Evaluation of Chronic Constriction Injury Induced Neuropathic Pain using Chrysin in Rats

Abstract:

Introduction: The exhaustive literature review suggested the vast pharmacological profile of chrysin but this drug has not been scientifically reported in the healing of nerve pain till date. The nerve pain is linked with various diseases such as cancer, inflammation, diabetic and mental problems. Neuropathic pain has been viably prompted in rodents by chronic constriction injury (CCI) of sciatic nerve. Objectives: The natural phytoconstituent chrysin will be investigated for neuropathic pain using well established models. Methods:The neuroprotective action of chrysin on neuropathic pain and tissue biomarkers was measured using standardized experimental tests reported in references books. Results:The delivery of chrysin (50 and 100 mg/kg; p.o.) for 15 continuous days showed critical neuropathic pain inhibitory action with respect to control and measurably identical to standard medication in all experimental models via dose dependent manner. The level of TBARS was declined by chrysin for the 15 days while levels of reduced glutathione and total protein were expanded with respect to control and measurably identical to standard medication. Chrysin is one of huge herbal medication to rummage free radicals in the natural structure and it also control the free radical related lipid peroxidation process in the pathogenesis of neuropathic pain. Conclusion: It can be concluded that, extraordinary expansive assessments are required to develop this medicinal activity by using distinctive animal model of neuropathic pain. Additionally, growing the healing impact of chrysin and various flavonoids may give exceptional assistance to finish the further examination in clinical research plan.

Key words: Biomarker, Chrysin, Flavonoid, Gabapentin, Neuropathy, Pain.