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Published on:September 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(3s2):s493-s497
Original Article | doi:10.5530/ijper.51.3s.73

Potential of Alternanthera philoxeroides on Improvement of Anxiety-Like Behavior Induced By Ovariectomized Mice Model


Authors and affiliation (s):

Charinya Khamphukdee1, Yaowared Chulikhit2*, Supawadee Daodee2, Orawan Monthakantirat2*

1Graduate School, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, THAILAND.

2Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, THAILAND.

Abstract:

Background: Ovariectomy (OVX) causes estrogen deprivation and oxidative stress leads to the hippocampus cell death and affected on mood disorders such as anxiety. Alternanthera philoxeroides was folk used for blood tonic and neuroprotective. Objectives: The action of A. philoxeroides extract (AP) on anti-anxiety in OVX mice model was evaluated and chromatographic fingerprint of AP was analyzed. Methods: Mice were ovariectomized to induce estrogen deprivation which involved anxiety. AP (250 and 500 mg/kg/day) and 17β-estradiol (E2, 1μg/kg/day) was treated. Six weeks after treatment, anxiety-like behavior was evaluated by the elevated plus maze test (EPM) and light/ dark exploration test (LD). Additionally, fingerprint of AP was characterised by high performance liquid chromatography (HPLC) technique. Results: E2 and AP 250 and AP 500 significantly diminished the anxiety behavior. Rutin, quercetin and kaempferol were detected in this plant. Conclusion: AP can manifest anti-anxiety in mice via estrogenic activity and it may action by rutin, quercetin and kaempferol.

Key words: Alternanthera philoxeroides, Ovariectomy, Anxiety, Neuroprotective, Behavior, Flavonoids

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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