Isolation and Functioning Investigation of Salvia hispanica Seed Mucilage as a Potential Sustained Release Carrier for Water Soluble Drug

Indian Journal of Pharmaceutical Education and Research

  • Dibya Sundar Panda1Department of Pharmaceutics, Pharmacy College, Jouf University, Sakaka, Al-jouf, SAUDI ARABIA.
  • Madhusmruti Khandai2Departments of Pharmaceutics, Royal College of Pharmacy and Health Sciences, Berhampur, Odisha, INDIA.

Volume 57 Issue 3s Pages s724-s733

DOI: 10.5530/ijper.57.3s.82

Abstract

Background: Natural biopolymers or hydrogels are explored to sustain release of water-soluble drugs. Materials and Methods: Mucilage was isolated from Salvia hispanica seeds. Gelispheres loaded with Losartan Potassium (LP) were prepared using sodium alginate, pectin and CSM. Results: Isolated mucilage possesses immense properties like consistency and excellent hydration. Developed gelispheres exhibited good mucoadhesion and sustained drug release. Conclusion: Findings advocate the use of mucilage for twice daily losartan potassium sustain release system.

Keywords

  • Chia seed mucilage
  • Gelisphere
  • Mucoadhesion
IJOPP

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