Home | Articles
Published on:August 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(3s):s332-s337
Original Article | doi:10.5530/ijper.53.3s.103

In silico Docking Analysis of Active Biomolecules from Cissus quadrangularis L. against PPARG

Authors and affiliation (s):

Vishal Shivalingappa Patil, Prakash Rajashekhar Biradar, Vasim Attar, Pukar Khanal*

Department of Pharmacology, KLE College of Pharmacy, KAHER, Belagavi, Karnataka, INDIA.


Introduction: Thiazolidinedione’s are widely used synthetic antidiabetic agents. These agents affect the pumping power of heart muscle due to the formation of edema; limiting their usage in patients with congestive heart failure. The current study was aimed to perform in silico docking study of bioactive phytoconstituents from Cissus quadrangularis Linn. against the target Peroxisome proliferator-activated gamma (PPAR-γ). Materials and Methods: The docking study was performed by using AutoDock 4.2. The chemical constituents were retrieved from the PubChem database. The pharmacokinetic and toxicological parameters of each compound were predicted using PreADMET online server. The drug-likeness character of each compounds were predicted using Molsoft. Results: Quercetin scored highest drug-likeness character. Among the seven compounds, four compounds scored positive drug-likeness score. Qaudrangularin A showed highest binding affinity with the target protein. Discussion: All the compounds showed the binding affinity with the target protein suggesting that the compounds from Cissus quadrangularis can be utilized to target PPAR-γ in the management of diabetes. The study suggests supporting the current study by performing wet lab experiments.

Key words: Cissus quadrangularis, Diabetes Mellitus, Lipinski rule of five, Molecular Docking, PPAR-γ.



Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).


Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs