Formulation and Evaluation of Chitosan Based Transdermal Patches of Lornoxicam for Prolonged Drug Release and To Study the Effect of Permeation Enhancer

Abstract:

Objective: The objectives of present investigation were to develop transdermal system for Lornoxicam using chitosan as rate controlling polymer and Tween 20 as permeation enhancer. Then evaluate the effect of Tween 20 on the physico-chemical properties of the patches and on drug permeation across the membrane. Methods: Transdermal patches of Lornoxicam were prepared by solvent casting method. The prepared patches were evaluated for physicochemical characteristics such as in vitro drug release, skin irritation studies. The interaction between drug and polymer were investigated by FTIR, DSC, XRPD methods. Results: The in vitro release studies revealed Formulation L4 containing higher concentration of Tween 20 showed 74.6 % diffusion in 12 h and follows Korsmeyer-Peppas drug release kinetics. Respective formulation did not showed any sign of erythema or edema in skin irritation test. FTIR study reveals good compatibility between drug and polymer. Conclusion: The prepared transdermal drug delivery system of Lornoxicam using Chitosan had shown good promising results for sustained release matrix transdermal patch formulation.

Key words: Transdermal patches, Chitosan, Lornoxicam,Tween 20, In-vitro release studies.