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Published on:July 2017
Indian Journal of Pharmaceutical Education and Research, 2017; (4):580-587
Original Article | doi:10.5530/ijper.51.4.87

Micellar Properties and AntimicrobialActivityof a Mixed Surfactant System Constituted by Sodium Dodecyl Sulfate and Cetylpyridinium Chloride

Authors and affiliation (s):

Deniz Şahin Taş* and Servet Çete

Faculty of Sciences, Department of Chemistry, Gazi University, Ankara 06500, TURKEY.


Objective: Micellar properties of sodium dodecyl sulfate (NaDS) was examined in the presence of cetylpyridinium chloride (CPC) by means of surface tension, viscosity, dye solubilization, cloud point (CP) measurements.Antimicrobial activities of single and binary systems were also investigated. Results: A decrease in critical micelle concentration (CMC) and increase in solubilizing power for NaDS was observed with increasing CPC concentration. At the highest CPC concentration studied (0.1 M), the surface tension decreased up to 51 mN/m.Also, viscosity results showed growth in NaDS micelles (50 mM) up to the 0.1 M CPC concentration. Antimicrobial activity of NaDS, CPC and NaDS in presence of CPC was investigated against ten different strains of bacteria and ayeast which was not investigated up to now. The susceptibilities of the microorganism were determined by the agar diffusion method. The results showed that NaDS and CPC have a antimicrobial activity but NaDS in presence of CPC has not antimicrobial activity on the bacterial and yeast.

Key words: Mixed Micellization, NADS, CPC, Antimicrobial Activity.



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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