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Published on:20 sep 2013
Indian Journal Of Pharmaceutical Education & Research, 2013; 47(2):183-187
Research Article | doi:

Simultaneous Estimation of Anions Present in Oral Rehydration Salt by ION Chromatography and its Method Validation


Authors and affiliation (s):

Preeti Kulkarni1, Sonal Desai1, Pratima Tatke1*, T. P. Ghule2, C.D. Chavan2 and V. R. Bhate2
1C. U. Shah College Of Pharmacy, S. N. D. T. Women's University, Santacruz (W), Mumbai-400 049, India.
2Analytical Solutions, R-610, Rabale, M. I. D. C., Mumbai-400 701, India.

 

Abstract:

The present study aims at development of method for simultaneous estimation of chloride and citrate in oral rehydration salt (ORS) by ion chromatography and its validation. The estimation was carried out with a step change gradient mode by altering concentrations of NaOH as an eluent, an anion exchange column IonPac AS11 analytical column, guard column AG11 and conductivity detector. The suppressor used was used as ASRS ULTRA. The developed method was validated as per ICH guidelines for various parameters. The method is useful for determining the contents of chloride and citrate in single run from ORS.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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