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Published on:June 2022
Indian Journal of Pharmaceutical Education and Research, 2022; 56(3):740-747
Original Article | doi:10.5530/ijper.56.3.123

Effects of Arbutin on Fatty Acid Levels of Erythrocyte and Serum in Wistar Albino Rats Treated with Potassium Bromate

Authors and affiliation (s):

H Turan Akkoyun1,*, Sevinç Aydın2, Mahire Bayramoglu Akkoyun1, Aydın Şükrü Bengü3, Suat Ekin4, Sinem Aslan Erdem5

1Faculty of Veterinary Science, Department of Basic Sciences, Siirt University, Siirt, TURKEY.

2Çemişgezek Vocational School, Munzur University, Tunceli, TURKEY.

3Department of Medical Services and Technics, Vocational School of Health, Bingöl University, TURKEY.

4Van Yuzuncu Yil University, Faculty of Science, Department of Chemistry, Van, TURKEY.

5Faculty of Pharmacy, Department of Pharmacy Professional Sciences, Ankara University, Ankara, TURKEY.


Background: In the presented study; the Effects of Arbutin (ARB) on the Rat Erythrocyte and serum fatty acid profile which is exposed to potassium bromate (KBrO3) were investigated. Materials and Methods: In this study, 32 Wistar albino rats weighing 250-300 g were used divided into 4 groups. Groups 1: control, group 2: KBrO3 (single dose 100 mg / kg gavage), group 3: ARB (50 mg / kg / day (ip) for 5 days), group 4: KBrO3 + ARB. At the end of the 5th day, alteration of fatty acid profile in erythrocyte and serum of rats in all groups was examined. Results: Rat serum essential fatty acid; palmitic acid (C16:0), myristic acid (C14:0), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), erythrocyte major fatty acids; palmitic acid (C16:0), myristic acid (C14:0), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), arachidic acid (C20:0), eicosenoic acid (C20:1), and lignoceric acid (C24:0). In addition, in our studied serum and erythrocytes; Total monounsaturated fatty acids (MUFA) varied between 8.91 ± 0.53- 11.71 ± 2.55 and 33.71 ± 2.12- 37.11 ± 2.12, respectively. It was determined that total polyunsaturated fatty acids (PUFA) varied between 5.90 ± 1.29- 9.96 ± 1.18 and 14.72 ± 3.66- 22.13 ± 4.82, respectively. Conclusion: In our study, alterations in fatty acid contents were observed, and results suggesting that arbutine affects the enzymes involved in Fatty acid metabolism and has an effect on fatty acid amounts.

Keywords: Arbutin (ARB), Potassium bromate (KBrO3), Fatty acid (FA), Polyunsaturated fatty acids (PUFA), Monounsaturated fatty acids (MUFA), Wistar Albino Rat.



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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