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Published on:March 2022
Indian Journal of Pharmaceutical Education and Research, 2022; 56(2):347-355
Review Article | doi:10.5530/ijper.56.2.54

A Brief Review on Solubility Enhancement Technique: Hydrotropy


Authors and affiliation (s):

Bhavesh Namdev1, Senthil Venkatachalam1,*, N Jawahar1, Anushma Chorsiya2

1Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris, Tamil Nadu, INDIA.

2Department of Pharmacognosy and Phytochemistry, Delhi Pharmaceutical Sciences and Research University, New Delhi, Delhi, INDIA

Abstract:

In this review we have elaborated about number of hypothesis postulated to understand the mechanism of hydrotropic agents, although majority of the postulated hypothesis haven’t justified the solubility enhancement mechanism. Further to it the articles focuses upon the parameters affecting enhancement of solubilizing ability. Hydrotropes are extensively used in drug solubilization, extraction agents for various phytoconstituents, separation agent used for pharmaceutical analysis, as well as for increasing the rate and yield of a chemical reaction due to their unique features. Because of this, hydrotropic solutions possess high industrial demand. While mixed hydrotropy is mostly used in enhancement of solubility, extraction of phytoconstituents and separation by the use of more than one hydrotropic agent. This review article also highlights the applications and future prospects with the employment of hydrotropes and hydrotropic agents in novel drug delivery or parental or oral or tropical systems to enhance solubility profile the drugsare also discussed.

Key words: Mixed Hydrotropy, Solubilizing agent, Mechanisms of hydrotropes, Application of Hydrotropes, Solubility, Bioavailability enhancement.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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