics in herbal analyses. Materials and Methods: The methanolic extracts of Abrus precatorius L., Sapindus trifoliatus L. and Embelia ribes Burm. F. were developed on the HPTLC system to study the diversity of phenolic HPTLC, Flavonoids, Tannins, Abrus precatorius L, Sapindus trifoliatus L, Embelia ribes Burm. F https://www.ijper.org/article/54/4/1169-1173 2026-04-13T05:54:53.924935+00:00 Development of HPTLC Method for Estimation of Gallic Acid and Bergenin in Actaea acuminata Roots 2020-12-15 10.5530/ijper.54.4.213 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1169.pdf Introduction: The major drawback associated with herbal drugs is to get their reproducible therapeutic efficacy. Standardization of herbal drugs with marker compounds seems to be a viable solution to achieve their consistent therapeutic effects. Objectives: Standardization of roots of Actaea acuminata, a traditional medicinally promising plant, using selected marker compounds. Methods: A. acuminata was standardized by estimating the content of gallic acid and bergenin in its roots using HPTLC sy Actaea acuminata, Bergenin, Gallic acid, HPTLC, Standardization https://www.ijper.org/article/54/4/1024-1030 2026-04-13T05:54:53.924935+00:00 Influence of Ketogenic Diet and Phenytoin Sodium on Isoniazid Induced Epilepsy in Wistar Rats 2020-12-15 10.5530/ijper.54.4.196 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1024.pdf Aim: The current research was set up to estimate the influence of ketogenic diet in combination with phenytoin sodium on isoniazid induced epilepsy in rats. Methods: In this work 30 rats were used with weight range of 150-200gms were selected and divided into five groups. Group -1(Positive control), Group – II (Negative control), Group – III (Standard), Group – IV (Ketogenic diet), Group – V (Ketogenic diet + Standard). The doses of isoniazid, phenytoin sodium, ketogenic diet were selected and t Epilepsy, Ketone diet, Isoniazid, Phenytoin, GABA https://www.ijper.org/article/54/4/875-880 2026-04-13T05:54:53.924935+00:00 The Need for Simulated Patient Method Implementation in Pharmaceutical Education in Poland 2020-12-15 10.5530/ijper.54.4.180 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-875.pdf Background: Changing societal expectations towards pharmacy graduates and increased focus on communication skills, interprofessional collaboration and pharmaceutical care in their curricula, point out necessity of using new educational techniques to introduce pharmacy students to more practical elements of their future profession. Purposes: The aim of presented study was to introduce and discuss the simulated patient method (SP-method) and indicate potential areas of its implementation into phar Simulated patients, Pharmacy students, Pharmaceutical education, Pharmaceutical curriculum, Practical skills https://www.ijper.org/article/54/4/935-945 2026-04-27T06:59:06.621334+00:00 Development of Donepezil Hydrochloride Loaded Gellan Gum Based Nasal Mucoadhesive Microspheres by Spray Drying Method 2020-12-15 10.5530/ijper.54.4.187 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-935.pdf Objectives: The aim of present study was the formulation of donepezil hydrochloride loaded polymeric mucoadhesive microspheres for delivery via nasal route to increase the residence time and absorption of drug from the nasal mucosa. Methodologies: The microspheres were formulated by conventional spray drying technique by using gellan gum as a mucoadhesive polymer. A 32 full factorial design was utilized with polymer concentration (X1) and liquid feed flow rate (X2) as independent variables in fo Mucoadhesion, Intranasal, Microsphere, Donepezil hydrochloride, Spray, drying https://www.ijper.org/article/54/4/881-887 2026-04-13T05:54:53.924935+00:00 Training in Professional Pharmacy Services through Educational Videos 2020-12-15 10.5530/ijper.54.4.181 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-881.pdf Objectives: Pharmaceutical Care is a subject within the Pharmacy degree that can not only be taught using theoretical frameworks but also requires new teaching tools, like a simulated educational video. The objective of this study is to produce simulated patientbased videos as a supplementary teaching tool to deepen the understanding and knowledge of Professional Pharmacy Services. Design: Several videos based on simulated patient cases of the most prevalent Professional Pharmacy Services (medic Pharmaceutical care, Teaching video, Master, Pharmacy Services, Education https://www.ijper.org/article/54/4/896-904 2026-04-27T06:56:37.552656+00:00 An Approach to the Evaluation of Program Outcomes and Consideration of Activities beyond Curriculum for Improvement of Program Outcome Attainment 2020-12-15 10.5530/ijper.54.4.183 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-896.pdf Current global scenario demands outcome based education to develop graduates with universal acceptability. Program Outcomes (POs) laid by NBA (Table 1) are the assessable components indicative of graduate potential to demonstrate competencies to practice at appropriate levels. Program Outcomes (PO) can be defined and calculated by assessment of various Course Outcomes (CO) which can further be evaluated from Learning Outcomes (LOs). Blooms Taxonomy classifies LOs into the cognitive, affective an Blooms Taxonomy, Program Outcomes, Graduate Attributes, Program, Educational Objectives, Co-curricular, Extracurricular https://www.ijper.org/article/54/4/971-982 2026-04-13T05:54:53.924935+00:00 Formulation and Evaluation of Phanera variegata Linn. Mucilage as a Pharmaceutical Binder in Solid Dosage Form 2020-12-15 10.5530/ijper.54.4.191 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-971.pdf Objectives: The present study is aimed to isolate, evaluate the mucilage obtained from the leaves of Kachnar (Phanera variegata) and to compare the binding efficacy of the isolated mucilage with acacia gum. Methods: Extraction and isolation of mucilages from the leaves of Phanera variegata were carried out by the maceration method. The isolated mucilage was analyzed for phytochemical, microbial andvarious physico-chemical properties for acceptability as a novel excipient for the formulation of t Paracetamol, Phanera variegata, Mucilage, Maceration, Formulation, in vitro, dissolution https://www.ijper.org/article/54/4/1184-1192 2026-04-13T05:54:53.924935+00:00 Community Pharmacist and Clinical Pharmacist Interventions using MMAS-8, FACIT, SF-12 among Pulmonary TB Patients Receiving Anti-TB Drugs from Urban Community Pharmacies, South India 2020-12-15 10.5530/ijper.54.4.216 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1184.pdf Aim and Objectives: To determine the professional interaction between community pharmacist and clinical pharmacist during the treatment of pulmonary tuberculosis (TB) patients at urban community pharmacy. Methods: A randomized controlled study was conducted in the urban area of Belagavi city, India. Community pharmacist and clinical pharmacist intervention using Developed KAP (Knowledge, Attitude and practice) questionnaires, Morisky Medication Adherence Scale (MMAS-8), FACIT- Satisfaction with Community Pharmacists, Clinical Pharmacists, Pulmonary Tuberculosis, Quality of life, Medication Adherence, Knowledge, Attitude and Practice (KAP) https://www.ijper.org/article/54/4/991-998 2026-04-13T05:54:53.924935+00:00 Investigation of Effect of Phytoconstituents Aloe Emodin and Quercetin on Bioavailability of Albendazole 2020-12-15 10.5530/ijper.54.4.193 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-991.pdf Background/Aim: Albendazole is a drug with benzimidazole nucleus and is poorly absorbed from the gastrointestinal tract due to its low aqueous solubility. The objective of present work was to study the effect of two phytoconstituents aloe emodin and quercetin on the bioavailability of albendazole. Materials and Methods: Estimation was done through UV spectroscopy and HPLC analysis using different concentration of both the phytoconstituents. In-vivo study was conducted to investigate the pharmaco Albendazole, Aloe emodin, Quercetin, Bioavailability, Pharmacokinetics https://www.ijper.org/article/54/4/999-1006 2026-04-13T05:54:53.924935+00:00 Insulin Resistance Modulation with Lifestyle Modification- Proof-of-Concept Study in Rats 2020-12-15 10.5530/ijper.54.4.173 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-999.pdf Purpose: Fatigue, a physical and/or mental exhaustion is a common symptom of diabetes. Easy fatigability is not limited to uncontrolled diabetes however is comorbid with psychological, medical, metabolic, and chronic complications like insulin-resistance, glucose intolerance, and obesity. Methods: We analyzed the effect of lifestyle modification involving physical exercise and intake of omega 3 fatty acid-rich fish oil on insulin resistance and diabetic fatigue. For the same, diabetes was induce Insulin, Fatigue, Diabetes, Fish Oil, Exercise https://www.ijper.org/article/54/4/1031-1038 2026-04-13T05:54:53.924935+00:00 In silico Evaluation on the Inhibition Efficacy of Five Antivirals on SARS-CoV-2 Protease (COVID-19) 2020-12-15 10.5530/ijper.54.4.197 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1031.pdf Background: All over the world rigorous research attempts are going on to find a remedy for the spreading and prevention of the dreadful pandemic of 21st century, the Coronavirus Disease (COVID-19). To discover an effective drug for curing and a preventive vaccine against this disease it will take more than one year. According to some medical practitioners certain antivirals which are used for other diseases can cure COVID-19. Aim: In the present investigation, five antivirals claiming to be eff COVID-19, Docking, Inhibitor, Protease, Lopinavir, Ritonavir https://www.ijper.org/article/54/4/1062-1071 2026-04-13T05:54:53.924935+00:00 Xanthine Oxidase and Lipid Peroxidation Inhibition of Taiwan Folkloric Medicine Factors Affecting Rhus semialata var. Roxburghiana Activities against Xanthine Oxidase and Ferrous Iron-induced Lipid Peroxidation on Mice Liver Mitochondria 2020-12-15 10.5530/ijper.54.4.201 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1062.pdf Background: Gout, a disease characterized by recurrent inflammatory for urate deposit from overactive xanthine oxidase, is common among Taiwanese. Rhus semialata var. roxburghiana (RSR) grows wildly in Central Mountain of Taiwan and used by aboriginal Taiwanese as traditional medicine for gout and hepatitis. Methods: In this study, the factors such as variations in RSR extracts in terms of geographical sources, aerial parts and extraction solvents were investigated for antioxidant capabilities, Rhus semialata var. Roxburghiana extracts, Geographical source, Xanthine, oxidase inhibitor, Free radical scavenging, Liver mitochondria LPO inhibitor https://www.ijper.org/article/54/4/1072-1079 2026-04-13T05:54:53.924935+00:00 Standardization of Trigonella foenum-graecum L. Seeds: A Quality by Design Approach 2020-12-15 10.5530/ijper.54.4.202 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1072.pdf Aim: To standardize Trigonella foenum-graecum L. Seeds by developing QbD based HPLC method for identification and quantification of trigonelline in T. foenum graecum L. seeds, along with evaluation of various quality control parameters. Methods: The Analytical Target Profile and Critical Quality Attributes were determined followed by optimization of HPLC method by using 22 factorial design for designing the experiments for selected independent factors. Method Operable Design Region was developed Quality by Design, Trigonella foenum-graecum L, Trigonelline, Standardization, HPLC https://www.ijper.org/article/54/4/1080-1088 2026-04-13T05:54:53.924935+00:00 Evaluation of Hepatoprotective Effect of a Polyherbal Megakutki against Paracetamol-Induced Hepatotoxicity 2020-12-15 10.5530/ijper.54.4.203 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1080.pdf Background: Megakutki® (MK) is a polyherbal preparation of 11 standardized extracts that are individually proven for hepatoprotection scientifically. Aim: Study evaluated MK’s hepatoprotective potential against paracetamol (PCM) in in-vitro on Hep G2 cells using cell viability, cell cycle analysis and apoptotic studies and in in-vivo in Wistar rats using liver function tests, histological and DNA fragmentation study. Materials and Methods: In in-vitro studies, IC50 (50% inhibition in viability) Megakutki, Paracetamol, Hepatoprotection, Cell viability, Hep G2 https://www.ijper.org/article/54/4/1133-1143 2026-04-13T05:54:53.924935+00:00 An in-depth Study of the Concept of Chirality in Organic and Pharmaceutical Chemistry: Using Crystal Structure Data with 3D Visualization Software 2020-12-15 10.5530/ijper.54.4.209 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1133.pdf Background: Chirality is an essential feature of life and a universal phenomenon in nature, chirality in chemistry and biochemistry is closely related to biological, spectroscopic and physical properties. The concept of chirality also has important applications in pharmaceutical chemistry. Objectives: This article aims to introduce how crystal structure data can be used in 3D visualization software to deepen students’ understanding of the concept of chirality in organic and pharmaceutical chemis Crystal structure data, Chirality, Pharmaceutical chemistry, Educational, informatization, Instructional tool, Reform in education https://www.ijper.org/article/54/4/915-920 2026-04-13T05:54:53.924935+00:00 Promoting Student-Run Online Class Review Activities as Effective Cooperative Learning 2020-12-15 10.5530/ijper.54.4.185 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-915.pdf Objectives: The aim of this work was to enable students to set up and organize for themselves online review activities after class. Materials and Methods: Students worked as groups to create short notes and quizzes that covered the topics from a lecture course and shared them by using free online tools. To provide support and motivation, the instructors offered advice on how to organize the activities and effectively create quizzes and notes. Prizes were awarded to students who won the popular v Student-run, Review activity, Online, Quiz, Notes, Cooperative learning https://www.ijper.org/article/54/4/905-914 2026-04-13T05:54:53.924935+00:00 Implementation of an Innovative Learning Resource with Project to Facilitate Active Learning to Improve Students’ Performance on Chemistry 2020-12-15 10.5530/ijper.54.4.184 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-905.pdf Background: The provision of suitable and comprehensive learning resources concedes to be an effective strategy to create a serviceable learning process to achieve the competencies needed by students. Objectives: This research aims to provide an innovative learning resource with projects to facilitate active learning to improve student performance in chemistry. Methods: This research conducted by developing of chemistry learning package through the integration of projects, media and multimedia i Innovative learning, Project based learning, Students performance, Active, learning, Organic chemistry https://www.ijper.org/article/54/4/963-970 2026-04-13T05:54:53.924935+00:00 Mucoadhesive in-situ Gel Formulation for Vaginal Delivery of Tenofovir Disoproxil Fumarate 2020-12-15 10.5530/ijper.54.4.190 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-963.pdf Introduction: Tenofovir disoproxil fumarate is an anti-retroviral medicine which belongs to microbicides class being formulated for a woman instigated technique of prevention of the human immunodeficiency virus infection. The objective of the present investigation is to prepare thermosensitive mucoadhesive in-situ vaginal gel of Tenofovir disoproxil fumarate that can present pre-exposure prophylaxis against human immunodeficiency virus in addition to providing excellent spreading as well as coat Antiretroviral drug, Thermosensitive, Mucoadhesive, in-situ gel, Non-irritant https://www.ijper.org/article/54/4/1039-1045 2026-04-13T05:54:53.924935+00:00 Asarone and Metformin Modulates the Oxidant- Antioxidant Imbalance on Experimentally Induced Hepatocellular Carcinoma during Diabetic Condition 2020-12-15 10.5530/ijper.54.4.198 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1039.pdf Aim: The aim of the present study was planned to investigate the efficacy of asarone and metformin HCl as an antioxidant on experimentally induced diabetic-hepatocellular carcinoma (HCC) condition in male Wistar rats. Methods: Diabetes was induced in experimental rats by single intraperitoneal injection of streptozotocin (STZ; 55 mg/kg b.w.). Following two weeks of STZ injection, the diabetic-HCC condition was simulated in the rats with a single intraperitoneal dose of diethylnitrosamine (DEN; 2 Asarone, Diethylnitrosamine, Metformin, Oxidative stress, Streptozotocin https://www.ijper.org/article/54/4/1056-1061 2026-04-27T07:06:23.106658+00:00 Antiangiogenic Potential of Levetiracetam by Blocking N-type Voltage Gated Calcium Channels 2020-12-15 10.5530/ijper.54.4.200 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1056.pdf Objectives: Angiogenesis is generation of micro vessels. These ion channels on endothelium play vital functions in cell proliferation, migration, cell volume expansion and in related angiogenesis. Our study aims to evaluate the antiangiogenic capability of Levetiracetam, a N-type voltage gated calcium channel blocker. Methods: Anti-angiogenic activity was evaluated by MTT cell viability assay, Morphological screening assay, Zebra fish caudal fin assay and Zebra fish embryo assay using different Angiogenesis, Levetiracetam, Calcium channels, Cell migration, Neovascularisation https://www.ijper.org/article/54/4/1007-1015 2026-04-27T07:02:57.471962+00:00 Development of Solid Dispersions of Clopidogrel using Innate Excipient: Synergistic Antiplatelet Activity 2020-12-15 10.5530/ijper.54.4.194 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1007.pdf Aim: The present study encompasses on formulation and evaluation of solid dispersion of Clopidogrel, Class II drug-using pectin extracted from mango peel. Materials and Methods: Pectin was extracted from full-grown mango peel grown in the Kangra region. Solid dispersions were prepared using kneading, hot fusion method and solvent wetting method and the solvent wetting method were gauged and optimized. The prepared solid dispersions were subjected to solubility analysis and selected optimized for Pectin, Solid Dispersion, Clopidogrel, DDSolver, Mean Dissolution Time https://www.ijper.org/article/54/4/847-857 2026-04-13T05:54:53.924935+00:00 An Outbreak of Severe Acute Respiratory Syndrome-2019 (COVID-19): A Major Health Concern 2020-12-15 10.5530/ijper.54.4.177 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-847.pdf In Wuhan City, the province of Hubei, China, there appeared an unusual epidemic of pneumonia of uncertain ethology in December 2019. A novel coronavirus was identified by the World Health Organisation (WHO) as the triggering agent and subsequently named COVID-19. Considered a relative of SARS, which infected the lower respiratory tract and manifested in people as pneumonia, COVID-19 is the product of a beta-Corona virus called SARS-COV-2. The frequency of COVID-19 infection continue to increase, COVID-19, Pandemic, Outbreak, Lockdown, Pollution, Nutrition https://www.ijper.org/article/54/4/888-895 2026-04-13T05:54:53.924935+00:00 Drug Development Chain and Professional Curriculum Chain Integrated Pharmacy Courses 2020-12-15 10.5530/ijper.54.4.182 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-888.pdf Background: The disjointed problem of pharmacy education training and research in the pharmaceutical industry has become increasingly prominent, restricting the "professional idea or competency transfusion" ability from pharmacy colleges and universities to the pharmaceutical industry in China. This study we proposed an integrated double-chain consisting of the "professional curriculum chain" and the "drug development chain" for successful solving this problem. Objectives: To develop the combina Pharmacy, Education, Double-chain integration, Drug development chain, Professional curriculum chain, Curriculum reform https://www.ijper.org/article/54/4/1153-1158 2026-04-27T07:14:00.425406+00:00 New Method for the in vivo Estimation of Fluvastatin and its Application for Pharmacokinetic Studies in Rabbit 2020-12-15 10.5530/ijper.54.4.211 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1153.pdf Aim: The study was aimed to conduct a pharmacokinetic evaluation of Fluvastatin in rabbit plasma using a sensitive HPLC method. Materials and Methods: The plasma samples were assayed by Waters alliance e-2695 HPLC instrument using symmetry C18 column (150x4.6mm, 3.5 μ) under isocratic condition. Here the buffer was 0.1% ortho phosphoric acid. Mobile phase used was acetonitrile and 0.1% ortho phosphoric acid in 50:50 v/v with a flow rate of 1 ml/min. The eluent was monitored at 224 nm for measure RP-HPLC, Fluvastatin, Rabbit Plasma, Linearity, Accuracy, Pharmacokinetics https://www.ijper.org/article/54/4/843-846 2026-04-27T06:43:05.746818+00:00 Artificial Intelligence: A New Paradigm for Pharmaceutical Applications in Formulations Development 2020-12-15 10.5530/ijper.54.4.176 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-843.pdf Artificial Intelligence is a branch of engineering that specializes in developing intelligent machines. The utilization of artificial intelligence in pharmaceutical technology has elevated over the years. Over the beyond few years, the sector of artificial intelligence has moved from largely theoretical research to real-international applications. Machine learning is an application of artificial intelligence that gives systems the capacity to automated learn and enhance from experience without b Artificial intelligence, Pharmaceutical technology, Drug development, Health, care, Engineering https://www.ijper.org/article/54/4/1046-1055 2026-04-13T05:54:53.924935+00:00 Effect of Normosil Probiotic Supplementation on the Growth Performance and Blood Parameters of Broiler Chickens 2020-12-15 10.5530/ijper.54.4.199 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1046.pdf Purpose: This study was aimed to investigate the effects of probiotic “Normosil” containing a mixture of living cultures of Lactobacillus and Enterococcus strains at a concentration of 1×106 and 1×107 CFU/mL was assessed. Materials and Methods: Effect of Normosil on the growth performance, hematological and biochemical factors of Arbor Acres broilers from a day-old to 42-day old (n= 175, 1 control + 4 experimental groups) daily and periodically. Results: Results showed that Normosil (1×106 CFU/m Probiotics, Biochemical parameters, ArborAcres cross broilers, Normosil, Hematological parameters, Albumin-globulin coefficient, Nutrient digestibility https://www.ijper.org/article/54/4/858-864 2026-04-13T05:54:53.924935+00:00 Pharmaceutical and Biotechnological Importance of Actinobacterial Products 2020-12-15 10.5530/ijper.54.4.178 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-858.pdf Many compounds produced by marine microbes possess significant pharmaceutical applications. Actinobacteria are one among the microbes producing a variety of antibiotics. Apart from antibiotics, it also produces many novel enzymes and important pharmaceutical products. Actinobacteria serves as a reservoir of antibiotics and novel chemical compounds and it contributes 80% of antibiotics available in the market. It was continuously been explored for novel bioactive compounds and new chemical entiti Actinobacteria, Metabolites, Antibiotics, Enzymes, Biosurfactants, Dye, degradation https://www.ijper.org/article/54/4/1159-1168 2026-04-13T05:54:53.924935+00:00 Development of Validated Stability-indicating RP-HPLC Method for Determination of Novel Directly Acting Antiviral agent and Characterization of its Degradants by LC–ESI–MS 2020-12-15 10.5530/ijper.54.4.212 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1159.pdf Aim: The current study was performed to develop and validate stability indicating high performance liquid chromatography method (RP-HPLC) for determination of ledipasvir (LPR); to identify and characterize its major degradants by liquid chromatographic– tandem mass spectrometric method (LC-ESI-MS). Materials and Methods: The method was developed using reverse phase gradient elution and validated for standard ICH parameters. The optimized mobile phase comprised of acetonitrile:water with 0.2 % fo RP-HPLC, LC-ESI-MS, Ledipasvir, Stability indicating ICH method, Validation, Degradation pathway https://www.ijper.org/article/54/4/1180-1183 2026-04-13T05:54:53.924935+00:00 Estimation of the Probability to Target Attainment to the Pharmacokinetic/ Pharmacodynamic Index of Ertapenem in Elderly Inpatients 2020-12-15 10.5530/ijper.54.4.215 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1180.pdf Background: Infectious diseases are one of the most causes of hospitalization and death in adults in the elderly and this population is prone to develop complications and pharmacokinetic/pharmacodynamic changes. Objectives: To estimate the probability to target attainment (PTA) to the pharmacokinetic/pharmacodynamic (PK/ PD) index of ertapenem for older adults hospitalized in a medical ward. Materials and Methods: In a prospective and observational analysis, free drug concentrations of ertapenem Elderly, Ertapenem, Pharmacokinetics, Probability to target attainment, PK/, PD index https://www.ijper.org/article/54/4/1121-1132 2026-04-13T05:54:53.924935+00:00 Synthesis, in-silico Studies and Evaluation of Anticancer Activity of Some Novel Benzothiazole Substituted 4-Thiazolidinones 2020-12-15 10.5530/ijper.54.4.208 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1121.pdf Background: Cancer is one of the leading diseases associated with the high degree of mortality. In current scenario chemotherapy is the major treatment for cancer and it still has few limitations. The continuous seek for highly effective and safe anticancer agents is the one of the major goal for medicinal chemists. Objectives: In the present work, the hybrid molecule i.e benzothiazole substituted 4-thiazolidinone has been synthesized and evaluated for anticancer activity. Methods: A series of n Benzothiazole, 4-Thiazolidinone, Anticancer, In silico, Docking https://www.ijper.org/article/54/4/865-874 2026-04-27T06:45:51.467162+00:00 Using Chloroquine and Hydroxychloroquine in the Treatment of COVID-19: Does It Make Sense? 2020-12-15 10.5530/ijper.54.4.179 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-865.pdf The severe acute respiratory syndrome caused by the new coronavirus SARS-Cov-2 (COVID-19) has quickly turned into a pandemic, infecting more than 10 million people and causing more than 500,000 deaths worldwide. The absence of an effective treatment against this disease has led several researchers to investigate the possibility of redirecting drugs already known to be effective against other diseases in the treatment of COVID-19, among them the antimalarial drugs chloroquine and hydroxychloroqui COVID-19, SARS-Cov-2, Coronavirus, Chloroquine, Hydroxychloroquine, antiviral activity https://www.ijper.org/article/54/4/1089-1097 2026-04-13T05:54:53.924935+00:00 Neuroprotective effect of 1, 3-β-glucan-curcumin mixing (Bioglucur) on Alzheimer Disease Induced in Mice by Aluminium Toxicity 2020-12-15 10.5530/ijper.54.4.204 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1089.pdf Aim: The aim of this study was to evaluate the neuroprotective effect of oral administration of acomplex of curcumin with 1,3-β-glucan extracted from Vietnamese mushrooms named Bioglucur to increase drug delivery efficiency and biological effectin Alzheimer’s model mice. Materials and Methods: Alzheimer’s disease was induced in mice and treated in parallel by Bioglucur. Results: Results obtained show that the Bioglucur improves impart mental concentration and memory and decrease anxiety thus the Alzheimer’s disease, Medicinal Mushroom, Curcumin, Bioglucur, Mice https://www.ijper.org/article/54/4/921-934 2026-04-13T05:54:53.924935+00:00 In-situ Gelling System for Mucoadhesive Site- Specific Drug Delivery for Treatment of Recurrent Vaginal Candidiasis 2020-12-15 10.5530/ijper.54.4.186 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-921.pdf Objectives: The purpose of this work was to design and evaluate bio adhesive films for effective treatment against vaginal candidiasis. Fluconazole, a bis tri-azole agent inhibits ergosterol synthesis leading to the disruption of fungal membrane for use as an antifungal agent. The pharmacokinetic profile of fluconazole reveals minimal metabolization, low protein binding and is largely excreted in the urine. Methods: Bioadhesive films were prepared by the solvent evaporation technique. The excipi Fluconazole, Vaginal film, Mucoadhesive, Vaginal drug delivery, Vulvovaginal candidiasis https://www.ijper.org/article/54/4/835-842 2026-04-27T06:41:49.853322+00:00 Reduced Pharma Supply Chain in COVID-19: Measures to Reduce India’s Reliance for Active Pharmaceutical Ingredients on China and other Countries 2020-12-15 10.5530/ijper.54.4.175 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-835.pdf India, which is called the “world of pharmacy” for being a top supplier of medicines in several countries, can depend on other countries for Active Pharmaceutical Ingredients (API) and other raw materials. Although India is one of the major suppliers of high-quality medicines in several countries, the Indian pharmaceutical industry is highly dependent on China and other countries in terms of raw materials (including the production of essential medicines such as Crocin). These raw materials are c Active Pharmaceutical Ingredients, Imports of API, Imports from China, COVID-19, Bulk drugs, Opportunity for India https://www.ijper.org/article/54/4/1016-1023 2026-04-27T07:04:15.475973+00:00 Evaluation of Gelling Behavior of Natural Gums and their Formulation Prospects 2020-12-15 10.5530/ijper.54.4.195 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1016.pdf Purpose: Gums and polymers can be found abundantly in the nature from various plants, microbial and marine sources. Their physical and functional characteristics can be customized according to its application in product development. The purpose of this study is to determine the potentiality of natural gums obtained from plant based sources in development of gel formulation and its comparison with the commercially used polymers viz. Carbapol 934, Carboxy Methyl Cellulose, Xanthan, Sodium Alginate Eco-friendly, Gelling agents, Gel Formulations, Muco-adhesiveness, Antimicrobial activity https://www.ijper.org/article/54/4/1109-1120 2026-04-27T07:12:05.693021+00:00 Antioxidant and Anti-inflammatory Activity Screening of Lasia spinosa Rhizome and its Validation using a Computational Simulation Approach 2020-12-15 10.5530/ijper.54.4.207 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1109.pdf Background: The present work assesses the antioxidant and anti-inflammatory effect of Lasia spinosa rhizome extracts on in-vitro and in-vivo models compiled through molecular docking study of plant-steemed phytocompounds with specific targets. Materials and Methods: In this study, Lasia spinosa rhizome was subjected to extraction using petroleum ether, ethyl acetate and methanol and the extracts were analyzed by GC-MS. Antioxidant was assessed using in-vitro methods such as DPPH scavenging activ Lasia spinosa, Antioxidant, Anti-inflammatory, In silico, Auto dock https://www.ijper.org/article/54/4/1104-1108 2026-04-27T07:11:31.569309+00:00 Phytochemical Investigation, TLC-HPLC Fingerprinting and Antioxidant Activity of Cissus repanda Roots 2020-12-15 10.5530/ijper.54.4.206 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-4-1104.pdf Aim: To perform phytochemical screening, TLC, HPLC fingerprinting and antioxidant assay of Aqueous, Aqueous-Ethanolic and 95% Ethanolic extracts of Cissus repanda roots. Methods: Aqueous, Aqueous-Ethanolic and 95% Ethanolic extracts of Cissus repanda roots were subjected to preliminary phytochemical analysis. TLC patterns of all the three extracts were developed on the basis of phytochemical analysis results. All extracts were subjected to HPLC fingerprinting. The antioxidant potential of all th Antioxidant assay, Cissus repanda, HPLC, Phytochemical analysis, Thin, Layer Chromatography https://www.ijper.org/article/54/3s/s529-s536 2026-04-27T05:27:49.772329+00:00 Ellagic Acid Protects against Activation of Microglia by Inhibiting MAPKs and NF-κB Signalling 2020-10-18 10.5530/ijper.54.3s.152 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-529.pdf Context: One of the hallmarks of neurodegenerative diseases is dysregulation of microglia resulting in neuroinflammation. Neuroinflammation is related to multiple neurodegenerative disorders, including stroke and Alzheimer’s disease. Ellagic acid (EA) possesses antiapoptotic activity, anti-inflammatory, and antioxidant properties. It is most commonly found in fruits and nuts. EA has been linked to neuronal protection particularly through its anti-inflammatory and antioxidant actions. For example Neuroinflammation, Anti-inflammation, Ellagic acid, Microglia, NF-κB, MAPKs https://www.ijper.org/article/54/3s/s485-s491 2026-04-27T05:24:15.180516+00:00 Effect of Plasticizer on Delivery of Valsartan from Tamarind Gel Based Transdermal Film Formulation 2020-10-18 10.5530/ijper.54.3s.147 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-485.pdf Purpose: The present investigation was undertaken to study the effect of different plasticizers on the drug delivery pattern of valsartan from tamarind gum based hydroxypropyl methylcellulose (HPMC K100) transdermal film formulation. Methods: The matrix films of valsartan were prepared by casting solvent evaporation method using triethanolamine, propylene glycol, dimethyl sulphoxide, polyethylene glycol 400 or polyethylene glycol 600 as plasticizers. Physicochemical characteristics have also bee Valsartan, Hydrophilic plasticizer, Tamarind gum, Transdermal film, ex-vivo, permeation https://www.ijper.org/article/54/3s/s390-s399 2026-04-27T05:10:12.625935+00:00 Insights on SARS-CoV-2: Emerging Outbreaks of Viral Infections and the Need for Heightening the Antiviral Research 2020-10-18 10.5530/ijper.54.3s.137 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-390.pdf Background: Today, about 47 life threatening viruses have been notified for their outbreak potentials including SAR-CoV-2. The proximal origin of SARS-CoV-2 and its affinity to human ACE2 receptors ended in COVID-19 disease pandemic. The genome of SARS-CoV-2 is quite complex and unclear, thus the progress on new antiviral drugs and vaccine discovery is hampered. Worldwide, Indian horizon has emerged as potential source for supply of drugs like hydroxychloroquine, remdesvir, ritonavir lopinavir, Emerging viruses, Antiviral, COVID-19, Pharma industries, Indian Horizon, SARS-CoV-2 genome https://www.ijper.org/article/54/3s/s586-s592 2026-04-27T06:27:27.63+00:00 HPTLC Densitometric Quantification of Kaempferol from Leaves of Euphorbia neriifolia 2020-10-18 10.5530/ijper.54.3s.158 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-586.pdf Objectives: To study HPTLC densitometric quantification of kaempferol in aqueous extract fraction (EN6) of leaves of Euphorbia neriifolia Linn. Methods: Chromatographic method was employed on pre-washed and pre-activated 10.0 x 10.0 cm aluminum Lichrosphere HPTLC plates pre-coated by silica gel 60 F254 of 0.2 mm thickness layer as a stationary phase. Solvent system toluene: ethyl acetate: formic acid (6:4:1 v/v/v) was used. Densitometric analysis of kaempferol was carried out at 254 nm in absorp Euphorbia neriifolia Linn, Aqueous extract fraction, Leaves, HPTLC, Kaempferol, Identification, Quantification, Validation https://www.ijper.org/article/54/3s/s552-s561 2026-04-27T06:24:41.065164+00:00 In-silico Strategies of Some Selected Phytoconstituents from Zingiber officinale as SARS CoV-2 Main Protease (COVID-19) Inhibitors 2020-10-18 10.5530/ijper.54.3s.154 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-552.pdf Background: Zingiber officinale (Zingiberaceae) has been utilized to remedy many afflictions of humans. Literary works illustrate that it possesses numerous biological activities. Methods: Today, research study intended to recognize the Phyto-derived antiviral substances from Zingiber officinale against COVID-19 main protease enzyme and to understand the molecular basis of its activity. Methods: In the present study, 42 molecules obtained from Z. officinale, which are retrieved from the Pubmed d Zingiber officinale, ADMET, PyRx, Physico-chemical, PASS analysis https://www.ijper.org/article/54/3s/s633-s643 2026-04-27T06:30:14.196419+00:00 Synthesis and Characterization of Some Novel N-Phenylpyrazole Analogues for the Evaluation of their Potentials as Anticancer, Antimicrobial and Antioxidant Agents 2020-10-18 10.5530/ijper.54.3s.163 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-633.pdf Objectives: With a view to invent new anticancer agents, the authors proposed to prepare a series of N-phenylpyrazole derivatives by introducing biologically active pharmacophores viz., Fluoro/Fluoromehtyl benzamide and 2, 3-dihydrobenzo[b][1,4] dioxin at 3-, 5- positions of N-phenyl pyrazole motif respectively. Methods: The newly formed products are characterized by 1H NMR, 13C NMR, Mass and FTIR spectroscopic techniques and are subjected to screened for anticancer activity against human liver Anticancer, BCL2, Chalcone, Hep G2, Molecular docking, Pyrazole https://www.ijper.org/article/54/3s/s671-s676 2026-04-27T06:32:06.740112+00:00 Method Development and Validation of Ephedrine and Pseudoephedrine in Horse Urine by Liquid Chromatography-Tandem Mass Spectrometry 2020-10-18 10.5530/ijper.54.3s.167 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-671.pdf Background: A comprehensive, fast and precise method for the quantification of ephedrine and pseudoephedrine in horse urine was established and validated utilizing Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) followed by the necessities of Association of Official Racing Chemists (AORC), Federation of Equine International (FEI) and International Council for Harmonization (ICH) guidelines. Methodology: The processing of samples was performed by de conjugation accompanied by enzymatic Ephedrine, Pseudoephedrine, ICH Guidelines, Doping control, Mass, spectrometry, AORC, Validation https://www.ijper.org/article/54/3s/s687-s694 2026-04-27T06:33:11.882204+00:00 Simultaneous Quantification of Quercetin and Syringic Acid in Methanolic Extract of Leucas lavandulifolia by using Validated HPTLCDensitometric Method 2020-10-18 10.5530/ijper.54.3s.169 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-687.pdf A simple, sensitive and reliable High Performance Thin Layer Chromatography (HPTLC) method was developed for the simultaneous quantification of bioactive compounds i.e quercetin and syringic acid in Leucas lavandulifolia. Methanolic extract used on HPTLC silica gel 60 F254, 10×10 (Mark) plate for the separation and quantification of bioactive compounds by using toluene: ethyl acetate: formic acid (7: 2.5: 0.5 v/v) as mobile phase. The used mobile system gives well-resolved bands of quercetin (Rf HPTLC, Leucas lavandulifolia, Quercetin, Syringic acid, DPPH, Hydroxyl, Radical-Scavenging https://www.ijper.org/article/54/3s/s537-s551 2026-04-27T06:23:39.009115+00:00 Arecoline, Hesperidin and Trifluoperazine-mediated Cytotoxicity and Cell Death Potential in NIH/3T3 Fibroblasts Cells –Toxicity/Safety Assessment in a NIH/3T3 Model Fibroblast Cell Line 2020-10-18 10.5530/ijper.54.3s.153 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-537.pdf Aim/Background: Arecoline is considered to be the principal etiologic agent for Oral Sub mucous Fibrosis (OSF) with the buccal fibroblasts being the major target. Hence, this model alkaloid has been used to evaluate toxicity and cell death potential in NIH/3T3 cells and compared with that of Hesperidin. Materials and Methods: Toxicity and cell death, for the two molecules, was tested using a battery of assays (MTT assay based cytotoxicity assessment; AO/EtBr assay-based determination of the perc Arecoline, Hesperidin, Trifluoperazine, S100A4, Cell Death, Protection-, Challenge, Challenge-Protection https://www.ijper.org/article/54/3s/s695-s704 2026-04-27T06:34:32.085191+00:00 Impact of Verbal and Web-based Patient Education Programs Driven by Clinical Pharmacist on the Adherence and Illness Perception of Hypertensive Patients 2020-10-18 10.5530/ijper.54.3s.170 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-695.pdf Background: Patient education is a substantial factor for the management of inveterate diseases. The aim of this study is to assess the impact of patient education given by clinical pharmacist using different (verbal and web-based) education techniques on the adherence and illness perception of hypertensive patients. Methods: It is a prospective observational study. Patients selected were randomly assigned to 2 groups: Verbal Based Education Group (VBEG) and Web Based Education Group (WBEG). Pat Patient education, Hypertension, Adherence, Knowledge, Web-based, Education, Illness perception https://www.ijper.org/article/54/3s/s521-s528 2026-04-27T05:27:07.703258+00:00 Effect of Atorvastatin on 7,12-Dimethylbenz (α) Anthracene and Testosterone-induced Prostatic Intraepithelial Neoplasia in the Prostate of Wistar Rats: Role of TRPM7 2020-10-18 10.5530/ijper.54.3s.151 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-521.pdf Aim/Background: The current study was conducted to examine the influence of atorvastatin in experimentally induced prostatic intraepithelial neoplasia in rats. TRPM7 is a potential therapeutic target for treatment of prostate cancer. Materials and Methods: In this study, we investigated the effects of atorvastatin (25 and 50 mg/kg/BW p.o.) on cell proliferation of prostate induced by a sequential regimen of testosterone plus single administration of 7,12-Dimethylbenz(a) anthracene. Results: Resu Atorvastatin, Testosterone, PIN, Ca2+/Mg2+ ratio, TRPM7 https://www.ijper.org/article/54/3s/s705-s715 2026-04-13T05:54:54.870346+00:00 Machine Learning-Based Decision Support System for Early Detection of Breast Cancer 2020-10-18 10.5530/ijper.54.3s.171 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-705.pdf Background: Breast cancer is one of the leading causes of death of women in the United States and also one of the most malignant cancer among women worldwide. Early, more accurate detection of breast cancer enables extended longevity at a reduced cost. Towards this, analyzing the available big data using tools, such as Machine learning-based decision support systems can improve the speed and accuracy of early detection of breast cancer. In this paper, we examined the prediction performance of va Breast cancer, Data analysis, Machine learning, Feature selection, Decision, support system https://www.ijper.org/article/54/3s/s601-s609 2026-04-13T05:54:54.870346+00:00 Anti-diarrheal Activity of Caffeine: A Modulatory Effect with Loperamide and through 6FH5 (PIK3CG) Protein Interaction Pathway 2020-10-18 10.5530/ijper.54.3s.160 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-601.pdf Background: Caffeine (CAF) is known for its central nervous system stimulatory effect. Although, CAF use in diarrhea, especially in Runner's diarrhea is still controversial, but it has been reported that dark tea containing CAF has anti-diarrheal effect on Sennaemediated diarrhea in mice. Aim: To evaluate the anti-diarrheal effect of CAF and its modulatory effects on the standard anti-diarrheal drug loperamide (LOP), an opioid receptor agonist. Materials and Methods: CAF (15 mg/kg, i.p.) with or Mus musculus, Caffeine, Castor oil, Diarrhea, Adenosine receptor https://www.ijper.org/article/54/3s/s423-s432 2026-04-13T05:54:54.870346+00:00 Columns in Pharmaceuticals: For Primers 2020-10-18 10.5530/ijper.54.3s.140 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-423.pdf Chromatographic processes have a crucial role in the manufacturing of pharmaceuticals, bio-pharmaceuticals, polypeptides, proteins, enzymes and antibodies. They are apprehended, purged and elegant by size exclusion, ion exchange, reverse phase, hydrophobic interaction or the affinity chromatographic processes. The key to the proper selection of column is the knowledge of the principles of the chromatographic process (HPLC, Ion exchange, size exclusion, gas chromatography, UPLC). A Chromatographi Column, Specifications, HPLC, Size exclusion, Gas chromatographic, UPLC, Bonded Phase https://www.ijper.org/article/54/3s/s620-s632 2026-04-13T05:54:54.870346+00:00 In silico Docking and 3D-QSAR Studies of Novel N’-substituted-(pyrrolyl-phenoxy) Acetohydrazides as Enoyl-ACP Reductase Antagonists 2020-10-18 10.5530/ijper.54.3s.162 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-620.pdf In search of potent anti-mycobacterial agents, enoyl-ACP reductase enzyme found to be most probable due to its imperative role in type II fatty acid synthesis (FAS), while mycolic acid production in Mycobacterium tuberculosis (M. tuberculosis), which is the appropriate entity for the discovery of antimycobacterial agents due to its primary role in the metabolism. Hence, blocking of enoyl ACP reductase would be important to develop novel antitubercular drugs development. Pyrrole, which is one of Pyrrol-(1H-yl-phenoxy)acetohydrazides, Enoyl ACP reductase (InhA), Molecular Docking, 3D-QSAR, CoMFA, CoMSIA https://www.ijper.org/article/54/3s/s433-s437 2026-04-13T05:54:54.870346+00:00 A Review on Virtual Classroom 2020-10-18 10.5530/ijper.54.3s.141 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-433.pdf A virtual classroom is an online learning method that is carried out via internet that provides communication for distance learner just like face-to-face classroom. This field of education is going to be in high trend in the upcoming days and soon will be replacing the traditional mode of education as internet dependent learning is growing rapidly in almost every schools and colleges. Two major forms of virtual classroom are synchronous and asynchronous. In virtual classroom it’s the choice of s Virtual classroom, Synchronous, Asynchronous, Education, Challenges https://www.ijper.org/article/54/3s/s381-s389 2026-04-13T05:54:54.870346+00:00 SARS-CoV-2: The Prominent Role of Non-structural Proteins (NSPS) in COVID-19 2020-10-18 10.5530/ijper.54.3s.136 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-381.pdf COVID-19, an infectious contagious viral (SARS-CoV-2) disease, associated with morbidity and mortality from respiratory pandemic worldwide. Currently, COVID-19 has no targeted treatment strategies and has been declared by WHO as a global health emergency. SARS-CoV-2, an enveloped, positive-sense, betacoronavirus (βCoV) spreading rapidly due to its potential pre- and asymptomatic transmission (silent transmission). The viral replicase single-stranded genome encodes for two open reading frame gene COVID-19, SARS-CoV-2, Non-structural proteins, Open reading frames, Polyproteins, Phylogenetic analysis https://www.ijper.org/article/54/3s/s492-s504 2026-04-13T05:54:54.870346+00:00 Effective Single Drug Treatment of Lymphatic Filariasis through Enhanced Transdermal Delivery of Ivermectin Liposomes using Solid and Dissolving Microneedles 2020-10-18 10.5530/ijper.54.3s.148 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-492.pdf Objectives: The present investigation was to study the combination of liposomes (LP) and microneedles (MNs) as a single drug treatment approach for the delivery of an antifilarial drug, ivermectin (IVM) in which the role of MN arrays (commercial solid MNs of different lengths and laboratory fabricated polymeric dissolving MNs of length 0.6mm) in increasing the in vitro permeation of IVM-LP across pig ear skin was studied. Experimental: IVMLP was formulated and optimized using solvent injection m Lymphatic filariasis, Ivermectin, Liposomes, Microneedles, Transdermal, drug delivery systems, Bioavailability https://www.ijper.org/article/54/3s/s562-s569 2026-04-13T05:54:54.870346+00:00 Protective Effect of Rhizophora mucronata Leaves on Hepatic Oxidative Stress, Serum Cytokines and Insulin Resistance in Type 2 Diabetic Rats 2020-10-18 10.5530/ijper.54.3s.155 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-562.pdf Aim: Glucose homeostasis is mainly controlled by liver, which is altered in diabetes. Metabolic alteration and insulin resistance develop due to oxidative stress and inflammation. Plant secondary metabolites have therapeutic relevance in diabetes and associated complications. Present study evaluated the effect of hydro-alcoholic extract of Rhizophora mucronata leaves (RME) in diabetes induced hepatic oxidative stress, serum cytokines and insulin resistance in Streptozotocin-Nicotinamide induced Antioxidant, Cytokines, Hepatoprotective, Insulin resistance, Rhizophora, mucronata https://www.ijper.org/article/54/3s/s473-s484 2026-04-13T05:54:54.870346+00:00 Solid Dosage Forms: A Detailed Research on Non-conforming Product Quality 2020-10-18 10.5530/ijper.54.3s.146 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-473.pdf Introduction: Any defects in pharmaceutical products lead to minor, major, or critical deviation and if such a product is released, it also leads to product recalls and legal actions. In such cases, the concern is about patient’s safety rather than the company’s economy and fame. This study aimed to investigate the various quality defects which have occurred in marketed tablets. Materials and Methods: The investigation was carried out which involved identification of defects, categorizing the ty Tablets, Solid dosage forms, Tablet defects, Patient perception, Investigation, Quality Assurance https://www.ijper.org/article/54/3s/s677-s686 2026-04-27T06:32:42.958861+00:00 A Validated Stability-indicating RP-HPLC Method for Piperine Estimation in Black Pepper, Marketed Formulation and Nanoparticles 2020-10-18 10.5530/ijper.54.3s.168 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-677.pdf Aim: The aim of the study was to develop and validate a simple stability indicating reversephase High Performance Liquid Chromatography (RP-HPLC) method for quantitative analysis of piperine in Ayurvedic marketed formulation, black pepper and cubosome nanoformulation. Methods: The method was established by using Luna C18 HPLC column using a mobile phase consisting of acetonitrile: 0.01% ortho phosphoric acid (60:40, v/v; pH 3), delivered isocratically with flow rate of 1 mL/min and detected at 3 RP-HPLC, Piperine, Cubosome, Stress degradation, Ayurvedic marketed, formulations https://www.ijper.org/article/54/3s/s716-s721 2026-04-13T05:54:54.870346+00:00 Assessment of Knowledge of Diabetic Patients about Glycemic Abnormalities and Medicine Storage in Makkah during Hajj Pilgrimage 2020-10-18 10.5530/ijper.54.3s.172 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-716.pdf Objectives: The main objective of this research was to evaluate the awareness about symptoms of diabetes and dealing with those symptoms, management and storage of drug especially for the heat sensitive hormone (insulin) by diabetic patients participating in Hajj and the residents of Makkah. Methods: This cross-sectional study was conducted for diabetic patients participating in Hajj and the residents of Makkah. The sample was composed of 459 diabetic patients, typed questionnaires were administ Hajj, Diabetics, Storage, Insulin, Awareness https://www.ijper.org/article/54/3s/s411-s422 2026-04-13T05:54:54.870346+00:00 3D-printed Drugs: A Fabrication of Pharmaceuticals towards Personalized Medicine 2020-10-18 10.5530/ijper.54.3s.139 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-411.pdf Background: Three-dimensional (3D) printing fabricates a structure by depositing materials layer-by-layer to form an object. Drug personalization receives attention due to problems arising from drug treatments such as undesirable side effects and ineffective drug therapy among pediatric and geriatric patients. Hypothesis: Conventional dosage form faces issues such as non-adherence to medication, ineffective treatment due to non-preferable dosage form and non-optimized drug release. Personalized 3D-printed drugs, Personalized dosing, 3D printer, Polypills, Patient, compliance, Drug release profile https://www.ijper.org/article/54/3s/s512-s520 2026-04-13T05:54:54.870346+00:00 Fabrication of Triprolidine∙HCl Transdermal Drug Delivery System and Pharmacokinetic Studies 2020-10-18 10.5530/ijper.54.3s.150 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-512.pdf The purpose was to examine and analyze the matrix system of Triprolidine∙HCl wth the selected polymer ethyl cellulose. We achieved in vitro permeation studies using Keshary Chien diffusion cells across guinea pig skin. Considering the success of permeation enhancers with differing concentrations to enhance the permeation rate. The performed the in vitro dissolution of the developed transdermal patches. The in vivo analysis was carried out on male albino rabbits the drug release was determined by Matrix TDDS, Triprolidine∙HCl, Ethyl cellulose, Pharmacokinetics https://www.ijper.org/article/54/3s/s442-s456 2026-04-13T05:54:54.870346+00:00 Novel SARS-CoV-2 and COVID-2019 Outbreak: Current Perspectives on Plant-Based Antiviral Agents and Complementary Therapy 2020-10-18 10.5530/ijper.54.3s.143 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-442.pdf The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) caused the novel Corona Virus Disease 2019 (COVID-19), which has been defined as a pandemic by the World Health Organization (WHO) in 2020. The rapid global spread of SARS-CoV-2 virus as a global health emergency has emphasized to findeffective treatment strategies in clinical trials. The several drug trials including Lopinavir (LPV) and Ritonavir, Chloroquine (CLQ), Hydroxychloroquine, Favipiravir (FPV), Remdevisir (RDV), Nitazoxa SARS-CoV-2, COVID-19, Outbreak, Medicinal plants, Antiviral https://www.ijper.org/article/54/3s/s457-s463 2026-04-13T05:54:54.870346+00:00 COVID-19 Vaccine Development, Trials and Tribulations 2020-10-18 10.5530/ijper.54.3s.144 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-457.pdf The coronavirus disease 19 (COVID-19) is a pandemic viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, COVID-19 has affected 210 countries and territories around the world. But there is no clinically approved antiviral drug or vaccine against COVID-19. Governments, private manufactures, academic institutions and non-profit organizations are working hard at a breakneck pace to develop a vaccine for COVID-19. However, vaccine development is very leng Candidate Vaccine, Corona Virus, COVID-19 Vaccine, SARS-CoV-2, Vaccine Clinical Trial, Vaccine Development https://www.ijper.org/article/54/3s/s644-s656 2026-04-13T05:54:54.870346+00:00 A Novel Validated Stability Indicating Analytical Method for Simultaneous Quantification of Metformin Hydrochloride and Empagliflozin in Bulk and Marketed Formulation by HPTLC using Box-Wilson Experimental Design Approach 2020-10-18 10.5530/ijper.54.3s.164 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-644.pdf Background: A novel stability indicating analytical method was developed and validated by High Performance Thin Layer Chromatography (HPTLC) using Design of experiment approach. The proposed method is useful for quantification of Metformin hydrochloride and Empagliflozin in bulk and its dosage forms simultaneously. Design of experiment approach was applied for optimization of chromatographic conditions. Materials and Methods: For optimization process independent variables were used as Isopropyl Method development, Validation, HPTLC, Stability studies, DoE https://www.ijper.org/article/54/3s/s438-s441 2026-04-13T05:54:54.870346+00:00 Using Link and Major System of Memory to Memorise, Remember and Recall Pharmaceutical Sciences Better 2020-10-18 10.5530/ijper.54.3s.142 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-438.pdf Traditional memory techniques like mnemonics, flashcards and outline have been used to memorise and recall information as rote learning is not something that can be completely avoided in education. Recently, two memory techniques that are considered superior to traditional memory techniques-link and major system of memory are being widely used to memorise a large amount of data in a very short time. The link and major system of memory are based on three basic principles: Observation, association Link method of memory, Major system of memory, Rote learning, Observation, association, Pharmaceutical sciences https://www.ijper.org/article/54/3s/s400-s410 2026-04-13T05:54:54.870346+00:00 Attitude, Anxiety, Psychological Effects and Prevention during COVID-19 in India 2020-10-18 10.5530/ijper.54.3s.138 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-400.pdf With previous health warnings, personal anxieties could feed behavioral changes with many people of India considering notable changes in their transportation use and anticipating in preparation the purchase of goods, particularly masks. Asian respondents were especially likely to have talked about the pandemic with friends, whereas onefourth of respondents globally had talked about the pandemic with their family. Our data on the correlation indicates that these conversations may increase existin COVID-19, Psychology, Attitude, Lockdown, Anxiety, Quarantine https://www.ijper.org/article/54/3s/s610-s619 2026-04-13T05:54:54.870346+00:00 Synthesis and QSAR Studies of Novel Pyrazoline Derivatives as Antiproliferative Agent 2020-10-18 10.5530/ijper.54.3s.161 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-610.pdf Background: Regardless of recent advances in the biological processes leading to the development of cancer, there is still a need for new and effective agents to help bring this disease under control. The revelation of the anticancer properties of pyrazoline makes this scaffold remarkable for research and development as an anticancer. Methods: A series of synthetic chalcones and pyrazoline derivatives were synthesized, characterized IR, 1H NMR and mass spectral analysis and evaluated for their A Pyrazoline, QSAR, SRB assay, MCF-7, Antiproliferative activity https://www.ijper.org/article/54/3s/s593-s600 2026-04-13T05:54:54.870346+00:00 Phytoformulation of Tagetes patula for Improving Permeability and Prevention of Hyperlipidaemia 2020-10-18 10.5530/ijper.54.3s.159 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-593.pdf The present study was aimed to formulate phytoformulation of Tagetes patula (MSTP) and its evaluation for antihyperlipidemic activity with triton X-100 and propyl thiouracil induced hyperlipidaemia models. Microsuspension of T. patula extract (50 and 100 mg; MSTP) was developed by precipitation technique. MSTP was assessed for its particle size, pH and drug entrapment efficacy. The results confirmed that microsuspension prepared with Tagetes patula extract (MSPT) showed average particle size 5.9 Tagetes patula, Micro suspension, Triton X-100, PTU, GC-MS https://www.ijper.org/article/54/3s/s570-s579 2026-04-13T05:54:54.870346+00:00 In vitro Antioxidant Potential and Cytotoxicity Study of Asparagus aethiopicus L. Extracts on HT-29 Human Colon Cancer Cell Line 2020-10-18 10.5530/ijper.54.3s.156 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-570.pdf Objectives: To decide the phytochemical constituents, antioxidant and anticancer potential of Asparagus aethiopicus L. extracts on HT-29 human colon malignant growth cell line. Methods: The roots of plant were exposed to Hot Soxhlet continuous extraction with expanding polarity of solvents viz., pet ether, chloroform, ethanol and aqueous maceration. Qualitative phytochemical screening was completed by utilizing distinctive phytochemical tests. The antioxidant potential was tried utilizing 2, 2-d Phytochemical, Antioxidant, Anticancer, Colon cancer, Asparagus, aethiopicus https://www.ijper.org/article/54/3s/s505-s511 2026-04-13T05:54:54.870346+00:00 Development and Characterization of Mucoadhesive Buccal Gel Containing Lipid Nanoparticles of Triamcinolone Acetonide 2020-10-18 10.5530/ijper.54.3s.149 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-505.pdf Background: Triamcinolone Acetonide is a synthetic glucocorticosteroid which has been used for its immunosuppressive and anti-inflammatory activity belonging to BCS class IV, yet it is not recommended to be used at higher doses due to its possible adverse effects. Lipid nanoparticle systems are good carriers for poor water soluble drugs, improve permeability and show sustained drug release. Materials and Methods: Triamcinolone Actinide was formulated as Nanostructured Lipid Carriers. High shear Triamcinolone Acetonide, Nanostructured lipid carriers, Mucoadhesive buccal, gel, Factorial Design, Response Surface plot https://www.ijper.org/article/54/3s/s580-s585 2026-04-13T05:54:54.870346+00:00 Clot Lysis Capacity of Andrographis paniculata and its Pure Compound Andrographolide 2020-10-18 10.5530/ijper.54.3s.157 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-580.pdf Background: Andrographis paniculata and its main components andrographolide (AGL) have been reported for their promising cardio-protective effects in experimental animals. Aim: To investigate clot lysis activity of A. paniculata and AGL. Materials and Methods: The clot lysis activity of the aqueous A. paniculata stem extract (AAP) and AGL was investigated on clotted human blood by using streptokinase (SKE) as a standard drug. Results: Both AAP and AGL showed a concentration-dependent clot lysis Andrographis paniculata, Aqueous extract, Andrographolide, Atherothrombosis, Human blood https://www.ijper.org/article/54/3s/s464-s472 2026-04-13T05:54:54.870346+00:00 Rational Design and Characterization of Transdermal Patch of Irbesartan for Hypertension 2020-10-18 10.5530/ijper.54.3s.145 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-464.pdf Background: Irbesartan is hypertensive drugs approved for high blood pressure and protect the kidneys damage due to diabetes. It is an angiotensin receptor blockers, belongs to BCS class II, exhibit low and variable oral bioavailability due to its poor aqueous solubility. Therefore, it is need to enhancement of dissolution rate and bioavailability. The objective of this study was to develop a transdermal patches system of Irbesartan to reduce the above drawback. Methods: Various batch of Irbesar Irbesartan, Transdermal patch, Polymer, Formulation, Hypertension, Therapeutic https://www.ijper.org/article/54/3s/s657-s666 2026-04-13T05:54:54.870346+00:00 Application of Design of Experiment Based Innovative Approach in Method Development and Validation of RP-HPLC for Estimation of Azilsartan in Bulk and Pharmaceutical Tablet Dosage Form 2020-10-18 10.5530/ijper.54.3s.165 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-657.pdf Aim: Azilsartan is an angiotensin II receptor blocker used in the treatment of hypertension. Using the DoE based approach in reversed-phase high-performance chromatography method was developed and validated as per ICH guidelines. Materials and Methods: The separation of Azilsartan using the Qualisil 5 BDS C18 column (250 x 4.6mm, particle size 5μ) in low-pressure gradient mode with photodiode array detector at 249nm. For optimization of chromatographic conditions for Azilsartan from its formulat Azilsartan, ANOVA, Box-Behnken design, DoE approach, Robustness, Validation https://www.ijper.org/article/54/3s/s667-s670 2026-04-13T05:54:54.870346+00:00 Novel Validated UV Spectroscopic Method for Routine Analysis of Decitabine Drug Substance 2020-10-18 10.5530/ijper.54.3s.166 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3s-667.pdf Objectives: In the proposed study, a basic, novel, protected economic, delicate and cost-effective UV-Spectrophotometric technique for the analysis of Decitabine which is antineoplastic drug. Methods: The created method was approved according to ICH rules. The decitabine indicated maximum absorption at 221 nm. This strategy can successfully apply for estimation of Decitabine in active pharmaceutical ingredient (API) form for routine examination with UV identification at 221 nm. A Shimadzu UV-Vis Decitabine, UV-spectroscopy, Validated method, ICH guidelines, Beer’s, Lambert’s law, Analysis https://www.ijper.org/article/54/3/541-549 2026-04-13T05:54:56.122416+00:00 Novel Oral Drug Delivery Systems for Steroids: Overview and Recent Updates 2020-08-22 10.5530/ijper.54.3.102 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-541.pdf This review summarises the oral route of drug delivery of steroids. Oral drug delivery is widespread owing to its non-invasive nature which complements high patient compliance. This article summarises the problems associated with oral delivery of steroids including bioavailability. In this review, a brief description of the novel types of drug delivery systems of steroids such as microspheres, nanoparticles, solid lipid nanoparticles, multimatrix tablets, pellet technology, liposomes are present Steroids, Oral delivery, Novel drug delivery, Drug carriers, Controlled release, Patient compliance, Steroids, Oral delivery, Novel drug delivery, Drug carriers, Controlled release, Patient compliance https://www.ijper.org/article/54/3/610-617 2026-04-13T05:54:56.122416+00:00 Fabrication and Characterization of Chitin Hydrogel Nano Silver Fused Scaffold for Wound Dressing Applications 2020-08-22 10.5530/ijper.54.3.110 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-610.pdf Aim/Background: A scaffold is a wound dressing material which can be fabricated in the shape of the tissue that we want to restore in our body depending upon their structural and functional requirements. Chitin is the carbon-based resource having boundless activity as a wound healing accelerator. By the addition of silver nanoparticles, the wound remedial ability and antiseptic activity of chitin can be boosted. Materials and Methods: Chitin was obtained from the crab shell by demineralization, Chitin, Scaffold, Nanosilver, Hydrogel, Wound dressing https://www.ijper.org/article/54/3/705-713 2026-04-13T05:54:56.122416+00:00 Bioactivity Guided Antidiabetic Formulation Development of Tridax procumbens Linn Leaves 2020-08-22 10.5530/ijper.54.3.121 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-705.pdf Purpose: Diabetes mellitus is a global health problem as it is one of the complex disease and main causes of premature illness and death. The present study was focused to scientifically overcome bioavailability drawbacks of Tridax procumbens Linn. and improve its medicinal use of for the treatment diabetes by formulating it into microemulsion from. In this study oil in water microemulsion of Tridax procumbens Linn leaves extract was prepared using olive oil, Tween 80 and propylene glycol for ora Tridax procumbens, Microemulsion, Alloxan-induced diabetes, Hypoglycemic, activity, Bioavailability https://www.ijper.org/article/54/3/668-673 2026-04-13T05:54:56.122416+00:00 Apigetrin Inhibits Thyroid Cancer Cell Growth and Proliferation through Down-Regualtion of HIF1α and VEGF Expression 2020-08-22 10.5530/ijper.54.3.116 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-668.pdf Aim: Thyroid cancer is a commonly detected endocrine malignant tumour which accounts for 1% of the total human cancers. The present study was aimed to investigate the effect of apigetrin on anaplastic thyroid cancer cell viability and understand the mechanism involved. Materials and Methods: Fluorescent microscopy using diamidino-2- phenylindole (DAPI)staining was used to examine the nuclear fragmentation. Changes in protein expression were analysed by Western blot analysis and migration potenti Scutellaria, Papillary, Follicular, Terpenoid, Pharmacophore https://www.ijper.org/article/54/3/732-739 2026-04-13T05:54:56.122416+00:00 Mimosa pudica Modulates Neuroactive Ligand- Receptor Interaction in Parkinson’s Disease 2020-08-22 10.5530/ijper.54.3.124 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-732.pdf Introduction: Mimosa pudica is scientifically reported for the enhancement of memory in multiple animal models including Parkinson’s disease (PD); however, the probable molecular mechanism for this effect has not been explained yet. The present study demonstrates the probable molecular mechanism to improve memory via in silico techniques. Materials and Methods: Phytoconstituents present in M. pudica and their targets involved in Parkinson’s disease were identified using open-source databases and Luteolin, Mimosa pudica, Network pharmacology, Parkinson’s disease, Quercetin https://www.ijper.org/article/54/3/771-780 2026-04-13T05:54:56.122416+00:00 Novel Quinolone Substituted Imidazol-5(4H)-ones as Anti-inflammatory, Anticancer Agents: Synthesis, Biological Screening and Molecular Docking Studies 2020-08-22 10.5530/ijper.54.3.129 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-771.pdf Background: Quinolones and imidazolones are important heterocyclic moieties which have been reported to possess potent anti-inflammatory and anticancer properties. The activity of these compounds were related to inhibition of nuclear factor-kappaB (NF- κB) which is one of the important targets studied for designing of anti-inflammatory and antitumor drugs. Further, hybrid pharmacophore approach is used in the present study for designing potent molecules. Objectives: Aim of the study is to synthe Anti-inflammatory, Anticancer, Docking, Quinolone, Imidazolone, NF-κB https://www.ijper.org/article/54/3/698-704 2026-04-25T10:09:42.265557+00:00 Nostocine A Derivatives as Human DNA Topoisomerase II-alpha Inhibitor 2020-08-22 10.5530/ijper.54.3.120 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-698.pdf Introduction: Due to heavy morbidity and mortality from cancer, the designing of newer drugable molecules against breast cancer is the call of day. As, Schiff-base sulfonamides have been widely used in tumor treatments. Methods: Nostocine-sulfonamide (NS) Schiff-base molecules were designed with tools of bioinformatics against the target enzyme, human topoisomerase II-alpha (topo IIa) against breast cancer. The designed NS conjugates were assessed by RO5, ADMET and molecular docking. Results: He Pyrazolotriazine, Nostocine A, Cyanobacterium, Nostoc spongiforium, Breast, cancer, Docking https://www.ijper.org/article/54/3/602-609 2026-04-13T05:54:56.122416+00:00 Solvent Drop Grinding Approach Assisted Development of Glimepiride Co-crystals: Solubility Enhancement Journey of BCS Class-II Product 2020-08-22 10.5530/ijper.54.3.109 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-602.pdf Background: Glimepiride has limited aqueous solubility and majorly suffers from bioavailability issues that eventually reduce the pharmacotherapeutic potentials of the moiety. Materials and Methods: For the possible augmentation of all the crucial factors, co-crystals were developed using a Generally Recognized As Safe (GRAS) co-former (caffeine) in the presence of few drops of solvent (acetone) by employing a very simple green approach (solvent drop grinding method). The pharmacokinetic study o Glimepiride, Caffeine, Co-crystal, Bioavailability, Solubility, Green technique https://www.ijper.org/article/54/3/491-495 2026-04-13T05:54:56.122416+00:00 Is Covid-19 Sibling of SARS and MERS? A Review on: Novel Covid-19 2020-08-22 10.5530/ijper.54.3.97 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-491.pdf Pandemic times: Contemporary public health catastrophe terrifying the world over with the rapidly spreading of 2019-nCoV or SARS-CoV-2. Coronaviruses have pass over the species barriers to cause fatal disease in human since the 2002 and 2012; Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome respectively. It was suggested that SARS-CoV and SARS-CoV-2 are firmly related to each and hypothesized it originated in animal (bats) and was transmitted to humans. Though Novel Covid-1 SARS-CoV-2, Corona virus, Epidemic, Pandemic, PCR https://www.ijper.org/article/54/3/690-697 2026-04-13T05:54:56.122416+00:00 Role of Heme Oxygenase- 1(HO-1) and Endothelin-1 (ET-1) in Modulation of Cardioprotective Effect of Ischemic Postconditioning in Diabetic Rat Heart 2020-08-22 10.5530/ijper.54.3.119 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-690.pdf Background: We have recently reported that heme oxygenase-1 (HO-1) is involved in ischemic preconditioning-mediated cardioprotection by promoting nitric oxide (NO) release into diabetic rat heart (DRH). The upregulation of HO-1 decreases the endothelin-1 (ET-1) production, which is a negative regulator of NO. In diabetes, the level of HO-1 is reduced while the level of ET-1 gets elevated. Thus, the present analysis was aimed to explore the concept of HO-1 and ET-1 in the abrogated cardioprotecti Heme oxygenase-1, endothelin-1, Ischemic postconditioning, Diabetic rat, heart, hemin, BQ-123 https://www.ijper.org/article/54/3/682-689 2026-04-25T10:08:37.977336+00:00 Exploring the Role and Mechanism of Imatinib in Chronic Unpredictable Mild Stress-induced Depression Model of Rats 2020-08-22 10.5530/ijper.54.3.118 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-682.pdf Aim: The study was planned to examine the potential effect of imatinib in chronic unpredictable mild stress (CUMS)-induced depression model of rats. Materials and Methods: Male rats were subjected to the 6-week CUMS with unpredictable stressors to induce depression and the imatinib was started from the 4th week (for 21 days during 6 weeks of the protocol). Results: CUMS significantly increased immobility time and decreased consumption of sucrose in the swimming and sucrose preference test respec CUMS, Depression, p-NF-kB, BDNF, Imatinib https://www.ijper.org/article/54/3/565-571 2026-04-13T05:54:56.122416+00:00 Correlation between Academic Evaluation Scores within the Undergraduate Medical Education: A Cross-sectional Study 2020-08-22 10.5530/ijper.54.3.105 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-565.pdf Introduction: There are several evaluations to assess the medical students finishing the courses. Examinations could be multiple-choice questions that tend to evaluate the memorization rather than analytical ability. Another is oral examination tests that evaluate the ability in analysing the specific cases. However, though the oral examination assesses by two examiners, still the subjectivity of the examiner cannot be ignored. This study aims to provide insight on the correlation between test s Education, Evaluation studies, Medical students, Undergraduates https://www.ijper.org/article/54/3/714-723 2026-04-13T05:54:56.122416+00:00 Neuroprotective Effects of Licorice Extracts in Tibial and Sural Transection Induced Neuropathic Pain in Rats 2020-08-22 10.5530/ijper.54.3.122 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-714.pdf Background: Neuropathic pain (NP) is the worst of tortures, a nerve wound may experience as a result of nerve damage or complication of diabetes/HIV /cancer. There are no defined guidelines for treatment. Available treatments have various side effects. Glycyrrhiza glabra (Licorice) has not been explored scientifically with respect to NP. Hence there is a dire need to develop treatment for NP which will be safe, effective and can be taken for prolonged time. The present study is to evaluate effec Glycyrizza glabra, Neuropathic pain, Tibial and Sural Transection, Antioxidant, Licorice root, Anti-inflammatory https://www.ijper.org/article/54/3/556-564 2026-04-13T05:54:56.122416+00:00 The Efficacy of PBL Model in Pathology and Pathophysiology Teaching in China: A Meta-analysis 2020-08-22 10.5530/ijper.54.3.104 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-556.pdf Purpose: To systematically evaluate the effect of PBL in Pathology and Pathophysiology teaching. Approach: CNKI, PubMed, WanFang Data, EMbase databases were electronically searched to collect randomized controlled trials (RCTs) of PBL model used in pathology and pathophysiology teaching in China from the database that has been constructed by September 20, 2019. Two researchers from the same research department independently screened and extracted literature materials for studying the evaluation PBL, LBL, Pathology, Pathophysiology, Meta-analysis https://www.ijper.org/article/54/3/550-555 2026-04-13T05:54:56.122416+00:00 Fast HPLC-DAD Method for Estimation of Catechin for Standardization of Extracts and Antiasthmatic Polyherbal Formulations Containing Albizia lebbeck 2020-08-22 10.5530/ijper.54.3.103 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-550.pdf Background: Many marketed polyherbal formulations containing Albizia lebbeck are available for treatment of allergic disorders such as asthma and bronchitis. But these formulations are not standardized in terms of markers. The present work discusses development and validation of a new, simple and rapid HPLC-DAD method for quantification of phytomarker- catechin in methanol extracts for standardization of extracts and polyherbal formulations containing Albizia lebbeck. Materials and Methods: HPLC Albizia lebbeck, Catechin, Fabaceae, HPLC, Shirish https://www.ijper.org/article/54/3/572-579 2026-04-13T05:54:56.122416+00:00 The First Objective Structured Practical Examination (OSPE) in Pharmacy Teaching in Poland: Designing, Implementing and Assessing the Results 2020-08-22 10.5530/ijper.54.3.106 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-572.pdf Background: Education of pharmacy students in preparation for their profession is still changing. It is therefore important to improve students’ skills necessary to provide pharmaceutical services according to the professional standards. One of the elements of the pharmacy curriculum is to teach and improve student’s practical and interpersonal skills e.g. solving drug problems. OSPE (Objective Structured Practical Examination) is one of a broad family of structured and objectified examinations Objective Structured Practical Examination, Pharmacy Students, Competence, Learning outcomes, Practical skills, Assessment, Pharmacy Education https://www.ijper.org/article/54/3/526-540 2026-04-13T05:54:56.122416+00:00 Biomaterials in 3D Printing: A Special Emphasis on Nanocellulose 2020-08-22 10.5530/ijper.54.3.101 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-526.pdf Aim and Background: The main objective of this review is to highlight nanocellulosic materials in 3D bioprinting. Three-dimensional (3D) bioprinting is on the verge of fabricating the artificial organ and living tissues. For the target construction the process of this 3D bioprinting involves layer-by-layer deposition of suitable biomaterials using predesigned data made by using Computer Aided Design (CAD) as an outline. However, only a handful of biomaterials are able to fulfil the considerable Cellulose, Bioprinting, Regenerative medicine, Biomaterials, Bioink https://www.ijper.org/article/54/3/654-667 2026-04-13T05:54:56.122416+00:00 Commiphora mukul and Quercetin Loaded Liposphere Gel: Potential Treatment for Psoriasis 2020-08-22 10.5530/ijper.54.3.115 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-654.pdf Background: Psoriasis is a chronic autoimmune skin disorder characterized by thick skin patches, which are typically red, scaly and itchy. Topical drug delivery is backbone in mild and moderate psoriasis as well as useful complementary therapy to systemic therapy in severe conditions. Aim: The attempt was made to formulate, optimized and evaluate novel liposhpere based drug delivery system containing anti-psoriatic herbal drug such as Commiphora mukul and Quercetin for treatment of psoriasis. Ma Commiphora mukul, Combination therapy, Imiquimod induced psoriasis, model, Lipospheres, Psoriasis, Quercetin https://www.ijper.org/article/54/3/761-770 2026-04-13T05:54:56.122416+00:00 In vivo Anti-diabetic and Anti-hyperlipidemic Activities of ethyl Acetate/Methanol Fractions of Feronia elephantum Fruit in type 2 Diabetic Rats: Via α-amylase and PPAR-γ by using in silico Approach 2020-08-22 10.5530/ijper.54.3.128 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-761.pdf Background: Obesity and overweight, together with physical inactivity, are projected to cause a huge proportion of the global diabetes burden. Natural products play a key role in the discovery of novel therapeutic agents. Aim: The present study aimed to elucidate in silico and in vivo anti-diabetic and anti-hyperlipidemic potential of Ethyl acetate (EFE) and ethyl acetate:methanol (EMFE) fractions of F. elephantum fruit in diabetic rats. Methods: Male Sprague-Dawley rats were induced type 2 diab Molecular Docking, Feronia elephantum, Anti-diabetic, Anti-hyperlipidemic, Streptozotocin, High Fat Diet https://www.ijper.org/article/54/3/798-808 2026-04-13T05:54:56.122416+00:00 The Significance of Quality Metrics in a Pharmaceutical Quality Management System – A Case Based Study 2020-08-22 10.5530/ijper.54.3.132 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-798.pdf Background: The pharmaceutical quality management system is a concept of management function that design and implement the “Quality policy”. The pharmaceutical manufacturing industries all over the world have just begun to apply the United States Food and Drug Administration (USFDA) guidelines in the 21st century. The study tries to identify the quality metrics based on Quality Indicators for a pharmaceutical industry and to investigate the utilization of quality KPIs. Methodology: The work expe Quality Metrics, CAPA, Key performance indicators, Deviation, Change, control https://www.ijper.org/article/54/3/740-749 2026-04-13T05:54:56.122416+00:00 Neuroprotective Effect of Vanda roxburghii Extract in Endothelin-1 (et-1) Induced Hippocampal Ischemic Damage and Ameliorate Cognitive Deficit 2020-08-22 10.5530/ijper.54.3.125 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-740.pdf Introduction: The concept of neuroprotection gaining considerable interest in search for novel therapy that has potential to preserve brain tissues and improve cognitive functions in ischemic brain damage. In the present study we evaluated the neuroprotective efficacy of hydro alcoholic extract of Vanda roxburghii in experimental models of ischemic hippocampal injury in rats. Materials and Methods: Ischemic hippocampal injury was induced by single intra-hippocampal injection of Endothelin-1 (80μ Stereotaxic, Hippocampus, Pyramidal cells, Morris water Maze, Lipid, peroxidation https://www.ijper.org/article/54/3/647-653 2026-04-13T05:54:56.122416+00:00 Application of Similarity Factor (f2) and Time Required to Drug Release (t%) Indicators for Dissolution Profiles Comparison of Paracetamol Tablets 2020-08-22 10.5530/ijper.54.3.114 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-647.pdf Introduction: The comparison of in vitro dissolution profiles is an integral step during the development of any generic product. However, using merely similarity factor (f2) as a dissolution parameter may not be adequate. Objectives: The present study was conducted to explore whether f2 alone suffices to adequately compare the dissolution profiles of tablets or both f2 and time required to percentage drug release (t%) generate closely similar results. Methods: The reference (R) and two generic p Similarity factor, Time to drug release, Dissolution profiles, Paracetamol, tablets, UV-Visible spectrophotometer, Statistical analysis https://www.ijper.org/article/54/3/580-588 2026-04-13T05:54:56.122416+00:00 A Learner Centered Approach of Teaching and Learning in Pharmacology: A Questionnaire Based Analysis of Student Cognizance and Experiences 2020-08-22 10.5530/ijper.54.3.107 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-580.pdf Background: Innovative and flexible educational methods like Problem Based Learning (PBL) and integrated teaching practices were integrated into the Pharmacology course in a manner that they complement the didactic lectures or, completely replace the lecture classes with the aim to optimize the educational atmosphere for a better learner experience. Aim: The present study is an attempt to gather feedback on newer teaching learning methods and audiovisual aids employed during the didactic lecture Teaching learning methods, PBL, Integrated teaching, Student perception, Audiovisual aids, Active learning https://www.ijper.org/article/54/3/517-525 2026-04-13T05:54:56.122416+00:00 Pharm D Program: Is it Necessary in BRICS? 2020-08-22 10.5530/ijper.54.3.100 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-517.pdf The various trajectories of the development of the Doctor of Pharmacy (Pharm D) programs in BRICS countries were reviewed individually, showing the progress of Pharm D programs in each context. Evidence from developed countries indicates that Pharm D programs have contributed towards the positive development of public health and a country’s local health requirements, with well-trained clinical pharmacists having a key role in the health and economic development of these emerging powers. The heal Pharm D, Pharmacy education, Clinical pharmacy, BRICS, Pharmacist https://www.ijper.org/article/54/3/819-825 2026-04-13T05:54:56.122416+00:00 Paediatric Focused Triggering Tool (PFTT) To Assess the Harm and its Utilization to Minimize the Levels of Harm among Children at a Tertiary Care Hospital 2020-08-22 10.5530/ijper.54.3.134 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-819.pdf Objectives: Very few paediatric trigger tools have been developed to assess harm in children. Hence, a Paediatric-focused trigger tool has been developed, assess its utility to measure the levels of harm, categorize and minimize them further. Methodology: The final 40 trigger tool developed by modifying IHI-GTT adult care, was prospectively tested for structural review of records (n=520) of paediatric population of a tertiary care hospital for incidence of adverse events (AE’s) with associated h Paediatric, Trigger tool, AEs, NCCMERP Index, Harm https://www.ijper.org/article/54/3/790-797 2026-04-13T05:54:56.122416+00:00 Development and Validation of Stability Indicating Method for Estimation of Buparvaquone by Forced Degradation Studies 2020-08-22 10.5530/ijper.54.3.131 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-790.pdf Aim: A lucid, rapid and precise stability-indicating method was developed by using HPLC for the estimation of Buparvaquone in bulk as well as pharmaceutical dosage form by forced degradation studies. Materials and Methods: Princeton C18 column (4.6 × 150 mm, 5μ) and mobile phase containing 1% glacial acetic acid and acetonitrile in the proportion of 5:95 v/v was used throughout the study. The flow rate was 0.9 ml/m and the detecting wavelength was kept as 251 nm using the PDA detector. Results: Buparvaquone, Forced degradation, Validation, RP-HPLC, Stability https://www.ijper.org/article/54/3/724-731 2026-04-13T05:54:56.122416+00:00 Extraction, Identification and Screening of Brassica oleracea var. italica Plenck (Broccoli) Floret to be an Alternative for Nanoparticle Formulations 2020-08-22 10.5530/ijper.54.3.123 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-724.pdf Background: Plant or plant extract act as a source of several abundant natural compounds such as flavonoids, phenolics, alkaloids, steroids, tannins, saponins and other nutritional compounds. The extract not only acts as reducing and stabilizing agents due to presences of various secondary metabolites for the bio reduction reaction but, also shows added pharmacological potential. Among others, a cruciferous vegetable like Broccoli is assumed to affect the growth of numerous forms of cancers sinc Broccoli, Extraction, Identification, Screening, Qualitative and Quantitative, Analysis https://www.ijper.org/article/54/3/826-834 2026-04-13T05:54:56.122416+00:00 Fabrication of Poly (Sebacic acid-co-ricinoleic-ester anhydride) with β-cyclodextrin-loaded Doxorubicin Implants and in vitro Characterization 2020-08-22 10.5530/ijper.54.3.135 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-826.pdf Background: Doxorubicin is an excellent molecule for the formation of biodegradable implants using the poly (sebacic acid-co-ricinoleic-ester anhydride) 70:30 w/w (poly[SARA] 70:30 w/w PSRA 7/3) polymer. Methods: The cylindrical implants were successfully produced by means of hot melt extrusion. We used differential scanning calorimetric (DSC) and X-ray diffraction (XRD) methods to identify the melting state and crystal type of blank and drug-loaded implants. A study was conducted on PSRA 7/3 w/ Poly(sebacic acid-co-ricinoleic-ester anhydride) 70:30 w/w, Doxorubicin, β-cyclodextrin, Cylinder, Biodegradable polymer, in vitro https://www.ijper.org/article/54/3/781-789 2026-04-13T05:54:56.122416+00:00 Synthesis, Characterization, Biological and Photoluminescence Study of Co(II) Complexes of Fused Heterocyclic Ring Systems 2020-08-22 10.5530/ijper.54.3.130 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-781.pdf Aim: To synthesize and characterize the transition metal complexes of fused heteroccylic ring systems. Background: Many of the fused ring heterocyclic compounds were found to be biologically active in the literature like anti-microbial, anti-cancer, anti-inflammatory, antioxidant and so on. The present work focus on the synthesis of the biologically active compounds. Materials and Methods: Synthesis of the ligands and the complexes are done using the standard procedures in earlier reports. Melti Tetrazoloquinoxaline, Fused heterocycles, Anti-microbial, Flouresence, DNA, Cleavage, Cobalt metal complexes https://www.ijper.org/article/54/3/750-754 2026-04-13T05:54:56.122416+00:00 New Naphthyl Substituted Phytosterol and Lanostane Type-triterpenic Esters from the Stem Bark of Ficus religiosa L. 2020-08-22 10.5530/ijper.54.3.126 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-750.pdf Background: Ficus religiosa L. (Moraceae) is considered as a holy tree in most of the part of south-eastern Asia. Traditionally, its bark is used in the treatment of burns, diarrhoea, dysentery, gastrohelcosis and gonorrhoea, glandular swellings of the neck, scabies, piles, urogenital disorders, anxiety, vomiting, skin diseases and prescribed to improve the skin complexion. Materials and Methods: The methanol extract of stem bark of F. religiosa was obtained by continuous hot extraction process. Ficus religiosa, Stem bark, Phytosterol ester, Lanostanol ester, Isolation, characterization, β-sitosteryl naphthadiolyl linoleinate, Lanostanoic acid oleate https://www.ijper.org/article/54/3/509-516 2026-04-13T05:54:56.122416+00:00 Therapeutic Potential of Chymase Inhibitors in Cardiovascular Diseases: An Overview 2020-08-22 10.5530/ijper.54.3.99 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-509.pdf Chymase belongs to the family of serine proteases and is mainly warehoused in a heparin proteoglycan macromolecular complex within the mast cells. Extensive studies have been carried out in the last few decades to assess the role of chymase in human diseases. Recent studies have shown the significance of chymase in blood pressure regulation owing to its efficient angiotensin II forming activity. Angiotensin II-generation routes that are associated with human cardiovascular diseases have pathophy Chymase inhibitors, Angiotensin II, Angiotensin-converting enzyme, Mast, cells, Blood pressure regulator, Cardiovascular diseases https://www.ijper.org/article/54/3/755-760 2026-04-13T05:54:56.122416+00:00 Effect of Apricot Fruit and Kernel Extracts on in-vitro Dissolution of Cholesterol Gallstones: Implication for Development of Potent Anti-cholilithiaticc agent 2020-08-22 10.5530/ijper.54.3.127 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-755.pdf Prunus armeniaca L. (apricot) belonging to family Rosaceae is an important edible medicinal plant containing many important constituents like polysaccharides, polyphenol, fatty acid and carotenoids. In this study, we attempted to assess the in-vitro anti-gall bladder stones activity (anticholilithiatic activity) of Prunus armeniaca L. (apricot) kernel and fruit extracts. Methodology: For this study, some human gall bladder stones (cholesterol and pigment stones) along with human bile, were colle Cholelithiasis, Gallstones, Kernel, Ursodiol, Prunus armeniaca L https://www.ijper.org/article/54/3/637-646 2026-04-25T10:00:11.71636+00:00 Mupirocin Mounted Copper Nanoparticle Offered Augmented Drug Delivery against Resistant Bacteria 2020-08-22 10.5530/ijper.54.3.113 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-637.pdf Aim: In present investigation, mupirocin coupled copper nanoparticles were synthesized to overwhelm drug resistance in Staphylococcus aureus, responsible for dermal skin infections. Materials and Methods: Mupirocin (Anclaima Pvt. Ltd. India), copper sulphate (Thermo Fisher Scientific, India), Tri sodium citrate (Nice chemicals, India) Copper nanoparticles were produced by size reduction method by using Copper Sulphate and Tri sodium citrate. CuNPs were merged into gel base of carbopol which was Copper nanoparticle, Mupirocin, Carbopol gel, Antibacterial activity, Chemical, reduction method, Copper sulphate https://www.ijper.org/article/54/3/674-681 2026-04-25T10:02:46.385866+00:00 Naringin Attenuates Aluminum Induced Cognitive Deficits in Rats 2020-08-22 10.5530/ijper.54.3.117 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-674.pdf Aim: The exposure of aluminum for longer period in brain can lead to impaired cognition and behavioral changes. The present study was aimed to investigate the aluminum induced cognitive deficits and possible protective outcomes of naringin. Materials and Methods: Aluminum chloride in a dose of 100 mg/kg i.p was employed for 60 days to induce cognitive deficits in Westar rats. The animals were divided into groups each group contain six animals, as normal, aluminum treated, naringin treated (25, 5 Acetylcholine esterase, Aluminum, Alzheimer, Cognitive impairment, Oxidative stress, Naringin https://www.ijper.org/article/54/3/809-818 2026-04-27T04:38:19.282828+00:00 Dynamic Method for Liaison of Community Pharmacists with National Programme for Tuberculosis Control: Efforts to Harness Untapped Opportunities 2020-08-22 10.5530/ijper.54.3.133 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-809.pdf Context: Revised National Tuberculosis Control Program (RNTCP) - Directly Observed Treatment-Short course (DOTS) strategy to involve Community Pharmacist (CPs), was conceived and implemented in India, with the objective of improving accessibility of Tuberculosis free medicines. Though the RNTCP personnel in the study area had tried to create liaison with CPs; and to train them in DOTS provision roles, it was not successful as CPs were not forthcoming to be a part RNTCP - DOTS paradigm. Hence thi Tuberculosis, DOTS, Community Pharmacist, Public Private Mix Partnership, RNTCP, Public Health, DOTS Provider, National Programme https://www.ijper.org/article/54/3/589-601 2026-04-27T05:04:48.573072+00:00 Bioavailability and Dissolution Rate Enhancement of an Anticancer Drug Bicalutamide by Encapsulation into Mesoporous Silica Nanoparticles: Effects of Amine Functionalization and Caco-2 Cell Permeability Study 2020-08-22 10.5530/ijper.54.3.108 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-589.pdf Background: The present study was undertaken with the aim of dissolution rate and Bioavailability enhancement of anticancer drug Bicalutamide (BIC) via encapsulation into mesoporous silica nanoparticles (MSNs). Materials and Methods: The bare (MCM-41) and surface decorated MSNs were subjected to thorough characterization pre and post drug loading by Fourier transform infrared spectroscopy, Nitrogen sorption analysis, Differential Scanning Calorimetry, Thermogravimetric analysis, Small angle and Bicalutamide, Functionalized Mesoporous silica nanoparticles, Dissolution, Caco-2 cells permeability, Bioavailability https://www.ijper.org/article/54/3/496-508 2026-04-25T09:50:45.190187+00:00 Caspase Activators: Phytochemicals with Apoptotic Properties Targeting Cancer, a Health Care Strategy to Combat this Disease 2020-08-22 10.5530/ijper.54.3.98 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-496.pdf Context: Caspases, a family of cysteine-aspartic proteases have a pivotal role in apoptotic pathways. Their down-regulation is reported to induce inappropriate cell survival and enhanced carcinogenic potential. Screening of phytochemicals with a capacity to activate caspases enhancing apoptotic capacity has been proven to be effective anticancer agents. Objectives: This review consolidates data on phtochemicals traditionally used to treat cancerous conditions. The scientific validation of caspas Anticancer, Apoptosis-associated caspase assay, Advanced in silico, techniques, NCI, Kani tribes, HeLa cell lines https://www.ijper.org/article/54/3/618-629 2026-04-25T09:58:55.405211+00:00 Development and Evaluation of Unidirectional Mucoadhesive Bio-Flexy Films Loaded with Nanosized Topiramate using a Novel Biopolymer from Glycine max 2020-08-22 10.5530/ijper.54.3.111 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-618.pdf Aim: Formulation and evaluation of nanosized Topiramate loaded bio-flexy films using novel biopolymer isolated from Glycine max seeds for epilepsy treatment. Methods: Formulations containing nanosized Topiramate: Glycine max biopolymer (in ratios of 1:0.5, 1:1; 1:3, 1:5, 1:6, 1:10) (FGO1-FGO6) were prepared by solvent casting method. Results: Glycine max biopolymer showed percentage yield: 81.06%±0.01, light yellow, odorless, soluble in chloroform, water and color changing point: 218°C±2. Topira Unidirectional, Mucoadhesive, Bio-flexy films, Nanosized Topiramate, Soft, Palate, Glycine max biopolymer https://www.ijper.org/article/54/3/630-636 2026-04-25T09:59:28.37404+00:00 Molecular Interaction of Polymer Dextran in Sodium Hydroxide through Evaluation of Thermo Acoustic Parameters 2020-08-22 10.5530/ijper.54.3.112 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-3-630.pdf Aim: To find out the molecular interaction of solute dextran of different concentration with sodium hydroxide as a solvent. Materials: Dextran of molecular weight 70000 dalton and aqueous 1(N) Sodium hydroxide. Methods: To Measure the density by specific gravity bottle, Viscosity by Ostwald’s viscometer and ultrasonic velocity through ultrasonic interferometer of the solution and to calculate the thermo acoustical parameters using the measured parameters. Results: Ultrasonic wave propagation aff IJPER, Citation profile, Scientometrics, Pharmaceutics, Journal evaluation https://www.ijper.org/article/54/2s/s344-s349 2026-04-25T09:41:23.617516+00:00 Stability Indicating RP-HPLC Method Development and Validation for the Quantification of Obeticholic Acid in Bulk and its Pharmaceutical Dosage Form 2020-05-05 10.5530/ijper.54.2s.92 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-344.pdf Aim and Objectives: The aim of present research work is to develop stability indicating validated RP-HPLC method for the quantification of Obeticholic acid in bulk and its pharmaceutical dosage form. Materials and Methods: Chromatographic method was carried on C18 column (Ascentis 150mm x 4.6 mm, 5m). Mobile phase was prepared by mixing 0.1% OPA: Acetonitrile in the ratio of 60:40. The flow rate was 1.0 mL/min and the injection volume was 10 μL. The absorbance maxima of obeticholic acid was meas Obeticholic acid, RP-HPLC method, 0.1% OPA, Acetonitrile, Validation, ICH, guidelines https://www.ijper.org/article/54/2s/s368-s373 2026-04-25T09:45:37.411822+00:00 Simultaneous RP-HPLC Quantification of Four Phenolics in Elephantopus scaber L. and their in vitro Pharmacological Validation 2020-05-05 10.5530/ijper.54.2s.95 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-368.pdf Elephantopus scaber (L.) is a widely used traditional medicinal plant, grows in hotter parts of the Indian subcontinent, Tropical Africa and East Asia. The present study was aimed RPHPLC quantification of phenolics and its pharmacological validation in Elephantopus scaber (L.). The chromatographic separation was obtained using RP-C18 column, using mobile phase acetic acid: water (1.0: 99.0 V/V) as solvent-A and acetonitrile as solvent-B and 0.6ml/min flow rate was used for proper separation. HPL Antidiabetic, Antioxidant, Elephantopus scaber, Phytochemical, RP-HPLC https://www.ijper.org/article/54/2s/s210-s219 2026-04-25T05:28:04.219432+00:00 Xyloglucan Based Nasal in situ Gel Formulation of Mirtazapine for Treatment of Depression 2020-05-05 10.5530/ijper.54.2s.77 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-210.pdf Objectives: The objective of the present work was formulation of thermosensitive mucoadhesive in situ nasal gel of Mirtazapine for depression. The nasal route would overcome the first-pass effect and would enhance its efficacy. Methods: The thermally triggered in situ nasal gel was prepared by cold method using Poloxamer 407 and Xyloglucan. Formulation batches of in situ gel were prepared by using 32 full factorial design. The in situ gel was evaluated for gelling temperature, % drug content, ex In situ nasal gel, Poloxamer 407, Xyloglucan, Mirtazapine, Mucoadhesive, Depression, Gelling temperature. https://www.ijper.org/article/54/2s/s56-s66 2026-04-13T05:54:57.0684+00:00 A Paradoxically Significant Medicinal Plant Carapichea ipecacuanha: A Review 2020-05-05 10.5530/ijper.54.2s.61 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-56.pdf Background: Carapichea ipecacuanha (Brot.) L. Andersson is the botanical source of Ipecac drug and contains major alkaloids emetine, cephaline that are pharmaceutically used against bronchitis associated with cough in children, severe diarrhea (amoebic dysentery) and also cancer. Ipecac serves as an expectorant to thin mucous and easy coughing. Low doses are used to enhance appetite and it is administered orally to cause vomiting after suspected poisoning. Materials and Methods: The review highl Carapichea ipecacuanha, Taxonomy, Distribution, Pharmacology, Medicine https://www.ijper.org/article/54/2s/s277-s284 2026-04-25T05:31:35.84707+00:00 Effect of Gymnema sylvestre on Insulin Receptor (IR) and Proglucagon Gene Expression in Streptozotocin Induced Diabetic Rats 2020-05-05 10.5530/ijper.54.2s.84 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-277.pdf Aim: To study the expression of Insulin Receptor (IR) in pancreas and proglucagon in the ileum homogenate with the hydroalcoholic extract of Gymnema sylvestre (HAGS) in streptozotocin induced diabetic rats. Materials and Methods: The HAGS was administered once daily at 100, 200 and 400mg/kg bd.wt for 28 days to STZ induced diabetic rats. Blood samples were collected at the end of 28 days. Serum blood glucose, glycosylated hemoglobin (HbA1c), insulin levels; SOD (Superoxide Dismutase), CAT (Catal Diabetes, Gymnema sylvestre, Proglucagon, Insulin, GLP-1, Insulin Receptor https://www.ijper.org/article/54/2s/s301-s308 2026-04-25T05:33:21.097943+00:00 Bioassay-Guided Fractionation of Endophytic Fungal Extract of Fusarium solani (Saccardo) against Cancer Cell Lines and Zebrafish Embryo 2020-05-05 10.5530/ijper.54.2s.87 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-301.pdf Background: This study aimed to explore the toxicity and apoptotic potential of Fusarium solani extracts on cancer cell lines and zebrafish embryo. Materials and Methods: F. solani was initially extracted with ethyl acetate and methanol. Further purification was performed using column chromatography. Each fraction was assayed for its cytotoxic potential against four cancer cell lines using MTT assay. The apoptotic potential of the HepG2 cells was investigated using Hoechst 33342 dye and caspase Cell lines, Endophyte, Fusarium solani, Toxicity, Zebrafish https://www.ijper.org/article/54/2s/s269-s276 2026-04-13T05:54:57.0684+00:00 Antifungal Nail Lacquer Loaded with Extract of Cissus quadrangularis for Treatment of Onychomycosis 2020-05-05 10.5530/ijper.54.2s.83 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-269.pdf Objectives: An attempt was made to prepare transparent nail lacquer containing natural antifungal agent obtained from extract of whole plant of Cissus quadrangularis for the treatment of onychomycosis. Methods: The extract of C. quadrangularis was evaluated for antifungal study against Candida albicans. Minimum inhibitory concentration of extract against C. albicans was performed to get the amount of extract to be loaded in the nail lacquer. Extract was further evaluated for phytochemical study Onychomycosis, Cissus quadrangularis, Transungual, Nail lacquer, Antifungal https://www.ijper.org/article/54/2s/s182-s188 2026-04-25T05:26:20.474215+00:00 Synthesis and Characterization of Un-encapsulated and Pterostilbene-encapsulated DOTAP: Cholesterol Liposomes 2020-05-05 10.5530/ijper.54.2s.74 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-182.pdf Aim: Our study focuses on the liposome-based nanoformulation, which can encapsulate Pterostilbene for its subsequent testing in relevant, model systems for cancer. Background: Pterostilbene, a plant-derived, hydrophobic, dietary stilbenoid, has been studied for its ability to induce cell death and regulate caspases in the different types of cancer cells. The potential of this drug can be improved by formulating a suitable vehicle for its delivery. Biocompatible, lipid-based nanoparticles called Pterostilbene, DOTAP, Cholesterol, Liposomes, Nanoparticles. https://www.ijper.org/article/54/2s/s98-s107 2026-04-25T05:23:17.840315+00:00 Development of Taste Masked Orodispersible Film Containing Paroxetine Hydrocloride 2020-05-05 10.5530/ijper.54.2s.66 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-98.pdf Aim and Objectives: The present study was to formulate and evaluate orodispersible films to overcome drawbacks of conventional dosage forms such as degradation by first-pass hepatic metabolism, decreased bioavailability and patient non-compliance. In the present work the taste masked Paroxetine HCl was formulated in the form of Orodispersible film. Rationale for formulating the taste masked PXT in ODF form was to increase convenience of paediatric, geriatric, bedridden, psychiatric patients and Paroxetine hydrochloride, Hydroxy Propyl Beta Cyclodextrin, Taste-masking, Freeze-drying, Oral films. https://www.ijper.org/article/54/2s/s43-s55 2026-04-25T05:19:43.194913+00:00 Caspase Activators: Phytochemicals with Apoptotic Properties Targeting Cancer, A Health Care Strategy to Combat this Disease 2020-05-05 10.5530/ijper.54.2s.60 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-43.pdf Context: Caspases, a family of cysteine-aspartic proteases have a pivotal role in apoptotic pathways. Their down-regulation is reported to induce inappropriate cell survival and enhanced carcinogenic potential. Screening of phytochemicals with a capacity to activate caspases enhancing apoptotic capacity has been proven to be effective anticancer agents. Objectives: This review consolidates data on phtochemicals traditionally used to treat cancerous conditions. The scientific validation of caspas Anticancer, Apoptosis-associated caspase assay, Advanced in silico techniques, NCI, Kani tribes, HeLa cell lines. https://www.ijper.org/article/54/2s/s189-s199 2026-04-13T05:54:57.0684+00:00 Lipid-Based Nano Formulation Approach to Target Brain for the Management of Tuberculosis through Intranasal Delivery: Formulation Development and Evaluation 2020-05-05 10.5530/ijper.54.2s.75 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-189.pdf Objectives: Development of nano-emulsion based drug delivery as combined drug loaded form for the possible management of meningitis. Intranasal delivery of nano-emulsion to the brain and study the nasal irritancy. Methodology: Spontaneous emulsification method was used in preparing the nanoemulsion. The compatibility studies i.e., Differential Scanning Colorimetry and Fourier Transform Infrared Spectroscopy were carried out for Isoniazid, Rifampicin, Resveratrol and physical mixture. Pseudoterna Tuberculous meningitis, Intranasal delivery, Nanoemulsion, Blood Brain, Barrier, Mycobacterium tuberculosis https://www.ijper.org/article/54/2s/s12-s18 2026-04-13T05:54:57.0684+00:00 Modified Pectins for Colon-Specific Drug Delivery 2020-05-05 10.5530/ijper.54.2s.57 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-12.pdf Treatment of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome and colonic cancer by targeting drug to the colon is a viable approach. Due to gastric degradation of drugs, proteins and peptides, only minimum amount of drug gets absorbed when administered orally and shows little therapeutic activity. Hence the strategy of delivering drugs to colon known as colon targeted drug delivery evolved. Pectin a naturally occurring biodegradable polysaccharide has gained Colon targeting, Intestinal microflora, Modified pectin forms, Gelling property, biodegradable polysaccharide, Drug delivery https://www.ijper.org/article/54/2s/s337-s343 2026-04-25T05:36:23.842198+00:00 Ultraviolet-visible Spectrophotometric Method for Estimation of Gliclazide in Presence of Excipients Interacting in UV-visible Region 2020-05-05 10.5530/ijper.54.2s.91 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-337.pdf A simple and sensitive ultraviolet spectrophotometric method for quantitative estimation of a model API gliclazide in presence of excipients is described to avoid false estimation due to presence of soluble or insoluble impurity. UV detection was performed at 226 nm, 221 nm and 231 nm and the calibration curve was prepared between the resultant of absorbance at these three wavelengths according to the equation [226 nm - (221 nm + 231 nm)/2] and the concentration of gliclazide. The calibration cu Pure, Impure, Excipients, UV spectrophotometric method, Gliclazide https://www.ijper.org/article/54/2s/s309-s315 2026-04-13T05:54:57.0684+00:00 New Bioactive Molecules Isolated for the First Time from Hyoscyamus albus L. and their Mechanisms Underlying the Anticancer Effects 2020-05-05 10.5530/ijper.54.2s.88 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-309.pdf Background: Hyoscyamus albus L is a small genus from Solanaceae family known by its use in old traditional medicine in the east of Algeria. Aim: This study aimed to characterize new bioactive molecules from H. albus, evaluate their anticancer activity in several cancer cells and investigate their possible molecular mechanism. Materials and Methods: New compounds (Peak h of fraction F), (Peak 3 of Fraction F), (Peak 1 of fraction C) were isolated from H.albus L. byusinghigh-performance chromatogr Hyoscyamus albus L, Solanaceae, HPLC, Cytotoxic activity, HAMeOH, NMR H1, Annexine V, Apoptosis https://www.ijper.org/article/54/2s/s75-s78 2026-04-25T05:21:37.961753+00:00 Upskilling of Pharmacy Faculty in an Accredited Institution through Modular Training in Strategic Education Practices with Formative and Summative Assessments 2020-05-05 10.5530/ijper.54.2s.63 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-75.pdf Aim: To study the impact of Modular Faculty training on the attitude of faculty, motivation towards self–directed learning and team learning. Train the faculty on new teaching and learning tools and assessment. Assess the faculty continuously and after the completion of the training and distribute certificates as per the requirements informed in advance. Materials and Methods: Thirty two (32) faculty of an accredited college were enrolled in a 4 credit course consisting of 15 Modules with 60 con Up-skilling, Strategic Education Practices, Modular training and Assessment, Grading, MCQ and RRE. https://www.ijper.org/article/54/2s/s154-s162 2026-04-13T05:54:57.0684+00:00 Development of Thermosensitive Ophthalmic in situ Gels of Bimatoprost for Glaucoma Therapy 2020-05-05 10.5530/ijper.54.2s.71 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-154.pdf Background: In recent years, ophthalmic in situ gels have gained wide importance for the sustained delivery of drugs into the eye by overcoming the demerits of conventional eye drops. Objectives: The present investigation was undertaken to formulate and evaluate Bimatoprost loaded thermosensitive ophthalmic in situ gels for providing prolonged drug release pattern with good patient acceptance. Methods: Bimatoprost thermosensitive ophthalmic in situ gels were prepared by the cold method using tem Bimatoprost, Poloxamer 407, In situ gels, Viscosity, Isotonicity https://www.ijper.org/article/54/2s/s374-s380 2026-04-13T05:54:57.0684+00:00 Clot Buster Enzyme Activity from Bacillus sp., 2020-05-05 10.5530/ijper.54.2s.96 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-374.pdf Context: Clot buster enzyme is widely used as the thrombolytic agent due to its low cost as compared to several other thrombolytic agents. Aim: The aim of the study is to isolate clot buster enzyme producing bacteria from soil sample. Materials and Methods: In the present study, we have isolated 20 different bacterial strains from soil source collected near meat shops and screened for the production of clot buster enzymes. The sample was serially diluted and characterized in the Bacillus differe Cardiovascular, Clot buster, Casein hydrolysis, SDS-PAGE, HPLC https://www.ijper.org/article/54/2s/s19-s31 2026-04-25T05:15:19.883512+00:00 Comparability Pathway for the Approval of Similar Biologics with Respect to Reference Biologics in Europe and Brazil 2020-05-05 10.5530/ijper.54.2s.58 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-19.pdf The regulatory environment for biologics is continuously evolving, because they are ensuring the targeted therapies for many dreadful diseases. But the high cost of biologics has made the European Union to go for the biosimilar development for the first time after the expiration of patents. The strict requirements by the European Medicines Agency (EMA) guaranteed the highest quality standards. These biosimilars are complex in nature and difficult to characterize because they are extracted from t Biologics, biosimilars, EMA, ANVISA, comparability, International nonproprietary name Partnership for productive development. https://www.ijper.org/article/54/2s/s108-s116 2026-04-13T05:54:57.0684+00:00 Development and Optimization of Naproxen Sodium Controlled Release Tablets: QbD Approach 2020-05-05 10.5530/ijper.54.2s.67 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-108.pdf Objectives: The aim of present study was to formulate and optimize Multi-unit Naproxen Sodium controlled release tablet by QbD approach. Controlled release dosage form for naproxen sodium was selected to reduce dosing frequency and gastrointestinal side effects of drug. Methods: Naproxen Sodium CR tablets were prepared by using wet granulation method by employing Quality by Design (QbD). This tablet was made by a mixture of a granulate having an immediate release with a granulate having a contro Multi-unit-controlled release system, Quality by Design, Design of experiment, Eudragit RLPO, Eudragit RSPO https://www.ijper.org/article/54/2s/s316-s329 2026-04-13T05:54:57.0684+00:00 Structural Elucidation of Isolated Phytochemicals from Selected Medicinal Plants with Antihyperlipidemic Activity and Development of Polyherbal Formulation with Densitometric Analysis of Isolated Phytoconstituents 2020-05-05 10.5530/ijper.54.2s.89 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-316.pdf Objectives: The present systematic research aimed to express the antihyperlipidemic effects of different types of herbs based on animal studies. The purpose of the present project is to perform the phytochemical investigation and exploration of hypolipidemic activity with the development and quantification of phytoconstituents of polyherbal hypolipidemic formulation employing Apium graveolens, Salvadora persica, Carica papaya and Evolvulus alsinoides. Materials and Methods: Flash chromatography Hyperlipidemia, Medicinal Plants, Flash Chromatography, Isolated, Phytoconstituents, HPTLC Densitometric Analysis https://www.ijper.org/article/54/2s/s117-s127 2026-04-13T05:54:57.0684+00:00 Formulation and Evaluation of Nisoldipine Loaded Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Application to Transdermal Delivery 2020-05-05 10.5530/ijper.54.2s.68 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-117.pdf Background: Nisoldipine is an anti hypertensive drug. Nisoldipine exhibits poor oral bioavailability (5%) because of rapid metabolism in the gut and liver. To overcome hepatic first pass metabolism and to enhance bioavailability, lipid based drug delivery systems (Solid lipid nanoparticles (SLN) and nano structure lipid carriers (NLC)) can be exploited. Objectives: In this work, effort was made to prepare novel particulate carrier systems such as stable Solid Lipid Nanoparticles and Nanostructur Nisoldipine, Solid lipid nanoparticles, Nanostructured lipid carriers, In-vitro, release studies, Ex-vivo permeation studies, Lyophilization https://www.ijper.org/article/54/2s/s163-s172 2026-04-13T05:54:57.0684+00:00 Development of Natamycin Loaded Glycerosomes–A Novel Approach to Defend Ophthalmic Keratitis 2020-05-05 10.5530/ijper.54.2s.72 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-163.pdf Objectives: Glycerosomes represent novel drug delivery systems and are characterised by addition of different amounts of glycerol to liposomal preparations. The present research work aims to formulate eyedrops of natamycin loaded glycerosomes and thereby improve its entrapment efficiency in the vesicles and enhance its corneal penetration. Methods: Liposomes and glycerosomes loaded with antifungal drug, natamycin, were prepared by thin film hydration technique and the prepared glyerosomes were o Glycerosomes, Thin Film Hydration, Optimization, Factorial Design, Ocular, Ex vivo https://www.ijper.org/article/54/2s/s200-s209 2026-04-13T05:54:57.0684+00:00 Formulation and in-vitro Evaluation of Oral Captopril Bioadhesive Delivery System 2020-05-05 10.5530/ijper.54.2s.76 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-200.pdf Background: Captopril is considered as the drug of choice in the treatment of hypertension and congestive heart failure. It has a very short duration of action and a biological half-life of 1-2 hr. This requires its administration in 2-3 times daily which is not convenient for the management of a chronic disease like hypertension. Objectives: Captopril is unstable at the alkaline pH of the gastrointestinal tract. Therefore, it is difficult to be delivered orally in a sustained release formulatio Chitosan, Microspheres, Bioadhesion, Captopril, In-vitro release https://www.ijper.org/article/54/2s/s220-s229 2026-04-13T05:54:57.0684+00:00 Supramolecular Complexes of Phospholipids and β-Cyclodextrin with Bioactive β-Carotene: A Comparative Physico-Chemical and Functional Evaluation 2020-05-05 10.5530/ijper.54.2s.78 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-220.pdf Background: β-carotene, a chief component of carotenoids family exhibits multiple numbers of pharmacological activities. However, its poor aqueous solubility and low dissolution rate restricts it to become a potential drug candidate. Hence, β-carotenephospholipids complex (BPLC) and β-carotene-β-cyclodextrin complex (BCDC) were prepared with an objective of enhancing its aqueous solubility and dissolution rate. Materials and Methods: BPLC and BCDC were synthesized using solvent evaporation and k β-carotene, Phospholipids, β-cyclodextrin, Solubility, in vitro dissolution https://www.ijper.org/article/54/2s/s261-s268 2026-04-13T05:54:57.0684+00:00 In-vivo Screening of Ethanolic Extract of Antigonon leptopus Flower for Anti-diabetic and Antioxidant Potential 2020-05-05 10.5530/ijper.54.2s.82 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-261.pdf Objectives: Medicinal plants have always been a consummate source for drugs and already provided us with lead compounds for numerous currently available drugs with no or less side effects. This supports the usage of herbal drugs for the treatment and management of various diseases. However, an assessment with available techniques has become an essential aspect to establish a valid scientific rationale for their usage in major healthcare problems. Methods: Ethanolic extract of Antigonon leptopus Antigonon leptopus, Anti-diabetic, Antioxidant, Hypolipidemic, DPPH https://www.ijper.org/article/54/2s/s79-s87 2026-04-13T05:54:57.0684+00:00 2,4-Dichlorophenoxy Acetic Acid as an Antidiabetic Drug: In silico, Preformulation and in vivo Approaches 2020-05-05 10.5530/ijper.54.2s.64 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-79.pdf Background: 2,4-Dichlorophenoxy acetic acid (2,4-D) was recently rediscovered as new anti-inflammatory agent through an in silico molecular modeling and in vivo anti-inflammatory inspection. Further computational investigations showed very close similarity between 2,4-D and pioglitazone in the mode of binding to PPARγ ligand binding pocket, suggesting an antidiabetic activity. Aim: To evaluate the binding strength of 2,4-D to PPARγ binding pocket and to improve the low water solubility of 2,4-D 2, 4-D, Micronized, Pioglitazone, Repositioning, Streptozotocin https://www.ijper.org/article/54/2s/s173-s181 2026-04-13T05:54:57.0684+00:00 Isoxsuprine Hydrochloride Loaded Cellulose Acetate Phthalate Microsponge Drug Delivery System: Design and Evaluation 2020-05-05 10.5530/ijper.54.2s.73 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-173.pdf Aim: The present study was aimed to Design and evaluation of microsponge based drug delivery system of Isoxsuprine Hydrochloride. The microsponge drug delivery system is designed for site specific and controlled release of drug by using cellulose acetate phthalate to improve the site-specific absorption of drug. Materials and Methods: The microsponges was formulated by modified quasi emulsion solvent diffusion technique. The chemical interaction between Isoxsuprine Hydrochloride, cellulose aceta Microsponges, Isoxsuprine Hydrochloride, Cellulose acetate phthalate, Quasi, emulsion solvent diffusion, Site specific absorption https://www.ijper.org/article/54/2s/s88-s97 2026-04-13T05:54:57.0684+00:00 Design Development and Characterisation of Tramadol Hydrochloride Loaded Transethosomal Gel Formulation for Effective Pain Management 2020-05-05 10.5530/ijper.54.2s.65 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-88.pdf Introduction: The purpose of the present study was to design develop and characterize the tramadol hydrochloride loaded transethosomal gel formulation for effective pain management. Materials and Methods: The transethosomes were prepared by simple cold method. Total 12 formulations were prepared using different concentrations of phospholipid (Soya lecithin and L-α Phosphatidylcholine from egg yolk) and edge activator (Span 20 and Cremophor EL 35).The developed transethosomes were characterized f Transethosomes, Tramadol hydrochloride, Phospholipid, Edge activator, Entrapment efficiency https://www.ijper.org/article/54/2s/s350-s357 2026-04-25T09:42:32.62503+00:00 Development and Validation of Novel Stability- Indicating LC Method for the Determination of Saxagliptin and Metformin 2020-05-05 10.5530/ijper.54.2s.93 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-350.pdf Aim: Development of a novel precise, selective and sensitive stability indicating RPHPLC method has been developed and validated for the determination of Saxagliptin hydrochloride (SAX) and Metformin HCl (MET) in bulk drug and pharmaceutical dosage form. Materials and Methods: The separation was carried out on a Phenomenex Luna, SCX, 250 x 4.6mm, 10 μm using a mobile phase of ammonium dihydrogen phosphate buffer pH 2.50: methanol [70:30 % v/v]. Quantitation was achieved using UV detection at 210 Saxagliptin, Metformin, Stability indicating, Forced degradation, Pharmaceutical preparation https://www.ijper.org/article/54/2s/s32-s42 2026-04-13T05:54:57.0684+00:00 Lipid Nanocarriers: Promising Approach for Oral Drug Delivery System 2020-05-05 10.5530/ijper.54.2s.59 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-32.pdf Background: A suitable drug delivery system has been work on the strategy to enable safe and effective therapeutic efficacy. Drug discovery program, it has huge number of drug molecules are lipophilic as poor aqueous soluble. Oral drug delivery system is a safe, convenient and easy route for drug administration. Bioavailability is a major issue. Drug administrated with low bioavailability may lead to an ineffective therapeutic efficacy and several adverse effects. However, there are several reas Lymphatic system, Liposome, Solid lipid nanoparticle, Self-nanoemulsifying, Nanostructural lipid carrier https://www.ijper.org/article/54/2s/s1-s11 2026-04-13T05:54:57.0684+00:00 Supercritical Fluid Technology and its Pharmaceutical Applications: A Revisit with Two Decades of Progress 2020-05-05 10.5530/ijper.54.2s.56 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-1.pdf Over the past two decades, supercritical fluid technology has emerged as one of the most important technologies applied in many fields such as cosmetic, food and pharmaceutical. Supercritical fluid extraction process offers numerous advantages such as easy, effective, inexpensive, high quality of solute extraction and environmentally friendly. This mini-review describes the fundamentals of supercritical fluid technology, the function of supercritical fluid as solvent and anti-solvent, mechanism Bioavailability enhancement, Biomedical applications, Drug delivery, Polymeric, carriers, Supercritical fluids https://www.ijper.org/article/54/2s/s140-s153 2026-04-13T05:54:57.0684+00:00 In vitro and in vivo Exploration of Super-magnetically Modulated Novel Parenteral Carrier: A Targeted Drug Delivery of Polymeric Carboplatin Nanosphere Capped with the Vitamin C to Treat Breast Cancer in Rats 2020-05-05 10.5530/ijper.54.2s.70 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-140.pdf Introduction: Super-magnetically modulated nanosphere of carboplatin (CPt) capped with vitamin C and uncapped Nano sphere of CPt were developed and evaluated for their use as a targeted drug delivery system. Objectives: The objective of the study was to encounter multiple problems such as to circumvent the snag caused by the larger molecules, increase the target ability of magnetic particle and synergize the impact of carboplatin with antioxidant effect. Methods: Particulate carriers for magneti Carboplatin, Ethyl cellulose, Magnetite, Vitamin C, Nanopshere https://www.ijper.org/article/54/2s/s67-s74 2026-04-13T05:54:57.0684+00:00 Apple Cider Vinegar (ACV) and their Pharmacological Approach towards Alzheimer’s Disease (AD): A Review 2020-05-05 10.5530/ijper.54.2s.62 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-67.pdf Alzheimer's disease (AD) is a neurological degenerative condition described by a progressive decline in memory and associated with dementia. This disease arises usually after 65 years in individuals. Oxidative stress is the major cause of dementia connected with Alzheimer's disease. Here there is an imbalance between the creation and clearance of amyloid β protein, which leads to accumulation of amyloid β plaque in the brain and produces neuronal cell death. Anti-Alzheimer's medications help to Apple Cider Vinegar, Alzheimer’s disease, Oxidative stress, Phenolic, compounds, Aβ aggregation, Pharmacological activities https://www.ijper.org/article/54/2s/s358-s367 2026-04-13T05:54:57.0684+00:00 Development and Validation of a Simultaneous Bioanalytical Method for Methotrexate, Sulfasalazine and Hydroxychloroquine in Rat Plasma following Single Step Protein Precipitation Technique 2020-05-05 10.5530/ijper.54.2s.94 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-358.pdf Background: Triple therapy of methotrexate, sulfasalazine and hydroxychloroquine is widely used in the treatment of rheumatoid arthritis. Different studies reported the superior efficacy of combination of these three drugs in the improvement of this disease state. However, there is still a lot of scopes remains for preclinical study of this combination in future. Establishment of bioanalytical method is essential for quantitating these analytes in the samples from such types of studies. Therefor Methotrexate, Sulfasalazine, Hydroxychloroquine, Bioanalytical method, development and validation, Pharmacokinetic application https://www.ijper.org/article/54/2s/s128-s139 2026-04-13T05:54:57.0684+00:00 Formulation and Evaluation of Asenapine Maleate Loaded Niosomes for the Treatment of Schizophrenia 2020-05-05 10.5530/ijper.54.2s.69 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-128.pdf Background: Niosomes are the non-ionic surface-active agent primarily based vesicles. The Key obstacle of Asenapine maleate have oral bioavailability (<2%) and extensive first pass effect. Objectives: The objective key of the existing work was to formulate Asenapine maleate loaded niosomes using quality by design and rectify it with some evaluation parameters to increase bioavailability, to lead better therapeutic effect and to minimize the side effects. Methods: Formulation of niosomes was done IJPER, Citation profile, Scientometrics, Pharmaceutics, Journal evaluation https://www.ijper.org/article/54/2s/s330-s336 2026-04-13T05:54:57.0684+00:00 Total Synthesis of Clausenain, a Cyclic Octapeptide and its Analog for Anticancer Activity 2020-05-05 10.5530/ijper.54.2s.90 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-330.pdf Keeping in mind requisite of today’s era for development of new anticancer drugs, synthesis of a phenyl alanine rich cyclic octapeptide Clausenain and its analog by solution phase technique is described here. It was done through coupling a tetrapeptide BOC-Phe-Ser-Leu-Phe–OMe with another tetrapeptide BOC-Phe-Gly-Leu-Phe-OMe after proper deprotection towards carboxyl and amino terminals. The N-methyl analog of this octapeptide was prepared with N-methylated Glycine instead of Glycine as starting Octapeptide, Solution phase technique, p-nitro phenyl ester method, Brine, shrimp, Anticancer, Tumor cell lines https://www.ijper.org/article/54/2s/s241-s250 2026-04-13T05:54:57.0684+00:00 Comparison of Release Retardant Effect of Some Novel Lipids by Formulating Sustained Release Tablet of BCS Class 1 Drug 2020-05-05 10.5530/ijper.54.2s.80 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-241.pdf Aim: The study was carried out with the objective of comparing the release retardant effect of some novel lipids by preparing sustained release tablets of highly watersoluble drug, theophylline. Methods: The tablets were a mixture of theophylline and each of the three novel lipids taken in different ratios (Compritol ATO 888, Precirol ATO 5, Dynasan 114) prepared by Direct compression method. Drug and novel lipids interaction was determined by FTIR spectroscopy and DSC while drug release from th Theophylline, Direct Compression, Sustained Release, Compritol ATO 888, Precirol ATO 5, Dynasan 114 https://www.ijper.org/article/54/2s/s285-s294 2026-04-13T05:54:57.0684+00:00 Neuroprotective Effects of Licorice Extracts in Tibial and Sural Transection Induced Neuropathic Pain in Rats 2020-05-05 10.5530/ijper.54.2s.85 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-285.pdf Background: Neuropathic pain (NP) is the worst of tortures, a nerve wound may experience as a result of nerve damage or complication of diabetes/HIV/cancer. There are no defined guidelines for treatment. Available treatments have various side effects. Glycyrrhiza glabra (Licorice) has not been explored scientifically with respect to NP. Hence there is a dire need to develop treatment for NP which will be safe, effective and can be taken for prolonged time. The present study is to evaluate effect Glycyrizza glabra, Neuropathic pain, Tibial and Sural Transection, Antioxidant, Licorice root, Antiinflammatory https://www.ijper.org/article/54/2s/s295-s300 2026-04-13T05:54:57.0684+00:00 In-vitro Cytotoxicity and in silico Molecular Docking of Alkaloids from Tiliacora acuminata 2020-05-05 10.5530/ijper.54.2s.86 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-295.pdf Background: The present study aimed to identify the cytotoxicity of Tiliacora acuminata extract/fraction(s) plant via bioactivity guided approach and predict the binding affinity with Topoisomerase II. Materials and Methods: Extract and fractions were screened using brine shrimp lethality bioassay and the potent fraction was further evaluated for its in vitro cytotoxicity using five different cell lines i.e. HT-29, HepG2, MCF-7 and A-549. The binding affinity of individual phytoconstituent from Alkaloids, Brine shrimp, Docking, Menispermaceae, MTT, Topoisomerase II https://www.ijper.org/article/54/2s/s230-s240 2026-04-25T05:28:58.246661+00:00 Tenofovir Loaded Poly (Lactide-Co-Glycolide) Nanocapsules: Formulation Optimization by Desirability Functions Approach 2020-05-05 10.5530/ijper.54.2s.79 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-230.pdf Background: Nanoparticles made of biodegradable polymers are the most effective colloidal drug delivery systems. The in vitro characteristics as well as in vivo presentation of these nanoparticles are majorly influenced by their formulation parameters. Objectives: The principle objective of the work was to optimize various critical formulation parameters by using statistical tools in order to develop poly (lactide-co-glycolide) (PLGA) nanocapsules loaded with tenofovir disoproxil fumarate (TDF) Tenofovir, Nanocapsules, Optimization, Response surface methodology, Desirability functions approach. https://www.ijper.org/article/54/2s/s251-s260 2026-04-25T05:30:13.549903+00:00 In vitro Anthelmintic Impact of Various Extracts of Pavetta tomentosa Root on Pheretima posthuma and in-silico Molecular Docking Evaluation of some Isolated Phytoconstituents 2020-05-05 10.5530/ijper.54.2s.81 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2s-251.pdf Background: The current study assesses the anthelmintic impact of root extracts of Pavetta tomentosa on Pheretima posthuma compiled by molecular docking analysis of phytocompounds steemed from the plant with the β-Tubulin (PDB ID: 1SA0). Methods: In this study, P. tomentosa root was subjected to extraction using methanol and water. In vitro, anthelmintic activity was assessed by utilizing the Pheretima posthuma and in silico molecular docking was executed making use of Autodock 4.0. Results: The In-silico, Autodock 4.0, Pavetta tomentosa, β-eudesmol, Albendazole, ADME/T https://www.ijper.org/article/54/2/385-396 2026-04-13T05:54:57.875565+00:00 In vitro Evaluations of Biodegradable Polyacrylamide Grafted Moringa Bark Gum Graft Copolymer (MOG-g- PAAM) as Biomedical and Controlled Drug Delivery Device Synthesized by Microwave Accelerated free Radical Synthesis 2020-03-12 10.5530/ijper.54.2.44 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-385.pdf Aim: The present work is based on preparation of different grades of Moringa Bark Gum (MOG) with Acrylamide (AM) with varying amount of AM (monomer) and APS (redox initiator) using microwave accelerated free radical reaction. Objectives: In the current work, the Moringa bark gum grafted with acrylamide graft copolymer was tested for tissue engineered polymeric scaffold as well as controlled drug delivery system using metronidazole as a model drug. Methodology: The microwave radiation process was Graft Copolymer, Metronidazole, Moringa Gum, Microwave Irradiation, Biodegradability, Controlled drug release, Polymeric scaffold, Histopathology https://www.ijper.org/article/54/2/376-384 2026-04-13T05:54:57.875565+00:00 Development and Optimization of Capecitabine loaded Nanoliposomal System for Cancer Delivery 2020-03-12 10.5530/ijper.54.2.43 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-376.pdf Objectives: The Main objective of this study was to develop and optimize Capecitabine loaded nanoliposomes for prolonged drug delivery in cancer treatment. Methods: Liposomes were prepared by the thin film hydration method followed by sonication. The parameters affecting the vesicle size and percentage drug entrapment of liposome are amount of soyaphosphatidyl choline and cholesterol used in their preparation. The Capecitabine liposomal formulation was optimized using 32 factorial design in this Capecitabine, Liposome, 32 Factorial design, Percent drug entrapment, Release kinetics https://www.ijper.org/article/54/2/432-439 2026-04-13T05:54:57.875565+00:00 N-(2-(1H-benzo[d]imidazol-2-yl)Phenyl)-2- (Substituted-styryl)Aniline as Anti-proliferative Agents: Rejuvenating the Importance of Low Molecular Weight Ligands in Oncotherapeutics 2020-03-12 10.5530/ijper.54.2.49 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-432.pdf Background: The rationale behind the study involved that in individuality benzimidazolebased molecules demonstrates significant anti-proliferative activity; chalcone molecules like xanthohumol are known to express noteworthy anti-cancer activity; benzamide derived products show remarkable inhibition of HDAC (an emerging anti-proliferative target) and styrene-based compounds possesses notable anti-tumor activity. Materials and Methods: In this research, an attempt was made to synthesize and chara Benzimidazole, Benzamide, Styryl, Chalcone, Hybrid, Anti-proliferative https://www.ijper.org/article/54/2/456-464 2026-04-13T05:54:57.875565+00:00 Robust Analytical Method for Iron Estimation by Experimental Design Approach 2020-03-12 10.5530/ijper.54.2.52 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-456.pdf Aim: To perform Iron estimation by UV-Visible spectroscopy using an Experimental design approach. Objectives: The robust analytical method was developed for the estimation of iron (III) using 1, 10-phenanthroline reagent. Methods: The analytical method is an exploration of the chemical reaction of iron with 1, 10- phenanthroline reagent to form a colored complex which was measured in the UV-Visible region at 509 nm. To monitor the effect of diverse factors like the concentration of reagent (A), Iron sucrose, 1, 10- Pheanthroline, Full factorial design, Box-Behnken design https://www.ijper.org/article/54/2/293-301 2026-04-13T05:54:57.875565+00:00 Formulation and Evaluation of Microemulsion Based Luliconazole Gel for Topical Delivery 2020-03-12 10.5530/ijper.54.2.34 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-293.pdf Introduction: Drug delivery through topical route is mostly preferred for local dermatological action. Topical action of preparations has certain limitations in terms of drug solubility, residence time, lipophilicity and permeability. Conventional dosage forms such as creams, ointments etc exhibit drawbacks like problem in stability, stickiness, poor absorption as well as permeation mainly in case of large molecule. To overcome this, the origination of emulgel came into existence which basically Luliconazole, Linseed oil, Sodium alginate, Microemulsion, Topical, Antifungal, in vitro permeation https://www.ijper.org/article/54/2/337-348 2026-04-13T05:54:57.875565+00:00 Design and Development of Darunavir Loaded Self Micro Emulsifying Drug Delivery System using Extreme Vertices Mixture Design in a Quality by Design Framework 2020-03-12 10.5530/ijper.54.2.39 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-337.pdf Aim: The therapeutic utility of many poorly water-soluble drugs are severely restricted for their bioavailability. The present study was aimed to development of self-micro emulsifying drug delivery (SMEDDS) system for a poorly water soluble anti-retroviral drug - Darunavir by the application of Quality by Design (QbD) to increase its bioavailability. Methodology: Extreme Vertices Mixture Design (EVMD), based on its utility and the applicability to the formulation problem in hand was selected for Antiretroviral, Darunavir, Extreme vertices, Self-emulsified system, QbD https://www.ijper.org/article/54/2/422-431 2026-04-13T05:54:57.875565+00:00 Cerebral Cortex and Hippocampal Protection Mediated by Callistemon viminalis in Aluminium Chloride Induced Alzheimer’s Disease 2020-03-12 10.5530/ijper.54.2.48 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-422.pdf Aim: The study was carried out to evaluate the neuroprotective effect of methanol extract of Callistemon viminalis in aluminium chloride induced dementia of alzheimer’s type in mice. Methods: Swiss albino mice of either sex were divided into 5 groups: vehicle control; AlCl3 + normal saline; AlCl3 + rivastigmine; AlCl3+ extract (50 mg/kg; p.o); AlCl3 + extract (100 mg/kg; p.o). The following parameters were analyzed in all groups: a) Behavioral parameters- morris water maze test, b) Biochemical p Morris water maze, AchE, GSH, Catalase, SOD, Nitrite, Callistemon viminalis https://www.ijper.org/article/54/2/440-447 2026-04-13T05:54:57.875565+00:00 LC-MS/MS Determination and Pharmacokinetics Study of Apremilast after Oral Administration in Rabbits 2020-03-12 10.5530/ijper.54.2.50 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-440.pdf Objectives: A selective and reproducible method has been optimised for evaluation of Apremilast in rabbit biological matrices by UPLC-ESI-MS/MS. Methods: The analytical technique was implemented to quantify the apremilast in rabbit plasma samples with Apremilast-D5 as deuterated internal standard. The chromatographic separation tuned with 10mM Ammonium Acetate Buffer (pH: 4.0): Methanol: Acetonitrile, (20:40:40%, v/v/v) using the CORTECS C18, 2.7 μ.m, 4.6 m.m X 150 m.m analytical column with ana Apremilast, Rabbit plasma, UPLC-ESI-MS/MS, Bio-analysis, Pharmacokinetic, Therapeutic drug monitoring https://www.ijper.org/article/54/2/349-356 2026-04-13T05:54:57.875565+00:00 Cytotoxicity and Pharmacokinetic Studies of PLGA Based Capecitabine Loaded Nanoparticles 2020-03-12 10.5530/ijper.54.2.40 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-349.pdf Background: Colorectal cancer ranked fourth as devastating cancer globally based on statistical death analysis. The major challenge for treating colorectal cancer is to target the drug to the specific site of the colon. Purpose: The main objective of the present research was to develop PLGA based nanoparticles to target and sustain the drug release at the colon for effective treatment of colorectal cancer. The significance of using Eudragit S100 was to prevent drug release in the stomach and sma Capecitabine, Colorectal, Cancer, Cytotoxicity, MTT, PLGA https://www.ijper.org/article/54/2/367-375 2026-04-25T04:13:14.133903+00:00 Formulation and Evaluation by Appling 32 (Three Squire) Factorial Design of Lercanidipine Hydrochloride Buccal Tablets with Mucoadhesive Polymers 2020-03-12 10.5530/ijper.54.2.42 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-367.pdf Aim: The aim of the present research work is to develop buccal tablets of Lercanidipine hydrochloride to reduce dosage frequency; obtain optimized and controlled therapy, better patient compliance. Materials and Methods: Lercanidipine HCl was obtained as a gift sample from Sun Pharma, Baroda, India. Other ingredients like Na-alginate, Carbopol 934 P, Micro Crystalline Cellulose, Mannitol, Magnesium stearate, Ethyl cellulose and Hydroxy Propyl Methyl CelluloseK4M were purchased from various sourc Lercanidipine hydrochloride, Buccal tablets, HPMC K4M, Buccal permeation, study, Erosion controlled release https://www.ijper.org/article/54/2/448-455 2026-04-13T05:54:57.875565+00:00 Quantitative Analysis of Pantoprazole Sodium Sesquihydrate in Bulk and Solid Dosage Form via UV-Spectrophotometric Method 2020-03-12 10.5530/ijper.54.2.51 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-448.pdf Pantoprazole sodium sesquihydrate, is a proton pump inhibitor, was analyzed by using UV spectrophotometry. The quantification of pantoprazole sodium sesquihydrate in distilled water was performed in the wavelength range of 290 nm at 20 μgmL-1. The linearity range is 5-35 μgmL-1 by using UV spectrophotometry. The developed method was applied directly and easily to the analysis of the pantoprazole sodium sesquihydrate in bulk and pharmaceutical tablet preparations. The developed method was complet Pantoprazole sodium sesquihydrate, Proton pump inhibitor, UVSpectrophotometer, Method development, ICH guidelines https://www.ijper.org/article/54/2/465-470 2026-04-13T05:54:57.875565+00:00 HPLC Method for Determination of the Chemical Stability of Antimicrobial Peptide α-Defensin 2 2020-03-12 10.5530/ijper.54.2.53 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-465.pdf Aim: The aim of this research study was to develop a simple, rapid, precise, accurate and economical RP-HPLC method, with a simple mobile phase for the identification and determination of the antimicrobial peptide α-defensin-2. Materials and Methods: Separation was carried out at 25°C, using column Luna 5U (C18, 250x4.6, 5 μm) with mobile phase consisting of acetonitrile: water (40: 60 v/v). The detector was set at 210 nm. The flow rate was 1.2 ml/min and injection volume was 20 μl. Results: The Antimicrobial peptides, α-defensin 2, HPLC, Chemical stability, Analysis https://www.ijper.org/article/54/2/416-421 2026-04-13T05:54:57.875565+00:00 Apoptosis of HeLa Cells via Caspase-3 Expression Induced by Chitosan-Based Nanoparticles of Annona squamosa Leaf Extract: In vitro Study 2020-03-12 10.5530/ijper.54.2.47 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-416.pdf Background: Annona squamosa is reported has a significant cytotoxic activity in some cancer cells. Objectives: Thus, this study aim to investigate Annona squamosa leaf extract induced by chitosan nanoparticles (nano-ASLE) to enhance their biological activity as anticancer agent on HeLa cells. Methods: Nano-ASLE (50, 100, 200, 400 μg/mL in DMSO) given on HeLa cells to determined IC50 value by MTT assay. Then, it was devided into three groups as follow IC50, 2IC50, 4IC50 continued with analysis of Annona squamosa, Cytotoxicity, Apoptosis, Caspase-3, Nanoparticles https://www.ijper.org/article/54/2/403-415 2026-04-13T05:54:57.875565+00:00 Anti-urolithiatic Activities of Macrotyloma uniflorum Mediated through Multiple Pathway 2020-03-12 10.5530/ijper.54.2.46 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-403.pdf Background: Macrotyloma uniflorum Linn. (Fabaceae) seeds are widely used for their diuretic and urolithiatic effects in India. The present study investigated the effect of n-butanol fraction of M. uniflorum (nBFMU) on kidney stone using in vitro and in vivo method. Materials and Methods: Nucleation, crystal growth, crystal aggregation and crystal dissolution assays were performed for nBFMU. Two doses of nBFMU (400 and 800 mg/kg) were studied for their diuretic activity and sodium oxalate (NaOx) Diuresis, Kidney stone, Macrotyloma uniflorum, Sodium oxalate, Urolithiasis https://www.ijper.org/article/54/2/471-483 2026-04-25T04:30:10.08883+00:00 Synthesis, in-silico Designing, SAR and Microbiological Evaluation of Novel Amide Derivatives of 1-(4-Nitrophenyl)-2-(3-methylbenzo[b] thiophen-6-yl)-1H-benzo[d]imidazole-5-carboxylic Acid 2020-03-12 10.5530/ijper.54.2.54 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-471.pdf Background: Due to this increasing predicament of antibiotic confrontation, the lot of distinct antibiotics available is dwindling and there are only smatterings of new antibiotics in the drug development channel. Therefore, an intense necessitate for new antimicrobial drugs. In current study, we have synthesized the new derivatives with the help of molecular docking studies and investigated antimicrobial activities. Methods: By focusing the enzymes i.e. aminoacyl-tRNA synthetase (AaRS) and tyro Benzimidazole, 1jil.PDBQT, 1wny.PDBQT, Antimicrobial Activity, SAR https://www.ijper.org/article/54/2/397-402 2026-04-13T05:54:57.875565+00:00 Biochemical Investigation of the Protective Effect of Thiamine Pyrophosphate on Methotrexate-Induced Gastrotoxicity in Rats 2020-03-12 10.5530/ijper.54.2.45 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-397.pdf Aim: The aim of the study is to investigate the protective effect of thiamine pyrophosphate on methotrexate- induced gastrotoxicity biochemically in rats and to compare it with thiamine. Methods: Rats were divided into four groups as sham (SG), thiamine+ methotrexate (TAMTX), thiamine pyrophosphate+methotrexate (TPMTX) and Methotrexate (MTX) groups. 5 mg/kg methotrexate was administrated to 24 hrfasted rat groups by oral gastric tube except sham rats. 20 mg/kg thiamine was injected to TAMTX grou Gastrotoxicity, Methotrexate, Thiamine, Thiamin pyrophosphate, Ulcer https://www.ijper.org/article/54/2/484-490 2026-04-13T05:54:57.875565+00:00 Antioxidants with Multivitamin and Mineral Supplementation Attenuates Chemotherapy or Radiotherapy-induced Oxidative Stress in Cancer Patients 2020-03-12 10.5530/ijper.54.2.55 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-484.pdf Aim: The present study was planned to evaluate the combined effects of antioxidant multivitamin and minerals (AMM) in reducing cancer and cancer therapy-induced oxidative stress. In addition cell viability of human malignant melanoma and normal mouse fibroblast cell lines after treatment with different concentrations of AMM and methotrexate were also estimated. Methods: Amongst the 120 cancer patients recruited for the study, 60 patients each were treated with radiotherapy and chemotherapy. In b Cancer, Antioxidants, Multivitamin, Chemotherapy, Radiotherapy https://www.ijper.org/article/54/2/279-283 2026-04-13T05:54:57.875565+00:00 Innovation and Construction of Examination Database of Pharmacology 2020-03-12 10.5530/ijper.54.2.32 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-279.pdf Background: Pharmacology is one of the cornerstones in medical curricula, besides, examination is an effective way to evaluate the teaching quality and student outcome. Objectives: This study was undertaken to demonstrate the examination innovation and construction of online exam questions bank of Pharmacology. Methods: The pharmacological exercises compiled previously were attached with standarded parameters and used as main source of online exam questions bank, the multifaceted parameters of q Pharmacology, Exam questions bank database, Exam reform, Clinical, medicine, Nursing https://www.ijper.org/article/54/2/310-322 2026-04-25T04:07:42.65022+00:00 Intranasal Nalbuphine Formulation for Faster Management of Pain in Prehospital Scenario; Its Safety and Comparative Efficacy in Animal Models 2020-03-12 10.5530/ijper.54.2.36 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-310.pdf Aim: Nalbuphine (NLB) is an approved opioid analgesic for the management of severe pain in wounds, battlefield injuries and is recommended to subsidize labour pain during childbirth. The study aims to develop an intranasal opioid formulation for faster pain relief. Secondly to avoid patient inconvenience and make it available for buddy care. In case of war, accident or any natural calamities the feasibility of giving drugs from the parenteral route is not feasible as it requires high skilled med Nalbuphine, Nasal drop, Gamma scintigraphy, 99mTc-Pertechnetate, Subacute, toxicity https://www.ijper.org/article/54/2/225-233 2026-04-13T05:54:57.875565+00:00 Small Molecules Polypharmacology for the Treatment of Breast Cancer: A Roadmap for the Future Chemotherapy 2020-03-12 10.5530/ijper.54.2.27 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-225.pdf Background: Breast cancer is considered as the most common ailment in women across the globe. There are a variety of major factors for the growth and progression of breast cancer. Although genetic changes are key factors for cancer progression, epigenetic and environmental factors also have their fair share of contribution. Hypothesis: An attempt has been made in the review to highlight about small molecule polypharmacology for the treatment of breast cancer which is the design of small molecule Breast cancer, Small molecules, Polypharmacology, Tyrosine kinases, Chemotherapy https://www.ijper.org/article/54/2/329-336 2026-04-13T05:54:57.875565+00:00 QbD Based Optimization of Curcumin Nanoemulsion: DoE and Cytotoxicity Studies 2020-03-12 10.5530/ijper.54.2.38 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-329.pdf Aim: The aim of this study was to employ a Quality by design (QbD) based approach for the development and optimization of stable curcumin (CUR) nanoemulsion (NE). Materials and Methods: The NE was developed using Tween 80 as surfactant, Tocopheryl polyethylene glycol 1000 succinate (TPGS) as cosurfactant and Kollisolv MCT 70 as oil phase. The Design of Experiment (DoE) consisted of a 3 level- 2 factor full factorial design for the optimization. The independent variables were concentration of sur Nanoemulsion, QbD, Curcumin, Full factorial design, DoE https://www.ijper.org/article/54/2/234-250 2026-04-20T11:30:10.723678+00:00 Drug-induced Hepatotoxicity and Hepatoprotective Medicinal Plants: A Review 2020-03-12 10.5530/ijper.54.2.28 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-234.pdf The Liver, a paramount organ is the Chief site for metabolism of nutrients and energy production in the human body. It is also necessary for metabolism and elimination of exogenous drugs and harmful substances via kidney. Hepatotoxicity caused by a variety of environmental pollutants, pathogenic micro-organism, viruses, drugs and chemical agents may account for various hepatic diseases such as jaundice, necrosis, hepatitis, fibrosis and cirrhosis etc. Ayurveda is a traditional medicinal system o Medicinal Plants, Carbon tetrachloride, Paracetamol, Alcohol, Hepatotoxicity, Hepatoprotection https://www.ijper.org/article/54/2/302-309 2026-04-13T05:54:57.875565+00:00 Formulation and Evaluation of Carbamazepine Tablets using Biosurfactant in Ternary Solid Dispersion System 2020-03-12 10.5530/ijper.54.2.35 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-302.pdf Objectives: The present study is aimed to develop and evaluate Carbamazepine tablets using ternary solid dispersed product. Carbamazepine belongs to BCS class II having low solubility. Ternary system was formulated with biosurfactant and water-soluble polymers to enhance dissolution rate and bioavailability. Methods: Binary and ternary solid dispersion was prepared using hydroxyl propyl methyl cellulose (HPMC) K-100, Polyvinyl pyrolidine (PVP) K-30 and Poly ethylene glycol (PEG) 6000 as a polyme Carbamazepine, Solid dispersion, Ternary system, Biosurfactant, in-vivo oral, toxicity https://www.ijper.org/article/54/2/264-270 2026-04-20T11:31:23.955762+00:00 Indian Journal of Pharmaceutical Education and Research: A Scientometric Analysis 2020-03-12 10.5530/ijper.54.2.30 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-264.pdf Aim: Scientometric profile of Indian Journal of Pharmaceutical Research has been carried out in this study to highlight and identify the year-wise growth of publication and citation, authorship pattern, prolific organizations, countries, citation profile, international outreach, two year and five year impact factor trend during year 2007-2018. Materials and Methods: Web of science core collection database of Clarivate Analytics was used to retrieve the data using advance search feature. Search f IJPER, Citation profile, Scientometrics, Pharmaceutics, Journal evaluation https://www.ijper.org/article/54/2/251-263 2026-04-13T05:54:57.875565+00:00 Epidermodysplasia Verruciformis: Functional Role of E6 and E7 Oncoproteins as the Link between Viral Infection to Carcinogenesis 2020-03-12 10.5530/ijper.54.2.29 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-251.pdf Background: Cancer is the most dreadful disease since last few decades. Besides all causative reasons, it is observed that one in every five cancers globally is linked with infectious diseases. Among all the infectious oncogenic viruses, 35% of the human cancers have been caused by Human Papilloma Viruses (HPVs). One such type is Epidermodysplasia Verruciformis (EV), a tropical disease also known as the Tree man syndrome. Hypothesis: EV is one of the most potential illustrations linking viral in Epidermodysplasia Verruciformis, HPV, Skin Carcinogenesis, EVER genes, E6 and E7 oncoproteins https://www.ijper.org/article/54/2/357-366 2026-04-25T04:12:18.78515+00:00 Cyclosporine A Loaded Nanoemulsions using Bio-oil Fractions of Sesame Oil 2020-03-12 10.5530/ijper.54.2.41 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-357.pdf Title: Cyclosporine A loaded Nanoemulsions using Bio-oil Fractions of Sesame Oil. Aim: Nanoemulsions formulation development is an upcoming approach to deliver peptides. The approach reduces challenges during peptide delivery by many folds. Nanoemulsions contains drugs encapsulated or solubilized in an oily phase, with water as continuous phase. In our research, nanoemulsion have been developed for Cyclosporine a using fractions of Sesame oil as encapsulating agent. Methods: The comparison betwe Cyclosporine A, Nanoemulsions, Sesame oil, Biolipid, GCMS, IR https://www.ijper.org/article/54/2/271-278 2026-04-13T05:54:57.875565+00:00 Students’ Perceptions about Social Constructivist Learning Environment in e-learning 2020-03-12 10.5530/ijper.54.2.31 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-271.pdf Aim/Background: Pharmacy educators often incorporate electronic learning or e-learning to facilitate learning among pharmacy students. E-learning can be designed based on the Social Constructivism Theory (SCT). The learning outcomes of e-learning that is developed based on the SCT should be assessed continuously and they should include the evaluation of students’ perceptions on the Social Constructivist Learning Environment (SCLE) of their e-learning. The present study aims to investigate pharma Constructivist Online Learning Environment Survey, e-learning, Pathology, Pharmaceutical Care, Social Constructivist Learning Environment https://www.ijper.org/article/54/2/323-328 2026-04-13T05:54:57.875565+00:00 Pro-Argin Technology Based Formulation of Eugenol Containing Toothpaste 2020-03-12 10.5530/ijper.54.2.37 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-323.pdf Introduction: Formation of cavities and hyper sensitivity are few dental problems, manifested by dental pain. Since long back, volatile oil present in clove buds (Myrtaceae) have been used as dental analgesic. Various toothpastes containing clove oil are marketed. Eugenol is chemically, terpenoids, active principle present in clove oil. It has several pharmacological potentials. Pro-argin technology is novel approach for formulation of toothpaste with arginine (8%) and calcium carbonate. Aim: Th Clove oil, Eugenol, Pro-argin technology, Toothpaste, Texture analysis https://www.ijper.org/article/54/2/223-224 2026-04-20T11:29:00.848108+00:00 Curiosity-Driven Science and Indian Academia 2020-03-12 10.5530/ijper.54.2.26 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-223.pdf In recent years, Institutions and Universities are ranked both nationally and internationally based on multiple criteria, academics, research outputs, infrastructure, student enrolments etc. Unfortunately, none of the Indian Universities are ranked globally in the first 200-250 Universities. There is only one institution of worth mentioning, the Bengaluru-based Indian Institute of Science (IISc). It figures in the brackets of 250 to 350. The other institutes which make the list in the bracket up Editorial https://www.ijper.org/article/54/2/284-292 2026-04-20T11:32:57.509204+00:00 Optimization of in-situ Nanoparticulate Gel of Ofloxacin using Factorial Design to Improve Treatment Strategy for Conjunctivitis and Corneal Ulcers 2020-03-12 10.5530/ijper.54.2.33 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-54-2-284.pdf Background: One of the main problems in ophthalmic drug delivery is the rapid elimination of conventional liquid eye drops from the eye due to rapid tear turnover resulting precorneal loss because of irritation caused by the drug preparation from large volume of the administered eye drop (~50 μl), a very small amount i.e. <5% of the dosage actually penetrates and is able to reach intraocular tissues. Ofloxacin (OFL), a fluoroquinolone drug is used for the treatment of conjunctivitis and corneal Ofloxacin, Nanoparticle(s), Nanoparticulate in-situ gel, Conjunctivitis, Factorial design https://www.ijper.org/article/53/4s/s619-s623 2026-04-20T10:42:50.952253+00:00 Development of Non-invasive Electroencephalography Technique in Animal Model 2019-11-18 10.5530/ijper.53.4s.157 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-619.pdf Aim: This paper describes about the new non-invasive method to measure brain waves from the scalp of the rats. The method allows to record good quality Electroencephalogram (EEG) from freely moving rats in the cage. Methods: This experiment targeting rodents used simple adhesive patch containing conductive gel placed on the scalp of the rats has a potential to measure the brain waves without any surgical intervention. Stable electrode gel shown to have good conductivity and strongly bonds to the Electroencephalogram, Fast Fourier Transform, Stereotaxis equipment, Frequency bands, Conductive gel, Absolute Power https://www.ijper.org/article/53/4s/s510-s517 2026-04-13T05:55:01.441434+00:00 Genotoxicity of Monosodium Glutamate: A Review on its Causes, Consequences and Prevention 2019-11-18 10.5530/ijper.53.4s.145 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-510.pdf Monosodium Glutamate (MSG) is a common food additive used in processed foods to enhance the taste. The data available on Google scholar, NCBI, PUBMED, EMBASE, Wang fang databases, meta-analysis and Web of Science were reviewed to collect the information on the MSG-induced genetic damages, consequences and its mechanism. The retrieved information indicated that long-term consumption of MSG is associated with metabolic diseases, neurological and reproductive organ defects. Studies also suggested t Monosodium glutamate, Food additive, Genotoxicity, Oxidative stress, Antimutagens https://www.ijper.org/article/53/4s/s522-s538 2026-04-20T10:35:06.008304+00:00 Insight into Concept and Progress on Pharmaceutical Co-Crystals: An Overview 2019-11-18 10.5530/ijper.53.4s.147 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-522.pdf Pharmaceutical co-crystals have conferred significant recognition in recent past as a new solid form by virtue their capability to modulate physicochemical properties of Active Pharmaceutical Ingredient (API). Nevertheless, pharmaceutical progress of cocrystals could be provocation, the requirement for high-throughput screening methods and the techniques capable of co-crystal production in industrial scale still hamper the co-crystal used by industries. In this review, well ordered overview of p Co-crystals, Crystal engineering, Physicochemical properties, Co-crystallization, Translational challenges https://www.ijper.org/article/53/4s/s571-s579 2026-04-13T05:55:01.441434+00:00 Formulation, Development and Evaluation of Etoricoxib Nanosize Microemulsion Based Gel for Topical Drug Delivery 2019-11-18 10.5530/ijper.53.4s.152 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-571.pdf Introduction: Etoricoxib is a poorly water-soluble oral NSAID and is associated with a number of complications such as bleeding, ulcers and dyspepsia but these can be overcome by delivering the drug topically. Objectives: Microemulgel for the topical delivery of etoricoxib was formulated to increase its solubility and thus improve the skin permeability. Methods: The solubility of etoricoxib was studied in various oils, surfactants and cosurfactants. Pseudo-ternary phase diagrams were constructed Etoricoxib, Microemulsion, Topical gel, in vitro release, Particle size, Skin, irritation https://www.ijper.org/article/53/4s/s500-s509 2026-04-13T05:55:01.441434+00:00 Propolis Research in Russia 2019-11-18 10.5530/ijper.53.4s.144 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-500.pdf This review presents data on the current propolis research in Russia. The chemical composition, color, aroma and appearance of propolis are influenced by natural and climatic factors, the collection region and the originality of the flora in the collection place. Within Russia, organoleptic, physicochemical and chemical properties of propolis vary considerably. The article provides information on methods for assessing its quality. Propolis is widely used in folk and alternative branches of medic Antibacterial, Antioxidant, Diabetes, Flavonoids, Gastric ulcer, Propolis https://www.ijper.org/article/53/4s/s642-s649 2026-04-13T05:55:01.441434+00:00 Development and Validation of Genotoxic Impurity in Esomeprazole Magnesium Trihydrate Active Pharmaceutical Ingredient by LC-MS/MS 2019-11-18 10.5530/ijper.53.4s.160 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-642.pdf Objectives: A rapid, sensitive and selective analytical method has been developed and validated by liquid chromatography tandem Mass spectrometry (LC-MS/MS) for the quantification of traces of Cumene Hydroperoxide in Esomeprazole magnesium trihydrate active pharmaceutical ingredient. Materials and Methods: The chromatographic separation was carried out on a Develosil Phenyl phase-UG-5 150 x 4.6mm, 3μm column. The mobile phase consisting of 1% Ammonia solution buffer and acetonitrile, the flow ra LC-MS/MS, Esomeprazole magnesium trihydrate, Cumene Hydroperoxide, Method validation, ICH guidelines https://www.ijper.org/article/53/4s/s650-s654 2026-04-13T05:55:01.441434+00:00 Potential Effect of Steroidal Alkaloids from Sarcococca saligna against Leishmania tropica 2019-11-18 10.5530/ijper.53.4s.161 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-650.pdf Background and Objectives: Sarcococca species have a rich source of steroidal alkaloids that possess different biological and pharmacological activities. Hence, present research was design to isolate the steroidal alkaloid from Sarcococca saligna and to evaluate it for in-vitro antileishmanial activity. Materials and Methods: Compound Holaphylline and Saracodine were isolated through column chromatography followed by spectroscopic techniques for elucidation and were assayed against promastigotes Sarcococca saligna, Holaphylline, Saracodine, Leishmania tropica, Promastigotes, Chloroform extract https://www.ijper.org/article/53/4s/s596-s606 2026-04-13T05:55:01.441434+00:00 Formulation and Evaluation of Tamoxifen Citrate Loaded Transdermal Reservoir Gel Drug Delivery Systems 2019-11-18 10.5530/ijper.53.4s.155 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-596.pdf Background: Successful treatment of cancer is yet remained as a challenging concern in public health. Transdermal delivery of hormonal therapy offers several advantages over the oral route associated with potential side effects. Methods: The present investigation preparation and screening of rate controlling membranes using Eudragit release liners of RS 100, hydroxyl propyl methyl cellulose K4M (HPMC K4M) and ethyl cellulose by plate casting method and their physicochemical characterization. The Transdermal reservoir, Gel, Tamoxifen Citrate (TC), Penetration Enhancer https://www.ijper.org/article/53/4s/s563-s570 2026-04-20T10:37:21.996678+00:00 Design and Preparation of Zaltoprofen-Nicotinamide Pharmaceutical Cocrystals via Liquid Assisted Grinding Method 2019-11-18 10.5530/ijper.53.4s.151 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-563.pdf Introduction: Pharmaceutical cocrystal is an endowed approach to augment solubility and dissolution of drugs with limited aqueous solubility. Zaltoprofen is a nonsteroidal anti-inflammatory drug with prevailing solubility problem. The present study deciphers preparation of cocrystals of lipophilic drug zaltoprofen to improve the solubility and dissolution by screening various coformers. Methods: Cocrystals of zaltoprofen were prepared in 1:1 and 1:2 molar ratio of drug: coformer by liquid assist Cocrystal, Zaltoprofen, Liquid assisted grinding, Solubility, Dissolution https://www.ijper.org/article/53/4s/s539-s547 2026-04-13T05:55:01.441434+00:00 Design, Development and Evaluation of Self Nanoemulsifying Drug Delivery System of Garlic Oil using Capryol PGMC 2019-11-18 10.5530/ijper.53.4s.148 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-539.pdf Introduction: At present days there was considerable attention has been taken to develop lipid based pharmaceutical preparation which improves solubility as well as permeability leads to improve oral bioavailability of poorly water soluble drug with a system known as self nano-emulsifying drug delivery system. Materials and Methods: The SNEDDS of garlic oil was prepared by using oleic acid as oil, capryol PGMC as a surfactant and ethanol as a co-surfactant, as the garlic oil shows better solubil Self Nanoemulsifying Drug Delivery System, Garlic oil, Pseudo ternary phase, diagram, Capryol PGMC, poorly water soluble drug https://www.ijper.org/article/53/4s/s710-s720 2026-04-20T10:55:31.336818+00:00 Pharmacognostical and Proximal Analysis of Two different Extracts (Methanol and Aqueous) of Indian Endangered Coscinium fenestratum Stem 2019-11-18 10.5530/ijper.53.4s.168 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-710.pdf Background: Coscinium fenestratum (CF) (Family: Menispermaceae), an endangered and highly commercial medicinal plant of traditional system of medicine. Stem is commercially important which have multiple medicinal used and therapeutic efficacy. The objective of the study is to evaluate the effect of extraction, content of elements and their correlation on proximate analysis and detection of compound in various extracts of Indian endangered Coscinium fenestratum stem. Materials and Methods: Proxim Coscinium fenestratum, Proximate, Elemental analysis, Microscopic, character, SEM https://www.ijper.org/article/53/4s/s481-s486 2026-04-13T05:55:01.441434+00:00 Therapeutic Proteins through Phage Display- A Brilliant Technique for its Simplicity 2019-11-18 10.5530/ijper.53.4s.142 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-481.pdf Background: Phage Display Technology is an advanced version of rDNA and hybridoma technologies with simplicity in its procedure and production of desired therapeutics and biocontrol products. In this context, the filamentous bacteriophage namely M13 phage was explored by the Nobel Laureates, George P Smith and Gregory P Winter. Due to the unique tolerance of M13 phage to experimental conditions compared to the tailored B-cells, the global bacteriophage mediated pharma market is at its up-surge. Phage Display, M13, George P Smith, Sir Gregory P Winter, Pharma Market https://www.ijper.org/article/53/4s/s691-s698 2026-04-13T05:55:01.441434+00:00 Stability-Indicating RP-HPLC Method for the Quantification of Paliperidone in Bulk and Solid Dosage Form to Establish Validation and Stability Indicating Parameters 2019-11-18 10.5530/ijper.53.4s.166 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-691.pdf Objectives: In the present research work, stability indicating reverse phase high performance liquid chromatography method was developed and validated for the quantification of paliperidone in bulk and solid dosage form. Materials and Methods: The chromatographic separation of paliperidone was carried out using Phenomenex, Gemini NX, Octadecyl silane column (150x4.6 mm, 5 µm, particle size) with the mobile phase consisting of methanol: acetonitrile: 0.15% v/v triethylamine in water (pH 6) in the Paliperidone, RP-HPLC, Stability of analytical solution, Validation, Stress, testing https://www.ijper.org/article/53/4s/s699-s709 2026-04-20T10:54:42.473034+00:00 Analytical Quality by Design Assisted HPLC Method for Quantification of Canagliflozin/ Metformin and Stability Studies 2019-11-18 10.5530/ijper.53.4s.167 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-699.pdf Aim: Current work entails the analytical quality by design (AQbD) based robust HPLC method for real-time analysis of canagliflozin and metformin. Different pKa values of two drugs made their chromatographic separation critical. Materials and Methods: The critical method parameters were systematically optimized using factorial experimental design (central composite design) and contours were generated as a function of significant variables when analyzed in the modeling software. The method operabl AQbD, HPLC, Canagliflozin, Metformin, Degradation https://www.ijper.org/article/53/4s/s607-s618 2026-04-13T05:55:01.441434+00:00 Screening and Identification of Plant Metabolites against Snake Venom Enzymes using in vitro to in silico Approach 2019-11-18 10.5530/ijper.53.4s.156 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-607.pdf Aim/Background: Snakebites are generally a neglected tropical disease that have harmful impact on thousands of people globally. Although antiserum therapy is the only management available for snakebites, several side effects of this therapy have raised the requirement of an alternative to treat snakebite or boost antiserum efficacy. The present study aimed to provide a scientific explanation for the use of plants extracts in neutralizing snake venom enzymes phospholipase A2, hyaluronidase, DNase Phospholipase A2, Hyaluronidase, Deoxyribonuclease, Ribonuclease, Dryopteris cochleata https://www.ijper.org/article/53/4s/s451-s459 2026-04-13T05:55:01.441434+00:00 New Drugs and Clinical Trials Rules, 2019: Towards Fast-track Accessibility of New Drugs to the Indian Population 2019-11-18 10.5530/ijper.53.4s.138 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-451.pdf Background: To fulfil the objective of fast-tracking the accessibility of new drugs and promoting clinical research in India, the Union Ministry of Health and Family Welfare, India has notified the “New Drugs and Clinical trials Rules, 2019” on 25th March 2019. The prime objective of the new rule is to initiate unambiguous, foreseeable and effective regulations for the clinical trials in India. Drugs Controller General of India (DCGI) affirmed that the new rules would apply to all new drugs, inv Clinical trials, New Drugs and Clinical trials Rules 2019, DCGI, India https://www.ijper.org/article/53/4s/s655-s665 2026-04-13T05:55:01.441434+00:00 Novel Chroman Analogs as Promising Heterocyclic Compounds: Their Synthesis and Antiepileptic Activity 2019-11-18 10.5530/ijper.53.4s.162 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-655.pdf Aim: New series of novel chroman analogs was designed and synthesized using appropriate synthetic route. Materials and Methods: Structures of synthesized chroman hydrazides fused with different anhydrides were supported by spectral data. After the neurotoxicity, assessed by rotarod motor impairment method, antiepileptic activities of twenty synthesized compounds were evaluated by both Pentylenetetrazole Seizure (PTZ) and Maximal electroshock seizure (MES) methods on mice. Administration at the s Anhydride, Antiepileptic, Chroman, Neurotoxicity, Synthesis https://www.ijper.org/article/53/4s/s684-s690 2026-04-13T05:55:01.441434+00:00 Analgesic and Anti-allodynic Effects of Two Flavonoids in Partial Sciatic Nerve Ligation in Rat Model 2019-11-18 10.5530/ijper.53.4s.165 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-684.pdf Background: Flavonoids, also called as bioflavonoids, are secondary metabolites of plants. Flavonoids, curcumin and hesperidin, possess various pharmacological activities such as analgesic, anti-ulcer, anti-parkinson, anti-cancer, spasmolytic, anti-bacterial, anti-depressant, anti-hypertensive, anti-arthritic and anti-inflammatory. Aim: The current study investigated the analgesic and anti-allodynic effects of flavonoids (curcumin and hesperidin) and compared their effects with pregabalin agains Flavonoids, Neuropathic pain, Analgesic, Anti-allodynic, Curcumin, Hesperidin, Partial Sciatic Nerve Ligation (PSNL), Hyperalgesic https://www.ijper.org/article/53/4s/s678-s683 2026-04-20T10:53:18.263179+00:00 Cassia auriculata L.: An Ethno Medical Approach in Exploring Anti-solar Efficacy 2019-11-18 10.5530/ijper.53.4s.164 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-678.pdf Objectives: The present study deals with an in-vitro screening for the anti-solar potential of aqueous and ethanolic extracts of Cassia auriculata using the UV method. Methods: Aqueous and ethanolic extracts were prepared. Thus, prepared extracts were subjected to phytochemical investigation and evaluated for antioxidant effect using DPPH and antisolar efficacy. Concentrations ranging from 7.8 to 1000 μg/mL (serial dilution) were used for the determination of radical scavenging effect and concen Anti-solar, Carcinogenic, Cassia auriculata Linn, DPPH, SPF, UV https://www.ijper.org/article/53/4s/s630-s641 2026-04-13T05:55:01.441434+00:00 Stress Degradation Studies of Riociguat, Development of Validated Stability Indicating Method, Identification, Isolation and Characterization of Degradation Products by LC-HR-MS/MS and NMR Studies 2019-11-18 10.5530/ijper.53.4s.159 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-630.pdf Aim: The present study reports the degradation behavior of new antihypertensive drug Riociguat under various stress conditions as per International Conference on Harmonization guidelines ICH, Q2(R1). Materials and Methods: Riociguat was subjected to stress degradation under hydrolytic (acidic, alkaline and neutral), oxidative, photolytic and thermal stress conditions to investigate the inherent stability. A rapid, accurate, precise and robust HPLC method was developed on Waters Symmetry C18 Colu Riociguat, Stress degradation, RP-HPLC, LC-HR-MS/MS, Preparative HPLC, NMR https://www.ijper.org/article/53/4s/s624-s629 2026-04-13T05:55:01.441434+00:00 One Step Towards: The Synthesis of Optimized Coumarin Derivatives as an Anti-HIV Agent 2019-11-18 10.5530/ijper.53.4s.158 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-624.pdf The development for the sustainable approach was a key ingredient for the research, especially in the field of drug development against HIV. Several attempts have been made in the positive direction for the treatment of fatal disease, however the suitable lead was missing in the therapeutically arena. Many different kinds of natural products, including coumarins, have been found to be active in the various anti-HIV models and still investigation is undergoing. The present finding demonstrates th Coumarins, HIV integrase inhibitors, Protease inhibitors, Reverse transcriptase, inhibitors, QSAR https://www.ijper.org/article/53/4s/s466-s474 2026-04-13T05:55:01.441434+00:00 A Review on Complications Confronted with Skin Penetration and Assessment of Topical Formulations in Dermal Drug Development 2019-11-18 10.5530/ijper.53.4s.140 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-466.pdf A topical drug-delivery system is the most accepted drug delivery system. One of the pre-requisites for a topical formulation is its ability to penetrate the skin membrane to elicit the intended action. Many in vitro skin permeation studies are reported by scientists to evaluate the penetration of the drug into human skin. Several direct methods including tape stripping, in vitro percutaneous studies measures skin tissue concentration. While indirect methods like plasma collection, micro-dialysi Skin permeation, Microdialyis, in vitro Percutaneous Studies, Tape stripping, Skin contamination https://www.ijper.org/article/53/4s/s666-s677 2026-04-20T10:50:42.417618+00:00 Complimentary Effects of Curcumin for Enhancing Efficacy of Acetylsalicylic Acid against Prostate Cancer 2019-11-18 10.5530/ijper.53.4s.163 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-666.pdf Background: Prostate cancer is the 6th leading cause of cancer death worldwide. Androgen Deprivation Therapy (ADT) in prostate cancer enhances the risk of Rheumatoid Arthritis (RA). Acetylsalicylic Acid (ASA) can be potentially repurposed against prostate cancer and arthritis. However, its efficacy is low and use is associated with nephrotoxicity as well as gastrotoxicity. Curcumin with reported ability to potentiate anti-inflammatory effects and reduce oxidative stress, can be used as a complem Acetylsalicylic acid, Androgen deprivation, Prostate cancer, Arthritis index, Gastric ulcer https://www.ijper.org/article/53/4s/s587-s595 2026-04-13T05:55:01.441434+00:00 Development and Bioavailability Assessment of Ramipril Nanoparticle Formulation 2019-11-18 10.5530/ijper.53.4s.154 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-587.pdf Ramipril, potent anti-hypertensive agent has been used in the treatment of hypertensive disorders. It has low bioavailability of 28-35% and short biological half-life (i.e. 2-4 hr). Thus this study attempts to evaluate chitosan-alginate nanoparticles as a novel drug delivery for Ramipril to sustain drug release and improve oral bioavailability. Nanoparticles were prepared by ionotropic pre-gelation technique using chitosan and sodium alginate polymers. Total nine formulations (F1 to F9) were pre Ramipril, Chitosan, Sodium alginate, Ionotropic pre-gelation technique, Chitosan-alginate polymeric complex, pH sensitive, Oral bioavailability https://www.ijper.org/article/53/4s/s475-s480 2026-04-13T05:55:01.441434+00:00 Recent Advancements in Spectrophotometric pKa Determinations: A Review 2019-11-18 10.5530/ijper.53.4s.141 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-475.pdf The pKa value is a key feature in Absorption, Distribution, Metabolism and Excretion (ADME) of drugs, thus knowing this value is critical in drug development. In this review, pKa values determined in the past decade, using UV-Vis spectrometry, are discussed. To determine the pKa, four methods were applied; Henderson-Hasselbach, Albert-Serjeant, Bates-Schwarzenbach and Spectrometric titrations. This review will show the value of this aged but well-established technique in the past decade, due to Albert-Serjeant, Bates-Schwarzenbach, Henderson-Hasselbach, pKa, Spectroscopy, Titrations https://www.ijper.org/article/53/4s/s554-s562 2026-04-20T10:37:01.062041+00:00 Solvent-free Hot Melt Extrusion Technique in Improving Mesalamine Release for Better Management of Inflammatory Bowel Disease 2019-11-18 10.5530/ijper.53.4s.150 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-554.pdf Background: Poor oral bioavailability of mesalamine (Mes) is due to extensive metabolism in the intestinal epithelial cells in addition to the liver. Purpose: Improved mesalamine release by Hot-Melt Extrusion (HME) technique could be utilized for better management of Inflammatory Bowel Disease (IBD). Methods: Mes and hydrophilic polymers like Eudragit- EPO, KollidonVA-64 and PEG 6000 were hot-melt extruded using a co-rotating twin-screw laboratory extruder. Results: The minor shifting with signi Hot-melt extrusion, Solvent-free drug loading, Mesalamine, Feret diameter, Improving Release https://www.ijper.org/article/53/4s/s487-s499 2026-04-20T10:32:59.713827+00:00 Difficulties Facing the Patients and Extra Burden for Healthcare Providers by Non-adherence to the Medications - A Comprehensive Review 2019-11-18 10.5530/ijper.53.4s.143 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-487.pdf Background: Compliance is commonly and always being confused with concordance, which is a process by which a patient and health care provider make discussion and decisions together about treatment and their outcomes. General worldwide, noncompliance is a major obstacle and main challenges to the effective and efficient health care delivery. Estimation in 2003 by the World Health Organization indicates that only approximately 50% of chronic diseases patients that us living in developed countries Non-adherence, Quality in health care, Patient burden, Drug Compliance, Comprehensive https://www.ijper.org/article/53/4s/s518-s521 2026-04-13T05:55:01.441434+00:00 Genotype-8: A Modern Family Member of Hepatitis C Virus 2019-11-18 10.5530/ijper.53.4s.146 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-518.pdf Hepatitis C Virus (HCV) is a highly diverse and pervasive disease around the globe, with a prevalence ranging from 1.5 to 2.3%. With wide genetic variability, it is classified into seven Genotypes (GT) with 67 subtypes. The sighting of a modern HCV GT-8 ratifies its endemic character in India, particularly in the Punjab State. Getting familiarized and making aware of the HCV genotypes and subtypes is necessarily essential in establishing the optimal treatment regimen. Hepatitis C, RNA virus, Epidemiology, Genotype Classification, Genotype 8, India https://www.ijper.org/article/53/4s/s460-s465 2026-04-20T10:30:25.709042+00:00 Improved Method for Differentiation of Synthetic and Natural Endogenous Anabolic Steroids using Gas Chromatography Isotope Ratio Mass Spectrometry (GC/C/IRMS) followed by Two-Fold High Performance Liquid Chromatography (HPLC) Cleanup Method: A Perspective 2019-11-18 10.5530/ijper.53.4s.139 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-460.pdf Background: Androgenic Anabolic Steroids (AAS) are also synthetic derivatives of testosterone, modified to improve its anabolic actions. The misuse of AAS is of particular concern in sports and society. Gas chromatography-mass spectrometry had some limitations and allows identification and characterization of steroids and their metabolites in the urine but may not be able to distinguish between pharmaceutical (Exogenous) and endogenous origin. Thus, it is of great importance to discriminate endo Endogenous Steroids, Exogenous Steroids, HPLC Cleanup, Doping, GC/C/, IRMS https://www.ijper.org/article/53/4s/s580-s586 2026-04-13T05:55:01.441434+00:00 Sustained Release Bioadhesive Suppository Formulation for Systemic Delivery of Ornidazole: In-silico Docking Study 2019-11-18 10.5530/ijper.53.4s.153 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-580.pdf Background and Objectives: Ornidazole is widely used as an antiprotozoal and antiamoebic drug and its onset of action is within 2 h. The major extent of the drug is metabolized in the liver and excreted in the urine and faeces. Hence, the present study of suppository formulation for sustained systemic delivery of ornidazole is significant which could minimize abdominal disturbances and nausea and delayed onset of action particularly after oral administration. Methods: Bioadhesive suppository for Ornidazole, Sustained release suppository, In-silico docking, Bioadhesive, formulation, in-vitro dissolution https://www.ijper.org/article/53/4s/s548-s553 2026-04-13T05:55:01.441434+00:00 Formulation and Development of Famotidine Solid Dispersion Tablets for their Solubility Enhancement 2019-11-18 10.5530/ijper.53.4s.149 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4s-548.pdf Background: Famotidine is BCS class II drug having a low aqueous solubility and low oral bioavailability. It needs to develop into its novel form for solubility and dissolution rate enhancement. Materials and Methods: The aim of the current work was to formulate famotidine (FAM)-poloxamer 188 solid dispersions (SDs) by kneading method for solubility enhancement. The problems of low solubility were eliminated by preparing the SDs using the poloxamer 188 as hydrophilic carrier. Results and Conclus Solid dispersions (SDs), Kneading method, Famotidine, Solubility, Dissolution, rate, Bioavailability https://www.ijper.org/article/53/4/724-732 2026-04-13T05:55:02.455561+00:00 Formulation Development and Evaluation of Gastro Retentive Bio Adhesive Drug Delivery System for Moxifloxacin. HCl 2019-09-18 10.5530/ijper.53.4.137 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4-724.pdf Objective: The purpose of present research work is to develop gastro retentive formulation for Moxifloxacin using various drug release modifiers. Moxifloxacin, novel synthetic fluoro quinolone, antibacterial agent. Methods: SR granules were prepared by gastro retentive tablets of Moxifloxacin. HCl were prepared using variable amounts of HPMCK100M, Lannea coromandelica gum (LCG) by moist granulation technique. Totally 10 SR granule formulations were prepared and subjected to precompression analys Moxifloxacin. HCl, Gastroretentive, Bio adhesion, HPMCK100M, Lannea, coromandelica gum, Swelling Study https://www.ijper.org/article/53/4/716-723 2026-04-20T10:22:26.690599+00:00 Characterization of Thermal Fraction of Clarified Butter and its Applicability to Improve Bioavailability of Rosuvastatin 2019-09-18 10.5530/ijper.53.4.136 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4-716.pdf Aim: The present investigation shows confirmatory evidence for the complex formation of Rosuvastatin with a fraction of Clarified Butter. Materials and Methods: Fractions of Clarified Butter prepared according to thermal behavior at different temperatures (30°C, 40°C, 50°C). Rosuvastatin biform complex with Clarified Butter in the ratio (1:1) and (1:2) w/w were prepared. Physicochemical properties of all fractions of Clarified Butter was determined as per Indian Pharmacopoeia. The fractions were Rosuvastatin, Clarified Butter, Peroxide value, Thermal oxidation, Bioavailability https://www.ijper.org/article/53/4/577-594 2026-04-20T10:12:49.494832+00:00 Skin Targeting Approaches in Cosmetics 2019-09-18 10.5530/ijper.53.4.119 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4-577.pdf Objective: To emphasize and summarize the main component of skin and approaches to target them. Methods: Skin targeting approaches in cosmetics is a review of all the relevant papers known to the author was conducted. Results: The exhaustive review on the basis of the previously reported paper revealed that the skin is a complicated and intact structure having vast of targeting component such as Keratin, Elastin fibres, ECM, MMPs, collagen, Hyaluronic Acid etc and apart from that the receptor an Skin, Targeting, ECM, MMPs, Collagen, EGFr, IL-1r, TNFr, PDGFr, PAF-r, Nanocarriers https://www.ijper.org/article/53/4/629-637 2026-04-13T05:55:02.455561+00:00 Comparative Study Between China 2018 National Accreditation Standard for Teaching Quality of Clinical Pharmacy and ACPE 2015 Accreditation Standards and Guidelines 2019-09-18 10.5530/ijper.53.4.124 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4-629.pdf Background: Rapid development of the China economy has gradually increase the demand of the medical resources. To please this increasing demand for enhanced medical services, National Health Commission of the People’s Republic of China has set an “Interim Provisions Administration of Pharmaceutical Affairs in Medical Institutions” in 2002 stated that “the clinical pharmacist should take part in the diagnosis and treatment of disease, provide pharmaceutical care and improve the quality of medical Clinical pharmacy, MOE, ACPE, Standards and guidelines, China 2018, national accreditation and standards https://www.ijper.org/article/53/4/595-602 2026-04-13T05:55:02.455561+00:00 Evaluation of Computer-based Simulation Learning on Knowledge, Learning Approaches and Motivation among Pharmacy Students 2019-09-18 10.5530/ijper.53.4.120 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4-595.pdf Background: With the exponential influence of technology on students’ learning, Computer-based Simulation Learning (CSL) has perceived to have great potential in enhancing the training of healthcare professionals including pharmacists. However, limited evidence is available to compare its impacts on knowledge gained and learning approaches to that of conventional lectures. Materials and Methods: A total of 168 pharmacy students were randomly assigned to “CSL group” (Group I, intervention group) Computer, Learning, Knowledge, Information Processing, Pharmacy https://www.ijper.org/article/53/4/638-648 2026-04-20T10:15:16.165724+00:00 Impact of R and D Intensity, Patents and Regulatory Filings on Export Intensity of Indian Pharmaceutical Industry 2019-09-18 10.5530/ijper.53.4.125 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4-638.pdf R and D is necessary for growth of hi-tech sectors like pharmaceuticals and is aimed at boosting innovation. Innovation brings new products that could earn revenues to further boost R and D. Indian pharmaceutical industry earns nearly sixty percent of its revenues from exports and is a leader in global generics market with largest share of ANDA and DMF filings. Significant increase in patenting activity is also observed post India’s accession to TRIPS agreement in 1995 and subsequent introductio Indian pharmaceutical industry, R and D intensity, Export intensity, Innovation, and export intensity, Patents https://www.ijper.org/article/53/4/682-687 2026-04-20T10:19:34.809159+00:00 Fluorometric and Docking Analysis of the Complex Formation between an Anti-cancer Drug, Chlorambucil and Bovine Serum Albumin 2019-09-18 10.5530/ijper.53.4.131 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4-682.pdf Background: To characterize the interaction between chlorambucil (CHB) and the carrier protein, bovine serum albumin (BSA) in order to understand the transport of this drug in blood circulation. Methods: Fluorescence quenching titration method was used to examine the interaction of CHB with BSA by determining its binding constant and binding stoichiometry. The binding site identification was probed with molecular docking techniques. Results: Values of the Stern-Volmer constant (KSV), bimolecular Bovine serum albumin, Chlorambucil, Drug-protein interaction, Fluorescence, quenching, Molecular docking https://www.ijper.org/article/53/4/703-709 2026-04-13T05:55:02.455561+00:00 Anticancer activity of Ipomoea carnea on Ehrlich Ascites Carcinoma Bearing Mice 2019-09-18 10.5530/ijper.53.4.134 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4-703.pdf The current study was aimed to study the anticancer potential of Ipomoea carnea towards Ehrlich ascites carcinoma (EAC) bearing mice. Ethanolic extract of Ipomoea carnea (leaves) was assessed for in vivo anticancer potential. The albino mice of either sex separated into five groups of six animals each. Group I served as normal control, group II served as tumor control, group III and IV animals received different concentrations of plant extract of tumor inoculation (150 mg/kg.bw, 300mg/kg.bw) aft Ipomoea carnea, Ehrlich ascites carcinoma, Albino mice, Ascites fluid, Anticancer activity https://www.ijper.org/article/53/4/670-674 2026-04-13T05:55:02.455561+00:00 In vitro Anti-atherothrombosis Activity of Nigella sativa Oil, Phytol and their Combinations 2019-09-18 10.5530/ijper.53.4.129 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4-670.pdf Background: Black seed oil and Phytol (PHY) are evident for their promising biological effects in various test systems. Aim: This study evaluates anti-atherothrombosis activity of Nigella sativa oil (NSO) and Phytol (PHY). Materials and Methods: The clotlysis activity of the NSO and/or PHY has been investigated by taking Streptokinase (SK) as a standard clotlysis drug. Results: The results suggest that the NSO and PHY exhibited a concentration-dependent clotlysis activity in human clotted blood. Nigella sativa oil, Phytol, Antioxidant, Atherothrombosis, Cardiovascular, diseases https://www.ijper.org/article/53/4/695-702 2026-04-20T10:20:50.999811+00:00 Neuroprotective and Antiapoptotic Effects of N-acetylcystein and Crocus sativus Aqueous Extract on Arsenic-induced Neurotoxicity in SH-SY5Y Human Dopaminergic Neuroblastoma Cells 2019-09-18 10.5530/ijper.53.4.133 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4-695.pdf Background: Parkinson’s disease is mainly specified by progressive and selective death of dopaminergic neurons. Crocus sativus L. (saffron) has been widely used to cure a diverse range of diseases in herbal medicine. Aim: The aim of the present study is to investigate the neuroprotective effects of saffron on arsenic-induced neurotoxicity, which was performed in human neuroblastoma SH-SY5Y cell line as an in vitro model of Parkinson’s disease and to confirm whether the neuroprotective effects of Parkinson Disease, N-acetylcysteine, Saffron, Arsenic, SH-SY5Y cells https://www.ijper.org/article/53/4/649-653 2026-04-13T05:55:02.455561+00:00 Undergraduate Pharmacy Student Perceptions of Tutorial in a Pharmacology of Antibiotics Course 2019-09-18 10.5530/ijper.53.4.126 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4-649.pdf Introduction: This study aims at introducing a modified tutorial activity as part of learning and teaching activity in pharmacology of antibiotic course and collecting student perceptions about this tutorial. Methods: A total of 163 students were divided into smaller groups consist of 13-14 student per group. Tutorial questions were given a week before the face to face session with their tutor. Students answered 2 sets of tutorial questions and attended 2 face to face tutorial sessions before th Pharmacy education, Face-to-face tutorial, Active learning, Guided learning, Pedagogy https://www.ijper.org/article/53/4/603-612 2026-04-13T05:55:02.455561+00:00 The Development and Implementation of Innovative Learning Resource with Guided Projects for the Teaching of Carboxylic Acid Topic 2019-09-18 10.5530/ijper.53.4.121 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4-603.pdf Background: The development of good learning resources in line with current technology to facilitate active learning has become a trend in education. An innovative learning material is believed to be able to motivate the students to learn and to improving students’ skills for chemistry and pharmacy students to handle chemical reaction. Objectives: The study aimed to enact an innovative learning material with guided project to be implemented as learning resources to improve student’s performance Innovative learning resource, Guided project, Independent learner, Chemistry, teaching, Students’ performance https://www.ijper.org/article/53/4/675-681 2026-04-20T10:18:17.564923+00:00 Role of Testosterone in Swimming Exercise-induced Analgesia in Rats 2019-09-18 10.5530/ijper.53.4.130 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4-675.pdf Objective: “Feel good effect” of exercise is well known. Activation of pain inhibitory mechanisms after exercise is also well documented. Swimming is considered as a beneficial exercise as well as health-promoting sport. The significance of testosterone in swimming exercise-induced analgesia is yet to be understood. Therefore, it is worthwhile to investigate the significance of testosterone in swimming exercise-induced analgesia. Materials and Methods: The basal tail flick latencies of all anima Castration, Swimming exercise, Pain threshold, Testosterone, Endogenous, opioids https://www.ijper.org/article/53/4/569-576 2026-04-20T10:12:11.995447+00:00 Prevalence and Pharmacotherapeutic Management of Pediatric Psoriasis–A Descriptive Review 2019-09-18 10.5530/ijper.53.4.118 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4-569.pdf Psoriasis is an auto-immune chronic inflammatory skin disease, which affects about 3.5% of the world’s population. Prevalence of psoriasis among children aged 0 to 18 years is 1% in the United State of America, 5.3% in eastern Saudi Arabia and is on constant rise in other parts of the world. An effective treatment of psoriasis in children may often be challenging mainly because of the lack of established therapeutic guidelines. The objective of this review, therefore, is to provide an update on Psoriasis, Pediatric, Rational, Autoimmune disease, Dermatological, Prevalence https://www.ijper.org/article/53/4/613-619 2026-04-13T05:55:02.455561+00:00 Preliminary Evaluation of a Reform of Methods to Teach Pharmaceutical Polymer Materials Science to a Class of Diverse Majors 2019-09-18 10.5530/ijper.53.4.122 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4-613.pdf Objective: Pharmaceutical polymer materials science is a new discipline that integrates the fields of materials science, polymer chemistry, polymer physics and pharmaceutical preparation and it is an indispensable part of modern pharmacy. This study aimed to improve the quality of teaching pharmaceutical polymer materials science to a class of mixed majors. Materials and Methods: We reformed the teaching content and methods of the pharmaceutical polymer materials course at Southwest University a Pharmaceutical polymer materials science, Teaching reform, Teaching, method, Teaching quality, Multi-professional classroom https://www.ijper.org/article/53/4/663-669 2026-04-20T10:17:00.079595+00:00 Preparation and in vitro and in vivo Evaluation of Chitosan-Gliclazide Mucoadhesive Microparticles by an Emulsification-Desolvation-Crosslinking Technique 2019-09-18 10.5530/ijper.53.4.128 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4-663.pdf Introduction: Recently much emphasis is being laid on the development of microparticles because of their potential benefits such as increased bioavailability, reduced risk of systemic toxicity, reduced risk of local irritation and predictable gastric emptying. Objective: The objective of the present study is to prepare and evaluate mucoadhesive microparticles of chitosan-gliclazide for oral controlled release. Methods: A new method namely emulsification-desolvation-crosslinking was used for the Mucoadhesive microparticles, Chitosan, Gliclazide, Emulsificationdesolvation-crosslinking method, Oral controlled release https://www.ijper.org/article/53/4/620-628 2026-04-13T05:55:02.455561+00:00 Misuse of Competencies in Pharmacy Curriculum: The Spain Case Study 2019-09-18 10.5530/ijper.53.4.123 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4-620.pdf Background: Pharmacy curriculum must prepare students with the necessary competencies to respond to society health-related needs. Aim: This study aims to analyze the allocation of competencies that pharmacists should acquire during their education in the courses constituting pharmacy curricula in Spain. Materials and Methods: All mandatory undergraduate pharmacy courses from all Spanish universities were analyzed in accordance with the official Spanish competency framework. Information about cou Competencies, Competency framework, Curriculum, Pharmacy colleges, Spain https://www.ijper.org/article/53/4/654-662 2026-04-20T10:16:11.496818+00:00 Formulation and Characterization of pH Induced in situ Gels Containing Sulfacetamide Sodium for Ocular Drug Delivery: A Combination of Carbopol®/ HPMC Polymer 2019-09-18 10.5530/ijper.53.4.127 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4-654.pdf Introduction: Topical delivery of eye drops which currently accounts to 90% of available ocular dosage forms are ideal for the treatment of eye diseases but having limitations of poor therapeutic response and low bioavailability. Objectives: The objectives of present research was to develop and characterize sustained release in situ ocular gels containing sufacetamide sodium using pH induced gelling polymers for improved therapeutic response and patient compliance. Methods: In situ gel formulati In situ gel, Ocular, Sulfacetamide sodium, Carbopol®, /HPMC, In-vitro release, Antimicrobial efficacy https://www.ijper.org/article/53/4/710-715 2026-04-13T05:55:02.455561+00:00 Sevoflurane Versus Isoflurane for Postoperative Cognitive Dysfunction of Patients Undergoing Major Cardiac Surgeries: A Prospective Cohort Study 2019-09-18 10.5530/ijper.53.4.135 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4-710.pdf Background: Postoperative cognitive dysfunction is a complication associated with low quality of life in patients receiving major cardiac surgeries. Postoperative cognitive dysfunction due to inhaled anesthesia is not well established. The objective of the present study was to compare the incidence of postoperative cognitive dysfunction in patients undergoing major cardiac surgeries anesthetized with isoflurane or sevoflurane. Materials and Methods: The observational study conducted in a teachin Cardiac surgical procedures, Postoperative cognitive dysfunction, Isoflurane, Mini-Mental State Examination, Sevoflurane https://www.ijper.org/article/53/4/688-694 2026-04-20T10:20:04.652555+00:00 Toxicological Studies of Chaturmukha Rasa, an Ayurvedic Formulation 2019-09-18 10.5530/ijper.53.4.132 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-4-688.pdf Objectives: Chaturmukha Rasa is aspecial, Ayurvedic mercurial preparation broadly used by local practitioners and traditional healers. This research is an endeavour to perform acute and chronic oral toxicity assessment of Chaturmukha Rasa along with an adjuvant Erandapatra (solidified aqueous extract of Ricinus communis Linn.) in wistar rats. Methods: Oral acute toxicity study was performed at 2000mg/kg orally, which was considered as limit dose. The chronic toxicity study was carried out with a Chaturmukha Rasa, Erandapatra, Ricinus communis, Bhasma, Toxicity https://www.ijper.org/article/53/3s/s239-s245 2026-04-13T05:55:03.318018+00:00 An Innovative Approach in Developing Sustained Release Matrix Tablets using Isolated and Characterized Novel Ceasalpinia sappan L. Seed Galactomannan 2019-08-12 10.5530/ijper.53.3s.93 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-239.pdf Introduction: The aim of the study is to develop a galactomannan-based drug delivery system. In this work galactomannan, a biocompatible polymer was isolated from a novel plant source. The seeds of the indigenous plant Caesalpinia sappan L. of the family Caesalpiniaceae were used for the extraction of galactomannan. Materials and Methods: The galactomannan was extracted by maceration and then purified. The purified polymer was characterized by physicochemical methods, FTIR studies, DSC study, SE Caesalpinia sappan, Galactomannan, Sustained drug release, Rheology, Thixotropy, Gum, Herbal formulation https://www.ijper.org/article/53/3s/s325-s331 2026-04-13T05:55:03.318018+00:00 Molecular Docking Studies of Novel Furan-azetidinone Hybrids as Potential Inhibitors of Escherichia coli 2019-08-12 10.5530/ijper.53.3s.102 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-325.pdf Escherichia coli is the predominant gram negative bacteria responsible for a variety of hospital-acquired infections and urinary tract infections. As the bacterial strains are rapidly acquiring resistance to the available antibiotics, there is a need to discover novel antibacterial agents with different scaffolds. In this study, sixteen novel furan derivatives containing the azetidinone moiety were designed and synthesized to arrive at potentially effective antibacterial agents. In silico antiba Furan, Azetidinone, E. coli, Docking, Anti-bacterial activity https://www.ijper.org/article/53/3s/s338-s346 2026-04-13T05:55:03.318018+00:00 New Bioanalytical HPLC Method for the Determination of Cyproheptadine Hydrochloride in Human Plasma and its Application to Rat Pharmacokinetic Study 2019-08-12 10.5530/ijper.53.3s.104 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-338.pdf Background: Cyproheptadine HCl is a serotonin antagonist and histamine H1 blocker agent. Objective: The objective of the present work was to establish a rapid, sensitive and validated bioanalytical HPLC method using Liquid extraction technique for the determination of Cyproheptadine Hydrochloride in human plasma and its application to rat pharmacokinetic study. Methodology: For development of analytical method, Cyproheptadine HCl was estimated in human plasma after liquid liquid extraction using Cyproheptadine HCl, Oxcarbazepine, Bioanalytical method, LLE, HPLC https://www.ijper.org/article/53/3s/s416-s422 2026-04-13T05:55:03.318018+00:00 Wound Healing Activity of Gel Formulated Leaves Extract of Neolamarckia cadamba (Roxb) Bosser 2019-08-12 10.5530/ijper.53.3s.114 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-416.pdf Background: Wound occurs when integrity of the skin is compromised. Healing of wounds occur in various phases namely hemostasis, inflammation, proliferation, granulation, contracture remodelling. Neolamarckia cadamba leaves had been used by the tribal people for the treatment of wounds. Objectives: To formulate a gel of Neolamarckia cadamba which contains carbopol 934 as a gelling agent and to determine its wound healing activity by topical application of gel of Neolamarckia cadamba on surgicall Neolamarckia cadamba, Wound Healing, Excision, Incision, Megaheal gel https://www.ijper.org/article/53/3s/s332-s337 2026-04-13T05:55:03.318018+00:00 In silico Docking Analysis of Active Biomolecules from Cissus quadrangularis L. against PPAR-γ 2019-08-12 10.5530/ijper.53.3s.103 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-332.pdf Introduction: Thiazolidinedione’s are widely used synthetic antidiabetic agents. These agents affect the pumping power of heart muscle due to the formation of edema; limiting their usage in patients with congestive heart failure. The current study was aimed to perform in silico docking study of bioactive phytoconstituents from Cissus quadrangularis Linn. against the target Peroxisome proliferator-activated gamma (PPAR-γ). Materials and Methods: The docking study was performed by using AutoDock 4 Cissus quadrangularis, Diabetes Mellitus, Lipinski rule of five, Molecular, Docking, PPAR-γ https://www.ijper.org/article/53/3s/s437-s450 2026-04-20T10:09:23.092278+00:00 In-silico Designing, Synthesis, SAR and Microbiological Evaluation of Novel Amide Derivatives of 2-(3-methylbenzo[b]thiophen-6-yl)-1- (3-nitrophenyl)-1H-benzo[d]imidazole-5-carboxylic Acid 2019-08-12 10.5530/ijper.53.3s.117 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-437.pdf Aim/Background: Due to this increasing problem of antibiotic resistance, the number of different antibiotics available is dwindling and there are only a handful of new antibiotics in the drug development pipeline. Therefore, there is an urgent need for the development of new antimicrobial drugs. In the present study, we have synthesized and investigated antimicrobial activities of novel derivatives with molecular docking studies. Methods: In this article, amide derivatives of 2-(3-methylbenzo[b] Benzimidazole, Molecular Docking, 1wny.PDBQT, 1jil.PDBQT, Antimicrobial, Activity https://www.ijper.org/article/53/3s/s404-s415 2026-04-13T05:55:03.318018+00:00 Thyroid Health and its Correlation to Female Fertility: A Pilot Study 2019-08-12 10.5530/ijper.53.3s.113 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-404.pdf Background: Most of the problems in female reproductive system are due to dysfunction in hypothalamic-pituitary-ovarian axis. Our study is evaluating thyroid profile in the presence and absence of autoantibodies and how it effect the fertility of Omani women, through serum thyroid evaluation, estimation of prolactin level, autoantibodies and women fertility characteristics. Materials and Methods: This is a clinical cross sectional study, involves systemic random sampling of 182 patients women ag Infertility, Hypothyroidism, Hyperthyroidism, Thyroid profile, Female https://www.ijper.org/article/53/3s/s380-s386 2026-04-20T10:04:58.133694+00:00 Method Development and Validation for Quantitative Estimation of Calcium Acetate in Calcium Acetate Capsules by RP-HPLC using Indirect UV Method 2019-08-12 10.5530/ijper.53.3s.109 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-380.pdf Objective: A simple, accurate and economical method has been developed by Reverse Phase High Performance Liquid Chromatography (RP-HPLC) using indirect UV (Ultra Violet) method. The Principle behind the indirect UV method was applied; the copper sulfate pentahydrate with UV absorption in the mobile phase was replaced with calcium ions without UV absorption, resulting in a reduction in UV absorption of the mobile phase. Materials and Methods: Method development was carried out on strong cation ex Calcium Acetate, RP-HPLC, Indirect UV method, Chromophore, Validation https://www.ijper.org/article/53/3s/s213-s224 2026-04-13T05:55:03.318018+00:00 Systematic Development with Quality by Design Approach of Effervescent Floating Multiple Unit Minitablets of Metoprolol Succinate using Hydrophobic Grade of Gelucire 2019-08-12 10.5530/ijper.53.3s.90 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-213.pdf Objective: The objective of this study was to systematically develop with Quality by Design (QbD) approach of Effervescent Floating Multiple unit Minitablets (EFMM) of metoprolol succinate (MS) for once-a-day dosing using hydrophobic grade of gelucire in order to increase gastric residence time. Methods: Risk assessment using Failure Mode Effect Analysis (FMEA) was conducted and further screened using taguchi design. A Box-Behnken Design (BBD) was adopted for the process of optimization. The dis Risk assessment, Failure mode effect analysis, Taguchi design, Box-Behnken, design, Stability study https://www.ijper.org/article/53/3s/s246-s254 2026-04-13T05:55:03.318018+00:00 Extended Release Floating Microballoons Containing Clerodendrum colebrookianum Extract: In vitro in vivo Evaluation 2019-08-12 10.5530/ijper.53.3s.94 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-246.pdf Aims: Microballoons are floating particulate system comprising of a hollow core, drug being loaded within the polymeric layer. The aim of the study was to prepare microballoons containing extract of Clerodendrum colebrokianum, as bioactive agent. Methods: The microballoons were prepared by solvent diffusion technique, prepared microballoons were physico-chemically characterized (Scanning Electron Microscopy (SEM), buoyancy determination, entrapment efficiency, etc), in vitro drug release study a Microballoons, Antihypertensive agent, Encapsulation, Floating drug delivery, system, 2K1C hypertension induction method https://www.ijper.org/article/53/3s/s423-s432 2026-04-13T05:55:03.318018+00:00 Synthesis and Evaluation of Insecticidal Activity of Bis-Semicarbazones and Bis-(5-Aryl Substituted-1, 3, 4-Oxadiazole) 2019-08-12 10.5530/ijper.53.3s.115 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-423.pdf Background: Various substituted semicarbazones and oxadiazols have been widely investigated for their insecticidal and pharmacological activities. Heterocyclic analogs of these types were extensively studied for their biological activities. In this study insecticidal activity of semicarbazones and oxadiaziole created our interest to prepare and screen the activity. Objectives: To prepare a series of substituted semicarbazones and oxadiazoles, with an observation to subjecting them for insecticid Semicarbazone, Oxadiazole, Insecticidal activity, Biological activity, AutoDock https://www.ijper.org/article/53/3s/s364-s372 2026-04-20T10:03:46.572141+00:00 Simultaneous Determination of Canagliflozin and Metformin in Human Plasma by LC–MS/MS Assay and its Application to a Human Pharmacokinetic Study 2019-08-12 10.5530/ijper.53.3s.107 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-364.pdf Objective: The main objective of this work was to develop a simple, rapid and sensitive liquid chromatography/tandem mass spectrometry (LC–MS/MS) method for the simultaneous quantification of Canagliflozin and Metformin. Methods: Deuterated compounds of respective drugs were used an internal standard. Sample extraction was carried out using a simple Protein Precipitation (PP) technique. A C18 column with an isocratic mobile phase composed of 5mM ammonium acetate with 0.01% formic acid and methan Canagliflozin, Metformin, Human Plasma, LC–MS/MS, Method Validation, Pharmacokinetics https://www.ijper.org/article/53/3s/s225-s230 2026-04-13T05:55:03.318018+00:00 Experimental Data of Fabricated Co-crystals of Doxorubicin HCl with Flavonoids 2019-08-12 10.5530/ijper.53.3s.91 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-225.pdf Objectives: This current research work aimed for improvement of the solubility and permeability of poorly permeable Doxorubicin HCl through generating co-crystals. The main goal for the preparation of oral drugs is to decrease the overall cost of healthcare and route of administration is made easy. Methodology: In this study co-crystals of Doxorubicin HCl with Quercetin hydrate and Naringin has been prepared based on ease of hydrogen bond formation. The co-crystal batches of Doxorubicin HCl-Quer Doxorubicin HCl, Quercetin hydrate, Naringin, Cocrystals, HPLC, Solid state, characterisation, Saturated solubility https://www.ijper.org/article/53/3s/s313-s324 2026-04-20T09:58:58.898365+00:00 Design, Synthesis and Biological Evaluation of Novel Piperidinyl Chalcones 2019-08-12 10.5530/ijper.53.3s.101 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-313.pdf Aim/Background: Chalcones are one of the important class of compounds possessing a wide range of biological properties [Dinmock 1999, Go 2005]. One of the extensive area in research on chalcones is expressed in terms of their ability to act on various cancer cell lines by a variety of molecular mechanisms. Chalcones possessing methoxy groups, a trimethoxy substituted chalcone (PGHSD 234) is the most potent chalcone with cytotoxicity comparable to the standard drugs. Materials and Methods: The an Chalcones, Piperidinyl, Cancer, CDK2/Cyclin A, Docking https://www.ijper.org/article/53/3s/s255-s263 2026-04-13T05:55:03.318018+00:00 Evaluation of Bioactive Metabolites Isolated from Endophytic Fungus Chaetomium cupreum of the Plant Mussaenda luteola 2019-08-12 10.5530/ijper.53.3s.95 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-255.pdf Background: Endophytic fungi are one of the most promising resources of natural bioactive products. In the present study, secondary metabolites were isolated from the endophytic fungus Chaetomium cupreum and evaluated in vitro for pharmaceutical potentials. Objective: To characterize the secondary metabolites obtained from the endophytic fungus Chaetomium cupreum from the plant Mussaenda luteola and to determine its antioxidant, cytotoxicity and anti-mycobacterial activities. Methods: Three seco Endophytic fungi, Chaetomium cupreum, Secondary metabolites, Antimycobacterial, Antioxidant https://www.ijper.org/article/53/3s/s299-s312 2026-04-20T09:58:21.139154+00:00 Fingerprint Based Two-dimensional QSAR Studies on Pyrazolo Quinazolines as CDK2 Inhibitors: A Rational Approach for the Design of Novel Anticancer Agents 2019-08-12 10.5530/ijper.53.3s.100 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-299.pdf Aim/Background: Quantitative structure activity relationship studies are important ligandbased methods used in drug discovery process. The development of Quantum mechanics and its application in the study of smaller and macromolecules have accelerated their applications in the field of drug discovery. Extensive developments in QSAR studies (either 2D or 3D) could be the result of progressive applications of Quantum mechanics. Latest drug discovery modules depends solely on the advanced computati 2D QSAR, Binary fingerprints, Features, Similarity, Kernels, Statistical https://www.ijper.org/article/53/3s/s373-s379 2026-04-13T05:55:03.318018+00:00 Method Development and Validation of Ciprofloxacin HCl and Ornidazole by UFLC in Combined Dosage Form 2019-08-12 10.5530/ijper.53.3s.108 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-373.pdf Background: The combination of Ciprofloxacin and Ornidazole is used for the effective treatment of intra-abdominal infections. Many branded and generic combined dosage formulations of Ciprofloxacin and Ornidazole are available in market. Objective: To develop and validate rapid, sensitive, simple and accurate reverse phase ultra-fast liquid chromatographic method for the determination of Ciprofloxacin and Ornidazole in combined dosage forms. Methods: The separation was carried out by using Pheno Ciprofloxacin HCl, Ornidazole, Intra-abdominal infections, Ultra-fast, PDA, detector https://www.ijper.org/article/53/3s/s273-s279 2026-04-13T05:55:03.318018+00:00 Pharmacokinetic and Pharmacodynamics Interaction between Syzygium cumini and Glipizide: Role of Cytochrome P450 Enzyme 2019-08-12 10.5530/ijper.53.3s.97 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-273.pdf Background: Concomitant administration of herbs and synthetic drugs causes pharmacokinetic and pharmacodynamic interactions. Objectives: To investigate pharmacokinetic and pharmacodynamic interactions between Syzygium cumini (S. cumini, SC) and Glipizide (GZ) and the role of cytochrome P450 (CYP) enzymes in interaction. Methods: The effect of the aqueous seed extract of S. cumini (50 and 100 µg) on CYP3A was studied using in vitro liver microsomes. The interaction of GZ, a second-generation sulp Herb–drug interactions, Type 2 diabetes mellitus, Pharmacokinetics, LCMS, CYP3A https://www.ijper.org/article/53/3s/s288-s298 2026-04-13T05:55:03.318018+00:00 Pharmacoinformatic Studies on 4-Thiazolyl-phenoxy Tail Containing Indanyl Acetic Acid Derivatives as PPAR-Pan Agonists as Potent Anti-Diabetic Agent 2019-08-12 10.5530/ijper.53.3s.99 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-288.pdf Aim: The increasing incidences of type 2 diabetes mellitus, represents a considerable public health problem and characterized by loss in sensitivity of tissues to insulin which can be restored by activation of Peroxisome Proliferator-Activated Receptors (PPARs). The present work takes in consideration for the development of PPAR agonists, which can activate PPARs and is expected to lower LDL cholesterol and triglycerides, raise HDL cholesterol and normalize hyperglycaemia. Materials and Methods: Quantitative structure-activity relationship, Multiple Linear Regression, Molecular docking, Drug Likeness, Hydrogen-bonding interaction https://www.ijper.org/article/53/3s/s347-s355 2026-04-13T05:55:03.318018+00:00 32 Factorial Design for Optimization of HPLC-UV Method for Quantification of Gallic acid in Lohasava and Pippalyasava 2019-08-12 10.5530/ijper.53.3s.105 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-347.pdf Background: A new, simple, accurate and precise High Performance Liquid Chromatographic method (HPLC-UV) has been developed and validated in accordance with ICH guidelines for the determination of gallic acid in Lohasava and Pippalyasava. The developed method was optimised using 32 full factorial design by evaluating the effect of two independent variables i.e. mobile phase composition and flow rate on the various chromatographic responses such as retention time, area, number of theoretical plat Gallic acid, Factorial design, Method validation, HPLC-UV, Quality by Design https://www.ijper.org/article/53/3s/s399-s403 2026-04-13T05:55:03.318018+00:00 The Role of Lifestyle Choices among Female Patients for Prevention of Coronary Artery Disease 2019-08-12 10.5530/ijper.53.3s.112 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-399.pdf Objectives: There was limited data available regarding the effect of daily lifestyle choices in female patients suffering from Coronary Artery Disease (CAD). It had been found that lifestyle played a critical role in the prevention of CAD. It was evident that risk of CAD could be reduced by modifying lifestyle factors like physical activity, drinking, smoking, food, sleep patterns, etc. These were the most effective approaches to strengthen lifestyle factors. Methodology: Women from various occu Coronary artery disease, Lifestyle, Physical activity, Smoking, Drinking https://www.ijper.org/article/53/3s/s280-s287 2026-04-20T09:56:11.373581+00:00 Antibacterial Activity with Bacterial Growth Kinetics and GC-MS Studies on Leaf and Tuber Extracts of Arisaema tortuosum (Wall.) Schott 2019-08-12 10.5530/ijper.53.3s.98 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-280.pdf Background: Pathogenic bacteria (Gram positive/Gram negative) are serving as a vital precursor for the development of infectious diseases in humans. Arisaema tortuosum (Wall.) Schott (ATWS), a famous folklore medicine of Asian region has documented for great medicinal values. Objective: To evaluate the ATWS extracts and their fractions (leaf and tuber part) for antibacterial potential against human pathogens and to probably examine the phytochemicals existing in promising extracts via gas chroma Arisaema tortuosum, Leaf, Tuber, Extracts, Antibacterial activity, GC-MS, analysis https://www.ijper.org/article/53/3s/s433-s436 2026-04-13T05:55:03.318018+00:00 Pharmacological Modulation of Flavivirus Methyltransferase Activity of Dengue Virus (DEV) 2019-08-12 10.5530/ijper.53.3s.116 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-433.pdf Background: The occurrence of dengue fever plagues has expanded significantly in the course of the most recent couple of decades. Be that as it may, no immunization or antiviral treatments are accessible. In this manner, the requirement for protected and successful antiviral medications have turned out to be essential. Aim: Methyltransferases, with their altered enzymatic action, have been found associated with several diseases or infections. It has been observed that the dengue virus infection Methyltransferase, Dengue virus, Inhibitor, Concentration, Time course https://www.ijper.org/article/53/3s/s387-s391 2026-04-13T05:55:03.318018+00:00 Evaluation of Alpha Glucosidase Inhibitor (Miglitol) for its Efficacy in Constipation Associated with Diabetes 2019-08-12 10.5530/ijper.53.3s.110 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-387.pdf Objectives: Recently, miglitol emerged as effective α-glucosidase inhibitor for the treatment of diabetic mellitus with specific advantages over currently available class of antidiabetic drugs. The aim of the present study was to evaluate the effects of miglitol in diabetes and associated constipation. Methods: Diabetes was induced in Wistar albino rat by streptozotocin given at dose of 25mg/kg, i.p. for 3 days consecutively to develop diabetes complications during next four weeks. The drugs wer Miglitol, Diabetes, Constipation, Gastrointestinal motility, α- amylase enzyme, activity https://www.ijper.org/article/53/3s/s264-s272 2026-04-20T09:53:34.626202+00:00 Investigations on Apoptotic Activities of Cherry Laurel Extracts in HCT-116 Human Colon Carcinoma Cells 2019-08-12 10.5530/ijper.53.3s.96 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-264.pdf Background: Cherry laurel fruits are characterized by their dark color and rich phenolic contents. Previously, phenolic extracts from cherry laurel varieties were shown to demonstrate anti-proliferative activities against cancerous cell lines. Aim: To characterize the phenolic compound content of cherry laurel varieties since their characterization is incomplete and determine their apoptotic potential. Methods: The phenolic compounds of fruit extracts from 3 different cherry laurel varieties wer Cherry laurel, Phenolic compounds, Flow cytometry, Apoptosis, LC-MS/MS, analysis, Anthocyanins https://www.ijper.org/article/53/3s/s231-s238 2026-04-20T09:51:14.813124+00:00 Solubility Augmentation of Simvastatin by using the Marvelous Carrier Hydroxy Propyl β-cyclodextrin: Compatibility Study, Statistical and Spectral Analysis 2019-08-12 10.5530/ijper.53.3s.92 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-231.pdf Objective: The poor solubility which causes the poor bioavailability of simvastatin is an arduous task for the preparation of oral dosage form, which can be increased by the preparation of solid dispersion. Materials and Methods: The solid dispersions of simvastatin were prepared in different ratios by physical mixture method, kneading method and melting method using PEG 6000, β-cyclodextrin and Hydroxy Propyl β-cyclodextrin to enhance the solubility of poorly soluble drug. Results: These solid Solid dispersion, HP β-cyclodextrin, PXRD, HMG Co A reductase, complexation https://www.ijper.org/article/53/3s/s356-s363 2026-04-13T05:55:03.318018+00:00 Development, Optimisation and Validation of RP-HPLC Method for the Quantification of Resveratrol 2019-08-12 10.5530/ijper.53.3s.106 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-356.pdf Background: Trans-resveratrol is a naturally occurring polyphenolic compound extensively marketed as a nutraceutical. It is highly explored molecule in the research community with vast therapeutic potential. Therefore, many inventions were made by pharma-industries for its clinical use and to bring it to the market as a drug. Objectives: In this study, a simple, rapid and sensitive Reverse Phase High Performance Liquid chromatographic (RP-HPLC) method for the quantitative determination of resver HPLC, Nanoparticles, Optimization, Resveratrol, Validation https://www.ijper.org/article/53/3s/s392-s398 2026-04-13T05:55:03.318018+00:00 Neuroprotective Effect of Carica papaya Leaf Extract against Aluminium Toxicity: An Experimental Study on Cognitive Dysfunction and Biochemical Alterations in Rats 2019-08-12 10.5530/ijper.53.3s.111 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3s-392.pdf Objective: To study the protective role of alcoholic leaf extract of Carica papaya in aluminium induced cognitive dysfunction and oxidative damage in albino rats and to explore the neuroprotective effect of Carica papaya represented by behaviour and memory tests. Methods: The study was carried out for a period of 42 days (6 weeks) in aluminium chloride induced model. Behavioural assessment is done using Rota rod apparatus and Elevated plus maze and biochemical parameters from brain homogenate li Carica papaya, Neuroprotective, Alzheimer’s disease, Aluminium chloride https://www.ijper.org/article/53/3/435-445 2026-04-13T05:55:05.479645+00:00 Design of Experiments Approach to Discriminatory Dissolution Method Development of Poorly Soluble Drug in Immediate Release Dosage Form 2019-07-21 10.5530/ijper.53.3.76 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3-435.pdf Aim: The study involved design of experiment guided discriminatory dissolution method development for poorly soluble, ezetimibe tablets. Objective: In the current scope of study, ezetimibe tablets are selected as a suitable drug product candidate to evaluate the application of design of experiments in discriminatory dissolution method development for poorly soluble drug. Ezetimibe is practically insoluble in all the aqueous buffers. Methodology: 2-Level factorial design is selected as suitable m DoE, Discriminatory dissolution method, Ezetimibe tablets, DoE aided, dissolution method development https://www.ijper.org/article/53/3/545-552 2026-04-13T05:55:05.479645+00:00 Anti-tubercular Potency and Computationallyassessed Drug-likeness and Toxicology of Diversely Substituted Indolizines 2019-07-21 10.5530/ijper.53.3.87 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3-545.pdf Background: Several promising compounds against multi-drug-resistant Mycobacterium tuberculosis (MTB) are currently in the drug discovery and development pipeline. While it has yet to establish candidature in this pipeline, early results have been promising for the putative anti-mycobacterial potency of the indolizine scaffold. Methods: The molecular properties, as well as the Absorption, Disruption, Metabolism, Excretion and Toxicity (ADMET) of indolizines were assessed using the Accelry's Disc Multi-drug resistant Mycobacterium tuberculosis, In silico, Indolizine, Druglikeness, pharmacokinetics, Toxicity https://www.ijper.org/article/53/3/537-544 2026-04-13T05:55:05.479645+00:00 Effects of Celastrus paniculatus Willd. and Sida cordifolia Linn. in Kainic Acid Induced Hippocampus Damage in Rats 2019-07-21 10.5530/ijper.53.3.86 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3-537.pdf Aim: The purpose of this study was to behavioral and neuroprotective efficacy of Celastrus paniculatus Willd. and Sida cordifolia Linn on hippocampus of the brain in kainic acid induced neurodegenerative diseases. Materials and Methods: A total of 30 albino Wistar rats were randomly divided into five groups: Vehicle control, kainic acid, kainic acid + seed oil of Celastrus paniculatus (SOCP), kainic acid + aqueous root extract of Sida cordifolia (ARESC), kainic acid + SOCP + ARESC. The following Water maze test, Hole board test, Shuttle box test, Neuroprotection, Celastrus paniculatus, Sida cordifolia https://www.ijper.org/article/53/3/503-510 2026-04-13T05:55:05.479645+00:00 Punica granatum and Citrillus colocynthis Aqueous Extracts Protect Mice from LPS-induced Lung Inflammation and Inhibit Metalloproteinases-2 and -9 2019-07-21 10.5530/ijper.53.3.82 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3-503.pdf Aim: Plants used in traditional medicine produce diverse active metabolites exhibiting various medicinal properties. For several centuries Citrillus colocynthis and Punica granatum have been used to treat inflammation, cancer, edema, bacterial infections and diabetes. The objectives of this work were to study the effect of C. colocynthis and P. granatum peel aqueous extracts, on activity of metalloproteinases, enzymes implicated in chronic inflammatory diseases such Chronic Obstructive Pulmonary Lung inflammation, COPD, Emphysema, MMP-2, MMP-9, Mice https://www.ijper.org/article/53/3/527-536 2026-04-13T05:55:05.479645+00:00 Investigating Gastroprotective Potential of Liquisolid Curcumin against the Role of Endogenous Aggressive Factors and Oxidative Stress Markers 2019-07-21 10.5530/ijper.53.3.85 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3-527.pdf Background: The study investigated the efficacy of Liquisolid Curcumin (LSC) over curcumin for gastroprotective action against ethanol induced acute gastric ulcers and the modulation of endogenous oxidative stress markers, in Wistar rats (p.o). Materials and Methods: The experimental design comprised of six groups namely control (Treated with 0.1% w/v CMC), disease control (Treated with absolute ethanol), positive control (Treated with omeprazole; 40 mg/Kg), Test–1 (Treated with curcumin; 50 mg/ Curcumin, Liquisolid curcumin, Liquisolid compacts, Gastroprotection, Oxidative stress markers https://www.ijper.org/article/53/3/511-520 2026-04-20T09:42:26.197535+00:00 Triterpenoid Saponin from Momordica tuberosa (Cucurbitaceae) Stimulates Insulin Secretion from Isolated Mouse Pancreatic Islets and Provides Protection from Streptozotocin and High-glucose Induced Injury 2019-07-21 10.5530/ijper.53.3.83 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3-511.pdf Background: Momordica tuberosa, belonging to the family Cucurbitaceae, is a tropical plant that is widely cultivated in the southern states of India. Objectives: Momordica tuberosa possesses a saponin, triterpenoid in nature that has been reported to exhibit anti-hyperglycaemic activity in vivo and in vitro. In this study we intend to isolate the saponin in pure purified state, assess its anti-hyperglycaemic activity on isolated mice pancreatic islets and evaluate its protective role against str Saponin, Momordica tuberosa, Insulin secretagogue, Islet viability, High, glucose-induced cytotoxicity https://www.ijper.org/article/53/3/480-493 2026-04-13T05:55:05.479645+00:00 Formulation and Stability Studies of Fast Disintegrating Tablets of Amlodipine Besylate 2019-07-21 10.5530/ijper.53.3.80 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3-480.pdf Introduction: Among tablets, fast dissolving technology has gained considerable popularity due to their rapid onset of action. Amlodipine besylate (ADB) is a longacting calcium channel blocker that is used in the treatment of angina and hypertension which are life-threatening conditions and require immediate relief. Currently, no fast dissolving tablet dosage form of ADB is commercially available. Methods: A total of seven fast disintegrating tablets of Amlodipine besylate (ADB) have been prepar Amlodipine besylate, Direct compression, Drug release, Fast disintegrating, tablets, Model dependent and independent methods, Pre-compression and postcompression studies https://www.ijper.org/article/53/3/468-479 2026-04-13T05:55:05.479645+00:00 Development of Capsules Filled with Phenytoin and Berberine Loaded Nanoparticles- A New Approach to Improve Anticonvulsant Efficacy 2019-07-21 10.5530/ijper.53.3.79 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3-468.pdf Introduction: Currently used anticonvulsant drugs are not totally effective to control seizures. Phenytoin is a classic instance where its efficiency is inhibited through high metabolization (90%-95%) and back transport through cytochrome P450 and P-glycoprotein, respectively. To explore and attain improved anticonvulsant efficacy combination therapy with nanotechnology has been adopted in this research. Objective: development of nanotechnology-based drug delivery system by filling berberine and Status epilepticus (SE), Phenytoin, Berberine, Nanoparticles, Cytochrome, P-450, P-Gp efflux transporters https://www.ijper.org/article/53/3/457-467 2026-04-13T05:55:05.479645+00:00 Liquisolid Compact Tablet of Candesartan Cilexetil with Enhanced Solubility using Neusilin US2, Aerosil 200 and Transcutol HP 2019-07-21 10.5530/ijper.53.3.78 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3-457.pdf Objective: An attempt was made to enhance solubility, dissolution and intestinal permeability of drug candesartan cilexetil by liquisolid technology. Methods: Liquisolid tablet was formulated using non-volatile solvent Transcutol HP, carrier material Neusilin US2 and coating material Aerosil 200. Appropriate quantities of excipients were calculated with the help of mathematical model to get liquisolid powder. A 32 full-factorial design was used further to optimize liquisolid powder. Results: DSC Candesartan cilexetil, Transcutol HP, Neusilin, Aerosil 200, Liquisolid, technology, ex-vivo study https://www.ijper.org/article/53/3/366-375 2026-04-13T05:55:05.479645+00:00 Recent Advancement in in-vivo and in-vitro Toxicity Studies for Ayurvedic Formulation 2019-07-21 10.5530/ijper.53.3.70 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3-366.pdf Aim: Ayurvedic formulation consists of natural substance. Many of Ayurvedic formulation consist of heavy metals and some species are poisonous in nature. So it is necessary to determine the toxicity of Ayurvedic formulation. Background: Toxicology is a science that involves the study of the adverse effect of the substance on living organism. The toxicity of the substance can be observed by: a) in vivo (using the whole animal), b) in vitro (Testing on isolated cell or tissue). In vivo toxicity st Ayurvedic formulation, in vivo toxicity, in vitro toxicity, Specific toxicity, Toxicokinetic, Toxicology https://www.ijper.org/article/53/3/446-456 2026-04-13T05:55:05.479645+00:00 Effect of Ethyl Cellulose Content on Release Profile and Pharmacodynamics of Fenoprofen Microparticles 2019-07-21 10.5530/ijper.53.3.77 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3-446.pdf Introduction: Fenoprofen calcium (FC) is a non-steroidal anti-inflammatory drug and due to its short half-life, high absorption, extensive metabolism and adverse effect, sustained release formulation of FC is desired. Objective: this study was to develop sustained release microcapsules of FC to obtain better drug delivery. Material and Methods: Different formulae of FC microcapsules were prepared by o/w emulsion solvent evaporation method using Ethyl cellulose (EC) in three different ratios. The Ethylcellulose, Microencapsulation, Fenoprofen calcium, Sustained release, Pharmacodynamics, Microparticles https://www.ijper.org/article/53/3/494-502 2026-04-13T05:55:05.479645+00:00 Hydrochlorothiazide Nanocrystals Stabilization by Silk Sericin 2019-07-21 10.5530/ijper.53.3.81 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3-494.pdf Aim: The aim of present study deals with preparation and stabilization of Hydrochlorothiazide nanocrystals using silk sericin. Materials and Methods: Nanocrystals of BCS class II drugs were primed by antisolvent precipitation method in ratio of HCTZ: Sericin (1:0.5, 1:1, 1:1.5, 1:2). Further Nanocrystals were investigated by particle size, zeta potential, drug content, ATR- FTIR, XRD, DSC, SEM, in vitro dissolution study and stability study. Zeta potential (1:0.5) shows higher value -18.8 than o Sericin, Stabilization, Lyophilization, Solubility, Antisolvent, Nanocrystals https://www.ijper.org/article/53/3/553-561 2026-04-20T09:45:39.950514+00:00 The Role of Pharmacist in Managing Hypertension in the Community: Findings from a Community Based Study 2019-07-21 10.5530/ijper.53.3.88 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3-553.pdf Introduction: Pharmacist led health education programs have been initiated to improve Blood Pressure (BP) control in the community and patients’ knowledge on a disease and therapy, lifestyle changes and medication adherence among hypertensive patients. This study aimed to evaluate pharmacist led health education program among hypertensive patients, in local community-based setting, by assessing the changes in blood pressure control, beliefs about medicine, antihypertensive medications adherence Pharmacist led education program, Hypertension, Medication adherence, Beliefs about medicine, Quality use of medication https://www.ijper.org/article/53/3/382-399 2026-04-13T05:55:05.479645+00:00 Surface Decorated Mesoporous Silica Nanoparticles: A Promising and Emerging Tool for Cancer Targeting 2019-07-21 10.5530/ijper.53.3.72 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3-382.pdf Background: In nanotechnology, the most promising inorganic materials for cancer targeting are Mesoporous silica nanoparticles (MSNs). This review gives a state of the art description of current status and applications of surface functionalized MSNs in the field of cancer theranostics. It also gives a detailed description of surface decorated MSNs researched upon so far in various types of cancer and the benefits associated with these. Applications: Ease of surface functionalization also offers Mesoporous silica nanoparticles, Cancer targeting, Surface modification, Theranostics, Biomedical Application, Biodegradation https://www.ijper.org/article/53/3/421-434 2026-04-13T05:55:05.479645+00:00 Gap Versus Performance Based Measure of Pharmaceutical Education Service Quality: An Empirical Comparison 2019-07-21 10.5530/ijper.53.3.75 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3-421.pdf Aim/Background: Whether service quality is measured by the gap between expectation and performance or by performance only. In quest of attaining answer of that query, the present research has taken an attempt to compare the efficacy of two varied orientations of service quality estimation empirically in pharmaceutical education service. Materials and Methods: We have surveyed randomly students of pharmaceutical graduation course of the six institutes. We have developed (Employing Exploratory Fac Pharmaceutical Education, Service Quality Measurement, India, SERVQUAL, SERVPERF, Higher Education Service Quality https://www.ijper.org/article/53/3/562-568 2026-04-13T05:55:05.479645+00:00 Knowledge and Attitudes about Ebola Virus Disease among Community Residents in Winchester, Virginia, US 2019-07-21 10.5530/ijper.53.3.89 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3-562.pdf Background: Educating individuals in the community is an important step in helping to improve response to disease outbreaks. This education can help reduce the spread of misinformation during an outbreak. Unfortunately, there is little information in the literature on what factors play a role in the education of individuals in the community. Methods: This cross-sectional study was designed to identify factors that could contribute to the overall knowledge of community members residing in Winches Ebola Virus Disease, transmission, public health, disease outbreaks, humans, health knowledge https://www.ijper.org/article/53/3/414-420 2026-04-20T09:37:10.987731+00:00 Chemistry, Manufacturing and Control (CMC) Evaluations of ANDA Submission in the USA 2019-07-21 10.5530/ijper.53.3.74 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3-414.pdf Background: The Abbreviated New Drug Application commonly referred as ANDA is an application that contains data submitted to US FDA for the review and prospective marketing authorization of generic drugs. The conduct of the reviewing of the application is done by the Division of Filing Review (DFR), Office of Regulatory Operations (ORO) in the Office of Generic Drugs (OGD). The format of ANDA: USFDA recommends the submission of ANDA applications as per ICH Common Technical Document (CTD) format. USFDA, Question-based Review, Chemistry Manufacturing and control, CTD, Module 3 https://www.ijper.org/article/53/3/376-381 2026-04-20T09:34:27.539372+00:00 Pharmacoeconomics Status in Asia and an Emerging Hub in the Indo-Pak 2019-07-21 10.5530/ijper.53.3.71 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3-376.pdf Objective: A review has been carried out to understand pharmacoeconomics and its development in the Asian region. Findings: Pharmacoeconomics is a subset of health economics which applies the methodologies and principles of health economics in clinical decision making. Currently, a number of countries around the globe have implemented pharmacoeconomics in their health care systems. However, the development of pharmacoeconomics in the Asia is very debatable. With countries like South Korea, Japan Asia, Development, India, Pakistan, Pharmacoeconomics, Opportunities https://www.ijper.org/article/53/3/343-354 2026-04-13T05:55:05.479645+00:00 Recent Advances in Vaccine Development for the Treatment of Emerging Infectious Diseases 2019-07-21 10.5530/ijper.53.3.68 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3-343.pdf Background: Malaria, Chikungunya and Dengue are some of the emerging infectious diseases whose incidence has increased in the past 20 years and could increase in the near future. Although many chemotherapeutic agents are available in clinical use, yet there is a need for the development of novel approaches for the treatment of these lifethreatening diseases. Materials and Methods: In this review, we attempt to highlight some advancement in novel vaccine development in the last decade for the cur Vaccine, Malaria, Chikungunya, Dengue, Clinical, Preclinical https://www.ijper.org/article/53/3/521-526 2026-04-13T05:55:05.479645+00:00 Inhibition of Proliferation of Human Prostate Carcinoma Cell, PC3 by Bauhinia racemosa Lam. via Induction of Apoptosis 2019-07-21 10.5530/ijper.53.3.84 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3-521.pdf Background: Prostate cancer is the second foremost cause of cancer death in Western males, the progression of which may be a consequence of defect in apoptotic machinery. Objective: Thus, aim of the study was designed to investigate inhibition of proliferation of human prostate carcinoma cell line, PC3 by Methanolic extract of Bauhinia racemosa Lam (MEBR). Methods: MTT assay was performed to evaluate antiproliferative effect of MEBR on prostate carcinoma cell line while DAPI and DCFH-DA staining Prostate cancer, PC3, Bauhinia racemosa, Apoptosis, Reactive oxygen, species https://www.ijper.org/article/53/3/355-365 2026-04-13T05:55:05.479645+00:00 Development and Application of Lipid Nanotechnology on Infectious Diseases of CNS- Current Scenario 2019-07-21 10.5530/ijper.53.3.69 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3-355.pdf Background: This is an era of inventive technology illuminating fundamental mechanisms of diseases and fabricating drug molecules according to prerequisite condition, but it is still a challenge to target infectious diseases specially in CNS due to various restrictions of drug delivery to the brain and drawbacks of various conventional antimicrobial agents. These are prone to development of multiple drug resistances as sufficient amount of drug cannot reach to the site of infection. Materials an Multiple drug resistance, Solid lipid nanoparticles, Nanostructured lipid, carriers, Lipid drug conjugated nanoparticles, CNS, Blood-brain barrier https://www.ijper.org/article/53/3/400-413 2026-04-13T05:55:05.479645+00:00 Potential of Pure Phytoconstituents and Herbs in Protection of Drug Induced Nephrotoxicity 2019-07-21 10.5530/ijper.53.3.73 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-3-400.pdf Global trend is setting towards improved ‘quality of life’, for that there is considerable evidence of an increase in demand for medicinal plants. According to the WHO report, between 65% and 80% of the populations of developing countries use medicinal plants as remedy nowadays. Kidney is one of the vital organs of body and Nephrotoxicity is one of the most common problems and it occurs as a result when body is exposed to a drug or toxin. This review article aims to report and to introduce the e Nephrotoxicity, Cisplatin, Gentamicin, Natural compounds, Medicinal plants https://www.ijper.org/article/53/2s/s104-s111 2026-04-20T09:21:45.550479+00:00 Medhya Rasayana Restores Memory Function against Doxorubicin-induced Cognitive Decline: Possibly by its Neuroprotective Effect 2019-04-12 10.5530/ijper.53.2s.54 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-104.pdf Background: Medhya Rasayana (MR) is an ayurvedic formulation used to rejuvenate the intellectual functions. It was shown to improve the cognitive function in rats. Hence, the present study was designed to study the neuroprotective effect of MR against Doxorubicin (DOX)-induced cognitive deficits which usually occurs in long-term breast cancer survivors. Methods: The neuroprotective effect of MR was studied in-vitro using IMR-32 cell lines against DOX-induced toxicity while the protective effect Doxorubicin, Medhya Rasayana, Chemobrain, Cognitive dysfunction, Chemotherapy, Novel object recognition task https://www.ijper.org/article/53/2s/s164-s169 2026-04-20T09:26:27.400969+00:00 Total Phenolic and Caffeic Acid Contents in Roots of Solanum indicum L. from Different Agroclimatic Regions of Madhya Pradesh State of India 2019-04-12 10.5530/ijper.53.2s.62 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-164.pdf Introduction: Solanum indicum L. is one of the species of Dashmularishta, a wellestablished ayurvedic medicine used in the treatment of fatigue, oral sores and gynecological disorders. The present investigation dealt with the estimation of total phenolic and caffeic acid contents in roots of S. indicum from different agroclimatic regions of Madhya Pradesh. Materials and Methods: The roots were collected from 8 places of 7 agroclimatic regions of Madhya Pradesh following purposive sampling. Pheno Solanum indicum, Roots, Phenols, Caffeic acid, Agroclimatic regions, Superior chemotypes https://www.ijper.org/article/53/2s/s204-s212 2026-04-20T09:30:07.190859+00:00 Development and Evaluation of a (SEDDS) SelfEmulsifying Drug Delivery System for Darifenacin Hydrobromide 2019-04-12 10.5530/ijper.53.2s.67 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-204.pdf Background: The formulation and development of new chemical entities has the major challenge of low solubility. A fraction of newly manufactured drugs (40%) have poor hydrophilicity. As a result, the delivery of these drugs bioavailability, thus limiting the rate of absorption of hydrophobic drugs. Method: Self-Emulsifying Drug Delivery (SEDDS) system with the poorly hydrophilic drug, darifenacin was developed. We conducted solubility studies to obtain the materials that allowed for the maximum Self-Emulsifying Drug Delivery (SEDDS), Darifenacin, Peanut Oil, Labrafil M, 1944, Polyethylene Glycol 400, Ternary Phase Diagrams https://www.ijper.org/article/53/2s/s50-s57 2026-04-13T05:55:06.445046+00:00 Formulation and Characterization of Controlled Release Flurbiprofen Microsponges Loaded in Gels 2019-04-12 10.5530/ijper.53.2s.48 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-50.pdf Objective: The main objective of this study was to formulate transdermal gels containing Flurbiprofen microsponges for controlled drug delivery. Methods: Microsponges containing Flurbiprofen and ethylcellulose were prepared by the quasi-emulsion solvent diffusion method. By varying the amount of drug and the polymer, seven batches of microsponges were formulated. Microsponges formed were characterized for surface morphology, thermal behavior, drug content, particle size, X-ray powder diffraction Flurbiprofen, Topical, Porous, Microsponges, Controlled release, Quasiemulsion solvent diffusion https://www.ijper.org/article/53/2s/s66-s73 2026-04-20T09:18:34.146273+00:00 Sustained Release Bioadhesive Ocular Inserts of Olopatadine Hydrochloride: Formulation and Characterization 2019-04-12 10.5530/ijper.53.2s.50 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-66.pdf Objective: To develop bioadhesive ocular inserts of Olopatadine hydrochloride for treating the allergic eye conditions with sustained ocular delivery which will reduce dosing frequency. Methods: Matrix type ocular inserts were prepared by the solvent casting technique using teflon coated petri plates and characterized in vitro for drug release studies. Nine formulations were prepared having different ratios of polymers such as carbopol 980P, HPMC K4M and NaCMC (90:10, 70:30 and 50:50) and optimi Olopatadine hydrochloride, Ocular inserts, Solvent casting, Bioadhesive, Drug release https://www.ijper.org/article/53/2s/s179-s185 2026-04-13T05:55:06.445046+00:00 In vitro Metabolism of Risperidone on Isolated Microsomes of Rat Liver: Metabolite Identification and Profiling by RP-HPLC and LC-MS Techniques 2019-04-12 10.5530/ijper.53.2s.64 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-179.pdf Objective: The objective of present research work is to study in vitro metabolism of risperidone on isolated microsomes of rat liver. Methods: Its biotransformation was examined using isolated microsomes derived from rat livers. Their separation was accomplished on Jasco RP-HPLC C-18 column (250mm x 4.6mm x 5µm) using methanol: 50mM Potassium dihydrogen phosphate (50:50 %v/v) mobile phase, detected at a wavelength of 280nm. Results: In vitro metabolism of RIS was investigated using the cytochrom RIS, Microsomes, Cytochrome P450, Biotransformation, LC-MS https://www.ijper.org/article/53/2s/s28-s42 2026-04-20T09:15:23.530541+00:00 Sesamol and Health – A Comprehensive Review 2019-04-12 10.5530/ijper.53.2s.46 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-28.pdf Antioxidant potential of sesamol has led to being studied extensively in recent decades for its beneficial role in vast aliments. There has been a renewed interest in this compound recently, due to its activities such as hepatoprotective, neuroprotective, chemopreventive, anti-inflammatory, cardioprotective, skin protective and antiaging properties which were established in various preclinical models. Further studies may be required to develop its underlying mechanisms and to investigate its var In vitro, in vivo studies, Pharmacokinetics, Sesamol, Synthesis https://www.ijper.org/article/53/2s/s82-s92 2026-04-13T05:55:06.445046+00:00 Piroxicam Loaded Solid Lipid Nanoparticles (SLNs): Potential for Topical Delivery 2019-04-12 10.5530/ijper.53.2s.52 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-82.pdf Aim: The objective of this study was to develop suitable lipid nanocarriers for topical delivery of Piroxicam, known for its anti-inflammatory and anti-arthritic properties and to increase its therapeutic potential and residence time at the site of inflammation and in systemic circulation. Materials and Methods: Piroxicam loaded Solid lipid nanoparticles (SLNs) were prepared by high-speed homogenization followed by ultrasonication technique. Physicochemical evaluation of SLNs involved particle s Solid lipid nanoparticles, Piroxicam, Topical, Inflammation, Dermal https://www.ijper.org/article/53/2s/s121-s128 2026-04-13T05:55:06.445046+00:00 Formulation, Optimization and Evaluation of in-situ Gelling Liquid Oral Formulation of a Novel Antidiabetic Drug: Canagliflozin 2019-04-12 10.5530/ijper.53.2s.56 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-121.pdf Aim: The present research work involves the development and optimization of an in-situ gel forming formulation by face centered central composite response surface design methodology to increase buoyancy and controlled release of a novel antidiabetic drug; Canagliflozin hemihydrate, having absorption window in upper part of gastrointestinal tract. Materials and Methods: The drug and excipient compatibility studies were performed by subjecting to Fourier Transform Infra-red spectroscopy and Differ Gastric retention, Antidiabetic, Canagliflozin Hemihydrate, Sodium Alginate, Optimization https://www.ijper.org/article/53/2s/s186-s192 2026-04-13T05:55:06.445046+00:00 EPR and UV-Vis Spectroscopic Studies of the Influence of Ultraviolet Irradiation on Antioxidant Interactions of Nystatin 2019-04-12 10.5530/ijper.53.2s.65 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-186.pdf The changes of the free radical scavenging activity of nystatin after UV-irradiation were examined. The kinetics of the interactions of nystatin with free radicals was tested. The model DPPH free radicals were used. Free radicals were tested by an X-band (9.3 GHz) electron paramagnetic resonance spectroscopy. The EPR spectra of DPPH and DPPH in contact with non-irradiated and UV-irradiated nystatin were measured. Nystatin quenched the EPR spectra of DPPH free radicals as the result of the antiox Nystatin, Antioxidant, UV-irradiation, EPR, UV-Vis https://www.ijper.org/article/53/2s/s193-s203 2026-04-13T05:55:06.445046+00:00 Screening of Silk Fibroin as a Stabilizer for Freeze Drying of Thermolabile Drug 2019-04-12 10.5530/ijper.53.2s.66 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-193.pdf Aim: In the present research work an attempt is made to investigate use of silk fibroin as a stabilizer for model thermolabile drug Tenofovir Alafinamide Fumarate (TAF). Materials and Methods: On the basis of literature reviewed various lyophilized formulations of TAF using silk fibroin as a stabilizer were prepared. Lyophilized formulations were optimized by analyzing for % drug content, % moisture retention and appearance of lyophilizate and further investigated by using modern techniques such Silk fibroin, Stabilizer, Tenofovir Alafinamide Fumarate, Freeze drying https://www.ijper.org/article/53/2s/s135-s142 2026-04-13T05:55:06.445046+00:00 The Effectiveness of Chitosan- Pinus merkusii Extract Nanoparticle as Antioxidant and Anti-caspase 3 in against Lead Acetate Toxicity on the Lung of Wistar Rat 2019-04-12 10.5530/ijper.53.2s.58 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-135.pdf Background: The antioxidants can be used for protective in oxidative stress that is one of the important mechanisms of lead acetate-induced lung toxicity. Objective: The current study was carried out to evaluate the effectiveness of Chitosan- Pinus merkusii extract nanoparticle as antioxidant and anti-caspase 3 in against lead acetate-induced lung toxicity on wistar rats. Methods: Chitosan- Pinus merkusii nanoparticle were characterized by Dynamic Light Scattering (DLS) and Scanning Electron Mic Chitosan- Pinus merkusii nanoparticle, Antioxidant, Caspase 3, Lead acetate, Lung toxicity https://www.ijper.org/article/53/2s/s170-s178 2026-04-13T05:55:06.445046+00:00 Simultaneous Determination of Hydrophilic and Lipophilic Drugs in Anti-Cancer Liposomes: Absorptivity Method 2019-04-12 10.5530/ijper.53.2s.63 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-170.pdf Background: Dual loaded liposomes have always been a hot topic of investigation because of their therapeutic advantages over single drug regimens. But simultaneous estimation of both the drugs during in vitro and in vivo analysis is most of the times a major obstacle for the researchers. This problem is even bigger when the two drugs are of opposite nature (hydrophilic and lipophilic). Methods: Here, we formulated anti-cancer liposomes loaded with Dacarbazine (hydrophilic) and Eugenol (lipophili UV absorptivity method, Simultaneous determination, Dual loaded liposomes, Suitable solvent system, Method Validation https://www.ijper.org/article/53/2s/s129-s134 2026-04-20T09:23:28.049978+00:00 Synthesis and Characterization of Novel N-Benzylbenzimidazole Linked Pyrimidine Derivatives as Anticancer Agents 2019-04-12 10.5530/ijper.53.2s.57 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-129.pdf Background: Emergence of resistance to accessible anticancer drugs became a threat to human lives in the recent time. To address this issue, discovery of novel anticancer agents becomes very essential. Benzimidazoles and pyrimidines have been reported to possess potent anticancer activity. Materials and Methods: A hybrid approach has been used, in which core structure of potentially active N-benzyl benzimidazole and pyrimidine derivatives are brought together in to a single molecule. The desired Chalcone, Benzimidazole, Pyrimidine, Anticancer activity, SRB assay https://www.ijper.org/article/53/2s/s17-s27 2026-04-13T05:55:06.445046+00:00 Mucoadhesive Nanoparticles: A Roadmap to Encounter the Challenge of Rapid Nasal Mucociliary Clearance 2019-04-12 10.5530/ijper.53.2s.45 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-17.pdf The modulation of mucoadhesion at the nanoscale is a very challenging task before the formulation scientists. Mucoadhesive nanoparticles are endowed with distinct properties such as increased residence, intimate contact of mucoadhesive dosage form at the mucosal surface and reproducible drug absorption. Large surface area, porous endothelial membrane, high total blood flow, ready accessibility, rapid onset of action, low enzyme level compared to gastrointestinal tract and avoidance of hepatic fi Nanomedicine, Nanoparticles, Mucoadhesion, Intranasal, Drug delivery https://www.ijper.org/article/53/2s/s159-s163 2026-04-13T05:55:06.445046+00:00 Development and Evaluation of Polyherbal Lozenges for Cold and Flu 2019-04-12 10.5530/ijper.53.2s.61 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-159.pdf Background: Lozenges are solid dosage form which are intended to slowly dissolve in the mouth for therapeutic effect. Common cold and flu are common diseases which usually infects the respiratory tract including symptoms like head and body ache, fever, drowsiness, runny nose, congestion and cough. Aim: The present polyherbal lozenge formulations developed to eliminate all symptoms of cold and flu. Although many herbal and allopathic drugs are available, but they are not sufficient to treat all t Polyherbal lozenges, Common col, Flu Polyherbal, Lozenges, Formulations, Cold, Flu, Standardization https://www.ijper.org/article/53/2s/s143-s150 2026-04-13T05:55:06.445046+00:00 Structure Based Computational Exploration of Beilschmiedia Compounds with Selected Targets against Multidrug-Resistant Mycobacterium tuberculosis 2019-04-12 10.5530/ijper.53.2s.59 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-143.pdf Aim/Background: Tuberculosis is a serious health issue across the world. Various bioactive molecules show the affects against Multidrug-resistant tuberculosis (MDR-TB). There are various standard drugs developed against Mycobacterium for its treatment. But, the pathogen of tuberculosis is developing resistance towards the various standard. The present study was aimed to determine the effect of Beilschmiedia phytoconstituents against different protein targets of Mycobacterium tuberculosis (MTB). Mycobacterium tuberculosis, Multi-Drug Resistant Tuberculosis, Beilschmiedia, zenkeri, Beilschmiedia anacardioides, Molecular Docking https://www.ijper.org/article/53/2s/s112-s120 2026-04-13T05:55:06.445046+00:00 Biosynthesis, Characterization and Antagonistic Applications of Extracellular Melanin Pigment from Marine Nocardiopsis Sps 2019-04-12 10.5530/ijper.53.2s.55 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-112.pdf Context: Although there is an abundance of several microbial phyla in the oceans actinobacteria have emerged as a major source for natural products. Streptomyces sps is the widely encountered actinobacteria. Lately, Streptomyces are increasingly been used for pigment extraction. Aim: The aim herein was to extract bioactive melanin pigment from rare actinobacteria, which is a not a widespread occurrence. Materials and Methods: Marine samples were collected aseptically from the waters of the Arabi Melanin, Nocardiopsis dassonvillei, Anti-quorum sensing, Anti-biofilm, FTIR https://www.ijper.org/article/53/2s/s93-s103 2026-04-20T09:20:20.628899+00:00 Formulation and Evaluation of Gastro-bilayer Floating Tablets of Ezetimibe as Immediate Release Layer and Atenolol as Sustained Release Layer 2019-04-12 10.5530/ijper.53.2s.53 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-93.pdf Introduction: Combination therapy of ezetimibe and atenolol is highly desirable for better management of dyslipidaemia and hypertension. Ezetimibe has poor solubility hence variable and low bioavailability. Atenolol has poor absorption in lower gastrointestinal tract, short half-life. Therefore, the present study was to develop gastro-bilayer floating matrix tablet in which ezetimibe was incorporated as immediate layer and atenolol as sustained release layer. Methods: Solubility of the ezetimibe Gastro-bilayer, floating, immediate release, sustained release, ezetimibe, atenolol https://www.ijper.org/article/53/2s/s1-s16 2026-04-13T05:55:06.445046+00:00 Recent Developments on Pharmacological Potential of 1,3,4-Oxadiazole Scaffold 2019-04-12 10.5530/ijper.53.2s.44 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-1.pdf Heterocyclic compounds represent the important structural key in pharmaceutical medicinal chemistry. In literature, five-membered heterocycles are reported to be a core moiety of various pharmaceutical drugs. 1,3,4-oxadiazole scaffold, among various five-membered heterocycles is an important molecule which attracts various medicinal chemist to develop a novel biologically active molecule. 1,3,4-Oxadiazole is found to bear important pharmacological activities such as anti-diabetic, antimicrobial, Anti-diabetic, Anti-cancer, Heterocycle, Oxadiazole, Pharmacological activity https://www.ijper.org/article/53/2s/s74-s81 2026-04-13T05:55:06.445046+00:00 Formulation, Development and Evaluation of Nifedipine Emulgel for Treatment of Anal Fissures using Polymeric Emulsifiers 2019-04-12 10.5530/ijper.53.2s.51 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-74.pdf Aim/Background: Nifedipine (NIF) is act as Calcium channel blocker which belongs to chemical class dihydropyridine and used in the treatment of hypertension. An anal fissure (AF) is the most common anorectal conditions encountered in clinical practice. Patient anal fissures experience anal pain with defecation and minor bleeding. Emulgel formulations are considered a combination of emulsion and gels and emulgel has advantages of both. Emulgels have better penetration of actives than conventional Nifedipine, Polymeric emulsifiers (PE), Anal fissures, Emulgel, Evaluation of, emulgel formulation https://www.ijper.org/article/53/2s/s151-s158 2026-04-13T05:55:06.445046+00:00 18β-glycyrrhetinic Acid Protects against Staphylococcus aureus Infection by Regulating the NF-κB Pathway 2019-04-12 10.5530/ijper.53.2s.60 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-151.pdf Background: 18β-glycyrrhetinic acid (18β-GA) is reported to possess various pharmacological properties of which anti-inflammatory activities has been widely explored. However, the role of 18β-GA in Staphylococcus aureus (SA) infection has not been investigated. The aim of the present study was to explore the effects of 18β-GA on the SA infection especially the SA-induced Acute lung injury (ALI) and its related mechanisms. Material and methods: We infected the mice or cells with SA and then detec 18β-glycyrrhetinic acid, Staphylococcus aureus, Acute lung injury, HMGB1, NF-κB https://www.ijper.org/article/53/2s/s43-s49 2026-04-13T05:55:06.445046+00:00 Novel Preparation and Effective Delivery of Mucoadeshive Nanoparticles Containing Anti-diabetic Drug 2019-04-12 10.5530/ijper.53.2s.47 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-43.pdf Background: Vildagliptin is an extensively studied DPP-4 inhibitors (anti-diabetic drug) which has contributed greatly to the understnading of molecular interatcion with the DPP-4 enzyme. However, Vildagliptin exerts glucose- lowering effect transiently due to short elimination half-life of 2- 3 hrs. Consequently, strict adherence to the dosing schedule strongly emphasised to the diabetic patients. In order to sustain therapeutic effects of a drug at site of absorption, recent efforts have focus Burst release, Diabetes mellitus, Nanoparticle, Muoadhesive, Vildagliptin, Spray drying https://www.ijper.org/article/53/2s/s58-s65 2026-04-13T05:55:06.445046+00:00 Effect of Sustained Release Polymers on Drug Release Profile of Aceclofenac TabletsPhysicochemical Properties, Analysis of Kinetics and Fit Factor 2019-04-12 10.5530/ijper.53.2s.49 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2s-58.pdf Aim: The sustained release tablets of Aceclofenac were prepared and evaluated for the sustained release drug profile with an aim to reduce dosing frequency and provide patient compliance. Materials and Method: The tablets were prepared by using different percentages of Kollidon SR, Carbopol 934P and Eudragit L100 and their combination thereof by wet granulation method. The tablets were analyzed for post compression studies including thickness, diameter, mechanical strength and uniformity of cont Aceclofenac, Fit factor, Kinetics, Carobopol, Kollidon, Eudragit L100 https://www.ijper.org/article/53/2/236-241 2026-04-13T05:55:07.521569+00:00 Pharmacokinetic Differences of Three Aconitum Alkaloids from Aconiti lateralis Radix Praeparata and Compatibility with Pinellia in Rats 2019-02-18 10.5530/ijper.53.2.31 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2-236.pdf Aim: This study aims to develop a highly sensitive and specific UPLC-MS/MS method to explore the pharmacokinetic properties of three representative active alkaloids (benzoylhypaconine, benzoylmesaconine, benzoylaconine) after administration of extracts of Aconiti lateralis Radix Praeparata and compatibility with Pinellia, compare the influence of Pinellia on pharmacokinetic characterization of three aconitum alkaloids. Methods: Chromatographic separation were performed on a C18 column under the Pharmacokinetic, Aconiti lateralis Radix, Pinellia, Aconitum alkaloids, UPLC–MS/MS https://www.ijper.org/article/53/2/212-215 2026-04-20T08:57:20.512419+00:00 The Effect of Kahoot Web-Based Learning on Learning Skills of Pharmacy Students: The Trend in Clinical Pharmacokinetics Course for 2 Generations 2019-02-18 10.5530/ijper.53.2.28 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2-212.pdf Background: Kahoot is a web-based learning that uses worldwide in the education field. From the review literature, lecture with a Kahoot web-based learning will improve the learning skill. However, there have been a few studies of using Kahoot web-based learning in pharmacy education. Therefore, the aim of this study is to compare pre-and post -learning skill using Kahoot web-based learning and observe the trend of effect for 2 generations. Method: Pre-and Posttest was established in Clinical Ph Kahoot, Web based learning, Learnings skill, Clinical Pharmacokinetic cause https://www.ijper.org/article/53/2/310-315 2026-04-13T05:55:07.521569+00:00 Method Development and Validation for the Estimation of Dothiepin Hydrochloride by using RP-HPLC in PURE and Tablet Dosage Form 2019-02-18 10.5530/ijper.53.2.39 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2-310.pdf Aim: A simple, sensitive, accurate and precise RP-HPLC method was developed for the determination of Dothiepin HCl (DTH) in pure and tablet dosage form. Methods: The method was developed by using Phenomenex C18 (250 X 4.6 mm, 5 µm) and the mobile phase composed of buffer (0.1M sodium acetate): acetonitrile in the ratio of 50:50 v/v. The buffer pH was adjusted to 2.8. The retention time for Dothiepin HCl was found to be 3.44 min. Linearity range for Dothiepin HCl was found to be 10-60 µg/mL and t Dothiepin HCl, RP-HPLC, Linearity, Dosage form, Precision https://www.ijper.org/article/53/2/250-260 2026-04-13T05:55:07.521569+00:00 Phytochemical Analysis, in vitro Antioxidant Activity and Inhibition of Key Diabetic Enzymes by Selected Nigerian Medicinal Plants with Antidiabetic Potential 2019-02-18 10.5530/ijper.53.2.33 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2-250.pdf Background: Diabetes is one of the most common metabolic disorders worldwide and the disease is generally believed to be incurable. However, the historical success of natural products as therapeutic agents has led to the search for more herbs with antidiabetic potential. Aim: To investigate the antioxidative and antidiabetic activities of some common medicinal plants traditionally used to treat diabetes in Nigeria. Materials and Methods: Twenty one plant samples comprising leaves, seeds and stem Diabetes, Antioxidant, α-amylase, Haemoglobin glycosylation, Natural products https://www.ijper.org/article/53/2/202-207 2026-04-13T05:55:07.521569+00:00 Integration of Pharmacy Education and Pharmacovigilance: Scope and Challenges in India 2019-02-18 10.5530/ijper.53.2.26 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2-202.pdf Aim: Pharmacy Council of India (PCI) and the All India Council for Technical Education (AICTE) are the two professional organizations which are presently regulating the pharmacy education in India. Curriculum change of pharmacy education has been undertaken by central government notification as per amendment of pharmacy act. Methods: All the information and data has been obtained from standard articles, books and official websites including current scenario and topics. Results: Introduction of P Pharmacovigilance, Pharmacy education, Awareness, Students Empowerment, Pharm. D, Career opportunities https://www.ijper.org/article/53/2/325-329 2026-04-13T05:55:07.521569+00:00 Association between Selective Serotonin Reuptake Inhibitors Use and Colorectal Cancer in a CaseControl Study 2019-02-18 10.5530/ijper.53.2.41 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2-325.pdf Objectives: This study’s aim was to investigate whether selective serotonin reuptake inhibitors use was associated with the risk of colorectal cancer. Methods: From the claims data of Taiwan National Health Insurance Program, a retrospective case-control study was conducted to examine 4739 aged 20-84 cases with newly diagnosed colorectal cancer in 2000-2013 and 4739 sex-matched and age-matched controls without colorectal cancer. The prescription history of selective serotonin reuptake inhibitors Case-control study, Colorectal cancer, Selective serotonin reuptake inhibitors, Taiwan National Health Insurance Program https://www.ijper.org/article/53/2/192-201 2026-04-13T05:55:07.521569+00:00 Ethical and Administrative Implications of Nanoscale Technology for Efficient and Safe Delivery of Drugs: Analytical and Regulatory Aspects 2019-02-18 10.5530/ijper.53.2.25 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2-192.pdf Background: Cutting-edge issues for nanomedicine involve knowledge of the problems associated with toxicity and environmental effect of nanoscale substances (substances whose structure is on the dimensions of nanometers, i.e. billionths of a meter). Nanoparticles are able to reach inner biomolecules, which is not possible for larger debris. Materials and Methods: The nanosuspension turned into analytically characterized and subjected to regulatory aspects. Scientific facts used to make regulator Nanosize particles, FDA regulations, Industrial application, Analytical studies, and Nanomaterial safety https://www.ijper.org/article/53/2/301-309 2026-04-13T05:55:07.521569+00:00 Electrospun Silybin Enriched Scaffolds of Polyethylene Oxide as Wound Dressings: Enhanced Wound Closure, Reepithelization in Rat Excisional Wound Model 2019-02-18 10.5530/ijper.53.2.38 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2-301.pdf Aim/ Background: Wounds are considered as a common health problem due to their considerable burden on social life. Polymeric nanofibers have attracted attention in wound dressings due to their large surface area, smaller size and biocompatibility. The objective of this research is to develop silybin loaded polymeric scaffolds and further to check its efficacy in wound healing. Materials and Methods: Silybin loaded polymeric scaffolds was developed using polyethylene oxide as a polymer and glutar Nanofiber, Electrospinning, Scaffold, Silybin, Wound healing https://www.ijper.org/article/53/2/242-249 2026-04-13T05:55:07.521569+00:00 Therapeutic Effect of Nigella sativa Oil in Hepatotoxicity Induced by Isoniazid in Rats 2019-02-18 10.5530/ijper.53.2.32 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2-242.pdf Objectives: Tuberculosis is one the most prevalent microbial diseases worldwide and hepatotoxicity is one of the major side effects of first line anti-tubercular drug, Isoniazid. The reported pharmacological activities of Nigella sativa oil include protection from liver damage caused by diseases, chemicals and chemotherapeutic agents. The aim of the present study was to evaluate therapeutic potential of Nigella sativa oil in hepatotoxicity induced by using Isoniazid. Methods: Isoniazid (50 mg/kg Nigella sativa, Hepatoprotective, Isoniazid, Silymarin, Tuberculosis, Hepatotoxicity https://www.ijper.org/article/53/2/334-342 2026-04-13T05:55:07.521569+00:00 Knowledge and Practices Related to Unused Medications in Households in Serbia 2019-02-18 10.5530/ijper.53.2.43 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2-334.pdf Background: The objective of this study was to examine the knowledge and practices regarding expired medications and to identify their potential predictors. Methods: A cross-sectional study was conducted, between August and November of 2014 in Regional Community Primary Health Care centre in Serbia on 609 patients. The research instrument was the questionnaire. Univariate and multivariate logistic regression analyses were applied. Results: The lack of knowledge about the treatment of expired med Knowledge, Practice, Disposal of medications, Expired medications, inappropriate practice https://www.ijper.org/article/53/2/208-211 2026-04-13T05:55:07.521569+00:00 Collaborative Learning- and Quiz-based Teaching Strategy in Biochemistry and Molecular Biology 2019-02-18 10.5530/ijper.53.2.27 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2-208.pdf Aim: An experimental teaching and learning program used in biochemistry and molecular biology with first-year students in the second term in the Faculty of Biological Sciences at Huanghuai University, China. Materials: Sixty students were divided randomly into two sections (n=30 per section). Students in one section were divided randomly into five groups (six students in each group) and taught using a hybrid collaborative learning and lecture method (experimental section). The second section was Biochemistry and molecular biology, Teaching method, Learning method, Collaborative learning-based lecture, Collaborative quiz-based https://www.ijper.org/article/53/2/276-285 2026-04-13T05:55:07.521569+00:00 Identification of (1E, 3E)-1, 3-bis [(2-hydroxy1-naphthyl) methylene] Urea as Mutated MAP Kinase P38 Inhibitor through Reverse Pharmacophore Mapping Approach: Green Synthesis, Characterisation and in silico Docking analysis 2019-02-18 10.5530/ijper.53.2.36 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2-276.pdf Introduction: Investigations on Schiff bases are one of the current pharmaceutical research trends due to their broad-spectrum biological activities and unique structural features such as intramolecular hydrogen bond formation, unsaturated C-N bond, the high mobility of hydrogen-bonded proton and pseudo aromatic ring formation. Aim: Current work is an attempt to discover the therapeutic potential of such structurally related Schiff bases compounds1-[(E)-[6-[(E)-(2-hydroxy-1-naphthyl) methyleneam Schiff bases, Reverse PharmMapper, Molecular docking, Kinase inhibitor, Dynamics simulation, ADMET Studies https://www.ijper.org/article/53/2/261-267 2026-04-20T09:04:52.117642+00:00 Alcohol Extract of Wattakaka volubilis (L.F) Stapf Root Inhibits Aldose Reductase to Prevent Diabetes Associated Cataract Formation in Rats 2019-02-18 10.5530/ijper.53.2.34 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2-261.pdf Aim: The aim of this study was to investigate the aldose reductase inhibition and anti-cataract property of W. volubilis root extract in rats with streptozotocin induced diabetes mellitus. Methods: Diabetes was induced by a single intraperitoneal injection of streptozotocin at the dose of 45 mg/kg. Diabetic animals were treated with glimepiride (0.5 mg/kg) and alcohol extract at 100 and 200 mg/kg for 38 d. Lens were isolated and certain markers were estimated. Results: Treatment of diabetic anim Wattakaka volubilis, Diabetes mellitus, Cataract, Aldose reductase, Polyol, pathway https://www.ijper.org/article/53/2/330-333 2026-04-13T05:55:07.521569+00:00 Clinical Effects of Pantoprazole and Octreotide in Upper Gastrointestinal Hemorrhage 2019-02-18 10.5530/ijper.53.2.42 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2-330.pdf Objective: This study aimed to discuss the clinical effects of pantoprazole and octreotide in upper gastrointestinal hemorrhage. Methods: A total of 114 patients with upper gastrointestinal hemorrhage admitted in our hospital from April 2016 to June 2017 were chosen and divided into control and experimental groups by lottery method. The control group (n=57) was treated with pantoprazole and the experimental group (n=57) was treated with pantoprazole+ octreotide. The therapeutic effect, occurrenc Octreotide, Pantoprazole, Upper Gastrointestinal hemorrhage https://www.ijper.org/article/53/2/186-191 2026-04-20T08:52:49.350095+00:00 The Role and Suitability of the Objective Structured Practical Examination in Pharmacy Education in Poland 2019-02-18 10.5530/ijper.53.2.24 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2-186.pdf Background: Objective structured practical examination (OSPE) is a new concept that allows students to assess their practical skills. These are multifunctional assessment tools that can be used to test a wide range of students’ competencies. OSPE can be assessed objectively by direct observation supported by a formalized assessment method. Testing of candidates in a wide range of practical and clinical skills is possible thanks to the precision, objectivity and repeatability of examinations. Tra OSPE, Objective structured practical examination, Competencies, Skills, Objectivity, Assessment tool, Pharmacy education https://www.ijper.org/article/53/2/216-224 2026-04-13T05:55:07.521569+00:00 Development and Evaluation of Biodegradable Polymeric Based Long Acting in situ Forming Microparticles of LHRH Agonist Goserelin Acetate 2019-02-18 10.5530/ijper.53.2.29 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2-216.pdf Aim: Goserelin acetate is parenterally administered, a typical LHRH analogue for the treatment of prostate cancer. The objective of present work was to formulate and evaluate long acting in situ forming microparticles of goserelin using PLGA which would extend the drug release. Materials and Methods: PLGA 50:50 were used as the biodegradable polymer, DMSO was as organic solvent and sesame oil was used as dispersion phase. HLB based system was used in present investigation for stabilizing non-aqu Goserelin acetate, In-situ forming microparticles, PLGA, HLB, Burst effect https://www.ijper.org/article/53/2/286-300 2026-04-20T09:06:54.188358+00:00 Ultrasound Assisted Synthesis, Characterization and Antimicrobial Evaluation of Novel OxazolidinoneBiphenyl Chalcone Hybrid Derivatives 2019-02-18 10.5530/ijper.53.2.37 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2-286.pdf Objective: The main objective of our present study, is to potentiate the antibacterial activity of biphenyl chalcones and oxazolidinones, thus in order to achieve the potent antibacterial agents, we coupled both derivatives by using green chemistry approach for Buchwald’s protocol under ultrasound irradiation. Methodology: Ultrasonication technique was used to couple a series of 24 novel bromo-biphenyl-chalcone derivatives and 5-chloromethyl-oxazolidinone in the presence of copper iodide (CuI) ( Buchwald’s Protocol, Ultrasound (US) irradiation, Lithium hydroxide, monohydrate (LiOH.H2O), Aryl aldehydes, Biphenyl chalcones, 5-chloromethyloxazolidinone https://www.ijper.org/article/53/2/225-235 2026-04-13T05:55:07.521569+00:00 Synthesis and Evaluation of Water Insoluble but Swellable Bioadhesive Polymer for Ocular Drug Delivery 2019-02-18 10.5530/ijper.53.2.30 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2-225.pdf Introduction: Our main purpose of present study was to find out the effect of different crosslinking agents along with its concentration during polymer synthesis and to find the most suitable polymer for ocular drug delivery with optimum bioadhesive strength and less irritation potential. It was expected that the synthesized polymer will remain adhered to the conjunctival mucin layer thus preventing loss of drug by precorneal factors. Materials and methods: Acrylic acid procured from Loba chemic Bioadhesion, Ocular, Water Insoluble polymer, Acrylic acid, Hydration https://www.ijper.org/article/53/2/316-324 2026-04-13T05:55:07.521569+00:00 Development and Validation of an HPLC- UV Method for the Determination of Melphalan from Lyophilized Nanosuspension 2019-02-18 10.5530/ijper.53.2.40 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2-316.pdf Aim and Objective: The objective of this work was to develop and validate a high performance liquid chromatography (HPLC) method for the quantitative analysis of melphalan, an anticancer drug from lyophilized nanosuspension. Material and Method: Chromatographic separation was achieved by using a reverse-phase C18 column (150 mm ×4.6 mm, pore size 5 μm, Phenomenex). The mobile phase was optimized as acetic acid, water and methanol (1: 49.5: 49.5) with pH 4 at a flow rate of 1 mL/min. The melphala Melphalan, HPLC, Lyophilized nanosuspension, Entrapment Efficiency, Precision, Accuracy https://www.ijper.org/article/53/2/268-275 2026-04-20T09:05:32.163546+00:00 SAR Evaluation of Disubstituted Tacrine Analogues as Promising Cholinesterase and Carbonic Anhydrase Inhibitors 2019-02-18 10.5530/ijper.53.2.35 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-2-268.pdf Background: The inhibition of both hydrolysis products of acetylcholine (ACh), Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE), is essential for successful treatment of Alzhemier patients. Objectives: This study was investigated inhibition potentials of recently synthesized disubstituted tacrines derivatives on going our research against AChE, BChE and carbonic anhydrase cyctosolic (hCA I and II) enzymes to explore the Structure activity relationship (SAR). Methods: Inhibitory activ Tacrine derivatives, Acetylcholinesterase, Butyrylcholinesterase, Carbonic, anhydrase, Anticholinegic, SAR https://www.ijper.org/article/53/1/133-143 2026-04-20T08:45:39.698681+00:00 Development and Validation of an Environmentally Benign and Robust Stability Indicating Assay Method for Lenalidomide: Comprehensive Degradation Kinetics Study and Application of Synergistic Approach Involving Green Analytical Chemistry and Quality by Design Methodology 2019-01-07 10.5530/ijper.53.1.18 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-133.pdf Objective: A state of the art, robust and environmentally benign stability indicating assay method (SIAM) has been developed for model drug Lenalidomide (LEN). Methods: A Green metrics assessment was conducted by environment assessment tool (EAT), analytical method volume intensity (AMVI) and Ecosolvent® tool. Successful chromatographic separation was accomplished on a Thermo C18 GAC column having dimensions of 4.6×150 mm and 3μ particle size using green solvents viz., methanol and acetate buffe Lenalidomide, Green analytical chemistry, Quality by Design, Degradation, kinetics, LC-MS/MS https://www.ijper.org/article/53/1/28-41 2026-04-13T05:55:09.324349+00:00 Implementation of Innovative Learning Material to Improve Students Competence on Chemistry 2019-01-07 10.5530/ijper.53.1.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-28.pdf Background: Improving students competence to provide appropriate knowledge and skills to deal with professional works becomes a challange in education nowdays. Objectives: This research is aimed to develop and implement an inovative learning material to be used as learning media in the teaching and learning activities to improve students’ competence on chemistry. Materials and Methods: The procedures consist of the development and standardization of an innovative learning material with tasks ins Innovative learning material, Multitasks instruction, General Chemistry, Stoichiometry topics, Active learning https://www.ijper.org/article/53/1/171-177 2026-04-20T08:49:17.268241+00:00 Release of Doxorubicin’s Active Ingredient from the Hydrogels Derived from Acrylamide and their Biological Functions 2019-01-07 10.5530/ijper.53.1.22 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-171.pdf Poly (HEMA/acrylamide/ methyl methacrylate) (PHAM) and Poly (Acrylamide/ methyl methacrylate)(PAM) polymers were synthesized for using in the release of Doxorubicin drug. Poly (HEMA/acrylamide/methyl methacrylate) (PHAM) and Poly (Acrylamide/methyl methacrylate) (PAM) composite hydrogels were prepared by a radical addition reaction in aqueous media formed by HEMA, acrylamide, and methacrylamide, with the presence of N,N’-methylenebisacrylamide. The characterization of the polymer was performed b Doxorubicin, Poly(HEMA/acrylamide/methyl methacrylate), Poly(Acrylamide/, methyl methacrylate), Drug release https://www.ijper.org/article/53/1/160-170 2026-04-20T08:48:19.906533+00:00 Phenolic Contents and Biological Activity of Endemic Origanum minutiflorum Grown in Turkey 2019-01-07 10.5530/ijper.53.1.21 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-160.pdf Objective: In this study, biological property of Origanum minutiflorum O. Schwarz and P. H. Davis (Lamiaceae) was evaluated. Methods: The total phenolic and flavonoid amount were detected using Folin-Ciocalteu and aluminum chloride colorimetric assays. The antioxidant activity was assayed with phosphomolybdenum, 2,2- diphenyl-1- picrylhydrazyl radical scavenging (DPPH), hydrogen peroxide scavenging, β-carotene bleaching activity, ferric-ion reducing power (FRAP), reducing power and cupric ions ( Antimicrobial activity, Cuprac, Essential oil, Frap, Origanum minutiflorum https://www.ijper.org/article/53/1/144-150 2026-04-20T08:46:11.586351+00:00 Fatty Acid Composition, Total Phenolic Content and Antioxidant Activity of Grape Seed Oils Obtained by Cold- Pressed and Solvent Extraction 2019-01-07 10.5530/ijper.53.1.19 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-144.pdf Aim: The aim of this study was to determine the influence of two different extraction methods on the fatty acid composition, total phenolic content and antioxidant activity of grape seed oils obtained from 5 different varieties. Materials and Methods: The seeds of the Syrah, Merlot, Sangiovese, Cabernet Sauvignon, Sauvignon Blanc grape varieties were used in this study. Oil extraction was carried out by Soxhlet extraction and coldpressed extraction methods. Results: The most abundant fatty acids Grape seed oil, Fatty acid composition, Phenolic content, Antioxidant, activity, Extraction method https://www.ijper.org/article/53/1/8-20 2026-04-13T05:55:09.324349+00:00 Chemistry and Pharmacology of Flavonoids- A Review 2019-01-07 10.5530/ijper.53.1.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-8.pdf Several modern and most of the traditional drugs have been developed from natural sources. Flavonoids or bioflavonoids, most ubiquitous polyphenolic compounds, are secondary metabolites of plants and fungal origin. Apart from their biological functions in plants (protection against herbivores, ultraviolet radiation and pathogens), they perform myriads of pharmacological activities in humans as well. Though flavonoids are not acknowledged as nutrients still their intake on regular basis is consid Flavonoids, Polyphenolic compound, Pharmacological activity, Mechanism, Biosynthesis https://www.ijper.org/article/53/1/112-116 2026-04-13T05:55:09.324349+00:00 Anthocyanins from Black Chokeberry Delayed Ageing-related Degenerative Changes in the Heart 2019-01-07 10.5530/ijper.53.1.15 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-112.pdf Aim: Aging is the greatest risk factor for most neurodegenerative diseases. Cardiovascular circulatory system is an important part of maintaining normal human life activities. The core of the aging process is DNA damage, a food additive called Anthocyanin which has shown high efficacy in preventing aging, We examine whether anthocyanins could keep young mice from accelerated ageing of the heart. Materials and Methods: In order to accelerate ageing, Mice of Kunming were injected with D-galactose Anthocyanins, Aornia mealnocarpa, Aged, DNA damage, Molecular docking https://www.ijper.org/article/53/1/127-132 2026-04-20T08:44:46.451989+00:00 Effects of Alprazolam Administration on the Vital Organs of Adult Wister Albino Rats, Biochemical and Toxicological Studies 2019-01-07 10.5530/ijper.53.1.17 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-127.pdf Objective: Effect of Benzodiazepine group of drugs Alprazolam is investigated on different vital organs of Wister albino rat. Materials and Methods: The rats (n=6) were treated with normal doses of Alprazolam for two months along with a placebo group (n=6). After the treatment blood samples were collected and then the rats were sacrificed to collect the tissues of heart, liver and kidney. Results: The levels of enzymes ALT/SGPT, AST/SGOT and the signaling molecule NO were estimated. It was seen Alprazolam (Alp), Cell death, Necrosis, Biochemical enzymes, Nitric Oxide (NO) https://www.ijper.org/article/53/1/151-159 2026-04-20T08:46:52.181899+00:00 Antidiabetic Activity of Isolated Compound from Coccinia indica 2019-01-07 10.5530/ijper.53.1.20 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-151.pdf Background and Objective: Coccinia indica Wight. and Arn (Ivy gourd, family Cucurbitaceae) has a long tradition of use in the treatment of various ailments. Ayurveda and Unani systems claim C. indica as antidiabetic agent. Therefore the present investigation was aimed to evaluate antidiabetic activity of isolated compound(s) from C. indica. Materials and Methods: Methanol extract of C. indica aerial parts was prepared by Soxhlet extraction method and ethyl acetate fraction was prepared by partit Antidiabetic, Coccinia indica, Cucurbitaceae, Quercetin, Streptozotocin https://www.ijper.org/article/53/1/178-185 2026-04-13T05:55:09.324349+00:00 A Critical and Comparative Study on Patient Information Leaflet, Primary Label and Primary Carton of a Carbapenem Dry Powder Injectable 2019-01-07 10.5530/ijper.53.1.23 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-178.pdf Introduction: The main aim of this project was to study the patient information leaflets (PIL), primary labels (PL) and primary cartons for their adequacy, harmonization of printed text matter meeting regulatory requirements. Methods: The study involved comparative evaluation of PIL, PL and primary cartons of generic and innovator brands. Three different marketed brands of Meropenem for Injection IP were considered for this research study which include the innovator product, coded as brand A and Patient information leaflet, Primary label, Primary carton, Text matter, Harmonization https://www.ijper.org/article/53/1/42-47 2026-04-13T05:55:09.324349+00:00 Assessment of Views Opinions and Perceptions of Pharmacy Students towards Doctor of Pharmacy Profession in India 2019-01-07 10.5530/ijper.53.1.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-42.pdf Background: Although clinical pharmacy is considered as one of the most vibrant and exigent professions, when it comes to the recognition, scope and the career opportunities for Pharm D professionals are ill-defined in the current scenario of Indian Pharmacy. The SPICE-PHARM study (Suggestions, Perceptions and Ideas for Comprehensive Education system towards Pharmacy profession) primarily aims at the various views, opinions and perceptions of Pharm D students in order to enhance the standards wi Doctor of Pharmacy, Pharm D Profession in India, Pharmacy students, Clinical, Pharmacy, Cross sectional study, Questionnaire-based survey https://www.ijper.org/amelioration-of-metabolic-syndrome-in-high-fat-fed-mice-by-hydro-ethanolic-fract 2026-04-20T08:43:05.959836+00:00 Amelioration of Metabolic Syndrome in High Fat Fed Mice by Hydro-ethanolic Fraction of M. longifolia (J. Koenig) 2019-01-07 10.5530/ijper.53.1.14 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-104.pdf Objective: To investigate the effect of hydro-ethanolic fraction of leaves of M. longifolia (J. Koenig) on high fat diet induced metabolic disorder. Methods: The M. longifolia extract was obtained from the successive extraction followed by fractionation. Ex vivo glucose uptake study was performed. Body weight and blood glucose was checked at regular intervals. After euthanasia serum biochemical parameters, lipid parameters were estimated. Organs were isolated, weighed and fixed in formalin for h M. longifolia, Ex vivo, Metabolic disorder, In vivo, Blood glucose, BMI https://www.ijper.org/challenges-in-simultaneous-analysis-of-hydrolytically-sensitive-ester-drugs-in-c 2026-04-13T05:55:09.324349+00:00 Challenges in Simultaneous Analysis of Hydrolytically Sensitive Ester Drugs in Combined Dosage Forms 2019-01-07 10.5530/ijper.53.1.13 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-97.pdf Objective: Two or more ester drugs in multicomponent formulations are likely to exhibit errors during analysis under acidic conditions, possibly due to hydrolysis. UV Spectrometric methods are hard to disseminate such phenomenon while HPLC methods could provide an insight into possible degradations as source for erroneous conclusions. Material and Methods: Combined dosage formulation of aspirin and clopidogrel bisulphate has been used in the study to demonstrate limitations of popular Absorbance Absorbance Ratio, HPLC, Aspirin, Clopidogrel, Hydrolysis, Degradation https://www.ijper.org/article/53/1/117-126 2026-04-20T08:44:12.080704+00:00 Synthesis and Evaluation of New Brominated Azaflavones and Azaflavanone Derivatives as Cytotoxic agents against Breast Cancer Cell Line (MCF-7) 2019-01-07 10.5530/ijper.53.1.16 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-117.pdf Background: Flavonoids encompasses flavones, isoflavones, flavanones and flavanols each possessing the benzopyranone ring system as the common structural feature, were identified as potent nonsteroidal aromatase inhibitors (NSAIs). Purpose: Azaflavones which were isosteric structural scaffolds of flavonoids were also proven to be potent NSAIs. In order to develop new NSAIs as cytotoxic agents for breast cancer, we designed some 6-bromo-2-substituted azaflavanones and azaflavone derivatives. Meth Azaflavones, Azaflavanones, Claisen-Schmidt condensation, Cytotoxicity, MTT assay, FT-IR, NMR https://www.ijper.org/how-pharmacy-students-evaluate-the-credibility-of-scientific-information-a-quali 2026-04-13T05:55:09.324349+00:00 How Pharmacy Students Evaluate the Credibility of Scientific Information: A Qualitative Study 2019-01-07 10.5530/ijper.53.1.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-79.pdf Objective: This research is aimed at exploring the evaluation of information credibility and its related criteria from the viewpoints and experiences of PhD students in pharmacy in Tabriz University of Medical Sciences, Iran. Methods: The qualitative data were collected through semi-structured interviews. Using convenience sampling method, 13 PhD students in pharmacy were selected. Rigor of the study was approved by member checking and external audit. A content analysis approach (inductive and d Information Credibility, Evaluation Criteria, Source Selection Criteria, Use of, Information, Pharmacy Students https://www.ijper.org/establishing-and-evaluating-clinical-pharmacy-training-program-in-china-pharmace 2026-04-20T08:40:44.129858+00:00 Establishing and Evaluating Clinical Pharmacy Training Program in China Pharmaceutical University 2019-01-07 10.5530/ijper.53.1.10 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-70.pdf Background: Clinical pharmacy training is to help students master the skills of clinical pharmacy services and increase students’ confidence in their ability to perform clinical roles effectively. Objective: This study aimed to introduce and evaluate clinical pharmacy training program in China Pharmaceutical University for bachelor’s degree students majored in clinical pharmacy. Method: Clinical pharmacy training in China Pharmaceutical University comprises various modules. In this article we ha Clinical pharmacy training, Evaluation, Clinical pharmacy students, China, Pharmaceutical University https://www.ijper.org/formulation-and-evaluation-of-chitosan-based-transdermal-patches-of-lornoxicam-f 2026-04-13T05:55:09.324349+00:00 Formulation and Evaluation of Chitosan Based Transdermal Patches of Lornoxicam for Prolonged Drug Release and to Study the Effect of Permeation Enhancer 2019-01-07 10.5530/ijper.53.1.12 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-88.pdf Objective: The objectives of present investigation were to develop transdermal system for Lornoxicam using chitosan as rate controlling polymer and Tween 20 as permeation enhancer. Then evaluate the effect of Tween 20 on the physico-chemical properties of the patches and on drug permeation across the membrane. Methods: Transdermal patches of Lornoxicam were prepared by solvent casting method. The prepared patches were evaluated for physicochemical characteristics such as in vitro drug release, s Transdermal patches, Chitosan, Lornoxicam, Tween 20, in-vitro release, studies https://www.ijper.org/article/53/1/54-60 2026-04-20T08:39:26.981801+00:00 The Community Pharmacist Caught between Ethics, Pharmacy Management and Patient needs Assessment of the Main Stress Factors for the Pharmacists in the Community Pharmacy in Romania 2019-01-07 10.5530/ijper.53.1.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-54.pdf Objectives: This study aims to evaluate the main stress factors for the pharmacist in the community pharmacy in Romania and how the pharmacists manage the tensions generated by professional ethics, patient attitudes and pharmacy management, and the degree of professional satisfaction of pharmacists. Materials and Methods: The study was conducted over 7 months. The population surveyed consisted of 376 pharmacists working in the community pharmacy. They completed a questionnaire consisting of six Community pharmacists, Stress factors, Pharmacy management, Current, pharmaceutical market, Ethics https://www.ijper.org/developing-a-learner-centered-pharmaceutical-care-course-using-a-focus-group-app 2026-04-20T08:40:07.485494+00:00 Developing a Learner-Centered Pharmaceutical Care Course using a Focus Group Approach 2019-01-07 10.5530/ijper.53.1.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-61.pdf Background: the aim of this article was to obtain the opinions of a pharmacist teachers group regarding the pharmaceutical care course model most suited to Brazil. Methods: five teachers of pharmaceutical care courses in public Faculty of Pharmacy in Brazil were selected to participate. Participants were asked to provide their perceptions about 3 predetermined questions regarding the content that should be taught in pharmaceutical care course, skills that should be taught in the course, and lear Dontent analysis, Developing countries, Focus groups, knowledge, construction, Teaching / learning strategies https://www.ijper.org/article/53/1/48-53 2026-04-20T08:38:05.821699+00:00 Perception towards the Standardization of Competency Assessment Tools among Clinical Pharmacists in the Philippines 2019-01-07 10.5530/ijper.53.1.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-48.pdf Background: Clinical Pharmacists are dependent on assessment tools to evaluate the competency skills of student interns. Aim: This study aims to examine the perception of Clinical Pharmacists towards the standardization of competency assessment tools in the Philippines. Methods and Material: A descriptive cross-sectional study was conducted among 115 clinical pharmacists from 5 urban areas using a 20-item selfadministered questionnaire through online survey. Results: Results showed that 25% of t Competency assessment, Clinical pharmacy education, Perception, Standardization, Philippines https://www.ijper.org/article/53/1/21-27 2026-04-20T08:35:49.533136+00:00 Effect of Strategic Marketing on Sustainable Business Performance–A Study of Pharmaceutical Industries in India 2019-01-07 10.5530/ijper.53.1.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-21.pdf Background: Concern over sustainability awakened firms to take responsive strategies and propagate sustainability. The present study tries to enumerate the role of strategic marketing orientation classified as market-orientation and innovation orientation on sustainability in business performance. Materials and Methods: Data was collected using structured questionnaires. The empirical model was tested using structural equation modeling. Results and Conclusion: The results suggest that innovation Sustainability in performance, Strategic market orientation, Strategic, innovation orientation, Environmental downturn, Economic performance https://www.ijper.org/article/53/1/5-7 2026-04-20T08:35:00.079149+00:00 Excipients: The Real Players behind Robust Formulation 2019-01-07 10.5530/ijper.53.1.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-5.pdf The backbone of any successful robust pharmaceutical product is built on their excipients. Excipients show a vital role in the dosage form design. Excipients do not have therapeutic activity, however, they influence the therapeutic activity of active pharmaceutical ingredient (API) through formulation characteristics. Please note inactive ingredients are clearly not reliably inert in their biological activity and thus should not be listed as such. A more suitable and concise term is excipient. Review Article https://www.ijper.org/article/53/1/1-4 2026-04-20T08:33:38.646015+00:00 Professor Harkishan Singh- A Man with a Mission 2019-01-07 10.5530/ijper.53.1.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-53-1-1.pdf In 1967-68 I was studying in the final year (1967-68) of the B. Pharmacy course in the Government College of Pharmacy, Bangalore (now Bengaluru) in Karnataka. There was so much of halla gulla about Medicinal Chemistry practical examination that our teacher told us read Morrison and Boyd’s Organic Chemistry book. We had only one copy of the book in the library and we used to get it issued turn by turn for overnight home reading. There was a sigh of relief on the day of the examination when we cam Tribute https://www.ijper.org/article/52/4s2/s220-s228 2026-04-20T07:42:01.841403+00:00 Development and Evaluation of Nevirapine Extended Release Tablets using QbD Approach 2018-11-28 10.5530/ijper.52.4s.101 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s2-220.pdf Objective: To develop and evaluate Nevirapine (NVP) Extended release tablets for reducing the dosing frequency using Methylcellulose USP Methocel A15-LV and Hypromellose USP Methocel K4M Premium CR used as rate retarding polymers and Magnesium stearate as lubricant. Methods: Tablets were prepared by using roller compaction technique by employing Quality by Design (QbD) and Design of Experimentation (DoE) to study the effect of various process related parameters like Bulk density, Tapped density, Quality by design, Nevirapine, Design of experimentation, Extended release, HIV/AIDS, Tablets https://www.ijper.org/article/52/4s2/s237-s245 2026-04-20T07:41:54.995588+00:00 Evaluation of Comparative Immunomodulatory Potential of Solanum xanthocarpum Root and Fruits on Experimental Animal 2018-11-28 10.5530/ijper.52.4s.103 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s2-237.pdf Aim: This study was aimed to justify the scientific basis in folklore use of Solanum xanthocarpum (solanaceae) as an Immunomodulatory agent in India. Materials and Methods: The ethanol and aqueous extracts of S. xanthocarpum fruit (SXE-1 and SXA-1), root (SXE-2 and SXA-2) and whole plant (SXE-3 and SXA-3) were evaluated for immunomodulatory activity by using cold water swim endurance stress test, delayed type hyper sensitivity reaction, carbon clearance test and CCl4 induced oxidative stress mod S. xanthocarpum, Solasodaine, HPLC, Immunomodulatory, CCl4 https://www.ijper.org/article/52/4s2/s174-s183 2026-04-20T07:42:19.166686+00:00 Preparation and Characterization of Silymarin Nanocrystals and Phytosomes with Investigation of their Stability using Gamma Irradiation 2018-11-28 10.5530/ijper.52.4s.96 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s2-174.pdf Introduction: In this study, Silymarin exhibits poor water solubility so, we developed drug delivery system. Different formulation strategies have been proposed for this problem. Materials and Methods: We were study the preparation of silymarin by dissolving it in different solvent (acetone,acetonitrile ,ethanol and methanol) to form nanocrystal and combination between lecithin and silymarin to prepare phytosome. And determined physicochemical characterization including dissolution, drug content Silymarin, Nanocrystals, Phytosomes, Gamma irradiation, in-vitro dissolution https://www.ijper.org/article/52/4s2/s257-s267 2026-04-20T07:41:43.626959+00:00 Agreement between Creatinine and Cystatin C-Based Equations in the Estimation of Glomerular Filtration Rate among Malaysian Patients with Renal Impairment 2018-11-28 10.5530/ijper.52.4s.106 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s2-257.pdf Background: Cystatin C-based equations have been proposed as an alternative for creatinine-based equations in the estimation of Glomerular Filtration Rate (eGFR). Limited studies were available with regards to the Asian population to evaluate the agreement of eGFR measured based on both biomarkers. This study aimed to evaluate the agreement between various cystatin C- and creatinine-based eGFR equations. Methods: Patients were recruited from the Nephrology Clinic Universiti Kebangsaan Malaysia M Cystatin C, Creatinine, Estimated Glomerular Filtration Rate, Renal Function, Renal Elimination, Chronic Kidney Disease https://www.ijper.org/article/52/4s2/s303-s308 2026-04-20T07:41:26.55503+00:00 Development of Novel Dynamic Drop-to-Drop Microextraction Coupled with GC-MS for the Trace Level Screening of Phenothiazine Drug in Human Biological Samples 2018-11-28 10.5530/ijper.52.4s.111 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s2-303.pdf A novel analytical technique of dynamic drop-to-drop solvent microextraction (DDSME) is developed to determine phenothiazine drug promethazine commonly used in cough syrups and in aesthetic drinks, purple drank most common among youths. Here we apply coupling of highly sensitive technique of GC-MS with dynamic DDSME for the subnanomolar detection of promethazine drug from human biological samples (blood and urine). The method is a virtually solvent free and miniaturized version of traditional Li Dynamic DDSME, Mass-spectrometry, Pharmacokinetic studies, Promethazine, Optimization https://www.ijper.org/article/52/4s2/s202-s209 2026-04-20T07:42:08.830666+00:00 Chitosan Loaded Ketorolac Tromethamine Nanoparticles for Improved Ocular Delivery in Eye Inflammation 2018-11-28 10.5530/ijper.52.4s.99 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s2-202.pdf Aim: Ketorolac tromethamine (KT) is highly effective in treating post-operative eye inflammation, allergic conjunctivitis as well other ailments. It is reported that USFDA has approved a 0.45% ophthalmic solution of KT (Acuvail, Allergan, Inc) for the treatment of pain and inflammation after cataract surgery. However, the bioavailable amount of an ocular dosage form is very low due to continuous defensive mechanism in the eye. Thus the aim of present study was to improve the bioavailability of K Ketorolac tromethamine, Chitosan, Tripolyphosphate, Nanoparticles, Design, expert https://www.ijper.org/article/52/4s2/s164-s173 2026-04-20T07:42:22.315724+00:00 Community Pharmacists’ Perceptions and Experiences towards Values, Ethics and Decisionmaking: A Qualitative Study 2018-11-28 10.5530/ijper.52.4s.95 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s2-164.pdf Background: In Community Pharmacy, prescriptions, medical devices and other over the counter products are dispended by community pharmacists. Ethical issues do exist while dispensing medications based on prescription and over the counter products. Objective: A qualitative study was conducted on community pharmacists to get their perceptions and experiences towards values, ethics and decision-making. Methods: Data were collected from the qualified community pharmacists through the focused group d Community Pharmacy, Ethic, Decision-making, India, Pharmacy value https://www.ijper.org/article/52/4s2/s287-s295 2026-04-20T07:41:33.266453+00:00 A LC/MS-MS Guided Isolation of Laccaic Acid-A: A Potent Antimicrobial Agent 2018-11-28 10.5530/ijper.52.4s.109 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s2-287.pdf Background: Lac is traditionally used as a dye because of its coloring properties and it is obtained from Laccifer lacca Kerr. Now a days, it is widely used in food and coloring industry. Purpose: To evaluate the antioxidant, antimicrobial activity of different extracts along with identification of active constituents present in it. Methods: Antioxidant activity was performed by DPPH, reducing power and hydrogen peroxide scavenging activity, whereas antimicrobial activity was performed by well d Laccifer lacca Kerr, DPPH, Reducing power, Hydrogen peroxide, Antimicrobial, assay, LC-MS/MS, Laccaic acid-A https://www.ijper.org/article/52/4s2/s333-s342 2026-04-20T07:41:08.575088+00:00 Design, Synthesis, Antioxidant and Anticancer Activity of Novel Schiff’s Bases of 2-Amino Benzothiazole 2018-11-28 10.5530/ijper.52.4s.114 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s2-333.pdf Introduction: Around 5,00,000 women are affected by cervical cancer and nearly half of them end up losing the battle of life with this deadly disease. So, there is an urgent need for the synthesis and development of new, small, synthetic molecules to tackle this challenge. Schiff’s bases are derivatives of azomethine group (-CH=N-) and are highly reactive. Here a series of novel Schiff’s bases were synthesized by single step process of condensing substituted 2-amino benzothiazole with different Schiff’s base, Anti-cancer activity, HeLa, 1RE1, 1RHM, 3DEH, Antioxidant, activity https://www.ijper.org/article/52/4s2/s184-s196 2026-04-20T07:42:15.288126+00:00 Insertion of Dual Drugs of Hypertension in Gelatin Pockets for Chrono pharmacotherapy and its Evaluation by in-vitro and ex- vivo Studies 2018-11-28 10.5530/ijper.52.4s.97 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s2-184.pdf Objective: The project was aimed to fabricate and evaluate a pulsatile capsule to program the release of dual antihypertensive drugs to mimic the circadian pattern of Blood Pressure. The formulation was optimized to repeatedly release the drug in pulses during the vulnerable period of 4 a.m. to noon upon administration during bed time. Methods: Formulation was prepared by means of Pulsincap technology. It consisted of an insoluble capsule body housing a layer of swellable polymer, a Losartan tab Pulsatile capsule, Erodible polymer tablet, Hypertension, Swellable polymer, Losartan Potassium, Amlodipine besylate https://www.ijper.org/article/52/4s2/s277-s286 2026-04-20T07:41:36.090592+00:00 Development and Validation of a LC-ESI-MS/MS Based Bioanalytical Method for Dapagliflozin and Saxagliptin in Human Plasma 2018-11-28 10.5530/ijper.52.4s.108 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s2-277.pdf Objective: To develop a new, rapid and sensitive LC-ESI –MS/MS method for the simultaneous estimation of Dapagliflozin and saxagliptin in human K2EDTA plasma by Liquid –liquid Extraction method (LLE) using deutereated dapagliflozin (DGd2) and saxagliptin (SGd5). Method: Chromatographic separation was carried out on a reverse phase hypersil Gold C 18 (50mmx3.0mm, 5µm) column using mixture of 10 mM Ammonium acetate and methanol (20:80, v/v) at a flow rate of 0.5ml/min in isocratic mode. Quantifica Application to pk profile studies, Method development, Validation, Dapagliflozin, Saxagliptin, LC-ESI-MS/MS https://www.ijper.org/article/52/4s2/s246-s251 2026-04-20T07:41:50.964264+00:00 Chorioallantoic Membrane (CAM) Assay of Different Extracts of Rhizome and Inflorescence of Heliconia rostrata 2018-11-28 10.5530/ijper.52.4s.104 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s2-246.pdf Background: Rhizomes of Heliconia rostrata (Heliconiaceae) has antiophidic, in vitro antioxidant and antibacterial activity. Aim: Extracts of rhizome and inflorescence of H. rostrata were studied to test their angiogenesis and anti-angiogenesis effect using ex-ovo chorioallantoic membrane (CAM) assay. Methods: Dried defatted rhizomes of H. rostrata were macerated using ethanol, methanol and water to obtain rhizome ethanol extract (REE), rhizome methanol extract (RME) and rhizome aqueous extract Rhizome, Inflorescence, Chorioallantoic, Angiogenesis, Anti-angiogenesis https://www.ijper.org/article/52/4s2/s210-s219 2026-04-20T07:42:05.755116+00:00 Formulation of Dispersed Gliclazide Powder in Polyethylene Glycol–Polyvinyl Caprolactam– Polyvinyl Acetate Grafted Copolymer Carrier for Capsulation and Improved Dissolution 2018-11-28 10.5530/ijper.52.4s.100 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s2-210.pdf Background: Oral bioavailability of gliclazide, a hypoglycemic drug, is hindered by its low aqueous solubility. Improvement of solubility will enhance dissolution rate and in turn the bioavailability. This research aimed to formulate the solid dispersed gliclazide using a novel polyethylene glycol–polyvinyl caprolactam–polyvinyl acetate grafted copolymer (Soluplus®) as carrier to enhance in-vitro dissolution and to study drug-carrier physical interaction. Method: Final solid dispersion (SDGLC) c Solid dispersion, Gliclazide, Soluplus®, Improved dissolution, Amorphous https://www.ijper.org/article/52/4s2/s309-s325 2026-04-20T07:41:20.355525+00:00 Quinazoline Derivatives as Anticancer Agents: QSAR, Molecular Docking and in silico Pharmacokinetic Prediction 2018-11-28 10.5530/ijper.52.4s.112 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s2-309.pdf Context: Molecular target specific treatment for the cancer is different from the conventional chemotherapy and radiotherapy in terms of selectivity and specificity towards the cancer cells. Amongst the different molecular targets for cancer, EGFR tyrosine kinase is considered more promising molecular target for discovery and development of the novel anticancer agents. EGFR overexpression and deregulation or mutation are observed in the different kinds of epithelial cancer namely non-small-cell ErbB, EGFR, 3D-QSAR, Contour maps, Molecular docking, ADMET https://www.ijper.org/article/52/4s2/s155-s157 2026-04-20T07:42:28.307647+00:00 Potential Antithrombotic Effect of Crataegus Species 2018-11-28 10.5530/ijper.52.4s.93 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s2-155.pdf Hawthorn (Crataegus), a highly important medicinal and aromatic plant, has been used for many years in the treatment of various diseases. In folk medicine, hawthorn has been used to treat asthma, hyperlipidemia, heart failure, and pain. Today, one of the predominant uses of hawthorn extract is to combat Cardiovascular diseases (CVDs), such as angina, hypertension, arrhythmias, and congestive heart failure. Crataegus species contain flavonoids, proanthocyanidins, organic acids and certain amines. Review Article https://www.ijper.org/article/52/4s2/s229-s236 2026-04-20T07:41:58.67069+00:00 Impact of Surfactants on Formulation Parameters and in vitro Cytotoxicity of Boswellic Acids Loaded Nanoparticles on Human Colon Cancer Cell Lines 2018-11-28 10.5530/ijper.52.4s.102 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s2-229.pdf Objective: Boswellic acids extracted from the gum resin of plant Boswellia serrata are well reported for anti-inflammatory and anticancer activities. The Present investigation was aimed to optimize the surfactant concentration by formulating a series of Boswellic acids nanoparticles. Methods: Nanoparticles were prepared by nanoprecipitation technique using diverse ratios of non-ionic surfactants (Polyvinyl alcohol and Pluronic F-127). Effect of surfactant concentration was studied on size, polyd Boswellic acids, Nano precipitation, Surface morphology, MTT assay https://www.ijper.org/article/52/4s2/s268-s276 2026-04-20T07:41:39.049562+00:00 Novel Quinolone Substituted Quinazolin-4(3H)-Ones as Anti-Inflammatory, Anticancer Agents: Synthesis and Biological Screening 2018-11-28 10.5530/ijper.52.4s.107 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s2-268.pdf Background: Quinolones and, quinazolinones are important pharmacodynamic heterocyclic nuclei which when incorporated into different heterocyclic templates, have been reported to possess potent anti-inflammatory and anticancer properties. The activity of these compounds were associated with inhibition of nuclear factorkappaB (NF-κB) which is one of the important targets studied for designing of antiinflammatory and antitumor drug. Further, the combination of two pharmacophores on the same molecul Anti-inflammatory, Anticancer, Docking, Quinolone, Quinazolinone, NF-κB https://www.ijper.org/article/52/4s2/s252-s256 2026-04-20T07:41:47.3387+00:00 Phytotoxic, Cytotoxic and Insecticidal Activities of Chrysophthalmum dichotomum Boiss. and Heldr. 2018-11-28 10.5530/ijper.52.4s.105 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s2-252.pdf Background: Chrysophthalmum dichotomum Boiss. and Heldr. (Asteraceae) is an endemic herbaceous plant to Southern part of Turkey. Aim: To investigate in vitro phytotoxic, cytotoxic and insecticidal activities of C. dichotomum. Methods: The MeOH extract of C. dichotomum was fractionated through subsequent solvent extractions in increasing polarity with n-hexane, chloroform and n-butanol. The MeOH extract and its fractions were evaluated for their biological acitivities using in vitro screening bio Chrysophthalmum dichotomum, Asteraceae, Phytotoxicity against Lemna, minor, Cytotoxicity on brine shrimps, Insecticidal activity https://www.ijper.org/article/52/4s2/s326-s332 2026-04-20T07:41:12.968647+00:00 Evaluation of Neuroprotective Potential of Some Newly Synthesized Benzopyran-2-One Derivatives in Swiss Albino Mice 2018-11-28 10.5530/ijper.52.4s.113 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s2-326.pdf Background: Present study was carried out to evaluate neuroprotective activity of newly synthesized Benzopyran-2-one derivatives. Methods: Three compounds namely 7-(2-(o-furan)-phenyl thiazolidinyl)-4-methyl benzopyran-2-one (FPTMB), 7-(2-(N,N dimethyl)-phenyl thiazolidinyl)-4-methyl-benzopyran-2-one (DPTMB) and 7-(2-(p-hydroxy)- phenyl thiazolidinyl)-4-methyl-benzopyran-2-one (HPTMB) were assessed for their effects on Central Nervous System (CNS) using a series of established pharmacological te Benzopyran-2-one derivatives, Actophotometer, Eddy’s hot plate, Evasion, test, Epilepsy https://www.ijper.org/article/52/4s2/s296-s302 2026-04-20T07:41:29.874158+00:00 Pharmacophore and Atom Based 3D QSAR Studies on the Novel 5-Alpha-Reductase Inhibitors 2018-11-28 10.5530/ijper.52.4s.110 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s2-296.pdf Aim/Background: The anomalous production of dihydrotestosterone (DHT) observed in benign prostatic hyperplasia and prostate cancer particularly in tissues of the prostate gland. The primary male sex hormone, testosterone (T) is improved to a metabolite in cells by 5a-reductase (5aR) type II enzyme through NADPH. A metabolite is DHT which is more potent than T. Drug therapy is the best alternative for the treatment of benign prostatic hyperplasia (BPH). Drug therapy act by dropping the DHT format 5-alpha reductase, Pharmacophore, QSAR, DHT, BPH https://www.ijper.org/article/52/4s2/s197-s201 2026-04-20T07:42:12.13019+00:00 Development of Ketoconazole Shampoo with Dipterocarpus alatus Oil as a Permeation Enhancer 2018-11-28 10.5530/ijper.52.4s.98 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s2-197.pdf Purpose: To develop and evaluate a model ketoconazole shampoo that includes Dipterocarpus alatus oil as a natural permeation enhancer. Methods: Model shampoos containing ketoconazole, D. alatus oil (1-3% v/v), sodium lauryl ether sulfate, sodium lauryl sulfate, lanolin, cocamidopropyl betaine and fragrance were formulated and evaluated for pH, viscosity and appearance. Ketoconazole content was determined by UV spectrophotometry for preliminary stability testing, drug release and permeation studi Dipterocarpus alatus, Shampoo, Ketoconazole, Permeability enhancer, Formulation, Membrane https://www.ijper.org/article/52/4s2/s158-s163 2026-04-20T07:42:25.250739+00:00 Role of Communication Skill and Good Documentation Practice in the Overall Development of the Pharmacy Graduates in India: An Observational Study with Classroom Record-Daily Laboratory Record-Human Resource Record (CR-DR-HR) Model 2018-11-28 10.5530/ijper.52.4s.94 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s2-158.pdf Objective: The aim of this observational research study was to bring up the issues related to Communication skill (CS) and Good documentation practice (GDP) in one of the pharmacy college in India and its impact on the students in their overall personality development and job perspectives. These skills are like an accelerator which is required to facilitate the smooth sailing of the business. Methods: The new study model was developed and employed to conduct this observational research study for Communication skill, Good documentation practice, B. Pharm, M. Pharm, Human resource, Curriculum https://www.ijper.org/article/52/4s1/s102-s107 2026-04-20T06:43:19.386262+00:00 Essential Oil Composition of Some Sage (Salvia spp.) Species Cultivated in İzmir (Turkey) Ecological Conditions 2018-08-17 10.5530/ijper.52.4s.83 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-102.pdf Background: Salvia L., the largest genus of Lamiaceae, includes about 1000 species, widespread throughout the world. This genus is represented, in Turkish flora, by 99 species and 113 taxa, 58 of which are endemic. Some members of this genus are of economic importance since they have been used as herbal tea, flavouring agents in perfumery and cosmetics. Some sage (Salvia L. ) species has been credited with a long list of medicinal uses: e.g. spasmolytic, antiseptic, astringent. Objective: In pre Salvia spp, Sage, Cultivation, Essential oil, Chemcial composition https://www.ijper.org/article/52/4s1/s140-s145 2026-04-20T06:42:24.263675+00:00 Enhancement of Phytochemical Compounds Using Biotic and Abiotic Elicitors in Purple Coneflower (Echinacea purpurea L.) 2018-08-17 10.5530/ijper.52.4s.90 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-140.pdf Background: Phytochemicals also known secondary metabolites, naturally occurring in medicinal and aromatic plants, are of considerable importance for plant survival and human health. Objective: The objective of this study was to increase accumulation of caffeic acid and alkamide, using biotic and abiotic stresses conditions driving cell defense systems, in cell suspension cultures in purple coneflower (Echinacea purpurea L.). Methods: As biotic and abiotic elicitors, yeast extract (0, 25, 50 and Alkamide, Caffeic acid, Callus culture, Secondary metabolites https://www.ijper.org/article/52/4s1/s146-s150 2026-04-20T06:42:17.756426+00:00 Development of Geospatial Model for Preparing Distribution of Rare Plant Resources Using UAV/Drone 2018-08-17 10.5530/ijper.52.4s.91 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-146.pdf Background: The study of functioning of ecosystems is significant with understanding the composition and distribution of plant resources at spatial and temporal scales. For comprehensive plant survey, the traditional methods are not accurate and it’s not possible at inaccessible areas. The remote sensing techniques with GIS and GPS are more helpful in acquiring the information in less time with more frequency at multiple altitudes. Objective: This study was proposed a remote sensing, image proce Rare plant resource, Remote sensing, GIS, GPS, UAV, Drone and geospatial, model https://www.ijper.org/article/52/4s1/s128-s132 2026-04-20T06:42:36.797446+00:00 Assessment of Antioxidant Activity of Giant Snowdrop (Galanthus elwesii Hook) Extracts with Their Total Phenol and Flavonoid Contents 2018-08-17 10.5530/ijper.52.4s.88 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-128.pdf Background: The aim of this study was to determine total phenolic and flavonoid contents and antioxidant activities of Giant Snowdrop (Galanthus elwesii Hook). Objective: Giant Snowdrop, the second most common snowdrop in cultivation, has a long traditional use in folk medicines as it contains some alkaloids and phenolics. Material and Methods: The plant material was grown in Amasya province of Turkey during autumn-winter growing period in 2016-2017. The plant samples were taken from different o Galanthamine, Gallic acid, HPLC, Phenolic compounds https://www.ijper.org/article/52/4s1/s71-s76 2026-04-20T06:44:39.259152+00:00 Cypermethrin-Induced in vitro Alterations on Oxidative Stress and Quality of Salmo coruhensis Spermatozoa 2018-08-17 10.5530/ijper.52.4s.78 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-71.pdf The use of insecticides has been increasing along with increasing agriculture activities and has caused deleterious environmental impacts. Non-target organisms in particular, including fish, are affected by pesticides. In this work, the impacts of cypermethrin (CYP) on sperm oxidative stress markers and sperm motility were investigated in vitro. The CYP concentrations were 0 μg L-1 control, ethanol), 1.025 μg L-1, 2.05 μg L-1 and 4.1 μg L-1. Lipid peroxidation [Malondialdehyde (MDA)], non-enzyma Cypermethrin, Oxidative stress parameters, Salmo coruhensis, Sperm cell https://www.ijper.org/article/52/4s1/s16-s22 2026-04-20T06:45:09.498045+00:00 Development of Fluconazole Suppositories for the Treatment of Candida Infection of Genitourinary Tract 2018-08-17 10.5530/ijper.52.4s.71 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-16.pdf Background: Vulvovaginal candidiasis is a communal problem in virtually all the women which is caused by Candida albicans. Objective: Aim of the present study was to prepare and characterize vaginal suppositories of fluconazole for the treatment of vulvovaginal candidiasis. Methods: Fluconazole suppositories were prepared using water soluble and fatty bases. Bases and their proportions used were selected in such a way that they have flexibility in storage conditions unlike conventional supposito Vulvovaginal candidiasis, Candida albicans, Fluconazole, Fluconazole, suppositories, Vaginal suppositories, Vaginal infection, Agar, Hydroxypropyl, methylcellulose, Glycerol-gelatin, Cocoa butter, Bees wax https://www.ijper.org/article/52/4s1/s63-s70 2026-04-20T06:44:44.365541+00:00 Development of a Validated Stability Indicating Liquid Chromatographic Method for the Determination of Pterostilbene 2018-08-17 10.5530/ijper.52.4s.77 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-63.pdf Introduction: Pterostilbene, a stilbenoid possess diversified pharmacological activities. In the present study, a stability-indicating liquid chromatographic method was proposed for the determination of Pterostilbene in pharmaceutically available formulations. Materials and Methods: The chromatographic separation was achieved on Phenomenex C8 type column as stationary phase. UV detection was carried out at 219 nm. Pterostilbene was subjected to various stress conditions such as acidic, alkaline, Pterostilbene, Stability-Indicating, RP-HPLC, Validation, ICH guidelines https://www.ijper.org/article/52/4s1/s119-s123 2026-04-20T06:42:55.085576+00:00 An in vitro Study of Cytotoxic Activity of Euphorbia macroclada boiss on Mcf–7 Cells 2018-08-17 10.5530/ijper.52.4s.86 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-119.pdf Objective: The study was aimed to evaluate the cytotoxic activity of acetone extract of leaves, flower and body of Euphorbia macroclada boiss on human breast cancer cell line (MCF-7). Material: The cells were plated at a cell density of 1x105 cells in 96-well plates and grown with DMEM medium containing supplemented with 10% FBS and 1% penicillin. The cells were treated by different concentrations of acetone extract of Euphorbia macroclada boiss (10–1000 µg/mL) during 24, 48 and 72 h. The cytoto Euphorbia macroclada boiss, Cytotoxic activity, MCF-7, Breast cancer https://www.ijper.org/article/52/4s1/s47-s55 2026-04-20T06:44:52.597146+00:00 Synchronous Estimation of Glycopyrrolate and Formoterol in Bulk and Pharmaceutical Dosage Form by RP-HPLC Method 2018-08-17 10.5530/ijper.52.4s.75 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-47.pdf Objective: The objective is to develop and validate a fundamental, specific, novel and exact RP-HPLC (Reverse phase-High performance Liquid chromatography) methodology for the synchronous determination of Glycopyrrolate and Formoterol in pharmaceutical dosage form. Methods and Materials: The column utilized was BDS C18 (250mm x 4.6 mm, 5µm) in isocratic mode, with mobile phase consist of phosphate buffer and acetonitrile (40:60 v/v). The buffer was made by adding 1 ml of Orthophosphoric acid in Glycopyrrolate, Formoterol, Validation, HPLC https://www.ijper.org/article/52/4s1/s124-s127 2026-04-20T06:42:43.286939+00:00 The Physical, Chemical and Antioxidant Properties of the Leafs of Chaerophyllum byzantinum Boiss. Plants 2018-08-17 10.5530/ijper.52.4s.87 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-124.pdf Objective: Chaerophyllum byzantinum Boiss. is a plant which is popularly consumed in the Black Sea Region/Turkey. In spring, the leafs of the plant are mainly used for soup making. This study was carried out in order to determine the physical, chemical and antioxidant properties of the leafs of the plants consumed by people. Material and Methods: The plants were obtained from 8 different locations in Samsun/Turkey. The color, pH, dry matter, ash, crude protein, cellulose, crude fat, total phenol Chaerophyllum byzantinum Boiss, Edible plant, Antioxidant, Phenolics, Chemical, Color https://www.ijper.org/article/52/4s1/s37-s46 2026-04-20T06:44:56.499517+00:00 Simultaneous Quantitative Determination of Bupropion and its Metabolites by High Performance Liquid Chromatography Tandem Mass Spectrometry Detection: Application to Bioequivalence Study 2018-08-17 10.5530/ijper.52.4s.74 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-37.pdf Objective: A rapid, selective, sensitive, precise and accurate liquid chromatography in tandem with electro-spray ionization mass spectrometry method has been developed and validated for the simultaneous quantification of bupropion (BPR), hydroxyl bupropion (HBPR), erythrohydrobupropion (EHBPR) and threohydrobupropion (THBPR) in human plasma using only 100µL of human plasma sample. Methodology: Multi reaction monitoring detection was performed by electrospray ionization in the positive ion mode, Simultaneous determination, Liquid chromatography, Mass spectrometry, Bupropion, Metabolites, Plasma, Bioequivalence https://www.ijper.org/article/52/4s1/s151-s154 2026-04-20T06:42:11.111971+00:00 Use of Medicinal and Aromatic Plants in Therapeutic Gardens 2018-08-17 10.5530/ijper.52.4s.92 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-151.pdf Introduction: Today there is an accumulation of literature providing evidence for long and short term beneficial effects of living close to nature on various different health conditions ranging from psychological to physical disorders including depression, heart problems and diabetes. The results of these researches have given rise to the promotion of therapeutic gardens in outdoor spaces of healthcare establishments such as children’s hospitals, assisted-living houses, rehabilitation centers, a Healing garden, Health facilities, Stress, Assisted-living house, Planting, design https://www.ijper.org/article/52/4s1/s29-s36 2026-04-20T06:45:00.4124+00:00 Diosmin Phytosomes: Development, Optimization and Physicochemical Characterization 2018-08-17 10.5530/ijper.52.4s.73 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-29.pdf Background: Diosmin is a flavonoids glycoside that possesses different therapeutic activity include vascular-protecting agent used to help improving chronic venous insufficiency (CVI), haemorrhoids, etc. Diosmin is bioactive flavones constituent with wide range of biological activity. The poor solubility and dissolution rate limit its oral absorption and bioavailability. Aim: The aim of the present study is to develop diosmin - phospholipid complex (DN-PC) and characterized by physicochemical me Phytosome, Diosmin, Phophatidyl choline, Characterization https://www.ijper.org/article/52/4s1/s1-s6 2026-04-20T06:22:16.315749+00:00 OSCE-A New Assessment Method for Pharmaceutical Education 2018-08-17 10.5530/ijper.52.4s.68 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-1.pdf More reliable and validated method of assessment is the need of the hour for better summative evaluation of the students of pharmaceutical sciences. Competency or outcome based education models rely heavily on assessment methods. The objective structured clinical examination (OSCE) fits in to the gap and fulfills the requirement of testing the clinical/practical skills in more objective way. This review explores steps in planning and implementing an OSCE for institutes as well as high stakes exa OSCE, Assessment, Pharmaceutical Education, Clinical Skills, Summative, Evaluation https://www.ijper.org/article/52/4s1/s7-s10 2026-04-20T06:22:56.885435+00:00 Bridging the Gap Between Industry and Academia in Pharmaceutical Education 2018-08-17 10.5530/ijper.52.4s.69 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-7.pdf Though Pharmaceutical industries are growing at a rapid rate, Pharmacy curriculum is not taken pharmaceutical industry into consideration. Both industry and academia have different mindsets and goals. Pharma curriculum is mainly oriented towards the conventional needs of an industry which inturn creates a gap between industry and academia. Pharma graduates do not possess adequate skills to meet all industrial requirements. Students should expose more practical experience apart from the theoretic Pharmaceutical education, Industry, Academia, Training https://www.ijper.org/article/52/4s1/s23-s28 2026-04-20T06:45:05.396813+00:00 Simultaneous Determination of Some 5-Nitroimidazole Derivatives and Ciprofloxacin by High Performance Liquid Chromatography 2018-08-17 10.5530/ijper.52.4s.72 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-23.pdf Objective: An isocratic high performance liquid chromatographic method for simultaneous determination of Metronidazole, Tinidazole and Ciprofloxacin was developed. Method: Separation was achieved with a C18 (250x4.6 mm, 5 μm) column. Optimal chromatographic conditions were: mobile phase consisting of acetonitrile: 0.3% o-phosphoric acid modified with 0.1% triethylamine (20:80 v/v) at a flow rate of 0.7 mL min-1, at 30°C and wavelength of 300 nm. Results: The retention times were 4.92 min for Met Metronidazole, Tinidazole, Ciprofloxacin, RP-HPLC, Validation, Quality, control https://www.ijper.org/article/52/4s1/s77-s85 2026-04-20T06:43:53.806424+00:00 Neuroprotective Functions of Alpinia galanga in Forebrain Ischemia Induced Neuronal Damage and Oxidative Insults in Rat Hippocampus 2018-08-17 10.5530/ijper.52.4s.79 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-77.pdf Introduction: The rhizomes of Alpinia galanga (L.) Willd (Zingiberaceae) commonly known as greater galangal, a ginger substitute for food and was traditionally used as nervine tonic and stimulant. The present study was designed to screen the neuroprotective role of hydroalcoholic extract of rhizome of Alpinia galanga (HAAG) in transient forebrain ischemia induced neuronal damage and oxidative injury in the rat brain. Materials and Method: The transient forebrain ischemia was induced by bilateral Transient forebrain ischemia, Cornu ammonis, Oxidative stress, Alpinia, galanga (L.) Willd, lipid peroxidation, Actophotometer test https://www.ijper.org/article/52/4s1/s86-s90 2026-04-20T06:43:30.796826+00:00 Seasonal Changes of Phagocytic Activity Enhanced by an Acoholic Mint Extract in Cultured Rainbow Trout 2018-08-17 10.5530/ijper.52.4s.80 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-86.pdf Objective: We hypothesized that leukocyte numbers and their in vitro phagocytic activity in farmed rainbow trout are subject to negative influence of extreme temperatures for fish and that mint extract could alleviate these effects. Materials and Methods: Blood samples from farmed rainbow trout collected during winter and summer were subjected to leukocyte subpopulation counts (%) and carbon particle inclusion test to estimate the in vitro phagocytic activity after 15 and 30 min of incubation at Rainbow trout, Season, Leukocytes, Phagocytosis, Mint extract https://www.ijper.org/article/52/4s1/s133-s139 2026-04-20T06:42:32.140644+00:00 Detection of the Genotoxicity of Gentiana L. Extracts by Using RAPD-PCR and ISSR-PCR Techniques 2018-08-17 10.5530/ijper.52.4s.89 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-133.pdf Background: The RAPD- and ISSR-PCR techniques are offering an insight into the detecting the genotoxicity of Gentiana extracts. Objective: It is aimed with the present study, to detect the genotoxicity of methanol extracts of ten Turkish Gentiana L. taxa on germinated Allium cepa L. root tips. Methods: RAPD- and ISSR-PCR techniques were used for detection of genotoxicity of Gentiana extracts. Results: Four RAPD and three ISSR primers produced the reproducible polymorphic and monomorphic banding Gentiana L, Genotoxicity, RAPD-PCR, ISSR-PCR https://www.ijper.org/article/52/4s1/s91-s95 2026-04-20T06:43:27.106661+00:00 Prolonged in vivo Stinging Nettle Treatment Impacts on Functional Capacity of Leukocytes in Immunologically Mature Chickens 2018-08-17 10.5530/ijper.52.4s.81 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-91.pdf Objective: The experiment aimed at establishing the effects of an alcoholic Urtica dioica extract on the in vitro blastogenic response in antigen stimulated, immunologically mature chickens. Materials and Methods: Three equal groups (n=17) of 47 days old, Rock x Cornish chickens were subjected to oral administration of: a) 0.5 ml/chicken/ day of an alcoholic stinging nettle extract (I), b) 0.5 ml/chicken/day alcohol (II, solvent control), and c) 0.5 ml chicken/day water (III-environment control) Chicken, Immunologically mature, Leukocytes, Blast transformation, Nettle, extract https://www.ijper.org/article/52/4s1/s108-s114 2026-04-20T06:43:14.639552+00:00 Effect of Cadmium Application on Antimicrobial, Antioxidant and Total Phenolic Content of Basil Genotypes 2018-08-17 10.5530/ijper.52.4s.84 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-108.pdf Background: Exposure to heavy metals leads to increase in reactive oxygen species. Plants have many strategies to counteract the toxic effects of heavy metal stress by activating certain intermediary metabolic activities and making physiological adjustments. Objective: This study was designed to determine total phenolic contents and antimicrobial and antioxidant activities of eight Ocimum basilicum L. genotypes grown in a soil exposed to cadmium at different levels. Methods: Total phenolic conte Cadmium toxicity, Free radical scavenging activities Ocimum basilicum L https://www.ijper.org/article/52/4s1/s56-s62 2026-04-20T06:44:48.59442+00:00 Development and Validation of a RP-HPLC Method for the Determination of Ellagic Acid in Terminalia bellirica Extract and Single Herb Capsule of Terminalia bellirica 2018-08-17 10.5530/ijper.52.4s.76 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-56.pdf Objective: The present work describes development and validation of a simple, specific, sensitive, precise, reproducible and robust high performance liquid chromatographic method of analysis of Ellagic acid, as in Terminalia bellirica extract and from capsule formulation. A validated rapid HPLC–PDA method was developed for identification and quantification of Ellagic acid (EA) in the extracts prepared from the fruits of Terminalia bellirica available in India. Methodology: The separation was ach Terminalia bellirica, Ellagic acid, RP-HPLC, Validation, ICH Guidelines https://www.ijper.org/article/52/4s1/s11-s15 2026-04-20T06:25:00.130013+00:00 Impact of Concomitantly Administered Curcumin on Pharmacokinetics of Daclatasvir in Mice Under the Frame of Herb-Drug Interaction 2018-08-17 10.5530/ijper.52.4s.70 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-11.pdf Objective: Daclatasvir is a new orally acting antiviral drug for the treatment of hepatitis C virus (HCV). It is substrate of both P-glycoprotein (P-gp) and CYP3A4 which are involved in the major pharmacokinetic interaction between drug-drug or drug-food. Curcumin, a natural polyphenol extracted from Curcuma longa is used regularly and widely as food additive or dietary supplement. We surmised that curcumin may interfere with the pharmacokinetics of daclatasvir as curcumin is known to have poten Daclatasvir, Curcumin, Pharmacokinetic interaction, Herb-drug interaction, Food-drug interaction https://www.ijper.org/article/52/4s1/s96-s101 2026-04-20T06:43:23.251439+00:00 Antioxidant Capacity and Bioactive Contents of Mulberry Species from Eastern Anatolia Region of Turkey 2018-08-17 10.5530/ijper.52.4s.82 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-96.pdf In this study, we aimed to determine biochemical contents of white (Morus alba L.) and black (Morus nigra L.) mulberry genotypes grown in the Hakkari region. At the end of the study, organic acids, phenolic compounds, sugars, vitamin C and antioxidant capacities of mulberry species were determined. Black mulberry genotypes were found to contain higher antioxidant capacity than white mulberry genotypes. The highest antioxidant capacity was detected in the 30YK03 (25.55 µmolTE/g) black mulberry ge Mulberry, Phenolic compounds, Organic acids, Sugars https://www.ijper.org/article/52/4s1/s115-s118 2026-04-20T06:43:07.517869+00:00 Effect of Led Drying on Drying Behavior of Prunus domestica L. Fruit 2018-08-17 10.5530/ijper.52.4s.85 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPhaEdRes-52-4s1-115.pdf Background: Energy efficiency is becoming increasingly important in storing foods preserving their own characteristics and fruits and vegetables by drying in terms of selflife as well. Objectives: Since the Black Sea Region of Turkey is rainy and extremely humid during the harvest period of fruits and vegetables, the region is not suitable for natural drying of fruits and vegetables. For this reason, additional energy is needed for drying in the region. The Prunus domestica L. fruit that grown n Food drying, Sun drying, LED technology, Drying curve https://www.ijper.org/article/52/4/626-634 2026-04-20T06:04:47.972471+00:00 Evaluation of in vitro Anticancer Activity of Vulpinic Acid and its Apoptotic Potential Using Gene Expression and Protein Analysis 2018-06-20 10.5530/ijper.52.4.73 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-4-626.pdf Lichens and their secondary metabolite are still among the many unexamined natural sources in the drug industry. This study was designed to evaluate the cytotoxic effects of vulpinic acid lichen secondary metabolite and 6.25, 12.5, 25, 50, 100, 200 and 400 µM concentrations that treat cancer cell lines (CaCo2, HepG2, Hep2C, RD Wehi) and normal cells (Vero and L929) by MTT assay. The aim of this study was to determine the apoptotic effect of vulpinic acid on a molecular level. The determination o Vulpinic acid, Apoptotic effect, qRT-PCR, Western blot https://www.ijper.org/article/52/4/575-580 2026-04-13T05:55:11.682809+00:00 Presentation and Quality Evaluation of a Novel Learning Method for Pharmacy Students in Drug Information Course 2018-06-20 10.5530/ijper.52.4.66 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-4-575.pdf Introduction: Personal computers or laptops and smartphones has been used to change the lecture based traditional class to an interactive workshop to educate the knowledge and skills necessary for using drug information resources in clerkship courses. Methods: After the needs assessment and educational facilities, the appropriate drug information questions corresponding to each source were designed. Students used their laptops and smartphones to find the answer to drug information questions. The Drug information education resources, Laptop, Smart phone, Pharmacy, clerkship course https://www.ijper.org/article/52/4/581-586 2026-04-13T05:55:11.682809+00:00 Design, Development and Characterization of Nano Structured Lipid Carrier for Topical Delivery of Aceclofenac 2018-06-20 10.5530/ijper.52.4.67 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-4-581.pdf Objective: Aceclofenac is non steroidal anti inflammatory drug (NSAID) and is considered to be first line drug in treatment of rheumatoid arthritis, osteo arthritis and ankylosing spondylitis. Aceclofenac undergoes first pass metabolism when taken orally and it also produces some GI problems. The limitations of oral administration have been overcome by topical route. Drug aceclofenac has been loaded with lipid carriers and then formulated in to topical formulation with the objective of prolongin Aceclofenac, Ultra sonication, High speed homogenization, Entrapment, efficiency, in-vitro release studies https://www.ijper.org/article/52/4/594-601 2026-04-13T05:55:11.682809+00:00 Quercetin as a Modulator of Diabetic Macrovascular Complications in Murine and Chick Embryo Models 2018-06-20 10.5530/ijper.52.4.69 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-4-594.pdf Background: Quercetin, a bioflavonoid, with wide natural occurrence has been found to possess numerous pharmacological benefits. Aim: The present work deals with exploring efficacy of Quercetin against diabetic macrovascular complications taking the aid of the high fat diet fed-low dose streptozotocin rat model. The use of the chick embryo model in this regard was attempted with an aim to address the growing ethical concerns for the use of higher animals in biological experiments. Methods: High In ovo, Diabetic macrovascular complications, Chick embryo, Quercetin https://www.ijper.org/article/52/4/684-690 2026-04-20T06:08:11.42246+00:00 Stability Indicating HPLC Method using Core Shell Stationary Phase for the Determination of Related Substances in Levocetirizine Dihydrochloride Oral Solution 2018-06-20 10.5530/ijper.52.4.79 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-4-684.pdf Introduction: Levocetirizine (LCZ) is a new generation antihistamine drug used for the allergic symptoms resulting from various diseases. The present research work focuses on the development of a simple and precise HPLC method for the effective separation and quantitative determination of LCZ and its impurities. Objectives: Eight potential related impurities of LCZ were separated and identified in the bulk drug as well as oral solution dosage form. Results: The separation was achieved on a core HPLC, Core shell, Related Substances, Levocetirizine dihydrochloride https://www.ijper.org/article/52/4/587-593 2026-04-13T05:55:11.682809+00:00 Comparative Single Dose Pharmacokinetics and Bioavailability Studies of Saquinavir, Ritonavir and their Optimized Cyclodextrin Complexes after Oral Administration into Rats using LC-MS/MS. 2018-06-20 10.5530/ijper.52.4.68 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-4-587.pdf Purpose: To compare pharmacokinetics and bioavailability of saquinavir (SQV) and ritonavir (RTV) and their optimized cyclodextrin complexes of anti-retro viral drugs after oral administration into rats. Methods: Rats were fasted overnight and dose equivalent to 10 mg/kg was administered orally via feeding tubes. Serial blood samples were collected, and plasma concentrations of both drugs and their complexes were determined using liquid chromatography tandem mass spectrometry, LCMS/MS. Results: A Oral, LCMS/MS, Plasma, Bioavailability https://www.ijper.org/article/52/4/691-698 2026-04-20T06:08:50.112117+00:00 Identification of a New Potential Reductase Inhibitor as an Anti-Tubercular Agent for Enoyl-Acp Reductase Inha Gene of Mycobacterium tuberculosis in Comparison with PT70 (5-Hexyl-2-(2-Methylphenoxy) Phenol) 2018-06-20 10.5530/ijper.52.4.80 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-4-691.pdf Bacterium Mycobacterium tuberculosis is the causative agent for the disease tuberculosis (TB) and is responsible for more than ten million different infections with an additional accountability for about two million deaths every year. PT70 molecule as described in the literature acts as a drug in the market, which has been utilized as a curative agent for the disease. However, for these commercialized anti-tuberculotic drugs the causative agent that is Mycobacterium tuberculosis is becoming drug Anti-tuberculotic, PT70, Pharmacophore, Binding energy, Membrane, Permeability, Drug discovery https://www.ijper.org/article/52/4/707-717 2026-04-13T05:55:11.682809+00:00 Exploring Novel ALK Inhibitors using Energy Based Pharmacophore Mapping and High-throughput Virtual Screening 2018-06-20 10.5530/ijper.52.4.82 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-4-707.pdf Introduction: Recent years has witnessed major paradigm shifts in the treatment of NSCLC with the emergence of biomarkers and targeted therapies. Most importantly, ALK is a validated biomarker and its inhibition using targeted therapies have had significant effects on patients suffering from NSCLC. However, emergence of drug resistance has limited the usage of these agents in the patients. Objective: In the present objective, e-pharmacophore based virtual screening was employed to discover poten ALK, E-Pharmacophore model, TIPdb database, PHASE, GLIDE https://www.ijper.org/article/52/4/635-643 2026-04-13T05:55:11.682809+00:00 Identification of Degradant Products of Saroglitazar by UPLC Tandem Mass Spectroscopy and Attenuated Total Reflection FTIR Techniques 2018-06-20 10.5530/ijper.52.4.74 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-4-635.pdf Saroglitazar is a newly approved oral hypoglycemic drug by FDA. Although the drug entered the market, there are no reports on its degradation products till date. To identify the degradation products of saroglitazar during the stability studies, a RP-HPLC method was developed and validated as per ICH guidelines. The samples were eluted using acetonitrile and phosphate buffer (pH 7.4, 50:50 v/v) as a mobile phase over Kromasil 100- 5C18 (250×4.6 mm, 5µm) column. The analytes were monitored by UV d Saroglitazar, Degradation products, Reverse phase high performance liquid, chromatography, Mass spectroscopy, Infra-red spectroscopy https://www.ijper.org/article/52/4/550-557 2026-04-20T05:55:33.203647+00:00 An Overview on the Insulin Preparations and Devices 2018-06-20 10.5530/ijper.52.4.64 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-4-550.pdf Insulin preparations are the mainstay in the management of type 1 along with various type 2 diabetes. Available insulin preparations are either short-acting or long-acting or mixture to mimic the physiological insulin secretion and their doses need to be individualized. Attempting to imitate normal secretion of insulin can be valuable paradigm for understanding and providing effective therapy. This review provides an outline about the composition, use, route of administration, injection site, ph Short-acting insulin, Long-acting insulin, Mixture, Analogues, Handling, Devices, Diabetes https://www.ijper.org/article/52/4/699-706 2026-04-13T05:55:11.682809+00:00 A Combination of Pharmacophore Modeling, Molecular Docking and Virtual Screening Study Reveals 3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)- 4H-Chromen-4-One as a Potential Anti-Cancer Agent of COT Kinase 2018-06-20 10.5530/ijper.52.4.81 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-4-699.pdf Background: COT (Tpl2/MAP3K8) is a Serine/ Threonine protein kinase which plays a crucial role in the production of TNF-alpha through the phosphorylation of MEK, ERK pathway and the production of other pro-inflammatory cytokines. Its inhibition has been shown as important to reduce inflammatory diseases and cancer. Material and Methods: Combined Ligand-based and Structure-based pharmacophore model was developed for finding out the potential anticancer agents. These combined pharmacophore model w COT Kinase, Docking, Pharmacophore model, Anticancer, LigandScout https://www.ijper.org/article/52/4/655-665 2026-04-13T05:55:11.682809+00:00 Design, Synthesis and Evaluation of Some Novel 1-phenyl-3-(5-phenyl-1H-imidazol-1-yl) Thiourea Derivatives as Anti-HIV Agents. 2018-06-20 10.5530/ijper.52.4.76 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-4-655.pdf Objective: In the present study, a series of nineteen compound of 1-phenyl-3-(5-phenyl1H-imidazol-1-yl) thiourea derivatives (5a-9b) were designed, synthesized, characterized by physicochemical and spectral data (IR, 1H NMR, and mass spectroscopy) and evaluated for their Anti-HIV activity with the aim to develop novel substituted imidazole derivatives with broad-spectrum chemotherapeutic properties. Methods: Compounds (5a-9b) were designed by using Glide 5.0 to carry out binding mode analysis of Molecular docking, Imidazole derivatives, Reverse transcription, Non-nucleoside, reverse transcriptase inhibitors (NNRTI), Anti-HIV https://www.ijper.org/article/52/4/602-609 2026-04-20T06:02:36.941262+00:00 Long-Term Effects of Metabolic Stress on Human Malignant Melanoma Cell Line 2018-06-20 10.5530/ijper.52.4.70 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-4-602.pdf Introduction: Tumour is a heterogeneous tissue consisting of cells with different levels of metabolic activity. Often the outer layer cells of a tumour have more optimal conditions to grow/proliferate compared to the inner cells. Objective: The aim of the current study was to study the reactions of malignant melanoma A375 cells in exposure to different levels of metabolic stress and their ability to returning to life upon re-exposure to optimum nutritional conditions. Methods: A375 cells, at ear A375, Neoplasm, Serum, Starvation, Metabolic Stress https://www.ijper.org/article/52/4/544-549 2026-04-13T05:55:11.682809+00:00 Regulatory Requirements and Registration Procedure for Generic Drugs in USA 2018-06-20 10.5530/ijper.52.4.63 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-4-544.pdf A generic drug is more efficient, safe and low-cost alternative of the innovator or branded drug in the market. They are similar to the branded drugs in strength, quality, purity and their safety and efficacy have been proven since they have been in the market for a longer time. The availability of generic medicine should be made easier throughout the world. The US has one of the most demanding regulatory authorities and registration of drug products will be a long process if not complied with t Generic drugs, Common technical document, ANDA, USFDA https://www.ijper.org/article/52/4/676-683 2026-04-13T05:55:11.682809+00:00 Biomarker Quantification: Development of Fit for purpose LC-MS/MS Method for Determination of Methyl guanidine in Mice Urine 2018-06-20 10.5530/ijper.52.4.78 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-4-676.pdf Introduction: Accurate quantitation of biomarkers is always challenging, it becomes really tedious when biomarker has poor retention on chromatographic column and possess a chemical structure resistant for derivatisation. Methyl guanidine is product of protein catabolism, normally gets excreted in urine. Endogenous methyl guanidine concentrations in urine increases if there is reduce urine production or conversion of creatinine to methyl guanidine as proposed in patients with chronic renal failu Methyl guanidine, Biomarker Quantification, Mice urine, Surrogate matrix, Synthetic urine, LC-MS/MS method https://www.ijper.org/article/52/4/610-617 2026-04-13T05:55:11.682809+00:00 Antineoplastic Approach of Semecarpus anacardium Leaves against N-Nitroso Diethylamine Initiated Hepatocellular Carcinoma 2018-06-20 10.5530/ijper.52.4.71 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-4-610.pdf Objective: To evaluate the effect of MESA on NDEA induced hepatocellular carcinoma on Sprague Dawley rats. Methodology: Semecarpus anacardium commonly known as ‘marking nut tree’ is a rich antioxidant and in Ayurveda it has been used for treatment of various forms of cancer. Methanolic extract of leaves of Semecarpus anacardium (MESA) was studied for its potential antioxidant property both in vitro and in vivo. NDEA 200 mg/kg, single i.p was the hepatocarcinogen while 200 mg/kg and 400 mg/kg of Semecarpus anacardium, Hepatocellular carcinoma, N-nitroso diethylamine, Alpha fetoprotein, Liver marker enzymes https://www.ijper.org/article/52/4/618-625 2026-04-20T06:03:58.892293+00:00 Gastroprotective Effect of Hydro-Alcoholic Extract of Polygonum bistorta Lin Root in IndomethacinInduced Gastric Ulcers in Sprague Dawley Rats 2018-06-20 10.5530/ijper.52.4.72 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-4-618.pdf Objective: Gastroprotective effect of hydro-alcoholic extract of Polygonum bistorta Linn root (HEPB) was investigated in indomethacin-induced gastric ulcer in Sprague Dawley rats. Background: Polygonum bistorta has been used as hemostatic drug in Unani system of medicine due to its cold and dry temperament. Methods: The rats were grouped into six groups each consisting of five rats. Group-I, group-II, group-III, group-IV, group-V and group-VI rats received 1 mL/kg/day 1% carboxymethyl cellulose Polygonum bistorta, Indomethacin, Oxidative stress, Ulcer index, PUD https://www.ijper.org/article/52/4/558-574 2026-04-20T05:57:43.870251+00:00 My Opinions Matter! How Perspectives, Knowledge and Expectations Matter in Moderating the Success of New Pharmaceutical Services Implementation in Malaysia 2018-06-20 10.5530/ijper.52.4.65 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-4-558.pdf The Malaysian Government through the National Health Policy aims to improve health outcomes through public pharmaceutical healthcare services. Pharmacy Value Added Services (PVAS) was introduced as a matter of public pharmaceutical health policy. PVAS is an important service to improve clinical outcomes by improving compliance, monitoring and even information dissemination. However, adoption rates are low and therefore hampering the achievement of national health policy goals. Our objective is t Pharmacy Value Added Services, Perspectives, Intentions, Theory of Planned, Behavior, Moderation https://www.ijper.org/article/52/4/666-675 2026-04-13T05:55:11.682809+00:00 Application of 3D QSAR and Docking Studies in Optimization of Perylene diimides as Anti Cancer Agent 2018-06-20 10.5530/ijper.52.4.77 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-4-666.pdf Introduction: Telomerase is an enzyme which binds to telomeres and increases its length which leads to extension of lifespan of cells. These enzymes are expressed at detectable levels in cancer cells which makes an attractive target for cancer therapy. The G Quadruplex ligands which bind to telomerase with respect to duplex genomic DNA is of special importance. The Perylene di imides are selected, designed and QSAR study has been done, finally from the QSAR results’ docking has been done by G4LD Perylene Derivatives, QSAR Plus, G-Quadruplex Ligand Database, Docking https://www.ijper.org/article/52/4/644-654 2026-04-13T05:55:11.682809+00:00 Design, Synthesis and Evaluation of 4-Aminopyridine Analogues as Cholinesterase Inhibitors for Management of Alzheimer’s Diseases 2018-06-20 10.5530/ijper.52.4.75 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-4-644.pdf Introduction: Alzheimer’s disease (AD) is a slowly progressive devasting neurodegenerative disorder of central nervous system manifested by deterioration of memory, cognitive functions, behaviour change and impairment in performing activities of daily life. Neurochemical studies of patients suffering from AD demonstrate selective loss of cholinergic neurons, low concentration of acetylcholine (Ach) in the selective areas of brain such as cortex and hippocampus. Objective: A series of new semicar 4-aminopyridine, Acetylcholinesterase, Passive avoidance test, Rivastigmine https://www.ijper.org/article/52/3/532-539 2026-04-13T05:55:13.604546+00:00 Oral Mucositis Severity Assessment by Supplementation of High Dose Ascorbic Acid During Chemo and/or Radiotherapy of Oro-Pharyngeal Cancers – A Pilot Project 2018-06-17 10.5530/ijper.52.3.61 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-532.pdf Introduction: Prevention or control of oral mucositis during cancer therapy can lead to better treatment outcome. The present study was aimed to evaluate the effect of high dose oral ascorbic acid on severity of oral mucositis induced during treatment period. Methods: After informed consent, patients of both the gender with age 18-70 years, were divided into: Group A (n=19) served as controls with no intervention, Group B (n=20) undergoing chemo-radiotherapy and Group C (n=20) receiving conventi Ascorbic acid, Mucositis, Grading of mucositis, Radiotherapy, Chemotherapy https://www.ijper.org/article/52/3/398-407 2026-04-20T05:36:20.263275+00:00 Formulation and Evaluation of Oral Fast Dissolving Films of Poorly Soluble Drug Ezetimibe Using Transcutol Hp 2018-06-17 10.5530/ijper.52.3.46 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-398.pdf Introduction: The objective of the present formulation research is to deliver the drugs at a faster rate and to provide immediate onset of action in a shorter period of time with improved bioavailability. Materials and Methods: Ezetimibe, a gift sample from Lupin Ltd., Pune, Transcutol HP, a gift sample from Gattefosse India Pvt. Ltd., Goa., HPMC E5, HPMC E6, HPMC E15 are gift samples from Colorcon India Pvt. Ltd. Results and Discussion: Among prepared formulations coded E1 to E20, formulation E Ezetimibe, Transcutol HP, HPMC E5, HPMC E6, HPMC E15, Pectin https://www.ijper.org/article/52/3/416-425 2026-04-20T05:37:38.35121+00:00 Antiparasitic Efficacy of Artemisia ludoviciana Nutt. (Asteraceae) Essential Oil for Acanthamoeba castellanii, Leishmania infantum and Trichomonas vaginalis 2018-06-17 10.5530/ijper.52.3.48 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-416.pdf Background: Artemisia ludoviciana Nutt. (Asteraceae) is an aromatic, herbaceous, perennial plant and known commonly name as “White Sage”, “Black Sage”, “Prairie Sage” or “Cudweed Sagewort”. It is traditionally used as an antispasmodic, anthelminthic, antidiarrhoeal, stomachic, hepatic colic, appetizer, and regulator of menstruation, antimalaric and antiparasitic efficiancy. Objective: The essential oil composition of the flowering herb of A. ludoviciana (AL) was investigated and for the first ti Artemisia ludoviciana, Camphor, 1, 8-Cineole, Camphene, Antiparasitic, effect, GC-FID, GC/MS https://www.ijper.org/article/52/3/492-504 2026-04-13T05:55:13.604546+00:00 A Correlative Multi-Spectroscopy and Docking Study for the Modeling of Drug (Luteolin and Quercetin) Binding to Bovine Serum Albumin– A Tool for the Determination of Binding Characteristics to Receptor Proteins 2018-06-17 10.5530/ijper.52.3.57 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-492.pdf The in vitro in silico experimental flow (multi- spectroscopy and docking) demonstrated the binding of Luteolin and Quercetin separately with Bovine Serum Albumin. For the first time, we are reporting the relative UV-visible spectroscopy-based hypsochromic shifts for both luteolin (3nm) and quercetin (4.1 nm) respectively. The drug-induced conformational change may lead to the possible shift in the tryptophan residue to a more hydrophobic environment. Our demonstration of an increased static que Bovine Serum Albumin (BSA), Luteolin/Quercetin, Fluorescence spectroscopy, FT-IR spectroscopy, AUTODOCK/LIGPLOT https://www.ijper.org/article/52/3/449-455 2026-04-13T05:55:13.604546+00:00 Antibacterial Evaluation of Cuprous Oxide Nanoparticles Synthesized Using Leaf Extract of Callistemon viminalis 2018-06-17 10.5530/ijper.52.3.52 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-449.pdf Objectives: Nanoparticles synthesis via green approach is a scorching theme of research nowadays as it minimizes the use of harmful chemicals. Not much work has been done on bio reduction of copper salts; therefore our present work was focused on green synthesis of copper oxide nanoparticles using leaf extract of Callistemon viminalis. Methods: Bio reduction method was used for preparation of copper oxide nanoparticles using Callistemon viminalis leaf extract. Synthesis was carried out at three Bio reduction, Copper oxide, Green synthesis, Cuprous oxide, Metallic, nanoparticles, Callistemon viminalis https://www.ijper.org/article/52/3/363-373 2026-04-13T05:55:13.604546+00:00 Carboxymethyl Tamarind Seed Kernel Polysaccharide Formulated into Pellets to Target at Colon 2018-06-17 10.5530/ijper.52.3.42 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-363.pdf Objective: Tamarind seed polysaccharide (TSP) modifying to carboxymethyl tamarind seed kernel polysaccharide (CMTSP) could be potential polymer over synthetic one to target colon diseases. Ibuprofen was loaded in CMTSP to achieve colon targeted sustained action of pellets due to viscous nature of CMTSP. Methods: Ibuprofen loaded CMTSP pellets prepared by extrusion spheronization technique were optimized using three-level two-factor full factorial design. Results: Higher was the amount of CMTSP; Carboxymethyl tamarind seed polysaccharide, Extrusion, Spheronization, Pellets, Colon drug delivery, Ibuprofen, Rat caecal content https://www.ijper.org/article/52/3/408-415 2026-04-13T05:55:13.604546+00:00 Development and Evaluation of a Novel Drug Delivery System for Albendazole 2018-06-17 10.5530/ijper.52.3.47 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-408.pdf Introduction: The main objective of the present study was to develop and evaluate long circulating pegylated niosomal formulation of albendazole (ABZ). It was hypothesized thatpegylated niosomes would increase the systemic residence time of albendazole in the treatment of echinococcosis thus obviating frequent doses of albendazole. Materials and methods: ABZ was received as a gift sample from SeQuent Scientific Limited, Mahad. Span 60 niosomes pegylated with Distearoyl-sn-glycero-3-phosphoethano Niosomes, Prolonged release, PEG-DSPE, Pegylation, Albendazole https://www.ijper.org/article/52/3/505-513 2026-04-20T05:45:18.705028+00:00 Synthesis and Anti-Inflammatory Activity Evaluation of 5-(1-Benzyl-1H-[1,2,3]Triazol-4-yl)-4-Phenyl4H-[1,2,4]Triazole-3-Thiol Derivatives 2018-06-17 10.5530/ijper.52.3.58 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-505.pdf Context: Aims: In order to search new compounds with higher anti-inflammatory activities and lower toxicity. 1,2,3-triazole and 1,2,4-triazole derivatives were designed and synthesized, and then the anti-inflammatory activities (in vitro) were evaluated. Settings and Design: The triazole derivatives were designed on the basis of association principle. Methods and Material: 19 benzo[d]-5-(1-Benzyl-1H-[1,2,3]triazol-4-yl)-4- phenyl-4H-[1,2,4]triazole-3-thiol derivatives were synthesized and evalua Synthesize, Anti-inflammatory, RAW 264.7 cell, IL-6 https://www.ijper.org/article/52/3/472-479 2026-04-13T05:55:13.604546+00:00 Synthesis and Antimalarial Activity of Lawsone Mannich Base Derivatives 2018-06-17 10.5530/ijper.52.3.55 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-472.pdf Introduction: The emergence of multi-drug resistant strains of Plasmodium falciparum has increasingly become a serious health problem worldwide. To address this challenging issue, there is an urgent need to discover and develop novel and potent antimalarial agents. Materials and Methods: A new series of lawsone Mannich base derivatives were synthesized, characterized (IR, NMR and Mass) and evaluated for in vitro for antimalarial activity against chloroquine (CQ)-sensitive and CQ-resistant strain Lawsone, Mannich bases, Aminonaphthoquinone, Plasmodium falciparum, Resistant malaria https://www.ijper.org/article/52/3/540-542 2026-04-20T05:49:51.22884+00:00 Immune Thrombocytopenia (ITP) in a Patient with Relapsing-Remitting Multiple Sclerosis (RRMS) Associated with b-Interferon-1α Treatment 2018-06-17 10.5530/ijper.52.3.62 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-540.pdf Immune thrombocytopenia is an isolated thrombocytopenia not related to other etiologies of thrombocytopenia.1 The diagnosis relies mainly on exclusion of other conditions.2,3 The incidence of ITP among adults has been estimated to be 3.3 per 100,000 persons in Europe according to a review study in 2009.4 ITP may be induced by drugs.2 In this type of ITP, a drug induces production of antibodies against platelets and causes destruction and reduction of platelets.2 This is usually transient and imp Cinnovex, Immune thrombocytopenia, neurologic https://www.ijper.org/article/52/3/442-448 2026-04-13T05:55:13.604546+00:00 The Antioxidant Enzymatic Activity of Date Palm Seedlings Under Abiotic Drought Stress 2018-06-17 10.5530/ijper.52.3.51 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-442.pdf Objective: the present research was focused to evaluate the date palm resistance to osmotic stress exerted by three concentrations of poly ethylene glycol 6000 in three months seedlings as reflected by the change in phenolic and flavonoid content and the activity of catalase, peroxidase and polyphenol oxidase. Materials and Methods: The phenolic and flavonoid content and the target enzyme’s activity was estimated at four time points; 0,1,3,7 days. Results and Discussion: The phenolic and flavono Date palm, Phenol, Flavonoid, Catalase, Peroxidase, Polyphenol oxidase https://www.ijper.org/article/52/3/389-397 2026-04-13T05:55:13.604546+00:00 Use of Black Gram Polysaccharide Mucilage as Release Retardant in the Development of Sustained Release Matrix Pellets of Ciprofloxacin Hydrochloride 2018-06-17 10.5530/ijper.52.3.45 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-389.pdf Ciprofloxacin HCl is a BCS class III drug with high solubility and low permeability. It is a second generation fluoroquinolone antibiotic used in the treatment of mild to moderate urinary and respiratory tract infections. It has half-life of 4-5 h and bioavailability about 70%. The main objective of this research work was to develop sustained release matrix pellets of ciprofloxacin HCl to obtained better delivery of ciprofloxacin HCl to the stomach and the proximal parts of the small intestine b Sustained release drug delivery system, Ethyl cellulose, Black gram, polysaccharide, Pelletization, in vitro drug release study https://www.ijper.org/article/52/3/334-341 2026-04-13T05:55:13.604546+00:00 Enantioseparation of D- and L- isomers of Chiral Drugs for Improving their Bioavailability: Some Techniques Including Micellization with Gemini Surfactants 2018-06-17 10.5530/ijper.52.3.39 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-334.pdf The enantiopure drugs are essential for disease treatment as the human body is amazingly chiral selective. Nearly 50% of drugs are chiral but the pharmacological activity resides with only one isomer, termed as eutomer, whereas the other isomer which is inactive or less potent metabolizes by a different way in the body. This toxic isomer in a racemic drug causes side-effects, genetic disorder or may cause even death if taken in high dosage. Therefore, role of stereochemistry in drug action getti Enantioseparation, Micellization, Chiral drugs, in-vivo bioavailability, Pharmacological activity https://www.ijper.org/article/52/3/514-524 2026-04-13T05:55:13.604546+00:00 Energy Based Pharmacophore Modelling and Docking Studies for Determining Potent Inhibitor Against M2 Proton Channel of Influenza Virus 2018-06-17 10.5530/ijper.52.3.59 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-514.pdf M2 protein, a crucial glycoprotein present on the viral envelope of Influenza A virus plays an important role in the replication and budding of influenza A virus in the host organism. Due to its primal role in the life cycle of influenza A virus, it is targeted by many potent drugs like amantadine and rimantadine. The emergence of M2 protein mutants in the recent years has rendered these drugs ineffective. Keeping this in our minds, an investigation was performed to determine potent inhibitors o Influenza A virus, M2 protein, E-Pharmacophore model, Virtual screening, DrugBank database https://www.ijper.org/article/52/3/351-362 2026-04-13T05:55:13.604546+00:00 Service Quality Gap Measurement in Pharmaceutical Educational Institutes: An Empirical Analysis for Model Development 2018-06-17 10.5530/ijper.52.3.41 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-351.pdf Perspective: One can observe the sea changes that have been taken place in the Indian pharmaceutical business environment. There are challenges for this section and which is possible to overcome by quality human resources. In fact, we have experienced mushroom growth of pharmaceutical education institutes (PEIs) without producing of the employable graduates. Probably this is due to poor service offerings from PEIs. Objective: Hence, the purpose of the present research to develop service quality Pharmaceutical education, Higher education, Service quality management, Gap analysis, Factor analysis https://www.ijper.org/article/52/3/525-531 2026-04-13T05:55:13.604546+00:00 Self-Medication Awareness for Skin Rash Management by Indian University Students - A Questionnaire-Based Survey Study 2018-06-17 10.5530/ijper.52.3.60 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-525.pdf The aim of the questionnaire-based study was to survey on the awareness and usage of topical over-the-counter (OTC) products used for the management of skin rash conditions by Indian University students along with their knowledge about the product’s safety, contraindications and adverse effects. One hundred and fourty five student members (comprising of 86 of them from pharmacy stream and 59 of them belongs to other department) of which 76 were female, took part in this survey study. The average Allopathic, Ayurvedic, Skin rash, Topical, Survey, Awareness https://www.ijper.org/article/52/3/342-350 2026-04-13T05:55:13.604546+00:00 “Breaking Bad” Television Series Explained to Students 2018-06-17 10.5530/ijper.52.3.40 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-342.pdf Objective: The classroom is an ideal environment to enhance the learning experience by the use of alternative media. In this paper we aimed to inspire a class discussion on the famous television series “Breaking bad”, with the scope to analyze, interpreter and possibly explain all the chemical reactions and the bioactive toxic substances used during the episodes. Methods: We have found three main topics present in the series: i) methamphetamine preparation and its pharmacological effects, ii) ex Drugs, Pharmaceuticals, Hazards, Organic chemistry, Chirality, Multimediabased learning https://www.ijper.org/article/52/3/456-466 2026-04-13T05:55:13.604546+00:00 The Effects of Sugar Addition and Degree of Roast on the Bioactive Compounds and Antioxidant Activity of Turkish-Style Coffee Brews 2018-06-17 10.5530/ijper.52.3.53 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-456.pdf Introduction: Coffee is one of the most widely consumed beverages by the people all around the world. This study was aimed to evaluate the effect of sugar addition, double effects of sugar addition and roasting degree on the polyphenol content, and antioxidant activity of Turkish-style coffee brews. Materials and Methods: The levels of three phenolic compounds (chlorogenic acid, caffeic acid, sinapic acid) and caffeine by reversed-phase high performance liquid chromatography (HPLC) method, as we Antioxidant, Coffee, Degree of roast, Sugar addition, Phenolic compounds https://www.ijper.org/article/52/3/480-491 2026-04-20T05:43:44.511374+00:00 Anti-Leishmanial Activity of Flavanone Analogues Targeting Pteridine Reductase 2018-06-17 10.5530/ijper.52.3.56 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-480.pdf Objectives: The aim of the study is to develop new synthetic anti-leishmanial agents as flavanone analogues, which should have low toxicity with noticeable yield. Methodology: The starting materials for the synthesis of test compounds were 2’-hydroxypropiohenones, 2’-hydroxyacetophenone and substituted benzaldehyde. Test compounds were synthesized by three steps reaction starting from condensation, cyclization and reduction to yield 3-substituted flananone analogues. The synthesized compounds we Antileishmanial activity, Cobalt (II)phthalocyanine, Flavanone derivatives, L. donovani, Promastigotes https://www.ijper.org/article/52/3/381-388 2026-04-13T05:55:13.604546+00:00 Identification of Anticancer Lead Molecules against PRR11 Protein Target with Combination of Protein Modelling Through Threading Approach, Structure Based Chemical Screening of ZINC Database and Pharmacokinetic Properties 2018-06-17 10.5530/ijper.52.3.44 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-381.pdf PRR11 is a cell cycle regulator involved in pathogenesis of cancer. Therapeutically it has been identified as target to inhibit cancer growth. In this study, we employed in silico strategies for determining 3D structure of PRR11 and identification of lead molecules. Molecular modelling of PRR11 was carried out with the help of @TOME2, modeller 9.10 and ModLoop, further structure refinement conceded with SAVES server. ZINC database was virtually screened against reference marine natural compound PRR11, ZINC Database, Threading, Docking, Pharmacokinetics https://www.ijper.org/article/52/3/426-436 2026-04-13T05:55:13.604546+00:00 Antioxidant and Antiurolithiatic Efficacy of Aerva lanata (L) Fractions by in vitro and in vivo Screening Techniques 2018-06-17 10.5530/ijper.52.3.49 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-426.pdf Background: Aerva lanata (L) Juss. Ex. Schult. (Amaranthaceae) commonly known as Pashanabheda is used traditionally in Indian system of medicines for various diseases including urolithiasis. Objective: Screening of bioactivity guided fractions of Aerva lanata (L) for antioxidant and antiurolithiatic potency. Materials and Method: The dried hydro alcoholic extract (10%) of the whole plant was fractionated with different organic solvents like dichloromethane (fraction I), ethyl acetate (fraction I Pashanabheda, Ethylene glycol, Calcium oxalate, Antiurolithiatic activity, Antioxidant activity https://www.ijper.org/article/52/3/437-441 2026-04-20T05:38:42.054467+00:00 Phenolic Contents, Oxidant/Antioxidant Potential and Heavy Metal Levels in Cyclocybe cylindracea 2018-06-17 10.5530/ijper.52.3.50 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-437.pdf Introduction: Mushroom species have been used for medical purposes and as nutrients since the old times. The present study aimed to determine phenolic content, antioxidant activity and heavy metal content of Cyclocybe cylindracea (DC.) Vizzini & Angelini mushroom. Materials and Methods: Phenolic contents were screened with HPLC devices. TAS, TOS and OSI values were determined using Rel Assay kits. Heavy metal content were determined with atomic absorption method using an atomic absorption spectr Cyclocybe cylindracea, Antioxidant, Oxidant, Oxidative stress, Heavy metal, Phenolic contents https://www.ijper.org/article/52/3/374-380 2026-04-13T05:55:13.604546+00:00 Development of pH Independent Drug Release System for Dipyridamole 2018-06-17 10.5530/ijper.52.3.43 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-3-374.pdf Introduction: Dipyridamole is an Anti-platelet agent exhibits release problems at higher pH of small intestine due to its pH dependent solubility and precipitation followed by interruption of drug release from dosage form. To overcome this extended release formulation was developed by using pH modulating agent (tartaric acid). Objective: Present study was undertaken with a view of the formulations evaluated by performing dissolution testing on developed extended released tablets. Method: develop Tartaric acid, Dissolution media, Extended release Dipyridamole Tablets https://www.ijper.org/article/52/2/230-240 2026-04-13T05:55:14.442538+00:00 Formulation and in-vitro drug Released Mechanism of CNS Acting Venlafaxine Nanostructured Lipid Carrier for Major Depressive Disorder 2018-01-28 10.5530/ijper.52.2.26 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-2-230.pdf Venlafaxine (VLX) is a first line, dual acting and unique antidepressant drug which belong to the class of serotonin and norepinephrine reuptake inhibitors. Oral administration of VLX has many adverse effects, poor bioavailability due first-pass hepatic metabolism and low permeability shows poor antidepressant action in the brain. The aim of this present study was to formulate Venlafaxine Nanostructured lipid carrier (VLX-NLC) and deliver directly into the brain through intranasal route. VL Venlofexine, Nanostructured lipid carrier, Antidepressant https://www.ijper.org/article/52/2/327-333 2026-04-20T05:30:47.727682+00:00 Hibiscus plantinifolius Ameliorates Renal Oxidative Damage Induced by Gentamicin in Rats: By Targeting Membrane Bound enzymes 2018-01-28 10.5530/ijper.52.2.38 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-2-327.pdf Objective: Present study evaluates the effect of Hibiscus plantinifolius leaves on kidney function in rats using gentamicin-induced nephrotoxic animal model. Material and Methods: Hibiscus plantinifolius leaves powder was extracted with 95% methanol and performed phytochemical screening. Antioxidant activity was determined by Superoxide anion scavenging, Hydrogen peroxide-scavenging, 1, 1-Diphenyl-2-picrylhydrazyl radical scavenging activity, Fe2+ascorbate induced lipid peroxidation methods. Acu Methanolic extract of Hibiscus plantinifolius (MEHP), Gentamicin, Membrane, bound enzymes, Antioxidants https://www.ijper.org/article/52/2/218-229 2026-04-20T05:20:39.147591+00:00 Factorial Design Methodology for Development of Pediatric Nasal Spray: Study on Xylometazoline Nasal Solution Used For Treatment of Nasal Congestion 2018-01-28 10.5530/ijper.52.2.25 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-2-218.pdf Objective:The objective of the present work is to develop the meter dose pediatric formulation of xylometazoline hydrochloride for enhanced effectiveness for nasal decongestion. Experimental Work: The 32 factorial experimental design was employed for optimization of sodium cholate (X1) and Polyethyleneglycol 400 concentration (X2) in the formulation. The optimized formulation contains 1.18 % w/v sodium cholate and 13 % v/v Polyethyleneglycol 400. The formulation was further evaluated for its dru Nasal congestion, Factorial design, Meter dose formulation, Xylometazoline, hydrochloride, Sodium cholate https://www.ijper.org/article/52/2/248-254 2026-04-13T05:55:14.442538+00:00 Evaluation of Diuretic and Saliuretic Potential of Beta vulgaris (Beet Root) at Different Doses 2018-01-28 10.5530/ijper.52.2.28 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-2-248.pdf Background: Natural foods are presently being evaluated for their pharmacological activity. They are comparatively safer and possess fewer adverse effects. Objective: The current study was designed to evaluate the diuretic effect of different doses of lyophilized Beta vulgaris. Methodology: Aqueous solution of Beta vulgaris at doses of (500 mg/kg and 1000 mg/kg) was administered to rats. Furosemide 40 mg/70kg and distilled water were used as standard and control respectively. Metabolic cag Chloride, Diuretics, Metabolic cage, Phosphorus, Potassium and Sodium https://www.ijper.org/article/52/2/277-283 2026-04-13T05:55:14.442538+00:00 Biological Activities of Endophytic Fungus Cochliobolus sp.AL24 Isolated from Aerva lanata. L 2018-01-28 10.5530/ijper.52.2.32 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-2-277.pdf Background: The plant Aerva lanata L belongs to the family Amaranthaceae and traditionally used in the treatment of rheumatism, kidney stones and malaria. In the present study endophytic fungus was isolated from A.lanata and screened of various extracts in vitro for their pharmacological potentials. Objective: To evaluate the antioxidant, antidiabetic and anti-inflammatory potentials of various extracts of endophytic fungus Cochliobolus sp from A. lanata. Materials and Methods: The fungus w Aerva lanata, Endophyte fungus, Antidiabetic, Anti-inflammatory, Antioxidant https://www.ijper.org/article/52/2/321-326 2026-04-13T05:55:14.442538+00:00 Estimation of Phenolic Compounds Present in the Plant Extracts Using High Pressure Liquid Chromatography, Antioxidant Properties and its Antibacterial Activity 2018-01-28 10.5530/ijper.52.2.37 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-2-321.pdf Objective: The aim of the present study was to evaluate total phenolic content of the prepared plant extracts and investigation of phenolic compounds present in the extract. Background: The method was done to evaluate the phenolic compounds and finding the components presence. Methods: The extraction was carried out using methanol as the solvent. Plants used in this analysis were Acalypha indica, Azadirachta indica, Lawsonia inermis and Murraya konegii. Qualitative estimation of total phen HPLC, Folin- Ciocalteu, Extraction, Simple phenols, Catechins https://www.ijper.org/article/52/2/197-201 2026-04-20T05:18:22.445083+00:00 Self-Esteem Level and Its Relationship to Academic Performance among Undergraduate Pharmacy Students in a Malaysian Public University 2018-01-28 10.5530/ijper.52.2.21 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-2-197.pdf Objectives: To assess self-esteem level among undergraduate pharmacy students, to determine the demographic variables that could have significantly influenced the self esteem level and to determine the correlation between the self-esteem level and academic performance. Methods: A 10-item Rosenberg Self-Esteem Scale (RSES) together with demographics section (e.g. age, gender, year of study, marital status, residency, highest achieved qualification), was distributed to all year 1 to year 4 pha Academic Performance, Pharmacy, Self-Esteem, Below:CGPA, Undergraduate https://www.ijper.org/article/52/2/262-267 2026-04-20T05:25:14.178279+00:00 Antitumor Activity of Methanolic Fractions Extracted From the Aerial Part of Algerian Hyoscyamus albus and apoptotic cell aspect screening 2018-01-28 10.5530/ijper.52.2.30 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-2-262.pdf Hyoscyamus albus is a plant which belongs to the Solanaceae family, used generally in traditional medicine as a nervous sedative and para sympatholytic which is a rich source of flavonoid, alkaloids and tropane. The present work is for an object to test the methanolic fractions extracted from the aerial parts of H.albus collected among the Aures region in Algeria, and evaluate their cytotoxic activity on different cancer cells lines with the characterization of microscopically morphology of apop Hyoscyamus albus L, Solanaceae, Acridine, Cytotoxic Activity, Fraction https://www.ijper.org/article/52/2/255-261 2026-04-13T05:55:14.442538+00:00 Biologically Active Metal Complexes Containing Thiazole core: Synthesis and Spectral Characterization 2018-01-28 10.5530/ijper.52.2.29 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-2-255.pdf The present study deals with the synthesis of new ligand N-(4-phenylthiazol-2-yl)-2 (pyridin-2-yl-methylene) hydrazinecarboxamide and it’s Cu (II), Co (II), Ni (II) and Zn (II) complexes and study their antimicrobial activity. The newly prepared compounds are characterized by elemental analysis, FT-IR, 1H NMR, mass, UV-visible and ESR spectral techniques. The elemental analysis data and spectral study indicates octahedral geometry for Cu (II), Co (II) and Ni (II) complexes and tetrahedral ge Schiff base, Thiazole, Pyridine-2-carboxaldehyde, Antimicrobial https://www.ijper.org/article/52/2/181-196 2026-04-13T05:55:14.442538+00:00 Economic Aspects, Economic Assessment and Career Preferences of Doctor of Pharmacy (PharmD) Students in India 2018-01-28 10.5530/ijper.52.2.20 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-2-181.pdf Background: PharmD study program is newer in India. There is tremendous scope for this study program in the country but it will take more time for PharmD to get well developed as a firm career option for the current and prospective students. Therefore, we aimed to determine the economic aspects of the Indian PharmD students. We also conducted the cost benefit analysis of the study program and analyzed the career preferences of the students. Methods: A 30-item questionnaire was developed, va PharmD, India, Economics, Cost benefit analysis, Students, Pharmacy https://www.ijper.org/article/52/2/311-320 2026-04-13T05:55:14.442538+00:00 Predictors of Burnout Syndrome among Professionals in the Pharmaceutical Industry in the Republic of Serbia 2018-01-28 10.5530/ijper.52.2.36 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-2-311.pdf Objective: The aim of the research was to determine the frequency and severity of the burnout syndrome among the university educated professionals, working in pharmaceutical companies, related to burnout categories and to determine the connection between this concept and assertiveness. Method: The research was conducted by a cross-sectional study, on a suitable appropriate sample during 2016, and it included 75 university educated professionals, working in pharmaceutical industry in Serbia. Burnout syndrome, Assertiveness, Pharmacists, Pharmaceutical Companies, Marketing, Drug manufacturing https://www.ijper.org/article/52/2/207-211 2026-04-13T05:55:14.442538+00:00 Social Media: A Double Edged Sword for Accessing Health Care Information 2018-01-28 10.5530/ijper.52.2.23 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-2-207.pdf Technology has improved speed and ease of communication using various platforms. Recent improvements in technology using Social Media (SM) has dramatically changed the way communication happens. Success stories of Facebook, Twitter, LinkedIn, WhatsApp, blog sites are some examples of how different media are used by people to communicate using digital technology and social media. Access to information, including healthcare, using SM is on the rise owing to its ease and accessibility. Since p Social media, Healthcare, Regulation https://www.ijper.org/article/52/2/305-310 2026-04-13T05:55:14.442538+00:00 Impact of Patient Counselling on The Knowledge, Attitude, Practice and Quality of Life in Patients with Hypertension with Diabetes Mellitus-II 2018-01-28 10.5530/ijper.52.2.35 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-2-305.pdf Context: The most important role of patient counselling is to improve quality of life and provide quality care for patients. The occurrence of drug related problems such as adverse effects, side effects, drug interactions and errors in use of medication can be minimised. Aims: The main aim of this study was to assess the impact of pharmacist provided patient counselling on treatment outcomes and quality of life (QOL) in hypertensive and diabetes mellitus type-II patients, improving their kn Quality of Life, Hypertension, Diabetes Mellitus, Patient Counselling, Type, II Diabetes https://www.ijper.org/article/52/2/212-217 2026-04-13T05:55:14.442538+00:00 Technological and Biopharmaceutical Characterization of Carbopol-Based Ketoprofen Emulgels 2018-01-28 10.5530/ijper.52.2.24 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-2-212.pdf Objective: Emulgels are a combination of emulsions and gels. In this study, the influence of different oil phases and gelling agent concentrations on the technological and biopharmaceutical characteristics of prepared emulgels is assessed. Materials and Methods: Light liquid paraffin (various concentrations), cetyl alcohol, isopropyl myristate, and almond oil were used in the oil phase of the emulsions, and Carbopol® 940 (0.5%, 0.75%, and 1% w/w concentrations) was used as the gelling agent Carbopol, Emulgels, Ketoprofen, Topical application https://www.ijper.org/article/52/2/293-304 2026-04-13T05:55:14.442538+00:00 Chemometric Assisted Ion-Pair Chromatography of Metaxolone and Diclofenac in Binary Mixture: A Mechanistic Study 2018-01-28 10.5530/ijper.52.2.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-2-293.pdf A reversed-phase high-performance liquid chromatographic (RP-HPLC) method based on ion pair formation is demonstrated for the simultaneous determination of Metaxalone (MTX) and Diclofenac potassium (DCP) in commercial formulations. MTX (pKa=12.24) and DCP (pKa=4.00) are hydrophilic ionic substances that make the separation critical due to distinct pKa values. Addition of ionic additives (ion-pairing reagents or chaotropic agents) to the mobile phase allowed a significant improvement in rete Amphiphilicity, Chemometrics, Diclofenac, Ion-Pair formation, Metaxalone, RP-HPLC https://www.ijper.org/article/52/2/268-276 2026-04-13T05:55:14.442538+00:00 Histopathological Impact in the Larval Gut of the Honeybee, Apis mellifera jemenitica, Upon Infection with the American Foulbrood Bacterium, Paenibacillus larvae 2018-01-28 10.5530/ijper.52.2.31 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-2-268.pdf Background: American foulbrood (AFB), caused by Paenibacillus larvae (P.larvae) bacterium, is one of the major threatening disease to the global apiculture industry. This Apiary-threatening bacterium has recently been detected in some of the Saudi Apiaries. The current study herein was conducted to investigate the impact of the locally isolated P. larvae infection on the histological integrity of the alimentary tract of the indigenous Saudi honeybee brood, Apis mellifera jemenitica (A.mel Histopatology, P.larvae, A.mellifera jemenitica, Saudi apiaries https://www.ijper.org/article/52/2/241-247 2026-04-20T05:22:20.515502+00:00 Evaluation of Clerodendrum inerme (L.) Gaertn. on Burkitt’s Lymphoma Cancer 2018-01-28 10.5530/ijper.52.2.27 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-2-241.pdf According to current census every year six million deaths occur in the world due to cancer. Hence, there is need of discovery and development of novel, safe and efficacious drugs for the treatment of various cancer. In the present study, an attempt has been made to explore the medicinal aspects of Clerodendrum inerme (L.) Gaertn.. Verbenaceae plant involving cytotoxic and antiproliferative potential as hydroalcoholic extract using methanol and water (70:30 V/V). Preliminary phytochemical investi Clerodendrum inerme, Cytotoxicity, Antiproliferative, Lethality, MTT, Daudi https://www.ijper.org/article/52/2/284-292 2026-04-13T05:55:14.442538+00:00 Comparison of Mean Centering of Ratio Spectra Based Spectrophotometric Approach and HPLC Method for Quantitative Determination of Pirenoxine in the Presence of Methylparaben and Propylparaben 2018-01-28 10.5530/ijper.52.2.33 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-2-284.pdf Objective: The mean centering of ratio spectra method (MCR) was developed for determination of pirenoxine in the presence of methylparaben and propylparaben. Background: The UV spectrum of pirenoxine was suffered from spectra overlapping of methylparaben and propylparaben, the preservatives used in the eye drop formulation. Since, MCR method was introduced to overcome this limitation. Methods: The developed MCR method was performed using 39 synthetic mixtures of pirenoxine, methylparaben a Pirenoxine, Mean centering of ratio spectra, HPLC https://www.ijper.org/article/52/2/202-206 2026-04-13T05:55:14.442538+00:00 Is there a Role for Pharmacist in Safety Monitoring of Vaccines? 2018-01-28 10.5530/ijper.52.2.22 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-2-202.pdf India has approximately 7.4 million unimmunized children and responsible for more than five lakhs deaths annually. News about Adverse Events Following Immunizations (AEFIs) is one of the important barriers in India to lag behind in vaccination coverage along with lack of awareness and cultural diversity of parents. The expectation from vaccines are very high unlike drugs and any reports on adverse vaccine events may damage the public confidence in vaccination program. As an important member Pharmacist, Safety monitoring, Vaccine pharmacovigilance, Causality, Assessment https://www.ijper.org/article/52/1/1-9 2026-04-13T05:55:15.14109+00:00 Revisiting Concepts, Attitudes and Expectations of Brazilian Pharmacists to the Practice of Pharmaceutical Care: A Qualitative Perspective 2018-01-02 10.5530/ijper.52.1.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-1-1.pdf Background: Research has shown advancements in pharmaceutical care services to the population, with a change in practitioners’ professional behaviors. Objective: This study aimed to assess present attitudes, expectations and associated meanings facing these pharmacists’ extended role in primary care. Methods: The study followed a qualitative design. Data collection was carried out between 2011 and 2012, in two stages: the first used semi-structured individual interviews; the second one followed Pharmaceutical Services, Pharmaceutical Care, Primary Health Care, Qualitative Research, Brazil https://www.ijper.org/article/52/1/42-53 2026-04-13T05:55:15.14109+00:00 Pharmacokinetics and Tissue Distribution of PLGAPLL-PEG-TF Nanoparticles Loaded with Daunorubicin and Tetrandrine Following Intravenous Injection in the Rats Using LC-MS/MS 2018-01-02 10.5530/ijper.52.1.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-1-42.pdf Objective: A sensitive, rapid and reliable LC-MS/MS method was developed for simultaneously determination of daunorubicin (DNR) and tetrandrine (Tet) in rat plasma and tissues. Methods: The pharmacokinetics and tissue distribution of DNR/Tet-PLGAPLL-PEG-NPs-Tf (D/T-PPP-NPs-Tf), DNR/Tet-PLGA-PLL-PEG-NPs (D/T-PPP-NPs) and DNR/Tet (D/T) solution were compared following intravenous injection in the rats. Result: Compare to D/T solution, the parameters of DNR and Tet in D/T-PPP-NPs-Tf group presented Nanoparticles, Daunorubicin, Tetrandrine, Pharmacokinetics, Tissue, Distribution https://www.ijper.org/article/52/1/101-109 2026-04-20T05:09:09.753788+00:00 Protective Effect of A2B Receptor Antagonist (TRP 1) on Acetic Acid Induced Ulcerative Colitis in Rats: in vitro, in vivo and in silico Methods 2018-01-02 10.5530/ijper.52.1.12 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-1-101.pdf Aim: Present study was elucidate the protective effect of pyridinone derivatives such as 7-amino-5-oxo-2- Phenyl-5H, 8H-dihydro-[1, 2, 4] triazolo [1, 5-α] pyridine - 6- carbonitril (TRP 1) by in vitro, in vivo and in silico. Methods: Radioligand binding assay was performed on human adenosine receptors (A2B) and assess A2B antagonist effect by adenylyl cyclase activity. In vitro study was carried out to determine the neutralize capacity against DPPH*, NO*, SO*, LPO* free radicals. TRP 1 at the d 7-amino-5-oxo-2- phenyl)-5H, 8H-dihydro-[1, 2, 4] triazolo [1, 5-α] pyridine - 6-, carbonitril (TRP 1), Ulcerative colitis, Acetic acid, Myeloperoxydase (MPO), Glutathione, (GSH), Catalase, TNF α, IL 1β and IL 6 https://www.ijper.org/article/52/1/166-180 2026-04-20T05:13:39.899557+00:00 Cultural Adaptation and Examination of Metric Characteristics Shirom-Melamed Burnout Questionnaire (SMBQ) On a Sample of Pharmacists in Serbia 2018-01-02 10.5530/ijper.52.1.19 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-1-166.pdf Introduction: Due to the nature of work in pharmacies pharmacists may occur job burnout, which can affect the quality of health services. It is necessary to use validated instruments to test the burnout. One type of instrument is Shirom-Melamed Burnout Questionnaire (SMBQ). Objective: The primary objectives of this work are: cultural adaptation and assessment metric characteristics of SMBQ in a population of pharmacists in Serbia. Alternative objective is evaluate the degree of burnout in the ph Shirom-Melamed Burnout Questionnaire, Cultural Adaptation, Metric, Characteristics. Job Burnout, Pharmacists, Serbia https://www.ijper.org/article/52/1/159-165 2026-04-13T05:55:15.14109+00:00 Comparative Shape and Electrostatic Study of Highly Potent and Selective CYP1B1 Inhibitor: Assessment of Active Site of CYP1B1 by Binding Mode Analysis Using Site Map Tool 2018-01-02 10.5530/ijper.52.1.18 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-1-159.pdf Introduction: The major aim of drug design and discovery is to minimize the time and cost of drug discovery process. Various molecules which are promised to be potential candidate during computational and preclinical studies, shows the poor results during clinical trials due to less credibility of in silico results. This leads to increased burden of time and cost of drug discovery process. Methodology: A reliabel Shape and Electrostatic similarity based screening of ligands and assessment of dru CYP1B1, Shape electrostatic coefficient, Sitemap analysis, Druggability, In silico ADME calculation https://www.ijper.org/article/52/1/10-20 2026-04-13T05:55:15.14109+00:00 A Study on the Perceived Gap in Between Industry and Academia with Reference to the Curriculum of Post-Graduate Courses In Pharmaceutical Sciences in india 2018-01-02 10.5530/ijper.52.1.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-1-10.pdf The rapid growth of pharmaceutical industry in India has resulted into an increased demand for skilled and trained graduates and post-graduates in pharmaceutical sciences over the last decade. Over a period of time due to the rapid development and changing technology, academic institutions have not been able to produce pharmacists who are productive and readily employable. Thus, resulting in a gap between industry and academia. Aim: The present study aims to identify the gap which exists in indu Pharmaceutical Education, Post Graduate Courses, Industry- Academia, Linkage, Pharmaceutical Sciences, Proportionality test https://www.ijper.org/article/52/1/78-86 2026-04-20T05:06:38.787246+00:00 Chemo Preventive Effect of Rutin Against N-Nitrosodiethylamine-Induced and PhenobarbitalPromoted Hepatocellular Carcinoma in Wistar Rats 2018-01-02 10.5530/ijper.52.1.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-1-78.pdf Background: In recent years, a large number of natural compounds have been identified and proved to have a potential cancer chemopreventive importance due to their strong antioxidant and cytotoxic activities. Objective: The present study is designed to investigate the preventive effects of Rutin against N-Nitrosodiethylamine-induced and Phenobarbital-promoted Hepatocellular carcinoma in male wistar rats. Materials and Methods: Twenty-four male wistar rats were divided into four groups (n=6). Gro Hepatocellular Carcinoma, Rutin, N-Nitrosodiethylamine, Phenobarbital, α-fetoprotein, Carcinoembryonic antigen https://www.ijper.org/article/52/1/71-77 2026-04-13T05:55:15.14109+00:00 Solid State Characterization and Tableting Studies of Ethanol Based Cocrystals of Fenofibrate with Nicotinamide 2018-01-02 10.5530/ijper.52.1.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-1-71.pdf Objectives: The pharmaceutical cocrystals can be defined as dissociable “API-excipient” molecular complexes or Co-crystals are solids that are crystalline materials composed of two or more molecules in the same crystal lattice as per U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) April 2013. The objectives of present investigation were to formulate cocrystals of fenofibrate with nicotinamide by solution cocrystallization t Cocrystals, Crystallizaton, Fenofibrate, Nicotinamide, Tableting https://www.ijper.org/article/52/1/151-158 2026-04-13T05:55:15.14109+00:00 Development of Rapid and Validated RP-HPLC Method for Concurrent Quantification of Rosuvastatin and Aspirin form Solid Dosage Form 2018-01-02 10.5530/ijper.52.1.17 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-1-151.pdf Background: Combination of aspirin and rosuvastatin has been successfully used for the treatment of hyperlipidemia. Objective: The objective of the project was to establish a rapid, accurate and precise liquid chromatographic method for the concurrent quantification of aspirin and rosuvastatin from solid dosage form. Methodology: The analytes were successfully separated on chromolith C18 monolithic column, using 20mM phosphate buffer (pH. 3): acetonitrile: methanol in a proportion of 50:20:30 by RP-HPLC, Simultaneous determination, Rosuvastatin, Aspirin, Monolithic, column https://www.ijper.org/article/52/1/62-70 2026-04-13T05:55:15.14109+00:00 Development and Evaluation of High Oxaliplatin Loaded CS-g-PNIPAAm Co-Polymeric Nanoparticles for Thermo and pH Responsive Delivery 2018-01-02 10.5530/ijper.52.1.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-1-62.pdf Background: Chitosan-g-poly(N-isopropylacrylamide) (CS-g-PNIPAAm) co-polymer was reported as a much efficient drug carrier but it shows very low percentage of drug loading in to the nanoparticles. Objective: The objective of the present study was to develop highly loaded pH and thermo responsive CS-g-PNIPAAm co-polymeric nanoparticles for tumor specific oxaliplatin delivery. Methods: CS-g-PNIPAAm co-polymer was synthesized by surfactant free dispersion copolymerization method and characterized f Oxaliplatin, Chitosan-g-poly(N-isopropylacrylamide), Self assembly method, Thermo and pH responsive delivery https://www.ijper.org/article/52/1/146-150 2026-04-13T05:55:15.14109+00:00 The Effect of Aminophylline on Quinidine Passage into the Central Nervous System of Rats 2018-01-02 10.5530/ijper.52.1.16 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-1-146.pdf Background and Objective: There is significant interest in mutual influence of substances during their passage into the central nervous system (CNS). Quinidine is a drug which can achieve significant concentration in CNS and cause side effects and aminophylline is a drug with possibility to change distribution of drugs in CNS. Thus the aim of this work was to study the effect of aminophylline on the transition of quinidine through the bloodbrain barrier into the central nervous system. Material Aminophylline, Quinidine, Blood-brain barrier, Drug interactions https://www.ijper.org/article/52/1/122-134 2026-04-13T05:55:15.14109+00:00 Novel Potent Inhibitors of Plasmodium vivax Dihydrofolate Reductase: An in silico Antimalarial Drug Discovery 2018-01-02 10.5530/ijper.52.1.14 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-1-122.pdf Objectives: In the present study, we targeted the dihydrofolate reductase enzyme that catalyzes the reduction of dihydrofolate to tetrahydrofolate which is required for the purines and pyrimidine synthesis. Malaria is one of the severe diseases throughout the world caused by blood-borne parasite Plasmodium vivax. Materials and Methods: Eightyfive parthenin analogs were docked against P. vivax and Homo sapiens dihydrofolate reductase proteins (PDB 2BL9 and 1KMS respectively) by using Maestro 9.6 Dihydrofolate reductase (DHFR), Malaria, Parthenin analogs (like compounds), Maestro 9.6, Antimalarial Drugs https://www.ijper.org/article/52/1/94-100 2026-04-13T05:55:15.14109+00:00 Antioxidant Properties and Protective Effect of Turkish Propolis on t-BHP-Induced Oxidative Stress in Foreskin Fibroblast Cells 2018-01-02 10.5530/ijper.52.1.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-1-94.pdf Objective: Propolis is an important bee product, rich in polyphenolic compounds. It has antitumoral, antioxidant, antimutagenic, and other useful activities. Biological activities of propolis are generally attributed to its substance of polyphenolic compounds. The aim of this study was to investigate the in vitro antioxidant properties and reduction amount of intracellular reactive oxygen species (ROS) in human normal foreskin fibroblast cells by Turkish propolis ethanolic extract (EEP). Method: Antioxidant activity, CM-H2DCFDA, Fibroblast cells, Polyphenols, Propolis https://www.ijper.org/article/52/1/54-61 2026-04-13T05:55:15.14109+00:00 Pharmaceutical Formulation and Biochemical Evaluation of Atorvastatin Transdermal Patches 2018-01-02 10.5530/ijper.52.1.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-1-54.pdf Atorvastatin is a lipid lowering agent and widely used to treat hypercholestermia. However following oral administration, the bioavailability of the drug is only 12% due to extensive first pass metabolism. The aim of the current research was to formulate ATO- transdermal patches utilizing various polymers combinations. Hydroxypropyl methylcellulose with either eudragit RS100 or Polyvinylpyrrolidone were mixed in different ratios, in presence of polyethylene glycol 400 as plasticizer. The patches Atorvastatin, Patches, Polymers, FTIR, DSC, Hyperlipidemia https://www.ijper.org/article/52/1/32-41 2026-04-13T05:55:15.14109+00:00 Curcumin: The Molecular Mechanisms of Action in Inflammation and Cell Death during Kainate-Induced Epileptogenesis 2018-01-02 10.5530/ijper.52.1.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-1-32.pdf Background: Recent preclinical studies demonstrated the potential antiepileptogenic effect of curcumin. Its molecular pathways in modulating epileptogenesis remain unclear. Objectives: This study investigated the epileptogenic processes induced by kainic acid (KA) and to investigate the antiepileptogenic pathways associated with curcumin therapy. Methods: A single dose of KA 10 mg/kg was used to induce a convulsive status epilepticus in female Wistar rats. After one week of curcumin treatment, g Epileptogenesis, Curcumin, Kainic acid, Gene expression, Anti-epileptogenic, Temporal lobe epilepsy https://www.ijper.org/article/52/1/21-31 2026-04-13T05:55:15.14109+00:00 Research Involvement of Pharmacy Faculties in India 2018-01-02 10.5530/ijper.52.1.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-1-21.pdf Objective: The contribution of Indian pharmacy research is unremarkable in the world. Hence, we aimed to determine the research involvement and research productivity of Indian pharmacy faculties. Methods: A questionnaire evaluating research involvement and research productivity of the faculties was developed, validated and sent to 7536 email addresses. The main question categories in the questionnaire were- demographics, journal related research activities, conference related research activities Pharmacy Education, India, Pharmacy, Faculty research, Academic research, Research involvement https://www.ijper.org/article/52/1/135-145 2026-04-13T05:55:15.14109+00:00 Synthesis and Characterization of 2-phenyl-5- (1-phenyl-3-(3, 4, 5-trimethoxyphenyl)-1H-pyrazol4-yl) - 1, 3, 4-oxadiazole Scaffolds for Assessing Their Medicinal Potentials 2018-01-02 10.5530/ijper.52.1.15 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-1-135.pdf Objective: The present research is aimed at the discovery and development of 1-phenyl-3- (3,4,5-trimethoxyphenyl)-1H-pyrazole derivatives as a series of novel 1, 3, 4-oxadiazoles (7a-7h) through iodine-catalyzed oxidative cyclization of the hydrazone derivatives (6a6h) in the presence of potassium carbonate as base and DMSO as solvent in good toexcellent yields. Methods: The structures of all the newly synthesized compounds (6a6h) and(7a-7h) were well characterized by IR, 1H NMR, 13C NMR and HRM Hydrazones, Oxadiazoles, Pyrazole, Anti-microbial, Anti-oxidant activity https://www.ijper.org/article/52/1/110-121 2026-04-13T05:55:15.14109+00:00 Synthesis, Characterization, Antidepressant Activity and Docking Studies of Some Novel Indole Bearing Azetidinone Derivatives 2018-01-02 10.5530/ijper.52.1.13 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-1-110.pdf Context: In general, indole bearing azetidinone derivatives are exhibiting various biological activities. The evaluation of pharmacological potential of the indole bearing azetidinone derivatives as antidepressant agent has been relatively less explored. To get insight of the intermolecular interactions, the molecular docking studies are performed at active site of MAO-A enzyme. Aim: In this study, an attempt has been made to generate new molecular template by linking two pharmacophores (indole Indole, Azetidinone, Antidepressant activity, Docking study https://www.ijper.org/article/52/1/87-93 2026-04-13T05:55:15.14109+00:00 Effect of Canscora decussata Extract against the Neurochemical and Behavioral Changes Induced by 1-Methyl-4-Phenyl-1, 2, 3, 6-Tetrahydropyridine in Mice 2018-01-02 10.5530/ijper.52.1.10 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-52-1-87.pdf Objective:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced parkinsonism is a widely accepted animal model for screening the drugs used in Parkinson’s disease (PD). In the present study, the neuroprotective effects of methanolic extract of Canscora decussata (MECD) were evaluated, which was already known for its monoamine oxidase inhibiting, antidepressant and anticonvulsant activities, a part from its use as a nerve tonic. Materials and Methods: Twenty four male Swiss albino mice were Parkinson’s disease, Canscora decussata, Substantia nigra, Dopamine https://www.ijper.org/article/51/4s/s675-s678 2026-04-17T11:51:40.35986+00:00 Use of the Herbal OTC Products and Dietary Supplements by Patients Receiving Chemotherapy: Survey-Based Study 2017-12-25 10.5530/ijper.51.4s.98 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-675.pdf Context: Among cancer patients receiving chemotherapy, there is a growing trend to use self-medication. Many of them take preparations sold over the counter (OTC) and dietary supplements containing plant raw materials. Aims: The aim of this study is to evaluate the herbal OTC drug and dietary supplement usage among patients treated on the chemotherapy ward. Settings and Design: An anonymous survey was conducted among 92 patients of the chemotherapy ward of the Lower Silesian Oncology Center in W Herbal OTC products, Dietary supplements, Chemotherapy, Self-medication https://www.ijper.org/article/51/4s/s747-s753 2026-04-17T11:56:00.612621+00:00 Investigation of in vitro Antioxidant and Anti-inflammatory Activities of Selected Siddha Polyherbal Formulations 2017-12-25 10.5530/ijper.51.4s.108 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-747.pdf Objective: This study deals with the antioxidant and anti-inflammatory activities of selected Siddha polyherbal formulations such as Amukkara choornam, Thirikadugu choornam, Eladi choornam and Thiripala choornam. Amukkara choornam consist of seven herbals (withania, ginger, black pepper, long pepper, mesua, cardamom and clove). Thirikadugu choornam has three herbal ingredients ginger, black pepper and long pepper. Eladi choornam has seven raw drugs like cardamom, ginger, arrow root, yew leaves, Aqueous extract, Polyphenols, Antioxidant, Anti-inflammatory, Amukkara, choornam, Thirikadugu choornam, Eladi choornam, Thiripala choornam https://www.ijper.org/article/51/4s/s548-s558 2026-04-17T11:36:00.453861+00:00 Process Optimization of Methylphenidate Hydrochloride Extended Release Pellets by QbD 2017-12-25 10.5530/ijper.51.4s.82 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-548.pdf Objective: The aim of the present research work was to optimize the process of Methylphenidate Hydrochloride (HCl) Extended releasse (ER) pellets based on Quality by Design (QbD) principles. Materials and methods: Wurster (Bottom spray fluid bed coating) process was employed to develop ER pellets of Methylphenidate HCl. Impact of various process variables on drug layering process was assessed by using statistical interpretation such as ANOVA. A face centered central composite design (CCD) was em Methylphenidate HCl, Pellets, Central composite design, Process variables https://www.ijper.org/article/51/4s/s566-s570 2026-04-17T11:37:45.082665+00:00 Enhancement of Paclitaxel Oral Bioavailability in Swiss Mice by Four Consecutive Days of Pre-Treatment with Curcumin 2017-12-25 10.5530/ijper.51.4s.84 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-566.pdf Objective: Poor water solubility, P-glycoprotein (P-gp) efflux property and substrate of CYP3A lead to low oral bioavailability that limit the oral use of paclitaxel, a key anticancer drug. Though several formulation approaches were tried to combat this low absorption profile but effect of pre-treatment with curcumin, a naturally occurring CYP3A and P-gp inhibitor on augmentation of paclitaxel plasma level is not reported till now. Therefore, the objective of the present study is to asses any ch Paclitaxel, Curcumin, HPLC, Plasma, Pre-treatment, Bioavailability https://www.ijper.org/article/51/4s/s631-s636 2026-04-17T11:44:46.96042+00:00 The Optimum Extraction Process for Radix glycyrrhizae and Angelica dahurica (Fisch.) Benth.et Hook with Orthogonal Design 2017-12-25 10.5530/ijper.51.4s.92 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-631.pdf Background: To develop the optimal extractive technique of the Radix glycyrrhizae and Angelica dahurica (Fisch.) Benth.et Hook in the Fengshiding dropping pill. Methods: Single factor experiments were carried out on the effect of water-ethanol extraction by the multiple guidelines grading of the dried extract quantity, the contents of liquiritin and imperatorin. Furthermore, orthogonal experimental design was used for the optimization of cross-functional process. The dried extract quantity and t Radix glycyrrhizae, Angelica dahurica (Fisch.) Benth.et Hook, Liquiritin, Imperatorin, Orthogonal test https://www.ijper.org/article/51/4s/s761-s768 2026-04-17T11:56:42.486797+00:00 The Development and Validation of Stability Indicating Analytical Method for Determination of Nortriptyline in Nortriptyline HCl Tablets by Liquid Chromatography 2017-12-25 10.5530/ijper.51.4s.110 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-761.pdf Purpose: To develop and validate a rapid, rugged, precise and an accurate stability indicating analytical method for determination of Nortriptyline HCl in Nortriptyline tablets. The separation of impurities and Nortriptyline HCl drug was achieved by an isocratic liquid chromatographic method using Inertsil, C18, 250 mm x 4.6 mm, 5μm column at 45ºC. The mobile phase consists of 70% Methanol and 30% phosphate buffer of pH-7.5 pumped at a flow rate of 1.0 ml/min. The detection was carried out at a Nortriptyline HCl, Impurity, Liquid chromatography, Forced degradation, Stability indicating https://www.ijper.org/article/51/4s/s607-s614 2026-04-13T05:55:15.893084+00:00 Evaluation of Antiurolithiatic Potentials of Hydro-Alcoholic Extract of Cucumis sativus L. 2017-12-25 10.5530/ijper.51.4s.89 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-607.pdf Introduction: Cucumis sativus fruits are claimed for their antiurolithiatic activity in traditional system of medicine. Materials and Methods: Present study was undertaken to evaluate lithotryptic effect using hydro-alcoholic extract of Cucumis sativus (HCS). Ethylene glycol (0.75% v/v) was used to induce calculi in Wistar albino rats. Assessed various parameters like, Biochemical, Histopathological and routine urine analysis. Results: Treatment with preventive and curative doses of HCS was foun Cucumis sativus, Antiurolithiatic, Ethylene glycol (0.75 % v/v), Diuretic, Cystone, Kidney stone https://www.ijper.org/article/51/4s/s783-s789 2026-04-20T04:56:48.643074+00:00 Development and Validation of Inductively Coupled Plasma Atomic Emission Spectroscopy [ICP-AES] Analytical Method for Estimation of Cisplatin in Biological Samples 2017-12-25 10.5530/ijper.51.4s.113 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-783.pdf Objective: Cisplatin, a popular anti-neoplastic agent is employed as a first line treatment for variety of cancers. Majority of the analytical methods reported for Cisplatin are either complex or not suitable for routine analysis of the drug. Hence, there is a need for development of suitable analytical technique like ICP-AES for quantitation of Cisplatin in complex matrices and biological samples. Methods: Cisplatin was analyzed in the present study based on its single step conversion to platin Cancer, Cisplatin, ICP-AES, Platinum https://www.ijper.org/article/51/4s/s729-s734 2026-04-13T05:55:15.893084+00:00 A Rapid and Sensitive Bio Analytical RP-HPLC Method for Detection of Docetaxel: Development and Validation 2017-12-25 10.5530/ijper.51.4s.105 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-729.pdf Objective: A rapid and selective high-performance liquid chromatographic (HPLC) method has been developed and validated for Docetaxel anhydrous (DTX) using Ketoconanzole (KCZ) as an internal standard in biological fluids. Methods: The analyte was extracted from human plasma by liquid-liquid extraction method using acetonitrile. The analysis was carried out on Licrosphere IV, C8 column (LC–GC Chromatography Solutions Pvt. Ltd, Mumbai, and India) (4.6×250 mm) with isocratic elution using a mobile Docetaxel anhydrous, Ketoconazole, Bio-analytical method, HPLC, Pharmacokinetic study https://www.ijper.org/article/51/4s/s776-s782 2026-04-17T11:57:44.788898+00:00 Development and Validation of UV-Derivative Spectroscopic and RP-HPLC Methods for the Determination of Amlodipine Besylate and Valsartan in Tablet Dosage form and Comparison of the Developed Methods by Student’s T-Test 2017-12-25 10.5530/ijper.51.4s.112 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-776.pdf Introduction: Hypertension is directly responsible for 51% of all stroke deaths and 45% of all coronary heart diseases worldwide. Amlodipine besylate is a calcium channel blocker used as an anti-hypertensive agent. Valsartan is an angiotensin II receptor blocker used in the treatment of hypertension. Rationale: Fixed-dose combination products are becoming popular because of simplified dosage regimens, enhanced patient adherence and reduced costs. Therefore there is a need for analytical methods Amlodipine, Valsartan, Derivative Spectroscopy, RP-HPLC, T- test, Tablet https://www.ijper.org/article/51/4s/s769-s775 2026-04-17T11:57:12.390291+00:00 Stability Indicating HPLC Method Using Core Shell Stationary Phase for the Determination of Related Substances in Levocetirizine Dihydrochloride Oral Solution 2017-12-25 10.5530/ijper.51.4s.111 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-769.pdf Rationale: Levocetirizine (LCZ) is a new generation antihistamine drug used for the allergic symptoms resulting from various diseases. The present research work focuses on the development of a simple and precise HPLC method for the effective separation and quantitative determination of LCZ and its impurities. Experimental: Eight potential related impurities of LCZ were separated and identified in the bulk drug as well as oral solution dosage form. The separation was achieved on a core shell stat HPLC, Core shell, Related Substances, Levocetirizine dihydrochloride https://www.ijper.org/article/51/4s/s522-s530 2026-04-13T05:55:15.893084+00:00 Past and Future of in-vitro and in-vivo Animal Models for Diabetes: A Review 2017-12-25 10.5530/ijper.51.4s.79 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-522.pdf Diabetes mellitus is classified into two major types, Type 1 (Insulin Dependent Diabetes Mellitus) and Type 2 (Non-Insulin Dependent Diabetes Mellitus). In world about 90% of diabetes patients are of Type 2 diabetes. There are various in-vivo and in-vitro methods available for the screening of new antidiabetic drugs. In-vivo models mainly uses chemical such as streptozotocin, alloxan etc. for the induction of diabetes where as in-vitro techniques, directly show its effect on cells which are resp Diabetes, in vivo, in vitro, STZ, Alloxan https://www.ijper.org/article/51/4s/s754-s760 2026-04-13T05:55:15.893084+00:00 Development and Validation of UV-Spectrophotometric Method for Estimation of Metformin in Bulk and Tablet Dosage Form 2017-12-25 10.5530/ijper.51.4s.109 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-754.pdf Introduction: Diabetes mellitus, a metabolic disorder characterized by increased blood sugar level. Metformin hydrochloride is used to treat type I Diabetes mellitus. Metformin hydrochloride chemically 1, 1-dimethylbiguanide hydrochloride, is white crystalline powder, hygroscopic and freely soluble in water, Officially UV spectrophotometric method used for estimation of Metformin Hydrochloride from the bulk and tablets formulations. Objective: Develop and validate a simple, rapid, accurate, econ Metformin HCl, UV-Spectrophotometry, Tablet https://www.ijper.org/article/51/4s/s707-s711 2026-04-13T05:55:15.893084+00:00 Synthesis and in-vitro Antioxidant Activity of Novel Schiff Bases and Azetidines Derived from Phenyl Urea Derivatives 2017-12-25 10.5530/ijper.51.4s.102 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-707.pdf Objective: The Schiff bases and azetidines are important intermediates used in synthesis of several therapeutics and medicinally contributing molecules. This research was focused on synthesis of Schiff bases and azetidines, characterization and subsequent evaluation of their in-vitro antioxidant potentials. Methods: In this work, the Schiff bases and azetidines were derived from phenyl urea derivatives. They were tested qualitatively for melting point and characterized by TLC, FTIR, 1H-NMR, 13C- Antimicrobial, Arylamine, Chloroacetyl chloride, FTIR, GCMS, Hydrogenperoxide https://www.ijper.org/article/51/4s/s637-s644 2026-04-13T05:55:15.893084+00:00 Determining the Phytochemical Parameters of Pisum sativum (pease) and Effects on the Development of Debaryomyces hansenii 2017-12-25 10.5530/ijper.51.4s.93 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-637.pdf Objective: In this work; phytochemical parameters (fatty acid, vitamin, phytosterol, flavonoid and resveratrol contents, and antioxidant activities antimicrobial activities) of Pisum sativum (pease) extracts prepared with Debaryomyces hansenii were detected. P. sativum (pease) is known as one of the nutritional sources of prebiotics. Methods: Phytochemical contents of extracts were evaluated with device and assays like Shimadzu 17, Shimadzu brand HPLC, Spectrophotometer device and well agar meth Debaryomyces hansenii, Pisum sativum (pease), Symbiotic, Phenolic, compounds https://www.ijper.org/article/51/4s/s531-s538 2026-04-13T05:55:15.893084+00:00 Non-Animal Models for Research and Toxicity Testing of Drugs 2017-12-25 10.5530/ijper.51.4s.80 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-531.pdf All drug discovery methods, right from ‘trial-and-error’ approach to modern rational synthesis of drugs, make use of animals to check for efficacy and toxicity of compounds. This results in millions of animals being sacrificed every year. Following a global debate on “cruelty of animals”, various acts were made and enforced in order to protect animal rights. As a work, around to these animal protection acts, drug discovery scientists started finding alternative approaches to animal studies for r Refinement, Reduction, Zebra fish, Tissue culture, Caenorhabditis elegans, Saccharomyces cerevisiae, Leukotriene Inhibitory Factor https://www.ijper.org/article/51/4s/s722-s728 2026-04-20T04:59:23.951029+00:00 Comparative Study of Various Non-Nucleoside Reverse Transcriptase Inhibitors on Different Reverse Transcriptase Enzyme 2017-12-25 10.5530/ijper.51.4s.104 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-722.pdf <strong>Context:</strong> Acquired immunodeficiency Syndrome (AIDS) is caused by Human immunodeficiency virus type 1 (HIV-1). 4-Thiazolidone nulecus is the target pharmacophore which have diverse biological activities including anti HIV activity. Aim: To study binding behavior of thiazolidinone derivatives on four different crystal structures of HIV- 1RT. Material and Method: Binding pattern of some thiazolidinone derivatives was gauged by molecular docking studies on four different receptors be Molecular Docking, Thiazolidinone, HIV, NNRTI https://www.ijper.org/article/51/4s/s539-s547 2026-04-17T11:35:28.004627+00:00 Development and Evaluation of Fast Dissolving Film for Oro-Buccal Drug Delivery of Chlorpromazine 2017-12-25 10.5530/ijper.51.4s.81 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-539.pdf Objective: Objective was designed to prepare, develop and evaluate fast dissolving films (FDFs) for oro-buccal drug delivery of chlorpromazine. Background: The drug delivery through oro-buccal mucosa is very interesting one but it partially lacked oro-buccal delivery products in the market. Methods: FDFs of chlorpromazine were prepared by solvent casting method using polymers PVA, HPMCE-5, HPMCE-15 and were evaluated for film specific parameters. FDFs were also evaluated for dissolution and perc Chlorpromazine, Fast dissolving film, Oro-buccal drug delivery, in vitro, ex vivo https://www.ijper.org/article/51/4s/s700-s706 2026-04-13T05:55:15.893084+00:00 Green Expedient Synthesis of Pyrimidine Derivatives via Chalcones and Evaluation of their Anthelmintic Activity 2017-12-25 10.5530/ijper.51.4s.101 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-700.pdf Objective: In the present study, we focused on the environment-friendly processes used for the preparation of pyrimidine derivatives with pharmacological properties. In this regard, microwave heating is used as the alternative energy sources to synthesize a series of pyrimidine derivatives by the condensation of chalcones with urea under basic conditions. Chalcones were synthesized by Claisen-Schimidt condensation of acetophenone with various substituted benzaldehyde in the presence of ethanolic Anthelmintic activity, Chalcone, Claisen-schmidt reaction, Green synthesis, Pyrimidine https://www.ijper.org/article/51/4s/s691-s699 2026-04-13T05:55:15.893084+00:00 Role of Ginkgo biloba Extract, Against Isoproterenol Induced Cardiac Toxicity in Rats 2017-12-25 10.5530/ijper.51.4s.100 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-691.pdf Objective: Ginkgo biloba is a potent antioxidant dietary source for human health. Oxidative stress through generation of free radicals damages the myocardium in different experimental condition. The present research was designed to evaluate the cardio protective role of chronic oral administration of Ginkgo biloba leaf extract against Isoproterenol induced myocardial injury. Material and methods: Male Wistar albino rats were randomly divided into five groups (n = 6) and treated as per treatment Antioxidant, Cardiotoxicity, Ginkgo biloba, Isoproterenol, Wistar albino rats, α-tochopherol https://www.ijper.org/article/51/4s/s667-s674 2026-04-13T05:55:15.893084+00:00 How Human Lung Adenocarcinoma Cells React Towards Long-term Metabolic Stress; A Follow Up 2017-12-25 10.5530/ijper.51.4s.97 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-667.pdf Introduction: A key challenge in fighting against cancer is cancer recurrence and resistance. Apart from the advances in the field of cancer treatment, the outcome is not still as high as expected. This may be partly due to the poor understanding about the true biology of a tumour. Tumour is a complex tissue and cells in its central parts bear nutrition deficiency and poor angiogenesis. Objective: The main aim of this study was to investigate the effect of long-term serum starvation on an in vit Cancer, A549, Serum Starvation, Proliferation, MTT, SRB https://www.ijper.org/article/51/4s/s661-s666 2026-04-13T05:55:15.893084+00:00 Evaluation and Optimization of Effective-dose of Alloxan for Inducing Type-2 Diabetes Mellitus in Long Evans Rat 2017-12-25 10.5530/ijper.51.4s.96 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-661.pdf Background: The optimal effective and safe dose of alloxan for inducing stable diabetes in rats has been long arguable. Lower doses can result in auto-reversion from diabetogenic state to normal state. On the other hand, higher doses cause toxicity and loss of experimental animals since it completely destroys the insulin-producing pancreatic β cells. Therefore, determination of effective as well as safe dose of alloxan to induce stable diabetes in experimental Long Evan rats is crucial for inves Alloxan, Diabetes mellitus, Long Evans Rat, induced diabetes, Toxicity https://www.ijper.org/article/51/4s/s653-s660 2026-04-13T05:55:15.893084+00:00 Impact of Patient Education on Interdialytic Weight Gain and Blood Pressure in Patients Undergoing Hemodialysis 2017-12-25 10.5530/ijper.51.4s.95 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-653.pdf Objectives: To assess the impact of patient education on Interdialytic Weight Gain (IDWG) and Blood Pressure (DBP) in patients undergoing hemodialysis (HD). Materials and Methods: A Quasi experimental Pre and Post study design was conducted in an outpatient HD unit among 50 patients who were undergoing maintenance HD. The patients were educated by using validated educational material. The data on IDWG, Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) were collected at baseline, 4 Hemodialysis, Interdialytic Weight Gain, Blood Pressure, Patient Education https://www.ijper.org/article/51/4s/s712-s721 2026-04-17T11:53:37.591834+00:00 Antiobesity Potential of Fresh Cow Urine and its Distillate - A Biomedicine for Tomorrow 2017-12-25 10.5530/ijper.51.4s.103 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-712.pdf Background: The cow urine has been used traditionally for the management of many diseases and also used as bio-enhancer to improve their therapeutic effect. Objective: To prepare and evaluate the anti-obesity potential of distillate cow urine and compare with fresh cow urine against high fat diet induced obesity in Wistar rats. Materials and Methods: Qualitative analysis of fresh cow urine and its distillate was done and used for the evaluation of assessment of anti-obesity parameters like BMI, Cow urine, Distillated Cow urine, Anti-obesity, BMI, Atherogenic inde https://www.ijper.org/article/51/4s/s645-s652 2026-04-13T05:55:15.893084+00:00 Effect of Metabolic Syndrome on Depression in Mice 2017-12-25 10.5530/ijper.51.4s.94 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-645.pdf Metabolic syndrome (MetS) is associated with high blood glucose, insulin resistance, dyslipidemia, central obesity, and hypertension. There is clinical evidence of the coexistence of depression and MetS, however, pathways associating these diseases are far from clear. In the present study, we evaluate and determine the pathogenesis of depression in MetS animals. Methods: Diet induced (High-fat diet long with 20% fructose water; HFHC diet for 4 weeks) MetS was developed in swiss albino mice. Fast Depression, Dopamine, Metabolic syndrome, Norepinephrine, Obesity, Serotonin, Type 2 Diabetes https://www.ijper.org/article/51/4s/s580-s587 2026-04-13T05:55:15.893084+00:00 A Research Article on Nanogel as Topical Promising Drug Delivery for Diclofenac sodium 2017-12-25 10.5530/ijper.51.4s.86 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-580.pdf Background: Transdermal delivery of drug is promising but challenging system is available for local as well as systemic effect of drug. The prolonged residence of drug formulation in the skin is important for transdermal drug delivery. Objective: The objective of the present investigation was to develop a nanogel with reduced particle size in order to improve the bioavailability of the anti-inflammatory drug, Diclofenac sodium. Methods: The present study is to formulate nanosizes dispersion of d Diclofenac sodium, TDDS, Eudragit S-100, Glycerol, Carbopol-940, Cellophane membrane https://www.ijper.org/article/51/4s/s741-s746 2026-04-13T05:55:15.893084+00:00 Protective Effects of Biochanin A against Methotrexate-Induced Acute Liver Injury in Rats 2017-12-25 10.5530/ijper.51.4s.107 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-741.pdf Background: Methotrexate (MTX) is one of the most commonly used chemotherapeutic agents in the treatment of cancer patients, however its therapeutic use is limited due to dose dependent hepatotoxicity caused by oxidative damage. Biochanin A (BCA), a naturally occurring dietary isoflavone, has strong cytoprotective, anti-inflammatory, and antioxidant properties. Although protective actions of BCA against various chemicalinduced hepatotoxicity including that of carbon tetrachloride and arsenic, no Methotrexate, Hepatotoxicity, Biochanin A, Protective effects https://www.ijper.org/article/51/4s/s571-s579 2026-04-13T05:55:15.893084+00:00 Microemulsion Based Formulation as Drug Delivery System for Gliclazide 2017-12-25 10.5530/ijper.51.4s.85 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-571.pdf Purpose: The present study is intended to develop and evaluate oil in water (O/W) microemulsion based formulation for gliclazide as oral drug delivery system for the treatment of diabetes mellitus. Gliclazide, having sulphonyl urea moiety (Class II of BCS system) is a hydrophobic drug. Methods: Oil in water microemulsion was formulated using water titration method. Viscosity, pH, conductivity, particle size and thermodynamic stability studies were carried out for optimization followed by In vitr Microemulsion, Gliclazide, Immediate release, Pharmacokinetics, Thermodynamic stability, in vitro diffusion https://www.ijper.org/article/51/4s/s615-s622 2026-04-17T11:43:28.30958+00:00 Evaluation of Uterotonic Activity of Hydro-ethanolic Extract of Unripe Fruit of Carica papaya Linn using Wistar Albino Rats 2017-12-25 10.5530/ijper.51.4s.90 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-615.pdf Objective: This study was undertaken due to the popular belief in most of the Asian countries that the unripe fruit of Carica papaya L if eaten during early months of pregnancy can lead to miscarriage. The aim of the present study was to screen the effect of administration of hydroethanolic extract of unripe fruit of Carica papaya L (EECP). Materials and Methods: Female pregnant rats were taken and divided into various groups viz; GroupI (control); GroupII (200mg/kg p.o EECP);GroupII (400mg/kg p Carica papaya L, Antifertility, Antizygotic, Alkaloid https://www.ijper.org/article/51/4s/s735-s740 2026-04-13T05:55:15.893084+00:00 Phytochemical Screening and Evaluation of Cytotoxic Effect and Antioxidant Activity of Fractions Isolated from Stenochlaena palustri (Burm.f.) Bedd. Leaves 2017-12-25 10.5530/ijper.51.4s.106 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-735.pdf Introduction: Stenochlaena palustris (Burm.f.) Bedd. is an edible fern from Blechnaceae family, native to India through Southeast Asia to Polynesia and Australia. The study was conducted to evaluate the cytotoxic effect and antioxidant activity of fractions obtained from Stenochlaena palustris leaf extracts. Methods: Stenochlaena palustris (Burm.f.) Bedd. was tested for its antioxidant activity using DPPH assay and in vitro cytotoxic effect against HeLa cancer cell line using MTT assay. Major fr Stenochlaena palustris (Burm.f.) Bedd, Phytochemical analysis, DPPH and, MTT assays https://www.ijper.org/article/51/4s/s601-s606 2026-04-13T05:55:15.893084+00:00 Comparative in-vivo Evaluation of Anti-Cancer Drugs Loaded Nanospheres 2017-12-25 10.5530/ijper.51.4s.88 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-601.pdf Objectives: objective of present research was to formulate and evaluate nanospheres of selected anticancer drugs, viz., Capecitabine (CPN), Tamoxifen (TAM) and Doxorubicin (DXO). The adverse effects associated with anticancer drugs which include are bonemarrow depression, cardio toxicity, diarrhoea, nausea and vomiting, stomatitis and dermatitis. Materials and Methods: Drug loaded nanospheres of polycaprolactone-chitosan in various drug: polymer ratios, cross linked with Tripolyphosphate were pr Doxorubicin, Tamoxifen, Capecitabine, Nanospheres, in vivo studies https://www.ijper.org/article/51/4s/s559-s565 2026-04-17T11:36:28.052839+00:00 Nephroprotective Effect of Low Viscosity Sodium Alginate on Lead Acetate-Induced Nephrotoxicity in Rats 2017-12-25 10.5530/ijper.51.4s.83 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-559.pdf Objective: Renal failure in majority of population is considered to be idiopathic. Heavy metals like lead in drinking water are usually the hidden cause of these renal consequences. Thus, this study has been designed to investigate the effect of low viscosity sodium alginate (LvSA) in Lead-induced nephrotoxicity. Methods: Lead (0.2% lead acetate in drinking water for 5 weeks) was administered in rats to produce nephrotoxicity assessed in terms of histopathological changes, increase in serum crea Lead acetate nephrotoxicity, Glomerular blood flow, Oxidative stress, Low, viscosity sodium alginate, Proximal convoluted tubules https://www.ijper.org/article/51/4s/s623-s630 2026-04-17T11:44:18.142713+00:00 In-vitro Evaluation of Antifungal Activity of Ganoderma lucidum Against the Biofilm Producing Candida species 2017-12-25 10.5530/ijper.51.4s.91 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-623.pdf Background: Bioproducts of mushrooms Ganoderma lucidum have multi beneficial effects for human welfare. Objectives: The aim of the present study was to evaluate antifungal activity of Ganoderma lucidum against the biofilm producing fungi. In this current study it carries 100 Candida species which forms biofilms were collected from the Immunocompromised and Immuno Suppressive patients. Methods: The fruit bodies of Ganoderma lucidum were collected and done the extraction at various concentrations Ganoderma lucidum, Biofilms, Candida species, Proteinase, Phospholipase, DMSO and Methanol extracts https://www.ijper.org/article/51/4s/s588-s600 2026-04-13T05:55:15.893084+00:00 Matrix Tablet Containing Quaternary Inclusion Complex of Domperidone for Treatment of Diabetic Gastroparesis 2017-12-25 10.5530/ijper.51.4s.87 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-588.pdf Objective: The present investigation is aimed at development and optimization of a pH independent controlled release matrix tablet containing mannitol based quaternary inclusion complex (QIC) of domperidone (DOM) for the treatment of diabetic gastroparesis. Methods: The tablets were prepared by direct compression and central composite design was used to optimize the amount of sodium alginate (SA) and hydroxypropylmethylcellulose (HPMC) to obtain a final formulation with desired release character Quaternary inclusion complex, pH independent controlled release, Domperidone, Central composite design, Diabetic gastroparesis https://www.ijper.org/article/51/4s/s679-s690 2026-04-13T05:55:15.893084+00:00 Synthesis and Biological Activity of Novel 2,5-Dichloro-3-Acetylthiophene Chalcone Derivatives 2017-12-25 10.5530/ijper.51.4s.99 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4s-679.pdf Objective: A series of novel 2, 5-dichloro-3-acetylthiophene chalcone derivatives were synthesized by Claisen-Schmidt condensation and evaluated for them in vitro antifungal, antitubercular activities and cytotoxic activity against DU145 (prostate) cancer cell line. Methods: Among all series of synthesized compounds, four compounds were displayed proximity of antifungal activity (MIC ≤ 8.0 μg/mL) towards the fungus species Aspergillus niger (ATCC 6275, An) and Candida tropicalis (ATCC 1369, Ct) 2, 5-Dichloro-3-acetylthiophene chalcone derivatives, Claisen-Schmidt, condensation, Cytotoxic activity, DU145 (prostate) cancer cell line, Structure-activity, relationship, Antifungal activity, Antitubercular activity https://www.ijper.org/article/51/3s2/s398-s402 2026-04-17T10:33:27.757243+00:00 Threat Analysis and Proposed Solutions for Elekdag Wildlife Development Area 2017-09-18 10.5530/ijper.51.3s.56 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-398.pdf Natural Wildlife Development Area is a protection status declared in accordance with the Land Hunting Act No. 4915. Within this scope, there are 80 Wildlife Development Areas in our country. The aim of this study was to observe possible threats in the Elekdag wildlife development area and to suggest solutionsfor the area. Elekdag Wildlife Development Area is located in Kastamonu province within the boundaries of Tasköprü county. The administrative responsibility of Elekdag Wildlife Development A Threat Analysis, Wildlife Development Area, Wildlife, Conservation, Biodiversity, Elekdag, Kastamonu https://www.ijper.org/article/51/3s2/s518-s521 2026-04-13T05:55:18.861828+00:00 The Influence of Different Drying Methods on Essential Oil Content and Composition of Peppermint (Mentha piperita L.) in Çukurova Conditions 2017-09-18 10.5530/ijper.51.3s.78 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-518.pdf Objective: Peppermint (Mentha piperita L.) is largely cultivated and commercialized in several countries to produce peppermint oil and its medicinal compounds, cosmetic products and food purposes.1,2 In this study, the influence of different dying methods on essential oil content and composition of peppermint was determined. Material and Methods: The plants were dried separately in the sun, shadow and oven at 38oC for 48 h. The dry material was then submitted to hydro distillation in order obtai Peppermint, Drying methods, Yields, Essential oil, Menthol https://www.ijper.org/article/51/3s2/s513-s517 2026-04-17T10:49:50.400531+00:00 The Influence of Methyl Jasmonate on Growth and Caffeic Acid Derivative Contents of In vitro Shoot and Roots in Echinaceae (Echinacea Purpurea) 2017-09-18 10.5530/ijper.51.3s.77 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-513.pdf This study was carried out to determine the effects of methyl jasmonate (MeJA) applications on growth and accumulation of caffeic acid derivatives (CADs) in shoots and roots grown in vitro. For this aim, 28 days old plants obtained from seeds were cultured in ½ Murashige and Skoog media containing different concentrations of MeJA (0, 10, 50 and 100 μM) and plants were harvested in three times at 15 days intervals. After harvest, growth parameters and CADs in shoot and roots were determined, sepa Echinacea Purpurea, Methyl Jasmonate, Caffeic Acid Derives, Cichoric Acid https://www.ijper.org/article/51/3s2/s498-s503 2026-04-17T10:48:01.555996+00:00 In vitro Anticancer Activity and Antioxidant Properties of Essential Oils from Populus alba L. and Rosmarinus officinalis L. from South Eastern Anatolia of Turkey 2017-09-18 10.5530/ijper.51.3s.74 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-498.pdf Background and Purpose: In recent years, essential oils (EOs) have been reported to possess interesting anti-tumor, anti-mutagenic and anti-carcinogenic activities against various cancer cells. Therefore, we aimed to investigate potential biological activities of EOs from white poplar (Populus alba L., Salicaceae) and rosemary (Rosmarinus officinalis L., Lamiaceae). Material and Methods: EOs from P. alba L. and R. officinalis L. were extracted by hydrodistillation. MTT assay was carried out to d Cytotoxicity, Populus alba L, Rosmarinus officinalis L, DPPH, EOs, MTT, TBARS, IC50 https://www.ijper.org/article/51/3s2/s458-s462 2026-04-17T10:43:11.897636+00:00 Pharmacopoeia Analysis of Citrus aurantium L. Ssp. Amara engl. and it’s fixed oil content 2017-09-18 10.5530/ijper.51.3s.67 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-458.pdf Objective: Our aim was to take attention to Citrus aurantium L. ssp. amara Engl. (Rutaceae), which grows widely along the Mediterranean in Turkey where it has very limited medicinal usage. The bitter orange fruits/peels were analysed to find out if they are suitable to the standards in European Pharmacopoeia 7.0. The peel and fixed oil were investigated to Figure out the oil quality to apply in medicinal and cosmeceutical preparations. Material/Methods: C. aurantium were collected from different Bitter orange, Citrus Aurantium, Pharmacopoeia analysis https://www.ijper.org/article/51/3s2/s381-s384 2026-04-13T05:55:18.861828+00:00 Comparison of Antimicrobial Effects of Chemical Disinfectants with Centaury Oil 2017-09-18 10.5530/ijper.51.3s.52 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-381.pdf This study is to compare the antimicrobial activities of commercially obtained centaury oil with silver nitrate and benzalkonium chloride against the clinically important microorganisms. Six different bacteria, two yeasts, and two molds were used. The agar well diffusion method was applied to determine antimicrobial activities against used microorganisms. The antimicrobial effect of centaury oils was not confirmed but benzalkonium chloride and silver nitrate were high effects. Centaury Oils, Silver Nitrate, Benzalkonium Chloride, Antimicrobial Activity https://www.ijper.org/article/51/3s2/s385-s388 2026-04-17T10:28:51.201259+00:00 Effects of Some Plant Essential Oils against Fungi on Wheat Seeds 2017-09-18 10.5530/ijper.51.3s.53 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-385.pdf Diseases, especially caused by seed borne fungi, are among the factors decreasing yield and quality of wheat. Common bunt is also an important seed borne disease of wheat worldwide. The objective of the study is to determine the effects of clove, ginger, mint, oregano and thyme oils on the fungal load of wheat seeds. In addition, effects of the oils on the germination rates of bunt spores were investigated. Blotter method was used to determine the effects of different concentrations (0.05 – 10%) Triticum aestivum, seed-borne fungi, Tilletia spp, control, Blotter test, Germination rate https://www.ijper.org/article/51/3s2/s403-s411 2026-04-13T05:55:18.861828+00:00 Protective Effects of Bryonia multiflora Extract on Pancreatic Beta Cells, Liver and Kidney of Streptozotocin-Induced Diabetic Rats: Histopathological and Immunohistochemical Investigations 2017-09-18 10.5530/ijper.51.3s.57 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-403.pdf Objective: In this study, the ameliorative potential and antioxidant capacity of treated with different doses of Bryonia multiflora extract (BE) was investigated using histopathological and immunohistochemical changes in pancreatic beta cells, liver and kidney tissues of streptozotocin (STZ)-induced diabetic rats. Material and Methods: A total of forty-two healthy adult Wistar albino male rats were divided randomly into six groups as Control (C); Diabetes mellitus (DM); DM+Akarboz 20 mg/kg; DM+1 Diabetes mellitus Type I, Bryonia multiflora extract, Histopathology, Immunohistochemistry, Rat https://www.ijper.org/article/51/3s2/s338-s340 2026-04-17T10:23:23.205677+00:00 Berry Fruits Grown in Duzce and Its Neighborhood: Their Medical Applications 2017-09-18 10.5530/ijper.51.3s.43 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-338.pdf Berry fruits possess many positive effects on human health because of their phytochemical contents like phenolic compounds, antioxidants and anthocyanins, and they have also an important place among the functional foods. From the varieties of Isabella grape and Bursa-2 blackberry cultivated in Duzce and its neighborhood, aging-retardant cream, vinegar (cyme) which aids in the weight loss and alleviates the stomach discomfort, and grape and blackberry juice are produced. Besides, other berry frui Duzce, Berry Fruits, Bursa-2, Phenolic Compounds, Medical Usage https://www.ijper.org/article/51/3s2/s463-s469 2026-04-13T05:55:18.861828+00:00 The Essential Oil Compositions of Origanum majorana L. Cultivated in Konya and Collected from Mersin-Turkey 2017-09-18 10.5530/ijper.51.3s.68 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-463.pdf Purpose: In this study, essential oil (EO) compositions of the dried and fresh aerial parts of Origanum majorana cultivated in the research field and collected from f from Mersin was investigated. Material and Methods: EO was distilled by using Clevenger type apparatus for 3 h and the chemical compositions were detected in GC-MS. While, the oil yields of the the collected marjoram was determined to be 2,5 ml both in dried and fresh aerial parts, the yields of the cultivated plants for fresh and Oregano, Origanum majorana, Essential Oil Composition, Carvacrol, Linalool, Oil Yield https://www.ijper.org/article/51/3s2/s373-s376 2026-04-17T10:27:12.505394+00:00 Antimicrobial Activity of Echinophora tenuifolia L. and Raphanus sativus L. Extracts 2017-09-18 10.5530/ijper.51.3s.50 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-373.pdf In this study, the antimicrobial activity of Echinophora tenuifolia and Raphanus sativus extracts were tested against some pathogen microorganisms. Plant leaves were reduced to powder with liquid nitrogen. Three solvents were used for extraction. Disc diffusion method was used to test antimicrobial activity. Ten different microorganisms were used. After incubation zone diameters were measured and evaluated. Both plants extracts discovered effective against four microorganisms with similar zone d Echinophora tenuifolia, Raphanus sativus, Antimicrobial effect, Agar well, diffusion method https://www.ijper.org/article/51/3s2/s389-s392 2026-04-17T10:29:38.524561+00:00 Convective and Microwave Drying of Mushrooms (A.bisporus and P.ostreatus) 2017-09-18 10.5530/ijper.51.3s.54 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-389.pdf Dried edible mushrooms are able to be consumed in soup and sauce recipes. Utilization of A. bisporus and P. ostreatus in food formulations could bring added value to these products. In this study, A. bisporus and P. ostreatus samples were dried at 60, 70 and 80°C in conventional oven and at 180, 360 and 600 W in a microwave oven until no weight changes were observed. Among 15 thin layer drying equations, Sigmoid model gave the best results after fitting the experimental moisture ratios. The effe P. ostreatus, A. bisporus, mushroom, Drying, Mathematical modeling https://www.ijper.org/article/51/3s2/s470-s478 2026-04-13T05:55:18.861828+00:00 The Essential Oil Compositions of Rosmarinus officinalis L. Cultivated in Konya and Collected from Mersin-Turkey 2017-09-18 10.5530/ijper.51.3s.69 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-470.pdf Purpose: In this research, essential oil (EO) compositions of the dried and fresh aerial parts of Rosmarinus officinalis cultivated in the reearch field in Selcuk University Medicinal and Aromatic Plants Department Area in Konya and collected from Mersin was investigated. Material and Methods: EO was distilled by using Clevenger type apparatus for 3 h and the chemical compositions were detected in GC-MS. Results: Although, the oil yields of the collected rosemary was determined to be 0.4 ml (in Rosemary, Rosmarinus officinalis, Oil yield, Essential oil composition, Camphor https://www.ijper.org/article/51/3s2/s450-s457 2026-04-13T05:55:18.861828+00:00 Histopathological and Immunohistochemical Study of Antidiabetic Effects of Heracleum persicum Extract İn Experimentally Diabetic Rats 2017-09-18 10.5530/ijper.51.3s.66 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-450.pdf Objective: This study aims to investigate the antioxidant properties and protective effects of Heracleum persicum (HP) extract in streptozotocin (STZ)-induced diabetic rats. Material and Methods: Forty-two Wistar albino male rats were divided into six groups including Control (C); Diabetes mellitus (DM); DM+Akarboz 20 mg/kg; DM+100 mg/kg HP extract (HP1); DM+200 mg/kg HP extract (HP2) and DM+400 mg/kg HP extract (HP3). Experimental diabetes was established by a single-dose [45 mg/kg, intra-perit Heracleum persicum, Histopathology, Immunohistochemistry, Diabetes, Rat https://www.ijper.org/article/51/3s2/s445-s449 2026-04-13T05:55:18.861828+00:00 Effects of the Alternative Postharvest Treatments on ‘Hicaznar’ Pomegranate Fruit Phytochemicals, Organic Acids and Sugar Content 2017-09-18 10.5530/ijper.51.3s.65 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-445.pdf Background: There are many alternative techniques have been used for preserving fruits quality and extent shelf life by reducing metabolic activities which promote their quality changes negatively during storage to understand the metabolic process in fresh fruits. Objective: The main objective of this study was to investigate effects of postharvest treatment of gamma-aminobutyric acid (GABA) and oxalic acids (OA) on phytochemicals, organic acid and sugar content of ‘Hicaznar’ pomegranate fruit. Pomegranate Arils, Oxalic Acid, Gamma-Aminobutyric Acid, Sugar, Organic, Acid https://www.ijper.org/article/51/3s2/s349-s354 2026-04-17T10:24:42.187151+00:00 The Investigation of Phytochemical Contains, Antioxidant and Antimicrobial Activities of Malus floribunda Siebold ex Van Houtte From Eastern TURKEY 2017-09-18 10.5530/ijper.51.3s.45 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-349.pdf Objective: M. floribunda is an ornamental and landscape plant in Turkey and it’s small fruits are consumed as food. Antimicrobial, antioxidant activities and phytochemical contents of M. floribunda were investigated. Material and Method: M. floribunda was collected from different localities in the province of Elazig-Turkey. The nutritive value (flavonoid, sugar, fatty acid, vitamin, protein, element), antioxidant (lipid peroxidation, glutathione amounts and DPPH) and antimicrobial activities (on M. Floribunda, Flavonoids, Phytosterol, Apple, Antioxidant Effect, Antimicrobial Activities https://www.ijper.org/article/51/3s2/s489-s493 2026-04-17T10:46:45.413849+00:00 Total Phenolic and Flavonoid Contents, Antioxidant and Antimicrobial Activities of Traditional Unripe Grape Products 2017-09-18 10.5530/ijper.51.3s.72 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-489.pdf Unripe grape products, unripe grape juice (or koruk juice), unripe grape powder and unripe grape piece are common condiments in Kilis traditional cousin. Besides their taste roles, their probable health benefits were also studied in this work. To evaluate total phenolic and flavonoid contents, antioxidant capacity and antimicrobial activity of unripe grape samples (juice, powder and piece) extracted by various solvents. Samples were extracted separately by ethanol and distilled water (10%). Conc Phenolic, Flavonoid, Antioxidant, Antimicrobial, Unripe Grape https://www.ijper.org/article/51/3s2/s425-s428 2026-04-17T10:38:24.29088+00:00 Ornamental Asteraceae Species as New Sources of Secondary Metabolites 2017-09-18 10.5530/ijper.51.3s.61 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-425.pdf Objective: This paper presents the results regarding the morphological characters, the content in total phenols, the metabolites profile and the antioxidant activity of outdoor cultivated Rudbeckia hirta var. Goldilocks and Tagetes erecta plants. Material and Methods: The plant material was represented by flower buds and fully bloomed inflorescences taken from Rudbeckia hirta var. Goldilocks and Tagetes erecta. Morphological assessment was carried using microscopy, while chemical assessment used Rudbeckia, Tagetes, Secondary metabolites, Ornamental plants, Antioxidant, activity https://www.ijper.org/article/51/3s2/s437-s440 2026-04-17T10:40:18.205091+00:00 Essential Oil and Fatty Acid Composition and Antioxidant Capacity and Total Phenolic Content of Parsley Seeds (Petroselinum crispum) Grown in Hatay Region 2017-09-18 10.5530/ijper.51.3s.63 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-437.pdf The aim of the present study was to investigate the essential oil and fatty acid compositions and antioxidant capacity and total phenolic content of parsley seeds grown in Arsuz/ hatay region. Parsley seeds had a moisture content of 12,6 wt.% and ash content of 6,86 wt.% while the essential oil content of 2,52 wt.% and total lipid content of 8,85 wt.%. The essential oil was analyzed by gas chromatography and thirty two volatile compounds were determined. The composition of fatty acids were also Parsley seed, Essential oil, Fatty acid, Antioxidant activity, Phenolic content https://www.ijper.org/article/51/3s2/s494-s497 2026-04-13T05:55:18.861828+00:00 Potential of Alternanthera philoxeroides on Improvement of Anxiety-Like Behavior Induced By Ovariectomized Mice Model 2017-09-18 10.5530/ijper.51.3s.73 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-494.pdf Background: Ovariectomy (OVX) causes estrogen deprivation and oxidative stress leads to the hippocampus cell death and affected on mood disorders such as anxiety. Alternanthera philoxeroides was folk used for blood tonic and neuroprotective. Objectives: The action of A. philoxeroides extract (AP) on anti-anxiety in OVX mice model was evaluated and chromatographic fingerprint of AP was analyzed. Methods: Mice were ovariectomized to induce estrogen deprivation which involved anxiety. AP (250 and 5 Alternanthera philoxeroides, Ovariectomy, Anxiety, Neuroprotective, Behavior, Flavonoids https://www.ijper.org/article/51/3s2/s417-s420 2026-04-17T10:36:32.110612+00:00 Angiotensin-Converting Enzyme (ACE) Inhibitory Effects of Hazelnut Protein Hydrolysate Prepared Using Pepsin 2017-09-18 10.5530/ijper.51.3s.59 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-417.pdf Objective / Purpose: The aim of this study is to find out the effect of protein isolate and pepsin hydrolysates of hazelnut protein on Angiotensin-Converting Enzyme (ACE) inhibition. Material and Methods: Unshelled hazelnuts (Corylus avellana L.) was firstly grinded and defatted by petroleum ether. Alkaline extraction and isoelectric precipitation method was used in order to obtain protein isolate. Neutralized protein suspension was freeze dried before analysis and stored at -18ºC. Pepsin hydrol Hazelnut, Pepsin Hydrolysis, ACE Inhibition, Anti-Hypertensive https://www.ijper.org/article/51/3s2/s421-s424 2026-04-17T10:37:34.254777+00:00 Dried Extracts and Essential Oils of Some Pelargonium Species: Chemical and Biological Assessment 2017-09-18 10.5530/ijper.51.3s.60 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-421.pdf Our aim was to evaluate the beneficial properties of the most important groups of compounds present in the leaves of Pelargonium hispidum, P grandiflorum and P. radens. Given the studied species have a high content of polyphenols, the biologic activity was assessed by determination of free radical scavenging capacity against DPPH, and the investigation of superoxide anion radical scavenging capacity. The volatile fractions from the Pelargonium samples were separated by distillation with water va Pelargonium, Essential Oils, Gas-Chromatography, Antioxidant Activity, polyphenols https://www.ijper.org/article/51/3s2/s330-s332 2026-04-17T10:21:38.397919+00:00 Indian Spices and their Medicinal Value 2017-09-18 10.5530/ijper.51.3s.41 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-330.pdf The history of spices is the history of humankind itself, with empires rising and falling based on the trade of exotic spices from distant lands, their intoxicating allure changing and shaping the very foundations of our society. Christopher Columbus set sail for the Indies (following the unorthodox notion of getting there faster by heading in exactly the wrong direction), he was searching for pepper. Not gold or jewels, but pepper and other spices. He never found the passage to the Indies he wa Humankind, 2000 BCE, Old French https://www.ijper.org/article/51/3s2/s333-s337 2026-04-17T10:22:49.176942+00:00 Investigation of Some Chemical Characteristics of Wild Edible Cephalaria schrader ex Roemer & schultes G.C. Setosa Boiss & Hohen grooving in East Anatolia 2017-09-18 10.5530/ijper.51.3s.42 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-333.pdf Nutritional value and mineral compositions of wild edible plants have been investigated for food security and human health. It is though that wild edible plants gathered from nature are cheaper food and important for human health. They are also special ingredients for distinguished taste and aroma of traditional cousins. Thus, in the present study the nutritional value and mineral composition of used parts of Cephalaria schrader was investigated. In laboratory analysis, dry matter, total ash, % Nutrient content, Wild plant, Cepheleria, East Anatolia, Nutrient content, wild plant, Cepheleria https://www.ijper.org/article/51/3s2/s341-s348 2026-04-17T10:24:10.670158+00:00 The Effect of Fertilization and Mycorrhiza Inoculation on Yield Variables and Essential Oil Characteristics of Salvia officinalis L. Growing in the Greenhouse and at the Field 2017-09-18 10.5530/ijper.51.3s.44 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-341.pdf Common sage (Salvia officinalis L.) is one of the most valuable commercial medicinal and aromatic plants (MAP). It has served different treatments historically in folk medicine and has always been popular to use. This research was conducted to observe the effect of mycorrhiza infection and fertilization to the biomass and quality characteristics on common sage. The optimum N, P, K dosses and their combinations (NP, NK, PK, NPK) were applied to both +M (mycorrhiza infected) and –M (non mycorrhiza Common Sage (salvia officinalis L.), Fertilization, Mycorrhiza Spp. Biomass, Essential Oil Yield, Camphor, Α-Thujone https://www.ijper.org/article/51/3s2/s393-s397 2026-04-17T10:33:01.593591+00:00 Extraction of Phenolic Compounds from Oven and Microwave Dried Mushrooms (Agaricus bisporus and Pleurotus ostreatus) by Using Methanol, Ethanol and Aceton as Solvents 2017-09-18 10.5530/ijper.51.3s.55 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-393.pdf Mushrooms can be native, less handled and readily present source of natural antioxidants. In this study, dried Agaricus bisporus and Pleurotus ostreatus were extracted with 80 % methanol, ethanol and acetone seperately. Total phenolics and antioxidant acitivities of extracts were determined by Folin-Ciocalteu method and DPPH and FRAP methods, respectively.The highest total phenolic contents were 31727 mg GAE (on d.b.), 33201 mg GAE (on d.b.) in methanolic extract of non-dried A. bisphorus and P. P. ostreatus, A. bisporus, Phenolic, Extraction, Drying https://www.ijper.org/article/51/3s2/s412-s416 2026-04-17T10:35:54.862318+00:00 Effect of Thermal Treatment on Synephrine, Ascorbic Acid and Sugar Content of Citrus aurantium (Bitter Orange) Juice 2017-09-18 10.5530/ijper.51.3s.58 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-412.pdf Objective / Purpose: The aim of this study was to understand the change of synephrine, ascorbic acid and sugar contents after thermal treatment of peeled and grated Citrus aurantium (Bitter Orange) Juice. Material and Methods: Citrus aurantium was extracted either by peeling or grating methods. Clarification of juice was achieved by a pectic enzyme. After filtration, juices were thermally treated using rotary evaporator until 67ºBrix. Synephrine, sugar and ascorbic acid analysis were performed w Bitter (Sour) Orange, Citrus aurantium, Ascorbic Acid, Synephrine, Thermal, Treatment https://www.ijper.org/article/51/3s2/s429-s436 2026-04-17T10:39:23.919432+00:00 Chemical Composition, Antimicrobial and Antioxidant Activities of the Essential Oil of Bursera graveolens (Burseraceae) From Perú. 2017-09-18 10.5530/ijper.51.3s.62 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-429.pdf Palo santo oil is an important component of the traditional Peruvian medicine and is known to have antibacterial properties. This essential oil is extracted from fallen branches of the tree B. graveolens. To validate some of its properties, the antimicrobial and antioxidant activities of palo santo oil obtained from northern Peru were first examined. Based on the measurements of the diameter of growth inhibition (Agar Disc Diffusion method), antimicrobial activities ranging from moderate to high Bursera graveolens, Antimicrobial Activity, Antioxidant Activity, Total, Phenolic, Terpinene https://www.ijper.org/article/51/3s2/s479-s482 2026-04-17T10:44:48.267395+00:00 Quality of Juniper Essential Oil (Oleum Juniperi) in the South Slovakia and it’s Curative and Industrial Utilization 2017-09-18 10.5530/ijper.51.3s.70 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-479.pdf Common juniper, Juniperus communis L., is a shrub or tree species belonging to the Cypress family (Cupressaceae). It has wide ecological amplitude and the aromatic plants occur abundantly in dry sunny hillsides, as well as the subalpine level. The essential oil is distilled from the fresh and dry black, ripe berries. Juniper essential oil (Oleum juniper) is transparent, fluid and colourless, sometimes with a tinge of greenishyellow. The principal essential oil constituent is pinene, which has tw Berries, Cancer, Curative Effects, Juniper, Pinene, Spirits https://www.ijper.org/article/51/3s2/s483-s488 2026-04-17T10:45:56.368322+00:00 Regulation of MicroRNAs by Natural Products and Bioactive Compounds Obtained From Common Medicinal Plants: Novel Strategy in Cancer Therapy 2017-09-18 10.5530/ijper.51.3s.71 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-483.pdf MicroRNAs (miRNAs) are highly conserved non-protein coding small RNAs, known to contribute to the epigenetic regulation process in various cancer cells, including the regulation of progression, proliferation and metastasis of cancer cells, differentiation of the cells and process of apoptosis. In addition to, they are crucial for the regulation of cancer stem cells, and management the process of epithelial to mesenchymal transition of cancer cells, implicating in the cancer cells. Further to thi MicroRNAs, Cancer Therapy, Natural Products, Bioactive Molecules, Medicinal Plants, Nutri-Epigenetics https://www.ijper.org/article/51/3s2/s363-s367 2026-04-13T05:55:18.861828+00:00 Investigation of Some Antibacterial and Antioxidant Properties of Wild Cirsium vulgare from Turkey 2017-09-18 10.5530/ijper.51.3s.48 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-363.pdf Background: Cirsium vulgare (Savi) Ten; belongs the Asteraceae family and has common uses in some countries folk medicine. Objective: In this study, the determination of some antioxidant and antimicrobial properties of C. vulgare which is wild-grown from Turkey is aimed. Methods: Crude extracts of plants were obtained by using n-hexane, diethyl ether, ethyl acetate and methanol as solvent. Total phenolic content (TPC) and DPPH (2,2-diphenyl 2,2-diphenyl-1 picrylhydrazyl picrylhydrazyl) scavengin Cirsium vulgare, Phenolic content, DPPH activity, Antibacterial activity, P, aeruginosa https://www.ijper.org/article/51/3s2/s355-s358 2026-04-17T10:25:18.780811+00:00 The Involvement of NO–cGMP–ATP Sensitive K+ Channels Pathway in Protocatechuic Acid Peripheral Analgesia 2017-09-18 10.5530/ijper.51.3s.46 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-355.pdf Protocatechuic acid (PCA) is a widely distributed natural bioactive phenolic acid. The various pharmacological activities such as antioxidant, antidiabetic and anti-inflammatory activities have been identified. However, the studies focused on the analgesic effect of protocatechuic acid are limited and the action mechanisms of PCA still remain unclear. The NO-cGMP-ATP-sensitive K+ channels pathway is one of the mechanism of action for various analgesic drugs. The present study was conducted to in Protocatechuic Acid, Pain, No–Cgmp–Atp Sensitive K+ Channels, Writhing, Test https://www.ijper.org/article/51/3s2/s368-s372 2026-04-17T10:26:44.153006+00:00 Biodiversity of Gavurdag Wildlife Development Area 2017-09-18 10.5530/ijper.51.3s.49 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-368.pdf Natural resources are depleting due to detrimental effects of human interventations. The preservation and rehablitation of these areas are critical. It is very important to identify existing floristic and faunistic elements of these sites for management and future studies. The main purpose of these strategies is to protect and develop the target species and other resource values of the protected area. Besides this, it is also aimed to protect the floristic and faunistic value of the conservation Biodiversity, Flora, Fauna, Wildlife, Gavurdag https://www.ijper.org/article/51/3s2/s359-s362 2026-04-13T05:55:18.861828+00:00 Free Radical Scavenging Capacity and Antibacterial Activity of Wild Cirsium creticum from Turkey 2017-09-18 10.5530/ijper.51.3s.47 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-359.pdf Background: In recent years, there is increasing interest the using of herbal extracts derived from plants in medicine and as a dietary supplements. Objective: We aimed the determination of the antioxidant and antibacterial activity of Cirsium creticum (Lam) d’Urv. subsp. creticum included Asteraceae family which is wild plant species in Trakya region. Methods: Crude n-hexane, diethyl ether, ethylacetate and methanol extracts from whole plants was used the determination of antiradical and antiba Cirsium creticum, Antiradical activity, Antimicrobial activity, E. coli, S, aureus https://www.ijper.org/article/51/3s2/s377-s380 2026-04-13T05:55:18.861828+00:00 Evaluation the Antimicrobial Effects of Pistacia terebinthus L. and Papaver rhoeas l. Extracts Against Some Pathogen Microorganisms 2017-09-18 10.5530/ijper.51.3s.51 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-377.pdf In this study, the antimicrobial activity of Pistacia terebinthus L. and Papaver rhoeas L. extracts were tested against some pathogen microorganisms. Leaves of the plant samples were freeze-dried and powdered. Three solvents were used for extraction. The agar well diffusion method is used for the antimicrobial activities of extracts. Six different bacteria, two yeasts, and two molds were used. The extracts of P. terebinthus L. was found more effect than P. rhoeas L. extracts against tested bacte Pistacia terebinthus L, Papaver rhoeas L, Folkloric Medicine, Antimicrobial, Effect, Agar well diffusion method https://www.ijper.org/article/51/3s2/s508-s512 2026-04-17T10:49:20.71997+00:00 Effects of Methyl Jasmonate and Caffeic Acid Applications on Secondary Metabolite Production in Madder (Rubia tinctorum) Root Cultures 2017-09-18 10.5530/ijper.51.3s.76 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-508.pdf This study was carried out to determine the effects of methyl jasmonate (MeJA) and caffeic acid (CA) applications on the root growth index and contents of total anthraquinones (AQs), alizarin, purpurin, total phenolic (TP) and individual phenolic compounds in madder (Rubia tinctorum) roots grown in vitro conditions. For this aim, in vitro adventitious roots derived from internode parts were cultured in Murashige and Skoog media containing two different concentrations of MeJA (10 and 100 μM) and Rubia Tinctorum, Root Culture, Caffeic Acid, Methyl Jasmonate, secondary, metabolite, madder https://www.ijper.org/article/51/3s2/s504-s507 2026-04-17T10:48:40.746899+00:00 Mineral Composition of Acorn Coffees 2017-09-18 10.5530/ijper.51.3s.75 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-504.pdf Background and Purpose: Wild plant nuts have been important food resources, mainly staple substitute in food crisis periods, during the human history. Acorns which are fruits of Quercus trees growing in Mediterranean climate are also important wild food and feed source with high nutritive value. Besides its folkloric food uses for human diets and important feed source especially in poultry, processed acorns have been used as herbal coffee in some regions. Nutritional values and mineral compositi Acorn Coffee, Functional Food, Herbal Coffee, Minerals, Quercus Coccifera L https://www.ijper.org/article/51/3s2/s441-s444 2026-04-13T05:55:18.861828+00:00 Home Garden Herbs and Medicinal Plants of Lefke, Cyprus 2017-09-18 10.5530/ijper.51.3s.64 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s2-441.pdf The objective of this study was to record edible herbs and fruits derived from home gardens in Lefke, Cyprus and in addition to determine the local residents’ knowledge of medicinal uses of home growing plants within their home gardens. This study was performed in old Turkish Cypriot town Lefke, Cyprus. During the surveys between November 2016 and February 2017 the fruit and edible herb production was documented and standard interviews were performed with garden owners. A total number of nine he Herbs, Medicinal, Traditional, Home Gardens, Rural, Cyprus https://www.ijper.org/article/51/4/502-509 2026-04-17T10:53:17.931124+00:00 Designing of Curriculum Aspects of Pharmacy Undergraduate Course in Respect of Graduate Employability 2017-07-22 10.5530/ijper.51.4.78 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-502.pdf Objectives: Objective of the present research work was to enhance graduate employability based on the needs of pharmaceutical industries, to evaluate present undergraduate curriculum and to redefine it by conducting survey of industrial, academic professionals other than pharmacy and clinical professionals. Materials and Methods: Questionnaire survey design of 15 multiple choice questions, was prepared to generate opinions of four types of professionals, industrial, academic, clinical and profes Graduate employability, Questionnaire survey design, Samples from human, subjects, F-statistics https://www.ijper.org/article/51/4/748-757 2026-04-17T11:25:02.950336+00:00 Synthesis, Characterization, Antimicrobial, DNA cleavage, and Cytotoxicity Studies of Some Metal (II) Complexes of Tridentate Schiff Base Ligand: 2-hydroxy-3-((4-(4-phenylthiazol-2-yl) semicarbazide) methyl) Benzoic Acid 2017-07-22 10.5530/ijper.51.4.109 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-748.pdf Objective: The main aim of the present work was to synthesize a novel Schiff base ligand 2-hydroxy-3-((4-(4-phenylthiazol-2-yl) semicarbazide) methyl) benzoic acid is obtained by the condensation of N-(4-phenylthiazole-2-yl) hydrazine carboxamide with 3-Aldehydosalicylic acid and its Cu(II), Co(II), Ni(II), and Zn(II) complexes and study of their biological activity. Methods: The compounds are characterized by elemental analysis and various physicochemical techniques like IR, 1 H NMR, ESI-mass, Transition metal complexes, Thaizole, Schiff base, Antimicrobial, DNA, cleavage https://www.ijper.org/article/51/4/684-691 2026-04-13T05:55:16.592425+00:00 Response Surface Methodology Optimization of Thebaine Biotransformation into Codeine and Morphine Using Bacillus sp. FAR 2017-07-22 10.5530/ijper.51.4.101 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-684.pdf Background: Codeine and morphine are important pharmaceuticals having analgesic characteristics. Aim: The current study used response surface methodology to optimize the biotransformation of thebaine into codeine and morphine using Bacillus sp. FAR. Methods: A central composite design was used to determine the optimal concentrations of buffer and thebaine, pH, time, temperature, and biomass. Improvement in transformation was monitored using HPLC-DAD. Results: The optimized conditions employed we Biotransformation, CCD, Codeine, Morphine, Thebaine, Bacillus https://www.ijper.org/article/51/4/525-534 2026-04-13T05:55:16.592425+00:00 Formulation and Characterization of Tapentadol Loaded Emulgel for Topical Application 2017-07-22 10.5530/ijper.51.4.81 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-525.pdf Background: Tapentadol is a centrally acting analgesic drug which falls under class III drug as per biopharmaceutical classification systems having poor bioavailability. Aim: Therefore, present study was aimed at solubility and permeability enhancement of Tapentadol using emulsomes loaded emulgel drug delivery system. Methods: Emulgel was prepared using data light liquid paraffin, Tween 20 and PEG 400 as Surfactant and Co-surfactant respectively. For preparation of stable Emulgel, micro emulsion Tapentadol, Microemulsion, Emulgel, Skin Permeation, Optimization, Topical, Delivery https://www.ijper.org/article/51/4/597-602 2026-04-13T05:55:16.592425+00:00 Silibinin: An Inhibitor of Mir-181a Gene Expression in Sk-Br-3 Breast Cancer Cell Line 2017-07-22 10.5530/ijper.51.4.89 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-597.pdf Background: Mir-181a has been considered as an attractive molecular target for breast cancer therapy. The main objective of this work is to assess the inhibitory effects of silibinin, a herbal substance, on proliferation, apoptosis and Mir-181a gene expression in human breast cancer cell line SK-BR-3. Materials and Methods: Human breast cancer cell line SK-BR-3 was treated with various concentration of silibinin. Cell viability was assessed by MTT assay and apoptosis by flow cytometry. Expressio Silibinin, Cell Viability, Apoptosis, Sk-Br-3 Cell Line, Mir-181a https://www.ijper.org/article/51/4/613-619 2026-04-13T05:55:16.592425+00:00 Simultaneous Determination of Linezolid and Levamisole Hydrochloride in a Fixed Dose Combination 2017-07-22 10.5530/ijper.51.4.91 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-613.pdf Background: The combination of antibiotics with an immune-stimulant can be used for the prevention of antimicrobial resistance. Multilayer tablets of linezolid and levamisole hydrochloride can be a solution of this problem. Objective: Aim of the present study was to High Performance Liquid Chromatography method development and validation as per the International Council for Harmonisation guidelines for analysis of both the drugs simultaneously in a single unit dosage form. Methods: Ammonium acet HPLC, Levamisole hydrochloride, Linezolid, Antibacterial resistance, Antimicrobial resistance https://www.ijper.org/article/51/4/758-764 2026-04-13T05:55:16.592425+00:00 Development of Proniosomal Gel: in-vitro, ex-vivo and in-vivo Characterization 2017-07-22 10.5530/ijper.51.4.110 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-758.pdf The aim of the present research work was to characterize the ex-vivo, in-vitro and in-vivo studies of proniosomal (PN) gel of ketorolac tromethamine (KT). Experimental work: Proniosomal suspension was prepared by rotatory flask evaporator with addition of nonionic surfactant (Sodium Cholate) at concentration ranges (3%, 2% and 1%). Co-solvent like isopropanol, butanol and ethanol as well as dimethyl sulphoxide (DMSO), was later added which act as permeability enhancers in gel formulations. Carbo Ketorolac Tromethamine, Carbopol 940, Proniosomal Gel, Permeability, inflammation https://www.ijper.org/article/51/4/706-712 2026-04-17T11:16:42.714881+00:00 Identification of Bioactive Compounds and Possible Mechanism of Hepatoprotective Activity of Ficus microcarpa l. Fil. Bark Extracts in Ethanol-Induced Chronic Hepatic Injury in Rats 2017-07-22 10.5530/ijper.51.4.104 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-706.pdf Objective: To evaluate the effect of the successive extracts of the FMB on ethanol induced chronic hepatotoxicity. Furthermore, to understand the mechanisms of its pharmacological actions, the in vivo antioxidant activity and major phytoconstituents of FMB were investigated. Methodology: Ficus microcarpa L. fil., (FM) is commonly known as ‘Indian Laurel’, is used for liver complaints in Indian traditional practice. The hepatoprotective effect of four successive extracts (petroleum ether 60-80o, Hepatoprotective, Ficus microcarpa, Ethanol, Antioxidant, Catechin, Oleanolic, acid, Betulinic acid https://www.ijper.org/article/51/4/580-587 2026-04-13T05:55:16.592425+00:00 Micellar Properties and Antimicrobial Activityof a Mixed Surfactant System Constituted by Sodium Dodecyl Sulfate and Cetylpyridinium Chloride 2017-07-22 10.5530/ijper.51.4.87 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-580.pdf Objective: Micellar properties of sodium dodecyl sulfate (NaDS) was examined in the presence of cetylpyridinium chloride (CPC) by means of surface tension, viscosity, dye solubilization, cloud point (CP) measurements.Antimicrobial activities of single and binary systems were also investigated. Results: A decrease in critical micelle concentration (CMC) and increase in solubilizing power for NaDS was observed with increasing CPC concentration. At the highest CPC concentration studied (0.1 M), the Mixed Micellization, NADS, CPC, Antimicrobial Activity https://www.ijper.org/article/51/4/510-516 2026-04-17T10:54:54.153679+00:00 Experience of Introduction of the Online Course in Biology for Pharmacy Students in Ukraine 2017-07-22 10.5530/ijper.51.4.79 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-510.pdf Introduction: Distance learning is getting more and more popular all over the world and more recently it expanded into Ukraine. The objective of work was to clarify the experience of development and principles of the on-line course “Biology and Genetics Principles” for pharmacy students in one of the oldest universities of Ukraine – National University of Pharmacy. Methods: The study was conducted using the method of observation and analysis using modern IT technologies. Analysis was conducted b Distance Learning, Ukraine, Pharmacy Students, Biology, Course Structure/, Assessments https://www.ijper.org/article/51/4/626-635 2026-04-17T11:08:30.046729+00:00 Development and Validation of an Analytical Method for Related Substances in N-acetyl–L-cysteine Effervescent Tablets by RP-HPLC 2017-07-22 10.5530/ijper.51.4.93 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-626.pdf Background: The reported chromatographic methods for N-acetyl cysteine [NAC] are reverse phase HPLC and ion pair chromatography [IPC] for related substances test in bulk and in formulations. No reported stability indicating methods for the estimation of related substances in NAC effervescent formulation was found in literature. Objective: The present work was aimed at developing a selective, sensitive and reproducible stability indicating high-performance liquid chromatographic method for the qu N-acetyl cysteine, Reverse phase HPLC, Effervescent formulation, Ion pair, chromatography, Related substances, Validation https://www.ijper.org/article/51/4/729-739 2026-04-13T05:55:16.592425+00:00 Attenuation of Oxidative Stress and Hepatotoxicity Induced By D–Galactosamine by a Polyherbal Formulation Ambrex–in vivo and in vitro Studies 2017-07-22 10.5530/ijper.51.4.107 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-729.pdf Objective: To evaluate the hepatoprotective effect of Ambrex, a polyherbal formulation against D–galactosamine (D-GLN) induced hepatotoxicity in Swiss albino mice as well as in Chang liver cell lines. Materials and Methods: Ambrex was orally administered for a period of 7 days at dose levels of 250 and 500 mg/kg b.wt. D-GLN (250 mg/kg b.wt, i.p) was administered 24h prior to sacrifice the animals. The protective effect of Ambrex was evaluated by measuring plasma levels of aspartate transaminase Ambrex, D- Galactosamine, Hepatotoxicity, Chang Cells, Antioxidants https://www.ijper.org/article/51/4/650-655 2026-04-13T05:55:16.592425+00:00 Synthesis, Characterization and Antibacterial Evaluation of Some Azole Derivatives 2017-07-22 10.5530/ijper.51.4.96 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-650.pdf Purpose: Tremendous rise in development of resistance to the antimicrobials has created alarming situation for researchers and clinicians. Method: In this regard, an attempt has been made to develop a series of azole derivatives using Claisen-Schmidt condensation and Micheal addition. All the newly synthesized compounds were authenticated by IR, 1H NMR, 13C NMR and MS spectral analysis. Synthesized compounds 5 (a-e) and 6 (a-e) were screened for their antibacterial activity against three Gram po Pyrazole, Synthesis, Claisen-Schmidt condensation, Micheal addition, Antibacterial https://www.ijper.org/article/51/4/700-705 2026-04-17T11:15:44.847305+00:00 The Total Phenolic Contents and Antioxidant Activities of Endemic Species Ajuga postii Briq. and Ajuga relicta P.H.Davis (Lamiaceae) from Turkey 2017-07-22 10.5530/ijper.51.4.103 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-700.pdf Background: Ajuga species are anthelmintic, diuretic, antifungal, and antimycobacterial agents.Lamiaceae members Ajuga postii Briq. and Ajuga relicta P.H.Davis are local endemic species of Turkey. Aim: To give information about the total phenolic contents and antioxidant activities of the species. Methods: The total phenolic contents of the extracts have been quantified with Folin Ciocalteu colorimetric method, and the antioxidant activities of the extracts have been tested with DPPH, ABTS, and ABTS, Ajuga, β-Carotene / Linoleic Acid Assay, DPPH, Total Phenolic Content https://www.ijper.org/article/51/4/692-699 2026-04-13T05:55:16.592425+00:00 Evaluation of Unsaponified Petroleum Ether Extract of Lantana camara L. leaves for Antioxidant Activity and Oxidative Stability 2017-07-22 10.5530/ijper.51.4.102 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-692.pdf Background: Lantana camara L. leaves have been traditionally claimed to be used in treatment of different illnesses. Leaves are rich in lower terpenes in the form of essential oil, however they also contain lipids like waxes. Both classes, lipids and terpenes are soluble in petroleum ether, but only lipids can be saponified, not terpenes. Aim: The present study was aimed towards preparation of unsaponified terpene-rich extract of L. camara L. leaves; its assessment for anti-oxidant activity and Lantana camara L, Terpenes and Tepenoids, DPPH Radical Scavenging, Activity, Rancimat Test, Unsaponified petroleum ether extract https://www.ijper.org/article/51/4/636-643 2026-04-13T05:55:16.592425+00:00 Determination on Vildagliptin in Rat Plasma by Capillary Electrophoresis Tandem Mass Spectrometry: It’s Application to Pharmacokinetic Study 2017-07-22 10.5530/ijper.51.4.94 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-636.pdf Background: Vildagliptin, a dipeptidyl peptidase-4 inhibitor, is one of the potent oral antidiabetic agent. Objective: The objective of the present work was to establish a rapid, sensitive and validated capillary electrophoresis Quadrupole Time-of-flight Mass Spectrometry method from rat plasma. Methodology: Vildagliptin was estimated in rat plasma after precipitation of plasma proteins by acetonitrile, using sitagliptin as internal standard. For separation of vildagliptin from plasma components Vildagliptin, CE, Mass Spectrometry, Validation, Plasma, Pharmacokinetics https://www.ijper.org/article/51/4/664-671 2026-04-17T11:11:20.760057+00:00 Ligand Based in-silico Study on Pyridopyrimidinedione Derivatives as Dipeptidyl Peptidase-IV Inhibitors 2017-07-22 10.5530/ijper.51.4.98 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-664.pdf Background: Type-2 diabetes mellitus can be effectively treated with dipeptidyl peptidase- IV inhibitors. Diverse classes of molecules have exhibited promising DPP-IV inhibition. Objective: In this perspective, 3D-QSAR and pharmacophore studies on a series of substituted pyridopyrimidinedione derivatives were performed to explore the structural requirements for effective DPP-IV inhibitory activity. Methods: 3D-QSAR was performed on 3D-QSAR module of Vlife molecular design suite (MDS) while two s DPP-IV, 3D-QSAR, kNN, Pharmacophore, Pharmagist https://www.ijper.org/article/51/4/536-542 2026-04-17T10:58:44.75527+00:00 Development and Characterization of Fast Dissolving Oral Films of Orciprenaline Sulphate 2017-07-22 10.5530/ijper.51.4.82 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-536.pdf Introduction: From past few decades there has been a massive change in designing various drug delivery systems to achieve rapid onset of action to treat sudden surprising disorders like hypertensive reactions. Fast dissolving oral films enhance the efficacy of APIs by dissolving within a minute in oral cavity after the contact with less saliva without chewing and need of water for administration. Orciprenaline Sulfate belongs to the category of bronchodilators, beta-adrenergic agonist. It is ver Orciprenaline sulphate, HPMC E15, HPMC E50, Fast-dissolving oral films, drug permeated https://www.ijper.org/article/51/4/722-728 2026-04-17T11:22:50.048172+00:00 Comparative Evaluation of in vitro Cellular Uptake and Antiproliferative Potential of Different Extracts of Orthosiphon pallidus Royle 2017-07-22 10.5530/ijper.51.4.106 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-722.pdf Objective: Evaluation of the cytotoxic effect of different extracts of Orthosiphon pallidus Royle on MCF-7 cell lines, comparatively. Materials and Methods: The breast cell line MCF-7 was cultured in DMEM medium containing fetal bovine serum & antibiotics. The cells were exposed to different doses of all the ethanolic, aqueous and hydroalcoholic extracts and incubated for 24, 48 and 72 hrs respectively and further studied for MTT colorimetric test, SRB test, glutathione assay and cellular uptake Breast Cancer, Cytotoxic Effect, MCF-7 Cell Line, Fetal Bovine Serum, Glutathione’s https://www.ijper.org/article/51/4/571-579 2026-04-13T05:55:16.592425+00:00 Poly(lactic acid-co-glycolic acid) Nanospheres Improved the Oral Delivery of Candesartan Cilexetil 2017-07-22 10.5530/ijper.51.4.86 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-571.pdf Purpose: Certain physicochemical characteristics of Candesartan Cilexetil (CC) lead to incomplete oral absorption and poor clinical efficacy. This study assessed the prospect of the use of drug-embedded nanospheres to augment the oral bioavailability of CC. Methods: Baseline studies were conducted to measure the solubility of CC in the polymer. Drug encapsulated poly(lactic acid-co-glycolic acid) nanospheres were prepared by emulsion solvent evaporation method. Five different formulations (C1-C5 Nanospheres, Release, Polymer, Evaluation, in vivo, Bioavailability https://www.ijper.org/article/51/4/543-550 2026-04-13T05:55:16.592425+00:00 β-Cyclodextrin-g-Poly (2-(dimethylamino) ethyl methacrylate) as the Stabilizer and Reductant to Prepare Colloid Silver Nanoparticles in situ 2017-07-22 10.5530/ijper.51.4.83 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-543.pdf Background: The preparation of silver nanoparticles often involves some tedious steps and extra reducing agents. PDMAEMA and β-CD can act as the reducing and stabilizing agents for the preparation of silver nanoparticles without any external reducing agent. Methods: β-Cyclodextrin-g-Poly (2-(dimethylamino) ethylmethacrylate) as the stabilizer and reductant to prepare colloid silver nanoparticles in situ. Such an approach greatly simplified the preparation and purification of silver nanoparticles Silver Nanoparticles, Poly(2-(Dimethyl amino) Ethyl Methacrylate), β-Cyclodextrin, in situ Method https://www.ijper.org/article/51/4/740-747 2026-04-13T05:55:16.592425+00:00 A Study on Antimicrobial Evaluation of Newly Synthesized Antipyrin Analogues 2017-07-22 10.5530/ijper.51.4.108 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-740.pdf The antipyrinyl derived molecules are a versatile building blocker organic compounds and used in medicinal drug research. A versatile range of hybrid molecules have been synthesized by diazotization of 4-aminoantipyrin and further substituted with six different coupling components. The structures of the synthesized compounds have been confirmed by different spectral techniques. The antimicrobial activity of the synthesized molecules is investigated by agar well diffusion method against a wide ra Diazotization, Antimicrobial, Acute Toxicity, Solvatochromic https://www.ijper.org/article/51/4/679-683 2026-04-13T05:55:16.592425+00:00 Formulation of an Emulgel Containing Strawberry Fruit Extract and in-vivo Evaluation for Different Skin Parameter 2017-07-22 10.5530/ijper.51.4.100 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-679.pdf Introduction: It has been indicated from previous research that strawberry consumption may be beneficial to improve skin appearance and its extract has antioxidant and antiinflammatory effects. Objective: The aim of present study was to fabricate an emulgel containing extract of strawberry (4%) and in-vivo evaluation on different skin parameters versus its base taken as control. Methods: Strawberry fruit extract, which was obtained by concentrating methanolic extract of strawberry fruit, was ent Strawberry, Emulgel, Stability, Melanin, Sebum, Erythema https://www.ijper.org/article/51/4/588-596 2026-04-17T11:04:22.550213+00:00 Gamma Amino Butyric Acid Ameliorates Jejunal Oxidative Damage in Diabetic Rats 2017-07-22 10.5530/ijper.51.4.88 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-588.pdf Introduction: The small intestine exhibits morphological and functional changes in streptozotocin (STZ)-induced diabetes. This study was carried out to clarify the role of gamma-aminobutyric acid (GABA) in ameliorating the histopathological changes and the oxidative stress in small intestine of the diabetic rats. Material and Methods: For this purpose, 40 adult male Swiss albino rats (Sprague dawley strain) were divided into 4 groups (10 animals in each group); the control group, GABA treated gr Diabetes, Jejunum, Morphometry, Paneth Cells, Gamma-Aminobutyric Acid. https://www.ijper.org/article/51/4/672-678 2026-04-13T05:55:16.592425+00:00 Biological Activities of Black Garlic Fermented with Lactobacillus plantarum PN05 and Some Kinds of Black Garlic Presenting Inside Vietnam 2017-07-22 10.5530/ijper.51.4.99 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-672.pdf Background: Black garlic has become more popular in Vietnam due to its interesting biological activities. Purpose: The quality of different black garlic preparations should be checked. Methods: 1010 colony forming units (CFUs) of Lactobacillus plantarum PN05 were mixed with 1 kg fresh garlic and then let turn into black garlic. The aqueous extract of this preparation and other black garlic products marketed in Vietnam were evaluated on antimicrobial, anticancer cell line activities and toxicity Black Garlic, Lactobacillus plantarum Pn05, Antimicrobial Activity, Anticancer, Activity, Spleen Toxicity https://www.ijper.org/article/51/4/656-663 2026-04-13T05:55:16.592425+00:00 Calprotectin Complex Interactions with Phytoquinolines and New Target Binding Alternates Calprotectin complex and Phytoquinolines 2017-07-22 10.5530/ijper.51.4.97 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-656.pdf Objective: S100 proteins, the low molecular weight calcium binding proteins, have ‘EF hand’ type conformation. They are identified as markers for various diseases. A member of S100 protein family, S100A9 is involved, in performing important biological functions, by coordinating with S100A8. S100A9 targeted interactions of quinoline-3- carboxamides, differentiates quinoline derivative interaction among varying single point substituents. Inhibition of protein interaction with many important biolog Quinoline, Calprotectin, Molecular Interaction, Ligand, ADMET https://www.ijper.org/article/51/4/620-625 2026-04-17T11:07:28.090919+00:00 Determination of Tl(I) Ions in Homeopathic Drugs by Differential Pulse Anodic Stripping Voltammetry 2017-07-22 10.5530/ijper.51.4.92 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-620.pdf Objectives: The present study is focused on the determination of thallium (I) ions in homeopathic drugs. Methods: The determination was carried out using the Differential Pulse Anodic Stripping Voltammetry (DPASV) technique coupled with the flow-injection measuring system (FIA-DPASV). Results: The thallium content was analyzed in two commercial homeopathic preparations (Thallium aceticum 5CH and 9CH), which include two different concentrations of thallium. It was established, that the mean conce Flow-Injection Differential-Pulse Anodic Stripping Voltammetry, Heavy Metal, Ions, Homeopathic Drugs, Thallium, Trace Analysis https://www.ijper.org/article/51/4/644-649 2026-04-13T05:55:16.592425+00:00 Novel RP-HPLC Method Development and Validation of Meloxicam Suppository 2017-07-22 10.5530/ijper.51.4.95 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-644.pdf Objective: A simple reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed and validated for simultaneous determination of Meloxicam drug (MLX) in pharmaceutical mixture. Methods: Effective chromatographic separation achieved using a phenomenex luna C18 (4.6 mm, 250 mm, 5 μm) column with isocratic elution by the mobile phase composed of 0.02 M Potassium dihydrogen orthophosphate, pH adjusted to 4 with orthophosphoric acid (filtered): acetonitrile (50:50) respe Meloxicam, RP HPLC, Method Development, Validation, Suppository, Novel https://www.ijper.org/article/51/4/551-561 2026-04-13T05:55:16.592425+00:00 Development and Evaluation of a System for Colonic Delivery of Budesonide 2017-07-22 10.5530/ijper.51.4.84 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-551.pdf In the present study an attempt has been made to address low solubility issue and colonic delivery of Budesonide by developing enteric coated capsule containing Budesonide in a nano emulsifying drug delivery system. Herein, the formulated liquid SNEDDS was transformed to a solid form by spray draying method. Subsequently, it was filled into capsules coated with pH sensitive polymer, Eudragit S- 100 along with band sealing. However, the drug solubility is an important parameter which was determin SNEDDS, Colonic Release, Budesonide, Solubility, In vitro, In-vivo, Ulcerative, Colitis https://www.ijper.org/article/51/4/517-524 2026-04-17T10:55:52.911896+00:00 Preparation and Evaluation of Matrix Type Transdermal Patches of Domperidone Maleate: in vitro and ex vivo Characterization 2017-07-22 10.5530/ijper.51.4.80 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-517.pdf Objective: Domperidone Maleate is a dopamine - receptor (D2) antagonist, widely used in the treatment of motion sickness and used as an antiemetic. The bioavailability of domperidone maleate when administered orally is low due to the first pass metabolism in liver, drug delivery through transdermal drug delivery has the ability to deliver the drug directly to systemic circulation by passing the liver and hence increase in bioavailability of the drug. The main aim of this investigation is to deve Domperidone Maleate, Matrix type transdermal patches, Permeation, enhancer, in vitro release, ex vivo permeation, Flux https://www.ijper.org/article/51/4/603-612 2026-04-13T05:55:16.592425+00:00 An Evaluation of Antioxidant Potential of Flavonoid Eriodictyol in Isoproterenol-Induced Myocardial Infarction in Rats 2017-07-22 10.5530/ijper.51.4.90 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-603.pdf Aim: The study was designed to evaluate the antioxidant potential of eriodictyol on lipid peroxidation caused due to isoproterenol induced myocardial infarction in albino male wistar rats. Methods: Myocardial Infarction was induced by subcutaneous injection of isoproterenol, 85 mg/Kg body weight after a pretreatment period of 45 days with eriodictyol in various doses 50 mg, 100 mg and 200 mg per Kg body weight through intragastric intubation. The standard drug metoprolol succinate was administer Myocardial infarction (MI), Isoproterenol (ISO), Eriodictyol (E), Lipid, peroxidation, Antioxidants, Acute Myocardial Infarction (AMI) https://www.ijper.org/article/51/4/562-570 2026-04-17T11:01:56.033102+00:00 Solid Dispersion of Nateglinide in Polyoxy Ethylene-Polyoxy Propylene Block Copolymer: in vitro and in vivo Evaluation 2017-07-22 10.5530/ijper.51.4.85 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-562.pdf Objective: The study was aimed to improve solubility and bioavailability of nateglinide preparing stable solid dispersions with polyoxy ethylene-polyoxy propylene block copolymer (poloxamer 188). Methods: The solid dispersions were prepared by the melting and solvent technique at 1:1, 1:2, 1:3 (w/w) of drug to carrier ratios. The formulations were characterized by fourier transform infrared spectroscopy, diffrential scanning calorimetry, X-ray diffraction, scanning electron microscopy, dissoluti Nateglinide, Poloxamer 188, Bioavailability, Crystallinity, Solid dispersion https://www.ijper.org/article/51/4/713-721 2026-04-13T05:55:16.592425+00:00 Quality Standardization and Nephroprotective Effect of Garcinia pedunculata Roxb. Fruit rind 2017-07-22 10.5530/ijper.51.4.105 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-4-713.pdf Fruit rind of Garcinia pedunculata is one of the important medicinal plant and a condiment used in Indian kitchen. In spite of many medicinal properties ascribed to this species, less of pharmacological studies are carried out on this species. The objective of present study was to determine the quality standards of the fruit rind followed by evaluation of nephroprotective activity of aqueous extract in cisplatin induced nephrotoxicity. Macromicroscopic, physico-chemical, preliminary phytochemica Antioxidant, Cisplatin, Nephroprotective, Serum Creatinine, Quality Standards https://www.ijper.org/article/51/3s1/s190-s194 2026-04-17T09:49:16.631513+00:00 Morphogenetic, Ontogenetic and Diurnal Variability in Antimicrobial Activity of Bitter Fennel (Foeniculum vulgare Miller var. vulgare) Essential Oil 2017-07-14 10.5530/ijper.51.3s.10 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-190.pdf Background: There has been considerable interest in antimicrobial activity of plant essential oils in recent years. Objectives: This research was carried out to determine morphogenetic, ontogenetic and diurnal variability in antimicrobial activity of bitter fennel essential oil. Methods: To specify morphogenetic variability, leaf and root-bulb-stalk samples taken at pre-, full and post-flowering, flower samples picked at full flowering and seed samples gathered at two seed growth stages were use Antibacterial, Antifungal, Growth inhibition, Minimal inhibition concentration, Volatile oil https://www.ijper.org/article/51/3s1/s304-s308 2026-04-17T10:08:27.357185+00:00 A Survey on the Aromatic Plants of Libya 2017-07-14 10.5530/ijper.51.3s.35 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-304.pdf Objectives: The aim of this study is to investigate on some aromatic plants growing in Libya, their major volatile oils contents and traditional uses, indicating dangerous hazards facing plant biodiversity especially medicinal plants and measures taken to protect them. Methods: The study is mainly based on electronic database survey using Scopus, PubMed, and Science Direct, etc. and communication with Libyan local inhabitants of some areas. Gathered information has been evaluated and summarized Aromatic Plants, Volatile Oils, Traditional Uses, Endemic Species, IUCN, Missions https://www.ijper.org/article/51/3s1/s213-s216 2026-04-13T05:55:19.84398+00:00 Antioxidant, Antimicrobial Activities and Phenolic and Chemical Contents of Physalis peruviana L. from Trabzon, Turkey 2017-07-14 10.5530/ijper.51.3s.15 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-213.pdf Background: Goldenberry (Physalis peruviana L.) is one of the most promising exotic fruits in terms of its biological capacity. Objective: In this work, ethanol extracts of the different parts (fruit, seed, root, body and leaf) of the P. peruviana were investigated in terms of their antioxidant and antimicrobial activity. Furthermore total phenolic and flavonoid contents, phenolic analysis and volatile compound analysis were exhibited. Method: Total phenolic and flavonoid contents were calculted Antioxidant, Antimicrobial, Physalis peruviana L, DPPH, HPLC, GC-MS https://www.ijper.org/article/51/3s1/s249-s253 2026-04-13T05:55:19.84398+00:00 Medicinal Plants Used in Meriç Town from Turkey 2017-07-14 10.5530/ijper.51.3s.23 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-249.pdf Background: There are a few studies on medical plants used in the Trakya region of Turkey (Havsa, Lalapasa, Uzunköprü, Ipsala, Enez, Kirklareli). However, there has been no research study performed investigating the preparation and medicinal uses of wild plants in Meriç town. Aim: The aim of this study is to determine the parts of locally growing medicinal plants used by local people in Meriç town and the purpose of their use. Methods: In this study, 16 villages in Meriç town (Edirne province, T Edirne, Ethnobotany, Medicinal plants, Meriç town, Turkey https://www.ijper.org/article/51/3s1/s217-s220 2026-04-17T09:53:24.722027+00:00 Heavy Metal Contents of Melissa Which is Sold in Herbalists 2017-07-14 10.5530/ijper.51.3s.16 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-217.pdf The purpose of this study is to determine the heavy metal content that is important in human health and the plants sold as Melissa L. in herbalists. Plant samples were purchased from 14 different herbalist and specimens were identified by Flora of Turkey. Heavy metal contents (Fe, Co, Mn, Zn, Al, Cd) and some nutrients (Na, K, Ca, Mg) were identified by the ICP-OES method. As a result of the diagnoses, 4 of 14 samples were Melissa officinalis L. and others were identified as Lippia citriodora. A Melissa, ICP, Heavy Metal, Herbalists, Turkey https://www.ijper.org/article/51/3s1/s254-s257 2026-04-17T09:57:57.463548+00:00 Effects of Different Basil Hydrosol Doses on the Germination and Shoot and Root Lenghts of Basil (Ocimum basilicum) and Quinoa (Chenopodium quinoa) Seeds 2017-07-14 10.5530/ijper.51.3s.24 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-254.pdf Objective: Medicinal and aromatic plants (MAPs) have allelopathic effects on seed germination, root and shoot length due to the chemicals included in their extracts or essential oils. In this study, the changes in the germination rate, and shoot and root length of basil (Ocimum basilicum) and quinoa (Chenopodium quinoa) seeds exposed to different concentrations of basil hydrosol have been investigated. Material and Methods: The treatments included distilled water (control), tap water and differe Hydrosol, Essential Oil, Quinoa, Basil, Germination, Shoot and Root Lengths https://www.ijper.org/article/51/3s1/s180-s184 2026-04-17T09:48:01.025847+00:00 Anti-Inflammatory Effects of Essential Oils from Rosmarinus officinalis and Populus alba on Experimental Models of Acute and Chronic Inflammation in Rats 2017-07-14 10.5530ijper.51.3s.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-180.pdf Objective / Purpose: Essential oils (EOs) distelled form aromatic plants have a wide range of uses because of their rich pharmacological activities including, antiinflammatory, antitumor, antimicrobial, antioxidant, antidiabetic and hepatoprotective. The present research aimed to investigate in-vivo anti-inflammatory effects of EOs from Rosmarinus officinalis and Populus alba as biomarker levels in well-defined acute and chronic inflammation models. Material and Methods: The anti-inflammatory ac Anti-inflammatory, Essential oils, Experimental model, Rosmarinus officinalis, Populus alba https://www.ijper.org/article/51/3s1/s176-s179 2026-04-17T09:47:14.094381+00:00 Application of Bioapigyn® Herbal Ointment for the Treatment of Lower Genital Tract Infections 2017-07-14 10.5530/ijper.51.3s.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-176.pdf Objective: The purpose of this work was development and testing of new herbal ointment for the treatment of lower genital tract infections in females. Material and Methods: 80 female patients with positive swabs to at least one microorganism (U. urealyticum, M. hominis, E. coli and Candida sp.) were randomly divided into three treatment groups. First group was treated 12 days (twice a day) with doxycycline antibiotic and 2 g of Bioapigyn vaginal ointment (once a day), second group with 2 g of o Bioapigyn Vaginal ointment, Essential oils, Medicinal plants, Honey, Genital, infections https://www.ijper.org/article/51/3s1/s318-s322 2026-04-13T05:55:19.84398+00:00 Differential Influence of Seabuckthorn on the In vivo and In vitro Cell-Mediated Immune Responses in Chickens with Gumboro Disease 2017-07-14 10.5530/ijper.51.3s.38 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-318.pdf Objective/Purpose: The study intended to clarify the restoring effects of an alcoholic seabuckthorn extract on the cell-mediated immunity in chickens with Gumboro disease. Material and Methods: Graft rejection was performed in vivo on healthy, Gumboro virus infected and convalescent chickens, by injecting 0.1 ml of a sheep lymphocyte suspension (5x106 cells/ml) mixed 1:1 with either saline or an alcoholic seabuckthorn extract. Wattle thickness was measured before and 24, 48 and 72 hours post inj Chicken, Gumboro Disease, Immunity, Hippophae https://www.ijper.org/article/51/3s1/s290-s294 2026-04-17T10:04:57.673663+00:00 Influence of Chicken Manure Applications on the Yield and the Essential Oil content of Origanum onites L. 2017-07-14 10.5530/ijper.51.3s.32 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-290.pdf Background: Origanum onites L. is one of the most important export plant collected from natural flora and cultuvated in Turkey. Methods: This study was conducted to determine the effects of different doses of chicken manure on yield characteristics of O. onites, in Odemis, Izmir ecological conditions during 2014 and 2015 vegetation periods. The experiment was established as randomized blocks design with three replications and five chicken manure (0, 10, 20, 30, 40 ton ha-1) were applied. Results Oregano, Fertilization, Fresh herb yield, Dry herb yield, Dry leaf yield, Essential oil https://www.ijper.org/article/51/3s1/s276-s280 2026-04-17T10:02:00.88287+00:00 Harvest Number and Growing Season Effects on Quality and Health Related Compounds in Parsley 2017-07-14 10.5530/ijper.51.3s.29 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-276.pdf Background and Purpose: Parsley is mostly grown outdoors and harvested seasonally. Farmers in many parsley producing countries, especially in the temperate region such as Turkey usually prefer spring sowings (summer growing season-SGS) and fall sowings (winter growing season-WGS) for open field production. Parsley can be usually harvested 4-8 times in temperate climates, if some special precautions are taken it may be 10- 15 times. In arid, hot and cold climate regions, 2-4 harvests can be obtai Petroselinum, crispum L, Dry Matter Content, Chlorophylls, Antioxidant, Activity, Total Phenol https://www.ijper.org/article/51/3s1/s299-s303 2026-04-17T10:07:28.106419+00:00 Separarion and Identification the Speciation of the Phenolic Compounds in Fruits and Leaves of Some Medicinal Plants (Juniperus phoenicea and Quercus coccifera) Growing at Al –Gabal Al –Akhder Region (LIBYA). 2017-07-14 10.5530/ijper.51.3s.34 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-299.pdf The contents of the phenolic compounds can be summarizing as following :Juniperus phoenicea leaves :4,5-Dicaffeoly guinic acid (0.003047 mg/g), Cinnamic acid (0.00000696 mg/g), Galic acid (0.0161mg/g) Geraniol (0.000644 mg/g), Phloridzin (0.00000297 mg/g), Quercetin (0.02033 mg/g) and Catecin (0.0424 mg/g). On the other side in Juniperus phoenicea fruits: 3,4-Dicaffeoly guinic acid (0.00115 mg/g), Galic acid (0.0000975 mg/g and Catecin (0.0424 mg/g). While in Quercus coccifera plan : The concent Medicine plants, Phenolic compounds, Libya https://www.ijper.org/article/51/3s1/s281-s285 2026-04-17T10:02:31.243094+00:00 Comparison of Volatile Compounds Profile and Antioxydant Activity of Allium sativum Essential Oils Extracted using Hydrodistillation, Ultrasound- Assisted and Sono-Hydrodistillation Processes 2017-07-14 10.5530/ijper.51.3s.30 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-281.pdf Objective: This work aims to evaluate the impact of the use of ultrasound during essential oils extraction from garlic bulbs. Material and methods: The essential oils were extracted by Conventional Hydrodistillation method (HD), Ultrasound-Assisted hydro-distillation (US-HD) and Sono-hydrodistillation (SHD) and compared using yield profile, chemical composition and antioxidant activity. Results: Higher performances were obtained when the direct application of ultrasound were used. Indeed, SHD al Garlic essential oil, GC-MS, Antioxidant activity, Hydrodistillation, Ultrasound https://www.ijper.org/article/51/3s1/s327-s329 2026-04-17T10:11:34.690375+00:00 Development of a Novel Biotechnological Fragrant Product, Eremothecium Oil 2017-07-14 10.5530/ijper.51.3s.40 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-327.pdf The assessment of Eremothecium oil biological activity via kinetics modelling revealed valid positive correlations between level of bacterial multiplication and lag-phase prolongation under different concentrations (from 0.49 to 7.81 μL/mL). Toxicity intensity correlated with phenyl ethanol (R = –0.9; strong negative association), geraniol (R = 0.6; moderate positive association), nerol (R = –0.55; moderate negative association), linalool (R = –0.74; strong negative association), and total monot Biotechnology, Essential Oil, Microbial Synthesis, Eremothecium, Toxicity, Fragrant Compounds https://www.ijper.org/article/51/3s1/s258-s261 2026-04-17T09:58:51.627858+00:00 Antioxidant Activities of Satureja hortensis L. Essential Oil during the Flowering Period 2017-07-14 10.5530/ijper.51.3s.25 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-258.pdf Objective: This study was conducted to investigate the changes of total phenolic concentration and antioxidant activity of Satureja hortensis L. during the flowering stage cultivated under the ecological conditions of Rize, Turkey. Material and Methods: The plantation was established with natural cuttings of Satureja hortensis L. Cuttings were obtained at three stages (pre-flowering, full flowering, and post-flowering) and dried in an oven at 35°C. The analysis of essential oil in the leaves and Satureja hortensis L, antioxidant activity, essential oil, polyphenol content, harvest times https://www.ijper.org/article/51/3s1/s200-s204 2026-04-17T09:51:03.714216+00:00 Chemical Composition and Antimicrobial Activity in Cold Press Oil of Fennel, Anise, White and Black Mustard Seeds 2017-07-14 10.5530/ijper.51.3s.12 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-200.pdf In this study, the cold press oil components and antimicrobial activities of fennel (Foeniculum vulgare) and anise (Pimpinella anisum) and white mustard (Sinapis alba) and black mustard (Brassica nigra) species seeds, which are widely used by the people for alternative medicine, were determined. F. vulgare, P. anisum, S. alba and B. nigra species seeds were obtained from cultivated areas in central Anatolia in Turkey. The oil was extracted by using a screw press (MP-001 Cold Press, Turkey), and Cold Press Oils, Gs-Mc, Antioxidant Activity and Antimicrobial Activities https://www.ijper.org/article/51/3s1/s313-s317 2026-04-13T05:55:19.84398+00:00 The Potential Role of Antigen Priming In Increasing the Overall Antimicrobial Resistance in Captive Silver Foxes 2017-07-14 10.5530/ijper.51.3s.37 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-313.pdf Objective: We hypothesized antigenic priming should stimulate the humoral and cellmediated adaptive immunity, further improved by vegetal extracts, alleviating the immune suppression induced by captivity stress in silver foxes. Material and Methods: One of two groups of adult silver foxes was sc primed and boosted 7 days later with a 5% SRBC suspension. Serum antibody titers (hemagglutination test) and circulating immune complexes levels (4.2% PEG precipitation) were quantified and ln of the ant Silver Foxes, Antigenic Stimulation, Adaptive Immunity, Vegetal Extracts https://www.ijper.org/article/51/3s1/s295-s298 2026-04-13T05:55:19.84398+00:00 Effect of Sumac (Rhus Coriaria L.) Fruit Powder as an Antibiotic Growth Promoter Substitution on Growth Performance, Immune Responses and Serum Lipid Profile of Broiler Chicks 2017-07-14 10.5530/ijper.51.3s.33 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-295.pdf Objective: The experiment was conducted to evaluate effect of different levels of sumac (Rhus coriaria L.) fruit powder as an antibiotic growth promoter (AGP) substitution on performance, immune responses and serum lipid profile of broiler chicks. Materials and Methods: A totally of 260 one-day-old broiler chicks (Ross 308) were used in a completely randomized design with four treatments. The treatments consisted of basal diet (control) and basal diet with AGP (flavophospholipol), 3 or 7 g/kg su Broiler chick, Sumac, Performance, Immunity, Serum lipid https://www.ijper.org/article/51/3s1/s309-s312 2026-04-13T05:55:19.84398+00:00 Contribution to a Study of the Effect of the Essential Oil of Henna (Lawsonia inermis L), on the Biological Aspect of White Scale (Parlatoria blanchardi targ) of Date Palm 2017-07-14 10.5530/ijper.51.3s.36 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-309.pdf The study was carried to evaluate the effect of the essential oil of henna’s leaves on the biological aspects (egg, larvae and adults stages) of Parlatoria blanchardi. The insect is one of the serious pest infected the date palm cultivated in Algeria. The sample of leaves of date palm infested by the insect putted in Petri dishes were treated under the laboratory conditions with 05 treatments (C0, C1, C2, C+, C-); two were obtained by the dilution of the essential oil (the concentration of 5 % a Bioinsecticide, Essential oil, White scale, Serious pest, Laboratory conditions, High mortality https://www.ijper.org/article/51/3s1/s170-s175 2026-04-13T05:55:19.84398+00:00 The Antibacterial Activities of Piper nigrum L. Against Mastitis Pathogens and its Antioxidant Activities 2017-07-14 10.5530/ijper.51.3s.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-170.pdf Objective / Purpose: Bacteria causes one of the most common types of chronic mastitis. The most common causative organisms of mastitis include: Staphylococci, Streptococci and coliforms. The scope of this work was to research the antibacterial effects of Piper nigrum extracts against mastitis pathogens, and its antioxidant capacity. Materials and Methods: In our study, 2 Staphylococcus aureus and 5 Coagulase Negative Staphylococcus were used for experiments. Additionally, Piper nigrum were colle Piper, Mastitis, Staphylococcus, Antibacterial Activity, Antioxidant Activity https://www.ijper.org/article/51/3s1/s286-s289 2026-04-13T05:55:19.84398+00:00 An optimization of the extraction and the physicochemical proprieties of the essential oil of Lawsonia inermis L. cultivated in Biskra (Department of Algeria) 2017-07-14 10.5530/ijper.51.3s.31 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-286.pdf Introduction: The henna plant Lawsonia inermis L.,is one of the oldest cosmetic, medicinal and aromatic plants, well known in the worldwide. Objective: This study is the optimization of the extraction of the essential oil from the aerial part of Lawsonia inermis L plant. Two methods of extraction were compared; the hydrodistillation and the microwaves extraction, from the leaves, the flowers and the seeds of henna plant. The obtained essential oil was analyzed in laboratory to determine its orga Henna, essential oil extraction, hydrodistillation, microwaves, AFNOR norms https://www.ijper.org/article/51/3s1/s147-s147 2026-04-13T05:55:19.84398+00:00 EDITORIAL 2017-07-14 10.5530/ijper.51.3s.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-147.pdf Having respected scientific board and organizing committee members from all over the world, MESMAP Symposium series started in 2013. The first Mediterranean Symposium on Medicinal and Aromatic Plants (MESMAP-2013) was held on April 17-20, 2013 in Gazimagosa (Famagusta), Turkish Republic of Northern Cyprus (TRNC), which was organized by Faculty of Pharmacy, Eastern Mediterranean University (EMU) joint with AMAPMED (Association of Medicinal and Aromatic Plants of the Mediterranean). https://www.ijper.org/article/51/3s1/s185-s189 2026-04-13T05:55:19.84398+00:00 Compositions of the essential oils of Ballota nigra subsp. uncinata and subsp. anatolica from Turkey 2017-07-14 10.5530ijper.51.3s.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-185.pdf Background: Ballota nigra L. is a member of Lamiaceae family and is represented in the Flora of Turkey by five subspecies. Subsp. uncinata is a mediterranean element while subsp. anatolica is a Irano-Turanian phytogeographic region. Material and Methods: The essential oils from aerial parts of subsp. uncinata and subsp. anatolica were isolated by hydrodistillation. The analysis was performed by using a gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) systems, simultaneous Ballota nigra, Essential oil, subsp. uncinata, subsp. anatolica, Turkey https://www.ijper.org/article/51/3s1/s205-s208 2026-04-13T05:55:19.84398+00:00 Essential Oil of Oregano and Savory; Chemical Composition and Antimicrobial Activity 2017-07-14 10.5530/ijper.51.3s.13 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-205.pdf The essential oils of oregano (Origanum vulgare ssp. hirtum) and savory (Satureja thymbra) plants were obtained through steam distillation method. The chemical compositions of their essential oils were analyzed via GC-MS technique. Furthermore, their antimicrobial activities were studied by using minimum inhibitory concentration (MIC) method. Their chemical composition was found as carvacrol (63.97%), p-cymene (12.63%) and linalool (3.67%) in oregano essential oil as major compounds and also, as Oregano, Savory, Essential Oil, GC-MS, Antimicrobial Activity https://www.ijper.org/article/51/3s1/s244-s248 2026-04-13T05:55:19.84398+00:00 Antimicrobial Activity and Chemical Composition Screening of Anacyclus pyrethrum Root 2017-07-14 10.5530/ijper.51.3s.22 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-244.pdf Medical herbs have many bioactive component and they are used in microbial treatment since ancient times. The resistance of pathogens to antibiotics became a critical problem, so researches for novel antimicrobial agents are required. Anacyclus pyrethrum (pellitory, Spanish chamomile or Mount Atlas daisy) is commonly used as a traditional medicine, therefore the antimicrobial activity of the root of this medicinal plant was investigated against 17 bacteria and 1 fungi by using disk diffusion met Anacyclus pyrethrum, Medicinal Plant, Antimicrobial Activity, Chemical, Composition, Disk Diffusion Method, Gc-Ms https://www.ijper.org/article/51/3s1/s230-s233 2026-04-13T05:55:19.84398+00:00 Determination of Antimicrobial Activity and Chemical Composition of Pimento & Ginger Essential Oil 2017-07-14 10.5530/ijper.51.3s.19 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-230.pdf The essential oil was obtained from pimento (Pimenta racemosa Mill.) and ginger (Zingiber officinale Rosc.) through hydrodistillation method. The chemical composition of pimento and ginger essential oils were analyzed by GC-MS. It was found that the most abundant components were methyleugenol (52.33%) and zingiberene (16.32%) in essential oils of pimento and ginger, respectively. The antimicrobial activities of essential oils were investigated against 18 microorganisms with minimum inhibitory co Pimento, Ginger, Essential oil, Antimicrobial Activity, Hydrodistillation, method, Chemical composition https://www.ijper.org/article/51/3s1/s209-s212 2026-04-13T05:55:19.84398+00:00 Profile of Heavy Metal and Nutrient Elements in Some Sideritis Species 2017-07-14 10.5530/ijper.51.3s.14 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-209.pdf Background: Medicinal plants are the basic raw material of various herbal formulations in folk medicine in all over the world. In recent years, regarding quality and safety of plant materials collected from different ecological conditions, there has been a growing worldwide interest in monitoring heavy metal contamination and its effect on plant growth and nutrient uptake in medicinal and aromatic plants. Objectives: In this study, profile of heavy metal and selected nutrient elements (Al, Cd, C Herbal tea, Heavy metal, Folk medicine, Medicinal plants, Trace elements https://www.ijper.org/article/51/3s1/s271-s275 2026-04-17T10:01:03.454699+00:00 Food Plants Used in Meriç Town from Turkey 2017-07-14 10.5530ijper.51.3s.28 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-271.pdf Background: Local people are using the plants those are growing naturally in proximity for many purposes, for example pharmaceutical, food, decoration, and ornamental. In recent years, the number of scientists who are interested in ethnobotany has increased. Aim: The aim of this study was to determine the plants used for food by the local people in the province of Meriç and its villages. Methods: 16 villages were visited and interviews were performed with elderly people of the villages, 38 perso Edirne, Food plants, Meriç, Turkey https://www.ijper.org/article/51/3s1/s239-s243 2026-04-13T05:55:19.84398+00:00 Antimicrobial Activity and Chemical Composition Screening of Epilobium montanum Root 2017-07-14 10.5530/ijper.51.3s.21 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-239.pdf Medical herbs have many bioactive component and they are used in microbial treatment since ancient time. The resistance of pathogen to antibiotic is became a critical problem, so novel antimicrobial agent related research is required. Epilobium montanum related antimicrobial research doesn't exist, therefore root of this medicinal plant investigation was applied against 17 bacteria and 1 fungi by using disk diffusion method. These microbial species include Bacillus, Enterobacter, Enterococcus, E Epilobium montanum, Medicinal Plant, Antimicrobial Activity, Chemical, Composition, Disk Diffusion Method, GC-MS https://www.ijper.org/article/51/3s1/s268-s270 2026-04-13T05:55:19.84398+00:00 Effect of Edible Mushroom Powder on Antioxidant Activity of Tarhana 2017-07-14 10.5530/ijper.51.3s.27 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-268.pdf Background: In this study, two edible mushroom (Morchella conica and Ramaria flava) were used to raise the biological value of tarhana. Objective: Tarhana was supplemented with two edible mushroom species to improve its nutritional value and functional properties. Method: Antioxidant activities of tarhana were analysed by using different assays. Total phenolic (TPC) and flavonoid contents (TFC) were also determined. Results: Tarhana with mushroom had high total phenolic, flavonoid contents as we Tarhana, Fermented Product, Antioxidant Activity, Phenolic, Flavonoid, Frap https://www.ijper.org/article/51/3s1/s323-s326 2026-04-13T05:55:19.84398+00:00 Correlation of Predictor Variables to Squalene Content in Olive Fruits Using Multivariate Statistical Analysis 2017-07-14 10.5530/ijper.51.3s.39 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-323.pdf The present study was designed to examine the correlation of some predictor variables including pH, organic matter (OM), lime (L), phosphorus (P), potassium (K) and total salt (TS) content of soils of olive orchards to squalene content of olive fruits. Multiple linear regression analysis was used to model the relationship between explanatory variables (pH, OM, L, P, K and TS) and responses variable (squalene content) by fitting a linear equation to observed data. The olive fruits (Kilis Yaglik c Squalene, Olive oil, Soil characteristics, Kilis Yaglik cv, Multivariate statistical, analysis https://www.ijper.org/article/51/3s1/s152-s158 2026-04-17T09:44:26.640187+00:00 Herbal Cosmetics and Novel Drug Delivery Systems 2017-07-14 10.5530/ijper.51.3s.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-152.pdf Herbal cosmetics are defined as the products which prepared by or included plants and/or herbal components which are combination of many natural molecules or compounds. In this context, critical parameters that affect the final quality and stability of herbal cosmetics are the specifications of herbal inputs, structure of formulation and manufacturing process. In addition to produce according to the good manufacturing practices of cosmetics (ISO 22716) in case of being natural or organic cosmeti Herbal cosmetics, Naturel sources, Novel delivery systems, Standards, Stability https://www.ijper.org/article/51/3s1/s225-s229 2026-04-13T05:55:19.84398+00:00 Determination of Some Flavonoids and Antimicrobial Behaviour of Some Plants' Extracts 2017-07-14 10.5530ijper.51.3s.18 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-225.pdf C. sativa, C. intybus, L. stoechas, V. officinalis and G. glabra plants were extracted by using 65% ethanol to isolate their active constituents. The antimicrobial activities of extracts were investigated against 15 microorganisms by using the disk diffusion method, MIC (Minimum Inhibitory Concentration), MBC (Minimum Bactericidal Concentration) and MFC (Minimal Fungicidal Concentration) tests. Furthermore, the presence of eight flavonoids were analysed by using HPLC. It was found that C. sativa Soxhelet Extraction, Antimicrobial Activity, Flavonoid, MIC, Disc Diffusion https://www.ijper.org/article/51/3s1/s234-s238 2026-04-13T05:55:19.84398+00:00 Antimicrobial Activities and Some Flavonoids in Extracts of Some Medicinal Plants 2017-07-14 10.5530/ijper.51.3s.20 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-234.pdf Origanum majorana, Melissa officinalis, Anthemis cotula and Avena sativa were extracted by using 65% ethanol to isolate their active constituents. The antimicrobial activities of extracts were investigated against 15 microorganisms by using the disk diffusion method, MIC (Minimum Inhibitory Concentration), MBC (Minimum Bactericidal Concentration) and MFC (Minimal Fungicidal Concentration) tests. Furthermore, the presence of some flavonoids were analyzed by using HPLC. It was determined flavonoid Origanum majorana, Melissa officinalis, Anthemis cotula, Avena sativa, Antimicrobial activity, Flavonoid https://www.ijper.org/article/51/3s1/s163-s169 2026-04-13T05:55:19.84398+00:00 Antibacterial Activities of Mentha piperita L. Extracts Against Bacteria Isolated from Soccer Player’s Shoes and its Antioxidant Activities 2017-07-14 10.5530/ijper.51.3s.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-163.pdf Objective: Microorganisms have an easier entry into the sportsman’s epidermis, and these make diseases on athletes. The main scope of the study is to search the lack of information about the biological activities of Mentha piperita extracts against bacteria isolated from soccer player’s shoes. Materials and Methods: The bacteria were isolated from soccer player’s shoes from Balikesir Spor soccer team after the competition. The plant extracts were tested by disc diffusion assay for antibacterial Soccer Player, Bacteria, Medicinal Plant, Mentha, Antibacterial Activity, Antioxidant Activity https://www.ijper.org/article/51/3s1/s221-s224 2026-04-13T05:55:19.84398+00:00 Antimicrobial Activity and Chemical Composition of Coriander & Galangal Essential Oil 2017-07-14 10.5530/ijper.51.3s.17 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-221.pdf Essential oils were obtained from Coriandrum sativum and Alpinia officinarum through steam distillation method in this study. Antimicrobial activities of the obtained essential oils were investigated by using minimum inhibitory concentration (MIC) test by against 18 different species microorganisms. It was found that the C. sativum had strong antimicrobial activities against the 14 tested microorganism and A. officinarum oils showed strong antimicrobial activity against the 7 tested microorganis C. sativum, A. officinarum, Essential oil, GC-MS, Antimicrobial activity https://www.ijper.org/article/51/3s1/s195-s199 2026-04-13T05:55:19.84398+00:00 Genetic Diversity of Local Endemic Teucrium leucophyllum Montbret & Aucher ex Bentham. (Lamiaceae) in Turkey 2017-07-14 10.5530/ijper.51.3s.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-195.pdf Background and Objective: Teucrium leucophyllum is endemic plant species having considerable narrow distribution in Erzincan (Turkey) Region. The aim of this study was to determine genetic diversity levels of T. leucophyllum in order to obtain data for its conservation. Method: Genomic DNA was isolated from 81 plants using CTAB method. Genetic diversity in four natural populations of T. leucophyllum was investigated by ISSR markers. A binary matrix was produced by scoring each amplified fragment Genetic diversity, ISSR, PCR, Teucrium leucopyllum, Endemic plant https://www.ijper.org/article/51/3s1/s262-s267 2026-04-17T09:59:38.317336+00:00 Effect on Histology and Nutrient Digestibility of Supplemented Origanum onites Essential Oil to Rainbow Trout Diets (Oncorhynchus mykiss) 2017-07-14 10.5530/ijper.51.3s.26 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-262.pdf The present experiment was conducted to describe the effects on histology (experiment 1) and nutrient digestibility (experiment 2) of rainbow trout fed with diet containing O. onites oil. Diets were prepared with supplemented in different concentrate (0, 0.125, 1.5, 2.5, 3.0 ml kg-1) of O. onites oil. A total of 1050 trout (body weight 26.05 ± 0.15 g) were randomly stocked into 15 tanks. The experiments were done in triplicate. In the experiment 1, rainbow trout were fed during 90 day for histol Origanum onites, Rainbow trout, Nutrient digestibility, Oregano, Histology https://www.ijper.org/article/51/3s1/s159-s162 2026-04-13T05:55:19.84398+00:00 The Effects of Ginger Extract and Diazepam on Anxiety Reduction in Animal Model 2017-07-14 10.5530/ijper.51.3s.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-159.pdf Objective: Anxiety disorders are from common disorders of human. Drug treatments have side effects, and searching new ways with fewer side effects is inevitable. Ginger is a medicinal plant with many therapeutic effects. Methods: In current study the effects of ginger extract and diazepam on anxiety reduction of laboratory mice were investigated. Sixty female mice (25-30g) were divided into six groups including control, anxiety, diazepam and 50, 100 and 200 mg/kg extract doses. After receiving t Ginger, Anxiety, Diazepam, Plus elevated maze, Mice https://www.ijper.org/article/51/3s1/s148-s151 2026-04-17T09:43:13.2276+00:00 Nutraceuticals for Healthy Life 2017-07-14 10.5530/ijper.51.3s.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3s1-148.pdf The lifestyle has improved with economic development of the people. Side by side the major challenge are `lifestyle diseases’ that are due to food habits. Consumption of junk food has increased manifold, which has led to a number of diseases related to nutritional deficiencies. Hence they are shifting from synthetic ingredients towards organic foods and ingredients, which are obtained from natural sources. Of late, Nutraceuticals can play an important role in controlling them and also fulfill al nutraceutical, functional food, functional food https://www.ijper.org/article/51/3/365-372 2026-04-17T09:16:55.779574+00:00 A Management and Special Pharmacy Services course for pharmacy students 2017-06-22 10.5530/ijper.51.3.62 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3-365.pdf Purpose: To describe the designing and implementation of a Management and Special Pharmacy Services course. Methods: According to the typology of teaching activity established by the Ministry of Higher Education of Cuba a course was designed. The course was focus on the development and management of innovative practices in all areas of pharmacy practice. To assess the students’ perceptions related to the course a 9-item survey was distributed to 25 students. Results: All students returned the su Pharmacy Management Education, Pharmaceutical Care, Social Pharmacy, Pharmacy Education, University https://www.ijper.org/article/51/3/412-417 2026-04-17T09:27:11.355942+00:00 Effects of Rutin on Testicular Antioxidant Enzymes and Lipid Peroxidation in Rats 2017-06-22 10.5530/ijper.51.3.69 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3-412.pdf Background: Rutin, a polyphenolic flavonoid, possesses antioxidant and hypoglycemic effects. Objective: The present study was conducted to check the effect of rutin on serum reproductive hormonal level and sperm concentration in male rat. Methods: 30 rats were equally divided into 3 groups (10 rats per group). Group I was control (untreated), group II was given rutin 50 mg/kg bw while group III was given 100 mg/ kg bw intragastric twice a week for four weeks respectively. The effect of rutin on Rutin, TBARS contents, Antioxidant enzymes, Flavonoids, Catalase https://www.ijper.org/article/51/3/461-471 2026-04-17T09:33:02.583524+00:00 Effect of Leaves of Vitex. trifolia Linn on Different Stages of Inflammation 2017-06-22 10.5530/ijper.51.3.74 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3-461.pdf Objective: The objective of the study was to evaluate effect of hydroalcoholic extract of V.trifolia Linn for anti-inflammatory activity. Methodology: Wistar rats weighing 150-200 g were used divided into four groups which were treated with the plant extracts and with indomethacin as standard drug. Acute inflammation was produced by injecting 0.1 mL of 1% homogenized carrageenan suspension in normal saline to the left hind paw of the rats. Paw volume measured using a digital plethysmometer. Sub- V.Trifolia; Acute Inflammation, Sub-Acute Inflammation, Anti-Inflammatory Activity https://www.ijper.org/article/51/3/480-489 2026-04-17T09:35:20.30679+00:00 In vitro Antimicrobial Investigations of Newly Synthesized Transitional Bivalent Metal Complexes Derived from 8-Hydroxyquinoline 2017-06-22 10.5530/ijper.51.3.76 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3-480.pdf Introduction: Novel Cu(II), Co(II) and Ni(II) complexes of 8-hydroxyquinolineazo analogues are synthesized from 5-((3-nitrophenyl)diazenyl) quinolin-8-ol (4a) and 5-((4-bromo-3- methylphenyl) diazenyl) quinolin-8-ol (4b). Methods: The structural environment and elemental composition of the synthesized metal complexes are confirmed by FT/IR, 1H NMR and CHNS/O elemental analyzer. The λmax and molecular mass are determined with the help of UV-visible and LC-MS spectrometer. Results: The magnetic su Spectroscopic, Magnetic susceptibility, Antimicrobial, 8-Hydroxy quiniline, Antibiogram https://www.ijper.org/article/51/3/355-364 2026-04-17T09:15:20.940823+00:00 Training of Novice Researchers: A Study on the Outcomes and Benefits of Using the Problembased Laboratory Approach as an Alternative in the Pharmacy Curriculum 2017-06-22 10.5530/ijper.51.3.61 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3-355.pdf The objective of this research is to study the outcomes and benefits of using the Problem- Based Laboratory (PBLab) approach as an alternative to the traditionally-practised, supervisor-based research projects; in essence, the PBLab approach aims at finding out if the new approach can enhance or improve students’ research experiences, capabilities and leadership qualities when they conduct a research-oriented project in a group. A group of five students in the second year Diploma in Pharmacy pro Problem-based laboratory, Research, Curriculum, Pharmacy, Facilitator https://www.ijper.org/article/51/3/472-479 2026-04-17T09:33:37.646074+00:00 GC-MS Analysis of Young Leaves of Allophylus cobbe (L.) Raeusch. and Allophylus serratus (Roxb.) Kurz. 2017-06-22 10.5530/ijper.51.3.75 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3-472.pdf Background: Allophylus cobbe(L.) Raeusch. and Allophylus serratus (Roxb.)Kurz. (Sapindaceae) are medicinal plants traditionally used to cure bone fractures and other ailments in India. Objective: Present work was aimed at the identification of phytochemical compounds from young leaves of A. cobbe and A. serratus by applying gas chromatography mass spectrometry. Method: GC-MS technique was used for analysis of compounds. Results: It indicates 11 compounds from A. serratus and seven compounds from GC-MS Analysis, Allophylus Cobbe, Allophylus Serratus, Young Leaves, phytol, medicinal plants https://www.ijper.org/article/51/3/401-406 2026-04-17T09:25:11.283275+00:00 The Release of Doxorubicin’s Active Ingredient from the Hydrogels with Poly (HEMA/Acrylamide/ Itaconic acid) and Their Biological Function 2017-06-22 10.5530/ijper.51.3.67 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3-401.pdf In this study, Poly (HEMA/Acrylamide/ Itaconic acid) (HAI) polymer was synthesized for using in the release of Doxorubicin drug. Poly (HEMA/acrylamide/Itaconic acid) (HAI) hydrogel was prepared by a radical addition reaction in aqueous media formed by HEMA, acrylamide, Itaconic acid, in the presence of TEMED (N,N,N’,N’-tetramethylenediamine). The characterization of the polymer was performed by FTIR analysis. At the same time, swelling and drug absorption capabilities of the polymers were analyz Doxorubicin, Poly (HEMA/acrylamide/Itaconic acid), Drug release, FTIR, kinetix https://www.ijper.org/article/51/3/452-460 2026-04-13T05:55:20.550558+00:00 Design and Synthesis of Novel Indolizine Analogues as COX-2 Inhibitors: Computational Perspective and in vitro Screening 2017-06-22 10.5530/ijper.51.3.73 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3-452.pdf Design and synthesis of a new series of ethyl 7-methoxy-2-substituted-3-(substituted benzoyl) indolizine-1-carboxylates 2a-i was achieved and screened for their in vitro inhibitory activity against COX-2 enzyme. Compound 2a and 2c emerged as promising COX-2 enzyme inhibitor with IC50 of 6.56 and 6.94 μM respectively from the synthesized series when compared to Celecoxib and Indomethacin as selective and nonselective standards, respectively. Computational docking study identified the possible rea Cox-2 Inhibition, Indolizine Analogues, Synthesis, Characterization, Molecular, Docking https://www.ijper.org/article/51/3/407-411 2026-04-13T05:55:20.550558+00:00 Sub-cellular localization of Tetrodotoxin in the Tissues of the Pufferfish Takifugu Oblongus 2017-06-22 10.5530/ijper.51.3.68 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3-407.pdf Objective: The prime objective of this study is to determine the origin of Tetrodotoxin in the pufferfish Takifugu oblongus. Methods: Ultracentrifugation was performed to separate the tissues into various cellular fractions. Mouse bioassay was done to analyse the toxicity of different fractions from skin, liver and ovary of T. oblongus. The toxic fractions were subjected to HPLC-UV detection, to detect the presence of tetrodotoxin and quantify it. Results: Cytosolic fractions of skin, liver and Takifugu oblongus, Tetrodotoxin, Ultracentrifugation, Mouse Bioassay, HPLC https://www.ijper.org/article/51/3/418-426 2026-04-13T05:55:20.550558+00:00 Therapeutic Effect of Hydro-Ethanolic Extract of Pothos scandens L on key Carbohydrate Metabolizing Enzymes and Xenobiotic Marker Enzymes in DMBA Induced Experimental Mammary Carcinoma 2017-06-22 10.5530/ijper.51.3.70 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3-418.pdf Objective: In the present study, phytochemical evaluation and the therapeutic effect of 50 % hydro-ethanolic extract of aerial parts of Pothos scandens (HEEPS) on glycolytic enzymes, TCA cycle enzymes, gluconeogenic enzymes and xenobiotic marker enzymes in the liver and breast tissues of 7, 12 -Dimethylbenz [a] anthracene (DMBA) induced breast cancer bearing rats were carried out. Materials and Methods: Five groups of (each group six rats) female albino Spargue-Dawley rats were taken. Group I (c Pothos scandens L, GC-MS, 7, 12 -Dimethylbenz [a] anthracene (DMBA), Mammary Carcinoma, Carbohydrate Metabolizing Enzymes, Xenobiotic Markers https://www.ijper.org/article/51/3/436-451 2026-04-13T05:55:20.550558+00:00 SWFB and GA Strategies for Variable Selection in QSAR Studies for the Validation of Thiazolidine- 2,4-Dione Derivatives as Promising Antitumor Candidates 2017-06-22 10.5530/ijper.51.3.72 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3-436.pdf Objective: Thiazolidine-2,4-dione (TZD) are the well known anti-diabetic scaffold. Very recently, several TZD based anti-cancer agents have came into limelight for treating mutant cancer forms. In order to establish and understand the relationship of biological activity with that of physiochemical parameters associated with the structure, twodimensional (2D-QSAR), group-based (G-QSAR), and three-dimensional (3D-QSAR) were performed which may be useful for (medicinal) chemists in selecting the mo G-QSAR, kNN-MFA, Thiazolidine-2, 4-dione, 2D/3D QSAR, VLife MDS https://www.ijper.org/article/51/3/393-400 2026-04-17T09:23:48.663282+00:00 Artemisinin Reduces Lipid Accumulation in Hepatocytes by Inhibition of CD36 Expression 2017-06-22 10.5530/ijper.51.3.66 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3-393.pdf Background: Artemisinin, a kind of sesquiterpene lactone endoperoxide, is isolated from Artemisia annua., has been used to effectively treat different forms of malaria. Recently, some researchers showed that artemisinin decreased serum triacylglycerol in rats. However, the molecular mechanism remains unclear. Aim: In this study, we investigated the effect of artemisinin on lipid accumulation in an in vitro model of NAFLD. Methods: The cytotoxicity of OA and artemisinin on SMMC-7721 cells was mea Artemisinin, CD36, Hepatic lipid accumulation, NAFLD, SMMC-7721 Cells https://www.ijper.org/article/51/3/388-392 2026-04-13T05:55:20.550558+00:00 Applications of New Validated RP-HPLC Method for Determination of Indomethacin and its Hydrolytic Degradants using Sodium Acetate Buffer 2017-06-22 10.5530/ijper.51.3.65 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3-388.pdf Objective: A New RP-HPLC method for estimation of indomethacin and its two degradant impurities 4-chlorobenzoic acid, 5-methoxy-2-methyl-indoleacetic acid was developed and validated as per ICH guidelines. Background: This new method is not only capable of identifying and quantifying the impurities but also can be used for the assay of indomethacin in marketed capsule formulations. Methods: The chromatographic conditions were optimized using Zorbax Eclipse Plus C18, 3.5 μm (4.6 mm × 100 mm) colu RP-HPLC, Indomethacin, 4-chlorobenzoic acid, 5-methoxy-2-methylindoleacetic, acid, Validation https://www.ijper.org/article/51/3/490-501 2026-04-13T05:55:20.550558+00:00 Synthesis, Characterization and Antimicrobial Activity of some Metal Complexes Derived from Thiazole Schiff Bases with In-vitro Cytotoxicity and DNA Cleavage Studies 2017-06-22 10.5530/ijper.51.3.77 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3-490.pdf Five metal complexes with Schiff-base ligand, 3-((4-phenylthiazol-2-ylimino) methyl)-2- hydroxybenzoic acid were synthesized with metal ions such as Cu(II), Co(II), Ni(II), Cd(II) and Zn(II). The reaction likely proceeds via condensation of 2-amino-4-phenyl thiazole with 3-aldehydosalicylic acid and characterized by elemental analysis and various spectral studies like FT-IR, 1H NMR, ESI mass, and TGA/TDA and molar conductance studies. The spectral results revealed bidentate O-O donor and forms t Thiazole, Schiff base, Antimicrobial, DNA cleavage, In-vitro cytotoxicity https://www.ijper.org/article/51/3/380-387 2026-04-13T05:55:20.550558+00:00 Validation and Evaluation of an OSCE in Undergraduate Doctor of Pharmacy Program 2017-06-22 10.5530/ijper.51.3.64 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3-380.pdf Introduction and purpose: In schools not performing OSCE method, faculty members’ lack of time, human resources and managing the complexity of such exam are the most common obstacles. In this study, we utilized different methods to evaluate the the validity and reliability of a simple diversified OSCE as part of final exam for ambulatory care clerkship along with the theoretical exam. Methods: We analyzed the correlation and difference between students’ achievements in the written exam and their OSCE, Doctor of Pharmacy, ambulatory care clerkship, clinical skills, written, exam https://www.ijper.org/article/51/3/427-435 2026-04-13T05:55:20.550558+00:00 Influence of Demographic Location and Solvent Extraction on Pharmacognostical Assessment and Identification of Conessine Content in Different Parts of Holarrhena antidysentrica Through HPTLC Analysis 2017-06-22 10.5530/ijper.51.3.71 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3-427.pdf Objective: The present study is aimed at comparative pharmacognostical studies in terms of macroscopic and quantitative microscopy on different solvent (chloroform, methanol and water) extracted leaves, stem and root parts of HA, procured from the Bangalore soil zone, Karnataka, India. Methods: Initially the soil parameters are checked for the presence of various metals and other physicochemical properties. Microscopy and macroscopic analysis were performed to under the arrangement of anatomical Holarrhena antidysentrica, HPTLC, preliminary evaluation, solvents https://www.ijper.org/article/51/3/373-379 2026-04-17T09:18:19.904155+00:00 Pharmacy Students’ Experiences, Preferences and Perceptions on Online Assessment 2017-06-22 10.5530/ijper.51.3.63 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-3-373.pdf Introduction: As online education becomes more popular so does online assessment. Objectives: The aims of this study are to determine the students’ experiences, preferences and perceptions of the online assessment. Methodology: The instrument consists of a selfanswered 45 items questionnaire. The online assessments refer to quizzes and tests from any of the courses listed in the academic plan and conducted using the i-learn platform. Data was collected from 248 students of Bachelor of Pharmacy ( Online assessment, Pharmacy students, Preferences, Perceptions, Experiences https://www.ijper.org/article/51/2s/s8-s16 2026-04-13T05:55:21.312614+00:00 Development and Validation of Stability Indicating HPTLC Method for the Determination of Metformin Hydrochloride and Benfotiamine in Bulk and Combined Dosage Form 2017-04-14 10.5530/ijper.51.2s.44 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2s-8.pdf Context: A Simple, selective, precise, and Stability indicating High Performance Thin Layer Chromatography (HPTLC) method of analysis of Metformin Hydrochloride (MET) and Benfotiamine (BENT) both as a bulk drug and in their combined formulation has been developed. Method: The basic aim of this method is to separate both the drugs by HPTLC and measure their spots at 249 nm. The separation was carried out on TLC aluminium sheets of silica gel 60F 254 using Benzene: Methanol: Triethylamine (8.5:1:0 HPTLC, MET, BENT, Method validation, Forced Degradation, Stability, Indicating https://www.ijper.org/article/51/2s/s69-s78 2026-04-13T05:55:21.312614+00:00 Formulation and Evaluation of Carbamazepine Liquisolid Compacts Using Novel Carriers 2017-04-14 10.5530/ijper.51.2s.52 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2s-69.pdf Objective: The aim of present investigation was to prepare liquisolid compacts of high dose water insoluble drug, carbamazepine (CBZ) using novel porous carriers such as Neusilin and Fujicalin in order to improve its dissolution rate and reduce the tablet weight. Materials and Methods: Solubility of CBZ was determined in different non volatile solvents to finalise vehicle having maximum solubility. The liquid retention potential (ф) of carriers and coating material was determined and 18 differen Avicel, Carbamazepine, Dissolution enhancement, Fujicalin, Liquisolid, compact, Neusilin https://www.ijper.org/article/51/2s/s122-s128 2026-04-13T05:55:21.312614+00:00 2D and 3D QSAR of Benzimidazole Analogues as Novel HIV-1 Non Nucleoside Reverse Transcriptase Inhibitors 2017-04-14 10.5530ijper.51.2s.58 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2s-122.pdf Context: Acquired Immuno Deficiency Syndrome (AIDS) is a viral disease caused by Human Immunodeficiency Virus. There is an urgent need to identify newer NNRTIs active against these mutant strains Literature survey has revealed that N1-aryl-benzimidazole analogues have significant potential as HIV-1. Aim: Pharmacophore optimization of Benzimidazole nucleus as non-nucleoside reverse transcriptase inhibitors using Two Dimensional (2D) and Three Dimensional (3D) QSAR. Material & Method: Studies were Molecular Modeling, 2d Qsar, 3d Qsar, Benzimidazole, Anti –HIV https://www.ijper.org/article/51/2s/s98-s109 2026-04-17T09:06:34.749777+00:00 Insilico Design, Synthesis of Hybrid Taurine Amino Acid and Peptide Analogues for Studies on Antioxidant and Hepatoprotective Activity 2017-04-14 10.5530/ijper.51.2s.55 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2s-98.pdf Introduction: The liver performs normal metabolic homeostasis of the body as well as biotransformation, extraction and detoxification of many compounds. Due to this it is more susceptible to disease. Near about 900 drug are withdraw from the market due to hepaptoxicity. The objective of the work to synthesis the series of hybrid taurine amino acid and peptide analogues in which the various combinations of taurine amino acid, Di-peptide and Tri- peptide were synthesized. Aims: In this study, we m Taurine, Peptides, Cyp2e1, Antioxidant, Hepatoprotection https://www.ijper.org/article/51/2s/s54-s60 2026-04-13T05:55:21.312614+00:00 Influence of Light Through Optical Glasses on Electroencephalogram 2017-04-14 10.5530/ijper.51.2s.50 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2s-54.pdf Background: In General, optical powered glasses are used to have good focus and clear vision. But, this practice may also bring noticeable variation in light intensity which in turn affects neural behavior. These changes can be interpreted from the EEG recordings. Thus, in this present study, the grounds for amendments in different physiological variables due to light intensity through optical glasses experienced by the subject have been reviewed and verified. Experiment: Changes in light intens Electroencephalogram, Light, Light Dependent Resistor, Optical glass, Neurophysiology https://www.ijper.org/article/51/2s/s17-s23 2026-04-13T05:55:21.312614+00:00 Development and Evaluation of Internal and External Predictability of Metoclopramide Hydrochloride Modified Release Formulations: An Establishment of Level A In vitro and In vivo Correlation 2017-04-14 10.5530/ijper.51.2s.45 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2s-17.pdf The objective of this study was to develop an in vitro–in vivo correlation (IVIVC) model for hydrophilic matrix sustained-release (SR) Metoclopramide formulations. The in vitro release characteristics of the drug were determined using USP apparatus II at 50 rpm, pH 6.8. In vivo plasma concentrations and pharmacokinetic parameters in healthy human subjects were obtained after administering oral dose, developed SR formulations and marketed immediate-release (IR) products. The similarity factor f2 Metoclopramide Hydrochloride, Modified Release, Level A Correlation, Internal, And External Prediction Errors https://www.ijper.org/article/51/2s/s91-s97 2026-04-17T09:05:40.566913+00:00 Optimization of Monolayer Hydrophilic Matrix Tablets Containing Nisoldipine Solid Dispersion Using D-optimal Design 2017-04-14 10.5530/ijper.51.2s.54 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2s-91.pdf Background: Nisoldipine (NIS) is a BCS-class II drug with a low oral bioavailability (~5%). The popular marketed product is a trilayer Geomatrix® system. Although it provides for drug release control of NIS, a trilayer matrix system is a complex design, which is difficult to manufacture on an industrial scale using conventional press. The present study discusses an alternate approach to improve drug dissolution using solid dispersion (SD) method followed by design of a simple monolayer controlle Nisoldipine, Solid Dispersion, Design of Experiments, Screening, Mixture, Design https://www.ijper.org/article/51/2s/s129-s135 2026-04-17T09:10:22.634301+00:00 The impact of Clinical Pharmacist Lead Collaborative Care on Quality Of Life of the Patients with Bipolar Disorder: A Unicenter Prospective, Randomization Study 2017-04-14 10.5530/ijper.51.2s.59 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2s-129.pdf Background: Bipolar disorder is a chronic mental illness, characterized by the presence of manic, depressive and cyclic episodes, usually separated by asymptomatic intervals. Illness significantly affects the patients’ quality of life. Hence, clinical pharmacists can contribute to managing the disease condition of the patients, mainly with the use of effective and safe drugs, and improve the patient’s quality of life through pharmaceutical care. Methods/design: A Randomized, interventional, pros Quality Of Life, Bipolar Disorder, Pharmaceutical Care, Mania, Depression, Psycho-Education, Clinical Pharmacist https://www.ijper.org/article/51/2s/s110-s114 2026-04-17T09:07:16.268282+00:00 Protective Effect of Aerva jevanica Against Ethanol Induced Hepatic Stress in Rats: A Randomized Control Report 2017-04-14 10.5530ijper.51.2s.56 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2s-110.pdf Background: Aerva jevanica (AJME) possess antioxidant activity and hepatoprotective effects, and traditionally in Pakistan for liver diseases. Methods: 24 male albino rats were divided into five groups of 4 chicks of each, having free access to food and water. Group I (control) while group II, III and IV were treated with ethanol 24 hrs for 2 weeks. Rats group II received only ethanol group III received silymarin at a dose of 50 mg/kg while group IV was given AJME (200 mg/kg). The activities of Aerva Jevanica, Ethanol, Liver, Antioxidant Enzymes, Lipid Peroxidation https://www.ijper.org/article/51/2s/s136-s146 2026-04-13T05:55:21.312614+00:00 Tamarind Seed Polysaccharide: An Emerging Excipient for Pharmaceutical Use 2017-04-14 10.5530/ijper.51.2s.60 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2s-136.pdf Currently, various plant polysaccharides have been studied for their diverse applications as excipients like binders, granulating agents, disintegrants, emulsifiers, suspending agents, gelling agents, mucoadhesive agents, matrix-formers, release retardants, enteric resistants, etc., in various pharmaceutical dosage forms. Among these, tamarind seed polysaccharide is an emerging excipient, which is beingused and investigated for the preparation of various dosage forms like suspensions, emulsions, Tamarind Seed Polysaccharide, Excipient, Drug Delivery, Sustained Drug, Release https://www.ijper.org/article/51/2s/s61-s68 2026-04-13T05:55:21.312614+00:00 Development of Stability Indicating TLCDensitometry Method of Edaravone Using QbD Approach: Degradation Kinetic Study 2017-04-14 10.5530/ijper.51.2s.51 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2s-61.pdf Objective: The objective of present method was to utilize risk based and systematic Quality by design approach for development of selective, sensitive, precise, accurate and robust stability-indicating TLC-densitometry for quantification of Edaravone and its degradation products. Method: The TLC-densitometric analysis was carried out in the absorbance mode at 244 nm using solvent system petroleum ether: ethyl acetate: glacial acetic acid (6ml:4ml:10μl v/v/v). This system was found to give compac Edaravone, CNX approach, QbD, SIAMs, TLC-densitometry https://www.ijper.org/article/51/2s/s79-s90 2026-04-13T05:55:21.312614+00:00 Elaboration of Microspheres’ Capsules Based on Ethylcellulose and Synthesized Poly (Butylsuccinate) as Biodegradable Matrices for Drug Delivery of an Antithyroidian Agent 2017-04-14 10.5530/ijper.51.2s.53 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2s-79.pdf Introduction: The present paper provides details of preparation of hardcapsules based on microspheres containing 2-aminothiazole as an antithyroidian agent and synthesized poly(butylsuccinate) (PBS) or ethylcellulose(EC10) as biodegradable matrices as well as the study of the drug delivery. Methods: A disintegration tests of these gelatinous capsules were done. The biodegradable synthesized polyester was characterized by infrared spectroscopy, nuclear magnetic resonance (mono and bidimentional H Antithyroidian agent, Microspheres, Biodegradable polymer matrix, Capsules, Drug release, Kinetic study https://www.ijper.org/article/51/2s/s40-s45 2026-04-17T08:58:20.378378+00:00 In situ cross Linked Chitosan-Gellan Gum Polyelectrolyte Complex Based Nanogels Containing Curcumin for Delivery to Cancer Cells 2017-04-14 10.5530/ijper.51.2s.48 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2s-40.pdf Objective: The objective of this study is to prepare nanogels were prepared via ionic complexation with negatively charged gellan gum. Method: Nanogel of curcumin was prepared by in situ cross linking reaction between two oppositely charged materials by green method without use of chemical cross linking agents. The prepared nanogels were characterized by Dynamic light scattering, scanning electron microscopy, differential scanning calorimetry and X- Ray diffractometry. Results: The prepared form Nanogel, Chitosan, Gellan gum, Curcumin, Cancer https://www.ijper.org/article/51/2s/s1-s7 2026-04-17T08:55:21.169721+00:00 Variation in Total Polyphenolic Contents, DNA Protective Potential and Antioxidant Capacity from Aqueous and Ethanol Extracts in Different Plant Parts of Hypericum perforatum L. 2017-04-14 10.5530/ijper.51.2s.43 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2s-1.pdf Background and Purpose: Hypericum perforatum belonging to the family Hypericaceae is a reputed medicinal plant including a wide ranges of important phytochemical components. Chlorogenic acid, rutin, hyperoside, quercitrin, quercetin, pseudohypericin, hypericin and hyperforin are of the major components. Crude extract and individual compounds of H. perforatum have been reported to exert antidepressant, antibiotic, and antitumoral activities. It is worthy to note that the quantity and efficacies o Antioxidant, DNA protective activity, Flavonoid, Hypericum perforatum L, Phenolic https://www.ijper.org/article/51/2s/s46-s53 2026-04-17T09:00:05.062733+00:00 Optimization and in-vitro Evaluation of Poly (lactic acid) /Mesalazine Microspheres as Drug Carriers 2017-04-14 10.5530/ijper.51.2s.49 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2s-46.pdf Purpose: The present study is intended to the preparation and optimization of controlled drug release microparticles based on polylactic acid and Mesalazine. This active ingredient is usually used in the therapy of intestine inflammatory diseases, particularly the Crohn’s disease and hemorrhagic recto colitis. Methods: Microencapsulation by simple O/W emulsion solvent evaporation method was used to prepare these formulations. Some of the process variables such as the emulsifier concentration, th Microencapsulation, Polylactic acid, Mesalazine, Microparticles, Process, variables, Optimization https://www.ijper.org/article/51/2s/s24-s33 2026-04-17T08:56:45.473461+00:00 GC-MS Analysis of Bioactive Compounds and Hosttoxicity Studies of Azolla caroliniana Symbiotic with the Cyanobacterium Anabaena azollae 2017-04-14 10.5530/ijper.51.2s.46 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2s-24.pdf Objective: The present research work was conducted to do the gas chromatography and mass spectrometry (GC-MS) analysis of the water fern, Azolla caroliniana symbiotic with the cyanobacterium Anabaena azollae, along with in vitro host toxicity testing to check its toxicity level. Materials and methods: The GC-MS analysis of the methanol extract of A. caroliniana was carried out using a GC-MS instrument and in vitro host toxicity testing of A. caroliniana extract was carried out with cultured lymp Azolla caroliniana, Fern, Gc-Ms Analysis, 3-O-Methyl-D-Glucose, Host, Toxicity Testing, In Vitro Cultured Lymphocytes https://www.ijper.org/article/51/2s/s115-s121 2026-04-13T05:55:21.312614+00:00 A Validated Method Development for Quantification of Pravastatin Sodium using Diffuse Reflectance Fourier Transform Spectroscopy 2017-04-14 10.5530ijper.51.2s.57 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2s-115.pdf Objective: The plan of the proposed work is development and validation of a new, simple and cost- effective method using Diffuse Reflectance Fourier Transform Infrared Spectroscopy as a method of choice for analysis of Pravastatin in the solid dosage forms. Method: Spectrum using Fourier transform infrared (DRS 8000) was analyzed after preparing solid state sample through diluting in dry potassium bromide. The method was validated according to the International conference on Harmonization guidel Pravastatin Sodium, Validation, Diffuse Reflectance Infrared Fourier Transform, Spectroscopy, Fourier Transform Infra Red Spectroscopy, International Conference on, Harmonization Guidelines, Method Development https://www.ijper.org/article/51/2s/s34-s39 2026-04-17T08:57:41.904006+00:00 Aluminium-Eriochrome Cyanin R, A Novel Chromogen for the Spectrophotometric Determination of Pentoprazole Sodium 2017-04-14 10.5530/ijper.51.2s.47 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2s-34.pdf A Spectrophotometric method for the determination of pentoprazole sodium in bulk and pharmaceutical formulations was developed by the authors. The method is based on the color reaction between the sample solution of the drug and a solution of aluminiumeriochrome cyanin R. the reagent was found to be unique and novel in the detection and determination of the drug. A reddish purple color solution is the resultant of the reaction between the drug and the reagent. This reddish purple colored product Pentoprazole Sodium, Eriochrome Cyanin R, Spectrophotometry, Pharmaceutical, Formulations, Aluminium Chloride https://www.ijper.org/article/51/2/329-336 2026-04-13T05:55:23.103709+00:00 GC-MS Analysis and Antibacterial Activity of Aerial Parts of Quisqualis indica Plant Extracts 2017-03-13 10.5530/ijper.51.2.39 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2-329.pdf Background: Bacteria is an important group of human pathogens that causes various types of diseases. Plants are the traditional sources for many chemicals used as pharmaceutical biochemicals, fragrances, food colors and flavors in different countries especially in India. Quisqualis indica Linn. belongs to a family Combretaceae which is commonly known as Rangoon creeper has great medicinal values. Objective: To analyze the chemical constituents present in different solvent extracts of Q. indica u Antibacterial activity, GC-MS analysis, Phytochemicals constituents, Quisqualis indica https://www.ijper.org/article/51/2/207-215 2026-04-17T06:56:48.575204+00:00 A Test Adaptation of the Modified Readiness for Inter-professional Learning Scale in Turkish 2017-03-13 10.5530/ijper.51.2.26 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2-207.pdf Background: There is a need for healthcare professionals to develop teamwork and collaboration skills before they graduate. Inter-professional education is a suitable modality for these learning outcomes and it will be effective if it begins early in the undergraduate curriculum. Objectives: “Inter-professional Collaboration for Patient Safety” has been taught as an elective course in Hacettepe University. This new educational modality requires measuring tools to determine the qualifications of Inter-professional Learning, Readiness, Reliability, Validity, Scale Adaptation https://www.ijper.org/article/51/2/295-301 2026-04-17T08:38:54.553622+00:00 Investigation and Characterization of Maghemite (γ-Fe2O3) Nanoparticles and Its Cytotoxicity Studies 2017-03-13 10.5530/ijper.51.2.35 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2-295.pdf Objective: The expansion of wet chemical method for the synthesis of iron oxide nanoparticles with magnetic properties is reported. Methods: Iron oxide nanoparticles were investigated in the procedure using Transmission Electron Microscopy (TEM). It has been seen that the distribution size changed by changing of Molarity precursor and heating the sample. The magnetization evaluations were performed using a Vibrating Sample Magnetometer device (VSM) to specify the magnetic answer. The Thermo Grav Magnetic properties, Maghemite, Iron oxide nanoparticles, Cell viability, Cytotoxicity https://www.ijper.org/article/51/2/192-206 2026-04-13T05:55:23.103709+00:00 Migration Trends of Pharmacy Students of Pakistan: A Study Investigating the Factors Behind Brain Drain of Pharmacy Professionals from Pakistan 2017-03-13 10.5530/ijper.51.2.25 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2-192.pdf Background: Pakistan has witnessed a rise in the migration of professionals from the country in the last few years eventually leading to a brain drain. It is believed that the pharmacy students of Pakistan are ingrained with migration tendency. This study aimed to find out the factors influencing the trend, country of choice and reasons for migration. The study also looked into hurdles anticipated by the students during and after migration. Methods: A cross sectional study of 5 month duration wa Migration, Brain drain, Pharmacy, Students, Pakistan, Human migration, Pharmacy education, Pharmacy practice https://www.ijper.org/article/51/2/226-238 2026-04-17T06:58:46.7919+00:00 Opportunities and challenges for Indian Pharmaceutical companies in overseas markets and need of digital tools for sustainable success 2017-03-13 10.5530/ijper.51.2.28 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2-226.pdf Background: The era of globalization has helped many Indian Pharma companies to expand operations beyond home turf. Changes in regulatory, patent and market trends will drive opportunities for generic drugs and hence very big opportunities for Indian pharmaceutical companies in global markets. India is the largest manufacturer and exporter of generic drugs in the world and considered as the pharmacy of the world. However many Indian pharma companies find it difficult to survive in global markets Indian pharma industry, Digital tools, Global markets, Globalization, Digital, strategy, Automation in pharma, Pharma domain https://www.ijper.org/article/51/2/270-279 2026-04-17T07:03:36.819456+00:00 Alginate-chitosan Coated Lecithin Core Shell Nanoparticles for Curcumin: Effect of Surface Charge on Release Properties and Biological Activities 2017-03-13 10.5530/ijper.51.2.32 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2-270.pdf Alginate-chitosan coated lecithin nanoparticles loaded with Curcumin have been prepared by layer deposition of alginate on lecithin/chitosan nanoparticles and were characterized. The prepared nanoparticles were physicochemically characterized to ensure alginate coating. The encapsulation efficiency and loading of the active nutraceutical were assessed using spectrophotometric measurements. The biological activities of the prepared nanoparticles were assessed by membrane stabilization effect of t Layer deposition, Membrane stabilization, MTT assay, Membrane stabilization, Biocompatibility https://www.ijper.org/article/51/2/169-176 2026-04-13T05:55:23.103709+00:00 Ayurvedic Liquid Dosage form Asava and Arista: An Overview 2017-03-13 10.5530/ijper.51.2.22 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2-169.pdf Introduction: Ayurveda, the science of life, has a strong heritage in India and is being practised for last several thousand of years for treating various ailments. Asava and arista are considered as unique dosage forms of Ayurveda due to their indefinite shelf life. The self generated alcohol in these preparations potentiates the products pharmaceutically and therapeutically. Objectives: These asava and arista preparations are popular since the Samhita period due to their better absorption, qui Asava-Arista, Historical prospective, Methods of preparation, Parameters https://www.ijper.org/article/51/2/321-328 2026-04-13T05:55:23.103709+00:00 Anti-Hepatotoxic and Antioxidant Activity of Limnanthemum indicum Against Carbon Tetrachloride Induced Liver Toxicity in Rats 2017-03-13 10.5530/ijper.51.2.38 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2-321.pdf Objective: Whole plant of Limnanthemum indicum (Menyanthaceae) is traditionally used for liver disorders. Limnanthemum indicum was investigated for its Anti-hepatotoxic and Antioxidant activity. Materials and Methods: Alcoholic extract of whole plant of Limnanthemum indicum (100, 200, 400 mg/kg, p.o.) was evaluated for its Anti-hepatotoxic and Antioxidant activity in Carbon tetrachloride (CCl4)-induced liver toxicity in Rats. The Anti-hepatotoxic activity was assessed from biochemical and histop Carbon tetrachloride, Hepatoprotective, Limnanthemum indicum, Antioxidant, Alcohoic extract, histopathology https://www.ijper.org/article/51/2/343-348 2026-04-13T05:55:23.103709+00:00 Simultaneous Determination of Sartans by High Performance Liquid Chromatography with Ultra Violet Detection 2017-03-13 10.5530/ijper.51.2.41 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2-343.pdf Objective: A high performance liquid chromatographic method with ultra violet detection for simultaneous analysis of three sartans (Valsartan, Irbesartan and Telmisartan) has been developed for quality control. Method and Results: Isocratic elution on a LiChrospher C18 column (250 × 4 mm, particle size 5 μm) at the temperature 30ºC with a mobile phase consisting of 10mM phosphate buffer: acetonitrile (65:35 v/v) at a flow rate 1.0 ml/min has been done. The column eluent was monitored with a UV d Drug analysis, Sartans, HPLC, Quality control, Hypertension, Heart failure https://www.ijper.org/article/51/2/260-269 2026-04-13T05:55:23.103709+00:00 Synthesis and Evaluation of Anticancer Activity of 1, 3, 4-Oxadiazole Derivatives against Ehrlich Ascites Carcinoma Bearing Mice and Their Correlation with Histopathology of Liver 2017-03-13 10.5530/ijper.51.2.31 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2-260.pdf A series of 2, 5-disubstituted 1, 3, 4-Oxadiazole derivatives (4A-4G) have been synthesized with the help of different aromatic benzaldehyde and final compounds were characterized by FT-IR, 1H NMR and Mass spectroscopy. The anticancer study was investigated against Ehrlich Ascites Carcinoma (EAC) bearing albino mice. The synthesized (4A-4G) compounds were administered intraperitoneally at dose of 20-25 mg/kg; body weight per day for 7 days after 24 hour of tumor inoculation in mice. The standard Synthesis, 1, 3, 4 oxadiazole, EAC cell, Anticancer activity, FT-IR, NMR https://www.ijper.org/article/51/2/312-320 2026-04-13T05:55:23.103709+00:00 Nephroprotective Hepatoprotective Potential and Antioxidant Role of Carob Pods (Cerotonia siliqua L.) against Carbon Tetrachloride-induced Toxicity in Rats 2017-03-13 10.5530/ijper.51.2.37 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2-312.pdf Objective: The aims of current study are the evaluation of the protective effect and antioxidant role of carob pods against carbon tetrachloride (CCl4)-induced oxidative stress, hepatotoxicity and nephropathy. Material and Methods: The present experiment was designed as I (control), II (0.5 ml/kg CCl4), III (%10 CP), IV (CCl4 0.5 ml/kg+%10 CP) groups. While rats in group I and III were fed with a diet without CCl4, II, and IV groups received twice 0.5 ml/kg/week, where IV group additionally rece Carbon tetrachloride, Carob pods, Protective potential, Antioxidant role https://www.ijper.org/article/51/2/288-294 2026-04-17T08:37:22.057998+00:00 D-Tagatose production by Lactococcus lactis NZ9000 Cells Harboring Lactobacillus plantarum L-arabinose Isomerase 2017-03-13 10.5530/ijper.51.2.34 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2-288.pdf D-tagatose is a functional sweetener present in medicine, food, and dairy products and with broad market prospects, and L-arabinose isomerase gene (araA) can mediate the bioconversion of D-galactose into D-tagatose. In this study, a Lactococcus lactis NZ9000 strain harboring exogenous L-arabinose isomerase was constructed to produce D-tagatose. Lactobacillus plantarum CGMCC 8198 exhibits L-arabinose isomerase activity and its genome has been sequenced. The araA gene of Lactobacillus plantarum CG D-tagatose, L-arabinose isomerase, Lactococcus lactis NZ9000, Lactobacillus, plantarum, Galactose https://www.ijper.org/article/51/2/186-191 2026-04-13T05:55:23.103709+00:00 Improvement on Education of Animal Pharmacy Profession to Adapt the Transformation of Animal Pharmaceutical Industry in China 2017-03-13 10.5530/ijper.51.2.24 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2-186.pdf Aim(s): To introduce the structural adjustment of the animal pharmaceutical industry in China and our improvement on animal pharmacy profession education. Study Design: Investigated the change of this industry, and reported our improvement on the education of this profession. Methods: The development on intensive animal production, nonpollution foods, and marketing mode of animal drugs of animal pharmaceutical industry, and the standardized management system, merger, product development capabili Animal Pharmacy Profession, Education, Animal Pharmaceutical Industry, Structural Adjustment, Personnel Training, Innovation https://www.ijper.org/article/51/2/239-248 2026-04-13T05:55:23.103709+00:00 Bioadhesive Garlic and Ketoconazole Vaginal Tablets for Treatment of Candidiasis 2017-03-13 10.5530/ijper.51.2.29 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2-239.pdf Objective: The study represents design and development of a combination type of bioadhesive vaginal tablets of garlic and ketoconazole by direct compression for enhanced antifungal effect. Material and methods: In these, work ketoconazole tablets, garlic tablets, and garlic and ketoconazole combination tablets were prepared using 32 factorial design. HPMC K15M, chitosan, and microcrystalline cellulose were employed as bioadhesive polymers whereas, sodium bicarbonate and citric acid were incorpor Ketoconazole, Garlic, Bioadhesion, Vaginal candidiasis, Molecular docking https://www.ijper.org/article/51/2/302-311 2026-04-17T08:44:58.156063+00:00 Computational Approach for Locating Effective Cyanobacterial Compounds against Mycobacterium Tuberculosis 2017-03-13 10.5530/ijper.51.2.36 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2-302.pdf Introduction: Mycobacterium tuberculosis has been a grievous pathogen causing staggering infections worldwide; especially its recently drug resistant strains are intractable. The MurA ligase of cell-wall peptidoglycan pathway is the suitable target often used for drug development. Methods: A homology model of MurA enzyme of M. tuberculosis was generated and validated by a Ramachandran plot for use in molecular docking studies with 13 cyano-compounds, along with 4 first-line anti-tuberculosis dru Tuberculosis, MurA enzyme, Cyano-compounds, Antimycobacterial inhibitors, Computational toxicity study, Molecular docking https://www.ijper.org/article/51/2/337-342 2026-04-13T05:55:23.103709+00:00 Validation of Capsaicin in Indian Capsicum Species Through RP-HPLC 2017-03-13 10.5530/ijper.51.2.40 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2-337.pdf Capsaicin is a pungent capsacinoid which differs in capsicum fruit within the species and the cultivars due to its topographical diversity. Here, a comparative estimation of capsaicin in seven varieties of capsicum has been performed by RP-HPLC method. The method was carried out in reverse phase C18 column using acetonitrile and water (1% acetic acid) as mobile phase (65:35 v/v), at the flow rate of 1ml/min. The λmax was detected at 230 nm. The calibration curves were linear in the concentration Ayurveda, Capsaicin, RP-HPLC, Method validation, Capsicum https://www.ijper.org/article/51/2/216-225 2026-04-13T05:55:23.103709+00:00 Examination of the Community Pharmacists’ Intention to Pharmacist Partnership Using the Theory of Planned Behavior: A Structural Equation Model 2017-03-13 10.5530/ijper.51.2.27 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2-216.pdf Background: The ownership types of pharmacies are important because it plays a significant role at the services provided by pharmacists. The competitive structure of community pharmacy sector might prompt pharmacists to pay attention for business issues more than health issues. Similar to all businesses, community pharmacists must protect their profitability to continue their profession functions. In this context, partnerships are thought as a solution for taking market advantage in community ph Community Pharmacist, Pharmacist Partnership, Theory of Planned Behavior, Structural Equation Model https://www.ijper.org/article/51/2/249-259 2026-04-13T05:55:23.103709+00:00 Multi Criteria Decision Making to Select the Suitable Method for the Preparation of Nanocrystals Using an Analytic Hierarchy Process 2017-03-13 10.5530/ijper.51.2.30 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2-249.pdf Purpose: This paper presents a systematic approach for selecting the right method for the preparation of nanocrystals. Aim: The aim of this paper is to provide an analytical tool to select the most appropriate method for the preparation of nanocrystals. Method: The tool that can be useful in determining the most appropriate method is the Analytic Hierarchy Process (AHP). One of the main advantages of this method is the relative ease with which it handles multiple criteria. In addition to this, A Sonoprecipitation, Nanocrystals, Bioavailability enhancement, MCDM, Analytic Hierarchy Process https://www.ijper.org/article/51/2/349-354 2026-04-17T08:51:55.128855+00:00 The Effect of Soy Flour Intake on Systemic Blood Pressure and Glycemic Control in Post-Menopausal Women with Pre-diabetes and Prehypertension 2017-03-13 10.5530/ijper.51.2.42 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2-349.pdf Metabolic syndrome has a high prevalence & fast growing trend of cardiovascular risk factor in post-menopausal women and the prehypertension and pre-diabetes are the predictors of heart disease. In the treatment of metabolic syndrome, dietary management is one of the therapeutic approaches for the control of metabolic risk factors. In few studies the use of the soy has shown the effective results in controlling the systemic blood pressure & glycemic changes in post-menopausal women. However, the Metabolic syndrome, Post- menopausal women, Glycemic control, Systemic, blood pressure, HOMA-IR-Homeostatic model assessment-Insulin resistance https://www.ijper.org/article/51/2/177-185 2026-04-13T05:55:23.103709+00:00 A Supply of Information towards Academic Stress in Students Pursuing Pharmacy Programme in India – An Exploratory Study 2017-03-13 10.5530/ijper.51.2.23 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2-177.pdf Challenging stimulus can lead to positive outcomes such as motivation and improved task performance while threatening ones or distress can result in anxiety, depression and stress. The current prospective observational exploratory study was designed to assess the stressors causing academic stress in pharmacy students of India. In the study a standard stressors scale was designed with 35 questionnaires as open – ended questions to assess both the positive and negative responses of the student par Academics, Exploratoty study, Pharmacy students, Standard questionnaire, Stress https://www.ijper.org/article/51/2/280-287 2026-04-13T05:55:23.103709+00:00 In vivo Pharmacological Effectiveness of Heat-treated Cucumber (Cucumis sativus L.) Juice against CCI4- induced Detoxification in a Rat Model 2017-03-13 10.5530/ijper.51.2.33 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-2-280.pdf Background: Detoxification of heavy metals such as carbon tetrachloride (CCl4) poisoning has become a major focus of researchers. Objectives: In this study, heat-treated cucumber juice was assessed for its pharmacological effect on protection of carbon tetrachloride (CCl4)-induced acute liver and kidney damages. Methods: Initially, during detoxification of CCl4, the rats of all groups except the control group (without treatment) were injected with a single intraperitoneal dose of 2.5 mL CCl4/kg Cucumis sativus, Cucumber juice, CCl4 detoxification, AST, ALT, BUN https://www.ijper.org/article/51/1/20-24 2026-04-17T04:19:15.845593+00:00 Diversity of Pharmacy Faculty Members between UK and US 2017-01-12 10.5530/ijper.51.1.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-1-20.pdf Objective: The aim of the research was to characterize the diversity of current pharmacy faculty members in the US and UK. Methods: An online self-completion survey was designed and sent to the faculty members from the top 40 accredited pharmacy institutions in USA and top 20 in the UK. Data were analyzed to identify differences between pharmacy faculty members in both regions. Results: The response rate was 9.4% (411/4355). In both UK and US, more female faculty members stand at junior academic Diversity, Pharmacy faculty, Comparison, US, UK https://www.ijper.org/article/51/1/156-161 2026-04-13T05:55:23.895223+00:00 Utilization Pattern of Non-steroidal Anti-inflammatory Drugs at a Primary Health Care in Malaysia 2017-01-12 10.5530/ijper.51.1.21 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-1-156.pdf Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) are among medications most commonly prescribed and used world wide mainly in the developed countries. Variation in terms of drug utilization pattern and adverse events may exist in different population and healthcare centres. The objective of the study was to determine consumption pattern of NSAIDs at the Klang health district primary healthcare clinics in Malaysia. Methods: A retrospective cohort study of medical records of patients p NSAIDs, Malaysia, Utilization Pattern, Defined Daily Dosing https://www.ijper.org/article/51/1/102-109 2026-04-13T05:55:23.895223+00:00 Synthesis and Spectroscopic Characterization of Metal Complexes of Rosuvastatin 2017-01-12 10.5530/ijper.51.1.14 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-1-102.pdf Context: Rosuvastatin is a cholesterol lowering drug. It belongs to class statin. It is prescribed to the patients of coronary artery disease; atherosclerosis; thrombosis; increased low-density-lipoprotein; lipid and triglyceride. Aims:It is a newer drug in market and studies over the pharmacodynamics and pharmacokinetics are in progress. Statin therapy is a long term treatment for which its behavior in the presence of other agents is necessary. For this purpose present study is based on the int Rosuvastatin, Statin, IR, NMR, Titration, Metal complex https://www.ijper.org/article/51/1/25-33 2026-04-17T04:20:03.037284+00:00 Identification of Potential Inhibitors against the Human Influenza A Virus Targeting the CPSF30 and RNA Binding Domains of the NS1 Protein: An E-Pharmacophore approach. 2017-01-12 10.5530/ijper.51.1.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-1-25.pdf Background: Common occurrences of influenza virus strains resistant to known neuraminidase and matrix protein inhibitors like oseltamivir and amantadine respectively necessitate the development of newer antivirals. The virus’ non-structural protein (NS1) through its effector domain (ED) and RNA binding domain (RBD) plays significant roles in overcoming the host antiviral response and regulating the virus replication cycle respectively. Aim: This work attempts to identify potential NS1 based inhi Influenza, Non structural (NS1) protein, Molecular docking, E-pharmacophore, mapping, Virtual screening https://www.ijper.org/article/51/1/51-58 2026-04-13T05:55:23.895223+00:00 Morus rubra Extract Induces G1 Cell Cycle Arrest and Apoptosis in Human Lung and Prostate Cancer Cells 2017-01-12 10.5530/ijper.51.1.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-1-51.pdf Objective: Cancer is one of the most deadly types of disease and evasion from apoptosis and unstoppable cell proliferation are accepted as its distinctive features. Many studies have evaluated the cytotoxic effect of different Morus species but, there is no study about cytotoxic effect of Morus rubra. In this study we aimed to evaluate phenolic composition, antioxidant properties and cytotoxic effect of acidified dimethyl sulfoxide extract of M. rubra (AMRE). Method: Antioxidant properties, phen Apoptosis, Cell Cycle, Cytotoxicity, Lung Neoplasms, Morus rubra, Prostate, Neoplasms https://www.ijper.org/article/51/1/34-42 2026-04-13T05:55:23.895223+00:00 DUSR (Distributed Ultrafast Shape Recognition): a Hadoop Based Tool to Identify Similar Shaped Ligand Molecules 2017-01-12 10.5530/ijper.51.1.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-1-34.pdf Background: Identifying potential drug candidates through Ligand-based virtual screening is often associated with processing of huge amount of data and hence is a computational intensive task. Ultrafast Shape Recognition (USR) algorithm has been reported as a faster alternative for molecular shape comparison which maps the chemical structure of query ligand into its shape moment vector to find novel chemical scaffolds in chemical compound libraries. The USR algorithm however was devoid of the ab DUSR (Distributed Ultrafast Shape Recognition), High throughput Screening, Hadoop, MapReduce, Virtual Screening https://www.ijper.org/article/51/1/136-143 2026-04-13T05:55:23.895223+00:00 Prevalence and Risk Factors of Anxiety among Female Governmental Secondary Schools Students in Al-madinah, Saudi Arabia 2017-01-12 10.5530/ijper.51.1.18 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-1-136.pdf Aim: The study aimed to measure the prevalence and risk factors of Anxiety among Female Governmental Secondary schools students, in Al-Madinah, Saudi Arabia. Methods: Cross sectional study was conducted in Al-Madinah city in 2014. Only Female secondary school students were included for study. Multistage sampling technique was used for student’s inclusion. The researcher used a self-administered questionnaire containing socio-demographic data and anxiety questionnaire developed by AL-Taif Mental Anxiety, Adolescents, Psychosocial disability, Secondary school students, School examinations, Stress disorder https://www.ijper.org/article/51/1/128-135 2026-04-17T04:32:45.95592+00:00 Design of Experiments for Coating Process of Valsartan and Pravastatin Fixed-dose Combination Tablet 2017-01-12 10.5530/ijper.51.1.17 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-1-128.pdf Aim of work: The purpose of this study was to prepare the ranges of critical process parameters (CPP) (spray rate, pan speed, and inlet temperature) in the coating process of valsartan and pravastatin fixed-dose combination (FDC) tablets using design of experiment (DoE). A central composite face-centered DoE with three center points was employed in this study. Method: Valsartan and pravastatin FDC tablets were manufactured by wet granulation, drying, sieving, blending, tableting and coating. For Valsartan, Pravastatin, Quality by design, Design of experiment, Coating https://www.ijper.org/article/51/1/9-13 2026-04-13T05:55:23.895223+00:00 Using Vincent van Gogh’s Illnesses to Revise Medicinal Chemistry 2017-01-12 10.5530/ijper.51.1.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-1-9.pdf Objective: Review sessions provide an opportunity for the students to revise materials they have learned previously. A case study has been designed using the story of Vincent van Gogh, a legendary painter with various illnesses. With this case study, almost all kinds of central nervous system drugs, including antidepressants, sedative– hypnotics, anti-epileptics, analgesics and antipsychotic drugs were reviewed, and several basic concepts of medicinal chemistry were revised, from pharmacokinetic Second-Year Undergraduate, Chemical Education Research, Analogies/, Transfer, Medicinal Chemistry https://www.ijper.org/article/51/1/144-149 2026-04-13T05:55:23.895223+00:00 Antibiotic De-escalation Therapy in Neurosurgical Patients with Ventilator-Associated Pneumonia in Intensive Care Unit: A Retrospective Observational Study 2017-01-12 10.5530/ijper.51.1.19 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-1-144.pdf Context: Antibiotic de-escalation practice is gaining interest in the intensive care units (ICU). However, there is limited evidence to support this approach in neurosurgical patients with Ventilator-Associated Pneumonia (VAP) in ICU. Aims: This study examined the practice of antibiotic de-escalation in neurosurgical patients with VAP in ICU and its impact on mortality. Settings and Design: Retrospective cross-sectional study conducted in an ICU of a public hospital in Malaysia. Methods and Mate Antibiotic de-escalation, Ventilator-associated pneumonia, Neurosurgical, Critical care, Critically-ill patients https://www.ijper.org/article/51/1/110-115 2026-04-13T05:55:23.895223+00:00 Molecular Docking studies and in-silico ADMET Screening of Some novel Oxazine substituted 9-Anilinoacridines as Topoisomerase II Inhibitors 2017-01-12 10.5530/ijper.51.1.15 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-1-110.pdf Introduction: In general, 9-aminoacridine derivatives are inhibiting DNA topoisomerase II (topoII) because of their strong activity due to the ability of acridine nucleus to intercalate into DNA base pair. To get insight of the intermolecular interactions, the molecular docking studies are performed at active site of topoisomerase II. Aim: In this study, an attempt is made for identification of potential ligands from oxazine substituted 9-anilino acridines targeted against topoisomerase-II (1ZXM Topoisomerase-II, Acridine, Oxazine, Antitumour, Docking studies, Insilico, ADMET screening https://www.ijper.org/article/51/1/59-69 2026-04-13T05:55:23.895223+00:00 Protective Effect of Heat-Treated Cucumber (Cucumis sativus L.) Juice Against Lead-Induced Detoxification in Rat Model 2017-01-12 10.5530/ijper.51.1.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-1-59.pdf Background: In recent years, the development of efficient green chemistry approaches for detoxification of heavy metal such as lead (Pb) poisoning has become a major focus of researchers. Objectives: This study was aimed to evaluate the effectiveness of heattreated cucumber juice on the protection of Pb-induced acute liver and kidney damages. Methods: Initially, during detoxification of lead, lead acetate (200 ppm dissolved in distilled water) was given to rats in drinking water for 5 weeks. Cuc Cucumis sativus, Cucumber juice, Lead-detoxification, RBC, Histology, Histomorphometry https://www.ijper.org/article/51/1/1-8 2026-04-17T04:14:17.634295+00:00 Factor VIIa and Factor IXa Inhibitors as Anticoagulants: A Review 2017-01-12 10.5530/ijper.51.1.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-1-1.pdf Introduction: Anticoagulants are used as preventive agents in deep vein thrombosis to prevent blood clots, venous and arterial thromboembolism, but the current therapy of anticoagulants have several limitations like patient variable response, enhanced chances of bleeding and heparin-induced thrombocytopenia (HIT). Factor VIIa and factor IXa play an important role in coagulation cascade and hence are promising targets for drug development. FIXa has been targeted by various means including oral in Anticoagulants, FVIIa/TF, FIXa, Inhibitors, Serine protease https://www.ijper.org/article/51/1/92-101 2026-04-13T05:55:23.895223+00:00 Characterization of Peripheral Neuropathy in Rat Model of Type 2 Diabetes 2017-01-12 10.5530/ijper.51.1.13 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-1-92.pdf Diabetic neuropathy, a microvascular complication associated with diabetes, is one of the most common forms of neuropathy. Current rodent models of type 2 diabetes are mostly transgenic which fail to mimic human type 2 diabetes and its secondary complications, including peripheral neuropathy. Our aim is to develop a non-transgenic animal model of type 2 diabetic neuropathy which closely mimics the human disease. Methods: High-fat diet (HFD; normal pellet diet + lard) and a dual dose of streptozo Animal model, Diabetes, Neuropathy, Glibenclamide, Rat https://www.ijper.org/article/51/1/43-50 2026-04-17T04:22:33.117619+00:00 Optimizing the Amino Acid Sequences of Peptides and Improving Their Specificity of Binding to SH3 Domains of Target Proteins 2017-01-12 10.5530/ijper.50.1.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-1-43.pdf Introduction: It is always a crucial challenge in biotechnology to avoid promiscuous binding between an anticancer peptide and multiple SH3 domains, thus reducing potential toxic effects. In spite of a great deal of experimental efforts, the association between amino acid sequence and binding specificity of peptide remained largely unknown. Aim: The purpose of this study was to optimize the amino acid sequence of peptide ligands and render high specificity towards designated therapeutic targets. SH3 domain, c-Src, promiscuity, specificity, peptide rational design https://www.ijper.org/article/51/1/116-127 2026-04-13T05:55:23.895223+00:00 Development and Evaluation of Diclofenac sodium Controlled Release Dosage Forms Using Natural, Hydrophilic and Hydrophobic Polymers and its Comparative Studies 2017-01-12 10.5530/ijper.51.1.16 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-1-116.pdf The aim of the present study is to develop the controlled release dosage form of diclofenac using hydrophilic polymers (xanthan gum from natural origin, hydroxy propyl methyl cellulose K 100M from semisynthetic origin) and hydrophobic polymer (compritol 888 ATO from synthetic origin). Diclofenac sodium matrix tablets were prepared by xanthan gum and hydroxy propyl methyl cellulose by wet granulation method. Hot melt granulation method was used for compritol as it was insoluble polymer. Fourier t Diclofenac sodium, Hydroxy propyl methyl cellulose K 100M, Xanthan gum, controlled release dosage forms, Compritol 888 ATO https://www.ijper.org/article/51/1/150-155 2026-04-13T05:55:23.895223+00:00 Vildagliptin and Insulin Combinatorial Therapy Drug Safety Monitoring in Diabetic Rats 2017-01-12 10.5530/ijper.51.1.20 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-1-150.pdf Background: Type 2 Diabetes Mellitus is a long term metabolic disorder that is characterized by high blood sugar, insulin resistance, and lack of insulin. Based on the understanding of the pathogenesis of T2DM, several distinct pharmacological therapies have been developed but many of them are producing significant adverse drug reactions. Objectives: The present study helps to understand the progression of hepatic degeneration in diabetes mellitus upon treatment with vildalgliptin and insulin. T Vildagliptin, Insulin, Hepatic tissues, Incretins, Adverse effects https://www.ijper.org/article/51/1/83-91 2026-04-13T05:55:23.895223+00:00 Role of Brain Angiotensin (1-7) In Chronic Hyperglycaemia Induced Nephropathy in Wistar Rats 2017-01-12 10.5530/ijper.51.1.12 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-1-83.pdf Objective: Ang (1-7) recognised as a biologically active component of renin angiotensin system (RAS). It has been documented that peripheral activity of Ang (1-7) gets reduced during diabetic nephropathy (DN) which is one of the most common cause of end stage renal disease. Peripheral activity of RAS is regulated by brain RAS. The purpose of present study is to investigate the role of brain angiotensin (1-7) in chronic hyperglycemia induced nephropathy in wistar rats. Material and methods: Diabe Ang (1-7), diabetic nephropathy, alloxan, valsartan, brain renin angiotensin, system https://www.ijper.org/article/51/1/77-82 2026-04-17T04:26:27.164625+00:00 Effect of Pravastatin on Levels of Filtration Slit Diaphragm Protein and Oxidative Stress in Doxorubicin- Induced Nephrotoxicity 2017-01-12 10.5530/ijper.51.1.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-1-77.pdf Introduction: Nephrotoxicity is one of the complications the use of doxorubicin (DXR) which may be caused by the formation of free radicals. The aim of this study was to investigate the effects of pravastatin (PS) on doxorubicin-induced nephrotoxocity. Methods: The rats were divided into control, doxorubicin (15 mg/kg, i.p.), PS (20 mg/kg orally, 5 days prior to DXR injection) + DXR and DXR + PS (5 days after DXR injection) groups. At the end of the 20th day, kidneys were removed for evaluation. Pravastatin, Doxorubicin, Nephrotoxicity, Oxidative stress, Podocin https://www.ijper.org/article/51/1/70-76 2026-04-17T04:25:35.629673+00:00 Pharmacognostic Evaluation of DPSUU III IN Breast Tumor Growth By G0/G1 Cell Cycle Arrest 2017-01-12 10.5530/ijper.51.1.10 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-1-70.pdf Objective: Plant-inferred bioactive particles have been utilized to turn away or treat tumor for a considerable length of time. As of late plant blends were found to have significantly more grounded exercises than utilizing plant alone. In this study, we evaluated the anticancer impacts of DPSUU III which contains a mix of plant concentrates of Beta vulgaris, Syzygium cumini, Limonia acidissima. Material and Methods: After extraction from these plants, DPSUU III was granulated and powder was ext Breast cancer, DPSUU III, G0/G1, anti-cancer, cyclin D1 https://www.ijper.org/article/51/1/14-19 2026-04-17T04:18:12.999206+00:00 Effect of integrating research skills with basic sciences in an interdisciplinary integrated endocrine module on students’ satisfaction and performance 2017-01-12 10.5530/ijper.51.1.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-51-1-14.pdf Background: A system-based integrated curriculum has been implemented at Faculty of Medicine, King Abdulaziz University since the academic year 2006/2007. There were many calls to increase the integration level and to integrate the scientific research skills into the medical curriculum. Objectives: This study aimed to document the steps taken to establish a higher level of integration of basic sciences along with the scientific research skills and to assess the effect of such changes on student System- based, Module, Integration, Research, Satisfaction, Performance https://www.ijper.org/influence-of-trainee-characteristics-on-acquired-pharmacology-knowledge-of-denta 2026-04-17T06:03:18.70586+00:00 Influence of Trainee Characteristics on Acquired Pharmacology Knowledge of Dental Professionals: A Pilot Study 2016-08-26 10.5530/ijper.50.3.38 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3s-280.pdf Background: Organizations spend an extensive amount of time and money on training in order to promote employees’ learning, development, and job-related competencies. This study examined the influence of trainee characteristics of the dental practitioners attending the continuing medical education (CME) on“dental pharmacology and patient safety” and their effect on acquired knowledge. Methods: The trainee characteristics of the dental practitioners were conceptualized into four dimensions: m Acquired Knowledge, Expectation, Organizational Commitment, Motivation, Training https://www.ijper.org/development-and-evaluation-of-azelaic-acid-based-ethosomes-for-topical-delivery 2026-04-13T05:55:25.876493+00:00 Development and Evaluation of Azelaic Acid Based Ethosomes for Topical Delivery for the Treatment of Acne 2016-08-26 10.5530/ijper.50.3.34 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3s-232.pdf Purpose: To design, develop and evaluate an Azelaic acid encapsulated Ethosomal formulation for acne. Methods: Encapsulated ethosomes were prepared by three methods viz. hot method, cold method and thin film hydration method. Central Composite Design was employed for optimisation of ethosomal formulations. Concentrations of phospholipid, cholesterol and ethanol were selected as independent variables and their effect on the dependent variables (Entrapment Efficiency and Drug Diffused) was s Ethosomes, Azelaic acid, Composite, Vesicles, Propionibacterium acne, Topical https://www.ijper.org/assessment-of-pharmacognostic-phytochemical-and-physicochemical-standards-of-ara 2026-04-17T05:57:37.228397+00:00 Assessment of Pharmacognostic, Phytochemical and Physicochemical Standards of Aralia racemosa (L.) root 2016-08-26 10.5530/ijper.50.3.33 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3s-225.pdf Context: Ethnomedicinally, the root of Aralia racemosa L. (Araliaceae) has long been used in various ailments in traditional system; most importantly it is used against rheumatism, whooping cough, skin diseases, pleurisy, diaphoretic, diuretic, asthma, diarrhoea, syphilis, inflammation and hay fever. The main problem experienced in standardization of herbal drugs is lack of proper identification of plant source. So there is need to establish quality control parameters by using pharmacognost Pharmacognostic, Microscopical, Lignified sclerides, Aralia racemosa. L, physicochemical and Lignified spiral vessels https://www.ijper.org/ameliorative-effect-of-quercetin-on-methotrexate-induced-toxicity-in-sprague-daw 2026-04-17T05:51:12.389122+00:00 Ameliorative Effect of Quercetin on Methotrexate Induced Toxicity in Sprague-Dawley Rats: A Histopathological Study 2016-08-26 10.5530/ijper.50.3.30 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3s-200.pdf Objective: To study the effect of quercetin on methotrexate induced toxicity and to observe the histopathological changes. Materials and Methods: Thirty male rats were divided into 5 different groups with each group consisting of six rats. The Group I was a control and they were treated with 10 ml/kg of carboxymethyl cellulose. The Group II, III, IV and V animals were treated with methotrexate 0.125 mg/kg; methotrexate 0.25 mg/kg; methotrexate (0.125 mg/kg) + quercetin (500 mg/kg); and meth Antioxidants, Cytotoxicity, Histopathology, Methotrexate, Quercetin https://www.ijper.org/a-new-self-microemulsifying-mouth-dissolving-film 2026-04-17T05:50:18.346331+00:00 A New Self Microemulsifying Mouth Dissolving Film 2016-08-26 10.5530/ijper.50.3.29 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3s-191.pdf A self micro-emulsifying mouth dissolving film (SMMDF) is a dosage form which is based on mouth dissolving film integrated with self micro emulsifying components. Stability of self-micro emulsifying drug delivery system is one of major problem of lipid based drug delivery system. This can be minimized by converting liquid self micro emulsifying drug delivery system into solid SMMDF. This drug delivery system enjoys both advantages of self micro emulsifying drug delivery system (SMEDDS) alon Bioavailability, Lipid based drug delivery system, Mouth dissolving film, Self micro emulsifying drug delivery system and Self micro-emulsifying mouth dissolving film. https://www.ijper.org/understanding-unconventional-routes-to-impurities-from-drugs-in-hydrolytic-condi 2026-04-17T05:47:33.191339+00:00 Understanding unconventional routes to impurities from drugs in hydrolytic conditions 2016-08-26 10.5530/ijper.50.3.28 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3s-161.pdf Introduction: Hydrolytic degradation is the most common cause of formation of impurities or degradation products in drugs during different stages of drug product development and/or shelf life of the drug/product. Degradation products formed by hydrolysis of ester, amide, urethane, sulfonamide, sulfonate and ether linkages, and of nitrile, hydroxyl and amino groups in drugs can be conveniently predicted and identified. Many drugs are known to degrade to such expected conventional hydrolytic Forced degradation, Impurities, Hydrolysis, Conventional, Unconventional, Mechanisms https://www.ijper.org/influence-of-metals-in-soil-on-the-comparative-phyto-chemical-characterization-a 2026-04-17T06:02:32.245571+00:00 Influence of Metals In Soil on The Comparative Phyto chemical Characterization and Antioxidant Study of Indian Golden Shower (Cassia Fistula) 2016-08-26 10.5530/ijper.50.3.37 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3s-266.pdf Objective: This paper highlighted the effect of selected soil containing metals, viz. Cd, Cr, Cu, Fe, Ni, Pb and Zn on the biochemical compositions and antioxidant activity in leaf of 20 years old two Cassia fistula L. (CF) cultivars. The leaf samples were collected from CF grown on road sides from the states of Maharashtra and Karnataka in India. Methods: Antioxidant activity and total phenol contents from methanolic and aqueous leaf extract were evaluated by assays like oxygen radical Antioxidant, CF leaf, Metal risk, Soil, Total phenols https://www.ijper.org/pharmaceutical-pellets-a-versatile-carrier-for-oral-controlled-delivery-of-drugs 2026-04-13T05:55:25.876493+00:00 Pharmaceutical Pellets: A Versatile Carrier for Oral Controlled Delivery of Drugs 2016-08-26 10.5530/ijper.50.3.27 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3s-146.pdf In pharmaceutical industries, pellets are multiparticulate dosage form which was formed by the agglomeration of fine powdered excipient and drugs together that leads to the formation of small free flowing spherical or semi spherical particles. This technique is called as pelletization process. Pellets are typically varied between 500-1500 µm in size for pharmaceutical applications. It is of great interest over other similar techniques due to its uniformity of dose, less susceptibility of do Cryopelletization, Extrusion, Fluidized bed Processor, Layering, Spheronization https://www.ijper.org/the-comparison-and-analysis-of-two-extraction-methods-for-polysaccharides-in-psi 2026-04-17T05:56:33.70247+00:00 The Comparison and Analysis of Two Extraction Methods for Polysaccharides in Psidium guajava L. Fruits 2016-08-26 10.5530/ijper.50.3.32 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3s-218.pdf Introduction: Fruit polysaccharides, essential health factors in foods, are widely present in edible fruits. Several methods for isolation of polysaccharide are available. Microwave Assisted Extraction (MAE) method is extensively used for separation of polysaccharides. Only little information is available about Psidium guajava L. Fruit Polysaccharide (PFP) and its extraction methods. Objective: In this study, two extraction methods of polysaccharides in Psidium guajava L. fruit were compared and Guava, Polysaccharides, Extraction, Optimization, Taguchi orthogonal, Comparison https://www.ijper.org/formulation-and-evaluation-of-controlled-release-gastro-retentive-in-situ-gel-fo 2026-04-17T06:00:58.16409+00:00 Formulation and Evaluation of Controlled Release Gastro-Retentive In situ Gel for Diltiazem Hydrochloride 2016-08-26 10.5530/ijper.50.3.36 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3s-254.pdf In present study is to develop Gastro-Retentive controlled release in situ gel using natural and synthetic polymers. Gastro-retentive controlled release in situ gels were prepared to controlled drug delivery, to improve bioavailability, stability, reducing side effects. For the present work 32 factorial designs was selected. The two independent variables were selected sodium alginate (X1) and ratio of polymers HPMC K4M: Gellum Gum (X2) combined concentration of HPMC K4M and Gellum Gum was kept c Diltiazem HCL, Gastro-retentive In situ Gel, HPMC, Sodium Alginate, Tri-Sodium Citrate https://www.ijper.org/improved-dissolution-and-bioavailability-of-eprosartan-mesylate-formulated-as-so 2026-04-13T05:55:25.876493+00:00 Improved Dissolution and Bioavailability of Eprosartan Mesylate Formulated as Solid Dispersions using Conventional Methods 2016-08-26 10.5530/ijper.50.3.31 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3s-209.pdf Background: Eprosartan mesylate (EM) is a poorly aqueous soluble drug belonging to BCS-class II suffers from low bioavailability (13%). The present study involves an effort for improving dissolution and thus the bioavailability of EM using solid dispersion approach. Methods: Solid dispersion (SD) was prepared by melting, solvent evaporation and kneading method using different ratios of drug and polymers (PEG-4000, Eudragit E-100, PVP K-30, Poloxamer-407, and Eudragit L-100). Phase solubilit Eprosartan mesylate, Solid dispersion, Dissolution, Bioavailability, Characterization https://www.ijper.org/repositioning-of-eugenol-in-treatment-of-gastric-ulcers-through-development-of-f 2026-04-13T05:55:25.876493+00:00 Repositioning of Eugenol in Treatment of Gastric Ulcers Through Development of Floating In situ Gel 2016-08-26 10.5530/ijper.50.3.35 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3s-244.pdf Theoral liquid dosage forms are more prone to low bioavailability because of their quick transit from the stomach. Producing sustained release formulation of an oral liquid dosage formcould be successfully augmented through a strategy of liquid in-situ gelling system. In-situ forming polymeric formulation is in sol form before administration in the body, but once administered undergoes in-situ gelation. The objective of this study was to develop a novel in-situ gel system of eugenol for tre Floating in situ gel, Eugenol, Gellan gum, Sodium alginate, Pharmacodynamics, studies, X-ray https://www.ijper.org/article/50/4/512-516 2026-04-13T05:55:25.055093+00:00 Objective Structured Clinical Examination in Undergraduate Pharmacy Students: Time to Switching to an Alternative Exam for Clerkship Courses 2016-08-24 10.5530/ijper.50.4.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-512.pdf Background: Significant changes in the clinical context of health professional education and impressive body of research on the measurement of clinical competence support the use of the Objective Structured Clinical Exam (OSCE) as the preferred means of performance-based assessment to current teaching and evaluation method. The objective of this paper is to describe how the OSCE method was developed and applied to an undergraduate community pharmacy clerkship course, as a pilot for assessin Educational Assessment, Pharmacy Students, Pharmacy Education, Clinical, Clerkships, Educational Measurements https://www.ijper.org/article/50/4/542-548 2026-04-17T06:13:21.781356+00:00 Present Status of Pharmacy Education and Practice in Angola: Trends and Challenges 2016-08-24 10.5530/ijper.50.4.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-542.pdf Pharmacy education in Angola, the second largest sub-Saharan country after the Demo cratic Republic of Congo, has undergone some changes since the first pharmacy school was established in 2001. Currently, to practice as a pharmacist, one needs a pharmacy degree. This university degree is awarded after 5 years of pharmacy studies offered only at 7 Pharmacy Schools located mainly in the capital city. This article describes the Angolan pharmacy education framework, including criteria for admiss Angola, Curriculum, Pharmacy Education, Pharmacy practice, University https://www.ijper.org/article/50/4/574-582 2026-04-17T06:19:18.536452+00:00 Identification of novel drug candidate against Mycobacterium Tuberculosis InhA protein through Computer aided drug discovery 2016-08-24 10.5530/ijper.50.4.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-574.pdf Tuberculosis is a common and often deadly infectious disease caused by Mycobacteria. WHO estimates that around eight million people are suffering from tuberculosis every year. The Administration of antibiotics fails due to the multi-drug resistant capability of Mycobacterium. Traditional methods require time and huge investment. Therefore, it is essential to provide an alternative strategy to treat tuberculosis disease. The present study conducted molecular docking against InhA protein, whi Active site docking, Hydrogen bonding, Latent infection, Ligand, Pathway, Resistant, Score, Selection, Target https://www.ijper.org/article/50/4/517-529 2026-04-13T05:55:25.055093+00:00 Evaluation of the E-Learning Program Impact over Organizations in the Romanian Pharmaceutical Industry 2016-08-24 10.5530/ijper.50.4.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-517.pdf This research aims to measure the impact of some initiatives within the human resources over an organization, market leader in the pharmaceutical field, the measurement of efficiency concerning the business education programs by human resources e-learning, respectively. Under the circumstances, the research carried-out allow for the application into practice of the theoretical frame of the ROI methodology (Return On Investment) of evaluating the education programs in the human resources bus E-learning, Business Education, ROI methodology, Romanian Pharmaceutical, Industry, Evaluation of E-learning Program https://www.ijper.org/article/50/4/638-648 2026-04-13T05:55:25.055093+00:00 Anti-inflammatory screening of ethanolic leaf extract of Vernonia arborea Buch. –Ham.in formalin induced albino wistar rats 2016-08-24 10.5530/ijper.50.4.16 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-638.pdf Context: The therapeutic potential of the genus Vernonia has been well documented over the years. However the pharmacological potential of the plant Vernonia arborea (Asteraceae) has been relatively less explored. Objective: To investigate the anti inflammatory effect of the ethanol leaf extract of V. arborea against formalin induced inflammation in rats. Materials and methods: Formalin induced inflammation method was used to induce inflammation in rats.0.1 ml/kg body weight (b.w.) of formal Vernonia arborea, formalin induced inflammation, indomethacin https://www.ijper.org/article/50/4/649-656 2026-04-17T06:29:30.548787+00:00 Protective Effects of -3 fatty acids and/ or Nano- selenium on Cisplatin and Ionizing radiation induced liver toxicity in rats 2016-08-24 10.5530/ijper.50.4.17 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-649.pdf Cisplatin (CP) and/ or radiation exposures cause oxidative stress, which induced liver toxicity. The present study was undertaken to explore if fish oil (FO) and /or selenium nano particles (SeNPs) can minimize CP-induced hepatotoxicity and other side effects. Rats were either treated with SeNPs (0.5 mg/kg) and /or FO (2 mg/Kg) for 12 days before treatment with CP (10 mg/Kg) and/ or exposure to γ-rays (0.7Gy).The results of the present study revealed that rats treated with CP and /or γ- ra Ionizing radiation, Cisplatin, Omega 3, Selenium nano particles, Nrf2, NF-κB https://www.ijper.org/article/50/4/605-611 2026-04-17T06:26:05.404706+00:00 Rosuvastatin Loaded Nanostructured Lipid Carrier: For Enhancement of Oral Bioavailability 2016-08-24 10.5530/ijper.50.4.13 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-605.pdf Rosuvastatin is a lipid lowering agent, which has low solubility and low bioavailability of 20% with oral administration. Therefore the present study was undertaken to improve solubility and bioavailability of Rosuvastatin by formulating it into Nano structured lipid carriers (NLCs) by using stearic acid and Compritol ATO 888 as solid-lipid, Oleic acid as liquid-lipid and Poloxamer 188 as a surfactant. Rosuvastatin loaded NLCs were prepared by high shear homogenisation followed by Ultra son Rosuvastatin, Nano structured, Stearic acid, Compritol, Homogeniser https://www.ijper.org/article/50/4/563-573 2026-04-17T06:17:22.066622+00:00 A Novel QbD Based SPE-HPLC Bio-analytical Method for Edaravone in Rat Plasma, A Pharmacokinetic Study 2016-08-24 10.5530/ijper.50.4.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-563.pdf A simple, sensitive and feasible Quality by design based RP-HPLC bioanalytical method was developed and validated for Edaravone. Plackett burman design and 3¥3 full factorial designs were utilized for factor screening and optimization respectively, to achieve well resolved asymmetric peaks of both internal standard and drug with good theoretical plates. The optimized chromatographic peak was obtained with mobile phase composition of 10 mM ammonium acetate buffer (pH 6) and acetonitrile (60:40, v QbD, SPE, Bioanalytical method, Edaravone, Carbamazepine https://www.ijper.org/article/50/4/657-664 2026-04-17T06:30:44.866496+00:00 HPTLC Method Development and Validation of Antidiabetic Marker Compound from Polyherbal Formulation 2016-08-24 10.5530/ijper.50.4.18 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-657.pdf The objective of this research work was to develop a simple, rapid and reliable HPTLC method for standardization of anti-diabetic polyherbal formulation and to carry out validation of Trigonelline in formulation. Development of method was carried out by using Quercetin, Gallic Acid, Curcumin and Trigonelline as bioactive markers reported to have an anti-diabetic activity. Chromatographic analysis was performed using silica gel 60 F254 TLC plate, CAMAG Linomat 5 applicator and solvent system cons Polyherbal formulation, Marker Compounds, HPTLC Method development, Validation https://www.ijper.org/article/50/4/689-694 2026-04-13T05:55:25.055093+00:00 Chromatographic Fingerprint Analysis of Hydro alcoholic extract of Medicinally Important plant Elephantopus scaber l. Using HPTLC Technique 2016-08-24 10.5530/ijper.50.4.21 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-689.pdf Objective: To develop chemical fingerprint profile of secondary metabolites of therapeutically important plant Elephantopus scaber L. using HPTLC technique. Method: Preliminary phytochemical investigation was performed for the detection of secondary metabolites. HPTLC fingerprint profile of hydro-alcoholic extract of E. scaber was developed for alkaloids, flavonoids and saponins. Toluene: Ethyl acetate: Diethyl amine (7:2:1), Ethyl acetate: Formic acid: Glacial acetic acid: Water (10:0.5:0. HPTLC Fingerprinting, E. Scaber, Chromatograms, Biomarker, Rf value https://www.ijper.org/article/50/4/695-702 2026-04-17T06:33:08.020787+00:00 Management of pharmaceutical waste in hospitals in Serbia – challenges and the potential for improvement 2016-08-24 10.5530/ijper.50.4.22 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-695.pdf Background: Left over medication widely used in hospitals for the treatment of various diseases including malignant illnesses, stand to represent a hazardous form of healthcare waste. According to regulations in the Republic of Serbia dating back to 2009, all healthcare facilities are obligated to separate, label and safely put away said leftover medication, i.e. forward it to authorised operators in order to be securely shipped and properly taken care of abroad. Pharmaceutical waste can le Healthcare waste management, factors, pharmaceutical waste, training, hospital https://www.ijper.org/article/50/4/612-619 2026-04-13T05:55:25.055093+00:00 Picogram Level Quantification of Grazoprevir and Elbasvir with Deuterated Internal Standards in Human Plasma Samples by LC–ESI-MS/MS 2016-08-24 10.5530/ijper.50.4.14 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-612.pdf A fixed oral dose combination of grazoprevir and elbasvir is used for the treatment of patients with genotypes 1&4 HCV infections. In this manuscript, authors developed a simple, sensitive and specific liquid chromatography–tandem mass spectrometry (LC–MS/MS) method used for quantification of grazoprevir and elbasvir in human plasma. Agilent TC-C18, 4.6 x 75 mm, 3.5 μm, 80 Å column, and 5 mM ammonium acetate: acetonitrile (20:80 v/v) mobilephase was used for Chromatographic separation. M LC-ESI-MS/MS, Grazoprevir, Elbasvir, Human plasma, Bioanalytical https://www.ijper.org/article/50/4/620-637 2026-04-17T06:27:34.647241+00:00 Evaluation of Antioxidant, Toxicological and wound healing Properties of Hibiscus rosa-sinensis L. (Malvaceae) ethanolic leaves extract on different Experimental animal models 2016-08-24 10.5530/ijper.50.4.15 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-620.pdf Objective: The present research article was conducted to study the toxicity profile, antioxidant potential and wound healing activity of ethanolic leaves extract of Hibiscus rosa-sinensis L. (ELEHR). Materials and Methods: In-vitro antioxidant properties were assessed using DPPH radical scavenging activity, Nitric oxide scavenging activity, and superoxide radical scavenging activity. Acute toxicity was performed to study the general behavioural pattern of mice and sub-acute toxicity studies Antioxidant, Burn injuries, Hibiscus rosa-sinensis, Normal wound healing, Toxicity profile https://www.ijper.org/article/50/4/591-598 2026-04-17T06:21:50.237751+00:00 Synthesis and Antimalarial Activity Evaluation of Some Mannich Bases of Tetraoxane-Phenol Conjugate 2016-08-24 10.5530/ijper.50.4.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-591.pdf A new series of seven Mannich bases of tetraoxane-phenol conjugate as possible antimalarial compounds were synthesized and evaluated in vitro for their antimalarial activity. All the synthesized compounds exhibited good antimalarial activity against the CQ-sensitive strain (RKL-2) of P. falciparum. Compounds with 3-indolyl and phenolic substituent’s showed considerably superior activity than rest of the synthesized tetraoxane derivatives in the series, with IC50 values 8.19 μg/ml and 5.30 μg/ml, Mannich base, Tetraoxane, Endoperoxide, Plasmodium falciparum, Resistant, malaria https://www.ijper.org/article/50/4/583-590 2026-04-13T05:55:25.055093+00:00 Inhibition of hesperidin on epithelial to mesenchymal transition of non-small cell lung cancer cells induced by TGF 2016-08-24 10.5530/ijper.50.4.10 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-583.pdf Transforming growth factor-β1 (TGF-β1) is a known potent inducer causing epithelial to mesenchymal transition(EMT) in some cancers. The present study was to evaluate the effect of hesperidin on EMT of non-small cell lung cancer (NSCLC) in vitro. In this study, A549 cells, a cellular line of non-small cell lung cancer, were used for evaluation of EMT induced by TGF-β1. MTT assay was used to evaluate the effect of hesperidin on cell viability with or without TGF-β1 co-culture. At the same tim Hesperidin, Non-small cell lung cancer, Transforming growth factor-β1, Proliferation, Epithelial to mesenchymal transition https://www.ijper.org/article/50/4/703-707 2026-04-17T06:33:50.476707+00:00 Study of Relative Association, Apparent Molar Compressibility and Free Length of Entacapone API in alcohols at different Frequencies 2016-08-24 10.5530/ijper.50.4.23 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-703.pdf The values of ultrasonic velocity is measured by using ultrasonic interferometer for 0.01M solution of entacapone in methanol, ethanol, 1-propanol and 1-butanol as a solvent at 303.15 K by using frequency 2 MHz, 4 MHz and 6 MHz. This experimental data is used to explore the acoustic properties like intermolecular free length, relative association and apparent molar compressibility. From these thermodynamic and acoustic properties, the molecular interactions like solute-solute and solute-sol Ultrasonic interferometer, Apparent molar compressibility, Intermolecular, free length, Relative association, Molecular interaction https://www.ijper.org/article/50/4/598-604 2026-04-17T06:23:29.075041+00:00 Schiff’s base derivatives of murrayanine demonstrated enhanced anti-oxidant activity than its parent moiety 2016-08-24 10.5530/ijper.50.4.12 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-598.pdf Objective: Free radicals like superoxide anion radical (O2.-), hydroxyl radical (HO.), alkyl radical (R.), alkoxy radical (RO.), peroxy radical (ROO.) and nitric oxide radical (NO.) often leads to oncogenic proliferation, damage deoxyribosyl backbone of DNA, accelerate oxidation of polydesaturated fatty acids, amino acids, and several other co-factors. Several carbazole moieties present in M. koenigii L. like murrayanine, mahanimbine, curryanine, kurryam have been reported to exhibit good anti-o Murrayanine, Carbazole, Schiff’s base, Anti-oxidant, Semi-synthetic https://www.ijper.org/article/50/4/676-688 2026-04-13T05:55:25.055093+00:00 Formulation, Solid State Characterization and Enhancement of Dissolution Rate of Olmesartan Medoxomil by Polyvinyl Alcohol-Polyethylene Glycol Graft Copolymer Based Nanoparticles 2016-08-24 10.5530/ijper.50.4.20 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-676.pdf The objectives of present investigation were to prepare and evaluate nanoparticles of Olmesartan medoxomil (OLM) by a precipitation method using polyvinyl alcohol- polyethylene glycol graft copolymer (Kollicoat IR) and to investigate the effect of stirring speed & time on particle size. Particles were characterized for drug content, FTIR, zeta potential (ZP), particle size distribution (Dynamic light scattering), differential scanning calorimeter (DSC), powder X-ray diffraction (PXRD), scan Drug nano particles, Anti solvent method, Olmesartan medoxomil, Kollicoat IR, Solubility and Dissolution https://www.ijper.org/article/50/4/665-675 2026-04-17T06:31:34.940807+00:00 Hydroxypropyl β-Cyclodextrin (HBC) Multicomponent Complexation and pH independent controlled release delivery system to Improved Dissolution and oral Bioavailability of Ondansetron HCI 2016-08-24 10.5530/ijper.50.4.19 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-665.pdf The objective of this study was to develop pH independent controlled release matrix tablets of Ondansetron HCl by using Multi component Complexation technique, Methocel K100M as release retarding materials and HP β-cyclodextrin was selected as release modulators. Ondansetron is weakly basic drug and their salts shows pH-dependent solubility that may show drug release problems at higher pH of small intestine. Incorporation of weakly basic drugs, exhibiting pH dependent solubility, into oral Ondansetron HCl, pH independent controlled drug delivery, Hydroxypropyl-β, cyclodextrin, Multi component complexes https://www.ijper.org/article/50/4/549-562 2026-04-17T06:14:49.553107+00:00 Dissolution Rate Enhancement of Entacapone and Formulation of its Oro- Dispersible Tablets: Applying Statistical Design 2016-08-24 10.5530/ijper.50.4.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-549.pdf The major aim of the study was to enhance the solubility and dissolution rate of entacapone by complexation with cyclodextrins (β-CD/HP β-CD). Further the selected cyclodextrin complexes are deigned to formulate oro-dispersible tablets (ODTs) using selected concentration of PEG 4000 as hydrophilic polymer and crospovidone as superdisintegrant. The phase solubility behavior of entacapone in presence of various concentrations of β-CD, HP β-CD, PEG 4000, PVP and Poloxamer 188 (0.25-5% w/v) was stud Cyclodextrins, Entacapone, Inclusion complexation, Dissolution rate, Disintegration, 23 Factorial design https://www.ijper.org/article/50/4/534-541 2026-04-17T06:12:21.844958+00:00 Developing an Outcome-Based Pharmaceutical Science Curriculum: an Evaluation Based on Triangulation Method 2016-08-24 10.5530/ijper.50.4.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-534.pdf Pharmacy education in Malaysia is aiming in producing and developing pharmacists who are clinical-based and competent in the tasks related to clinical pharmacy. Since a workforce that is well-trained to function in the industrial environment as well as laboratory skills-based is in great demand, the current supply of pharmacy graduates is no longer sufficient enough to support the fast-growing industrial needs. The objective of the research is to design and evaluate an outcome-based pharmaceutic Learning Outcomes, Outcome-based Curriculum, Assessment, Pharmaceutical, Science https://www.ijper.org/article/50/4/530-533 2026-04-17T06:10:33.736378+00:00 Teaching Reform of Pharmaceutical Chemistry with PBL Method 2016-08-24 10.5530/ijper.50.4.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-530.pdf Objective: Pharmaceutical chemistry plays a key role in pharmaceutical speciality, which is aiming at making students master basic concepts, basic theory and basic skills of pharmaceutical chemistry. The teachers, however, often encounter some challenges in their teaching process, such as insufficient learning motivation for students, lack of effective means to achieve teaching goals, non-uniformity of program outcomes and ability to satisfy industry needs. It is necessary to seek for an efficie PBL, Pharmaceutical chemistry, Teaching mode, Teaching reform, Evaluation system, Pharmaceutical, speciality https://www.ijper.org/article/50/4/504-511 2026-04-17T06:07:23.698807+00:00 Assessment of Attitudes of Cuban University Pharmacy Students Toward Pharmaceutical Care 2016-08-24 10.5530/ijper.50.4.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-4-504.pdf Objective: To describe the attitude of Cuban pharmacy students toward pharmaceutical care. Methods: This study is a descriptive approach to the standard Pharmaceutical Care Attitudes Survey among professional fourth year pharmacy students in Cuba. To assess the students’ attitudes towards pharmaceutical care, a five-point Likert Scale (rating from 1 = strongly disagree to 5 = strongly agree) was utilized to measure the extent to which the students agreed on 13 statements related to pharmace Attitudes, Cuba, Pharmaceutical care, Pharmacy student`s, Survey https://www.ijper.org/synthesis-characterization-molecular-docking-studies-and-antimicrobial-evaluatio 2026-04-13T05:55:27.692666+00:00 Synthesis, Characterization, Molecular Docking Studies and Antimicrobial Evaluation of N-Benzimidazol-1-Yl-Methyl-Benzamide Derivatives 2016-08-12 10.5530/ijper.50.3.16 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-424.pdf N-benzimidazol-1-yl-methyl-benzamide derivatives (3a-3x) were synthesized by Mannich reaction and evaluated for in vitro antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus aureus, Candida albicans and Aspergillus niger. The structures of novel target compounds were elucidated by spectral and analytical techniques. Among the synthesized derivatives, 3o N-[2-(2-chloro-phenyl) benzimidazol-1-ylmethyl]-benzamide, 3q N-[2-(4-chloro-phenyl)- Mannich bases, Benzimidazole, Antibacterial activity, Antifungal activity, Docking study https://www.ijper.org/epigenetics-impacts-on-disease-susceptibility-and-pharmacotherapy 2026-04-17T05:09:27.736194+00:00 Epigenetics: Impacts on Disease Susceptibility and Pharmacotherapy 2016-08-12 10.5530/ijper.50.3.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-310.pdf Deoxyribonucleic acid (DNA) is a hereditary material comprising of all the genetic information in humans and almost all other living creatures. It is made up of subunits called genes, which have four nucleotides. MicroRNAs comprises of the short noncoding RNA. They are non-protein coding with about 18-22 nucleotides which control gene expression and activities post-transcriptionally. Notably, the whole DNA structure usually coiled itself around a protein called histone moiety. Consequently, Epigenetics, Gene-methylation, Histone, Methyl-group, Cancer, Pharmacotherapy https://www.ijper.org/factors-associated-with-the-career-preference-of-6-year-doctor-of-pharmacy-pharm 2026-04-17T05:10:48.918283+00:00 Factors associated with the Career Preference of 6-Year Doctor of Pharmacy (Pharm.D) Students in Korea: a National Survey 2016-08-12 10.5530/ijper.50.3.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-322.pdf Background: To expand the pharmacist’s role beyond dispensing prescription drugs in community pharmacies, a 6-year doctor of pharmacy (PharmD) programme was introduced in 2011 and replaced the traditional 4-year bachelor pharmacy programme in Korea. This study investigated the career preference of students at newly implemented 6-year PharmD programmes in Korea. Methods: A cross-sectional survey was administered to PharmD students enrolled in all pharmacy schools in Korea as of July 2014. Da Career, Doctor of pharmacy program, Pharmacy students, Korea https://www.ijper.org/learning-style-preferences-of-undergraduate-pharmacy-students-in-a-malaysian-pub 2026-04-17T05:12:07.418587+00:00 Learning Style Preferences of Undergraduate Pharmacy Students in a Malaysian Public University 2016-08-12 10.5530/ijper.50.3.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-330.pdf Objectives: To compare the learning style preferences among pharmacy students at different stages of academic course and to determine the demographic variables that significantly influence the learning style preferences of these students. Methods: A 24-item self-report survey instrument, including the validated Pharmacists’ Inventory of Learning Styles (PILS), was administered to all year 1 to year 4 pharmacy students at Universiti Teknologi MARA, Malaysia. Data (e.g. demographic variables, Assimilator, Converger, Learning styles, Pharmacy, PILS https://www.ijper.org/voluntary-work-of-pharmacy-students-in-two-regions-of-south-korea-without-the-se 2026-04-17T05:14:18.992406+00:00 Voluntary work of pharmacy students in two regions of South Korea without the separation of the dispensary from medical practice 2016-08-12 10.5530/ijper.50.3.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-352.pdf Background: Participation in a medical volunteer work positively affects some of the beliefs and perceptions of pharmacy students. However, the volunteer activities by pharmacy students have been rarely performed and studied in Korea. The objectives of this study were to introduce the volunteer activities by pharmacists and pharmacy students at the medically underserved regions without separation of prescribing and dispensing in Korea and to determine health conditions and prevalence and ma Volunteer works, Korean pharmacy students, Medically underserved areas, Advanced pharmacy practice experience https://www.ijper.org/chondroprotective-and-anti-inflammatory-activities-of-extracts-from-semen-sojae 2026-04-17T05:23:18.357822+00:00 Chondroprotective and Anti-Inflammatory Activities of Extracts from Semen Sojae Germinatum on IL-1 β- Stimulated Human Osteoarthritis Chondrocytes 2016-08-12 10.5530/ijper.50.3.12 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-397.pdf Our previous study showed that Semen sojae germinatum (SSG), a soy-derived Chinese medicinal material, have potential benefits for knee osteoarthritis (OA). This study was undertaken to identify the major effective sub-fraction of SSG. The 95% ethanol extract of SSG was successively fractionated into petroleum ether, ethyl acetate, n-butanol and aqueous fractions. Then we examined the effect of fractions on the inflammatory response and cell proliferation of primary human osteoarthritic cho Semen sojae germinatum, Extract, Osteoarthritis, Chondrocytes, Inflammatory, response, Proliferation https://www.ijper.org/application-of-tlc-densitometry-for-analysis-of-estradiol-hemihydrate-in-dosage 2026-04-17T05:35:27.912474+00:00 Application of TLC-Densitometry for Analysis of Estradiol Hemihydrate in Dosage Forms 2016-08-12 10.5530/ijper.50.3.23 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-482.pdf The aim of current study was the application of validated TLC-densitometric method for identification and determination of Estradiol hemihydrate in dosage forms. The applied TLC conditions were: Silicagel G60F254 glass plates; mobile phase: chloroform : acetone = 90 : 10 v/v, migration distance of mobile phase: 120 mm, UV-detection at  = 254 nm. All of the experimental results for the content of Estradiol hemihydrate correspond to the respective confidence interval: Estrofem table: 1.78 mg ÷ 2. Estradiol hemihydrate, TLC, Densitometry, Tablets, analysis, Determination https://www.ijper.org/neuroprotective-activity-of-garcinia-pedunculata-roxb-ex-buch-ham-fruit-extract 2026-04-17T05:28:02.032123+00:00 Neuroprotective Activity of Garcinia pedunculata Roxb. ex Buch.-Ham. Fruit Extract Against Aluminium Chloride Induced Neurotoxicity in Mice 2016-08-12 10.5530/ijper.50.3.17 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-435.pdf Aluminium chloride (AlCl3) is a known potent environmental neurotoxin causing progressive neurodegenerative changes in brain. The present study was aimed to evaluate the neuroprotective activity of aqueous extract of fruit rind of Garcinia pedunculata on chronic exposure of aluminium chloride induced neurotoxicity in Swiss albino mice. Albino mice were categorized into four different groups; Group 1–served as vehicle control, Group 2 mice were administered with AlCl3 40 mg/kg body weight i.p. fo Acetylcholine esterase, Aluminium chloride, Garcinia pedunculata, Lipid, peroxidation, Neurotoxicity https://www.ijper.org/challenges-and-opportunities-in-integrated-curriculum-of-health-professions-educ 2026-04-17T05:40:52.489723+00:00 Challenges and Opportunities in Integrated Curriculum of Health Professions Education – A Critical View 2016-08-12 10.5530/ijper.50.3.26 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-502.pdf Integrative learning is a well known learning theory that describes a movement toward integrated lessons, that mean the concept of ‘brought together in to a whole’ and thus helping students make connections across curricula. The integrated curriculum, a dimension of teaching and learning processin developed countries, and is defined as ‘an education system that interlinks different area of learning with a definite line across subject-matter requirement on unifying concept. 1 The concepts of inte Integrative learning, curriculum, teaming https://www.ijper.org/comparative-pharmacokinetic-study-and-quantification-of-ibuprofen-released-from 2026-04-17T05:29:15.110943+00:00 Comparative Pharmacokinetic Study and Quantification of Ibuprofen released from Interpenetrating polymer Network Beads of Sodium Carboxymethyl Xanthan and Sodium Alginate 2016-08-12 10.5530/ijper.50.3.18 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-442.pdf Aim: The purpose of this study was to determine the pharmacokinetic parameters of ibuprofen (IBP) in rabbits following administration of the drug-loaded interpenetrating network (IPN) beads and to compare the bioavailability of the drug from IPN beads with that from pure IBP and IBP Suspension. Materials and Methods: IPN beads, sodium carboxymethyl xanthan and sodium alginate was prepared by inotropic gelation process using AlCl3 as a cross linking agent. The plasma drug concentration was determ IPN, Pharmacokinetic, Relative bioavailability, HPLC, Ibuprofen https://www.ijper.org/pharmacy-value-added-services-early-begininings-current-implementation-and-chall 2026-04-13T05:55:27.692666+00:00 Pharmacy Value Added Services: Early Begininings, Current Implementation, and Challenges from the Malaysian Experience 2016-08-12 10.5530/ijper.50.3.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-335.pdf Background: In a large natural experiment, Pharmacy Value Added Services (PVAS) was introduced by the Malaysian Pharmaceutical Services Division, Ministry of Health Malaysia to improve the delivery of pharmaceutical care to patients. PVAS in the Malaysian context and definition refers to a group of new innovative pharmacy services including Pharmacy Drive Through, Postal Medicine, Integrated Drug Dispensing System, and SMS and Collect. Despite the convenience and advantages of PVAS, patient Pharmacy Value Added Services, Pharmacy Practice, Implementation of, services, Malaysia, new services adoption, community pharmacy https://www.ijper.org/synthesis-evaluation-and-molecular-docking-study-of-some-new-2-25-disubstituteda 2026-04-17T05:33:27.238232+00:00 Synthesis, Evaluation and Molecular Docking Study of Some New 2-[(2,5-Disubstitutedanilino) Phenyl] Acetic Acid Derivatives 2016-08-12 10.5530/ijper.50.3.21 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-465.pdf In the present study synthesis and antimicrobial activity of some new 2-[(2,5-disubstitutedanilino)phenyl]acetic acid derivatives 5a-f are described. The structures of the newly synthesized compounds were confirmed by FTIR, 1H NMR, 13C NMR, mass and elemental analysis. All compounds were screened for antitubercular and antimicrobial activity. Molecular modeling studies were performed to dock compounds into the ecKAS III binding site, which suggested probable inhibition mechanism. The resul 1, 3, 4-Thiadiazole, Phenacyl bromide, Molecular Docking, Antitubercular, activity, Antimicrobial activity, Mycobacterium tuberculosis https://www.ijper.org/development-of-transdermal-delivery-system-of-dexamethasone-palonosetron-and-apr 2026-04-20T04:39:11.323202+00:00 Development of Transdermal Delivery System of Dexamethasone, Palonosetron and Aprepitant for Combination Antiemetic Therapy 2016-08-12 10.5530/ijper.50.3.22 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-472.pdf Purpose: The objective of this study was to assess the possible transdermal delivery for combination antiemetic therapy of dexamethasone, palonosetron and aprepitant, commonly prescribed in chemotherapy induced nausea and vomiting. Methods: Pluronic lecithin organogel formulation was optimized to incorporate all the three drugs. The influence of formulation parameters like drug concentration (1-5% w/w) and permeation enhancers (oleic acid, n-methyl-2-pyrrolidone, propylene glycol and polyet Transdermal, dexamethasone, palonosetron, aprepitant, organogel, enhancer https://www.ijper.org/estimation-of-antioxidant-activity-and-total-phenol-flavonoid-content-among-natu 2026-04-17T05:39:02.361454+00:00 Estimation of Antioxidant Activity and Total Phenol, Flavonoid Content among Natural Populations of Caper (Capparis moonii, Wight) from Western Ghats Region 2016-08-12 10.5530/ijper.50.3.25 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-495.pdf Antioxidant activity (%) of Capparis moonii, Wight leaves and stem collected from Amboli, Western Ghat (India) was measured using DPPH , Phosphmolybdenum reduction, FRAP, Reducing power assay and H2O2 radical scavenging assay along with its total phenol and flavanoid content. Current research focuses on exploring antioxidants of plant origin. Method: In this study, the antioxidant activity of hexane, chloroform, ethylacetate, methanol and aqueous crude extracts of leaves and stem of Capparis moo Phenols, Flavanoids, Antioxidant activity, Capparis moonii, Wight https://www.ijper.org/effects-of-nigella-sativa-kalonji-and-honey-on-lipid-profile-of-hyper-lipidemic 2026-04-13T05:55:27.692666+00:00 Effects of Nigella sativa (Kalonji) and Honey on Lipid Profile of Hyper lipidemic Smokers 2016-08-12 10.5530/ijper.50.3.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-376.pdf Background: Hyper lipidemia refers to the excess of lipids in the blood of patients. The present study was carried out to investigate the effect of Nigella sativa (kalonji) and honey as compared with Atorvastatin on the lipid profile of hyper lipidemia patients with habit of smoking. Methodology: Purposes, 60 patients (3 groups of 20) of 35-65 years were selected. These patients were treated with 1 g of Nigella sativa (kalonji) seed, one tablespoon of honey, and Atorvastatin 10 mg daily in Alternative and Complementary Medicine, Atorvastatin, Honey, Hyper lipidemia, Smoking, Kalonji, Preventive Medicine, Smoking https://www.ijper.org/comparison-between-hplc-and-hptlc-densitometry-for-the-determination-of-11-keto 2026-04-13T05:55:27.692666+00:00 Comparison Between HPLC and HPTLC Densitometry for the Determination of 11-keto β-boswellic acid and 3- acetyl-11-keto β-boswellic acid from Boswellia serrata Extract 2016-08-12 10.5530/ijper.50.3.15 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-418.pdf Objective: Boswellic acids (BAs) are active constituents of plant Boswellia serrata. In the present study boswellic acids were extracted from Boswellia serrata and dry methanolic extracts were quantified by HPLC and HPTLC. Method: A gradient HPLC method was used for the quantification of the boswellic acids; 11-keto-β-boswellic acid (KBA) and 3- acetyl-11-keto-β-boswellic acid (AKBA). A direct HPTLC assay was developed for the determination of KBA and AKBA at 254 nm. The UV detection of ana Boswellic acids, Quantification, Extraction, Boswellia serrata extract https://www.ijper.org/a-diterpenoid-taxoquinone-from-metasequoia-glyptostroboides-with-pharmacological 2026-04-17T05:32:33.935991+00:00 A Diterpenoid Taxoquinone from Metasequoia glyptostroboides with Pharmacological Potential 2016-08-12 10.5530/ijper.50.3.20 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-458.pdf Background: The ubiquitin-proteasome pathway plays an important role in selective protein degradation and regulates multiple cellular processes, including cell cycle progression, proliferation and apoptosis. Cancer cells are more sensitive to the pro-apoptotic effects of proteasome inhibition than normal cells, hence, proteasome inhibitors can be used as novel anticancer drugs. Further, influenzacommonly known as “flu” is a contagious respiratory disease caused by sub-type of influenza A virus H Anticancer, Antiviral, Taxoquinone, Diterpenoid, Metasequoia glyptostroboides https://www.ijper.org/development-and-validation-of-a-rp-hplc-method-for-the-simultaneous-estimation-o 2026-04-17T05:38:12.648308+00:00 Development and Validation of a RP-HPLC Method for the Simultaneous Estimation of Sulfadoxine and Pyrimethamine in Combined Dosage Tablets 2016-08-12 10.5530/ijper.50.3.24 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-489.pdf A new simple, sensitive and reproducible RP-HPLC method for the simultaneous estimation of sulfadoxine and pyrimethamine in pharmaceutical formulations was developed and validated. The separation was carried out on Zorbax Eclipse Plus C18, 3.5 µm (4.6×100 mm) column with acetonitrile: 20 mM sodium acetate buffer pH 6, 80:20% v/v as the mobile phase at the flow rate of 1 ml/min. The eluent detection was carried out using UV-Visible PDA detector at 224 nm. The retention time of sulfadoxine a RP-HPLC, Sulfadoxine, Pyrimethamine, Validation, Stress-induced stability https://www.ijper.org/impact-of-clinical-pharmacist-counselling-and-education-on-quality-of-life-in-pa 2026-04-13T05:55:27.692666+00:00 Impact of Clinical Pharmacist Counselling and Education on Quality of Life in Patients with Acute Coronary Syndrome 2016-08-12 10.5530/ijper.50.3.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-360.pdf Objectives: To assess the impact of clinical pharmacist counselling and education on Quality of Life (QoL) of patients with acute coronary syndrome (ACS). Methodology: A prospective interventional study was conducted for a period of 8 months. The ACS patients were categorized into intervention and control groups by randomization process. The intervention group was given patient counselling and patient information leaflets along with the usual care while the control group received only the u Pharmacist Counselling, Patient Education, Patient Information Leaflet, Interventional study, Quality of Life https://www.ijper.org/administration-of-fresh-juice-of-tinospora-cordifolia-decreases-levels-of-urinar 2026-04-17T05:30:41.739113+00:00 Administration of Fresh Juice of Tinospora cordifolia Decreases Levels of Urinary Markers of Peroxisome Proliferator-Activated Receptors in Hyperlipidemic Patients 2016-08-12 10.5530/ijper.50.3.19 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-451.pdf Objective: Tinospora cordifolia (Willd.) Miers juice (TCJ) is known for its anti-hyperlipidemic properties. This study was aimed to validate the efficacy of TCJ to activate PPARα in vivo in hyperlipidemic (HPL) patients. Materials and Methods: HPL (n=20) and healthy (n=22) volunteers were enrolled in the study. HPL patients were treated with TCJ for 14 days. The fasting urine and blood samples were collected on 0 and 14th day for analysis. The blood samples were used for biochemical analysi Tinospora cordifolia, Urinary biomarkers, LC-ESI-QTOFMS, PPAR-alpha, Fatty acids ß oxidation, Oxidative stress https://www.ijper.org/a-novel-rp-hplc-method-development-and-validation-for-estimation-of-nicoumalone 2026-04-17T05:24:05.24532+00:00 A Novel RP-HPLC Method Development and Validation for Estimation of Nicoumalone in Bulk drug and Formulation 2016-08-12 10.5530/ijper.50.3.13 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-403.pdf Objective: The objective of this study is to validate a simple, precise, and accurate isocratic reverse phase high performance liquid chromatography (RP-HPLC) method for estimation of nicoumalone in bulk and tablet dosage form. Method & Results: The quantification is carried out by using C18 column (inertsilR ODS-3V column, 250¥4.6 mm, 5 μm). A mixture of Acetonitrile: Potassium dihydrogen phosphate buffer 10 mM, pH 6 adjusted using 0.1 N KOH in 50:50 v/v ratio used as mobile phase. The flo Nicoumalone, RP-HPLC method and Validation, ICH, Estimation, Dosage, Form https://www.ijper.org/antimicrobial-and-tnf-inhibitory-activity-of-barleria-prionitis-and-barleria-gra 2026-04-17T05:25:01.723444+00:00 Antimicrobial and TNF α Inhibitory Activity of Barleria prionitis and Barleria grandiflora: A Comparative Study 2016-08-12 10.5530/ijper.50.3.14 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-409.pdf Background: Leaf juice as well as leaves of Barleria prionitis Linn and Barleria grandiflora Dalz (Acanthaceae) is used by rural people across various regions of India in treatment of oral ailments such as dental troubles, gum ailments, pyorrhoea, dental carries and mouth ulcers. Methods: An antimicrobial activity was carried on aqueous and ethanolic extracts of both herbs and compared with standard chlorhexidine. Cell line study was carried using Human Gingival Fibroblast on ethanolic extr Barleria prionitis, Barleria grandiflora, Antimicrobial, Cytotoxicity, TNF-α, Inhibition https://www.ijper.org/characteristics-and-career-plans-of-korean-international-students-and-graduates 2026-04-13T05:55:27.692666+00:00 Characteristics and Career Plans of Korean International Students and Graduates of Doctor of Pharmacy Program in the United States 2016-08-12 10.5530/ijper.50.3.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-344.pdf Introduction: This study was designed to identify the characteristics and career plans of Korean international students and graduates of the PharmD program in the United States. Methods: A questionnaire was administered to the online community of Korean international students and graduates of the US PharmD program. Results: Korean students and graduates were highly satisfied with the quality of the PharmD program in the United States but their level of anxiety regarding employment was high. PharmD, Korean, International student, Career, United States https://www.ijper.org/anthocyanin-improving-metabolic-disorders-in-obese-mice-from-aornia-melanocarpa 2026-04-13T05:55:27.692666+00:00 Anthocyanin Improving Metabolic Disorders in Obese Mice from Aornia melanocarpa 2016-08-12 10.5530/ijper.50.3.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-368.pdf The aim of this study was to investigate the effects of Aornia melanocarpa anthocyanin (AMA) on symptoms of metabolic syndrome in obese mouse. AMA can reduce weight. Blood glucose and lipid metabolism were significantly improved, and so as hepatic lipid metabolism. This suggesting AMA is a strong indication of improved glucose lipid metabolism and weight. Moreover, both morphologic and histological detections indicated that AMA significantly reversed obsity induced hepatic steatosis and liv Metabolic disorders, Obese, Aornia melanocarpa, Anthocyanin, Mechnism https://www.ijper.org/surface-modification-of-carbon-nano-tubes-with-nystatin-for-drug-delivery-applic 2026-04-17T05:20:28.080462+00:00 Surface Modification of Carbon Nano tubes with Nystatin for Drug Delivery Applications 2016-08-12 10.5530/ijper.50.3.10 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-385.pdf The present study is an approach to describe the increased antifungal efficacy of Nystatin by conjugation with functionalized multi-walled carbon nano tubes. Functionalized Multi-walled carbon nano tubes are acts as nano vectors for the delivery of therapeutic molecules by conjugation. Structural properties of carbon nano tubes have emerged as a new alternative and efficient tool for transporting and translocating therapeutic molecules to target moieties. Carbon nano tubes are easily cross Multi-walled carbon nanotubes, Nystatin, Antifungal, Surface Modification, Conjugation https://www.ijper.org/evaluation-of-anti-obesity-effect-of-fattolin-a-polyherbal-formulation-in-proges 2026-04-17T05:21:45.00616+00:00 Evaluation of Anti-obesity Effect of Fattolin, a Polyherbal Formulation in Progesterone Induced Obesity in Mice 2016-08-12 10.5530/ijper.50.3.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-3-391.pdf Progesterone imbalance modulates lipids and fats metabolism leading to obesity. Polyherbal formulation, Fattolin is currently being used in the treatment of obesity but not reported scientifically. Thus the present study investigates the anti-obesity effect of Fattolin in progesterone induced obesity model. Female Swiss albino mice were divided in four groups (n=6) and treated for 28 days, Group I received 2% gum acacia (10 ml/kg); Group II, III and IV received progesterone (10 mg/kg) subcu Fattolin, Progesterone, Obesity, Total cholesterol, Body weight https://www.ijper.org/article/50/1/80-89 2026-04-16T10:03:09.525592+00:00 Challenges Militating against Sustainable Economic Development Potential of African Aromatic, Beverage and Medicinal herbs: A South African Perspective 2016-07-16 10.5530/ijper.50.1.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-80.pdf Context: Medicinal and Aromatic plants (MAPs) extracts have become an essential part of exports in the developing countries. Due to the rich diversity of MAPs and as consumers of natural products increase, there is a potential to exploit this niche market. Aim: The objective(s) of the study was to identify and analyze challenges militating against economic development potential of African aromatic, beverage and medicinal herbs industry. Settings and Design: The study was undertaken in three (3) Medicinal Aromatic Plants, Commercialization, Challenges, South Africa https://www.ijper.org/article/50/1/179-189 2026-04-16T10:04:10.223679+00:00 Screening of Ethanolic extract of Diospyros malabarica Desr. Bark for Anti-diabetic and Antioxidant Potential 2016-07-16 10.5530/ijper.50.1.22 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-179.pdf Objective: Evaluation of ethanolic extract of Diospyrous malabarica Desr. Bark for anti-diabetic and antioxidant potentials. Materials and Methods: Diospyros malabarica Desr. bark ethanol extract was studied for the OGTT study and acute and sub-acute effects on alloxan induced diabetic rats. Blood glucose levels, Serum lipid profiles and histopathological study of pancreas were performed. The Bark extract was also studied for DPPH radical scavenging potential. Results: Ethanolic extract of bark Alloxan induced diabetic rats, Antioxidant, Antidiabetic, Diospyros malabarica Desr, Hypoglycemic https://www.ijper.org/article/50/1/170-178 2026-04-16T10:04:04.200501+00:00 Modulatory Role of Selenium Nanoparticles and Grape Seed Extract Mixture on Oxidative Stress Biomarkers in Diabetic Irradiated Rats 2016-07-16 10.5530/ijper.50.1.21 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-170.pdf Introduction: Diabetes is a metabolic disorder of several etiologies, many oral anti-hyperglycemic agents such as sulfonylurea, biguanides are obtainable, but these agents have side effects, thus there is need of a new natural anti-hyperglycemic agent. Methods: The present study was performed to evaluate the protective role of selenium nanoparticles-grape seed extract (SeNPs-GSE) mixture in ameliorating the changes in the oxidative stress biomarkers induced by gamma radiation in diabetic rats. E Diabetes mellitus, Selenium nanoparticles, Grape seed extract, Oxidative stress, Vitamin C, E https://www.ijper.org/article/50/1/24-33 2026-04-16T10:02:13.42551+00:00 Review of Pharmacy Professionals and Drug Jurisprudence to Achieve the Millennium Development Goals in Punjab Province of Pakistan 2016-07-16 10.5530/ijper.50.1.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-24.pdf The current health practice of Punjab Province of Pakistan needs a serious attention to control the unnecessary drug usage, improve pharmaceutical care and establish excellent public health system. Hence, the health officials of Govt. of Pakistan have established “Drug Regulatory Authority”, and Punjab Health Department has chalked out Punjab Drug Rule, 2007 to deployed a revised health structure in Punjab. But, unluckily, the medical physicians, drug store owners and bureaucracy have not put it Drug resistance, Millennium Development Goals, Drug rule, Pharmaceutical, care, Clinical pharmacy https://www.ijper.org/article/50/1/116-122 2026-04-16T10:03:32.400498+00:00 Molecular Docking Study of Cassia tora, Brassica campestris and Calotropis procera as Acetylcholinesterase Inhibitor 2016-07-16 10.5530/ijper.50.1.15 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-116.pdf Introduction: Acetylcholinesterase inhibitor is the only standard and FDA approved drug therapy for Alzheimer’s disease and its associated disorders. Numerous plants and their phytoconstiuents are being reported to inhibit acetylcholinesterase. To get insight of the intermolecular interactions, the molecular docking studies are performed at active site of acetylcholinesterase enzyme. Aim: In this study, an attempt is made for identification of potential ligands from selected 30 compounds which a Alzheimer’s disease, Molecular Docking, Phytoconstituent, Virtual screening, Cognition enhancer https://www.ijper.org/IndJPharmEduRes-50-1-1 2026-04-16T10:01:38.509921+00:00 Public Health and Patient Care Aspects in Indian Pharmacy Curricula: A Comparison with USA, Finland and Denmark 2016-07-16 10.5530/ijper.50.1.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-1.pdf Aim(s): This study was designed to compare Indian pharmacy curricula with Pharmacy curriculum of USA, Finland and Denmark to assess differences with a focus on pharmaceutical policies and public health, patient care and pharmacy practice aspects in the programs. Study Design: This is a programmatic research conducted between March 2013 and August 2014. Methods: Curricula of pharmacy programs leading to registered pharmacist in India, USA, Finland and Denmark were selected. By using conversion re Curriculum Comparison, Pharmacy Education, Pharmacy Curriculum, Patient, Care, Public Health, India https://www.ijper.org/article/50/1/146-158 2026-04-16T10:03:54.058904+00:00 Evaluation of Gum Katira as a Model Sustained Release Adjuvant in the Preparation of Etodolac Loaded Microsphere 2016-07-16 10.5530/ijper.50.1.19 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-146.pdf Aims: The aim of present study was to evaluate Gum Katira obtained from the plant Cochlospermum religiosum (Family Cochlospermaceae) as a matrix forming pharmaceutical excipient for a novel drug delivery system. Materials and Methods: Gum Katira was used for the drug release retarding material in microsphere formulation using Etodolac as a model drug. Etodolac was found to be compatible with the matrix material Gum Katira by conducting the various physiochemical and instrumental analysis. Result Etodolac, Gum Katira, Gum Matrix, Rheogram, Sustained release https://www.ijper.org/article/50/1/130-137 2026-04-20T04:38:36.58294+00:00 Development of Transdermal Delivery System of Vildagliptin and Its Comparison with Oral Therapy 2016-07-16 10.5530/ijper.50.1.17 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-130.pdf Purpose: The long term oral therapy of vildagliptin is associated with potential hepatotoxicity and low patient compliance. This study aims at development of a drug in adhesive transdermal patch system of vildagliptin using pressure sensitive acrylic polymers and compare the pharmacokinetics with oral therapy. Methods: The prospective of different chemical enhancers in improving the transport of vildagliptin was assessed ex vivo. In vivo permeation studies in rats were performed using patch syst Transdermal, Adhesive, Vildagliptin, Enhancer, Flux, Pharmacokinetics https://www.ijper.org/article/50/1/123-129 2026-04-16T10:03:38.786249+00:00 Anti-Tumor Activity of Viper Snake Venom Photo-products SV1 and SV2 against Ehrlich Ascites Carcinoma in Mice 2016-07-16 10.5530/ijper.50.1.16 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-123.pdf Objectives: To evaluate antitumor activity potential of viper venom photoproducts SV1 and SV2 against Ehrlich ascites carcinoma in mice. Materials and Methods: Viper venom photoproducts SV1 (Vipera russelli ) and SV2 (Echis carinatus) were generated by exposure of the venoms to UV sensitized methylene blue for 15 min. and 90 min. at 370C respectively. The Antitumor activity of SV1 and SV2 at two concentrations (1/10th and 1/20th dilutions) was evaluated on Ehrlich Ascites Carcinoma (EAC) inocula Non-herbal, Vipera russelli, Echis carinatus, Methylene blue, Ehrlich Ascites Carcinoma https://www.ijper.org/article/50/1/138-145 2026-04-16T10:03:49.098119+00:00 Goodness of Fit Model Dependent Approaches of Controlled Release Matrix Tablets of Zidovudine 2016-07-16 10.5530/ijper.50.1.18 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-138.pdf Objectives: The objective of the study was to develop controlled release matrix tablet of zidovudine and to understand the release kinetics of drug by applying several mathematical model dependant and independent approaches. Various equations and models are developed for evaluating the drug release. Comparison of original and predicted release profile was most common way for selection of optimum formulation. Methods: In this study drug release profiles are characterized by using several para Area under curve, Goodness of fit, Higuchi model, Matrix tablet, Sum square residual https://www.ijper.org/article/50/1/190-197 2026-04-16T10:04:15.248715+00:00 Synthesis and In vitro Cytotoxicity of a Novel Efficient Cisplatin-loaded Poly N-butyl Cyanoacrylate 2016-07-16 10.5530/ijper.50.1.23 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-190.pdf Purpose: Typically, drug-loaded polymer colloidal carriers are synthesized by the drug entrapment during anionic emulsion polymerization. The purpose of this study was to trial the ability of Cisplatin-loaded Poly Butyl Cyanoacrylate (PBCA) nanoparticles. Methods: The cytotoxicity of Cisplatin-loaded PBCA nanoparticles was evaluated by MT assay. The Polymeric nanoparticles have been characterized using TEM, SEM, FTIR and DLS. Results: Polymeric nanoparticles with loaded and unloaded drug prepare Cisplatin, Drug delivery, Emulsion polymerization, Encapsulation, Polymeric Nanoparticles https://www.ijper.org/article/50/1/159-169 2026-04-20T04:55:50.820095+00:00 Natural Polymer Based Mucoadhesive Hydrogel Beads of Nizatidine: Preparation, Characterization and Evaluation 2016-07-16 10.5530/ijper.50.1.20 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-159.pdf Background: Dosage forms which precisely control the release rates and targets drugs to a specific body site have made enormous impact in the formulation and development of novel drug delivery systems. Methods: A prolonged release mucoadhesive hydrogel system of nizatidine was prepared by ionotropic gelation and polyelectrolyte complexation technique using natural, biodegradable polymers with or without chitosan. Prepared formulations were subjected to in vitro evaluation and several characteriz Chitosan, ionotropic gelation, Mucoadhesion, Nizatidine, Sodium alginate https://www.ijper.org/article/50/1/205-211 2026-04-16T10:04:24.99775+00:00 Development and Validation of Stability-Indicating HPLC-DAD Method for Simultaneous Determination of Emtricitabine, Elvetegravir, Cobicistat and Tenofovir in their Tablet Dosage Forms 2016-07-16 10.5530/ijper.50.1.25 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-205.pdf A Simple, accurate, specific and rugged reverse phase liquid chromatographic method was developed for the simultaneous estimation of Emtricitabine, Elvetigravir, Cobicistat and Tenofovir in bulk and tablet dosage form. A reverse phase gradient program has been developed to separate the all four active ingredients. The mobile phase consisting of 0.05M Phosphate buffer pH 3.0 (adjusted with dilute phosphoric acid) and Acetonitrile in the ratio 95:5 from 0 min to 4 minutes, further increased the Ac Emtricitabine, Elvetigravir, Cobicistat, Tenofovir, HPLC-DAD, Tablet https://www.ijper.org/article/50/1/70-79 2026-04-16T10:03:02.556566+00:00 Risk of Attritionfrom Master of Science in Pharmacy Degree Program: 15-year Predictive Evaluation 2016-07-16 10.5530/ijper.50.1.10 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-70.pdf Aim: Evaluation of the selected socio-demographic factors and admission criteria for the MA pharmaceutical studies on the risk of attrition during studies at the Faculty of Pharmacy at the Medical University of Warsaw (MUW). Materials and Methods:1598 students who undertook studies of pharmacy between the years 2000- 2009; observation of a full education cycle between October 1st 2000 and March 31st 2015. A model of logistic regression was used to evaluate predictive factors that are of potentia Pharmacy education, Retention, Student dropouts, Attrition, Educational status, Regression analysis https://www.ijper.org/article/50/1/103-108 2026-04-16T10:03:21.381521+00:00 An Innovative approach for Pharmacists’ Continue Education: Massive Open Online Courses, A Lesson Learnt 2016-07-16 10.5530/ijper.50.1.13 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-103.pdf Objective: To develop a massive open online course (MOOC) for pharmacists as an innovative continue education. Design: A MOOC titled “Special Topics in Clinical Pharmacy” for pharmacists as a professional continue education program was developed and evaluated. It was implemented with case-based lecture videos and interactive quizzes. Content was delivered in weekly base. A Pre-course survey, a post-course survey, and a learner-driven final assessment were conducted accordingly. Results: The prim Profession-Pharmacist, Innovative educational interventions, Online/computer-based education, Self-directed, learning, MOOCs https://www.ijper.org/article/50/1/63-69 2026-04-16T10:02:56.087348+00:00 An Analysis of Pharmacy Students’ Social Networking Service Activities and Perceptions Regarding E-Professionalism under the Newly Implemented 6-year Pharmacy Educational System in South Korea 2016-07-16 10.5530/ijper.50.1.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-63.pdf Background: In the transitional period of Korean pharmacy educational system from 4-year to 6-year, it is crucial to provide pharmacy students with a proper training in professionalism in order for them to succeed as future medication experts appropriately prepared for their attitudes and behaviors online as well as off-line. Consequently, it is necessary to comprehend current social networking service (SNS) activities and perceptions of pharmacy students regarding e-professionalism. The aims of Social networking service, Pharmacy students, e-professionalism, Social media, Perception https://www.ijper.org/article/50/1/51-62 2026-04-16T10:02:47.324992+00:00 Role of Pharmacists in National Public Health Programs in India: A Survey on Pharmacy Students’ Perceived Knowledge and Attitude 2016-07-16 10.5530/ijper.50.1.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-51.pdf Objective: An attempt was made to explore the awareness, perceived knowledge and attitude of Indian pharmacy students on National Public Health Programs (NPHPs). Methods: This study was a cross-sectional classroom survey among final year D Pharm, B Pharm and Pharm D students in India. A survey tool was prepared to assess: (i) pharmacy students’ perceived knowledge and attitude towards NPHPs in general; (ii) perceived knowledge on individual NPHPs. The survey tool was distributed to 326 students Pharmacy Education, Pharmacy Students, Knowledge and Attitude, Public Health, Pharmacist role in, public health https://www.ijper.org/article/50/1/34-38 2026-04-16T10:02:20.281813+00:00 Implementation of Total Quality Management in Higher Pharmaceutical Education: Opportunity and Challenge 2016-07-16 10.5530/ijper.50.1.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-34.pdf Introduction: Higher pharmaceutical education in China has made a great development in recent years. A few problems, such as unevenness of school-running level, lack of students innovation and deficiency of teaching effect, are also exposed in its rapid development. The reasons for these challenges are also revealed that old teaching mode and increasing enrollment scale in China's university may be the primary causes. Methods: To face these problems, some measures should be taken. Total quality Higher pharmaceutical education, Innovative ability, Professional ethics, Total quality management https://www.ijper.org/article/50/1/9-16 2026-04-16T10:02:00.747228+00:00 Job Satisfaction among Indian Pharmacists: An Exploration of Affecting Variables and Suggestions for Improvement in Pharmacist Role 2016-07-16 10.5530/ijper.50.1.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-9.pdf Objectives: The purpose of this study was to determine the level of job satisfaction among Indian pharmacists, and factors associated with job satisfaction. The study also explored the suggestions of pharmacist to improve the profession of pharmacy in India. Methods: A cross sectional web-based study was conducted on working pharmacists in India, using a validated questionnaire for a period of 2 months. The participants were contacted via email and social websites and data was collected by using factors, India, job satisfaction, pharmacists, Survey, questionnaire https://www.ijper.org/article/50/1/212-214 2026-04-16T10:04:32.004621+00:00 Pharmacovigilance Programme of India: System put in place to Report Adverse Drug Reactions 2016-07-16 10.5530/ijper.50.1.26 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-212.pdf Adverse drug reaction (ADRs) is response to a drug which is noxious and unintended and which occurs at doses normally used in human for the prophylaxis, diagnosis or treatment of disease, or for the modification of physiological function.1 ADRs are one of the major public health issues and found to cause of morbidity and mortality.2 The impact of ADRs in India is significant and leads to the enormous burden to the public. Therefore, Ministry of Health & Family Welfare (MoHFW), Government of Indi https://www.ijper.org/article/50/1/39-45 2026-04-16T10:02:26.68133+00:00 Quality by Design in Education (QbDE)–A Possible Futuristic Approach to Improve Current Status of Pharmaceutical Education in India 2016-07-16 10.5530/ijper.50.1.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-39.pdf Pharmacy education in India needs a drastic change. In the last decade, there has been uncontrolled spurt in number of pharmacy colleges. But only few of them have infrastructure and experienced faculty members to train and teach the students to become a quality professional. The situation is such that most college managements resort to one or other type of malpractice to seek regulatory approvals and to attract students to their institutions. This must stop and both regulatory bodies and manage Pharmaceutical education, Explosion, Outcomes, Quality-by-design, Implementation https://www.ijper.org/article/50/1/198-204 2026-04-16T10:04:20.024962+00:00 Quantitative Structure Activity Relationship of 2, 5, 6–Trisubstituted imidazo (2, 1-b)-1, 3, 4–Thiadiazole as Anticancer Compounds 2016-07-16 10.5530/ijper.50.1.24 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-198.pdf Imidazoles being good Pharmacophore for anticancer series were exploited for their potential in the present study. Some new 2,5,6–trisubstituted imidazo (2,1-b)-1,3,4–thiadiazole possesing antineoplastic potential against 3 cell lines i.e. murine leukemia cells (L1210/0) and human T- lymphocyte cells (Molt4/C8 and CEM/0) were selected for studies. The IC50 values were taken along with the structures and a quantitative structure activity relationship was established for these novel 2,5,6-trisubst Antineoplastic agent, CODESSA, Dragon, Imidazo-thiadiazole, PLSR and PCR QSAR https://www.ijper.org/article/50/1/17-23 2026-04-16T10:02:07.094212+00:00 Impact of Task-based Checklist Scoring and Two Domains Global Rating Scale in Objective Structured Clinical Examination of Pharmacy Students 2016-07-16 10.5530/ijper.50.1.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-17.pdf Introduction: Global ratings are station-independent scales identifying general areas of competence, such as communication, rapport and similar constructs that may not be well captured in a checklist item. Global ratings seem to have psychometric possessions that are as noble as or healthier than those of checklists, whether used in conjunction with a checklist scoring system or on their own. Methods: This was a retrospective study. The results of second year pharmacy students’ end of semester f Global rating scale, Malaysia, OSCE, Pharmacy students, Pharmacy curriculum, Task-based checklist https://www.ijper.org/article/50/1/46-50 2026-04-16T10:05:20.010942+00:00 Application Research on the Three Independent Learning Method in the Pharmaceutical Management Experimental Course Teaching 2016-07-16 10.5530/ijper.50.1.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-46.pdf Background: In order to reform practical teaching about the pharmaceutical management experimental course, to make an investigation and analysis of the students’ three independent learning ability status in the environment of “Know-all pharmacy V2.0” software, and to provide a new theoretical basis for the pharmaceutical management experimental course teaching. The results show that the “three independent learning” method is obviously more effective and superior than the traditional teaching in Three Independent Learning Method, Pharmaceutical Management, Experimental Course Teaching, Countermeasures https://www.ijper.org/article/50/1/90-102 2026-04-16T10:03:14.942666+00:00 Identification of Risk Factors for Diabetes Type 2 and Components of Pharmacists’ Interventions in Community Pharmacy Setting: A Serbian Pilot Study 2016-07-16 10.5530/ijper.50.1.12 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-90.pdf Prevention of Type 2 diabetes (T2D) is clinical service useful to implement on community pharmacy settings (CP). The objectives of study were: to determine the risk factors for T2D in adults visiting a community pharmacy; to determine and describe component of pharmacists’ interventions (PI) focusing on feasibility of complex intervention (CI). A cross-sectional study design and conducted (January 2010 to June 2011) on 20 CP in Serbia. Adult population was enrolled (304 patients).The pharmacist Prevention, Type 2 Diabetes Mellitus, Pharmacists’ Intervention, Complex intervention, Community, Pharmacy https://www.ijper.org/article/50/1/109-115 2026-04-16T10:03:26.504452+00:00 Chitooligosaccharides Attenuate Lipopolysaccharide induced Inflammation and Apoptosis of Intestinal Epithelial Cells: Possible Involvement of TLR4/NF-κB Pathway 2016-07-16 10.5530/ijper.50.1.14 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-1-109.pdf Marine-derived chitooligosaccharides (CHOS) are a new class of anti-inflammatory natural products characterized by its nontoxity, low-cost and small-molecule. But whether CHOS exert a protective action against inflammatory bowel diseases (IBDs) is not yet fully understood. This paper studied the effect of CHOS on the inflammation and apoptosis of intestinal epithelial cells (IECs) using lipopolysaccharides (LPS)-stimulated Caco-2 cells as an in vitro model of IBD. Caco-2 cells were pre-incubated Chitooligosaccharides, Inflammatory bowel diseases, Lipopolysaccharides, Intestinal epithelial cells https://www.ijper.org/formulation-and-evaluation-of-gastroretentive-floating-microspheres-of-lafutidin 2026-04-17T04:46:21.270256+00:00 Formulation and Evaluation of Gastroretentive Floating Microspheres of Lafutidine 2016-06-28 10.5530/ijper.50.2.21 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-76.pdf Background: Gastroretentive floating microsphere containing Lafutidine, a second generation histamine H2–receptor antagonist were prepared by ionotropic gelation technique by using sodium alginate, HPMC K4M, ethyl cellulose as polymers, sodium bicarbonate as gas generating agent and calcium chloride as cross linking agent. Objective: To formulate a system to remain in the stomach for prolonged and predictable period in order to enhance the drug bioavailability. Method: They were evaluated for mi Lafutidine, HPMC K4M, Sodium alginate, Ethylcellulose, Floating, Microsphere https://www.ijper.org/natural-gellan-gum-phytagel-based-novel-hydrogel-beads-of-rifampicin-for-oral-de 2026-04-17T05:00:49.077737+00:00 Natural Gellan Gum (Phytagel®) Based Novel Hydrogel Beads of Rifampicin for Oral Delivery with Improved Functionality 2016-06-28 10.5530/ijper.50.2.32 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-159.pdf Background: Despite exhaustive global efforts, tuberculosis (TB) continues to higher rates of infection and drugresistance rates are also raising to alarming levels. Sustained release dosage forms are gaining higher acceptance over conventional dosage forms in the treatment of several chronic conditions including TB. The aim of this study was to investigate whether the novel particulate system improved the drug release profile of rifampicin when formulated with natural polymer based hydrogel bea Microbeads, Hydrogels, Tuber culosis, Ionotropic gelation, Chitosan https://www.ijper.org/thermosensitive-in-situ-gel-for-ocular-delivery-of-lomefloxacin 2026-04-17T04:50:04.68513+00:00 Thermosensitive In situ Gel for Ocular Delivery of Lomefloxacin 2016-06-28 10.5530/ijper.50.2.24 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-96.pdf The temperature sensitive in situ gel formulations, undergo phase transition from liquid to semisolid gel upon exposure to physiological eye temperature. These are free-flowing liquid at room temperature and easy to administer into the eye as drops. They undergo in situ phase transition to form a strong gel that is capable of withstanding shear forces in the culde-sac and of sustaining drug release at physiological conditions. Lomefloxacin hydrochloride is a broad spectrum, second generation flu Lomefloxacin, Pluronic F127, Thermoreversible sol gel, Cold technique, Phase transition, Shear, thinning systems https://www.ijper.org/development-of-novel-lipid-nanoparticles-for-oral-bioavailability-enhancement-of 2026-04-17T05:01:32.445872+00:00 Development of Novel lipid Nanoparticles for oral Bioavailability Enhancement of Irinotecan: In-vitro and In-vivo Investigations 2016-06-28 10.5530/ijper.50.2.33 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-169.pdf Background: Irinotecan is indicated as a first line treatment for metastatic colorectal cancer. However, chemotherapy with irinotecan is restricted to i.v. route owing to poor and erratic oral bioavailability due to its excessive intestinal efflux by P-glycoprotein. Objective: Aim of the present study is to improve the oral pharmacokinetic profile of irinotecan (IRT) by merging the attributes of nano-particulate system and P-glycoprotein (P-gp) modulation activity of excipients. Methods: Gelucir Gelucire 44/14, Lipid nanocarrier, Intestinal gut sac method, Pharmacokinetic study https://www.ijper.org/characterization-partial-purification-of-alkaline-protease-from-intestinal-waste 2026-04-16T10:58:00.077218+00:00 Characterization, Partial Purification of Alkaline Protease from Intestinal Waste of Scomberomorus Guttatus and Production of Laundry Detergent with Alkaline Protease Additive 2016-06-28 10.5530/ijper.50.2.19 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-59.pdf Background: Fish industry wastes are an important environmental contamination source. A way of minimizing the environmental problems generated by the high amount of fish wastes is its transformation to a commercially useful ingredient. Alkaline proteases, one of the most important industrial enzymes are extracted especially from the Intestine of fish. They are widely used in laundry detergents for the degradation of protein. Methods: The protease extracted from Seer fish (Scomberomorus guttatus) Protease, Seer Fish, Scomberomorus guttatus, Alkaline proteases, Zymogram, commercial detergents, Laundry detergent https://www.ijper.org/colon-targeting-guar-gum-microspheres-of-5-aminosalicylic-acid-evaluation-of-var 2026-04-17T04:52:29.205952+00:00 Colon Targeting Guar Gum Microspheres of 5-Aminosalicylic Acid: Evaluation of Various Process Variables, Characterization and In-vitro Drug Release 2016-06-28 10.5530/ijper.50.2.25 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-106.pdf Background and objectives: 5-Amino salicylic acid (5-ASA), a drug of choice for the treatment of crohn’s disease and ulcerative colitis, rapidly absorbs from the small intestine and there is little localization of 5-ASA in the colon. Thus, we have developed a colon-specific delivery cargo of 5-ASA to release the maximum drug in colon. Methods and Results: 5-ASA loaded guar gum microspheres were prepared by emulsion polymerization technique and optimized for particle size, entrapment efficiency a 5-ASA, 5-aminosalicylic acids, Colon, Guar gum, In vitro drug release https://www.ijper.org/evaluation-on-teaching-mentoring-program-based-on-reflective-pedagogy-paradigm 2026-04-17T05:02:19.773159+00:00 Evaluation on Teaching Mentoring Program Based on Reflective Pedagogy Paradigm 2016-06-28 10.5530/ijper.50.2.34 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-180.pdf Background: The aim of Jesuit education in brief is to produce graduates who have the intellectual and emotional capacity to be humanist, open to change, and full of love to serve others. To form graduates with such qualities, the Reflective Pedagogy Paradigm (RPP) is a critical part of the learning process. In order to teach using the RPP, an academic program was needed and developed in Jesuit institutions. For this reason, a study of an academic mentoring program was conducted in the Faculty o Ignatian Spirituality, Reflective Pedagogy Paradigm, Academic mentoring program, Teaching, preparation, Lecturer development https://www.ijper.org/in-vitro-antioxidant-and-cytotoxic-activities-of-new-herbal-ointments 2026-04-16T10:46:57.16466+00:00 In vitro Antioxidant and Cytotoxic Activities of New Herbal Ointments 2016-06-28 10.5530/ijper.50.2.12 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-1.pdf Objective: The present study was aimed to investigate the possible effect of newer poly herbal ointment formulations against skin cancers. Materials and Methods: The newer polyherbal ointment formulations (PHF-I, PHF-II and PHF-III) containing varying proportions of Zingiber officinale (rhizome), Curcuma longa (rhizome), Aloe barbadensis (leaf), Citrus aurantium (peels), Emblica officinalis (fruit) extracts and castor oil (Ricinus communis) were evaluated for their in vitro antioxidant activity Antioxidant, Cytotoxicity, Polyherbal Formulation (PHF), Free Radicals, Absorbance, Ointments https://www.ijper.org/capillary-electrophoresis-mekc-assay-method-for-simultaneous-determination-of-ol 2026-04-17T05:03:05.174486+00:00 Capillary Electrophoresis: MEKC assay method for simultaneous determination of olmesartan medoxomil, amlodipine besylate and hydrochlorothiazide in tablets 2016-06-28 10.5530/ijper.50.2.35 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-188.pdf Objectives: A simple, fast, accurate and precise micellar electrokinetic chromatographic (MEKC) method was developed and validated for the simultaneous quantification of olmesartan medoxomil (OLM), amlodipine besylate (AMB) and hydrochlorothiazide (HCT) in tablets. Methodology: The analytes were separated and quantified on untreated fused silica capillary with the help of background electrolyte comprising of 40 mM phosphate buffer, 20 mM sodium dodecyl sulphate (pH 6.0) and acetonitrile (90%:10% Amlodipine, Hydrochlorothiazide, MEKC, Olmesartan, Simultaneous determination https://www.ijper.org/dexmedetomidine-application-in-pediatrics-paper-review 2026-04-17T04:59:25.228864+00:00 Dexmedetomidine, Application in Pediatrics: Paper Review 2016-06-28 10.5530/ijper.50.2.31 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-153.pdf Introduction: Dexmedetomidine is a drug with sedative, hypnotic, and analgesic properties. Its use in adult sedation was approved in 1999. In children, although the use has not been approved, its application by paediatricians is common. The drug offers many advantages in sedative procedures of paediatric patients. First, the half-life is relatively short. Second, it has little or no effect on respiratory management, and lastly, it is well tolerated by intensive care unit patients found with mech Dexmedetomidine, Pharmacokinetic/pharmacodynamic, Paediatric patients, Adverse reaction, Applications https://www.ijper.org/a-comparative-docking-studies-of-dichloroacetate-analogues-on-four-isozymes-of-p 2026-04-16T10:52:38.894553+00:00 A Comparative Docking Studies of Dichloroacetate Analogues on Four Isozymes of Pyruvate Dehydrogenase Kinase in Humans 2016-06-28 10.5530/ijper.50.2.15 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-32.pdf Introduction: The four Pyruvate dehydrogenase kinases (PDKs) that regulate the mammalian Pyruvate dehydrogenase complex (PDC) are a novel class of kinases that are expressed in most tissues. PDK is a novel therapeutic target in oncology. Recent studies show that various oncogenes or transcription factors essential for cancer development, such as loss of p53 or activation of HIF1α can induce PDK expression and therefor inhibit PDH and glucose oxidation. Dichloroacetate (DCA) is a pyruvate mimetic DCA analogues, Molecular docking studies, PDK isozymes, Pyruvate dehydrogenase kinase, Statistical, analysis https://www.ijper.org/solubility-enhancement-of-satranidazole-using-self-emulsified-drug-delivery-syst 2026-04-16T10:58:40.053008+00:00 Solubility Enhancement of Satranidazole Using Self Emulsified Drug Delivery Systems 2016-06-28 10.5530/ijper.50.2.20 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-68.pdf Background: Satranidazole is an antiprotozoal and antibacterial drug which falls under class II drug as per biopharmaceutical classification systems having poor aqueous solubility. Aim: Therefore, present study was aimed at solubility enhancement of Satranidazole using self emulsified drug delivery system (SEDDS). Methods: SEDDS was prepared using Oleic acid as oil, Tween 20 and PEG400 as Surfactant and Co-surfactant respectively. For preparation of stable SEDDS, micro emulsion region was identi Satranidazole, Surfactants, Lipid vehicles, Pseudo ternary phase diagrams, SEDDS https://www.ijper.org/effect-of-memantine-and-hespiridine-on-monosodium-glutamate-induced-excitotoxici 2026-04-16T10:56:35.135277+00:00 Effect of Memantine and Hespiridine on Monosodium Glutamate Induced Excitotoxicity in Rats 2016-06-28 10.5530/ijper.50.2.18 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-52.pdf Background: Glutamate mediated excitotoxicity is proved to be involved in neurodegenerative diseases like ischemia, trauma, diabetic retinopathy, glaucoma, seizures. Development of specific glutamate antagonists favors a better treatment opportunity of these neurodegenerative diseases. Hesperidin, a proven antioxidant and memantine a known NMDA antagonist were selected and evaluated for their neuroprotective property against monosodium glutamate induced excitotoxicity model both in vitro and in Glutamate, Excitotoxicity, Ajinomoto, Hesperidin, Memantine https://www.ijper.org/development-and-in-vitro-evaluation-of-theophylline-loaded-matrix-tablets-prepar 2026-04-16T10:55:15.574151+00:00 Development and in vitro Evaluation of Theophylline Loaded Matrix Tablets Prepared with Direct Compression 2016-06-28 10.5530/ijper.50.2.17 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-45.pdf The objectives of the present study are to develop novel sustained release matrix tablets of theophylline and to evaluate release properties and kinetic behaviour of these tablets. The formulations have been prepared in order to improve their dissolution properties in terms of providing better oral absorption of theophylline. Therefore, the effects of the components’ nature and their proportion in the release rate were investigated. Theophylline loaded tablets were prepared with direct compressi Theophylline, Drug release, Kinetic evaluation, Tablet, Direct compression https://www.ijper.org/in-vitro-anti-oxidant-assay-hplc-profiling-of-polyphenolic-compounds-aas-and-fti 2026-04-16T10:48:46.243871+00:00 In vitro Anti-oxidant Assay, HPLC Profiling of Polyphenolic Compounds, AAS and FTIR Spectrum of Malaysian Origin Solanum torvum Fruit 2016-06-28 10.5530/ijper.50.2.13 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-11.pdf Objective: Solanum torvum swartz, a Solanaceae family plant is used by traditional systems of medicine. The aim of this study is to determine the phytochemical content and antioxidant potential of the fruits of Solanum torvum of Malaysian origin. Method: A preliminary phytochemical screening was carried out for the analysis of important phytochemicals present in Solanum torvum Fruit. Anti-oxidant potential of S. torvum Fruit was evaluated by various scavenging models including DPPH, FRAP and HPL Polyphenolic compounds, Antioxidant property, HPLC, AAS, FTIR https://www.ijper.org/occurrence-of-the-triple-whammy-in-an-outpatient-clinic-of-a-tertiary-hospital 2026-04-16T10:53:40.95062+00:00 Occurrence of the Triple Whammy in an Outpatient Clinic of a Tertiary Hospital 2016-06-28 10.5530/ijper.50.2.16 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-39.pdf Background: The combination of Non-steroidal Anti-inflammatory Drugs (NSAIDs), Angiotensin-Converting Enzyme Inhibitors (ACEIs) and diuretics, among patients is common. The combination of these drugs can lead to renal disease and kidney failure over a long term use. Objectives: To identify the occurrence of the concomitant prescriptionof NSAIDs, ACEIsand diuretics, usually referred to as triple whammy, received by out-patients at a Malaysian tertiary hospital. It also aimed to identify the occur Non-steroidal anti-inflammatory drugs, Angiotensin-converting enzyme inhibitors, Diuretics, Kidney, failure, Renal impairment https://www.ijper.org/optimization-of-transmucosal-buccal-delivery-of-losartan-potassium-using-factori 2026-04-17T04:55:54.998068+00:00 Optimization of Transmucosal Buccal Delivery of Losartan Potassium using Factorial Design 2016-06-28 10.5530/ijper.50.2.28 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-132.pdf Objective: Buccal delivery is considered to be an important alternative to the peroral route for the systemic administration of drugs. Losartan potassium is an angiotensin II receptor antagonist with an oral bioavailability of only 33% due to extensive first pass metabolism. Methodology: Mucoadhesive buccal films of losartan potassium were prepared using solvent casting method with hydroxyl propyl methyl cellulose HPMC K100M and xanthan gum as retardant polymers xanthan gum and plasticizer as pr Losartan potassium, HPMC K100M, Xanthan gum, Buccal mucosa, Mucoadhesive, Permeation https://www.ijper.org/inhalable-cationic-niosomes-of-curcumin-enhanced-drug-delivery-and-apoptosis-in 2026-04-16T10:51:45.257255+00:00 Inhalable Cationic Niosomes of Curcumin Enhanced Drug Delivery and Apoptosis in Lung Cancer Cells 2016-06-28 10.5530/ijper.50.2.14 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-21.pdf Background: Curcumin induces apoptosis in non-small cell lung cancer cells. Hence, inhalable cationic niosomes of curcumin were developed to surmount the poor physicochemical and biopharmaceutical limitations for effective drug delivery in lung cancer cells. Methods: Curcumin loaded freeze-dried cationic small unilamellar niosomes (Cur-C-SUNS) were prepared using reverse phase evaporation method and characterized in vitro using spectral, analytical and biological techniques. Results: The nanoves Curcumin, Inhalation, Cationic niosomes, Lung cancer cells, Cytotoxicity, Apoptosis, Cellular uptake https://www.ijper.org/in-silico-identification-of-novel-ligand-molecules-for-rabies-nucleoprotein-usin 2026-04-17T04:56:47.183236+00:00 In Silico Identification of Novel Ligand Molecules for Rabies Nucleoprotein using Structure-Based Method 2016-06-28 10.5530/ijper.50.2.29 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-140.pdf Background: Rabies is a life-threatening condition which much privileged in Asia and Africa causes high mortality annually. It has to be treated before showing of any clinical signs. Presently vaccination is the lone accessible medication. Several research are taking place around worldwide for production of epitope based and DNA vaccines. Rabies Nucleoprotein plays a decisive role in transcription and replication process in rabies virus. In this study 2 ligand molecules were identified to preven Nucleoprotein, Homology modeling, Energy minimization and Simulation, Structure-based, pharma cophore, Molecular docking https://www.ijper.org/immunomodulatory-effect-of-decalepis-hamiltonii-wight-and-arn-roots-extract-on-r 2026-04-17T04:58:30.951761+00:00 Immunomodulatory Effect of Decalepis hamiltonii Wight and Arn Roots Extract on Rodents 2016-06-28 10.5530/ijper.50.2.30 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-146.pdf Background: Decalepis hamiltonii Wight and Arn (Asclepiadaceae) commonly known as ‘nannari’ is an Indian medicinal plant which is having ethno-medicinal uses as antioxidant, tonic and blood purifier. It is used in many Ayurvedic preparations like Drakshadi churna (general vitalizer), Shatavari rasayana (adaptogenic), and Yeshtimadhu taila (mild analgesic, rheumatism). Aim of the present study is to evaluate the immunomodulatory activity of D. hamiltoni roots aqueous extract in rodents. Methods: Nannari, Cyclophosphamide, Hemagglutination antibody titer, Neutrophil adhesion test, Carbon, clearance assay https://www.ijper.org/higher-biofilm-formation-by-multi-drug-resistant-k-pneumoniae-and-k-rhinosclerom 2026-04-17T04:47:41.787661+00:00 Higher Biofilm Formation by Multi-Drug Resistant K. pneumoniae and K. rhinoscleromatis Strains and Effects of Lemon and Ginger Essential Oils on Biofilm Formation 2016-06-28 10.5530/ijper.50.2.22 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-82.pdf Background: Klebsiella strains are opportunistic pathogens forming biofilms on many surfaces. Nowadays some resistance traits’ acquirements via gene transfer mechanisms in biofilm environments cause an urgency to discover new substances targeting biofilm inhibition. Objective: The focus of this study is to examine different K. pneumoniae and K. rhinoscleromatis strains’ clinical information and antibiotic resistance results according to their biofilm formation levels and to determine lemon and g Anti-Biofilm, Biofilm Formation, Ginger Essential Oil, Klebsiella pneumoniae, Klebsiella rhinoscleromatis, Lemon Essentil Oil https://www.ijper.org/development-of-extended-release-matrix-tablets-of-felodipine-through-solid-dispe 2026-04-17T04:48:24.777898+00:00 Development of Extended Release Matrix Tablets of Felodipine Through Solid Dispersions for Better Drug Release Profile by a 32 Factorial Design 2016-06-28 10.5530/ijper.50.2.23 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-89.pdf Felodipine extended release matrix tablets with slow initial release and long action are suitable for once daily administration and might be good substitutes for immediate acting calcium channel blockers to minimize the risk of myocardial infarction. The aim of the present study are to prepare felodipine extended release matrix tablets through forming solid dispersions of the drug followed by wet granulation technique and also to study the influence of polymers on the release rate of the drug. T Felodipine, Solid dispersion, Matrix tablet, Design of Experiments, Analysis of Variance https://www.ijper.org/design-and-in-vivo-evaluation-of-buccoadhesive-hydrophilic-polymer-matrix-films 2026-04-17T04:53:40.13082+00:00 Design and In vivo Evaluation of Buccoadhesive Hydrophilic Polymer Matrix Films of Losartan Potassium 2016-06-28 10.5530/ijper.50.2.26 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-115.pdf Introduction: The buccal mucosal route can be considered as an alternative to oral administration for the purpose of improving bioavailability and therapeutic efficacy of drugs such as losartan potassium that suffers from significant first pass metabolism. Objectives: The objective of this investigation was to formulate mucoadhesive buccal films of losartan potassium, an antihypertensive and evaluate them for in vitro drug release and in vivo buccal absorption. Methods: Film formulations were pr Buccal administration, Carbopol, Losartan, Mucoadhesive, Rabbits, Sodium carboxymethyl cellulose https://www.ijper.org/effects-of-salvia-virgata-jacq-on-jurkat-clone-e6 2026-04-17T04:55:18.959401+00:00 Effects of Salvia virgata Jacq. on Jurkat Clone-E6 2016-06-28 10.5530/ijper.50.2.27 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2s-125.pdf Objectives: The genus Salvia is one of the most widespread members of the Lamiaceae family and S.virgata Jacq. decoction is traditionally used for leukemia in Turkey. In this study, water extract and methanol extract of S. virgata were investigated for their antiproliferative effects on Jurkat (Clone E6-1) leukemia cell lines and also GSH-Px, SOD and MDA levels were evaluated as oxidative stress parameters. Methods: The cell proliferation was studied by using Alamar Blue assay and the cell viabi Salvia virgata Jacq, Jurkat cell line, Rosmarinic acid, SOD, GSH-Px, TBARS https://www.ijper.org/microneedle-assisted-transdermal-delivery-of-levodopa 2026-04-16T10:30:03.346951+00:00 Microneedle Assisted Transdermal Delivery of Levodopa 2016-01-12 10.5530/ijper.50.2.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2-287.pdf Objectives: The present study was designed to investigate the role of microneedle arrays (0.6 and 1.2 mm lengths) in enhancing the in vitro permeation of levodopa (LD) across pig ear skin. Experimental: In vitro skin permeation studies were carried out using Franz diffusion cells for a period of 24 h. A previously developed and validated RP-HPLC-PDA method was used to analyze the samples. Histological examination of skin samples treated with microneedles was carried out to confirm the penetratio Levodopa, Micro-needle arrays, Parkinson’s disease, Permeation enhancement, Transdermal delivery https://www.ijper.org/medical-tourism-ethics-risks-and-benefits 2026-04-16T10:22:49.013817+00:00 Medical Tourism: Ethics, Risks and Benefits 2016-01-12 10.5530/ijper.50.2.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2-261.pdf Background: Despite of the global increase of medical tourism, there is no review done to examine the motivation leads to the practice of medical tourism, opportunities and risks with the practice of medical tourism and the ethical issue of medical tourism. Objectives: This review aims to highlight the issues associated with medical tourism and its facilitators and barriers by evaluating literature of the development and types of medical tourism in these countries. Methodology: We reviewed the r Medical tourism, Hospital care, Health care quality, Access and evaluation, Cross-border medical, tourism, Push and pull factors https://www.ijper.org/soluplus-based-polymeric-micelles-and-mixed-micelles-of-lornoxicam-design-charac 2026-04-16T10:28:25.68951+00:00 Soluplus Based Polymeric Micelles and Mixed Micelles of Lornoxicam: Design, Characterization and In vivo Efficacy Studies in Rats 2016-01-12 10.5530/ijper.50.2.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2-277.pdf Aim: To investigate potential of polymer Soluplus (SP), to form micellar/mixed micellar systems and its ability to improve solubility and consequently therapeutic efficacy of model BCS Class-II drug Lornoxicam (LNX). Methods: Soluplus based micellar systems were prepared using thin film hydration method. CMC (critical micelle concentration) was determined using two methods, namely, Iodine UV spectroscopy and Pyrene fluorescence spectroscopy. Micellar systems were characterized for their particle Polymeric micelles, Lornoxicam, Soluplus, Iodine, CMC, Mixed micelles https://www.ijper.org/the-plackett-burman-model-an-improved-alternative-to-identify-the-significant-fa 2026-04-16T10:38:40.945495+00:00 The Plackett-Burman model-An Improved Alternative to Identify the Significant Factors Implied in the Preparation of Tramadol Hydrochloride Microsphere 2016-01-12 10.5530/ijper.50.2.10 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2-295.pdf Background and Purpose: According to Process Analytical Technology perspective, drug product quality should be ensured by manufacturing process design. Initial step of the process analysis is investigation of critical process parameters (CPPs). Quality is considered to be the major tool in pharmaceutical industry and failures in the quality of upcoming new chemical entities have been seen in the recent years due to complications in the formulation process. This paper describes the use of Design Microspheres, Plackett Burman design, Tramadol Hydrochloride (TH) https://www.ijper.org/encapsulation-efficiency-and-release-of-green-tea-polyphenols-from-poly-lactic-a 2026-04-16T10:40:53.64585+00:00 Encapsulation Efficiency and Release of Green Tea Polyphenols from Poly (Lactic Acid)-Poly (Ethylene Glycol) Nanoparticles are Controlled by the ratio of Poly (Lactic Acid)/Poly (Ethylene Glycol) 2016-01-12 10.5530/ijper.50.2.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2-301.pdf Introduction: Despite several health benefits of green tea polyphenols (GTP), its use as a therapeutic agent has been constrained by instability, biotransformation and poor bioavailability. Objective: In our study, GTP was encapsulated in nanoparticles prepared from different ratios of poly (lactic acid) (PLA)/poly (ethylene glycol) (PEG). Methods: GTP loaded nanoparticles were synthesized and characterized. In vitro drug GTP release was carried out followed by determining drug release kinetics Green tea polyphenols, Fickian release, Poly (lactic acid), Poly (ethylene glycol), Release kinetics, Sustained release https://www.ijper.org/comparison-of-validity-of-two-systems-of-candidates-admission-for-pharmaceutical 2026-04-16T10:10:59.393881+00:00 Comparison of Validity of two Systems of Candidates’ Admission for Pharmaceutical Studies: a 15-year Retrospective Study 2016-01-12 10.5530/ijper.50.2.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2-225.pdf Background: Comparing predictive validity of admission criteria for the MsPharm (Master of Sciences of Pharmacy) studies in the period prior and following the reform of the university admission system in Poland illustrated on the example of data obtained from the Faculty of Pharmacy at the Medical University of Warsaw (MUW). Methods: Admission data was correlated with the learning outcomes of students who undertook the MA studies at the pharmaceutical department between the years 2000/01-2009/10 Predictive validity, Student performance, Educational measurement, School admission criteria, Pharmacy education https://www.ijper.org/preparation-of-ibuprofen-emulsions-with-rapeseed-phospholipids-and-vegetable-oil 2026-04-16T10:25:26.212787+00:00 Preparation of Ibuprofen Emulsions with Rapeseed Phospholipids and Vegetable Oils 2016-01-12 10.5530/ijper.50.2.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2-271.pdf One of the formulations of the water poorly soluble drugs is the emulsion. The inner oil phase of the oil-in-water (o/w) emulsion is the carrier for the water poorly soluble drugs. In this study the soybean, rapeseed, safflower and olive oil were considered as a potential ibuprofen carriers and were investigated for dissolving of the ibuprofen. The ibuprofen dissolution test showed the different ability of the tested oils to dissolve the ibuprofen and the olive oil was selected as the proper one Ibuprofen, Emulsions, Emulsion stability, Rapeseed phospholipids, Vegetable oils. https://www.ijper.org/framework-for-action-to-implement-interprofessional-education-and-collaborative 2026-04-16T10:12:06.14766+00:00 Framework for Action to Implement Interprofessional Education and Collaborative Practice in Pharmacy and Allied health Sciences Programs in India 2016-01-12 10.5530/ijper.50.2.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2-238.pdf Background: Interprofessional education is a step towards providing higher quality patient care by producing collaborative and practice-ready health care professionals who appreciate each other’s roles in the health care settings. The objectives, learning outcomes and action plans to implement IPL in various phases is discussed in this paper. Methods: A literature review was done to write a concept paper to produce a framework for action to implement interprofessional education and collaborative Inter-professional education, Indian health care programs, Collaborative practice, Inter-professional, learning, Pharmacy https://www.ijper.org/an-innovative-teaching-strategy-for-the-outpatient-clerkship-program-at-jordan-u 2026-04-16T10:09:25.601326+00:00 An Innovative Teaching Strategy for the Outpatient Clerkship Program at Jordan University Hospital A Comprehensive Approach to Faculty Development Program 2016-01-12 10.5530/ijper.50.2.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2-215.pdf Introduction and purpose: As regular and well-structured clerkship program is needed to graduate qualified pharmacists in regard to drug knowledge and clinical skills our study was conducted in order to describe an innovative educational strategy for the outpatient clerkship and to improve the quality of clinical education in undergraduate doctor of pharmacy program. Method: Twenty one pharm D students were asked to fill an 18-questions questionnaire which designed to evaluate the course. The qu Pharmacy education, Faculty development, Curriculum development, Outpatient clerkship, Pharm D https://www.ijper.org/metacognitive-awareness-of-third-year-chinese-undergraduate-pharmacy-students-in 2026-04-16T10:14:15.455804+00:00 Metacognitive Awareness of Third-Year Chinese Undergraduate Pharmacy Students in Wuhan University of Science and Technology: Preliminary Evaluation and Implications for Training of Life-long Learners 2016-01-12 10.5530/ijper.50.2.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2-251.pdf Background: Assessing and improving metacognitive awareness in pharmay students is essential to maintain lifelong competency of pharmacists and high-quality care for their patients. Objective: This preliminary study aimed to investigate the acquisition of metacognitive awareness and self-assessment as a predictor/estimator of scores on a summative examination in 57 third-year Chinese undergraduate pharmacy students in Wuhan University of Science and Technology. Methods: The 30-item Meta-cognitio Metacognitive awareness, Pharmacy education, China, 30-item meta-cognitions questionnaire, Life, long learning, Assessment https://www.ijper.org/video-recording-feedback-in-communication-and-counselling-among-pharmacy-student 2026-04-16T10:13:21.373582+00:00 Video Recording Feedback in Communication and Counselling Among Pharmacy Students. Is it Better than Verbal Feedback? 2016-01-12 10.5530/ijper.50.2.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-50-2-246.pdf Objectives: This study was conducted to evaluate the effect of video recording feedback in comparison to verbal feedback in communication and counselling among pharmacy students in Universiti Kebangsaan Malaysia. Methods: Fourth year pharmacy students (N=45) were randomly assigned into three groups, where students received either video feedback (N=16), verbal feedback (N=16) or no feedback (control group) [N=13] after counselling session. The students’ performances of communication and counselli Communication and counselling, Video recording feedback, Verbal feedback, Pharmacy students https://www.ijper.org/article/49/1/76-81 2026-04-15T06:41:08.902977+00:00 Effect of Pongamia Bark Extract on antihyperglycemic effect of glibenclamide for possible herb-drug interaction 2015-12-27 10.5530/ijper.49.1.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-1-76.pdf Use of herbs or herbal medicines with prescription allopathic medicines may lead to beneficial or harmful herb-drug interaction, which needs a scientific substantiation. The present study was intended to determine the interaction between glibenclamide and methanolic extract of bark of Pongamia glabra Vent. (PBME), a herb with reported antidiabetic effect. The interaction was evaluated in normal and alloxan-induced diabetic rats using the parameters such as glucose tolerance test, acute and sub-a Pongamia glabra, glibenclamide, herb-drug interaction, hypoglycemic effect https://www.ijper.org/article/49/1/31-39 2026-04-15T06:40:29.809438+00:00 Empathy In Chinese Pharmacy Undergraduates: Implication for Integrating Humanities Into Professional Pharmacy Education 2015-12-27 10.5530/ijper.49.1.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-1-31.pdf At present, fostering and promoting empathy, an important humanistic quality, are believed ethical imperatives, and should be carried through the pharmacy education to facilitate the interpersonal and philosophical development of healthcare students. A cross-sectional study used the JSE-HPS (Jefferson Scale of Empathy-Health Profession Student version) to assess 263 Chinese pharmacy undergraduates from 1st to 4th year at Wuhan University of Science and Technology. Attached to the scale was a sur Empathy, Jefferson scale, pharmacy education, humanistic education, pharmacist-patient, communication https://www.ijper.org/article/49/1/18-25 2026-04-15T06:52:00.138724+00:00 Learning the Fundamentals of Traditional Chinese Medicine by Using Computer Courseware: A Preliminary Study 2015-12-27 10.5530/jper.49.1.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-1-18.pdf Context: The knowledge and terms of Traditional Chinese Medicine are abstract and difficult for students and the public to understand in the present day. Aim: This article describes the development of Traditional Chinese Medicine computer courseware on DVD and the study done for determining whether instructions designed digitally are as effective as the instructions explained in the traditional lectures for students to acquire awareness of the abstract concepts and terms of Traditional Chinese M Traditional Chinese Medicine (TCM) Computer courseware, digital learning, Traditional Chinese Medicine (TCM), Taiwanese college learners, instructional design, animated story https://www.ijper.org/article/49/1/58-65 2026-04-15T06:40:49.283391+00:00 Studies on Phytochemicals, Antioxidant, Free Radical Scavenging and Lipid Peroxidation Inhibitory effects of Trachyspermum ammi seeds 2015-12-27 10.5530/ijper.49.1.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-1-58.pdf Objective: Reactive oxygen species and free radicals generate oxidative stress in the living cells associated with number of chronic diseases. Current research is directed towards finding naturally occurring antioxidants of plant origin. Hence, this study was aimed to determine phytochemical analysis, antioxidant and free radical scavenging potential of ethanolic seed extract of Trachyspermum ammi (ESETA). Methods: A preliminary phytochemical screening was carried out for the analysis of importa Trachyspermum ammi, Phytochemicals, Reactive oxygen species, Free radicals, Antioxidant activity https://www.ijper.org/article/49/1/1-9 2026-04-15T06:39:46.82317+00:00 Assessment of reliability, sensitivity, objectivity and validity of MCQ Pharmacology Exams as a potential output variable for predictive analysis 2015-12-27 10.5530/ijper.49.1.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-1-1.pdf Aim: The study aimed to assess the reliability, sensitivity, objectivity and validity of the multiple-choice question (MCQ) Pharmacology Exams conducted between 2009-2014 at the Faculty of Pharmacy, Medical University of Warsaw (MUW), and to analyse the correlations between its results and the chosen criteria of selection of candidates for Pharmacy. Methods: A 6-year retrospective surveillance analysis using the admissions data of candidates for Pharmacy in the years 2005-2010 (N=584) and multi- Performance, Admission, Output variable, Academic Progression, Pharmacy, Students, Pharmacy Education https://www.ijper.org/article/49/1/46-57 2026-04-15T06:55:52.955823+00:00 Triple reuptake inhibitor potentially ameliorates the chronic unpredictable stress induced comorbid depression and anxiety: A Behavioural based rodent test battery evaluation 2015-12-27 10.5530/ijper.49.1.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-1-46.pdf Depression and anxiety tend to be the most prevalent conditions among the multitude of neurobehavioural disorders which cause distress in chronic stress condition. The objective of the present investigation was to examine the effect of DOV-216303 (a tripe re-uptake inhibitor) in depression-like and anxiety-like behaviour of rats following CUS. Rats were subjected to an experimental setting of CUS for 20 days. Escitalopram (10 mg/ kg and DOV-216303 (2.5, 5 and 10 mg/kg) were administered to stres DOV-216303, Comorbidity, CUS, Depression, Anxiety, Behavioural test Battery https://www.ijper.org/article/49/1/40-45 2026-04-15T06:40:35.801324+00:00 Stability of Cabazitaxel Solution after Dilution in Normal Saline and Stored in Glass 2015-12-27 10.5530/jper.49.1.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-1-40.pdf Objective: To evaluate the stability of cabazitaxel diluted in 0.9% sodium chloride (NS) and stored in glass. Methods: A reverse-phase stability-indicating liquid chromatographic method was developed and validated before the study. The commercially available product was prepared according to the manufacturer’s instructions, and further diluted in NS to obtain concentrations of 0.120 mg/mL and 0.240 mg/mL cabazitaxel and stored in glass under refrigeration and at 25ºC, all of them protected from Cabazitaxel, Jevtana, Stability, HPLC, Cytotoxic https://www.ijper.org/article/49/1/26-30 2026-04-15T06:40:16.43902+00:00 Establishment of a Reformed Chinese-English Bilingual Teaching System of Pharmacology in Tianjin University of Science and Technology, China 2015-12-27 10.5530/ijper.49.1.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-1-26.pdf With the rapid development of pharmaceutical industry and the requirement of economic globalization, the demand of international pharmaceutical professionals in China has been kept increasing. In this project, to set up a Chinese-English bilingual teaching system of pharmacology for undergraduate students majored in Pharmaceutical Engineering, a survey had been conducting to evaluate the general talents and attitudes of students and the need of the industry for 7 years in Tianjin University of S Chinese-English bilingual education, Pharmacology, Pharmaceutical Engineering, Textbook reform, China https://www.ijper.org/article/49/1/66-70 2026-04-15T06:40:56.936548+00:00 Screening of Antianxiety Activity of Abies pindrow Royle Aerial Parts 2015-12-27 10.5530/ijper.49.1.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-1-66.pdf Abies pindrow Royle (Himalayan Silver Fir; Pinaceae) has been traditionally used for the treatment for anxiety but the plant has not been systematically investigated to validate its traditional claims. Thus, it was planned to investigate antianxiety activity of various extracts and fractions of A. pindrow aerial parts using elevated plus maze model (EPM). Properly identified A. pindrow aerial parts were successively and exhaustively extracted using solvents in increasing order of polarity viz., Abies pindrow, Anxiolytic, Diazepam, Elevated plus maze https://www.ijper.org/article/49/1/10-17 2026-04-15T06:46:33.531858+00:00 Self-directed pharmacotherapy learning to fifth-year pharmacy students in Spain 2015-12-27 10.5530/ijper.49.1.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-1-10.pdf Pharmacy students have a difficulty in implementing the theoretical pharmacotherapy knowledge into practice, during their Advanced Pharmacy Practice Experiences (APPEs). The objective of this work was to evaluate the effectiveness of a teaching tool to guide students’ self-directed pharmacotherapy learning. Students checked their own knowledge about: generic name, drug class, indication, dosage, potential adverse reactions and interactions, of 10 prescription drugs per week, during six months of Advanced Pharmacy Practice Experience, Pharmaceutical Care, Pharmacotherapy, Self-directed learning, Undergraduate Pharmacy Student. https://www.ijper.org/article/49/1/71-75 2026-04-15T06:58:03.423315+00:00 Phytochemical and Antioxidant Studies of Salvadora persica L. Stem & Twig 2015-12-27 10.5530/ijper.49.1.10 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-1-71.pdf Salvadora persica L. commonly known as Miswak and have immense medicinal value as anti-microbial and in prevention of tooth decay. Present study deals with phytochemical and antioxidant evaluation of S. persica twig and stem. Chloroform and ethanolic extracts from S. persica twig and stem are screened for antioxidant activity using, DPPH free radical scavenging activity. Methanolic extract has been studied through HPTLC. In S. persica twig, IC50 of chloroform extract and ethanolic extract was fo Antioxidant activity, DPPH, Ferulic acid, Salvadora persica https://www.ijper.org/article/49/4/258-265 2026-04-13T05:55:31.650213+00:00 Problem Based Learning (PBL): A Novel and Effective Tool of Teaching and Learning 2015-05-25 10.5530/ijper.49.4.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4-258.pdf Recently a surge has been witnessed in number of new academic pharmacy institution establishing concern with quality of graduates passing out. Survey has also established the poor understanding of the health education among the students. Developed countries have formulated and successfully implemented new strategies to impart education to the current generation. Problem Based Learning (PBL) is one of the novel technique used in majority of health universities in US, UK and Asian countries. This Cognitive, Critical thinking, Facilitator, Problem Based Learning, Trigger https://www.ijper.org/article/49/4/248-257 2026-04-16T07:33:14.478414+00:00 Review of e-learning Practice at the Tertiary Education level in Malaysia 2015-05-25 10.5530/ijper.49.4.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4-248.pdf Introduction: The term e-learning can be described as the usage of electronic devices along with or without the help of internet to conduct a learning environment where it can be beneficial for the student. Nowadays e-learning is being integrated in the tertiary education to provide a better learning environment for the student. The review presents the current practice of e-learning at the tertiary education level in Malaysia. Methodology: A database search of PubMed, Science Direct, and Google blended learning, Education research, Handheld computers, Internet, Information science, Software, Online learning https://www.ijper.org/article/49/4/344-352 2026-04-13T05:55:31.650213+00:00 Ameliorating effects of Garcinia mangostana Linn pericarp extract on hepatic antioxidants in Diethyl nitrosamine (DEN) induced Hepatocellular Carcinoma (HCC) 2015-05-25 10.5530/ijper.49.4.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4-344.pdf Background: The extract of Garcinia mangostana Linn., (GM) has demonstrated antioxidant, anti-tumoral, anti-allergic, anti-inflammatory, antibacterial and antiviral activities and is widely used as a therapeutic drug in South-East Asia. Methods: The methanolic extract of GM fed orally to a set of Wistar rats in which hepatic carcinoma is induced with the help of N-diethylnitrosamine (DEN) forms the heart of this study. Four groups of 6 rats each is used for the study. Group I: Normal rat receive Antioxidants, Catalase, Diethylnitrosamine, Garcinia mangostana Linn, Hepatocellular carcinoma, Liver Marker enzymes, Lipid peroxidation, Marker enzymes, Superoxide dismutase https://www.ijper.org/article/49/4/304-319 2026-04-13T05:55:31.650213+00:00 Enhanced Tumor Targeting and Antitumor Activity of Gemcitabine Encapsulated Stealth Liposome’s 2015-05-25 10.5530/ijper.49.4.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4-304.pdf Introduction: Cancer is a term used for diseases in which abnormal cells divide without control and are able to invade other tissues. Gemcitabine is new cytotoxic drug but some of limitations while its use likes it suppress the activity of Bone marrow i.e. effect on blood forming cells, lower half life-7-18 min.unable to deliver by oral & other route. Higher dose-1000-1250 mg/m2 require against malignancies. Effective against various solid tumor like colon, lungs, breast etc. Several attempt was Gemcitabine, Pharmacokinetic, pH gradient, Stealths Liposome, Zeta potential https://www.ijper.org/article/49/4/320-328 2026-04-13T05:55:31.650213+00:00 Formulation and Evaluation of Novel Spray-dried Alginate Microspheres as Pulmonary Delivery Systems of Rifampicin in Rats 2015-05-25 10.5530/ijper.49.4.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4-320.pdf Background: Lung administration of anti-biotics in the dry powder form is promising for improved treatment efficiency for pulmonary infections, as it increases drug concentration at sites of infection while minimizing systemic side effects. For poorly soluble molecules like rifampicin, an anti-tubercular drug encapsulated in particulate system in presence of β-cyclodextrin may improve lung delivery. Materials and Methods: Present study was aimed to evaluate the pharmacokinetic parameters of rifa Alginate, Aerodymanic Characteristics, β-cyclodextrin, Intratracheal, instillation, Pulmonary drug delivery, Spray-dried microspheres https://www.ijper.org/article/49/4/271-280 2026-04-13T05:55:31.650213+00:00 Development of Mucoadhesive Sustained Release Matrix Tablets of Methimazole for oral Delivery 2015-05-25 10.5530/ijper.49.4.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4-271.pdf The aim of the present investigation was to develop sustained release matrix tablets containing methimazole. The different batches were manufactured by direct compression method using hydrophilic swellable carbopol and ethocel and eudragit RL100 in combination using Minipress and characterized by FTIR, DSC, in vitro mucoadhesion, in vitro swelling, erosion and in vitro drug release and stability studies. It was found that, the formulation batch MT 6 has a mucoadhesion force about 14.813 ± 0.085 Carbopol 934P, Eudragit RL100, Ethyl cellulose, Methimazole, Matrix tablet, Percent swelling, Sustain, release https://www.ijper.org/article/49/4/240-247 2026-04-13T05:55:31.650213+00:00 Chemistry Content in the Pharmacy Curriculum: Relevance to Develop Pharmacists Fit-to-work in Diverse Pharmacy Profession Sectors 2015-05-25 10.5530/ijper.49.4.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4-240.pdf Background: The high employability of pharmacy graduates across various sectors such as in the community pharmacies and hospital settings, the pharmaceutical industries and academia has lent credence to the versatility of their professional training. Therefore, the aim of this study was to gauge the perception of International Medical University (IMU) pharmacy graduates on the applicability and relevance of the chemistry knowledge and practical skills acquired from their professional education i Chemistry, Competency, Fit-to-work, Graduates, Pharmacy Curriculum, Pharmacy Profession https://www.ijper.org/article/49/4/272-281 2026-04-13T05:55:31.650213+00:00 Role of libraries in Pharmacy Education and Perceptions of library Professional’s about their job 2015-05-25 10.5530/ijper.49.4.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4-272.pdf Introduction: In pharmacy education, library use do appear independent contributions to desirable outcomes of the institution. Librarians’ role is also important to make students information literate. Objective: This objective of this study to know about the role of libraries and library professional’s experience in pharmacy colleges. Materials and Methods: The data represent responses from 44 library professionals’ during the period 2013-2014 to the questionnaire. To explore role of libraries i Collections and facilities in library, Database, Drug information source, Library, professionals, Pharmacy education, Role of Library https://www.ijper.org/article/49/4/292-300 2026-04-13T05:55:31.650213+00:00 Studies on Development of Controlled Release Matrix Tablets of Camptothecin-An Anticancer Drug 2015-05-25 10.5530/ijper.49.4.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4-292.pdf Objectives: The present investigation was carried out with an objective of formulating prototype controlled release (CR) matrix tablets of Camptothecin (CPT), an anti-cancer drug. Experimental: pH solubility profile studies of CPT and solubility of CPT in different surfactants were carried out. Controlled release tablets were prepared by direct compression method using hydroxyl propylmethyl cellulose (HPMC LVCR and HPMC K4M) as release retardants. The effect of different grades of microcrystalli Camptothecin, CR matrix tablets, Cyclodextrins, Dissolution studies, Solubility studies https://www.ijper.org/article/49/4/281-291 2026-04-13T05:55:31.650213+00:00 Design and In vitro Evaluation of a Novel Sustained Release Double Layered Tablets of Lornoxicam by using semi synthetic polymers 2015-05-25 10.5530/ijper.49.4.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4-281.pdf The objective of the present study was to develop double layered tablets of lornoxicam, a highly potent nonsteroidal anti-inflammatory drug. Double layered tablets compris of fast release layer and a sustained release layer, anticipating the rapid drug release that starts in the stomach rapidly alleviate the symptoms and continuous in the intestine to maintain the prolonged analgesic effect. Double layered tablets are characterized by initial drug release in the stomach and comply the requiremen β–cyclodextrin, Double layered tablets, Lornoxicam, NSAID's, Sustained release https://www.ijper.org/article/49/4/266-271 2026-04-16T07:36:35.98241+00:00 Assessment of learning style preferences of pharmacy students: Findings from public university of Malaysia 2015-05-25 10.5530/ijper.49.4.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4-266.pdf Background: Student’s learning style preference is an important consideration for effective and high quality teaching and learning process. Different teaching approaches may not suit students’ preferences, hence, producing a gap between learning and delivery instructions. The aim of this study was to assess the learning style preferences among the first year pharmacy students of public sector university of Malaysia. Methods: A prospective cross sectional study was conducted during non-lecture ho Learning Styles, Malaysia, Pharmacy, Students, VAK Instrument https://www.ijper.org/article/49/4/301-308 2026-04-16T07:46:22.459138+00:00 Controlled Release of Antipyrine from Tablets Using Synthesized Copolymers as Matrices in Gastric Medium 2015-05-25 10.5530/ijper.49.4.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4-301.pdf Introduction: In order to control and modify the drug release, several types of devices were used to obtain a controlled release of the organic drug. A drug delivery system can be a matrix of polymer incorporating the active agent. New solid dosage forms (tablets) composed from the active agent (Antipyrine) and copolymers synthesized: Poly (vinyl acetate-co-methyl methacrylate) and Poly (vinyl pyrrolidone-co-methyl methacrylate) able to control drug release have been prepared and investigated in Antipirine, Drug release, Poly (vinylacetate-co-methyl methacrylate), Poly(vinylpyrrolidone-co-methylmethacrylate), Tablets https://www.ijper.org/article/49/4/282-292 2026-04-16T07:39:20.456134+00:00 Partially Purified Exopolysaccharide from Lactobacillus plantarum YML009 with Total Phenolic Content, Antioxidant and Free Radical Scavenging Efficacy 2015-05-25 10.5530/ijper.49.4.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4-282.pdf This study was aimed to partially purify the exopolysaccharide (EPS) from the culture of Lactobacillus plantarum YML009 using ethanol precipitation method with a yield of 260 mg/L. Analytical evaluationby Bradford and Phenolsulphuric methods revealed the presence of 2.2% and 68.1% total protein and total sugar contents in partially purified EPS, respectively. Further, to confirm the biological potential, the EPS was evaluated for its antioxidant activity in various scavenging models including DP Antioxidant, Exopolysaccharide, Free radical scavenger, Lactobacillus plantarum YML009, Total, phenolic content https://www.ijper.org/studies-on-development-of-controlled-release-matrix-tablets-of-camptothecin-an-a 2026-04-16T07:44:33.342171+00:00 Effect of Sodium alginate in Combination With HPMC K 100 M in Extending the Release of Metoprolol Succinate from its Gastro-Retentive Floating Tablets 2015-05-25 10.5530/ijper.49.4.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4-293.pdf Aim of work: The aim of present study was to convert Metoprolol Succinate (MS) into Gastro Retentive Floating Tablet (GRFT) and simultaneously to determine the effect of Sodium alginate (SA) in combination with HPMC K 100M in extending the release of MS. Method: The drug- excipients compatibility studies of MS and the polymers were carried by FTIR studies. The effervescent GRFT of MS was prepared by non aqueous wet granulation. All Formulations were evaluated for pre-compression, postcompression Gastro retentive floating tablets (GRFT), HPMC K100M, In vitro buoyancy, studies, Metoprolol Succinate (MS), Sodium alginate https://www.ijper.org/article/49/4/353-361 2026-04-13T05:55:31.650213+00:00 Quantification of Flavonoids and Nucleoside by UPLC-MS in Indian Cordyceps sinensis and its Invitro Cultures 2015-05-25 10.5530/ijper.49.4.12 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4-353.pdf Background: Cordyceps sinensis, a comestible mushroom growing in Himalayan regions, is extensively familar in traditional system of medicine. The paper presents the results of quantification of some of the flavonoids and nucleosides (kaempferol, isorhamnetin and cordycepin) in the Indian variety of Cordyceps sinensis. Since, the plant is known for its high therapeutic potential and not easily available, hence it was also tissue cultured in the laboratory as an alternative source of medicine. Met Cordycepin, Cordyceps sinensis, Isorhamnetin, Kaempferol, UPLC-MS/MS https://www.ijper.org/article/49/4s/s68-s74 2026-04-13T05:55:30.830061+00:00 Effect of the Ethanolic Extract of Scoparia dulcis in Cisplatin induced Nephrotoxicity in wistar rats 2015-05-15 10.5530/ijper.49.4s.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4s-68.pdf Objective: To evaluate the nephroprotective potential of ethanolic extract of aerial parts of plant Scoparia dulcis against cisplatin induced nephrotoxicity in Wistar rats. Materials and Methods: Nephrotoxicity was induced by a single intra-peritoneal administration of Cisplatin (6 mg/kg) in wistar rats. Nephroprotective potential of plant was tested at two different doses in curative regimen and for a single dose of 400 mg/kg in prophylactic control. Nephrotoxicity was characterised by induced Nephrotoxicity, Scoparia dulcis, Cisplatin, lipid Peroxidation, anti-oxidant https://www.ijper.org/article/49/4s/s75-s81 2026-04-13T05:55:30.830061+00:00 Binary Mixtures of Morphine and Furosemide: Compatibility and Stability at Different Concentrations 2015-05-15 10.5530/ijper.49.4s.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4s-75.pdf Objectives: In order to avoid separate injections, admixtures of drugs are frequently used in palliative care settings. There are different factors that can influence the compatibility and stability of the mixture: drug type, concentration, solvent, container, temperature and light. There are some mixtures of drugs with proven stability, but there is lack of evidence about the stability and compatibility of the combination of morphine and furosemide. The purpose is to evaluate the compatibility Furosemide, HPLC, Mixtures, Morphine, Stability https://www.ijper.org/article/49/4s/s12-s20 2026-04-13T05:55:30.830061+00:00 Molluscicidal and larvicidal activities of Capparis spinosa aerial parts against Galba truncatula intermediate host of Fasciola hepatica 2015-05-15 10.5530/ijper.49.4s.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4s-12.pdf Objective: Fascioliasis caused by Fasciola hepatica L. (Fasciolidae), a digenetic trematode, is a parasitic disease infecting many people worldwide. The present study was carried out to evaluate the molluscicidal and larvicidal activities of Capparis spinosa L. (Capparaceae) aerial parts against Galba truncatula Müll. (Lymnaeidae) and Fasciola hepatica larval stages contaminating this snail in Tunisia. Accordingly, ethyl acetate, methanol and methanol-water were used as solvents of extraction. n Capparis spinosa, Fasciola hepatica, Galba truncatula, Larvicidal activity, Molluscicidal activity https://www.ijper.org/article/49/4s/s59-s67 2026-04-13T05:55:30.830061+00:00 Quantification of Flavonoids and Nucleoside by UPLC-MS in Indian Cordyceps sinensis and its In- vitro Cultures 2015-05-15 10.5530/ijper.49.4.12 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4s-59.pdf Background: Cordyceps sinensis, a comestible mushroom growing in Himalayan regions, is extensively familar in traditional system of medicine. The paper presents the results of quantification of some of the flavonoids and nucleosides (kaempferol, isorhamnetin and cordycepin) in the Indian variety of Cordyceps sinensis. Since, the plant is known for its high therapeutic potential and not easily available, hence it was also tissue cultured in the laboratory as an alternative source of medicine. Met Cordycepin, Cordyceps sinensis, Isorhamnetin, Kaempferol, UPLC-MS/MS https://www.ijper.org/article/49/4s/s21-s30 2026-04-13T05:55:30.830061+00:00 Development of Mucoadhesive Sustained Release Matrix Tablets of Methimazole for oral Delivery 2015-05-15 10.5530/ijper.49.4.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4s-21.pdf The aim of the present investigation was to develop sustained release matrix tablets containing methimazole. The different batches were manufactured by direct compression method using hydrophilic swellable carbopol and ethocel and eudragit RL100 in combination using Minipress and characterized by FTIR, DSC, in vitro mucoadhesion, in vitro swelling, erosion and in vitro drug release and stability studies. It was found that, the formulation batch MT 6 has a mucoadhesion force about 14.813 ± 0.085 Carbopol 934P, Eudragit RL100, Ethyl cellulose, Methimazole, Matrix tablet, Percent swelling, Sustain, release https://www.ijper.org/article/49/4s/s31-s41 2026-04-13T05:55:30.830061+00:00 Design and In vitro Evaluation of a Novel Sustained Release Double Layered Tablets of Lornoxicam by using semi synthetic polymers 2015-05-15 10.5530/ijper.49.4.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4s-31.pdf The objective of the present study was to develop double layered tablets of lornoxicam, a highly potent non- steroidal anti-inflammatory drug. Double layered tablets compris of fast release layer and a sustained release layer, anticipating the rapid drug release that starts in the stomach rapidly alleviate the symptoms and continuous in the intestine to maintain the prolonged analgesic effect. Double layered tablets are characterized by initial drug release in the stomach and comply the requirem β–cyclodextrin, Double layered tablets, Lornoxicam, NSAID's, Sustained release https://www.ijper.org/article/49/4s/s51-s58 2026-04-13T05:55:30.830061+00:00 Controlled Release of Antipyrine from Tablets Using Synthesized Copolymers as Matrices in Gastric Medium 2015-05-15 10.5530/ijper.49.4.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4s-51.pdf Introduction: In order to control and modify the drug release, several types of devices were used to obtain a controlled release of the organic drug. A drug delivery system can be a matrix of polymer incorporating the active agent. New solid dosage forms (tablets) composed from the active agent (Antipyrine) and copolymers synthesized: Poly (vinyl acetate-co-methyl methacrylate) and Poly (vinyl pyrrolidone-co-methyl methacrylate) able to control drug release have been prepared and investigated in Antipirine, Drug release, Poly (vinylacetate-co-methyl methacrylate), Poly(vinylpyrrolidone-co-methylmethacrylate), Tablets https://www.ijper.org/article/49/4s/s42-s50 2026-04-13T05:55:30.830061+00:00 Studies on Development of Controlled Release Matrix Tablets of Camptothecin-An Anticancer Drug 2015-05-15 10.5530/ijper.49.4.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4s-42.pdf Objectives: The present investigation was carried out with an objective of formulating prototype controlled release (CR) matrix tablets of Camptothecin (CPT), an anti-cancer drug. Experimental: pH solubility profile studies of CPT and solubility of CPT in different surfactants were carried out. Controlled release tablets were prepared by direct compression method using hydroxyl propylmethyl cellulose (HPMC LVCR and HPMC K4M) as release retardants. The effect of different grades of microcrystalli Camptothecin, CR matrix tablets, Cyclodextrins, Dissolution studies, Solubility studies https://www.ijper.org/article/49/4s/s1-s11 2026-04-13T05:55:30.830061+00:00 GC/MS, FTIR and NMR Studies for the Identification and Characterization of Clopidogrel Bisulfate Degradation Products 2015-05-15 10.5530/ijper.49.4.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-4s-1.pdf Clopidogrel Bisulfate is a thienopyridine derivative. The separation, identification and degradation of Clopidogrel Bisulfate under hydrolytic and oxidative stress conditions according to the International Conference on Harmonization (ICH) guideline Q1A (R2) was performed. TLC using (n-hexan:tetrahydrofuran)(1:1 v/v) as a mobile phase was used to separate the degradation products. Three compounds were isolated then analyzed using RP-HPLC which showed a purity of 99%. Mass fragmentation pathway o Clopidogrel degradation products, FTIR, GC/MS, NMR, Stress studies https://www.ijper.org/article/49/3/216-224 2026-04-15T07:33:08.322996+00:00 Conjugation of Polycarbophil: Preparation and Evaluation of Bilayered Buccoadhesive Tablet form Polycarbophil Conjugate 2015-02-09 10.5530/ijper.49.3.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-3-216.pdf The purpose of the present research envisaged was synthesize, characterize polycarbophil conjugate, to study the effect of conjugation on bioadhesion and drug release from the buccoadhesive tablet. The polycarbophil conjugate was synthesised by covalent attachment of thiol group of L-cysteine with the carboxylic acid group of polycarbophil. The synthesised conjugate was characterised by charring point determination, fourier transmission infra-red spectroscopic, differential scanning calorimetric Bioadhesion, Buccoadhesive tablets, Impermeable Cap, Polycarbophil Conjugate, Diltiazem, hydrochloride https://www.ijper.org/article/49/3/190-199 2026-04-13T05:55:33.396205+00:00 Do Fixed Dose Combinations Play an Important Role in the Management of Coexistent Type Two Diabetes Mellitus and Hypertension? 2015-02-09 10.5530/ijper.49.3.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-3-190.pdf The global burden of coexistent Type Two Diabetes Mellitus (TTDM) and hypertension is rising and it is emerging as a severe threat to world health and well being. This twin epidemic of coexistent TTDM and hypertension exposes patients to severe co-morbidities like cardiovascular diseases, lower limb amputations, diabetic nephropathy, diabetic retinopathy if not treated in time and with appropriate regimen. Guidelines established by various international organizations suggest multiple drug therap Coexistent type two diabetes mellitus and hypertension, Treatment for coexistent type two diabetes, mellitus and hypertension, Fixed dose combination https://www.ijper.org/developing-a-quality-management-tool-for-preparing-good-distribution-practice-au 2026-04-15T07:28:54.659578+00:00 Developing a quality management tool for preparing Good Distribution Practice audit of pharmaceutical contract vaccine distributor 2015-02-09 10.5530/ijper.49.3.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-3-174.pdf Outsourcing is increasingly used by the vaccine manufacturers. When the manufacturing activities are outsourced, the contract manufacturer’s Good Manufacturing Practice compliance needs to be confirmed through auditing. In the same way, when distribution is outsourced, the contract distributor’s Good Distribution Practice compliance needs to be confirmed through auditing. The objective of this study was to develop an audit preparation tool for the pharmaceutical contract vaccine distributor and Audits, Delphi method, GDP, Pharmaceutical industry, Quality management https://www.ijper.org/article/49/3/168-173 2026-04-15T07:28:04.839305+00:00 Pharmacy Education in Trinidad and Tobago 2015-02-09 10.5530/ijper.49.3.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-3-168.pdf As with many countries across the globe, professional pharmacy in Trinidad and Tobago is moving from a product orientated (dispensing medications) to patient centered practice. Such a transformation faces many challenges especially for a developing nation. To alter the roles and responsibilities of pharmacists, Trinidad and Tobago is beginning to enhance existing practice settings, first with upgrading its educational programs. The main change is the introduction of pharmaceutical care as the pr B.Sc in Pharmacy, Pharmacist, Pharmacy Education, Trinidad and Tobago, West Indies https://www.ijper.org/article/49/3/200-207 2026-04-13T05:55:33.396205+00:00 Chemometric assisted spectrophotometric methods for the simultaneous determination of Rifampicin and Piperine in bulk and capsule 2015-02-09 10.5530/ijper.49.3.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-3-200.pdf In this work a numerical method, based on the use of spectrophotometric data coupled to Partial least squares (PLS),Principal component regression (PCR) andclassical least square (CLS) multivariate calibration, is evaluated for the simultaneous determination of rifampicin and piperine in bulk and capsule dosage form. Spectra of RIFA and PIPE were recorded at concentrations within their linear ranges 20-50 μg/ml & 1.0 - 2.5 μg/ml, respectively and were used to compute a total of 25 synthetic mixt Piperine (PIPE), PCR, PLS and CLS, Rifampicin (RIFA) https://www.ijper.org/article/49/3/231-239 2026-04-15T07:39:05.675821+00:00 RAPD Based Assessment of Genetic Diversity of Adhatoda vasica Leaves from Different Sub- Continents of India 2015-02-09 10.5530/ijper.49.3.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-3-231.pdf The present work assessed the genetic divergence amongst the accessions of vasaka collected from different sub-climatic zones of India by RAPD (Randomly Amplified Polymorphic DNA) using twenty random declaimer primers (OPA 1-OPA 20) as the plant was found to enjoyed its therapeutic efficacy in Ayurvedic and traditional system of medicines. The dendrogram constructed for cluster analysis using an un-weighted pair group method with arithmetic means (UPGMA) grouped the accessions into 2 major clust RAPD, Genetic diversity, Adhatoda vasica, variation, Polymorphism, Primer https://www.ijper.org/article/49/3/208-215 2026-04-15T07:31:30.646841+00:00 Design and Development of Vancomycin Liposomes 2015-02-09 10.5530/ijper.49.3.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-3-208.pdf Vancomycin hydrochloride is water soluble and poorly absorbable glycopeptide antibiotic act by inhibition of the synthesis of peptidoglycan a major component of bacteria cell wall. It is highly effective against the Staphylococcus aureus and other Staphylococcus species microorganisms. Structurally vancomycin hydrochloride has six peptide bonds with a molecular weight of approximately 1500 Da. Liposomes, the colloidal vesicular structures due to their biphasic environment can act as carriers for Liposomes, Phospholipids Permeability Enhancement, Poly ethylene glycol, Propylene glycol, Surfactants, Vancomycin Hydrochloride https://www.ijper.org/article/49/3/225-230 2026-04-15T07:37:52.257755+00:00 Warfarin Binding to Native and Structurally-Altered Human Serum Albumins 2015-02-09 10.5530/ijper.49.3.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-3-225.pdf Background and Purpose: Interaction of a drug with the carrier protein in the circulation determines its distribution, free or bound concentration and metabolism. Structural alteration in the major transport protein, human serum albumin (HSA) under several pathological conditions may affect its drug binding ability. The objective of the present investigation was to explore the binding of warfarin to structurally-altered HSA. Methods: Effect of urea, a denaturant on the interaction of warfarin wi Drug Binding, Fluorescence Quenching, Human Serum Albumin, Urea, Warfarin https://www.ijper.org/article/49/3/183-189 2026-04-13T05:55:33.396205+00:00 Effects of educational versus peer discussion interventions on perceived competence in adolescents with medulloblastoma 2015-02-09 10.5530/ijper.49.3.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-3-183.pdf Context: Limited documentation exists on the effectiveness of education-based (EG) versus peer discussionbased (PDG) group interventions on perceived competence of adolescents suffering from medulloblastoma. Aims: This study was conducted to investigate which of these approaches offers the more beneficial outcomes to participants. Settings and Design: In a hospital in Zhenjiang, China, a total of 45 pediatric patients with standard risk or high risk medulloblastoma were randomly assigned to the Adolescents, Education intervention, Medulloblastoma, Peer discussion intervention, Perceived, competence https://www.ijper.org/article/49/2/158-167 2026-04-13T05:55:34.189107+00:00 Controlled Release Ion Sensitive Floating Oral in situ Gel of a Prokinetic Drug using Gellan Gum. 2015-01-09 10.5530/ijper.49.2.13 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-2-158.pdf There are various approaches commonly used for gastric retention, one of which is raft forming system. Floating oral in situ gel is a type of raft forming system. The present work concerns with the formulation, evaluation and optimization of floating oral in situ gel of Itopride Hydrochloride for controlled release. Gellan gum has been used as a gel forming polymer and calcium carbonate as cross linking agent and Ca2+ ion source, and HPMC K100M as release retardant. The floating oral in situ gel in situ gel, CaCO3, Gellan gum, Foating drug delivery system, Ion Sensitive, Prokinetic https://www.ijper.org/article/49/2/93-98 2026-04-15T07:03:18.82053+00:00 Scope of Mix-method studies in Pharmacy Practice Research 2015-01-09 10.5530/ijper.49.2.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-2-93.pdf Conducting pharmacy practice research is particularly challenging owing to the varied approaches and methods available. While quantitative methodology has been traditionally endorsed as the more scientific method of research, there is a growing recognition for qualitative inquiry in the field of pharmacy practice research in the past few decades. Hence, the scope of this paper is to provide an overview on how to apply mixed methodology in pharmacy practice research and to discuss some of the ben Pharmacy Practice, Mixed Methodology, Quantitative, Qualitative https://www.ijper.org/article/49/2/106-111 2026-04-13T05:55:34.189107+00:00 Pharmaceutical Waste Management in Pharmacies at the Primary Level of Health Care in Serbia - Situation Analysis 2015-01-09 10.5530/ijper.49.2.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-2-106.pdf Background: Pharmaceutical products can become a potential source of poisoning. The improper disposal of unused medicines is a growing problem throughout the world, with a manifold effect on the cost of health care, public health and the environment. The objectives of this research are the overview of current situation of pharmaceutical waste management in the pharmacy sector in the Republic of Serbia, attitudes and knowledge of pharmacists on the matter and the measures they should undertake in pharmaceutical waste, environment, unused medicines, expired medicines, pharmacy, waste, management, waste law https://www.ijper.org/article/49/2/121-125 2026-04-15T07:08:19.158035+00:00 Evaluation of the analgesic effect of Umbelliprenin and Umbelliprenin-morphine co-administration on the acute, chronic and neuropathic pain 2015-01-09 10.5530/ijper.49.2.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-2-121.pdf Background and purpose: Neuropathic Pain (NP) is a complex and chronic pain which is accompanied by nerve injury. Umbelliprenin (UMB) is a naturally occurring prenylatedcoumarin with anticancer, antioxidant, anti-inflammatory, antibacterial and antileishmanial activities. This study aimed to investigate the antinociceptive effects of UMB on acute, chronic and neuropathic pain and its combination therapy with morphine on the neuropathic pain. Methods: Albino mice weighing 20-25 g were randomly di Umbelliprenin, Neuropathic Pain, Morphine, Sciatic Nerve Ligation https://www.ijper.org/article/49/2/126-133 2026-04-13T05:55:34.189107+00:00 In silico Antiurolithiatic Screening of Aerva lanata (L) Isolated constituents 2015-01-09 10.5530/ijper.49.2.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-2-126.pdf Background: Traditionally known as Pashanabheda in India, Aerva lanata (L) belonging to the family Amaranthaceae, is widely available in Western ghats of India and used as Antiurolithiatic, astringent, diuretic, antimicrobial, antiinflammatory, hepatoprotective drug by Indian traditional system of medicines. Materials and Method: In the present study this herb is subjected to extraction with hydro alcohol followed by fractionation with different solvents of varying polarities such as dichloromet Aerva lanata (L), Pashanabheda, isolation and characterization, Antiurolithiatic agents, In silico study https://www.ijper.org/article/49/2/134-139 2026-04-13T05:55:34.189107+00:00 Critical Micelle Concentration of Surfactant Using Hadkar Factor 2015-01-09 10.5530/ijper.49.2.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-2-134.pdf Critical micelle concentration is an important characteristic property of a surfactant and various methods such as osmotic pressure, surface tension, interfacial tension, UV-Visible spectrophotometry have been reported to determine it. The drop weight method was used to determine the Hadkar factor H1 for organic liquid lighter than water and Hadkar factor H2 was used for organic liquid heavier than water. The plot of H1 or H2 vs concentration of the aqueous surfactant solution was used to determ Drop weight method, Hadkar factors, Interfacial tension, critical micelle concentration, surfactant, pipette https://www.ijper.org/article/49/2/140-145 2026-04-13T05:55:34.189107+00:00 Microspheres Embedded In Microbeads: A Novel Approach to Improve Various Controlled Release Characteristics of Highly Water Soluble Drug through Ionic Gelation Method 2015-01-09 10.5530/ijper.49.2.10 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-2-140.pdf The major hindrance behind the preparation of gellan microbeads by simple ionic gelation technique with aqueous soluble drugs is their low entrapment efficiency and sometimes its faster dissolution characteristics. This limits the employment of such a simple method for the preparation of microbeads of water-soluble drugs like stavudine. In the present study a novel attempt has been undertaken by embedding stavudine loaded Eudragit RSPO microspheres into gellan microbeads by ionotropic gelation m Gellan gum, Stavudine, Microbeads, Microsphere embedded in Microbeads, Entrapment efficiency, and Controlled release https://www.ijper.org/article/49/2/99-105 2026-04-15T07:04:23.282155+00:00 Assessing Stress among Undergraduate Pharmacy Students in University of Malaya 2015-01-09 10.5530/ijper.49.2.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-2-99.pdf Health care students, particularly pharmacy students, are believed to experience a higher level of stress as compared to their age-matched peers. This cross-sectional study determined the sources and predictors of stress among 273 undergraduate pharmacy students at a Malaysian public university using the Derogatis Stress Profile instrument. The response rate was 100%. Pearson’s correlation was used to examine the association between Grade Point Average (GPA) and stress levels. Paired and Indepen Derogatis Stress Profile, perceived stress, pharmacy undergraduates, stress levels, healthcare https://www.ijper.org/article/49/2/152-157 2026-04-15T07:21:26.789741+00:00 Effect of pioglitazone, quercetin and hydroxy citric acid on inflammatory markers in experimentally induced non alcoholic steatohepatitis (NASH). 2015-01-09 10.5530/ijper.49.2.12 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-2-152.pdf Background: Non Alcoholic Fatty Liver Disease (NAFLD) spectrum comprises of diseases ranging from simple steatosis to steatohepatitis. Non-Alcoholic Steatohepatitis (NASH), an asymptomatic disease, characterized by the fatty infiltration with inflammation is a key component of NAFLD spectrum that may proceed to the liver cirrhosis, the end stage liver disease, if not diagnosed and treated properly. Inflammatory mediators have been investigated as potential diagnostic tools to understand the path Pioglitazone, Quercetin, Hydroxy citric acid, TNF- α, myeloperoxidase, Non-, Alcoholic Fatty Liver Disease (NAFLD), Non-Alcoholic Steatohepatitis (NASH) https://www.ijper.org/article/49/2/82-87 2026-04-15T07:01:18.93216+00:00 From Synthesis and Spectral Analysis to Molecular Modeling – Multidimensional Teaching of Medicinal Chemistry: Aspirin as an Example 2015-01-09 10.5530/ijper.49.2.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-2-82.pdf Classical medicinal chemistry classes do not give satisfactory learning outcomes. Computing and communication technology have a great impact on all aspects of cognition, education and training. Thus, the field of computer-assisted science teaching is particularly active nowadays. Many authors reported that involving computers in education process makes it more interesting, develops motivation of the students and helps to keep their attention during classes. Using computers for teaching science i Aspirin, Computer-Assisted Classes, Organic Chemistry, Molecular Modeling, Spectroscopic Method https://www.ijper.org/article/49/2/146-151 2026-04-13T05:55:34.189107+00:00 Effect of compounds isolated from Filicium decipiens and Ventilago madraspatana against diabetic nephropathy in streptozotocin induced diabetic rats 2015-01-09 10.5530/ijper.49.2.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-2-146.pdf Context: Diabetes mellitus is a group of syndromes characterized by hyperglycemia, altered metabolism of lipids, carbohydrates and proteins and an increased risk of complications from vascular diseases. Filicum decipiens Wight & Arn., (Sapindaceae) and Ventilago madraspatana Gaertn., (Rhamnaceae) are traditionally used for diabetic and other different folk medical uses. Objective: The present study compares the antihperglycemic activity exerted by methanolic extracts of Filicum decipiens (400 mg Filicum decipiens, Ventilago madraspatana, antioxidant and renal markers https://www.ijper.org/article/49/2/88-92 2026-04-15T07:02:18.634758+00:00 Divulging vital research information before patent filing: Suicidal 2015-01-09 10.5530/ijper.49.2.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-2-88.pdf Researchers and academicians for various reasons find themselves in a situation of divulging more than required and being deprived of recognition and benefit that they deserved. This paper briefly looks into the various advantages associated with patents, what could be the different reasons for sharing or going in public about the vital reason information before filling a patent. This paper also points to the extent one can share the information which would not siphon off “obviousness” essential information sharing methods, objectives, patent, novelty, non-obviousness, career, research https://www.ijper.org/article/49/2/112-120 2026-04-13T05:55:34.189107+00:00 Assessment of predictive value of admission criteria of candidates for pharmaceutical studies – an empirical investigation 2015-01-09 10.5530/ijper.49.2.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-49-2-112.pdf Aim: Assessment of predictive value of results of maturity exams applied as admission criteria for pharmaceutical studies at the Medical University of Warsaw (MUW) between 2010–2012. Material and methods: Data of 390 students who began their studies and completed their first year of full-time studies at the pharmaceutical department of MUW. Admission data included: total score gained by a candidate, score concerning biology, chemistry and mathematics. Results in three subjects included in the fi Performance, Admission criteria, Output variable, academic progression, pharmacy education https://www.ijper.org/article/48/4s/s7-s17 2026-04-15T06:17:34.264738+00:00 Formulation and In-vitro Evaluation of Sublingual Tablets of Ondansetron Hydrochloride using Coprocessed Excipients 2014-12-25 10.5530/ijper.48.4s.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4s-7.pdf The formulation of sublingual tablets of Ondansetron HCl was carried out by using direct compression technique and evaluation tests were carried out as per pharmacopoeial specifications. Poor compressibility problem of Mannitol was overcome by coprocessing it with maltose and corn starch in varying ratios. The results of evaluation tests indicate that the ratio of Mannitol: Maltose: Corn starch: 19:2:1 gave better tableting performance with respect to precompression & postcompression parameters. Sublingual Tablet, Direct Compression, Co-processing of excipients, Historical Data Optimization, Ondansetron HCl https://www.ijper.org/article/48/4s/s34-s39 2026-04-15T06:21:31.22195+00:00 Development and Validation of RP-HPLC Method for the Simultaneous Estimation of Paracetamol and Flupirtine Maleate in Pharmaceutical Dosage Form 2014-12-25 10.5530/ijper.48.4s.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4s-34.pdf Objective: To develop and validate a simple, efficient and reproducible RP-HPLC method for the simultaneous determination of paracetamol and flupirtine maleate in bulk and in pharmaceutical formulations. Materials and Method: The chromatographic analysis was performed on a Thermo BDS hypersil C18 (250 x 4.6 mm i.d, 5μ) column in isocratic mode using water: methanol(pH was adjusted to 3.35± 0.02 with ortho-phosphoric acid) in the ratio of 50:50 v/v as eluent.The flow rate was 1 ml/min and eluent Accuracy, flupirtine, paracetamol, validation https://www.ijper.org/article/48/4s/s49-s55 2026-04-13T05:55:35.7423+00:00 Diclofenac Sodium Loaded Sustained Release Matrix Tablet Possessing Natural and Synthetic Polymers: Formulation and in vitro Characterization 2014-12-25 10.5530/ijper.48.4s.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4s-49.pdf Object: The objective of the present study was to investigate the effect of various concentrations of natural and synthetic polymers on in vitro drug release from sustained release matrix tablets. Materials and method: HPMC K4M and acacia gum were used as synthetic (hydrophilic) and natural (hydrophobic) polymers respectively. Diclofenac sodium was used as a model drug to study the in vitro release profile. Matrix tablets of Diclofenac sodium were fabricated by varying the concentrations of both HPMC K4M, Acacia, Matrix Tablet, Diclofenac Sodium, In vitro drug release https://www.ijper.org/article/48/4s/s132-s138 2026-04-15T06:32:17.711095+00:00 Effect of Extractive Phytoconstituents of Limonia acidissma Linn. and their probable mechanism against Phenothiazine Induced Extra Pyramidal Side Effects 2014-12-25 10.5530/ijper.48.4s.16 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4s-132.pdf Aim: The present study investigated the preventive effect and probable mechanism of ethanolic extract of Limonia acidissima (EELA) stem bark as compared to standard (L-dopa) in phenothiazine induced extra pyramidal side effects (catatonia) in experimental rats. The acute as well as chronic dose of chlorpromazine (CPZ) was administered to induce catatonia. Settings and Design: In case of acute study all the animals receive CPZ (8 mg/ kg) only on the 7th day followed by prior treatment of EELA whe Extra pyramidal side effects (EPS), Limonia acidissima linn, Chlorpromazine(CPZ), Catatonic severity, Hyperthermia, EELA https://www.ijper.org/article/48/4s/s93-s99 2026-04-13T05:55:35.7423+00:00 Taste Masked Quinine Sulphate Loaded Solid Lipid Nanoparticles for Flexible Pediatric Dosing 2014-12-25 10.5530/ijper.48.4s.12 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4s-93.pdf Introduction: Quinine Sulphate is an antimalarial agent usually indicated in the treatment of chloroquine resistant malaria. Objective: The objective of the present investigation was to prepare quinine sulphate loaded solid lipid nanoparticles by ultrasonic solvent emulsification technique using different surfactants (Tween 80, Poloxamer 407, Poloxamer 188) in order to mask the bitter taste, thereby improving patient compliance and to provide dose precision and a flexible system that allows dose Quinine Sulphate, Taste masking, Solid Lipid Nanoparticles, Glyceryl monostearate, Poloxamer 188, Poloxamer 407 https://www.ijper.org/article/48/4s/s100-s108 2026-04-13T05:55:35.7423+00:00 Formulation and Evaluation of Floating Microcapsules of Cefpodoxime Proxetil 2014-12-25 10.5530/ijper.48.4s.13 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4s-100.pdf Introduction: Floating drug delivery system is widely used technique to obtain higher bioavailability for drugs which have an absorption window in the stomach. Floating microcapsule is one approach to improve gastroretention for oral sustained release dosage forms. Cefpodoxime Proxetil has a biological half life of 2.5 h and is degraded at higher pH. Objective: Aim of this study was to develop floating microcapsules of Cefpodoxime Proxetil by solvent evaporation technique using Eudragit S100 as Cefpodoxime Proxetil, Floating microcapsule, Solvent evaporation technique, Eudragit S100, Optimization https://www.ijper.org/article/48/4s/s67-s72 2026-04-15T06:25:37.620005+00:00 Fast Dissolving Sublingual Films of Zolmitriptan : A Novel treatment approach for Migraine Attacks 2014-12-25 10.5530/ijper.48.4s.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4s-67.pdf Zolmitriptan, 5- Hydroxy tryptamine agonist is a new generation anti-migraine drug showing the oral bioavailability of only 40% as a result of hepatic first pass metabolism. The present research work is aimed to prepare sublingual dosage form of the Zolmitriptan with the purpose to achieve quick onset of action in management of severe migraine attacks. Fast dissolving sublingual films of Zolmitriptan were thus prepared by solvent casting method. Water soluble polymer hydroxyl propyl methyl cellu Zolmitriptan, fast dissolving sublingual film, film forming polymer HPMC E50 https://www.ijper.org/article/48/4s/s56-s66 2026-04-13T05:55:35.7423+00:00 Study of block copolymer micelles as vehicles for hydrophobic drug Lamotrigine 2014-12-25 10.5530/ijper.48.4s.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4s-56.pdf Objective: The objective of the study was to investigate the solubilization of poorly water-soluble drug Lamotrigine in pure & mixed Pluronic polymeric micelles. Method: Two different Pluronic (Pluronic F68, Pluronic L81) were chosen and micelle formulations were prepared by using various drug:polymer ratios and model drug Lamotrigine. Formulations were characterized by critical micellization concentration (CMC) values, cloud point of copolymers, micelle size and size distribution, zeta potentia Pluronic F68, Pluronic L81, Micelles, Solubilization https://www.ijper.org/article/48/4s/s118-s131 2026-04-15T06:31:30.281928+00:00 Design and Characterization of Gastroretentive Bilayer Tablet of Amoxicillin Trihydrate and Ranitidine Hydrochloride for H. pylori Infection 2014-12-25 10.5530/ijper.48.4s.15 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4s-118.pdf Objective: The present study was aimed at developing Gastroretentive Bilayer drug delivery systems containing Amoxicillin Trihydrate and Ranitidine Hydrochloride for the treatment of H. pylori induced peptic ulcer to minimize the side effect, improve the prolongation of action, to reduce the frequency of drug administration. Materials and Method: The tablet is characterized by immediate release layer of Ranitidine Hydrochloride and Gastroretentive layer of Amoxicillin Trihydrate. The formulation Amoxicillin Trihydrate, bilayer floating tablets, crospovidone, Ranitidine Hydrochloride, superdisintegrant https://www.ijper.org/article/48/4s/s109-s117 2026-04-15T06:29:45.285292+00:00 Formulation and Development of Fixed Dose Combination of Antihypertensive and Antidiabetic Agent for treatment of Co-existent Type Two Diabetes Mellitus and Hypertension 2014-12-25 10.5530/ijper.48.4s.14 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4s-109.pdf Objective: Coexistent Type Two Diabetes Mellitus (TTDM) and hypertension exposes patients to severe co-morbidities. Complex polypharmacy suggested by international organizations leads to the increased pill burden and decreased patient compliance which leads to worsening of conditions. Materials and Methods: Present research aims at the formulation and development of fixed dose combination (FDC) for treatment of coexistent hypertension and TTDM as it will help in increasing patient compliance. Li Coexistent type two diabetes mellitus and hypertension, Treatment for, coexistent type two diabetes mellitus and hypertension, Fixed Dose Combination of, Antihypertensive and Antidiabetic Agent, Fixed dose combination https://www.ijper.org/article/48/4s/s27-s33 2026-04-13T05:55:35.7423+00:00 A New Kinetic Approach. Stability of Cefquinome Sulfate under Variable pH and Temperature 2014-12-25 10.5530/ijper.48.4s.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4s-27.pdf Object: This study was evaluation of Cefquinome Sulfate (CS) long-term stability under different conditions of pH and temperature, so as to suggest the best conditions to perform its clinical application. Method: The CS stability was investigated at different values of pH (2.0-9.0) and temperature (4-370C). Kinetic parameters of CS degradation in alkaline environment were calculated adopting a new model that took into consideration the equilibrium between the active and a reversibly inactivated CS, Kinetic parameters, stability, Arrhenius https://www.ijper.org/article/48/4s/s18-s26 2026-04-15T06:18:41.972702+00:00 Formulation and Evaluation of Losartan Potassium Osmotic Controlled Matrix Tablets 2014-12-25 10.5530/ijper.48.4s.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4s-18.pdf Osmotically controlled oral drug delivery systems utilize osmotic pressure as energy source for the controlled delivery of drugs, independent of pH and hydrodynamic conditions of gastro intestinal tract (GIT). The present study was aimed to develop osmotic controlled extended release formulations of Losartan potassium an angiotensin II receptor antagonist with anti-hypertensive activity. Losartan potassium matrix tablets were prepared by direct compression process using HPMC K 15M as polymeric m Losartan potassium, osmotic pressure, micro drilling, controlled release https://www.ijper.org/article/48/4s/s1-s6 2026-04-13T05:55:35.7423+00:00 Screening of Mandarin Oil on Indomethcin Induced Inflammatory Bowel Disease in Wistar Rats 2014-12-25 10.5530/ijper.48.4s.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4s-1.pdf Objective: The present study investigates the protective effect of Mandarin Oil against Indomethacin (INDO) induced Inflammatory Bowel Disease (IBD) in male Wistar rats. Material and Method: IBD was induced by administration of indomethacin solution (7.5 mg/kg b.w., s.c) for 2 days. The study compromises of 5 groups (n=6), normal saline treated, disease induced, Mandarin Oil-I (200 mg/kg), Mandarin Oil-II (400 mg/kg) and Sulfasalazine (standard drug, 500 mg/kg b.w, p.o) treated group. After trea mandarin oil, inflammatory bowel disease, indomethacin, sulfasalazine and anti-oxidant https://www.ijper.org/article/48/4s/s139-s148 2026-04-13T05:55:35.7423+00:00 Antipsoriatic and Inhibitory effects of an oral dosage form containing Bioflavonoids on inflammatory cytokines IL-1α, IL-1β, IL-6, IL-8, IL-17 and TNF-α 2014-12-25 10.5530/ijper.48.4s.17 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4s-139.pdf Objective: The present study aimed to develop and evaluate orally administrable dosage form containing bioactive flavonoids viz., Luteolin-7-O-β-D-Glucuronide (II), Kaempferol 3-O-[2-O-(6-O-feruloyl)-β-D-glucopyranosyl]-β- D-galactopyranoside (III) from the bark of Givotia rottleriformis and Formononetin-7-O-β-D-glucoside (VI) from the leaves of Cassia tora. Methods: The formulation was developed and evaluated as per official compendia. The developed formulation was evaluated for antipsoriatic a Givotia rottleriformis, Cassia tora, Psoriasis, Formulation, Cytokines https://www.ijper.org/article/48/4s/s83-s92 2026-04-15T06:27:35.405853+00:00 New liquid chromatographic method for simultaneous quantification of Atovaquone and Proguanil with its active metabolite Cycloguanil in human plasma 2014-12-25 10.5530/ijper.48.4s.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4s-83.pdf Objective: The aim of the present study is to develop HPLC method for simultaneousquantification of atovaquone and proguanil with its active metabolite cycloguanilin human plasma. Methodology: A specific and accurate highperformance liquid chromatographic method has been developed using Phenyl (150×4.6 mm, 5 μm) column maintained at 18 °C. The separation was achieved using a mobile phase composed of phosphate buffer pH 7.2 and methanol (45:55%). The mobile phase was maintained at flow rate of 0. Atovaquone, Cycloguanil, Proguanil, Human plasma, Bioanalysis, HPLC https://www.ijper.org/article/48/4s/s40-s48 2026-04-15T06:22:57.518555+00:00 Formulation Development and Evaluation of Fast Disintegrating Tablets of Ambroxol Hydrochloride for Pediatrics- A Novel Approach for Drug Delivery 2014-12-25 10.5530/ijper.48.4s.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4s-40.pdf Objective: The objective of the present study was to prepare the fast disintegrating tablet of Ambroxol Hydrochloride for respiratory disorders such as bronchitis, asthma and cough for pediatrics. Material and Methods: The tablets were prepared by direct compression technique. Superdisintegrants such as Sodium Starch Glycolate was optimized. Different binders were optimized along with optimized superdisintegrant concentration. The tablets were evaluated for hardness, friability, weight variation Ambroxol Hydrochloride, Fast disintegrating tablet, Sodium starch glycolate, Optimization study, In-vitro Disintegration time https://www.ijper.org/article/48/4/66-73 2026-04-13T05:55:37.866597+00:00 Establishment of in vivo - in vitro Correlation: a Cogent Strategy in Product Development Process 2014-09-05 10.5530/ijper.48.4.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4-66.pdf Background: In vivo In vitro correlation (IVIVC) development and its validation is an extremely important phase of dosage form (new as well as generic) optimization. It is a liaison (preferentially linear) between a suitable pharmacokinetic parameter (peak plasma drug conc. i.e. Cmax, time for peak plasma drug conc. i.e. tmax and Area under the Curve i.e. AUC) and in vitro characteristics. Need: During optimization modifications in formulation composition, manufacturing method, required equipmen In vivo In vitro correlation, Biowaiver, Deconvolution, Convolution https://www.ijper.org/article/48/4/54-65 2026-04-13T05:55:37.866597+00:00 Highly Sensitive LC-MS/MS Method for Determination of Memantine in Rat Plasma: Application to Pharmacokinetic Studies in Rats 2014-09-05 10.5530/ijper.48.4.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4-54.pdf Background: A rapid and highly sensitive assay method has been developed and validated for the estimation of memantine (MEM) in rat plasma using liquid chromatography coupled to tandem mass spectrometry with electro spray ionization in the positive-ion mode. Method validation was performed as per United States Food and Drug Administration (US FDA) guidelines. Methods: The assay procedure involves a simple liquid-liquid extraction of MEM and phenacetin (internal standard, IS) from rat plasma usin Memantine, LC-MS/MS, Method validation, Rat plasma, Rat brain, Rat CSF, Pharmacokinetics https://www.ijper.org/article/48/4/6-10 2026-04-15T05:58:44.266991+00:00 Emerging Job Opportunities for PharmD Graduates: Looking Outside the Box 2014-09-05 10.5530/ijper.48.4.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4-6.pdf In India, PharmD program started in the year 2008 with the aim of increasing the scope of pharmacy to meet the current health care needs.1,2 At present, the Pharmacy council of India (PCI) has approved 160 pharmacy schools offering PharmD in India and near about half of them (70) are located in the southern state of Andhra Pradesh. 157 of the 160 PharmD offering schools are private institutions and universities. 3 A Pharm.D aspirant assumes that after completion of PharmD, he/she can diagnose, t Pharmaceutical, Pharm.D https://www.ijper.org/article/48/4/45-53 2026-04-13T05:55:37.866597+00:00 Simultaneous Determination of Metformin and Three Gliptins in Pharmaceutical Formulations Using RP HPLC: Application to Stability Studies on Linagliptin Tablet Formulation 2014-09-05 10.5530/ijper.48.4.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4-45.pdf Objective: A simple, rapid and validated liquid chromatographic method has been developed for the simultaneous determination of three novel Gliptins namely Vildagliptin (VLD), Sitagliptin (SIT) and Linagliptin (LIN) in their binary mixture with Metformin (MET). Methodology: The separation was performed on fast monolithic column using isocratic, mobile phase consisting of mixture of sodium dihydrogen phosphate, Sodium dedosyl sulphate and acetonitrile. The flow rate was 2.5 mL/min and UV detectio Metformin, Gliptins, Simultaneous determination, HPLC, degradation https://www.ijper.org/article/48/4/35-44 2026-04-15T06:10:24.534585+00:00 Synthesis and Characterization of Novel Sulphoxide prodrug of Famotidine 2014-09-05 10.5530/ijper.48.4.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4-35.pdf Background of the work: Famotidine, a H2 receptor antagonist is the drug of choice to treat ulcers in stomach (gastric and duodenal), erosive esophagitis (heartburn or acid indigestion) and gastroesophageal reflux disease (GERD). Drug molecules with limited aqueous solubility are becoming increasingly prevalent in the research and development portfolios of discovery focused pharmaceutical companies. Prodrugs are an established concept to overcome barriers like poor solubility to drug’s usefulnes Famotidine, Sulphoxide prodrug, Characterization, aqueous solubility, Characterization, Chemical, Hydrolysis, Log P https://www.ijper.org/article/48/4/11-21 2026-04-15T06:00:24.007237+00:00 Role of Pharmacy Education in National Development of Bangladesh: A Scope for Public and Private Sectors 2014-09-05 10.5530/ijper.48.4.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4-11.pdf Objectives: To explore the avenues in order provide a better strategic action plan that may help the Pharmacy Education to contribute for both public and private benefits. Methods: This paper adopts a qualitative research design and uses Bangladesh as a case. Qualitative methods were used that allowed interviewees to express their views in a free and personal way, giving as much prominence as possible to their thematic associations. Analysis of secondary data and intellectual debates were used w Pharmacy Education, Private and Public Sectors, Professional Education, Legislation, Bangladesh https://www.ijper.org/article/48/4/1-5 2026-04-13T05:55:37.866597+00:00 Accreditation of Pharmacy Institutions: Design of Curriculum 2014-09-05 10.5530/ijper.48.4.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4-1.pdf Background of accreditation and evaluation criteria have been discussed in the earlier two articles of this series. Design of the curriculum and its implementation is the core issue related to accreditation. Current article highlights how curriculum should be designed to meet the changing needs of the society. Linkage between Program Educational objectives (PEOs), Program Outcomes (POs) and Course Objectives (COs) is emphasized. Illustrative list of PEOs, POs and COs for B. Pharm. course has bee Accreditation, Curriculum Design, Autonomy, Pharmacy Institutions https://www.ijper.org/article/48/4/22-30 2026-04-13T05:55:37.866597+00:00 Evaluation of Competences at the Community Pharmacy Settings 2014-09-05 10.5530/ijper.48.4.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4-22.pdf The General Level Framework (GLF) document provides a model to be used in evaluating and upgrading of pharmacists’ competences currently used in many countries. This study has several Objectives: To show the adaptation process of the GLF document to the Serbian pharmaceutical work practices and regulations; to illustrate the implementation of the GLF document; to evaluate and monitor the development of pharmacists’ competencies. Materials and Methods: The adaptation, analysis, validation and adj General Level Framework, Competencies, Community Pharmacy, Pharmacists https://www.ijper.org/article/48/4/31-34 2026-04-13T05:55:37.866597+00:00 Evaluation of the Neuroprotective Effects of Centella asiatica Against Scopolamine Induced Cognitive Impairment in Mice 2014-09-05 10.5530/ijper.48.4.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-4-31.pdf Objective: This study was conducted to show Neuroprotective effect of aqueous extract of Centella asiatica in scopolamine induced cognitive impairment in mice. The improvement of cognitive impairment with Centella asiatica was compared against standard drug (Donepezil 50 μg/kg). Methods: Swiss albino mice (20–25 g) of either sex were randomly divided into 5 groups of 6 animals each. All the animals except the control group, received scopolamine (0.05 mg/kg) for 14 days. In day of 14th each anima Centella asiatica (CA), neuroprotection, scopolamine, donepezil, Elevated plus, Maze (EPM), cognitive impairment https://www.ijper.org/article/48/3/12-15 2026-04-13T05:55:38.733817+00:00 Pharmacy profession in India: Current scenario and Recommendations 2014-07-15 10.5530/ijper.48.3.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-3-12.pdf The Profession of Pharmacy is an integral part of the healthcare system worldwide. Pharmacies with well-organized practice can go a long way to ensure quality health care for the patient. In the past, pharmacists were responsible for dispensing medications only. Slowly, the traditional role of pharmacists is expanding and now pharmacists are playing a role as a vital team member in the direct care of patients, especially the new generation pharmacists who have Pharm. Ds. Pharmacists play a major Pharmacy, satisfaction, India, recommendations https://www.ijper.org/article/48/3/16-25 2026-04-15T05:36:00.517375+00:00 Multi-method Active Learning Approach: improving the educational experience in Pharmaceutical Drug Development 2014-07-15 10.5530/ijper.48.3.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-3-16.pdf Background: Improve educational experience, teaching effectiveness and learning outcomes remains one of the major educational challenges nowadays. Purpose: To determine the effect of organizing and teaching the Pharmaceutical Drug Development curricular unit using a Multi-method Active Learning Approach, MALA, as a novel teaching/learning strategy. Methods: MALA involved several different activities about pharmaceutical legislation, medicines production and validation process, Common Technical D MALA, Active learning approach, PBL, pharmaceutical drug development https://www.ijper.org/article/48/3/34-47 2026-04-13T05:55:38.733817+00:00 Structural Modification of Proteins and Peptides 2014-07-15 10.5530/ijper.48.3.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-3-34.pdf Proteins and peptides are ubiquitous in every cell and thus are vital for various biological functions. In recent years, there is an extensive growth in the development of various biologicals and large molecules like proteins and peptides. Now, they are replacing the market of existing organic based pharmaceuticals. This review article intends to summarize various structural modifications that are carried out in order to alter basic properties of peptides and proteins so that their solubility, a Proteins, peptides, Prodrugs, PEGylation, Polysialation, Lipidization, Hydrophobic ion pairing, Cylcodextrins, Nobex technology, Emisphere Technology https://www.ijper.org/article/48/3/80-90 2026-04-15T05:50:48.629859+00:00 Gamascintigraphic in Vivo-in Vitro Evaluation of Floating Matrix Tablet 2014-07-15 10.5530/ijper.48.3.10 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-3-80.pdf <strong>Background of the work:</strong> Gastroretentive drug delivery system can retain the dosage form in the gastric region for several hours. Prolong gastric retention helps in improving bioavailability and improves solubility of drugs that are less soluble in a high pH environment. For designing of GRDDS Atenolol was selected as a model drug. It has been used for the treatment of hypertension. Atenolol has short elimination half-life, stable at pH 1.2 and as the pH increase, the drugs becom Floating tablet, factorial design, Gamascintigraphy, antihypertensive model drug, HPMC, Locust bean, gum https://www.ijper.org/article/48/3/75-79 2026-04-15T05:48:54.189536+00:00 Quantitative Estimation of Asiatic acid, Asiaticoside & Madecassoside in two accessions of Centella asiatica (L) Urban for Morpho-chemotypic variation 2014-07-15 10.5530/ijper.48.3.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-3-75.pdf <strong>Aim and Scope:</strong> Two morphologically distinct accessions of Centella asiatica (SL and LL) from Indo-Gangetic plains of India were compared in relation to the levels of triterpenoid saponins. The plant was evaluated through its morphology, quantitative microscopy and physico-chemical tests. Materials and Methods: The metabolites madecassoside, asiaticoside and its sapogenin asiatic acid were analyzed and quantified by HPTLC. A comparison and evaluation of different parameters toget Asiatic acid, asiaticoside, madecassoside, C. asiatica, chemotype, morphotype https://www.ijper.org/article/48/3/91-98 2026-04-13T05:55:38.733817+00:00 A Simple, Novel Validated Stability Indicating RP-HPLC method for estimation of Duloxetine HCl in Capsule Pharmaceutical Formulation 2014-07-15 10.5530/ijper.48.3.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-3-91.pdf The object of current work was to study the degradation behavior of duloxetine under different ICH recommended stress condition under reverse phase high performance liquid chromatographic (HPLC) method and to establish a novel, validated stability-indicating reverse phase high performance liquid chromatographic method for the determination of duloxetine in presence of its impurities and forced degradation products in pharmaceutical formulation. The chromatographic separation was achieved on Hype Duloxetine, validation, degradation, HPLC https://www.ijper.org/article/48/3/1-5 2026-04-13T05:55:38.733817+00:00 Evaluating students’ experience of an integrated assessment: A case study in health promotion 2014-07-15 10.5530/ijper.48.3.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-3-1.pdf Objectives: To explore the engagement of second year pharmacy students in a South African University, in the implementation and evaluation of an integrated assignment. Methods: The integrated assignment focused on integrating the concepts of health promotion and pharmacotherapy of chronic non communicable diseases in the Anatomy and Physiology course. On completion, students engaged in a process of evaluation that focused on reflection of the assignment experience and their skills development. R ‘Evaluation’, ‘Health promotion’, 'Integrated assessment’, ‘Pharmacy’, ‘chronic non communicable, diseases https://www.ijper.org/article/48/3/99-103 2026-04-15T05:52:55.835887+00:00 Enhancement in Cortical Arousal by Caffeine Salicylate in Experimental Animal Models 2014-07-15 10.5530/ijper.48.3.12 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-3-99.pdf Objective: It is aimed to evaluate contribution of two molecules of Caffeine salicylate, a combinatorial product, in the CNS stimulant, anti-inflammatory and an analgesic property in experimental animal models. Material and Methods: Caffeine salicylate is synthecised by one step reaction from caffeine and salicylic acid. Actophotometer and open field test were used for the CNS stimulant activity whereas formalin induced rat paw edema and tail immersion test were used to evaluate anti-inflammator Caffeine salicylate, combinatorial, cortical arousal, adenosine, antioxidant https://www.ijper.org/article/48/3/6-11 2026-04-15T05:32:48.61813+00:00 Medication Adherence of Elderly Citizens in Retirement Homes Through A Mobile Phone Adherence Monitoring Framework (Mpamf) for Developing Countries: A Case Study in South Africa 2014-07-15 10.5530/ijper.48.3.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-3-6.pdf Background: This paper investigated medication adherence among elderly people in retirement villages in South Africa. A case study approach was used. Methods: Twelve participants were purposively selected from six retirement homes in Gauteng Province. Data collected used semi-structured open ended interview questions. Interviewees (elderly people above 60 years) were asked to tell in their own words different types of medicine taken daily, how many times, how often they forgot to take their medi Medication, Adherence, Elderly citizen, Retirement home, Mobile phones https://www.ijper.org/article/48/3/26-33 2026-04-13T05:55:38.733817+00:00 Internal factors Affecting Academic Performance among Pharmacy Students in Malaysian Public Institutions of Higher Learning 2014-07-15 10.5530/ijper.48.3.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-3-26.pdf Introduction: Several factors have been found to affect university students from achieving and maintaining good academic performance. Therefore, the objective of this study was to evaluate the internal factors that affect pharmacy students’ academic performance and to determine whether these factors have significant effect on their Cumulative Grade Point Average (CGPA) and year of study. Method: A questionnaire consisted of 47 items was used as the survey instrument in this study. A total of 1,0 Pharmacy education, academic performance, pharmacy students, internal factors https://www.ijper.org/article/48/3/48-59 2026-04-15T05:47:22.315695+00:00 Evaluation of Hydrophilic Polymers and their Combinations in Formulation of Sustained-Release Matrix Tablets of Water-Soluble Drug 2014-07-15 10.5530/ijper.48.3.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-3-48.pdf <strong>Aim of the work:</strong> The present study was aimed to investigate matrix-forming property of gum olibanum for sustained-release tablets of tramadol, a freely water-soluble drug. The possible synergistic effect of gum olibanum with hydroxypropyl methylcellulose (HPMC) and xanthan gum, and widely used pharmaceutical excipients on tablet properties was investigated. <strong> Methods: Matrix tablets were prepared containing polymers, either alone or in combinations, by wet granulation. Ta Diffusion, excipients, hydrophilic, similarity factor, gum olibanum https://www.ijper.org/article/48/2/41-47 2026-04-13T05:55:39.671497+00:00 Formulation of Gastroretentive Floating Drug Delivery System of Indomethacin 2014-04-21 10.5530/ijper.48.2.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-2-41.pdf Indomethacin (NASID) is used as potent anti-inflammatory drug with prompt antipyretic action, mainly used for the treatment of osteoarthritis with half-life of 4.5 hours. The basic objective of present work was to prepare floating delivery system of Indomethacin for once a day formulation using gas formation technique for prolonging the gastric residence time, so that the dosage regimen and gastric irritancy can be reduced. Indomethacin was estimated in the formulation by using UV/Visible spectr Floating drug delivery, Floating time, HPMC, Channeling agent https://www.ijper.org/article/48/2/16-34 2026-04-15T05:19:44.253839+00:00 Pharmocology Research in India: A Scientometric Analysis of Publications Output, 2003–12 2014-04-21 10.5530/ijper.48.2.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-2-16.pdf The study analyses the performance of Indian pharmacological research during the last ten years (2003–12) using publications data covered in Scopus database, based on several parameters including global publication share and rank of 15 most productive countries, India’s publication growth rate and citations impact, its pattern of citations output,international collaboration profile, institutional profile, geographical distribution of output, contribution and impact of top institutions and author Pharmacology, Scientometrics, Research output, India https://www.ijper.org/article/48/2/35-40 2026-04-13T05:55:39.671497+00:00 Promoieties Used In Prodrug Design: A Review 2014-04-21 10.5530/ijper.48.2.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-2-35.pdf Despite the success of various prodrugs, surprisingly no other reviews except a review on amino acids as promoieties, which elaborates about amino acids as prodrugs have been published to date. Therefore, we hope that this timely review using both marketed and investigational prodrugs as examples will be of interest for scientists working in the area of drug discovery and development as well as those working in the clinic. In the present commentary we have tried to summarize the different types Promoeity, prodrug, mutual prodrug, amino acid https://www.ijper.org/article/48/2/70-76 2026-04-15T05:28:52.257499+00:00 A Study On Incidence and Management of Preeclampsia In a Tertiary Care Hospital 2014-04-21 10.5530/ijper.48.2.10 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-2-70.pdf Background: Preeclampsia is a syndrome characterized by hypertension and proteinuria that occurs during the second and third trimester of pregnancy. It is a life threatening, multi-organ involvement disease and remains the leading cause of maternal death. Aim: The aim is to evaluate the prevalence and management of preeclampsia. Methods: A prospective Observational study was conducted over a period of six months at obstetrics and gynecology Department of Bharti hospital and Research centre, Pune preeclampsia, incidence, antihypertensive https://www.ijper.org/article/48/2/65-69 2026-04-15T05:27:41.254884+00:00 Estimation of Asiatic acid, Asiaticoside and Madecassoside in two accessions of Centella asiatica (L) Urban for Morpho-chemotypic variation 2014-04-21 10.5530/ijper.48.2.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-2-65.pdf Two morphologically distinct accessions of Centella asiatica (SL and LL) from Indo-Gangetic plains of India were compared in relation to the levels of triterpenoid saponins. The plant was evaluated through its morphology, quantitative microscopy and physico-chemical tests. The metabolites madecassoside, asiaticoside and its sapogenin asiatic acid were analyzed and quantified by HPTLC. A comparison and evaluation of different parameters together with triterpenoid content in these morphotypes are Asiatic acid, asiaticoside, madecassoside, C. asiatica, chemotype, morphotype https://www.ijper.org/article/48/2/48-54 2026-04-13T05:55:39.671497+00:00 Development and Validation of Stability-Indicating RP-HPLC Method for Determination of Indapamide and Amlodipine Besylate 2014-04-21 10.5530/ijper.48.2.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-2-48.pdf A new simple, accurate, precise and selective stability- indicating high performance liquid chromatographic (HPLC) method was developed and validated for simultaneous estimation of Amlodipine Besylate and Indapamide in tablet dosage form. An isocratic, reverse phase HPLC method was developed and validated using NUCLEOSIL C18 (250 x 4.6 mm, 5 μm) column and 0.01 M potassium dihydrogen phosphate buffer pH 3 and methanol (30:70 v/v) as mobile phase and detection is carried out at a wavelength of 24 Indapamide, Amlodipine besylate, HPLC, Stability https://www.ijper.org/article/48/2/77-86 2026-04-13T05:55:39.671497+00:00 Comparative Wound Healing Activity of two Polyherbal Formulations GC-01 and GC-02 on Experimentally induced Wounds in Rodents 2014-04-21 10.5530/ijper.48.2.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-2-77.pdf The present study was undertaken to support the use of herbs in folklore medicine for wound healing activity. In the present investigation, a comparative study and screening was done on two polyherbal formulations GC-01 and GC-02 fortified with different herb extracts in ghee for wound healing activity in experimentally induced wounds in rodents. Wound healing activity was evaluated by using three wound models viz. incision, excision and burn. For the study, standard drug used was Framycetinsulp Polyherbal formulation, incision, excision and burn wound model, antioxidant status https://www.ijper.org/article/48/2/1-3 2026-04-15T05:12:05.718241+00:00 Pharmacy Education system in India: Time to revisit teaching and training modules to meet global expectation 2014-04-21 10.5530/ijper.48.2.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-2-1.pdf The focus of higher education has witnessed a paradigm shift from mere addressing the needs of literacy to cater to wider global challenges. With success of opportunity based learning, it is clear that higher education should prepare an individual with outcome based learning, focusing on cognitive, affective and psychomotor skills. In this regard, the present article addresses some of the key components that need to be revised in the pharmacy education in line with development of Pharmaceuticals Pharmacy Education, Outcome based learning, Research based teaching, Quality Education https://www.ijper.org/article/48/2/4-8 2026-04-15T05:13:49.675678+00:00 Problem-based Learning in Medicinal Chemistry Laboratory from Pharmacy Students’ Perspective 2014-04-21 10.5530/ijper.48.2.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-2-4.pdf The aim of this research was to assess advantages and disadvantages of the modified version of PBL in Medicinal chemistry laboratory courses Method: This research was a self-control trial which means that the training method in the previous semester (non-PBL) was used as control. Seventy three students reflected the effectiveness of applying the modified version of PBL on a 19 item questionnaire. The reliability and validity of the questionnaire was confirmed by Cronbach- alpha test (r=0.72) and Problem-based Learning, Science Education, Medicinal Chemistry Laboratory, Pharmacy students https://www.ijper.org/article/48/2/9-15 2026-04-15T05:15:20.34362+00:00 State Anxiety, Stress and Burnout Syndrome Among Community Pharmacists: Relation With Pharmacists’ Attitudes and Beliefs 2014-04-21 10.5530/ijper.48.2.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-2-9.pdf State anxiety, work-related stress and burnout syndrome have been truly documented in health care workers. This research is focused to analize the relation of self-assessed degrees of state anxiety, work-related stress levels and burnout levels as well as their relation to pharmacists’ attitudes and beliefs towards their work with patients. The research design was cross-sectional and descriptive. A survey method by self-administered technique was used on the convenient sample of 647 community ph Burnout syndrome, Occupational stress, State anxiety, Attitudes and beliefs https://www.ijper.org/article/48/2/87-91 2026-04-15T05:30:35.639105+00:00 Spectrophotometric Method For Simultaneous Estimation of Montelukast Sodium and Ebastine in Bulk and Their Combined Tablet Dosage Form 2014-04-21 10.5530/ijper.48.2.12 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-2-87.pdf A simple spectrophotometric method has been developed for simultaneous estimation of Montelukast Sodium and Ebastine from tablet dosage form. Absorbance correction method in which absorbance is measured at two wavelengths, 345 nm at which Ebastine has no absorbance and 253 nm at which both the drugs have considerable absorbance. This method was found linear between the range of 5-25 μg/ml for Montelukast Sodium and Ebastine. The accuracy and precision were determined and found to comply with ICH Montelukast Sodium, Ebastine, Absorbance correction method https://www.ijper.org/article/48/2/55-64 2026-04-15T05:24:24.996091+00:00 Effect of vasectomy on testis and epididymis in adult male Swiss albino mice: Histological and histometric study 2014-04-21 10.5530/ijper.48.2.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-2-55.pdf Objective: To study the short- and long-term effects of vasectomy on the testis and epididymis in adult male Swiss albino mice. Methods: Healthy adult male Swiss albino mice were divided into three groups, viz., control group (n=6), sham control group (n=6) and vasectomized experimental group (n=12). Vasectomy was performed on the mice in the vasectomized experimental group, and the sham-operated control group were made to undergo a surgical procedure but not vasectomy. Half of the animals in th Spermatogenesis, vasectomy, histometric analysis https://www.ijper.org/article/47/4/65-72 2026-04-13T05:55:41.072038+00:00 High-performance Liquid Chromatographic Determination of Paracetamol, Propyphenazone, and Caffeine in Pharmaceutical Formulations 2014-01-30 10.5530/ijper.47.4.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-47-4-65.pdf This study proposes a liquid chromatography (RPHPLC) method for quantitative analysis of the most widely prescribed combination of Paracetamol, Propyphenazone and Caffeine in tablet dosage form in presence of Rasagiline as an internal standard. The chromatography was performed on a Gracesmart C18 column (5μm, 250mm×4.6mm i.d.) using the mixture of water and 2-propanol in the ratio 80:20 v/v as mobile phase. The pH of aqueous phase was adjusted to 3.0 with 1% o-phosphoric acid and a flow rate was RPHPLC, Paracetamol, Propyphenazone, Caffeine, Rasagiline, Internal standard https://www.ijper.org/article/47/4/49-58 2026-04-13T05:55:41.072038+00:00 Development and Physicochemical, In Vitro and In Vivo Evaluation of Transdermal Patches of Zaleplon 2014-01-30 10.5530/ijper.47.4.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-47-4-49.pdf The aim of the present work was to develop and evaluate matrix type transdermal therapeutic system of zaleplon (ZLP) with different ratios of hydrophilic and hydrophobic polymeric combinations. Formulations A1, A2, A3 were composed of Eudragit RL100 (ERL) and hydroxypropyl methyl cellulose (HPMC) in 1:3, 1:1, 3:1 ratios; A4, A5, A6 were composed of Eudragit RS100 (ERS) and hydroxypropyl methyl cellulose in 1:3, 1:1, 3:1 ratios. All the six formulations carried 10mg of ZLP/patch area, 6% v/w of d Zaleplon, Transdermal, Limonene, Eudragit, Hydroxypropyl Methyl Cellulose https://www.ijper.org/article/48/1/1-5 2026-04-15T04:46:56.628661+00:00 Accreditation of Pharmacy Institutions: Evaluation Criteria 2014-01-30 10.5530/ijper.48.1.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-1-1.pdf The background under which new accreditation norms have been revised, have been discussed earlier.1 In order to face the actual process of accreditation, one needs to know guidelines and operating procedures for accreditation. The article discusses background regarding Self Assessment Report (SAR) and content therein. A comparison between old and new accreditation criteria also is presented in the current article. Composition and functioning of evaluation committees is highlighted. Documentation Self Assessment Report (SAR), accreditation criteria, Programme Educational Objectives (PEOs) https://www.ijper.org/article/48/1/69-74 2026-04-13T05:55:40.449121+00:00 Development and Evaluation of Mucoadhesive Buccal Tablets of Ketorolac Tromethamine 2014-01-30 10.5530/ijper.48.1.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-1-69.pdf Buccal route offers excellent opportunities and potential advantages for systemic drug delivery as compared to per-oral administration. The objective of this study was to prepare mucoadhesive tablets of Ketorolac tromethamine in order to circumvent the gastric irritation associated with the drug. The tablets were prepared using various hydrophilic polymers like Hydroxy propyl methyl cellulose K4M (HPMC), Carbopol 934P (CP) and xanthan gum singly and in combination, by direct compression followed Ketorolac tromethamine, mucoadhesive, swelling index, direct compression https://www.ijper.org/article/47/4/1-6 2026-04-13T05:55:41.072038+00:00 Objective Structured Clinical Examination in Pharm D and Clinical Pharmacy Courses in India; a Rising Need to Acquaint? 2014-01-30 10.5530/ijper.47.4.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-47-4-1.pdf At hand is a rising need to acquaint with objective structured clinical examination (OSCE) as a part of pharmacy exams in India. OSCE is a recognized, consistent, and active assessment to valuate professional skills in an impartial and an obvious method. All OSCE station desires to obligate a marking scheme that covers communication skills and content skills assessing the chores expected from the students. Mostly, OSCE stations have active, preparatory and rest stations. These stations may compr OSCE, Clinical pharmacy, Pharm D, India https://www.ijper.org/article/48/1/56-60 2026-04-15T05:02:17.325782+00:00 Fungal Biotransformation of Fenofibrate 2014-01-30 10.5530/ijper.48.1.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-1-56.pdf Screening studies were performed using eight fungal organisms for their potential to biotransform the drug fenofibrate to its active metabolite fenofibric acid. Among all fungi screened, only Aspergillus terreus shown an extra peak at 2.64 m compared to its controls indicating formation of metabolite. The metabolite thus formed was identified, isolated and structure was confirmed by HPLC, LCMS, IR and PNMR. Aspergillus terreus biotransformed the fenofibrate to its metabolite fenofibric acid. The Biotransformation, fungi, fenofibrate fenofibric acid, Aspergillus terreus https://www.ijper.org/article/48/1/17-26 2026-04-15T04:53:36.913316+00:00 Exploring computer simulation to assess counseling skills amongst pharmacy undergraduates 2014-01-30 10.5530/ijper.48.1.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-1-17.pdf Pharmacists are considered medicine specialists referring to minor ailment treatment and self-medication counseling. Although increasingly important in pharmacy training, there are limited initiatives comprising the use of computer simulation. The study objective was to explore minor ailment counseling skills from Portuguese pharmacy undergraduates through an experimental virtual patient methodology. This study followed a prospective cross-sectional design, with all students from Portuguese high Virtual patients, Self-medication counseling, Computer simulation, OTC advice giving, Electronic, assessment https://www.ijper.org/article/48/1/39-48 2026-04-13T05:55:40.449121+00:00 The Chemopreventive Effect of Nigella Sativa on 1,2-dimethylhydrazine-induced Colon Tumor 2014-01-30 10.5530/ijper.48.1.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-1-39.pdf In this study, the chemopreventive efficacy of Nigella sativa seed powder as an important chemopreventive herb on the formation of colon tumor has been examined through measuring the levels of hepatic oxidative stress and metabolizing enzymes in 1,2-dimethylhydrazine (DMH)-induced colon cancer in rats. Male Wistar rats were divided into 6 groups as untreated control, Sham, DMH (30mg/kg b.w) received carcinogen via subcutaneously (s.c) injection once a week for 18 weeks and treatment groups recei Nigella sativa, Colon tumor, DMH, Antioxidant parameters, Xenobiotic metabolizing enzymes https://www.ijper.org/article/48/1/61-68 2026-04-15T05:04:57.483796+00:00 Characterization of Bio-Active Nanoparticles – Bhasma an Indian Ayurvedic Drug 2014-01-30 10.5530/ijper.48.1.10 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-1-61.pdf Bhasmas are the multi elemental drugs derived from natural resources. Physicochemical analysis of various bhasmas supplied by different manufacturers has been reported. Particle size analysis has been done using dynamic light scattering technique. The size of bhasma particle is in the of the order of 1000nm. Chemical analysis of soluble matter of bhasma has been done using inductively coupled plasma – atomic emission spectroscopy technique. Elemental composition of bhasma differs from supplier t Bhasma, ICP-AES analysis, Dynamic Light Scattering, Nano-particles https://www.ijper.org/article/47/4/24-30 2026-04-13T05:55:41.072038+00:00 In Vitro Antioxidant Activity and HPTLC Analysis of Borago Officinalis Linn. 2014-01-30 10.5530/ijper.47.4.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-47-4-24.pdf Borage (Borago officinalis L.) is known drug in Unani system of medicine which is very popular as Gaozaban and used in various khamira (semi solid Unani formulations) for cardioprotection. In the present study, a comparative antioxidant potential of different extracts of borage leaves along with rosmarinic acid (positive marker of the drug) was carried out using DPPH and nitric oxide free radical scavenging method prior to estimated total phenolic content in each extract. The suitable solvent sy Borago officinalis L, antioxidant activity, HPTLC, quality control, rosmarinic acid https://www.ijper.org/article/47/4/31-48 2026-04-13T05:55:41.072038+00:00 Synthesis and preliminary evaluation of a focused chalcone library for anti-inflammatory activity 2014-01-30 10.5530/ijper.47.4.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-47-4-31.pdf A series of monosubstituted chalcones with potential anti-inflammatory activity have been rationally designed leading to a focused library of ligands 4a-j with ring-A substitution. Subsequent to drug-likeness and druggability assessments, the library members were synthesized in optimal yields and their structures were confirmed by IR, 1H NMR, 13C NMR and mass spectral analysis. Screening for anti-inflammatory activity revealed that most of the compounds were quite effective in containing inflamm Chalcones, structure-activity relationship, drug-likeness, anti-inflammatory activity https://www.ijper.org/article/47/4/79-87 2026-04-13T05:55:41.072038+00:00 Modified Xanthan Gum as Hydrophilic Disintegrating Excipient for Rapidly Disintegrating Tablets of Roxithromycin 2014-01-30 10.5530/ijper.47.4.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-47-4-79.pdf A hydrophilic excipient that could modulate the disintegration time was developed as disintegration aid for the tablets of the model drug roxithromycin. Xanthan gum (XG) was modified by sequential processes to obtain treated xanthan gum (TXG) and co-grinded with mannitol to produce co-grounded treated xanthan gum (C-TXG) and was characterized by Scanning Electron Microscopy (SEM), Diffuse Reflectance Spectroscopy (DRS) and X-Ray Diffraction (XRD). SEM revealed structural changes attributable to Roxithromycin, modified xanthan gum, micromeritic properties, crystallinity index, rapidly disintegrating, tablets https://www.ijper.org/article/48/1/6-12 2026-04-13T05:55:40.449121+00:00 Social Pharmacy as a Field of Study in Undergraduate Pharmacy Education 2014-01-30 10.5530/ijper.48.1.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-1-6.pdf Objective: To ascertain and compare the differences, extent and depth of education in Social Pharmacy and reveal international regional variations. To analyze Social Pharmacy education at different pharmaceutical faculties. To examine the range and scope of teaching subjects partially related to the social, behavioral and administrative pharmacy sciences. Methods: A questionnaire survey was developed based on the examination of the study plans of 15 pharmacy schools around the world. A questionn Social Pharmacy, curriculum, undergraduate, pharmacy education https://www.ijper.org/article/48/1/13-16 2026-04-15T04:51:20.256875+00:00 An Innovative Course “The Comprehensive Experiments and Experimental Design of Basic Medicine”: A Case of Third Military Medical University in China 2014-01-30 10.5530/ijper.48.1.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-1-13.pdf An important goal of contemporary medical education is to cultivate and improve the comprehensive and innovative abilities of medical students. One significant way to fulfill this goal is to explore the course reform of experimental teaching in basic medicine. A new course named “The Comprehensive Experiments and Experimental Design of Basic Medicine”, is developed targeting the senior students in Chinese medical university in recent years. As an independent experimental course, it is a good tea Medical education, Course reform, Experimental design, Innovative ability https://www.ijper.org/article/48/1/27-31 2026-04-15T04:56:10.291676+00:00 Comparison of Conventional and Novel Extraction Techniques for the Extraction of Scopoletin from Convolvulus Pluricaulis 2014-01-30 10.5530/ijper.48.1.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-1-27.pdf Conventional extraction techniques like soxhlet extraction and reflux extraction and novel extraction techniques like Supercritical Fluid extraction (SFE), Ultrasonic Assisted Extraction (UAE) and microwave assisted extraction method (MAE) were used for the extraction of Convolvulus Pluricaulis. The scopoletin content in the extracts obtained using different extraction techniques was estimated using pre validated HPTLC method. The conventional and novel extraction techniques were compared on the Scopoletin, Ultrasound assisted extraction, Supercritical fluid extraction, Microwave assisted extraction https://www.ijper.org/article/47/4/73-78 2026-04-13T05:55:41.072038+00:00 Pre-Clinical Evolutionary Study of Alpha-Pinene in L-Arginine Induced Acute Pancreatitis in Rat. 2014-01-30 10.5530/ijper.47.4.10 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-47-4-73.pdf Objective: Screening of alpha-pinene on L-arginine induced acute pancreatitis model. Material and Methods: In this model the acute pancreatitis was determined at 24h by determination of pancreatic wet weight/body weight ratio, nitrate/nitrite levels, lipid peroxidation (thiobarbituric acid reactive substances (TBARS)], proinflammatory cytokines [tumor necrosis factor (TNF)-α, C-reactive proteins (CRP) and interleukin (IL)], pancreatic myeloperoxidase (MPO) activity and serum levels of amylase an Acute pancreatitis, Anti-inflammatory, Cytokines, L-arginine, alpha-pinene https://www.ijper.org/article/48/1/32-38 2026-04-15T04:58:44.030272+00:00 Effect of Pioglitazone, Quercetin, and Hydroxy Citric Acid on the Lipid Profile and Lipoproteins in Experimentally Induced Non-alcoholic Steatohepatitis (NASH) 2014-01-30 10.5530/ijper.48.1.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-48-1-32.pdf Background: Non-alcoholic steatohepatitis (NASH) is an emerging disease belonging to the non-alcoholic fatty liver disease (NAFLD) spectrum, which may progress to fibrosis and thereby to cirrhosis of the liver. Currently, no definitive and effective treatment strategies have been identified to treat NASH. Objective: To study the effect of pioglitazone, quercetin, and hydroxy citric acid on lipid profile parameters and lipoproteins in experimentally induced non-alcoholic steatohepatitis (NASH). M Non-alcoholic steatohepatitis, lipid profile, lipoproteins, quercetin, hydroxy, citric acid, pioglitazone https://www.ijper.org/article/47/4/59-64 2026-04-13T05:55:41.072038+00:00 In vitro Dynamics of Ibuprofen Incorporated Proniosomal Gel 2014-01-30 10.5530/ijper.47.4.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-47-4-59.pdf Aim: The research was aimed to encapsulate the ibuprofen with proniosomal gel and facilitate ibuprofen release in sustained manner for sustained drug release. Methods: Different proniosomal gels of ibuprofen were formulated with Span 20/Span 80 and soya lecithin using the method described in literature. In all formulations cholesterol concentration was kept constant. The prepared proniosomal gels were evaluated for chemical incompatibility by FT-IR, vesicle size analysis, encapsulation efficienc encapsulation efficiency, permeation, flux, fickian diffusion, transdermal delivery https://www.ijper.org/article/47/4/7-15 2026-04-13T05:55:41.072038+00:00 Rationality of Prescription Writing 2014-01-30 10.5530/ijper.47.4.2 Prescription writing is one of the crucial tasks performed by the health professionals. A prescription is an instruction from prescriber to a patient as well as dispenser. Use of proper format for prescription writing ensures appropriate use of drug and helps in minimizing errors. Health professionals must take account of appropriateness, effectiveness, side effects, contraindications and cost when prescribing any medicine. Special care and precautions are needed in prescribing the drugs with ab Components of prescription, prescribing errors, rational use of drug https://www.ijper.org/article/47/4/16-23 2026-04-13T05:55:41.072038+00:00 Global Metadata Analysis of Research Publications in Pharmaceutical Sciences 2014-01-30 10.5530/ijper.47.4.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-47-4-16.pdf The aim of the present work was orienting to generate information about global research publications in Pharmaceutical sciences. Method adopted for this dry lab project was assimilation of metadata analysis, processing and interpretation. Results showed that hierarchy of countries sourcing journals (total journals-percentage global share) were in the descending order of USA>UK>Germany>Canada and France>Netherlands> China>Spain>Finland>Denmark, Egypt, Georgia, India, Israel, Japan, Sweden, Switze database, Science Citation Index, impact factor, metadata https://www.ijper.org/article/47/3/49-55 2026-04-13T05:55:43.099091+00:00 Formulation and Evaluation of Fast Dissolving Tablets of Ondansetron by Solid Dispersion in Superdisintegrants 2013-11-16 10.5530/ijper.47.3.8 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-47-3-49.pdf Ondansetron Hydrochloride (OSH) is a sparingly water-soluble drug. The aim of the present investigation was to prepare solid dispersion (SD) of OSH using superdisintegrants as carrier and formulate it as fast dissolving tablets (FDTs) with an objective to improve solubility and enhance dissolution of drug. SD of drug using superdisintegrants like croscarmellose sodium (CCS), crospovidone (CP), sodium starch glycolate (SSG), and low substituted hydroxy propyl cellulose (L-HPC) respectively as car OSH, Superdisintegrants, Solid dispersions, Fast dissolving tablets https://www.ijper.org/article/47/3/6-13 2026-04-13T05:55:43.099091+00:00 Chinese Pharmacy Undergraduate Attitudes toward Game-Based Learning in Pharmaceutical Education 2013-11-16 10.5530/ijper.47.3.2 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-47-3-6.pdf Game-based learning (GBL) is a student-centered and active-learning method. But the implementing model of current GBL was not adequately consulted with students, who are the real subject and target of GBL. Thus we sought to evaluate Chinese pharmacy undergraduates’ attitudes of GBL in pharmaceutical education, and the favorite implementation model of GBL to provide a more individualized and targeted teaching approach. A GBL questionnaire was administered to all the pharmacy undergraduates except Pharmacy undergraduates, game-based learning, attitudes, China https://www.ijper.org/article/47/3/31-41 2026-04-13T05:55:43.099091+00:00 Development of Valproic Acid Niosomal in situ Nasal Gel Formulation for Epilepsy 2013-11-16 10.5530/ijper.47.3.6 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-47-3-31.pdf Valproic acid is an anti-epileptic drug used in the treatment of epilepsy and seizures. The study was designed with three aims. Firstly, to enhance the solubility and bioavailability of BCS class II drug Valproic acid; secondly, to ease administration of the formulation to the epileptic patient, during an attack, and thirdly, to reduce the dose of drug for long-term treatment. In the culmination of this study, an anti-epileptic drug loaded (Valproic acid) niosomal gel for nose-to-brain-delivery Valproic Acid, niosome, in-situ nasal gel, Gelation study, Enthalpy study, Histopathology https://www.ijper.org/article/47/3/26-30 2026-04-13T05:55:43.099091+00:00 Current Scenario of Patent Act: Compulsory Licensing 2013-11-16 10.5530/ijper.47.3.5 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-47-3-26.pdf Process of compulsory licensing glared after the Doha declaration. Doha declaration explored the way for compulsory licensing around the globe and also insisted that TRIPS agreement does not and would not prevent any member from taking measure to protect public health. After Doha Declaration many countries aggressively amended their patent regime for purpose of compulsory licensing. Compulsory license can be issued to a generic company on different grounds to fulfill the patient need and to impr Compulsory license, Patent, Innovation, Generic drugs, Intellectual property right https://www.ijper.org/article/47/3/1-5 2026-04-13T05:55:43.099091+00:00 Mannequin-Simulator as a New Teaching and Learning Method in Performance-Based Pharmacotherapy 2013-11-16 10.5530/ijper.47.3.1 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-47-3-1.pdf Introduction: Active learning approach is deemed to be important for performance-based education. Aims: Objectives of this study were to report experience in employing a mannequin-based case assessment of pharmacotherapy for pharmacy students and to seek students’ opinion on the usefulness of this approach. Methods: Students were exposed to a standardised heart failure case using mannequin-simulator and were asked to evaluate the medication prescribed and to manage any drug related problems. Per Simulation-based, active learning, pharmacotherapy, performance-based https://www.ijper.org/article/47/3/42-48 2026-04-13T05:55:43.099091+00:00 Design and In Vitro Evaluation of Pentoxifylline- Polyelectrolyte Complex Tablets 2013-11-16 10.5530/ijper.47.3.7 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-47-3-42.pdf The study evaluates the possibility of using polyelectrolyte complexes (PECs) in the form of mucoadhesive matrix tablets to achieve a prolonged drug release profile of Pentoxifylline suitable for peroral administration. PECs were formed by different ratios and combination of polymers (chitosan–alginate, chitosan-carbopol and chitosan– carrageenan) and were dried by lyophilisation. Characterization was performed by Fourier Transform-Infrared (FT-IR) spectroscopy and X-Ray Diffraction (XRD) studie Carbopol 934P, Carrageenan, Chitosan, Pentoxifylline, Polyelectrolyte complex, Sodium Alginate https://www.ijper.org/article/47/3/56-63 2026-04-13T05:55:43.099091+00:00 Design and Evaluation of Rapidly Disintegrating Tablets of Racecadotril with Enhanced in-vitro Dissolution Achieved by Solid Dispersion Technique 2013-11-16 10.5530/ijper.47.3.9 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-47-3-56.pdf Racecadotril is an antidiarrheal drug which acts as a peripherally acting enkephalinase inhibitor. It is a solubility limited compound and thus the bioavailability can be improved by increasing its aqueous solubility. Solid dispersions of racecadotril were prepared using polymers β-cyclodextrin, poloxamer 188 (Lutrol F 68) and poloxamer 407 (Lutrol F127) in different proportions (1:1, 1:3, 1:5 and 1:10). Solvent evaporation method was employed using methanol as solvent. The solid dispersion comp Racecadotril, Solid dispersion, Poloxamer 188, Poloxamer 407 https://www.ijper.org/article/47/3/19-25 2026-04-13T05:55:43.099091+00:00 Approach to the Integration of Management Systems in a Pharmaceutical Organization 2013-11-16 10.5530/ijper.47.3.4 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-47-3-19.pdf This paper discusses how a system approach to management can be used for the development and implementation of an integrated management system (IMS) in a company producing medicinal products. It is argued in the paper that approaches to the solutions of how to integrate management systems all require two elements: a conceptual model and a supporting methodology. Although a large number of models has been developed that could provide the basis for integration, development of methodologies to achi IMS, Quality, Management, ISO, GMP, PDCA https://www.ijper.org/article/47/3/64-69 2026-04-13T05:55:43.099091+00:00 Determination of Some Diuretic Drugs in Pure form and Their Pharmaceutical Formulations with Ammonium Hexanitratocerate (IV) 2013-11-16 10.5530/ijper.47.3.10 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-47-3-64.pdf A quick, convenient and simple titrimetric method for determination of diuretic drugs e.g., acetazolamide, furosemide, hydrochlorothiazide, mannitol and spironolactone in pure form and in their pharmaceutical formulations viz., diamox (tab), synomax (tab), tebemid (tab), frusemene (tab), aquazide (tab), xenia (tab), kratol (inj), mannigyl (inj), aldactide (tab) and spilactone (tab) with ammonium hexanitratocerate (IV) reagent have been reported. It is a versatile oxidizing agent of cerium (IV) a Diuretics, Pharmaceuticals, Ammonium hexanitratocerate (IV), Oxidizing agent, Titration https://www.ijper.org/article/47/3/14-18 2026-04-13T05:55:43.099091+00:00 The Effectiveness of Problem-Based Learning on Evidence Based Medicine: A Double-Blind Randomized Trial 2013-11-16 10.5530/ijper.47.3.3 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-47-3-14.pdf Problem-based learning is recognized as promoting integration of knowledge and fostering a deeper approach to life-long learning, but is associated with significant resource implications. This paper utilizes preliminary data from both the facilitator and postgraduate viewpoint to determine whether the use of this novel methodology is feasible with large groups of postgraduates in evidence based medicine. To investigate the effectiveness of problem-based learning (PBL) in comparison with lecture- Problem-based learning, Evidence-based medicine, Postgraduate https://www.ijper.org/article/47/3/70-76 2026-04-13T05:55:43.099091+00:00 Formulation and Evaluation of Mucoadhesive Buccal Films of Esomeprazole Magnesium Trihydrate 2013-11-16 10.5530/ijper.47.3.11 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-47-3-70.pdf The purpose of this study was to develop formulation and systematically evaluate in vitro performances of mucoadhesive patches of Esomeprazole magnesium trihydrate using HPMC K4M, HPMC (15cps), and HPMC (5cps) for avoiding gastric degradation and prolong the release up to 8 h. The films were smooth and elegant in appearance, uniform in thickness, weight, drug content and good folding endurance. Drug and polymer incompatibility was not shown in FTIR study. In-vitro release studies were reveal tha Esomeprazole magnesium trihydrate, Buccal patches, In-vitro drug release, Ex-vivo permeation https://www.ijper.org/article/47/3/77-81 2026-04-13T05:55:43.099091+00:00 Determination and Quantification of Ferulic acid in Ferula asafoetida by a Validated HPTLC Method 2013-11-16 10.5530/ijper.47.3.12 https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-47-3-77.pdf Phenolic acids are a group of compounds categorized as plant secondary metabolites widely distributed in plant kingdom and which furnishes with a number of applications. The oleo gum resin obtained from Ferula asafoetida commonly known as ‘HING’ possess ferulic acid which is one of a phenolic acid as an ingredient with a potent pharmacological activity. In the present study an attempt has been made to develop an HPTLC method for the quantitative estimation of ferulic acid from Ferula asafoetida. HPTLC, Ferula asafoetida, ferulic acid, method validation https://www.ijper.org/article/46/4/352-359 2026-04-13T05:55:45.405739+00:00 Anti-diabetic Activity of Diplocyclos palmatus Linn. in Streptozotocin-Induced Diabetic Mice 2012-12-31 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-4-352.pdf The anti-diabetic activity of methanolic extract of seed of Diplocyclos palmatus Linn. (Cucurbetaceae) was evaluated in streptozotocin-induced diabetic mice. Methanolic extract of the seed (150 mg/kg body weight), was administered orally to male Swiss albino mice. Streptozotocin was used to induce diabetes mellitus. The anti-diabetic potential was assessed by determining oral glucose tolerance, fasting blood glucose, urine glucose, liver glycogen content, serum lipid profile, change in body weig Diplocyclos palmatus, Seeds, Streptozotocin, Diabetes https://www.ijper.org/article/46/4/318-322 2026-04-13T05:55:45.405739+00:00 Design and Evaluation of Fast Dissolving Films Containing Nizatidine 2012-12-31 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-4-318.pdf The present study deals with the formulation of fast dissolving films of nizatidine as a model drug which is used for the treatment of acid-reflux disorders, peptic ulcer disease, and active duodenal ulcer. Rapidly dissolving dosage forms have acquired great importance in pharmaceutical industry because of their unique properties. In the present research work various trails were carried out using maltodextrin and the concentration of excipients were optimized to prepare an ideal film for drug lo Fast dissolving Films, Nizatidine, Taste masking https://www.ijper.org/article/46/4/372-377 2026-04-13T05:55:45.405739+00:00 Modulatory Effect of a-tocopherol in Simvastatin and Gemfibrozil Induced Rhabdomyolysis in Rats 2012-12-31 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-4-372.pdf The present study was aimed to evaluate the protective effect of α-tocopherol in simvastatin and gemfibrozil induced rhabdomyolysis in rats. HMG-Coenzyme A reductase inhibitors are the most widely used drug for the treatment of hyperlipidemias but their long term use is associated with rhabdomyolysis. Administration of simvastatin (80 mg/kg, p.o.) and gemfibrozil (600mg/kg, p.o. twice) for 30 days produced significant increase in the level of various serum parameters (creatine Phospho kinase, ur Antioxidant, α-tocopherol, Gemfibrozil, Oxidative stress, Rhabdomyolysis, Simvastatin https://www.ijper.org/article/46/4/312-317 2026-04-13T05:55:45.405739+00:00 The Potential of Trigonella foenum-graecum L. Seed Mucilage as Suspending Agent 2012-12-31 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-4-312.pdf The present study deals with the evaluation of mucilage isolated from fenugreek (Trigonella foenum-graecum L.) seeds (commonly named methi) as an innovative and cheap suspending agent. Zinc oxide suspensions (20 % w/v) were prepared using fenugreek seed mucilage as a suspending agent and it was evaluated to find its stability using the parameters like, sedimentation profile, degree of flocculation and redispersibility. The effect of the tested mucilage on suspension was compared with various com suspension, suspending agent, mucilage, fenugreek seed https://www.ijper.org/article/46/4/340-345 2026-04-13T05:55:45.405739+00:00 Antidiabetic Activity of Pandanus odoratissimus Root Extract 2012-12-31 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-4-340.pdf The aqueous ethanolic extract of Pandanus odoratissimus (Pandanaceae) root was tested for its effect on blood glucose levels in normal and diabetic rats. Hypoglycemia was observed in basal conditions when tested at an oral dose of 75, 150 and 300 mg/kg body weight. The ethanolic extract has displayed a significant dose-dependent antihyperglycemic activity in oral glucose tolerance test and also found to reduce the increased blood glucose in alloxan-induced diabetic rats (37% at 150 mg/kg and 51% Pandanus odoratissimus, alloxan, glucose tolerance, diabetes, roots, antihyperglycemia, antioxidant activity https://www.ijper.org/article/46/4/323-329 2026-04-13T05:55:45.405739+00:00 Enhancement of Dissolution Rate of Irbesartan by Chitosan based Crystal Engineering Technique 2012-12-31 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-4-323.pdf The objectives of present investigations were to enhance dissolution rate of irbesartan by using chitosan and chitosan chlorhydrate and optimize an effective concentrations of both. Cocrystals of irbesartan (IB) were prepared by solvent change technique.Chitosan solution was prepared by soaking chitosan and chitosan chlorhydrate in glacial acetic acid. A weighed amount of drug was dispersed in chitosan solution by stirring. The dispersion was added to sodium citrate solution to precipitate chit Pharmaceutical, Co-crystals, Chitosan https://www.ijper.org/article/46/4/346-351 2026-04-13T05:55:45.405739+00:00 Synthesis and Evaluation of Antiproliferative activity of 1, 2, 4-Triazole Derivatives Against EAC Bearing Mice Model 2012-12-31 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-4-346.pdf A series of potential bioactive compounds, 4-Amino- 5-mercapto- 3-(4-chlorophenyl)-1, 2, 4-triazole (1d), 4-Amino- 5-mercapto- 3-(4-nitrophenyl)-1, 2, 4- triazole (2d) , 4-Amino- 5-mercapto-3-(2, 4-dichlorophenyl)-1,2, 4-triazole (3d), 4-Amino- 5-mercapto- 3-(2-chlorophenyl)-1,2, 4-triazole (4d), 4-Amino- 5- mercapto- 3-(2-methylphenyl)-1, 2, 4-triazole (5d), 4-Amino- 5-mercapto- 3-(4-methoxyophenyl)-1, 2, 4-triazole (6d) were synthesized according to the literature methods. The synthesized comp 1,2,4-triazole, anticancer activity, tumor cell count, tumor weight inhibition https://www.ijper.org/article/46/4/303-311 2026-04-13T05:55:45.405739+00:00 Design and Development of Ciclopirox Topical Nanoemulsion Gel for the Treatment of Subungual Onychomycosis 2012-12-31 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-4-303.pdf Onychomycosis is the most common infection of nails caused majorly by Trichophyton rubrum and Trichophyton mentagrophytes and minorly by yeasts. Topical delivery of available ciclopirox formulations as nail lacquer, cream, lotion, gel is hindered by the low permeability of human nail plates, and so there is need of repeated dosing for a longer period of time for effective treatment. In the present research work an attempt is made for effective delivery of ciclopirox olamine (CIC) across human na Onychomycosis, Nanoemulsion, permeation, fluorescent microscopy, thermodynamic stability https://www.ijper.org/article/46/4/366-371 2026-04-13T05:55:45.405739+00:00 Molecular Properties Prediction, Synthesis and Bio-evaluation of Triazines glued Benzothiazole congeners 2012-12-31 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-4-366.pdf In the current investigation, some newer triazines merged benzothiazole hybrids were subjected to molecular properties prediction, drug-likeness, lipophilicity and solubility parameters determination using Molinspiration, Molsoft and ALOGPS 2.1 softwares. Amongst ten proposed analogues only seven therapeutic candidates were chosen on the basis of Lipinski’s “Rule of Five”. Selected title compounds were synthesized by cyclizing 3-chloroaniline and potassium thiocyanate in presence of bromine yiel Diplocyclos palmatus, Seeds, Streptozotocin, Diabetes https://www.ijper.org/article/46/4/296-302 2026-04-13T05:55:45.405739+00:00 Preparation and Evaluation of Freeze Dried Crystals of Ketoprofen using Lyophilization Monophase Solution Technique for Direct Compression Tablets 2012-12-31 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-4-296.pdf Ketoprofen, an anti-inflammatory drug, exhibits poor water solubility, dissolution and flow properties. Thus, the aim of the present study was to improve the solubility and dissolution rate of Ketoprofen by preparing crystals by freeze drying technique. Ketoprofen crystals were prepared by freeze drying using Isopropyl alcohol (IPA), chloroform and water as monophasic solvents system to enhance solubility and dissolution rate. The prepared crystals of Ketoprofen were evaluated for IPA and chloro Ketoprofen, Freeze drying, compressibility, Solubility, Dissolution, Stability https://www.ijper.org/article/46/4/330-339 2026-04-13T05:55:45.405739+00:00 Design and Evaluation of a Sustained Release Enteric Coated Dosage Form of Fluoxetine Hydrochloride 2012-12-31 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-4-330.pdf The purpose of present study was to develop once a day sustain release enteric coated tablet of Fluoxetine HCl by direct compression method. Design was prepared for nine batch using fenugreek mucilage at 40%, 50% and 60% concentration ; HPMC at 10%, 15% and 20%; compritol ATO 888 at 10%, 15% and 20% and ethyl cellulose at 2%, 3% and 4% concentration. Fenugreek mucilage was extracted from dried ripe seeds of Trigonella foenum-graecum (Fabaceae). Cellulose acetate phthalate was used as enteric coa Delayed release, Fluoxetine HCl, HPMC K 100M, Fenugreek mucilage https://www.ijper.org/article/46/3/248-252 2026-04-13T05:55:46.139599+00:00 lonotropically Gelled Chitosan-alginate Complex Hydrogel Beads: Preparation, Characterization and In-vitro Evaluation 2012-07-18 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-3-248.pdf Prolonged release drug delivery system of stavudine was made by ionotropic gelation and polyelectrolyte complexation technique. Cross-linking reinforced chitosan-Alginate complex beads were prepared by gelation of anionic sodium alginate, the primary polymer, with oppositely charged counter ion to form beads which were further complexed with chitosan as a polyelectrolyte. The effect of this polymer on release profile of drug was studied. Beads without chitosan complexation were also made. The re Stavudine, sodium alginate, chitosan, ionotropic gelation https://www.ijper.org/article/46/3/235-242 2026-04-13T05:55:46.139599+00:00 Carbopol and Sodium Carboxymethylcellulose Based Methylsulfonylmethane Gels for Treatment of Osteoarthritis: In-vitro and In-vivo Evaluation 2012-07-18 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-3-235.pdf The objective of present study was to prepare transdermal gels of methylsulfonylmethane (MSM) alone or in combination with aloe vera and sesame oil using polymers like carbopol 940 (CP) and sodium carboxymethylcellulose (NaCMC). The physicochemical compatibility of drug and the polymers was confirmed by infrared spectroscopy and differential scanning calorimetry. The gels were evaluated for various physicochemical parameters such as pH, homogeneity, spreadability, viscosity measurement and drug Methylsulfonylmethane, Transdermal gel, Osteoarthritis, Aloe vera, Sesame oil https://www.ijper.org/article/46/3/265-269 2026-04-13T05:55:46.139599+00:00 Design and In-vitro Characterization of Levobunolol Hydrochloride Occuserts with Special Reference to Glaucoma Treatment 2012-07-18 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-3-265.pdf The aim of present study was to design and in-vitro characterization of Levobunolol HCl occuserts with special reference to glaucoma treatment. Levobunolol HCl ophthalmic solution has been shown to be effective in IOP and may be used in patients with chronic open-angle glaucoma or ocular hypertension. The Levobunolol HCl occuserts were prepared using hydroxypropyl methylcellulose (HPMC, 3 & 4%), poly vinyl pyrrolidone (PVP, 1%), methyl cellulose (MC, 1 & 2%) as polymers by solvent casting techni Levobunolol HCl, Occusert, Glaucoma, In-vitro characterization https://www.ijper.org/article/46/3/197-205 2026-04-13T05:55:46.139599+00:00 Estimation of Stavudine, Lamivudine and Nevirapine by Chemometric UV Spectroscopic Method 2012-07-18 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-3-197.pdf A chemometric UV- spectrophotometric method of analysis was successfully developed for the simultaneous determination of stavudine, lamivudine and nevirapine in pharmaceutical formulation. The application of multivariate method to the obtained spectrophotometric data is a new idea for the simultaneous quantitative analysis of stavudine, lamivudine and nevirapine in samples. Multivariate calibration models were built from the raw PLS(Partial least square) method. Verification of the calibration c Antiretrovirals, chemometric, UV spectroscopy, stavudine, lamivudine, nevirapine https://www.ijper.org/article/46/3/283-289 2026-04-13T05:55:46.139599+00:00 Multiple - Unit Floating Drug Delivery System for Gastric Retention of Weakly Acidic Drug 2012-07-18 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-3-283.pdf The objective of the work is to develop a multiple-unit-type of oral floating drug delivery system to prolong the gastric residence time and increase the bioavailability of weakly acidic drugs, which has absorption window in the gastric region. Floating alginate beads were formulated using Glipizide, an oral antidiabetic drug as a model. The beads were prepared by dispersing Glipizide with various gas forming agent (Calcium Carbonate, Magnesium Carbonate, Sodium Bicarbonate, Sodium Carbonate, Po Glipizide, Floating Beads, Gas forming agents, Multiple-unit Floating Drug Delivery System https://www.ijper.org/article/46/3/217-221 2026-04-13T05:55:46.139599+00:00 16S rDNA sequencing of Antibiotic Producing Bacterial Strain Lysinibacillus sp.(BP-3) from Nagavali River Basin of Srikakulam. 2012-07-18 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-3-217.pdf Antibiotic producing bacteria Lysinibacillus sp.(BP-3) was isolated from the Nagavali river basin, Srikakulam, Andhra pradesh, India. The whole cell protein extract of BP-3 strain was found to have significant inhibitory effect on the test strains viz: E.coli (MTCC 40), Staphlococcus aureus (MTCC87),Proteus vulgaris(MTCC426), and Pseudomonas aeruginosa (MTCC 424). Identification of the bacteria was carried out using biochemical tests, 16SrRNA sequencing and sequences submitted to the NCBI GenBan Nagavali, antibiotic, 16SrRNA sequencing, Lysinibacillus https://www.ijper.org/article/46/3/275-282 2026-04-13T05:55:46.139599+00:00 Application of the experimental design method to photostability studies of Karvileks tablet 2012-07-18 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-3-275.pdf This study was examined a photostability of Karvileks (Zdravlje-Actavis, Serbia), packed in the different primary packs. For these examination, the experimental design with 3 independent variables: wavelength of radiation (X1), duration of radiation (X2) and type of packs (X3) was applied. After irradiation of Karvileks, the content of carvedilol and its impurities A, B and C was taken as a response (Y1, Y2, Y3, Y4). The obtained mathematical equations can be used for determination of carvedilol experimental, design, photostability, Karvileks https://www.ijper.org/article/46/3/222-227 2026-04-13T05:55:46.139599+00:00 Evaluation of Anti-ulcer Activity of Stem Bark Extract of Aphanmixis Polystachya in Experimental Rats 2012-07-18 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-3-222.pdf Aphanmixis polystachya (Amoora rohituka) is well known traditional plant in India. The plant is having laxative, anthelmintic, astringent, Immunosuppressive, potent antitumor activity and in-vitro antibacterial, antifungal activity. The aim was to search for anti-ulcer activity of aqueous and methanolic extract of Aphanmixis polystachya stem bark. Aqueous and methanolic extract of Aphanmixis polystachya stem bark was investigated for its potential to protect gastric mucosa against ulcers induced Antiulcer activity, Aphanmixis polystachya, Ulcer index https://www.ijper.org/article/46/3/270-274 2026-04-13T05:55:46.139599+00:00 Gel Based lontophoretic Delivery System for Enhanced Transdermal Permeation of Alendronate Sodium 2012-07-18 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-3-270.pdf The purpose of the present study was to explore the passive and electrically assisted transdermal transport of Alendronate Sodium (AS) by iontophoresis in combination with penetration enhacers. For better bioavailability, better patient compliance, and prevention of gastro-intestinal irritation of AS, an iontophoretic drug delivery system of AS gel was formulated using Carbopol-940. Optimization of gel indicated the suitability of the Carbopol gel for transdermal iontophoretic delivery of AS. Th Alendronate Sodium, Iontophoresis, Carbopol gel https://www.ijper.org/article/46/3/253-258 2026-04-13T05:55:46.139599+00:00 Novel Approach in Designing Mouth Dissolving Tablets of Cetirizine Hydrochloride 2012-07-18 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-3-253.pdf The present work was to design and evaluation of mouth dissolving tablets of Cetirizine hydrochloride by using superdisintegrants. A novel approach has been made to develop Cetirizine hydrochloride mouth dissolving tablets by including clove oil as flavor and local anesthetic on taste buds. The drug and excipients were characterized using Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared (FTIR) techniques. The drug excipient blend was evaluated for examined physicochemical p Mouth dissolving tablet, Cetirizine hydrochloride, Clove oil, superdisintegrants https://www.ijper.org/article/46/3/259-264 2026-04-13T05:55:46.139599+00:00 Formulation and Evaluation of Bilayer Floating Tablets of Trimetazidine hydrochloride and Metoprolol succinate 2012-07-18 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-3-259.pdf The objective of the present investigation was to develop bilayer floating tablets of Trimetazidine hydrochloride and Metoprolol succinate for stable angina pectoris insufficiently controlled by monotherapy with beta-blocker. Bilayer floating tablets was formulated using wet granulation technique and it consists of two layers, i.e. immediate release layer containing Metoprolol succinate and floating sustained release layer containing Trimetazidine hydrochloride. The immediate release layer compr Bilayer floating tablet, Trimetazidine hydrochloride, Metoprolol succinate, angina pectoris https://www.ijper.org/article/46/3/228-234 2026-04-13T05:55:46.139599+00:00 A Comparative Study of Polyphenolic Composition and In-vitro Antioxidant Activity of Illicium verum Extracted by Microwave and Soxhlet Extraction Techniques 2012-07-18 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-3-228.pdf Star anise (Illicium verum) was extracted with ethanol using microwave - assisted extraction and soxhlet extraction. Total phenolic content of microwave – assisted extract (MSA) and conventional extract of star anise (SSA) reached 271.2 mg/g and 289 mg/g dry weight, respectively, expressed as gallic acid equivalents, which were quantified using Folin–Ciocalteau reagent. Subsequently, total flavonoids content of MSA and SSA extracts were found to be 14.64 mg/g and 13.98 mg/g dry weight, respectiv Illicium verum, microwave assisted extract, antioxidant activity, total flavonoids content, total phenolic content https://www.ijper.org/article/46/3/211-216 2026-04-13T05:55:46.139599+00:00 Characterization of Moringa oleifera Lam. Gum to Establish it as a Pharmaceutical Excipient 2012-07-18 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-3-211.pdf The gums are common constituents of plants which have been ignored by pharmacists of the modern day. Moringa oleifera gum was identified to be useful in colon targeted drug delivery. This study elucidates the physical and pharmacological properties of Moringa oleifera gum in order to establish it as a pharmaceutical excipient. The parameters applied for the present study include solubility, total ash and acid insoluble ash value, moisture content, pH value, angle of repose, swelling index, bulk Moringa oleifera, gum, excipent, physiochemical, toxicity https://www.ijper.org/article/46/3/206-210 2026-04-13T05:55:46.139599+00:00 Synthesis and Pharmacological Evaluation of New 4-Aryl-3,4,5,6,7,8- hexahydroquinazolin-2(1H)-thiones 2012-07-18 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-3-206.pdf New 4-aryl substituted quinazolin-2-thiones were synthesized and confirmed by spectral studies like IR and NMR. Then screened for antimicrobial, analgesic, anti-inflammatory and CNS depressant activities. All the derivatives were showing the pharmacological activity mainly due to the presence of basic nucleus, quinazolin-2-thione and was modified with various substituents at 4th position with different aryl substituents. Among all the substituents, the halogen substituted compounds are comparati Quinazolinones, cyclohexanone, chalcones, Aldol condensation, cylization https://www.ijper.org/article/46/3/243-247 2026-04-13T05:55:46.139599+00:00 Evaluation of Effect of Shodhana Treatment on Pharmacological Activities of Aconite 2012-07-18 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-3-243.pdf The lethal plant origin cardiac and neuro-muscular poison ‘aconite’ is used as a therapeutic agent for the treatment of fever, arthritis, in Ayurvedic system of medicine after Shodhana treatment. The present study was designed to evaluate likely impact of Shodhana treatment on cardiac activity, antipyretic activity and neuro-muscular activity of aconite. Pharmacological activities of raw aconite (RV), treated aconite in cow’s urine (SM) and treated aconite in cow’s milk (SD) were evaluated and c Aconite, antipyretic, cardiac, neuro-muscular https://www.ijper.org/article/46/3/290-295 2026-04-13T05:55:46.139599+00:00 An Analysis of Adequacy of Indian Drugs Regulatory Provisions in Combating the Problem of Spurious and Adulterated Drugs 2012-07-18 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-3-290.pdf In 2003, Mashelkar committee found that 10% of available drugs in India are Sub- standard. Recently (June 2011) Honorable Apex Court of India observed that the Drugs Act of India does not has deterrence. It has to be analyzed that whether mere enhancing the punishment under the Act shall make it deterrent. It has to be find out what other changes in the Act is required to make it more effective. Drugs Control Authorities need power of interrogation and power to ask a person to make statement. Th Glipizide, Floating Beads, Gas forming agents, Multiple-unit Floating Drug Delivery System https://www.ijper.org/article/46/2/168-173 2026-04-13T05:55:46.947224+00:00 Bronchoprotective, Bronchodilatory and Anti-Inflammatory Activity of Ethanolic Extract from Woodfordia fruticosa (Kurz.) Flowers 2012-04-14 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-2-168.pdf The present investigation was aimed to investigate the bronchoprotective, bronchodilatory and anti-inflammatory effect of ethanol extract of Woodfordia fruticosa dried flower (WF-EE). WF-EE exhibited significant and dose dependent bronchoprotective, bronchodilatory and antiinflammatory effect. WF-EE at 200 mg/kg prolonged the latent period and exhibited protection against experimental asthma induced by the combination of histamine and acetylcholine aerosol in guinea pigs. WF-EE (1 mg/ml) exhibit Woodfordia fruticosa, asthma, bronchodilation, guinea pig trachea, anti-inflammatory, carrageenan, egg-albumin https://www.ijper.org/article/46/2/174-178 2026-04-13T05:55:46.947224+00:00 In-vitro Antibacterial Screening of Selected Folklore Indian Medicinal Plants with few Clinical Pathogens 2012-04-14 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-2-174.pdf Antibacterial activities of 7 plant extracts were evaluated against 5 bacterial strains using well diffusion assay at different concentration (10%, 20% and 30%) and the results were compared with therapeutically used antibiotics. Rapid formation of inhibition zones within 24 hours of incubation was obtained with ethanolic extracts (30%) of Justicia gendarussa against all tested strains. Ethanol extracts (30%) of the Gymnema sylvestre produces a maximum inhibition zone of 24mm against Pseudomonas Antibacterial activity, plant extracts, inhibition zone, cluster analysis https://www.ijper.org/article/46/2/145-154 2026-04-13T05:55:46.947224+00:00 Development and Statistical Optimization of Buccoadhesive Films of Amiloride Hydrochloride: In-vitro and Ex-vivo Evaluation 2012-04-14 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-2-145.pdf The aim of present investigation was to develop an optimized buccoadhesive film of Amiloride hydrochloride (AMHCl), a BCS class III drug, to provide unidirectional sustained drug delivery to the buccal mucosa that has potential to enhance the bioavailability. The films were prepared using HPMC K4M as film former, carbopol 934P as buccoadhesive polymer and dimethyl sulfoxide as penetration enhancer, by solvent casting technique. The films were characterized for various pharmacotechnical parameter Amiloride hydrochloride, 23full factorial design, buccoadhesive film, optimization, pareto charts, response surface plots https://www.ijper.org/article/46/2/137-144 2026-04-13T05:55:46.947224+00:00 Formulation Design and Characterization of Kollidon SR Based Trimetazidine Dihydrochloride Matrix Tablets 2012-04-14 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-2-137.pdf The purpose of the present study was to formulate sustained release Trimetazidine Dihydrochloride matrix tablets by using Kollidon SR as rate controlling polymer. Each of the formulated tablet contains 35 mg of Trimetazidine Dihydrochloride. The tablets were prepared by direct compression method. The granules were evaluated for angle of repose, bulk density, tapped density and compressibility index. The formulated tablets were evaluated for weight variation, thickness, diameter, hardness, friabi Trimetazidine Dihydrochloride, Kollidon SR, Matrix Tablet https://www.ijper.org/article/46/2/129-136 2026-04-13T05:55:46.947224+00:00 Synergistic Homopolysaccharide:Heteropolysaccharide Interactions-Rheological Investigation and Development of Sustained Release Tablets 2012-04-14 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-2-129.pdf Polymers used in combinations, the net effect produced by them is much greater than that given when used alone. Pronounced synergistic interactions have been observed when homopolysaccharide (galactomannan) and heteropolysaccharide, xanthan gum (XG) used together. Polymers from galactomannan category like guar gum (GG) and locust bean gum (LBG) and heteropolysaccharide were evaluated for optimum viscosity synergism. Viscosity studies of aqueous solutions of individual polymers and their combinat Erosion, Galactomannan, Heteropolysaccharide, Homopolysaccharide, Swelling, Viscosity synergy https://www.ijper.org/article/46/2/155-160 2026-04-13T05:55:46.947224+00:00 Utilization of Natural Olibanum Gum Resin as a Rate Controlling Polymer in Design and Evaluation of Microspheres of an Antiretroviral Drug by using a Unique Spray Drying Technique 2012-04-14 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-2-155.pdf Olibanum gum resin was evaluated as rate controlling agent and to prepare resin-coated microspheres. Zidovudine (AZT), an anti-retroviral drug was selected as novel drug for the experiment. Resin coated microspheres of AZT were prepared by spray drying technique using olibanum gum resin as a rate controlling polymer and the microspheres were evaluated. The resin-coated microspheres were spherical, discrete, free flowing and multinucleate monolithic type. The mean size range was found for formula Olibanum gum resin, spray drying, non-fickian diffusion, controlled release https://www.ijper.org/article/46/2/179-184 2026-04-13T05:55:46.947224+00:00 Synthesis and In-vivo Anti-convulsant Activity of Prodrug of 3-Alkylglutamic Acid in Albino Rats 2012-04-14 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-2-179.pdf 3-Alkyl glutamic acid decrease excitation and glutamate in brain. 3-Alkyl glutamic acid analogues displayed glutamic acid decarboxylase activation activity and anticonvulsant activity. We herein are reporting the result of our studies on the synthesis and evaluation of anticonvulsant activity for prodrug of 3-Alkyl Glutamic Acid. Prodrugs of Glutamic Acid were synthesized by taking the Dihydropyridine compound as carrier molecules and were subjected to preliminary screening for anticonvulsant ac Prodrug, 3-Alkyl Glutamic acid, Anticonvulsant, Phenytoin sodium, Dihydropyridine https://www.ijper.org/article/46/2/120-128 2026-04-13T05:55:46.947224+00:00 Development and Evaluation of Mucoadhesive Algino-HPMC Microparticulate System of Aceclofenac for Oral Sustained Drug Delivery 2012-04-14 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-2-120.pdf Micro-particulate drug delivery of aceclofenac was prepared by ion gelation technique using a blend of sodium alginate and HPMC as release retardant. The gastric residence of conventional dosage form is typically short which transit rapidly through the small intestine in not more than 3h, thus rapid gastrointestinal (GI) transit phenomenon may consequently lead to reduction in the extent of absorption of various drugs. The present study was to develop mucoadhesive microsphere of aceclofenac and Non Steroidal Anti Inflammatory Drugs, Gastrointestinal Tract, Hydroxy propyl Methyl Cellulose, International Conference of Harmonization https://www.ijper.org/article/46/2/185-191 2026-04-13T05:55:46.947224+00:00 Synthesis, Characterisation and Anti-inflammatory Activity of some Novel Quinazolin-4-(3h)-one Analogues 2012-04-14 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-2-185.pdf Some new 2-[(E)-2-(substituted phenyl) ethenyl]-3-(2/4methyl phenyl) quinazolin-4(3H)-ones (Q1a-f Q2a-f have been synthesized from 3-(2- methyl phenyl) quinazolin-4(3H)-one (Q1) and 3-(4-methyl phenyl) quinazolin-4(3H)-one (Q2) by introducing different aromatic aldehydes. The synthesized compounds have been characterized by IR, 1H NMR, 13C NMR and Mass spectral techniques and screened for anti-inflammatory activity by using carrageenan induced rat paw edema method. Compounds Q1a, Q1e, Q1f and Q2 Quinazoline, Anti-inflammatory activity, Lipophilicity, Diclofenac sodium https://www.ijper.org/article/46/2/105-111 2026-04-13T05:55:46.947224+00:00 Enhanced Iontophoretic Permeation of Rizatriptan Benzoate from Thermoreversible Gel Based System: Effect of Penetration Enhancers and Pulsed Current 2012-04-14 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-2-105.pdf The purpose of present research work was to enhance the iontophoretic delivery of Rizatriptan Benzoate (RZB) through optimized gel based formulation by using chemical penetration enhancers and to study the effect of pulsed current on permeation through guinea pig, Wistar rat and human cadaver skin. Modified Franz diffusion cell was used to study the in vitro permeation across various types of skin by iontophoresis. The thermo-reversible gel was prepared and optimized by cold method using poloxam Transdermal, poloxamer, Iontophoresis, Rizatriptan https://www.ijper.org/article/46/2/97-104 2026-04-13T05:55:46.947224+00:00 Development of Aceclofenac Mouth Dissolving Tablets using Solid Dispersion Technique: In-vitro Evaluation 2012-04-14 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-2-97.pdf Formulating mouth dissolving tablet using solid dispersion of drug shall not only improve solubility and consequent bioavailability but also improved patient compliance and convenience. The aim of the present study was to improve the solubility of Aceclofenac (ACE) by solid dispersion (SD) technique and formulate it as mouth dissolving tablets using some superdisintegrants. Solid dispersion (SD) of ACE was prepared by solvent evaporation method using PEG 6000 as carrier. Different weight ratios Mouth dissolving tablets, solid dispersion, aceclofenac, polyethylene glycol 6000 https://www.ijper.org/article/46/2/161-167 2026-04-13T05:55:46.947224+00:00 Preparation of Glimepiride Sustained Release Matrix Tablets using Hibiscus rosa-sinensis Leaves Mucilage and Povidone 2012-04-14 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-2-161.pdf The main purpose of the present work was to develop matrix tablets of Glimepiride with Hibiscus rosa-sinensis leaves mucilage and Povidone and to study its functionality as a matrix forming agent for sustained release tablet formulations. Mucilage from Hibiscus rosa-sinensis leaves was extracted, isolated, purified and characterized. Physicochemical properties of the dried powdered mucilage of Hibiscus rosa-sinensis leaves were studied. Various formulations of Glimepiride Hibiscus rosa-sinensis Glimepiride, Hibiscus rosa-sinensis, Povidone, matrix tablets, sustained release https://www.ijper.org/article/46/2/112-119 2026-04-13T05:55:46.947224+00:00 Formulation and In-vitro Evaluation for Sun Protection Factor of Crinum asiaticum Linn flower (Family-Amaryllidaceae) Extract Sunscreen Creams 2012-04-14 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-2-112.pdf Crinum asiaticum Linn. flowers commonly known as white lily flowers were explored to find flavonoids, so, thin layer chromatography was performed and some of the flavonoids were identified as flavon (Apigenine ), flavonol (Quercetin), flavan-3-ols (Catechin), isoflavones (Daidzein). flavonol (Fisetin, Myricetin and Kaempferol). The reported flavonoids were known to have sunscreen activity and hence SPF factor of the dried flower extract (aqueous) was incorporated in topical formulation and evalu Sun Protection Factor, in vitro method, flavonoids, Crinum asiaticum L. (Amaryllidaceae) flowers https://www.ijper.org/article/46/2/88-96 2026-04-13T05:55:46.947224+00:00 Lipid Based Self Emulsifying Formulations for Poorly Water Soluble Drugs-An Excellent Opportunity 2012-04-14 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-2-88.pdf Currently more than 50% of compounds identified are water insoluble and or poorly water soluble. These molecules are difficult to formulate using conventional approaches (for their poor aqueous solubility) and are associated with numerous formulation-related performance issues. Formulating these compounds using lipid based systems is one of the growing interest and suitable drug delivery strategies are applied to this class of molecules. The rapid growth and investment in the use of lipid based Self-emulsifying formulations, oral drug delivery, solvent capacity, drug precipitation, LFCS https://www.ijper.org/article/46/2/192-196 2026-04-13T05:55:46.947224+00:00 Formulation and In-vitro Evaluation of Zidovudine-Lamivudine Nanoparticles 2012-04-14 10.5530/xxxxxxxxx https://jourdata.s3.us-west-2.amazonaws.com/ijper/IndJPharmEduRes-46-2-192.pdf Human Immunodeficiency Virus infection and Acquired Immune Deficiency Syndrome commonly referred to as HIV/AIDS which have emerged as being the most serious and challenging public health problems in the world. Zidovudine-Lamivudine nanoparticles were prepared by emulsion polymerization in a continuous aqueous phase with different polymers poly(lactic-co-glycolic acid) PLGA (50:50), Poly(lactic acid) PLA, Poly (methyl methacrylate) PMMA, Methylmethacrylate-Sulfopropylmethacrylate (MMA-SPM). The HIV, Nanoparticles, Emulsion Polymerization method, In vitro release, Stability study