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Published on:February 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(2):261-267
Original Article | doi:10.5530/ijper.53.2.34

Alcohol Extract of Wattakaka volubilis (L.F) Stapf Root Inhibits Aldose Reductase to Prevent Diabetes Associated Cataract Formation in Rats


Authors and affiliation (s):

Hajira Banu Haroon, Anita Murali*

Department of Pharmacology, Faculty of Pharmacy, M. S. Ramaiah University of Applied Sciences, MSRIT Post, MSR Nagar, Bangalore- 560054, Karnataka, INDIA.

Abstract:

Aim: The aim of this study was to investigate the aldose reductase inhibition and anti-cataract property of W. volubilis root extract in rats with streptozotocin induced diabetes mellitus. Methods: Diabetes was induced by a single intraperitoneal injection of streptozotocin at the dose of 45 mg/kg. Diabetic animals were treated with glimepiride (0.5 mg/kg) and alcohol extract at 100 and 200 mg/kg for 38 d. Lens were isolated and certain markers were estimated. Results: Treatment of diabetic animals with alcohol extract of W. volubilis root inhibited aldose reductase activity (p < 0.001) and sorbitol formation in the lens. Additionally, a reduction in the levels of MDA, GSH, SDH and LDH in extract treated groups was observed. There was an overall decrease in the severity of cataract progression. Conclusion: The result provided evidence that alcohol extract of W. volubilis root prevents the development of diabetic cataract in rats.

Key words: Wattakaka volubilis, Diabetes mellitus, Cataract, Aldose reductase, Polyol pathway.

 

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IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs