Home | Articles
Published on:August 2016
Indian Journal of Pharmaceutical Education and Research, 2016; 50(3):451-457
Original Article | doi:10.5530/ijper.50.3.19

Administration of Fresh Juice of Tinospora cordifolia Decreases Levels of Urinary Markers of Peroxisome Proliferator-Activated Receptors in Hyperlipidemic Patients

Authors and affiliation (s):

Amey R. Shirolkar1 and Rajesh Dabur1,2*

1Department of Biochemistry, National Research Institute of Basic Ayurvedic Sciences, Pune, Maharashtra-411038, INDIA.

2Department of Biochemistry, Maharshi Dayanand University, Rohtak, Haryana-124001, INDIA.


Objective: Tinospora cordifolia (Willd.) Miers juice (TCJ) is known for its anti-hyperlipidemic properties. This study was aimed to validate the efficacy of TCJ to activate PPARα in vivo in hyperlipidemic (HPL) patients. Materials and Methods: HPL (n=20) and healthy (n=22) volunteers were enrolled in the study. HPL patients were treated with TCJ for 14 days. The fasting urine and blood samples were collected on 0 and 14th day for analysis. The blood samples were used for biochemical analysis. Urine samples were subjected to LC-ESI-QTOFMS for the analysis of PPAR-α markers. Results: Treatment with TCJ depleted cholesterol (TC-24%), triglycerides (TG-28%) and low density lipoprotein (LDL- 14%) levels and increased high density lipoprotein (HDL) (p<0.05) levels in HPL. The QTOFMS data revealed increased urinary excretions of pantothenic acid (5.99 fold), hippuric acid (<15.0 fold), acylcarnitines (<2.0 folds) and branched chain amino acids (BCAA) in HPL patients which significantly depleted (p<0.01) after TCJ treatment. Two new acylcarnitines, L-hexanoylcarnitine and 4-hydroxyisovaleric acid observed in HPL patients were depleted (>2.0 fold) after treatment with TCJ. The other biomarkers of HPL, ursodeoxycholic acid and chenodeoxycholic acid were also depleted (>4.0 fold) after TCJ treatment. Conclusion: The present data clearly depicted the regulatory effects of TCJ on the lipid metabolism. It emphasize that TCJ activates PPAR-α in vivo that decreased the urinary levels of PPARα biomarkers.

Key words: Tinospora cordifolia, Urinary biomarkers, LC-ESI-QTOFMS, PPAR-alpha, Fatty acids ß oxidation, Oxidative stress.



Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the Latest Release of Journal Citation Reports (source: Web of Science Data).


Impact Factor® as reported in the 2023 Journal Citation Reports® (Clarivate Analytics, 2023): 0.8

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs