Molecular Insights into Salicylate Synthase: From Medicinal Chemistry Perspective
Indian Journal of Pharmaceutical Education and Research
Nitin Bire1Department of Pharmaceutical Chemistry, BVDU’S Poona College of Pharmacy, Erandwane Pune, Maharashtra, INDIA.
Vinayak Walhekar1Department of Pharmaceutical Chemistry, BVDU’S Poona College of Pharmacy, Erandwane Pune, Maharashtra, INDIA.
Omkar Makane1Department of Pharmaceutical Chemistry, BVDU’S Poona College of Pharmacy, Erandwane Pune, Maharashtra, INDIA.
Pranali Yelchatwar1Department of Pharmaceutical Chemistry, BVDU’S Poona College of Pharmacy, Erandwane Pune, Maharashtra, INDIA.
Amol Muthal2Department of Pharmacology, BVDU’s Poona College of Pharmacy, Paudh Road, Erandawane, Pune, Maharashtra, INDIA.
Subhash Bodhankar2Department of Pharmacology, BVDU’s Poona College of Pharmacy, Paudh Road, Erandawane, Pune, Maharashtra, INDIA.
Chandrakant Bagul1Department of Pharmaceutical Chemistry, BVDU’S Poona College of Pharmacy, Erandwane Pune, Maharashtra, INDIA.
Dileep Kumar1Department of Pharmaceutical Chemistry, BVDU’S Poona College of Pharmacy, Erandwane Pune, Maharashtra, INDIA., 5Department of Entomology, University of California, Davis, One Shields Ave, Davis, CA, USA., 6UC Davis Comprehensive Cancer Centre, University of California, Davis, One Shields Ave, Davis, CA, USA.
Baswaraju Macha3Department of Pharmaceutical Chemistry, UCPSc, Kakatiya University, Warangal, Telangana, INDIA.
Raghavendra Kulkarni4Department of Pharmaceutics, Sri Sanganabasava Mahaswamiji College of Pharmacy and Research Center, Vijayapura, Karnataka, INDIA.
Vaibhav Shinde7Department of Pharmacognosy, BVDU’s Poona College of Pharmacy, Paud Road, Erandawane, Pune, Maharashtra, INDIA.
Ravindra Kulkarni1Department of Pharmaceutical Chemistry, BVDU’S Poona College of Pharmacy, Erandwane Pune, Maharashtra, INDIA.
Tuberculosis is a pathogenic infection that has created trepidation around the globe due to its repercussion on the health of patients. The iron transport mechanism in mycobacterium plays a pivotal role in bacterial survival; whilst this can be considered an emerging drug target. Salicylate synthase is a member of the MST family and this enzyme is distrait in mammals. It is the first enzyme for the synthesis of mycobactin (siderophores) which is a determinant for iron transport. The present all-embracing review provides overall coverage of the biological and structural outlook of the enzyme salicylate synthase and its inhibitors reported in recent years. Furthermore, this review sheds limelight on the development of novel and more potent salicylate synthase inhibitors.
