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Published on:December 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(4s):s722-s728
Original Article | doi:10.5530/ijper.51.4s.104

Comparative Study of Various Non-Nucleoside Reverse Transcriptase Inhibitors on Different Reverse Transcriptase Enzyme


Authors and affiliation (s):

Shital Manoj Patil*, Kalyani Dhirendra Asgaonkar, Trupti Sameer Chitre, Aditi Kinikar, Chaitali Kharat, Vaibhavi Bhoirekar, Madhura Athavale, Mitali Katkar

Department of Pharmaceutical chemistry, All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy, Pune, INDIA.

Abstract:

Context: Acquired immunodeficiency Syndrome (AIDS) is caused by Human immunodeficiency virus type 1 (HIV-1). 4-Thiazolidone nulecus is the target pharmacophore which have diverse biological activities including anti HIV activity. Aim: To study binding behavior of thiazolidinone derivatives on four different crystal structures of HIV- 1RT. Material and Method: Binding pattern of some thiazolidinone derivatives was gauged by molecular docking studies on four different receptors bearing PDB code 1ZD1, 1RT2, 1KLM, 1FKP of HIV–RT enzyme using V. Life MDS software. Result and Discussion: The studies revealed hydrogen bonds, hydrophobic interaction and pi-pi interactions playing significant role in binding of the molecules to the enzyme. Conclusion: Interactions, binding energy and dock score of molecule 6 was comparable with the standard drugs.

Key words: Molecular Docking, Thiazolidinone, HIV, NNRTI.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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