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Published on:20 sep 2013
Indian Journal Of Pharmaceutical Education & Research, 2013; 47(2):129-134
Research Article | doi:Not Applicable

In Silico Antigenicity Screening of Moringa Coagulant


Authors and affiliation (s):

Namdeo Jadhav*1, Badrinath Bhawale1, Santosh Bhende1, Sushilkumar Patil2 and Kailas Sonawane3
1Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, India.
2Pharmacy Group, Birla Institute of Technology and Science, Pilani, Rajasthan.
3Department of Bioinformatics and Microbiology, Shivaji University, Kolhapur- 416013, Maharashtra, India.

Abstract:

Moringa coagulant (MC) obtained from the seeds of plant moringa oleifera (family- Moringaceae) has been substantially investigated for water purification, but, scarcely pharmaceutical applications. Recent investigations state its utility in dissolution enhancement of poorly soluble drugs, amorphous state stabilization and extended drug release. To broaden the applications of MC as a pharmaceutical excipient, need has been felt to test its antigenicity owing to its proteinic nature. In silico antigenicity screening has been carried out to enable its use in formulation of both parenteral and oral dosage form. Virtual screening carried out using online servers (ProtScale Analysis, BcePred, ABCPred, HLA-DR4Pred) predicted the probable antigenic epitopes of MC using hydrophobicity, hydrophilicity, exposed surface, secondary structure, antigenic propensity scale etc. Using these servers, the most probable antigenic regions in MC were observed to be 2-10, 29-34 and 47-53. The studies demonstrate that, MC may not pose difficulty in formulation of nonparenteral dosage forms, but, if intended for parenteral delivery, its antigenic domain needs to be exhaustively investigated.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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