Development and In Vitro Evaluation of Buccal Tablet of Quinapril Hydrochloride

Abstract:

Quinapril hydrochloride is reported to have low oral bioavailability due to an extensive hepatic first pass effect. In the present work bilayered ® buccoadhesive tablet of quinapril hydrochloride was prepared. Carbopol 974P and hydroxypropylmethylcellulose K4M were chosen as the bioadhesive polymers to formulate buccal tablets of the drug. Citric acid was chosen as the permeation enhancer. The formulations were evaluated for weight, hardness, friability, swelling rate, in vitro bioadhesion force, in vitro residence time, ex vivo diffusion study and drug release. The optimized formulation containing 10% Carbopol 974P and 1.2% citric acid was found to give 98.3% drug release at the end of 3 h 2 with a bioadhesion force of 553.9 dynes/cm and enhancement ratio of 2.6. High flux value in presence of penetration enhancer indicated increased penetration of drug across the buccal mucosa which can result in improved bioavailability.

Keywords: Buccoadhesive tablet, quinapril hydrochloride, permeation enhancer, ex vivo diffusion study, in vitro bioadhesion force, in vitro residence time