Solid Lipid Nanoparticles of Resveratrol: Formulation, Characterization and In vitro Anti-Inflammatory Studies

Abstract

Aim: An oral administration formulation including resveratrol and solid lipid nanoparticles is the focus of this investigation.Materials and Methods: The resveratrol SLN was prepared utilizing oleic acid as the surfactant and hydrogenated castor oil as the lipid matrix by the high-pressure homogenization process. The FTIR and DSC techniques were used to conduct the chemical as well as physical drug interaction. Using scanning electron microscopy, the physicochemical properties of SLN were examined. Using the Assay of Cyclooxygenase and 5-lipoxygenase method, resveratrol was tested for its anti-inflammatory effects in vitro. Following the in vitro anti-inflammatory trials, a stability study was conducted.Results: The optimised formulation's SLN had a spherical resveratrol and a polydispersity index of 0.371±0.042, a zeta potential of -30.9±2.6 mV, a loading capacity of 1.89±0.22%, and an encapsulation efficiency of 91.80±1.7%. It exhibited good stability at 25ºC±2ºC / 60% RH±5% RH. In addition to its anti-inflammatory effects, the resveratrol exhibited a sustained release impact.Conclusion: Based on the results of these investigations, resveratrol in an oral formulation shows promise for less frequent dosage and improved pharmacological effects.

Keywords: Resveratrol; Solid Lipid Nanoparticles; Anti-Inflammatory Activity; Sustained Release; Stability