In vitro and in vivo Wound Healing Potential of Plant Commiphora caudata

Abstract:

Background: Commiphora caudata is commonly called hill mango, an incredibly available species of Commiphora, and belongs to Burseraceae. Commiphora caudata is commonly used in Ayurveda and Siddha medicines. Different parts of the plant have many pharmacological activities like antiviral, antispasmodic, cytotoxic, hypothermic activity, antiacne, hepatoprotective, febrifuge, antibacterial, antioxidant, and anti-inflammatory activities. Materials and Methods: Extracts were prepared by successive solvent extraction, In vitro studies like, MTT assay, scratch assay, Estimation of Inflammatory Marker IL-6 by Enzyme-Linked Immuno sorbent Assay (ELISA test), determination of hydroxyproline, estimation of total protein, in vivo excision wound model and diabetic model were done. Results: In all the chloroform extract of Commiphora caudata has shown a good wound-healing property. Conclusion: Based on the ethnic medical uses and proven biological activities, the gum blended in with water is utilized as a mouthwash to cure mouth ulcers and is utilized for wound healing and rheumatoid arthritis., current work focused on proving wound healing potential of plant Commiphora caudata.

Keywords: Commiphora caudata, MTT, Scratch assay, IL-6, Excision, Diabetic model.