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Published on:June 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(3):490-501
Original Article | doi:10.5530/ijper.51.3.77

Synthesis, Characterization and Antimicrobial Activity of some Metal Complexes Derived from Thiazole Schiff Bases with In-vitro Cytotoxicity and DNA Cleavage Studies

Authors and affiliation (s):

Shambuling Karabasannavar1,2, Parvati Allolli3, Irfan N. Shaikh4, Basavaraj M. Kalshetty5*

1R & D centre, Bharathiar University, Coimbatore. Tamilnadu, INDIA.

2Department of Chemistry, BGMIT Mudhol, Karnataka, INDIA.

3Department of Pharmaceutical chemistry, Karnataka State Women University, Bijapur. Karnataka, INDIA.

4Department of Chemistry, SECAB Institute of Engineering & Technology, Vijayapur, Karnataka, INDIA.

5Department of chemistry, BLDE’s Science College Jamkhandi, Bagalkoti, Karnataka, INDIA.


Five metal complexes with Schiff-base ligand, 3-((4-phenylthiazol-2-ylimino) methyl)-2- hydroxybenzoic acid were synthesized with metal ions such as Cu(II), Co(II), Ni(II), Cd(II) and Zn(II). The reaction likely proceeds via condensation of 2-amino-4-phenyl thiazole with 3-aldehydosalicylic acid and characterized by elemental analysis and various spectral studies like FT-IR, 1H NMR, ESI mass, and TGA/TDA and molar conductance studies. The spectral results revealed bidentate O-O donor and forms the complexes having square planar geometry. The antibacterial and antifungal activity of the ligand and its metal complexes was found based on the determination of minimum inhibitory concentrations. The brine shrimp biological assay was also carry out to study the In vitro cytotoxicity properties for the ligand and its metal complexes against Artemia salina. Moreover, DNA cleavage experiments revealed that the Cu (II), Co (II) and Zn (II) complexes exhibited remarkable DNA cleavage activities via the generation of hydroxyl radical.

Key words: Thiazole, Schiff base, Antimicrobial, DNA cleavage, In-vitro cytotoxicity.



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
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Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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