Recent Developments on Pharmacological Potential of 1,3,4-Oxadiazole Scaffold

Indian Journal of Pharmaceutical Education and Research

  • Bhutani Rubina1Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research, New Delhi, INDIA.
  • Pathak Dharam P1Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research, New Delhi, INDIA.
  • Kapoor Garima1Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research, New Delhi, INDIA.
  • Kant Ravi1Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research, New Delhi, INDIA.
  • Dutta Manni2School of Medical and Allied Sciences, GD Goenka University, Gurgaon, Haryana, INDIA.

Volume 53 Issue 2s Pages s1-s16

DOI: 10.5530/ijper.53.2s.44

Abstract

Heterocyclic compounds represent the important structural key in pharmaceutical medicinal chemistry. In literature, five-membered heterocycles are reported to be a core moiety of various pharmaceutical drugs. 1,3,4-oxadiazole scaffold, among various five-membered heterocycles is an important molecule which attracts various medicinal chemist to develop a novel biologically active molecule. 1,3,4-Oxadiazole is found to bear important pharmacological activities such as anti-diabetic, antimicrobial, anti-cancer, anticonvulsant, antioxidant, anti-Alzheimer’s, anti-inflammatory, antiviral, cardiovascular, anti-tuberculosis, anti-pyretic, insecticidal. This review compiles the biological updates on various compounds containing 1,3,4-oxadiazole as a core moiety from the recent years.

Keywords

  • Anti-diabetic
  • Anti-cancer
  • Heterocycle
  • Oxadiazole
  • Pharmacological activity
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