Home | Articles
Published on:June 2022
Indian Journal of Pharmaceutical Education and Research , 2022; 56(3):748-755
Original Article | doi:10.5530/ijper.56.3.124

The Neuroprotective Effects of Memantine, and Curcumin after Cerebral Ischemia-reperfusion Injury in Elderly Rats


Authors and affiliation (s):

Murat Cabalar1,*, Serdar Altınay2, Funda Yildirim3, Duygu Sultan Celik4, Suat Hayri Kucuk5, Cihan Isler6, Nilgun Isiksacan7, Arsida Bajrami1, Ahmet Gulcubuk3

1Department of Neurology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, TURKEY.

2Department of Pathology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, TURKEY.

3Department of Pathology, Faculty of Veterinary Medicine, Istanbul University, TURKEY.

4Department of Animal Center, Bagcilar Training and Research Hospital, Istanbul, TURKEY.

5Department of Biochemistry, Bagcilar Training and Research Hospital, University of Health Sciences, Istanbul, TURKEY.

6Department of Neurosurgery, Faculty of Medicine Cerrahpasa, Istanbul University, Istanbul, TURKEY.

7Department of Biochemistry, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, TURKEY.

Abstract:

Background: Some researches reveal that pharmacologic and phytotherapeutic agents have benefits on neurological disorders associated with the effects of reactive oxygen species. Aim: The purpose of this research was to evaluate the protective effects of curcumin and memantine in a cerebral ischemia/reperfusion model in rats. Materials and Methods: This experimental study was conducted at the Bagcilar Training and Research Hospital, Istanbul, Turkey. Rats were separated into five experimental groups (n=8) as follows: Curcumin (Group I), Memantine (Group II), Curcumin+Memantine (Group III), ischemia (Group IV), and sham (Group V). Cerebral ischemia was performed surgically with bilateral common carotid artery occlusion for 30 min, followed by reperfusion for 72 hr. Tissue and serum samples were collected and assessed for tumor necrosis factor-α, interleukin-6, lactate dehydrogenase, catalase, glutathione peroxidase, xanthine dehydrogenase, superoxide dismutase, and malondialdehyde levels. Further, in tissue samples, both neuronal loss and caspase-3 levels were determined. Results: Serum and tissue levels of interleukin-6, tumor necrosis factor-α, malondialdehyde, and lactate dehydrogenase were found significantly lower in the Group I, II, and III compared to Group IV (p<0.001). Glutathione peroxidase, superoxide dismutase, and catalase levels in Group I, II, and III were significantly higher than those of Group IV (p<0.001). Conclusion: Curcumin, Memantine, and Curcumin+Memantine treatment were found to be efficacious in decreasing oxidative damage in cerebral ischemia but failed to prevent tissue damage.

Keywords: Brain ischemia, Curcumin, Memantine, Oxidative injury, Reperfusion.

 




 

Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the Latest Release of Journal Citation Reports (source: Web of Science Data).

 

Impact Factor® as reported in the 2021 Journal Citation Reports® (Clarivate Analytics, 2022): 0.843

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

DOI HISTORY

IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs