A Research Article on Nanogel as Topical Promising Drug Delivery for Diclofenac sodium

Abstract:

Background: Transdermal delivery of drug is promising but challenging system is available for local as well as systemic effect of drug. The prolonged residence of drug formulation in the skin is important for transdermal drug delivery. Objective: The objective of the present investigation was to develop a nanogel with reduced particle size in order to improve the bioavailability of the anti-inflammatory drug, Diclofenac sodium. Methods: The present study is to formulate nanosizes dispersion of diclofenac sodium by emulsionsolvent diffusion method and incorporation of gelling agent to produce nanogel. The formulation are characterized for particle size ranging from 100-400 nm. A drug named diclofenac sodium used in rheumatoid disorders and chronic inflammatory diseases. Results: Glycerol: Water (20:80) co-solvent system is selected for preparing diclofenac sodium nanogels using different polymers and has better permeability coefficient than alcohol: water co-solvent. Permeation through cellophane membrane was carried using 0.9% w/v sodium chloride using receptor fluid in franz diffusion cell (1.74 cm₂). Gels containing diclofenac sodium with eudragit polymer shown better permeability coefficient. Conclusion: Diclofenac sodium nanogels formulated using carbopol with permeation enhancer has shown better flux enhancement in comparison with nanogels formulated using HPMC and methyl cellulose. It has been concluded that diclofenac sodium nanogels using carbopol 940 as gelling agent and Eudragit S-100 has shown better flux enhancement with propylene glycol as permeation enhancer.

Key words: Diclofenac sodium, TDDS, Eudragit S-100, Glycerol, Carbopol-940, Cellophane membrane.