An Evaluation of Antioxidant Potential of Flavonoid Eriodictyol in Isoproterenol-Induced Myocardial Infarction in Rats

Abstract:

Aim: The study was designed to evaluate the antioxidant potential of eriodictyol on lipid peroxidation caused due to isoproterenol induced myocardial infarction in albino male wistar rats. Methods: Myocardial Infarction was induced by subcutaneous injection of isoproterenol, 85 mg/Kg body weight after a pretreatment period of 45 days with eriodictyol in various doses 50 mg, 100 mg and 200 mg per Kg body weight through intragastric intubation. The standard drug metoprolol succinate was administered orally at a dose of 2.5 mg per Kg body weight for 45 days followed by ISO induced myocardial infarction. Results: The study showed significant increase in the levels of thiobarbituric acid reactive substances, lipid hydroperoxides and conjugated dienes both in plasma and heart tissue with considerable decrease in the levels of enzymatic and non-enzymatic antioxidants in ISO induced myocardial infracted rats. The oral administration of eriodictyol showed significant decrease in lipid peroxidation products and with significant increase in the levels of antioxidants. The cardio protective role of eriodictyol was further assessed by histopathological studies. Conclusion: The results indicate that the oral administration of metoprolol succinate also modulates the lipid peroxidation and the antioxidant status in the ISO induced myocardial infracted rats.

Key words: Myocardial infarction (MI), Isoproterenol (ISO), Eriodictyol (E), Lipid peroxidation, Antioxidants, Acute Myocardial Infarction (AMI).