Bio-Conjugated Metallic Complexes in Drug Design

Indian Journal of Pharmaceutical Education and Research

  • Dilend Patle1Research Scholar, Department of Pharmaceutical Science, SanjeevAgrawal Global Educational University, Bhopal-462022, Madhya Pradesh, INDIA.
  • Narendra Pratap Singh Sengar

Volume 59 Issue 1s Pages s16-s24

DOI: 10.5530/ijper.20255296

Abstract

Background: This comprehensive review highlights the importance of bio-conjugated metallic complexes in drug design, particularly in the field of metallo-pharmaceutical science. The review emphasizes the need for biological relevance and the coordination of biomolecules or modified bio-compounds with metallic systems to maximize drug action and minimize toxicity. Materials and Methods: The objective of this review is to discuss various diseases, which exemplify the potential of bio-conjugated metallic complexes as a promising approach for drug design. Results: Utilizing physiologically active ligands in metal complexes has demonstrated improved antioxidant, antiviral, antitubercular and antitumor effects. Conclusion: Bio conjugated systems have become a viable method for creating molecules with several uses that are good for human health. The development of metal-based imaging agents and drug delivery systems has increased due to the conjugation of metals with biologically active compounds.

Keywords

  • Bio-conjugation
  • Metallic complexes
  • Drug design
  • Metallo-pharmaceutical science
  • Antioxidants
  • Chelate
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