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Published on:May 2023
Indian Journal of Pharmaceutical Education and Research, 2023; 57(2s):s244-s249.
Original Article | doi:10.5530/ijper.57.2s.28

Formulation and Characterization Sustained Release Mucoadhesive Microcapsule of Baclofen


Authors and affiliation (s):

Kunal V Bhambar1, Rajendra S Bhambar2,*, Pravin P Gadakh1

1Department of Pharmaceutical Quality Assurance, MGV’s Pharmacy College, Panchavati, Nashik, Maharashtra, INDIA.

2Department of Pharmacognosy, MGV’s Pharmacy College, Panchavati, Nashik, Maharashtra, INDIA.

Abstract:

Background: Baclofen is used as skeletal muscle relaxant. Baclofen inhibit Polysynaptic and monosynaptic reflexes a hyperpolarisation. Baclofen drug absorbed rapidly and excreted in feces urine in unchanged form. Objectives: Aim of the current study was to formulate sustained release mucoadhesive microcapsules of Baclofen using different polymers like Chitosan, Carbopol934P, HPMC K4M. Materials and Methods: Ionotropic gelation method was used for preparation of microcapsules of baclofen. Dispersion of polymers and baclofen was dropwise added sodium tripolyphosphate solution to form microcapsule. The prepared microcapsules were evaluated for FTIR studies, micromeritic properties, drug entrapment efficiency, particle size and shape, SEM, swelling index, mucoadhesive strength, in vitro release studies. Results: Angle of repose of prepared microcapsules was in range 24.48 ± 1.39 to 38.08±1.67 showed good flowability. Prepared microcapsules showed bulk density in the range of 0.49±0.04 to1.22±0.06. All formulations showed Carr’s index and Hausner’s ratio in the range of 14.68 ±1.20 to 29.56 ± 1.97 and 1.16±0.012 to 1.25±0.016 respectively. Formulation F1 to F3 prepared with HPMC (K4M) showed drug release 77.78%, 74.94%, 77.99% and formulation F4 to F6 prepared with Carbopol 934P showed drug release 78.20%, 79.05%, 87.48% respectively in 12hr. Conclusion: Sustained release profile F6 formulation was obtained due to significant mucoadhesive efficiency of the Carbopol 934P. Hence the mucoadhesive microcapsules of Baclofen would be an effective strategy for the management of Muscle Pain.

Keywords: Baclofen, Microcapsule, Carbopol 934P, HPMC K4M, Sustained Release.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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