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Published on:May 2023
Indian Journal of Pharmaceutical Education and Research, 2023; 57(2s):s399-s404.
Original Article | doi:10.5530/ijper.57.2s.46

Design, Synthesis and Biological Screening of Novel Carbazole Tethered Oxyethylamino Derivatives as Antimicrobial Agent


Authors and affiliation (s):

Prafulla M Sabale1,*, Nusrat Sayyad B1, Lata Potey C2

1Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Amravati Road, Nagpur, Maharashtra, INDIA.

2School of Pharmacy, G. H. Raisoni University, Saikheda, Madhya Pradesh, INDIA.

Abstract:

Background: Carbazole is an important scaffold known to be associated with several biological activities including antimicrobial activities. Incorporation 4-oxothiazolidine moiety in carbazole moiety may lead to a new series of antimicrobials compounds. Aim: In this study, design and synthesis of novel carbazole tethered oxyethylamino was started with carbazole as basic pharmacophore and evaluated for antimicrobial activity. Materials and Methods: Molecular docking of carbazole derivatives was carried out by Schrödinger (Maestro 10.5v) active compound were Synthesized and screened for in vitro antimicrobial activity against Candida albicans and gram-positive and gram-negative bacterial strains such as Staphylococcus aureus, Bacillus subtilis, E. coli. MIC was calculated by standard agar tube dilution method. Results: All Compounds shown good antimicrobial activity at 25 (μg/ml) – 510 (μg/ml). The molecular docking studies demonstrated ligand protein interaction. Conclusion: carbazole represent novel set of lead for the designing of novel antimicrobial agents.

Keywords: Molecular Docking, Carbazole, Oxyethylamino, Antimicrobial activity, Antifungal activity.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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