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Published on:April 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(2s):s79-s90
Original Article | doi:10.5530/ijper.51.2s.53

Elaboration of Microspheres’ Capsules Based on Ethylcellulose and Synthesized Poly (Butylsuccinate) as Biodegradable Matrices for Drug Delivery of an Antithyroidian Agent


Authors and affiliation (s):

Soumia Chirani1,2, Mohamed Oussama Lebig1, Sarah Bouameur2,3, Meriyem Mouffok1, Naziha Chirani4,5, Nafa Chafi*1,4, Kaddour Guemra1,4

1Laboratory of Organic Physical and Macromolecular Chemistry, Faculty of Exact Sciences, University DjillaliLiabes of SidiBel-Abbes, ALGERIA.

2Department of Pharmacy, Faculty of Medicine Sciences, University DjillaliLiabes of SidiBel-Abbes, ALGERIA.

3Hospitalo-Universitary Center C.H.U of Sidi Bel-Abbes, 22 000 ALGÉRIA.

4Department of Chemistry, Faculty of Exact Sciences, University DjillaliLiabes of SidiBel-Abbes, ALGERIA.

5Laboratory of Innovation and BioperformanceAnalyse -LIAB, Polytechnic School, University of Montreal Quebec, CANADA.

Abstract:

Introduction: The present paper provides details of preparation of hardcapsules based on microspheres containing 2-aminothiazole as an antithyroidian agent and synthesized poly(butylsuccinate) (PBS) or ethylcellulose(EC10) as biodegradable matrices as well as the study of the drug delivery. Methods: A disintegration tests of these gelatinous capsules were done. The biodegradable synthesized polyester was characterized by infrared spectroscopy, nuclear magnetic resonance (mono and bidimentional H1NMR, 13CNMR) and by Differential Scanning Calorimetry (DSC). A viscosimetric study has been done in order to evaluate viscosimetric PBS's weight wich was calculated from Mark-Houwink equation. The microencapsulation of 2-aminothiazole was done using solvent evaporation technique. Results: Microspheres were spherical and the effects of varying emulsifiers and blades number on microspheres encapsulation efficiency were evaluated. A kinetic studies of releases of 2-aminothiazole in gastric pH were done in order to evaluate the best late effect and then the best formulation.

Key words: Antithyroidian agent, Microspheres, Biodegradable polymer matrix, Capsules, Drug release, Kinetic study.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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