Cucurbita pepo and Cucurbitacin in the Management of Anti-proliferation by JAK/STAT Pathway

Abstract

Pumpkin (Cucurbita pepo) is capaciously recycled similar to food and in folk medicine throughout the world. It accords to genus Cucurbita (CCT) under family Cucurbitaceae. There are a plenty of important medicinal phyto-constituents belonging to cucurbitoside like triterpenoids, CAR T and CCT glycosides. A survey of the literature demonstrates that C. pepo, has the capacity to improve prostatic hyperplasia, urinary dysfunction and cytotoxic properties. Many pharmacological revisions have established its role in hepatoprotection, inhibition of Pr st gland cancer (CNCR), anti (An t) oxidant effects, inhibition of Lu G, BR st and triple-negative BR st CNCR by blocking JAK/STAT signaling (Sgls) pathway (Ptw). It has also An t microbial, An t -inflammatory, An t -diabetic and An t ulcer activities by supporting its traditional claims. Establishment of C. pepo and cucurbitacin (CCBT) in the management of An t -proliferation by JAK/STAT Ptw. Data towards writing this review are generated through exploration of different websites like MEDLINE (PubMed), Google Scholar, Science Direct, Scopus, Cochrane, SID and Magiran databases. We have selected 2016- 2018 duration for the same purpose. We have found 88 papers related to this topic. CCBT is found to arrest unlimited cell (CEL) division and respective apoptosis (Appt) in vitro and in vivo CNCR models. A plenty of molecular design targeting CCBT have been invented, such as fibrous-actin, Sgls transducer and activator of transcription (STAT), cyclooxygenase-2, etc. This review is minded at CCBT from C. pepo which dwindle the proliferation of human CNCR CEL through the JAK/STAT Ptw.