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Published on:August 2016
Indian Journal of Pharmaceutical Education and Research, 2016; 50(3):465-471
Original Article | doi:10.5530/ijper.50.3.21

Synthesis, Evaluation and Molecular Docking Study of Some New Acetic Acid Derivatives.


Authors and affiliation (s):

Shashidhar Kerur1*, Kallanagouda Alagawadi2, Hailiang Zhu3 and Fakkirappa Manvi2

1Deparment of Pharmaceutical Chemistry, Karnataka Lingayath Education University College of Pharmacy, Hubli-580031, INDIA

2Deparment of Pharmaceutical Chemistry, Karnataka Lingayath Education University College of Pharmacy, Belgaum-580010, INDIA.

3State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing-210093, CHINA.

Abstract:

In the present study synthesis and antimicrobial activity of some new 2-[(2,5-disubstitutedanilino)phenyl]acetic acid derivatives 5a-f are described. The structures of the newly synthesized compounds were confirmed by FTIR, 1H NMR, 13C NMR, mass and elemental analysis. All compounds were screened for antitubercular and antimicrobial activity. Molecular modeling studies were performed to dock compounds into the ecKAS III binding site, which suggested probable inhibition mechanism. The results revealed that most of the compounds showed high to moderate biological activity against tested microorganisms.

Key words: 1,3,4-Thiadiazole, Phenacyl bromide, Molecular Docking, Antitubercular activity, Antimicrobial activity, Mycobacterium tuberculosis.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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