Home | Articles
Published on:August 2016
10.5530/ijper.50.3.20, 2016; 50(3):458-464
Original Article | doi:10.5530/ijper.50.3.20

A Diterpenoid Taxoquinone from Metasequoia Glyptostroboides with Pharmacological Potential.

Authors and affiliation (s):

Vivek Kumar Bajpai1, Irfan Ahmad Rather1, Sun Chul Kang2*, Yong-Ha Park1*

1Department of Applied Microbiology and Biotechnology, School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbook 712-749, KOREA.

2Department of Biotechnology, College of Engineering, Daegu University, Gyeongsan, Gyeongbook 712-714, KOREA.


Background: The ubiquitin-proteasome pathway plays an important role in selective protein degradation and regulates multiple cellular processes, including cell cycle progression, proliferation and apoptosis. Cancer cells are more sensitive to the pro-apoptotic effects of proteasome inhibition than normal cells, hence, proteasome inhibitors can be used as novel anticancer drugs. Further, influenzacommonly known as “flu” is a contagious respiratory disease caused by sub-type of influenza A virus H1N1 which has resulted in enormous medical attention world-wide. Natural products are well known for their pharmacological potential in anticancer and antiviral therapies. Methods: In this study, an abietane-type diterpenoid, taxoquinone, isolated from Metasequoia glyptostroboides, was assessed for the first time for its therapeutic efficacy as a potential inhibitor of influenza A (H1N1) virus and 20S proteasomeusing cytopathic reduction assay and proteasome inhibition assay, respectively. Results: The taxoquinonedisplayed its anticancer effect in terms its ability to inhibit 20S human proteasome with IC50 value of 8.2 ± 2.4 μg/μL. Moreover, taxoquinone (500 μg/mL) displayed significant antiviral effect against H1N1 influenza virus in cytopathic reduction assay on MDCK cell line. Conclusion: These finding confirm pharmaceutical potential of taxoquinone as a novel therapeutic agent.

Key words: Anticancer, Antiviral, Taxoquinone, Diterpenoid, Metasequoia glyptostroboides.



Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the Latest Release of Journal Citation Reports (source: Web of Science Data).


Impact Factor® as reported in the 2021 Journal Citation Reports® (Clarivate Analytics, 2022): 0.843

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs