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Published on:September 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(3s2):s355-s358
Original Article | doi:10.5530/ijper.51.3s.46

The Involvement of NO–cGMP–ATP Sensitive K+ Channels Pathway in Protocatechuic Acid Peripheral Analgesia

Authors and affiliation (s):

Bektas Nurcan, Arslan Rana

Anadolu University Faculty of Pharmacy Department of Pharmacology Eskisehir, 26470, TURKEY.


Protocatechuic acid (PCA) is a widely distributed natural bioactive phenolic acid. The various pharmacological activities such as antioxidant, antidiabetic and anti-inflammatory activities have been identified. However, the studies focused on the analgesic effect of protocatechuic acid are limited and the action mechanisms of PCA still remain unclear. The NO-cGMP-ATP-sensitive K+ channels pathway is one of the mechanism of action for various analgesic drugs. The present study was conducted to investigate the involvement of NO–cGMP–ATP sensitive K+ channels pathway in analgesic effect of p.o. administration of 300 mg/kg protocatechuic acid in acetic acid-induced writhing test in mice. It was shown that pre-treatment with glibenclamide (10 mg/kg, i.p.), an ATPsensitive K+ channel blocker, and methylene blue (20 mg/kg, i.p.), a guanylate cyclase inhibitor, did not notably change antinociception produced by 300 mg/kg protocatechuic acid, however administration of nitro-L-arginine methyl ester (10 mg/kg, i.p.), a nitric oxide synthase inhibitor, significantly reversed protocatechuic acid antinociception. The results show that the peripheral mechanism of action of protocatechuic acid-induced antinociception involved another nitric oxide related pain pathway, not NO–cGMP–ATP sensitive K+ channels pathway.

Key words: Protocatechuic Acid, Pain, No–Cgmp–Atp Sensitive K+ Channels, Writhing Test.



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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