Formulation of Gastroretentive Floating Drug Delivery System of Indomethacin

Abstract:

Indomethacin (NASID) is used as potent anti-inflammatory drug with prompt antipyretic action, mainly used for the treatment of osteoarthritis with half-life of 4.5 hours. The basic objective of present work was to prepare floating delivery system of Indomethacin for once a day formulation using gas formation technique for prolonging the gastric residence time, so that the dosage regimen and gastric irritancy can be reduced. Indomethacin was estimated in the formulation by using UV/Visible spectrophotometer (Shimazdu UV-1700) at 321 nm. Tablets were evaluated for various parameters and it was observed that the formulation having 75 mg of Indomethacin, 34% HPMC K4M, 12% sodium bi-carbonate and 20% of lactose shows better result having 96.37% drug release within 24 hr with floating lag time of 155 seconds and floating time of 22 hr. It was also observed that as the concentration of gas generating and channeling agent increases, the chances of burst release and tablet erosion increases simultaneously. In the present study it was concluded that the floating drug delivery system with reduced floating lag time and sustained drug release of Indomethacin was obtained and could be a promising gastro-retentive drug delivery system.

Key words: Floating drug delivery, Floating time, HPMC, Channeling agent.