Design and Synthesis of Novel Indolizine Analogues as COX-2 Inhibitors: Computational Perspective and in vitro Screening

Chandrashekharappa Sandeep¹, Katharigatta Narayanaswamy Venugopala^2,3,*, Mohammed A. Khedr^3,4, Basavaraj Padmashali^5,6 *, Rashmi Sanganna Kulkarni⁷, Rashmi Venugopala⁸, Bharti Odhav²

¹Institute for Stem Cell Biology and Regenerative Medicine, NCBS, TIFR, GKVK, Bellary Road, Bangalore-560065, INDIA.

²Department of Biotechnology and Food Technology, Durban University of Technology, Durban 4001, SOUTH AFRICA.

³Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Kingdom of SAUDI ARABIA.

⁴Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Ein Helwan, Cairo 11795, EGYPT.

⁵Department of Chemistry, Sahyadri Science College (Autonomous), Shimoga 577 203, INDIA.

⁶Department of Studies and Research in Chemistry, School of Basic Sciences, Rani Channamma University, Belagavi 591 156, Karnataka, INDIA.

⁷Department of Chemistry, Jain University, Bangalore 560 019, INDIA.

⁸Department of Public Health Medicine, University of KwaZulu-Natal, Howard College Campus, Durban 4001, SOUTH AFRICA.