Synthesis and Pharmacological Evaluation of New 4-Aryl-3,4,5,6,7,8- hexahydroquinazolin-2(1H)-thiones

Indian Journal of Pharmaceutical Education and Research

  • C.M Aslak1Department of pharmaceutical chemistry, JKK Munirajah Medical Research Foundation, College of Pharmacy, Komarapalayam - 638 183 Tamilnadu, India.
  • B. Jayalakshmi1Department of pharmaceutical chemistry, JKK Munirajah Medical Research Foundation, College of Pharmacy, Komarapalayam - 638 183 Tamilnadu, India.
  • A. Balasubramaniam1Department of pharmaceutical chemistry, JKK Munirajah Medical Research Foundation, College of Pharmacy, Komarapalayam - 638 183 Tamilnadu, India.
  • N. Senthilkumar1Department of pharmaceutical chemistry, JKK Munirajah Medical Research Foundation, College of Pharmacy, Komarapalayam - 638 183 Tamilnadu, India.

Volume 46 Issue 3 Pages 206-210

DOI:

Abstract

New 4-aryl substituted quinazolin-2-thiones were synthesized and confirmed by spectral studies like IR and NMR. Then screened for antimicrobial, analgesic, anti-inflammatory and CNS depressant activities. All the derivatives were showing the pharmacological activity mainly due to the presence of basic nucleus, quinazolin-2-thione and was modified with various substituents at 4th position with different aryl substituents. Among all the substituents, the halogen substituted compounds are comparatively more active.

Keywords

  • Quinazolinones
  • cyclohexanone
  • chalcones
  • Aldol condensation
  • cylization
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