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Published on:October 2022
Indian Journal of Pharmaceutical Education and Research, 2022; 56(4s):s695-s702
Original Article | doi:10.5530/ijper.56.4s.215

Saccharomyces cerevisiae Catalyzed Synthesis and Evaluation of Pyrazoles


Authors and affiliation (s):

Thangavelu Rajkumar1*, Suresh Kumar Solleti Venkata2, Srinivasan Nagarajan3

1Department of Pharmaceutical Chemistry, Creative Educational Society’s College of Pharmacy, Kurnool, Andhra Pradesh, INDIA.

2Department of Pharmacognosy, Creative Educational Society’s College of Pharmacy, Kurnool, Andhra Pradesh, INDIA.

3Department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, INDIA.

Abstract:

Background: Biocatalysis in organic solvents has several benefits over aqueous solvents, including solubility of organic substrates, ease of workup, separation of the product, and, in certain cases, reusability of biocatalysts. Materials and Methods: A simple, effective, and environmentally friendly technique for synthesizing pyrazoles has been established, which involves the cyclo condensation of chalcones and isonicotinic acid hydrazide in organic solvents using a relatively inexpensive catalyst baker’s yeast (Saccharomyces cerevisiae). Molecular properties prediction and docking studies were also performed. Results: The predicted molecular properties suggest that the molecules are safe for oral consumption and their docking studies on 2BVC-Mycobacterium tuberculosis glutamine synthetase show their favorable ligand binding nature. The structural assignments were validated based on spectrum data. The compounds were evaluated for their antitubercular, in vitro anti-inflammatory, and anti-oxidant effects. The analysis reveals that synthesized derivatives of pyrazoles possessing methoxy, nitro, hydroxyl, fluoro, and chloro substitution through the phenyl ring help the molecule to increase its pharmacological activities. However, the substituted thiophene ring in the side chain also facilitates the biological action of the molecules. Conclusion: Anti-inflammatory, anti-oxidant, and anti-tubercular properties are due to the presence of the pyrazole ring.

Keywords: Pyrazoles, Chalcones, Saccharomyces cerevisiae, In vitro Anti-inflammatory, Antioxidant, Anti-tubercular.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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