Evaluation of Potentiality of Salvia hispanica in the Management of Irritable Bowel Syndrome in Wistar Albino Rats

Abstract:

Introduction: Globally, approximately 11% of the population has been affected by the irritable bowel syndrome. Recent advancement in medical area have made it easily possible to find out the proper pathophysiology behind the generation of symptoms of irritable bowel syndrome followed by its treatment. Objective: The aim of this research is to check the effect of mucilage of Salvia hispanica on gastrointestinal tract symptoms (IBS) as a result of excessive fibers availability in the mucilage. Materials and Methods: The anti-IBS activity was seen in rats by using the various animal experimental models. The anti-IBS activity of Salvia hispanica mucilage (100 mg/ kg, p.o.) in rats was checked by using the Water Avoidance Stress Model (WAS), Food Related model of IBS and Croton oil Induced Hemorrhoids. For the estimation of effect of monoamine on GIT fluorimeter was used to check the level of serotonin and iliac motility of rats were also checked. Results: It was found out that Salvia hispanica mucilage had contractile action on iliac motility that leads to the shortening the evacuation time of bowel and relief in constipation. From the data collected by using above methods. Conclusion: It was concluded that the Salvia hispanica mucilage revealed to possess activity against IBS significantly (****p<0.0001) at a dose of 100 mg/kg. Activity against IBS was supported by enhanced serotonin level in the gastrointestinal tract.

Keywords: IBS, Salvia hispanic mucilage, Water Avoidance Stress Model, Serotonin, Food Related Stress Model of IBS.