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Published on:June 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(3):412-417
Original Article | doi:10.5530/ijper.51.3.69

Effects of Rutin on Testicular Antioxidant Enzymes and Lipid Peroxidation in Rats

Authors and affiliation (s):

Rahmat Ali Khan1*, Muhammad Rashid Khan2, Mushtaq Ahmed1, Mir Sadiq Shah1, Shoiab Ur Rehman1, Jahangir Khan3, Masroor Husain1, Farman Ali Khan4, Muhammad Mohibullah Khan5, Muhammad Shahzad Shifa6

1Department of Biotechnology, Faculty of Biological Sciences, University of Science and Technology Bannu, Khyber Pakutunkhwa, PAKISTAN.

2Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University Islamabad, PAKISTAN.

3Department of Pharmacy, University of Malakand, Chakdara Dir, Khyber Pakutunkhwa, PAKISTAN.

4Department of Biochemistery, Abdul Wali Khan University Mardan, 23200, Khyber Pakutunkhwa, PAKISTAN.

5Department of Plant Breeding and Genetic, PAKISTAN

6Department of Physics Government College University Faisalabad, PAKISTAN


Background: Rutin, a polyphenolic flavonoid, possesses antioxidant and hypoglycemic effects. Objective: The present study was conducted to check the effect of rutin on serum reproductive hormonal level and sperm concentration in male rat. Methods: 30 rats were equally divided into 3 groups (10 rats per group). Group I was control (untreated), group II was given rutin 50 mg/kg bw while group III was given 100 mg/ kg bw intragastric twice a week for four weeks respectively. The effect of rutin on antioxidant enzymes (POD, SOD, GSHpx, GST, GSR), glutathione contents and TBARS contents were checked. Results: The results revealed that rutin caused significant gain in body weight, antioxidant enzymes (POD, SOD, GSHpx, GST, GSR), glutathione contents, with significant (P< 0.01) decrease in thiobarbituric acid reactive substance (TBARS) concentrations. Conclusion: It may be concluded that rutin may be promising as a natural therapeutic agent in male reproductive dysfunction.

Key words: Rutin, TBARS contents, Antioxidant enzymes, Flavonoids, Catalase



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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