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Published on:15th July 2014
Indian Journal of Pharmaceutical Education and Research, 2014; 48(3):48-59
Pharmaceutical Research | doi:10.5530/ijper.48.3.7

Evaluation of Hydrophilic Polymers and their Combinations in Formulation of Sustained-Release Matrix Tablets of Water-Soluble Drug

Authors and affiliation (s):

B. S. Manjula, A. Srinatha* and B. K. Sridhar

Department of Pharmaceutics, National College of Pharmacy, Shimoga, India


The present study was aimed to investigate matrix-forming property of gum olibanum for sustained-release tablets of tramadol, a freely water-soluble drug. The possible synergistic effect of gum olibanum with hydroxypropyl methylcellulose (HPMC) and xanthan gum, and widely used pharmaceutical excipients on tablet properties was investigated. Matrix tablets were prepared containing polymers, either alone or in combinations, by wet granulation. Tablets were evaluated for their physico-mechanical properties, drug release and hydration properties. Tablets swelling increased till ~3-4 h which was followed by a decline phase.. Drug release from the matrix tablets was dependent on the concentration of gum olibanum. Formulation with drug: gum olibanum in 1:2 released 94.37 ± 2.37% drug in 6 h. The drug release data was analyzed by model dependent and model independent equations. Combination of gum olibanum with HPMC or xanthan gum matrices significantly (p<0.05) modulated drug release, which was reflected by the mean dissolution times (MDTs). Incorporation of lactose induced faster drug release compared to dicalcium phosphate and microcrystalline cellulose.. Drug release largely followed firstorder kinetics and non-Fickian type of diffusion.

Key words: Diffusion, excipients, hydrophilic, similarity factor, gum olibanum.



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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