Recent Advances and Appropriate Use of Niosomes for the Treatment of Skin Cancer

Indian Journal of Pharmaceutical Education and Research

  • Pottathil Shinu1Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  • Anroop B Nair2Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  • Beena Kumari3Department of Pharmaceutics, Indira Gandhi University, Meerpur, Rewari, Haryana, INDIA.
  • Shery Jacob4Department of Pharmaceutical Sciences, College of Pharmacy, Gulf Medical University, Ajman, UAE.
  • Manish Kumar5Department of Pharmaceutics, M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University) Ambala, Haryana, INDIA.
  • Abhishek Tiwari6Department of Pharmaceutical Sciences, Pharmacy Academy, IFTM University, Moradabad, Uttar Pradesh, INDIA.
  • Varsha Tiwari6Department of Pharmaceutical Sciences, Pharmacy Academy, IFTM University, Moradabad, Uttar Pradesh, INDIA.
  • Katharigatta N Venugopala2Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA., 7Department of Biotechnology and Food Science, Faculty of Applied Sciences, Durban University of Technology, Durban, SOUTH AFRICA.
  • Mahesh Attimarad2Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  • Sreeharsha Nagaraja2Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA., 8Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, Karnataka, INDIA.

Volume 56 Issue 4 Pages 924-937

DOI: 10.5530/ijper.56.4.170

Abstract

Both melanoma and non-melanoma are the most common types of skin cancers affecting various populations across the globe. Skin malignancy is more prevalent among Caucasian populations. Non-melanoma types of skin cancers are further classified as basal cell and squamous cell carcinomas, respectively. The incidence of non-melanoma type of cancers is relatively higher than melanoma type of skin cancers. Recently published data shows that melanoma of the skin stands as the seventeenth most common type of cancer across the world. Niosome is a drug carrier in a novel drug delivery system wherein the drug is enclosed within the vesicle, which is made up of non-ionic surfactants that are stabilized by the addition of cholesterol. Niosomes help to overcome certain difficulties of skin drug deliveries such as insolubility, instability, low bioavailability, and fast debasement of medications. This review article mainly focuses on the use of niosomes in dermatology particularly aiming at the delivery of drugs via skin. In addition, this review discusses the specific use of niosomal drug delivery systems that may be useful in clinics. The niosomes are gaining popularity in the field of topical drug delivery due to their excellent characteristics like proficiency to carry both hydrophilic and lipophilic drugs, increasing the penetration of drugs, and enhancing drug stability and drug release at sustained levels.

Keywords

  • Niosomes
  • Drug carrier
  • Skin cancer
  • Penetration enhancer
  • Dosage form
  • Drug delivery
  • Drug therapy
  • Cancer treatment
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